Aging population forces millions of people to undergo implant surgery for total hip and knee replacement, scoliosis, maxillofacial fixation, and traumatic condition. However, many of these implants fail due to:
- implant loosening: lack of necessary new bone formation to repair large bone defects or suitable integration with the existing bone and;
- implant-associated infection, despite a novel engineering design, sterilized operating theatre environment, and prophylaxis antibiotic therapy.
Our research primarily concerns the designing and synthesizing of new biomaterials. We particularly utilize a combination of additive manufacturing, surface engineering, and controlled drug delivery through micro/nanoencapsulation to treat bone and joint disease. In the last five years, our group has initiated a novel line of research in which we study different surface bio-functionalization strategies to achieve optimal implants, offering multiple functionalities to prevent implant failures.
What if we could make implants last longer?
Right now, infection is one of the major complications in implant surgeries, decreasing quality of life and increasing healthcare cost. Functional biomaterials that can be used as an antibacterial coating for implants may help to overcome this issue.
Our team devotes their time and energy to the refinement of these materials, that have the potential to increase implant longevity. Watch the pitch by associate professor Saber Amin Yavari below to see how he aims to solve both patients’ and doctors’ problems!
Contact for internships
Dr. Saber Amin Yavari, S.AminYavari@umcutrecht.nl
Principal Investigator, Group leader
Nanoparticle-based coating for bone regeneration and implant related infection
Advanced materials for regenerative medicine and tissue engineering
Multicellular in vitro model to monitor biomaterials bio-functionality
Immunomodulatory surfaces to prevent implant related infection
Surface engineering strategies to improve bone regeneration of orthopedic implant
Saber Amin Yavari, Suzanne M. Castenmiller, Jos A. G. van Strijp, Michiel Croes, Combating Implant Infections: Shifting Focus from Bacteria to Host, Advanced Materials, 32 (2020) 2002962. https://doi.org/10.1002/adma.202002962
F. Jahanmard, M. Croes, M. Castilho, A. Majed, M.J. Steenbergen, K. Lietaert, H.C. Vogely, B.C.H. van der Wal, D.A.C. Stapels, J. Malda, T. Vermonden, S. Amin Yavari, Bactericidal coating to prevent early and delayed implant- related infections, Journal of Controlled Release, 326 (2020) 38–52. https://doi.org/10.1016/j.jconrel.2020.06.014
A. Khodaei, F. Jahanmard, H.R. Madaah Hosseini, R. Bagheri, A. Dabbagh, H. Weinans, S. Amin Yavari, Controlled temperature-mediated curcumin release from magneto-thermal nanocarriers to kill bone tumors, Bioactive Materials, (2021) in press. https://doi.org/10.1016/j.bioactmat.2021.09.028
M. Croes, B. Akhavan, O. Sharifahmadian, H. Fan, R. Mertens, R.P. Tan, A. Chunara, A.A. Fadzil, S.G. Wise, M.C. Kruyt, S. Wijdicks, W.E. Hennink, M.M.M. Bilek, S. Amin Yavari, A multifaceted biomimetic interface to improve the longevity of orthopedic implants, Acta Biomaterialia, 110 (2020) 266–279. https://doi.org/10.1016/j.actbio.2020.04.020
Jahanmard, F.M. Dijkmans, A. Majed, H.C. Vogely, B.C.H. van der Wal, D.A.C. Stapels, S.M. Ahmadi, T. Vermonden, and S. Amin Yavari, Toward Antibacterial Coatings for Personalized Implants, ACS Biomater. Sci. Eng., 6 (2020) 5486−5492. https://dx.doi.org/10.1021/acsbiomaterials.0c00683
M. Croes, S. Bakhshandeh, I.A.J. van Hengel, K. Lietaert, K.P.M. van Kessel, B. Pouran, B.C.H. van der Wal, H.C. Vogely, W. Van Hecke, A.C. Fluit, C.H.E. Boel, J. Alblas, A.A. Zadpoor, H. Weinans, S. Amin Yavari, Antibacterial and immunogenic behavior of silver coatings on additively manufactured porous titanium, Acta Biomaterialia, 81 (2018) 315-327. https://doi.org/10.1016/j.actbio.2018.09.051
S. Bakhshandeh, Z. Gorgin Karaji, K. Lietaert, A.C. Fluit, C.H.E. Boel, H.C. Vogely, T. Vermonden, W.E. Hennink, H. Weinans, A.A. Zadpoor, S. Amin Yavari, Simultaneous Delivery of Multiple Antibacterial Agents from Additively Manufactured Porous Biomaterials to Fully Eradicate Planktonic and Adherent Staphylococcus aureus, ACS Applied Materials and Interfaces, 9(31) (2017) 25691-25699. https://doi.org/10.1021/acsami.7b04950
Z. Gorgin Karaji, M. Speirs, S. Dadbakhsh, J.P. Kruth, H. Weinans, A.A. Zadpoor, S. Amin Yavari, Additively manufactured and surface biofunctionalized porous nitinol, ACS Applied Materials and Interfaces, 9(2) (2017) 1293- 1304. https://doi.org/10.1021/acsami.6b14026
S. Amin Yavari, L. Loozen, F.L. Paganelli, S. Bakhshandeh, K. Lietaert, J.A. Groot, A.C. Fluit, C.H.E. Boel, J. Alblas, H.C. Vogely, H. Weinans, A.A. Zadpoor, Antibacterial Behavior of Additively Manufactured Porous Titanium with Nanotubular Surfaces Releasing Silver Ions, ACS Applied Materials and Interfaces, 8(27) (2016) 17080-17089. https://doi.org/10.1021/acsami.6b03152
S. Amin Yavari, J. van der Stok, Y.C. Chai, R. Wauthle, Z. Tahmasebi Birgani, P. Habibovic, M. Mulier, J. Schrooten, H. Weinans, A.A. Zadpoor, Bone regeneration performance of surface-treated porous titanium, Biomaterials, 35(24) (2014) 6172-6181. https://doi.org/10.1016/j.biomaterials.2014.04.054