The Bijvoet Center houses advanced infrastructures for the analysis of proteins and other biomolecules using NMR, X-ray crystallography, electron microscopy and mass spectrometry and other technologies. The Bijvoet Center has a long history of providing access to their technologies and infrastructures to the Dutch, European and world-wide scientific communities.
Our high-resolution NMR spectroscopy instruments makes it possible to determine the structure of small to medium size proteins or other biomolecules. Combined with molecular dynamics, the functional interactions between biomolecules can be assessed. We use X-ray crystallography on in-house X-ray diffractometers and beam lines at the European Synchrotron in Grenoble to developed atomic resolution structures of proteins and protein complexes. Mass spectrometry is used for state-of-the art proteomics and for the structural characterization of biomolecules in relation to their biological function. Electon microscopy is used to analyse protein structures in a cellular context and light and super-resolution microscopy is employed to analyze proteins in living cells. Finally we use a wide variety of chemical and biochemical techniques in addition to structural studies to advance their understanding of the various functions of biomolecules and their interactions.
Follow the link below for more information on the different infrastructures, the technologies available, and the possiblities for access to the instrumentation and expertise: