Maintaining the natural shape of proteins is essential for life. Failure to do so is origin of lethal, incurable diseases such as Cystic Fibrosis, Alzheimer, Parkinson, ALS, or cancer. Common to those diseases are fatal distortions in protein shape. Human life therefore depends on a defense system that maintains the shape of our proteins, the strongly regulated network of chaperones and folding enzymes. Why does this network fail in disease? Our work is dedicated to the origin of protein failure diseases and the regulation and mechanisms of our natural defense systems.