The research in the Biomolecular Mass Spectrometry and Proteomics groups focuses on the use of mass spectrometry to understand the inner workings of cells. Mass spectrometry enables the characterization of molecules that are present in cells and allows thereby the identification and characterization of proteins and other biomolecules that work together and are involved in cellular processes and in disease. The group houses an excellent array of state-of-the-art mass spectrometers, combined with extensive protein and peptide separation methods. The group has a world-renown expertise in the analysis of protein-ligand, protein-protein and protein-DNA analysis by mass spectrometry. Therefore, dedicated mass spectrometers and LC methods have been and are developed allowing the analysis of the structure and function of protein machineries.
Protein Complex Topology and Dynamics