The research of the Biomolecular Mass Spectrometry and Proteomics Group at Utrecht University focuses on understanding the molecular machinery of life using state-of-the-art mass spectrometry, structural proteomics, and advanced computational tools. We develop and implement innovative mass spectrometric methods for the more efficient and detailed characterization of peptides and proteins in relation to their biological function. A large emphasis lays on the structural characterization of proteins and their post-translational modifications as well as the investigation of protein complexes and protein interactions. In short, the group applies biomolecular mass spectrometry to problems in proteomics, cell biology, biotherapeutics, immunology and in structural biology. 

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  • Proteins at work

    The collection of our proteins in ours cells is called the proteome. The proteome is the counterpart of the genome, where all information about our genes reside. Whereas the genome remains the same throughout our lives, out proteome changes. The proteome is the reason why a grown-up, flying butterfly can become so distinct from the young, crawling caterpillar it once was. 

    The study of the proteins in our cells is called proteomics. We study the proteome using mass spectrometry, determining the identify, structure and quantity of a protein, where they are in the cell and with who or what they interact. 

  • Proteomics Visualized
  • Quest for antibodies

    Antibodies are a special type of proteins in our body, with a unique structure and function. They are made to protect our body from all treats by identifying and destroying foreign invaders that enter our system, or emerge from within. In our lab, we study antibodies to gain understanding of how our immune system works, to use this knowledge our advantage to treat infectious or bacterial diseases, auto-immune disease or cancer. 

    Inspired by our antibody research, we worked together with the video performers of Sensu and the dancers of the Aerialettes, to artistically imagine how our immune system keeps us healthy. 

     

  • Prof. Albert Heck

    Professor

    Proteomics and Structural Biology

  • Prof. Maarten Altelaar

    Professor

    Novel MS Based Proteomics Technologies

  • Dr. Bas van Breukelen

    Associate Professor

    Bioinformatics Tools for Proteomics
    Coordinator Bioinformatics and BioComplexity Master's Programme and UIPS Drug Innovation PhD Programme

  • Dr. Marc Baggelaar

    Assistant Professor

    Chemical Biology and Protein Lipidation

  • Dr. Serena Di Palma

    Assistant Professor

    Education in Bachelor and Master programmes of Pharmaceutical Sciences and Molecular and Biophysical Life Sciences

  • Dr. Fabio Marino

    Assistant Professor

    Antigen Discovery and Immuno Biology

  • Dr. Pavel Sinitcyn

    Assistant Professor

    Computational Mass Spectrometry

  • Dr. Joost Snijder

    Assistant Professor

    Structural proteomics of virus-host interactions

  • Dr. Kelly Stecker

    Assistant Professor 

    Cell signaling and regulation of protein complexes