The Bijvoet Centre houses advanced infrastructures for the analysis of proteins and other biomolecules. Our high-resolution NMR spectroscopy instruments makes it possible to determine the structure of small to medium size proteins or other biomolecules. Combined with molecular dynamics, the functional interactions between biomolecules can be assessed. We use X-ray crystallography on in-house X-ray diffractometers and synchrotrons to develop atomic resolution structures of proteins and protein complexes. Mass spectrometry is used for state-of-the art proteomics and for the structural characterization of biomolecules in relation to their biological function. Electron microscopy is used to analyze protein structures in a cellular context. Finally we use a wide variety of chemical and biochemical techniques in addition to structural studies to advance their understanding of the various functions of biomolecules and their interactions.
The Bijvoet Centre is one of the access sites of Instruct-ERIC, a pan-European research infrastructure in structural biology, making high-end technologies and methods available to users. Through Instruct, European scientist from many countries, including the Netherlands, can get access to high-end structural biology technology throughout Europe.
Follow the links below for more information on the different infrastructures, the technologies available, and the possiblities for access to the instrumentation and expertise:
Electron Microscopy Centre
The centre covers the entire range of specimen preparation, electron microscopy data collection and analysis, and 3D reconstruction techniques.
National Single Crystal X-Ray Facility
The National Single Crystal X-ray Facility offers crystal structure determinations to synthetic chemists at universities, institutes and companies.
NMR Large Scale Facility
Nuclear Magnetic Resonance has the versatility to characterise different kinds of biomolecules, processes and living organisms.
Biomolecular Mass Spectrometry and Proteomics
Research on innovative mass spectrometric methods for efficient and detailed analysis of proteins in relation to their biological function.
Protein Research Centre
The Protein Research Centre is an expertise platform for protein research at Utrecht University. Providing a shared lab space for protein production, purification and characterisation. Access is available for state-of-the-art equipment for all life science researchers.