Vacancies

Open Ph.D. positions in the Baldus group:

Our group develops and applies magnetic resonance (NMR)-based approaches to unravel structure-function relationships in complex molecular systems with the goal to understand principal chemical reactions and biological processes such as signal transduction, molecular transport or (bio)catalysis. In our studies, we use a combination of cutting-edge solid-state NMR and other spectroscopic and biophysical/cell biology techniques. Currently, we offer Ph.D. positions in the following research areas:

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[1] Life at the cell surface: Ligand binding to Membrane Proteins seen in human cells @ atomic resolution

The human cell membrane houses protein receptors that interact with other molecules to stimulate specific cellular processes. In this project you will use and further develop our high-sensitivity NMR approach (Kaplan et al., Cell 2016) to study such protein receptors at the human cell surface. You will find out how how these receptors change their structure and dynamics when drugs and other ligands bind in natural 2D and 3D cell cultures.

 

[2]  Controlling bacterial life: How does protein assembly work at the bacterial cell surface?

To design novel antibiotics, we need to find new ways to control bacterial cells. The Beta-barrel assembly complex (BAM) is a vital protein machine in the bacterial outer membrane. Already, we could study this protein machine in functional bilayers (Sinnige et al., Structure, 2015  and Pinto et al., Nature Comm 2018).

In the current project you will directly study the workings of the BAM system in bacterial cells by using and further developing cellular solid-state NMR methods we pioneered in our lab. (Kaplan et al., Nature Methods 2015)

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As a PhD candidate working on the aforementioned projects, you will be part of a team working on further optimizing such studies from the level of protein/cellular preparation to NMR data acquisition and computational analysis. You will have access to state-of-the-art NMR, biophysical and cell biology infrastructures supported by research grants from the Netherlands Organization for Scientific Research (NWO) to Prof. dr. M. Baldus.

Qualifications

The successful candidate should have a Master’s or equivalent degree in chemistry, physics, or biology with a general interest in biophysics, cell biology and/or spectroscopy. Experience in NMR or a related spectroscopic method is desirable.

Terms of employment

We offer a position for four years. You are expected to have a Ph.D. thesis written by the end of the fourth year. Employment conditions are according to the Collective Labour Agreement of Dutch Universities. Next to research (90%) you are also expected to contribute to teaching (10%).

Further details

For further information contact Prof. dr. Marc Baldus (Phone: +31-30-2533801, Email:m.baldus@uu.nl)