Ph.D. positions in the Baldus group

Currently, we are searching for PhD candidates in the following fields:

 

[1]  Probing 3D molecular structure in-situ using high-sensitivity solid-state NMR

[2]  Developing and applying in-situ Solid-state NMR spectroscopy on biomaterials

 

 

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[1]  Probing 3D molecular structure in-situ using high-sensitivity solid-state NMR

Solid-state NMR is a powerful method to study molecular structure and dynamics at the most detailed (i.e., atomic) level in complex systems such as membrane or Amyloid proteins. Recently, our group has shown the use of high-sensitivity NMR to study intact cellular systems (for recent work see, e.g.,  Kaplan et al., Cell 2016 or Kaplan et al., Nature Methods 2015). These developments provide now exciting opportunities to study 3D molecular structure in a cellular context.

As a PhD candidate, you will be part of a team working on further optimizing such studies from the level of protein/cellular preparation to NMR data acquisition and analysis. You will have access to state-of-the-art NMR and biophysical infrastructures supported by research grants from the Netherlands Organization for Scientific Research (NWO) to Prof. dr. M. Baldus.

Qualifications

The successful candidate should have a Master’s or equivalent degree in chemistry, physics, or biology with a general interest in biophysics, physical chemistry and spectroscopy. Experience in NMR or a related spectroscopic method is desirable.

Terms of employment

We offer a position for four years. You are expected to have a Ph.D. thesis written by the end of the fourth year. Employment conditions are according to the Collective Labour Agreement of Dutch Universities. Next to research (90%) you are also expected to contribute to teaching (10%).

Further details

For further information contact Prof. dr. Marc Baldus (Phone: +31-30-2533801, Email:m.baldus@uu.nl)

 

 

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[2]  Developing and applying in-situ Solid-state NMR spectroscopy on biomaterials

Our group has shown the use of Dynamic Nuclear Polarization (DNP) for studying intact cellular systems (for recent work see, e.g., Kaplan et al., Nature Methods 2015 or Jantschke and Koers et al., Angewandte Chemie Int. Ed. 2015). As a PhD candidate, you will use state-of-the-art equipment available at the NMR group including DNP instruments at 400 and 800 MHz to obtain further insight into the structural organization of Diatoms which are unicellular eukaryotic microalgae that produce intricately structured cell walls made of amorphous hydrated SiO2:

You will closely work together with members of the NMR group at UU and you will be involved in regular interactions within an international team of researchers. The position is funded by a research grant of the German Research foundation (DFG) within the Research group “Nanopatterned Organic Matrices in Biological Silica Mineralization” http://www.nanomee.de/ to Prof. dr. M. Baldus.

Qualifications
The successful candidate should have a Master’s or equivalent degree in chemistry, physics, or biology with a general interest in biophysics, physical chemistry and spectroscopy. Experience in NMR or a related spectroscopic method is desirable.

Further details
For further information contact Prof. dr. Marc Baldus (Phone: +31-30-2533801, Email:m.baldus@uu.nl)