Vacancies

Open Ph.D. positions in the Baldus group:

Our group develops and applies magnetic resonance (NMR)-based approaches to unravel structure-function relationships in complex molecular systems with the goal to understand principal chemical reactions and biological processes such as signal transduction, molecular transport or (bio)catalysis. In our studies, we use a combination of cutting-edge solid-state NMR and other spectroscopic and biophysical/cell biology techniques.

If you are interested to join us as PhD student or Postdoc, please contact us anytime.

In addition, we currently offer Ph.D. positions in the following research areas:

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[1] Deciphering the molecular architecture of biomaterials @ atomic resolution

Understanding how pro- and eukaryotic microorganisms assemble into microparticles is critical for chemical and pharmaceutical research as well as for the design of new biomaterials. Our group has introduced novel NMR methods to study such systems in-situ at both structural and dynamical level (see, e.g. Renault et al. PNAS 2012, Koers et al., ACIE 2015 and Kaplan et al. Cell 2016). In this project you will use and further develop our high resolution solid-state NMR methods to study such systems at the most detailed level. You will work together with colleagues in our team and in collaboration with local and international collaborators.

[2]  Understanding liquid-liquid phase separation at atomic resolution

Increasing evidence suggests that membraneless organelles that form through a process called liquid–liquid phase separation are important in health and diseases such as neurodegenerative diseases or cancer. In our work (Ader et al, PNAS 2010, Ward et al. ChemComm 2018, Damman et al., 2019 in revision) we have shown the potential of NMR to study such dynamic systems at atomic resolution. In this project you will use and further develop such approaches including novel in-cell NMR approaches (Narasimhan et al. ACIE 2019) to obtain a complete three-dimensional view on how proteins and other biomolecules together can form such condensates in vitro and in cells. You will work together with colleagues in our team and in collaboration with local and international collaborators.

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As a PhD candidate working on the aforementioned projects, you will be part of a team working on further optimizing such studies from the level of protein/cellular preparation to NMR data acquisition and computational analysis. You will have access to state-of-the-art NMR, biophysical and cell biology infrastructures supported by research grants from the Netherlands Organization for Scientific Research (NWO) and the EU to Prof. dr. M. Baldus.

Qualifications

The successful candidate should have a Master’s or equivalent degree in chemistry, physics, or biology with a general interest in biophysics, cell biology and/or spectroscopy. Experience in NMR or a related spectroscopic method is desirable.

Terms of employment

We offer a position for four years. You are expected to have a Ph.D. thesis written by the end of the fourth year. Employment conditions are according to the Collective Labour Agreement of Dutch Universities. Next to research (90%) you are also expected to contribute to teaching (10%).

Further details

For further information contact Prof. dr. Marc Baldus (Phone: +31-30-2533801, Email:m.baldus@uu.nl)