Silvia's research is aimed at developing humanized in vitro models that replicate the topographical, cellular, flow and functional features of tissue and organs. In this pursuit, advanced cell cultures (organoids, iPSCs, stem cells) combined with bio-fabrication and organs-on-chip technology are being employed. A particular attention is dedicated to modeling the gut, bone and kidney (alone or in combination) to replicate the complex pathophysiology and comorbidities associated with kidney diseases. The ultimate goal is to unravel mechanisms of disease, identify potential therapeutical targets and screen therapeutic compounds. The kidney models are also used to evaluate in vitro nephrotoxicity of new drugs and the drug-drug interactions in disease.
She is a member of the Utrecht Young Academy, member of the Young Investigator Forum, organizer of the scientific session of Science for life event and best poster committee, member of Material Driven Regeneration (MDR) Outreach team and Committee best PhD thesis award at Dutch Society for Biomaterials and Tissue Engineering.
More information can be found on her staff page.