1. The Interspecies Database (www.interspeciesinfo.com) provides insight into physiological, anatomical and biochemical parameters of different animal species and humans. By using the database, researchers can design their experiments smarter with respect to the choice of an animal model. This could lead to a reduction in the number of experimental animals. Above all, this improves the scientific research quality. Users have indicated a reduction of on average 20% of laboratory animals annually, while some users reported a reduction of up to 40%. The website was initiated by the Dutch Institute for Public Health and the Environment (RIVM), which is responsible for the database content.