prof. dr. A.D. (Aletta) Kraneveld
A.D.Kraneveld@uu.nl
Gegenereerd op 2018-09-19 23:03:02


Profile

Aletta Kraneveld studied Pharmacy at the schools of Pharmacy at University of Amsterdam and Utrecht University. As a junior researcher she worked at the department of Gastrointestinal Pharmacology of Glaxo Group Research in the UK (1990-1991). She obtained her PhD at the department of Pharmacology, Faculty of Pharmacy, Utrecht University (1994) after which she did an internship at the department of Pathology, Harvard Medical School Boston MA, USA (PI Steve Galli). As a post doc she continued her research as immune-pharmacologist in Utrecht. In 1998 Aletta was appointed as assistant professor and in 2002 as associate professor at the division of Pharmacology of the department of Pharmaceutical Sciences of the Utrecht University. She has published 80 papers (H-index: 30). Besides science, she is an active member of several boards of (inter)national scientific organizations (Dutch Society of Pharmacology, EPHAR, IUPHAR, Netherlands Federation of Innovative Drug research).

Her current research interests involve targeting the interaction between innate and adaptive immunity as well as host-microbiome interactions in chronic (inflammatory) diseases with pharmaceutical as well as nutritional interventions. As principle investigator Aletta is focusing her research to in depth study the role of the gut-immune-brain-axis in inflammatory bowel disease, food allergy, and neurodevelopmental disorders (autism, preterm birth associated neurodevelopmental and immunological disorders) and neurodegenerative disorders (Parkinson’s disease) that will further enhance our knowledge of the interaction of innate and adaptive immune system and neurons in chronic inflammatory conditions in the gut and CNS. Aletta Kraneveld has set up a new research group within UU, where a strong collaboration with several (inter) national research institutes and industries is part of. The program is the start of a (inter)national neuro-immune platform where academia and industry meet for research on the gut-immune-brain axis as target for medicine and medical food concepts. 

Strategic themes / Focus areas
Involved in the following study programme(s)
Gegenereerd op 2018-09-19 23:03:02
Curriculum vitae Download PDF

Academic training 

2004                Course “Academic Leadership”, Utrecht University, Utrecht, The Netherlands

2002                Senior qualification Research, Utrecht University, Utrecht, The Netherlands

                        Basic qualification teaching, Utrecht University, Utrecht, The Netherlands

1990-1994       PhD, Depart of Pharmacology & Pathophysiology, Faculty of Pharmacy, Utrecht    University (supervisor Prof. Dr. Frans Nijkamp)

1983-1989       MSc Pharmacy, schools of Pharmacy of University of Amsterdam & Utrecht University, the Netherlands

Experience

2002-present   Associate Professor in Neuro-immunopharmacology, Division Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands

1998-2002       Assistant Professor in Asthma and IBD research, Department of Pharmacology and Pathophysiology, Faculty for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands

1994                Internship at the department of Pathology, Harvard Medical School Boston MA, USA (PI Porf Dr Steve Galli)

1990-1991      Junior researcher dept Gastrointetsinal Pharmacology, Glaxo Group Research (PI Dr Malcolm Johnson)

 

Other (scientific) activities

Top Institute Pharma

2007-2012       Principle investigator TIPharma project T1.103

2009-2013       Theme-leader (Auto)immune diseases TIPharma

Topsector Life Sciences & Health

2011-2013       Member roadmap-team Specialized Nutrition in Health and Disease

2011-2013       Member roadmap-team Pharmacotherapy

NWO-ZonMW

2013                Member International review committee LSH Impulse

Utrecht Life Sciences-Pharmacology

2012-2013       Member workgroup Pharmacology & Pharmacotherapy of Faculty of Sciences, Medicine and Veterinary Sciences, Utrecht University

More than 30 invited lectures; reviewer of several scientific journals; editor of ‘Fundamental and Clinical Pharmacology’ and ‘Principles of Immunopharmacology’, 4th edition; organizer of several scientific meeting (annual meeting of the Dutch Pharmacological Society; session at the 1999 ALA/ATS International Conference, San Diego USA; EPHAR workshop “New opportunities in the pharmacology of neuro-immune interactions” at WorldPharma 2010, Copenhagen, Denmark; yearly held FIGON Dutch Medicine Days scientific session at the 2015 EACPT meeting, Madrid, Spain.

Board memberships

2003-2007       Member of board of the Dutch Pharmacological Society (NVF)

2007-2011       Chair Dutch Pharmacological Society (NVF)

2008-               Member/treasurer of the Executive board the Federation of European Pharmacological Societies (EPHAR)

2008-2011       Member of board of Federatie Innovatief Geneesmiddelonderzoek Nederland

2008-2011       Member of the board of the ‘Stichting Farmaciologische wetenschappen”

2011-               Chair of Federatie Innovatief Geneesmiddelonderzoek Nederland

2012-2014       Member/chair of networkgroup Sociale Innovatie Medical Sciences of ministry of Public Health Welfare & Sports, the Netherlands

2014-               Chairperson Diversity Committee Faculty of Science, Utrecht University

Jury

2011-               Galenus Award, Foundation Galenus Award, the Netherlands

2012-2013       Sociale Innovatie Award, network group SIMS, an initiative from the ministry of Public Health Welfare & Sports, the Netherlands 

Gegenereerd op 2018-09-19 23:03:02
All publications
  2018 - Scholarly publications
Mackus, Marlou, van Schrojenstein Lantman, Marith, van de Loo, A.J.A.E., Kraneveld, A.D., Garssen, J. & Verster, J.C. (01.04.2018). Alcohol metabolism in hangover sensitive versus hangover resistant social drinkers. Drug and Alcohol Dependence, 185, (pp. 351-355).
Varasteh, Soheil, Braber, Saskia, Kraneveld, Aletta D., Garssen, Johan & Fink-Gremmels, Johanna (01.09.2018). L-Arginine supplementation prevents intestinal epithelial barrier breakdown under heat stress conditions by promoting nitric oxide synthesis. Nutrition Research, 57, (pp. 45-55) (11 p.).
  2017 - Scholarly publications
Mackus, Marlou, van de Loo, Aurora J A E, Raasveld, S. Jorinde, Hogewoning, Anna, Sastre Toraño, Javier, Flesch, Frits M, Korte-Bouws, Gerdien A H, van Neer, Renier H P, Wang, Xiaochun, Nguyen, Thomas T, Brookhuis, Karel A, Kraneveld, Aletta D, Garssen, Johan & Verster, Joris C (2017). Biomarkers of the alcohol hangover state - Ethyl glucuronide (EtG) and ethyl sulfate (EtS). Human Psychopharmacology, 32 (5). © 2017 The Authors. Human Psychopharmacology: Clinical & Experimental Published by John Wiley & Sons Ltd..
Ahmadizar, Fariba, Vijverberg, Susanne J H, Arets, Hubertus G. M., de Boer, Anthonius, Garssen, Johan, Kraneveld, Aletta D & Maitland-van der Zee, Anke H (2017). Breastfeeding is associated with a decreased risk of childhood asthma exacerbations later in life. Pediatric Allergy and Immunology, 28 (7), (pp. 649-654) (6 p.). © 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd..
Wu, Jiangbo, de Theije, Caroline G M, da Silva, Sofia Lopes, Abbring, Suzanne, van der Horst, Hilma, Broersen, Laus M, Willemsen, Linette, Kas, Martien, Garssen, Johan & Kraneveld, Aletta D (2017). Dietary interventions that reduce mTOR activity rescue autistic-like behavioral deficits in mice. Brain, Behavior, and Immunity, 59, (pp. 273-287). Copyright © 2016. Published by Elsevier Inc..
de Kivit, Sander, Kostadinova, Atanaska I, Kerperien, JoAnn, Morgan, Mary E, Muruzabal, Veronica Ayechu, Hofman, Gerard A, Knippels, Leon M J, Kraneveld, Aletta D, Garssen, Johan & Willemsen, Linette E M (2017). Dietary, nondigestible oligosaccharides and Bifidobacterium breve M-16V suppress allergic inflammation in intestine via targeting dendritic cell maturation. Journal of Leukocyte Biology, 102 (1), (pp. 105-115) (11 p.). © Society for Leukocyte Biology..
Mackus, Marlou, de Kruijff, Deborah, Otten, Leila S., Kraneveld, Aletta D, Garssen, Johan & Verster, Joris (12.04.2017). Differential Gender Effects in the Relationship between Perceived Immune Functioning and Autistic Traits. International Journal of Environmental Research and Public Health, 14 (4) (6 p.).
Ahmadizar, Fariba, Vijverberg, Susanne J H, Arets, Hubertus G M, de Boer, Anthonius, Turner, Steve, Devereux, Graham, Arabkhazaeli, Ali, Soares, Patricia, Mukhopadhyay, Somnath, Garssen, Johan, Palmer, Colin N A, de Jongste, Johan C, Jaddoe, Vincent Wv, Duijts, Liesbeth, van Meel, Evelien R, Kraneveld, Aletta D & Maitland-van der Zee, Anke H (2017). Early life antibiotic use and the risk of asthma and asthma exacerbations in children. Pediatric Allergy and Immunology, 28 (5), (pp. 430-437). This article is protected by copyright. All rights reserved..
de Kivit, Sander, Kostadinova, Atanaska I, Kerperien, JoAnn, Ayechu Muruzabal, Veronica, Morgan, Mary E, Knippels, Leon M J, Kraneveld, Aletta D, Garssen, Johan & Willemsen, Linette E M (2017). Galectin-9 Produced by Intestinal Epithelial Cells Enhances Aldehyde Dehydrogenase Activity in Dendritic Cells in a PI3K- and p38-Dependent Manner. Journal of Innate Immunity, 9 (6), (pp. 609-620) (12 p.). © 2017 S. Karger AG, Basel..
Perez-Pardo, Paula, Dodiya, Hemraj B., Broersen, Laus M, Douna, Hidde, van Wijk, Nick, Lopes da Silva, Sofia, Garssen, Johan, Keshavarzian, Ali & Kraneveld, Aletta D (09.03.2017). Gut-brain and brain-gut axis in Parkinson's disease models - Effects of a uridine and fish oil diet. Nutritional neuroscience, (pp. 1-12) (12 p.).
Lantman, Marith Van Schrojenstein, Mackus, Marlou, Otten, Leila S., de Kruijff, Deborah, van de Loo, Aurora J. A. E., Kraneveld, Aletta D., Garssen, Johan & Verster, Joris C. (21.03.2017). Mental resilience, perceived immune functioning, and health. Journal of Multidisciplinary Healthcare, 10, (pp. 107-111).
Perez-Pardo, Paula, de Jong, Esther M, Broersen, Laus M, van Wijk, Nick, Attali, Amos, Garssen, Johan & Kraneveld, Aletta D (20.03.2017). Promising Effects of Neurorestorative Diets on Motor, Cognitive, and Gastrointestinal Dysfunction after Symptom Development in a Mouse Model of Parkinson's Disease. Frontiers in aging neuroscience, 9 (12 p.).
van Schrojenstein Lantman, Marith, van de Loo, Aurora J A E, Mackus, Marlou, Kraneveld, Aletta D, Brookhuis, Karel A, Garssen, Johan & Verster, Joris C (04.12.2017). Susceptibility to Alcohol Hangovers - Not Just a Matter of Being Resilient. Alcohol and Alcoholism, (pp. 1-4) (4 p.).
Mackus, Marlou, de Kruijff, Deborah, Otten, Leila S., Kraneveld, A D, Garssen, J & Verster, J C (19.07.2017). The 2D : 4D Digit Ratio as a Biomarker for Autism Spectrum Disorder. Autism research and treatment, 2017 (5 p.).
Perez-Pardo, Paula, Kliest, Tessa, Dodiya, Hemraj B., Broersen, Laus M, Garssen, Johan, Keshavarzian, Ali & Kraneveld, Aletta D (15.12.2017). The gut-brain axis in Parkinson's disease - Possibilities for food-based therapies. European Journal of Pharmacology, 817, (pp. 86-95) (10 p.). Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved..
Zheng, Bin, Morgan, Mary E, van de Kant, Hendrik J G, Garssen, Johan, Folkerts, Gert & Kraneveld, Aletta D (2017). Transcriptional modulation of pattern recognition receptors in chronic colitis in mice is accompanied with Th1 and Th17 response. Biochemistry and biophysics reports, 12, (pp. 29-39) (11 p.).
  2016 - Scholarly publications
Rietdijk, Carmen D., de Haan, Lydia, van Wezel, Richard J. A., Garssen, Johan & Kraneveld, Aletta D. (24.02.2016). Best practice for passaging murine embryonic enteric neuronal cell line before differentiation. Cytotechnology, (pp. 1-10) (10 p.).
Alizadeh, Arash, Braber, Saskia, Akbari, Peyman, Kraneveld, Aletta, Garssen, Johan & Fink-Gremmels, Johanna (16.11.2016). Deoxynivalenol and Its Modified Forms - Are There Major Differences?. Toxins, 8 (11).
Ahmadizar, F., Vijverberg, S., Arets, H., de Boer, Anthonius, Garssen, J., Kraneveld, A.D. & Maitland-Van Der Zee, A.-H. (01.08.2016). Early life antibiotic exposure is associated with an increased risk of atopic eczema and hay fever. Allergy: European Journal of Allergy and Clinical Immunology, 71, (pp. 319) (1 p.).
Szklany, K., De Theije, C.G.M., De Waard, C., Van Staveren, N.G., Van Wageningen, T., Wu, J., Verdouw, M., Van Limpt, K., Wopereis, H., Groenink, L., Oozeer, R., Knippels, L.M.J., Garssen, J. & Kraneveld, A.D. (01.08.2016). Early life supplementation of 3% scGOS: lcGOS (9:1) leads to immuno-and neuromodulatory effects in healthy mice. Allergy: European Journal of Allergy and Clinical Immunology, 71, (pp. 291) (1 p.).
Te Velde, Anje A, Bezema, Tjitske, van Kampen, Antoine H C, Kraneveld, Aletta D, 't Hart, Bert A, van Middendorp, Henriët, Hack, Erik C, van Montfrans, Joris M, Belzer, Clara, Jans-Beken, Lilian, Pieters, Raymond H, Knipping, Karen, Huber, Machteld, Boots, Annemieke M H, Garssen, Johan, Radstake, Tim R, Evers, Andrea W M, Prakken, Berent J & Joosten, Irma (2016). Embracing Complexity beyond Systems Medicine - A New Approach to Chronic Immune Disorders. Frontiers in Immunology, 7.
Kraneveld, A D, Szklany, K, de Theije, C G M & Garssen, J (2016). Gut-to-Brain Axis in Autism Spectrum Disorders - Central Role for the Microbiome. International Review of Neurobiology, 131, (pp. 263-287) (25 p.). © 2016 Elsevier Inc. All rights reserved..
van Bergenhenegouwen, Jeroen, Kraneveld, Aletta D, Rutten, Lieke, Garssen, Johan, Vos, Arjan P & Hartog, Anita (28.10.2016). Lipoproteins attenuate TLR2 and TLR4 activation by bacteria and bacterial ligands with differences in affinity and kinetics. BMC Immunology, 17 (42).
Hovens, Iris B, van Leeuwen, Barbara L, Mariani, Massimo A, Kraneveld, Aletta D & Schoemaker, Regien G (08.02.2016). Postoperative cognitive dysfunction and neuroinflammation; Cardiac surgery and abdominal surgery are not the same. Brain, Behavior, and Immunity Copyright © 2016. Published by Elsevier Inc..
Verheijden, Kim At, Braber, Saskia, Leusink-Muis, Thea, Thijssen, Suzan, Boon, Louis, Kraneveld, Aletta D, Garssen, Johan, Folkerts, Gert & Willemsen, Linette Em (2016). Regulatory T Cell Depletion Abolishes the Protective Effect of Dietary Galacto-Oligosaccharides on Eosinophilic Airway Inflammation in House Dust Mite-Induced Asthma in Mice. Journal of Nutrition, 146 (4), (pp. 831-837). © 2016 American Society for Nutrition..
Zheng, B, van Bergenhenegouwen, J, van de Kant, H J G, Folkerts, G, Garssen, J, Vos, A P, Morgan, M E & Kraneveld, A D (2016). Specific probiotic dietary supplementation leads to different effects during remission and relapse in murine chronic colitis. Beneficial microbes, 7 (2), (pp. 205-213) (9 p.).
Verheijden, K A T, Willemsen, L E M, Braber, S, Leusink-Muis, T, Jeurink, P V, Garssen, J, Kraneveld, A D & Folkerts, G (2016). The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible oligosaccharides and Bifidobacterium breve M-16V. European Journal of Nutrition, 55 (3), (pp. 1141-1151) (11 p.).
  2015 - Scholarly publications
Verheijden, Kim A T, Willemsen, Linette E M, Braber, Saskia, Leusink-Muis, Thea, Delsing, Dianne J M, Garssen, Johan, Kraneveld, Aletta D & Folkerts, Gert (2015). Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model. Respiratory Research, 16, (pp. 17).
Perez Pardo, P., De Jong, E.M., Broersen, L.M., Attali, A., Van Wijk, N., Garssen, J., Olivier, B. & Kraneveld, A.D. (01.03.2015). Dietary interventions with strong preventive and therapeutic effects on both motor and non-motor symptoms in a mouse model of parkinson's disease. Neurodegenerative Diseases, 15, (pp. 1319) (1 p.).
de Theije, Caroline G M, van den Elsen, Lieke W J, Willemsen, Linette E M, Milosevic, Vanja, Korte-Bouws, Gerdien A H, Lopes da Silva, Sofia, Broersen, Laus M, Korte, S Mechiel, Olivier, Berend, Garssen, Johan & Kraneveld, Aletta D (2015). Dietary long chain n-3 polyunsaturated fatty acids prevent impaired social behaviour and normalize brain dopamine levels in food allergic mice. Neuropharmacology, 90, (pp. 15-22) (8 p.).
Akbari, Peyman, Braber, Saskia, Alizadeh, Arash, Verheijden, Kim, Schoterman, Margriet Hc, Kraneveld, Aletta D, Garssen, Johan & Fink-Gremmels, Johanna (2015). Galacto-oligosaccharides Protect the Intestinal Barrier by Maintaining the Tight Junction Network and Modulating the Inflammatory Responses after a Challenge with the Mycotoxin Deoxynivalenol in Human Caco-2 Cell Monolayers and B6C3F1 Mice. Journal of Nutrition, 145 (7), (pp. 1604-1613) (10 p.).
Verheijden, Kim A T, Akbari, Peyman, Willemsen, Linette E M, Kraneveld, Aletta D, Folkerts, Gert, Garssen, Johan, Fink-Gremmels, Johanna & Braber, Saskia (2015). Inflammation-induced expression of the alarmin interleukin 33 can be suppressed by galacto-oligosaccharides. International Archives of Allergy and Immunology, 167 (2), (pp. 127-136) (10 p.).
Wu, Jiangbo, de Theije, Caroline G M, da Silva, Sofia Lopes, van der Horst, Hilma, Reinders, Margot T M, Broersen, Laus M, Willemsen, Linette E M, Kas, Martien J H, Garssen, Johan & Kraneveld, Aletta D (2015). mTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits. Neuropharmacology, 97, (pp. 220-232) (13 p.). Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved..
  2014 - Scholarly publications
Verheijden, K.A.T., Willemsen, L.E.M., Braber, S., Garssen, J., Kraneveld, A.D. & Folkerts, G. (01.09.2014). A combination of fructo-oligosaccharides and Bifidobacterium breve M-16V suppresses airway resistance and inflammation in house dust mite allergic mice. Allergy: European Journal of Allergy and Clinical Immunology, 69, (pp. 467-468) (2 p.).
Bezemer, G., Van Ark, I., Leusink Muis, T., Kraneveld, A., Garssen, J. & Folkerts, G. (01.07.2014). Acetate is more effective than a glucocorticoid steroid at preventing and reducing neutrophilic airway inflammation in a cigarette smoke induced mouse model for copd. Basic and Clinical Pharmacology and Toxicology, 115, (pp. 285) (1 p.).
de Theije, Caroline G M, Wopereis, Harm, Ramadan, Mohamed, van Eijndthoven, Tiemen, Lambert, Jolanda, Knol, Jan, Garssen, Johan, Kraneveld, Aletta D & Oozeer, Raish (2014). Altered gut microbiota and activity in a murine model of autism spectrum disorders. Brain, Behavior, and Immunity, 37, (pp. 197-206) (10 p.). Copyright © 2013 Elsevier Inc. All rights reserved..
De Theije, Caroline G M, Wu, Jiangbo, Koelink, Pim J., Korte-Bouws, Gerdien A H, Borre, Yuliya, Kas, Martien J H, Lopes da Silva, Sofia, Korte, S. Mechiel, Olivier, Berend, Garssen, Johan & Kraneveld, Aletta D. (15.03.2014). Autistic-like behavioural and neurochemical changes in a mouse model of food allergy. Behavioural Brain Research, 261, (pp. 265-274) (10 p.).
De Theije, C.G.M., Borre, Y., Bartke, N., Renes, I.B., Van Elburg, R.M., Garssen, J. & Kraneveld, A. (01.10.2014). Beneficial effects of short-chain galacto-and long-chain fructo-oligosaccharides, bifidobacterium breve and glutamine on food allergy-induced behavioural changes in mice. Archives of Disease in Childhood, 99, (pp. 87) (1 p.).
Sagar, Seil, Morgan, Mary E, Chen, Si, Vos, Arjan P, Garssen, Johan, van Bergenhenegouwen, Jeroen, Boon, Louis, Georgiou, Niki A, Kraneveld, Aletta D & Folkerts, Gert (2014). Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma. Respiratory Research, 15, (pp. 46).
Zheng, Bin, van Bergenhenegouwen, Jeroen, Overbeek, Saskia, van de Kant, Hendrik J G, Garssen, Johan, Folkerts, Gert, Vos, Paul, Morgan, Mary E & Kraneveld, Aletta D (2014). Bifidobacterium breve attenuates murine dextran sodium sulfate-induced colitis and increases regulatory T cell responses. PLoS One, 9 (5), (pp. e95441).
Koelink, P.J., Overbeek, S.A., Braber, S, Morgan, M.E., Henricks, P.A.J., Abdul Roda, M., Verspaget, H.W., Wolfkamp, S.C., te Velde, A.A., Jones, C.W., Jackson, P.L., Blalock, J.E., Sparidans, R.W., Kruijtzer, J.A.W., Garssen, J., Folkerts, G. & Kraneveld, A.D. (2014). Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease. Gut, 63, (pp. 578-587) (10 p.).
Verheijden, K., Willemsen, L., Braber, S., Garssen, J., Kraneveld, A. & Folkerts, G. (01.07.2014). Dietary intervention with galactooligosaccharides is as effective or may be more effective as the treatment with the corticosteroid, budesonide, in a house dust mite-induced model of allergic asthma. Basic and Clinical Pharmacology and Toxicology, 115, (pp. 289-290) (2 p.).
van Bergenhenegouwen, Jeroen, Kraneveld, Aletta D, Rutten, Lieke, Kettelarij, Nienke, Garssen, Johan & Vos, Arjan P (2014). Extracellular vesicles modulate host-microbe responses by altering TLR2 activity and phagocytosis. PLoS One, 9 (2), (pp. e89121) (1 p.).
Van Bergenhenegouwen, J., Rutten, L., Kettelarij, N., Kraneveld, A.D., Garssen, J. & Vos, A.P. (01.09.2014). Extracellular vesicles modulate hostmicrobe responses by ligand-dependent inhibition of TLR2 activity. Allergy: European Journal of Allergy and Clinical Immunology, 69, (pp. 531-532) (2 p.).
De Theije, Caroline G M, Bavelaar, Bas M., Lopes da Silva, Sofia, Korte, Sijmen Mechiel, Olivier, Berend, Garssen, Johan & Kraneveld, Aletta D. (01.01.2014). Food allergy and food-based therapies in neurodevelopmental disorders. Pediatric Allergy and Immunology, 25 (3), (pp. 218-226) (9 p.).
De Theije, Caroline G.M., Koelink, Pim J., Korte-Bouws, Gerdien A.H., Lopes da Silva, Sofia, Korte, S. Mechiel, Olivier, Berend, Garssen, Johan & Kraneveld, Aletta D. (01.03.2014). Intestinal inflammation in a murine model of autism spectrum disorders. Brain, Behavior, and Immunity, 37, (pp. 240-247) (8 p.).
Van Heesch, Floor, Prins, Jolanda, Konsman, Jan Pieter, Korte-Bouws, Gerdien A H, Westphal, Koen G C, Rybka, Joanna, Olivier, Berend, Kraneveld, Aletta D. & Korte, S. Mechiel (15.02.2014). Lipopolysaccharide increases degradation of central monoamines - An in vivo microdialysis study in the nucleus accumbens and medial prefrontal cortex of mice. European Journal of Pharmacology, 725 (1), (pp. 55-63) (9 p.).
Wu, J., De Theije, C., Lopes Da Silva, S., Kas, M., Van Elst, K., Garssen, J. & Kraneveld, A. (01.07.2014). MTOR plays an important role in cow's milk allergy-induced behavioral and immunological deficits. Basic and Clinical Pharmacology and Toxicology, 115, (pp. 204) (1 p.).
Borre, Y.E., Panagaki, T., Koelink, P.J., Morgan, M.E., Hendriksen, H., Garssen, J., Kraneveld, A.D., Olivier, B. & Oosting, R.S. (2014). Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression. Neuropharmacology, 79, (pp. 738-749) (12 p.).
De Kivit, Sander, Morgan, Mary E., Koelink, Pim J., Zheng, Bin, Knippels, Léon, Verspaget, Hein W., Willemsen, Linette, Garssen, Johan & Kraneveld, Aletta D. (01.05.2014). Specific non-digestible oligosaccharides combined with B. Breve M-16V attenuates experimental colitis and suppress Th17 immunity potentially via regulation of galectin-4 and-9 expression in the gut. Gastroenterology, 146 (5), (pp. 638) (1 p.).
Kraneveld, A.D. & Garssen, J. (2014). Targeting (Gut)-Immune-Brain Axis with Pharmaceutical and Nutritional Concepts: Relevance for Mental and Neurological Disorders. In G. Folkerts & J. Garssen (Eds.), Pharma-Nutrition; An Overview (pp. 439-479) (41 p.). Cham New York Heidelberg Dordrecht London: Springer.
Sagar, Seil, Vos, Arjan P, Morgan, Mary E, Garssen, Johan, Georgiou, Niki A, Boon, Louis, Kraneveld, Aletta D & Folkerts, Gert (2014). The combination of Bifidobacterium breve with non-digestible oligosaccharides suppresses airway inflammation in a murine model for chronic asthma. Biochimica et Biophysica Acta, 1842 (4), (pp. 573-83) (11 p.). Copyright © 2014 Elsevier B.V. All rights reserved..
Kraneveld, Aletta D., de Theije, Caroline G.M., van Heesch, Floor, Borre, Yuliya, de Kivit, Sander, Olivier, Berend, Korte, Mechiel & Garssen, Johan (01.01.2014). The neuro-immune axis: Prospect for novel treatments for mental disorders. Basic and Clinical Pharmacology and Toxicology, 114 (1), (pp. 128-136) (9 p.).
Verheijden, Kim, Willemsen, L.E.M., Braber, S., Garssen, J., Kraneveld, A.D. & Folkerts, G. (01.09.2014). The preventive effects of dietary galacto-oligosaccharides in a house dust mite-induced asthma model in mice. Allergy: European Journal of Allergy and Clinical Immunology, 69, (pp. 467) (1 p.).
Perez Pardo, P., Wijnands, T., Lopes Da Silva, S., Forsyth, C., Dodiya, H., Garssen, J., Keshavarzian, A. & Kraneveld, A. (01.07.2014). The role of toll like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Basic and Clinical Pharmacology and Toxicology, 115, (pp. 156-157) (2 p.).
Perez-Pardo, Paula, Douna, Hidde, Wijnands, Tom, Da Silva, Sofia Lopes, Forsyth, Christopher B., Dodiya, Hemraj B., Garssen, Johan, Olivier, Berend, Keshavarzian, Ali & Kraneveld, Aletta D. (01.05.2014). The role of toll-like receptor-4 in gut-brain cross talk in a murine model of parkinson's disease. Gastroenterology, 146 (5), (pp. 59) (1 p.).
Morgan, M E, Koelink, P J, Zheng, B, den Brok, M H M G M, van de Kant, H J G, Verspaget, H W, Folkerts, G, Adema, G J & Kraneveld, A D (2014). Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastrointestinal-associated lymphoid tissue and modulates murine experimental colitis. Mucosal Immunology, 7 (5), (pp. 1266-77) (12 p.).
  2013 - Scholarly publications
Sagar, S., Morgan, M.E., Vos, P., Garssen, J., Van Bergenhenegouwen, J., Georgiou, N., Kraneveld, A. & Folkerts, G. (01.01.2013). Bifidobacterium breve treatment is as effective as budesonide at reducing inflammation in a murine model of chronic asthma. Annals of Nutrition and Metabolism, 63, (pp. 1717) (1 p.).
Overbeek, Saskia A., Kleinjan, Marije, Henricks, Paul A.J., Kamp, Vera M., Ricciardolo, Fabio L., Georgiou, Niki A., Garssen, Johan, Kraneveld, Aletta D. & Folkerts, Gert (01.01.2013). Chemo-attractant N-acetyl proline-glycine-proline induces CD11b/CD18-dependent neutrophil adhesion. Biochimica et Biophysica Acta - General Subjects, 1830 (1), (pp. 2188-2193) (6 p.).
Overbeek, Saskia A., Braber, Saskia, Koelink, Pim J., Henricks, Paul A. J., Mortaz, Esmaeil, LoTam Loi, Adele T., Jackson, Patricia L., Garssen, Johan, Wagenaar, Gerry T. M., Timens, Wim, Koenderman, Leo, Blalock, J. Edwin, Kraneveld, Aletta D. & Folkerts, Gert (31.01.2013). Cigarette Smoke-Induced Collagen Destruction; Key to Chronic Neutrophilic Airway Inflammation?. PLoS One, 8 (1) (1 p.).
De Kivit, S., Kerperien, J., Morgan, M.E., Kostadinova, A.I., Bouwknegt, K., Hofman, G.A., Van Esch, B.C.A.M., Knippels, L.M.J., Kraneveld, A.D., Willemsen, L.E.M. & Garssen, J. (01.09.2013). Dietary intervention with specific nondigestible oligosaccharides and Bifidobacterium breve M-16V support the development of tolerogenic DC. Allergy: European Journal of Allergy and Clinical Immunology, 68, (pp. 94) (1 p.).
Sagar, S., Verheijden, K.A.T., Georgiou, N.A., Garssen, J., Kraneveld, A.D., Vos, A.P & Folkerts, G. (2013). Differential regulation of inflammation and immunity in mild and severe experimental asthma. Mediators of Inflammation, 2013 (1 p.).
Rijnierse, A., Kraneveld, A.D., Salemi, A., Zwaneveld, S., Goumans, A.P., Rychter, J., Thio, M., Redegeld, F.A.M., Westerink, R.H.S. & Kroese, A.B.A. (2013). Immunoglobulinfree light chains reduce in an antigen-specific manner the rate of rise of action potentials of mouse non-nociceptive dorsal root ganglion neurons. Journal of Neuroimmunology, 264 (1-2), (pp. 14-23) (10 p.).
De Kivit, Sander, Kraneveld, Aletta D., Knippels, Leon M.J., Van Kooyk, Yvette, Garssen, Johan & Willemsen, Linette E.M. (01.11.2013). Intestinal epithelium-derived galectin-9 is involved in the immunomodulating effects of nondigestible oligosaccharides. Journal of Innate Immunity, 5 (6), (pp. 625-638) (14 p.).
Van Heesch, Floor, Prins, Jolanda, Konsman, Jan Pieter, Westphal, Koen G C, Olivier, Berend, Kraneveld, Aletta D. & Korte, S. Mechiel (01.03.2013). Lipopolysaccharide-induced anhedonia is abolished in male serotonin transporter knockout rats - An intracranial self-stimulation study. Brain, Behavior, and Immunity, 29, (pp. 98-103) (6 p.).
Morgan, Mary E., Zheng, Bin, Koelink, Pim J., van de Kant, Hendrick J. G., Haazen, Lizette C. J. M., van Roest, Manon, Garssen, Johan, Folkerts, Gert & Kraneveld, Aletta D. (25.07.2013). New Perspective on Dextran Sodium Sulfate Colitis: Antigen-Specific T Cell Development during Intestinal Inflammation. PLoS One, 8 (7).
De Theije, C.G.M., Milosevic, V., Korte-Bouws, G.A., Van Den Elsen, L.W.J., Lopes Da Silva, S., Garssen, J., Korte, S.M. & Kraneveld, A.D. (01.09.2013). Polyunsaturated Omega-3 fatty acids restore reduced social interaction and dopaminergic activity in the prefrontal cortex of cow's milk allergic mice. Allergy: European Journal of Allergy and Clinical Immunology, 68, (pp. 557-558) (2 p.).
Van Heesch, Floor, Prins, Jolanda, Korte-Bouws, Gerdien A H, Westphal, Koen G C, Lemstra, Suzanne, Olivier, Berend, Kraneveld, Aletta D. & Korte, S. Mechiel (15.09.2013). Systemic tumor necrosis factor-alpha decreases brain stimulation reward and increases metabolites of serotonin and dopamine in the nucleus accumbens of mice. Behavioural Brain Research, 253, (pp. 191-195) (5 p.).
van Bergenhenegouwen, Jeroen, Plantinga, Theo S, Joosten, Leo A B, Netea, Mihai G, Folkerts, Gert, Kraneveld, Aletta D, Garssen, Johan & Vos, Arjan P (2013). TLR2 & Co - a critical analysis of the complex interactions between TLR2 and coreceptors. Journal of Leukocyte Biology, 94 (5), (pp. 885-902) (18 p.).
Zheng, B., Morgan, M.E., van de Kant, H.J.G., Garssen, J., Folkerts, G. & Kraneveld, A.D. (2013). Transcriptional modulation of pattern recognition receptors in acute colitis in mice. Biochimica et Biophysica Acta, 1832 (12), (pp. 2162-2172) (11 p.).
Sagar, S., Morgan, M.E., Garssen, J., Georgiou, N., Kraneveld, A.D., Folkerts, G. & Vos, A.P. (01.09.2013). Treatment with a synbiotic concept reduces asthma-like symptoms and induces regulatory responses in a murine model of chronic allergic asthma. Allergy: European Journal of Allergy and Clinical Immunology, 68, (pp. 669) (1 p.).
  2013 - Professional publications
Korte, S.M., van Heesch, F., Prins, J., Oosting, R.S., Kraneveld, A.D., Garssen, J. & Olivier, B. (2013). Overenthousiast immuunsysteem pakt ongelukkig uit. Neuropraxis, 17 (6), (pp. 161-166) (6 p.).
  2012 - Scholarly publications
Braber, S., Thio, M., Blokhuis, B.R.J., Henricks, P.A.J., Koelink, P.J., Groot Kormelink, T., Bezemer, G.F.G., Kerstjens, H.A.M., Postma, D.S., Garssen, J., Kraneveld, A.D., Redegeld, F.A.M. & Folkerts, G. (2012). An association between neutrophils and immunoglobulin free light chains in the pathogenesis of chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 185 (8), (pp. 817-24) (8 p.).
Koelink, Pim J., Overbeek, Saskia A., Braber, Saskia, Morgan, Mary E., Henricks, Paul A., Verspaget, Hein W., Wolfkamp, Simone C., Te Velde, Anje A., Jackson, Patricia L., Blalock, J. Edwin, Garssen, Johan, Folkerts, Gert & Kraneveld, Aletta D. (01.05.2012). Collagen proteolysis is important in neutrophilic intestinal auto-inflammation found in inflammatory bowel disease via proline-glycine-proline. Gastroenterology, 142 (5), (pp. 883) (1 p.).
Akbari, P., Braber, S., Kraneveld, A.D., Garssen, J. & Fink-Gremmels, J. (01.10.2012). Deoxynivalenol impairs the intestinal barrier by disrupting the tight junction network. Journal of Veterinary Pharmacology and Therapeutics, 35, (pp. 93) (1 p.).
De Theije, Caroline, Milosevic, Vanja, Korte-Bouws, Gerdien, Van Den Elsen, Lieke, Da Silva, Sofia Lopes, Korte, Mechiel, Olivier, Berend, Garssen, Johan & Kraneveld, Aletta (15.12.2012). Dietary intervention with omega-3 polyunsaturated fatty acids restores decreased dopaminergic activity in the prefrontal cortex of cow's milk allergic mice. Journal of Neuroimmunology, 253 (1-2), (pp. 57) (1 p.).
Sagar, S., Verheijden, K.A.T., Kraneveld, A.D., Georgiou, N., Garssen, J. & Folkerts, G. (01.01.2012). Different toll-like receptors (TLRs) and nod-like receptors (NLRs) expression profiles in lung tissue during mild and severe experimental asthma. American Journal of Respiratory and Critical Care Medicine, 185.
de Kivit, S, Saeland, E., Kraneveld, A.D., Van De Kant, H.J.G., Schouten, B., Van Esch, B.C.A.M., Knol, J., Sprikkelman, A.B., Van Der Aa, L.B., Knippels, L.M.J., Garssen, J., Van Kooyk, Y. & Willemsen, L.E.M. (01.03.2012). Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans. Allergy: European Journal of Allergy and Clinical Immunology, 67 (3), (pp. 343-352) (10 p.).
De Kivit, Sander, Saeland, Eirikur, Kraneveld, Aletta D., Van De Kant, Henk, Schouten, Bastiaan, Van Esch, Betty C., Knol, Jan, Sprikkelman, Aline B., Van Der Aa, Leontien B., Knippels, Léon, Van Kooyk, Yvette, Garssen, Johan & Willemsen, Linette (01.05.2012). Galectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humans. Gastroenterology, 142 (5), (pp. 394) (1 p.).
Braber, S., Akbari, P., Kraneveld, A.D., Folkerts, G., Garssen, J. & Fink-Gremmels, J. (01.10.2012). Oligosaccharides: A promising new approach for minimizing the pathological effects of deoxynivalenol on the intestinal tract. Journal of Veterinary Pharmacology and Therapeutics, 35, (pp. 49-50) (2 p.).
Sagar, Seil, Kraneveld, Aletta D., Georgiou, Niki A., Garssen, Johan & Folkerts, Gert (01.09.2012). Probiotics and synbiotics: Effects on chronic asthma in mice. European Respiratory Journal, 40.
Sagar, S., Georgiou, N.A., Folkerts, G., Garssen, J. & Kraneveld, A.D. (2012). Role of Toll-Like Receptors in Asthma. Toll-Like Receptors in Diseases of the Lung (pp. 26-45) (20 p.).
Koelink, P.J., Overbeek, S.A., Braber, S., de Kruijf, P, Folkerts, G., Smit, M.J. & Kraneveld, A.D. (2012). Targeting chemokine receptors in chronic inflammatory diseases: an extensive review. Pharmacology and Therapeutics, 133 (1), (pp. 1-18) (18 p.).
Kraneveld, Aletta D, Sagar, Seil, Garssen, Johan & Folkerts, Gert (2012). The two faces of mast cells in food allergy and allergic asthma - the possible concept of Yin Yang. Biochimica et Biophysica Acta, 1822 (1), (pp. 93-9) (7 p.). Copyright © 2011 Elsevier B.V. All rights reserved..
  2011 - Scholarly publications
Zheng, B., Morgan, M.E., Van De Kant, H.J.G., Garssen, Johan, Folkerts, G. & Kraneveld, A.D. (01.09.2011). A survey of pathogen recognition receptors in the dextran sodium sulfate-induced mouse colitis model. European Journal of Pharmacology, 668, (pp. 28-29) (2 p.).
Van Bergenhenegouwen, J., Verheijden, Kim, Garssen, J., Kraneveld, A.D. & Folkerts, G. (01.09.2011). Bifidobacterium breve and Lactobacillus rhamnosus prevent endotoxin-induced lung emphysema in mice. European Journal of Pharmacology, 668, (pp. 31-32) (2 p.).
Overbeek, S.A., Braber, S., Henricks, P.A.J., Kleinjan, M., Kamp, V.M., Georgiou, N.A., Garssen, J., Kraneveld, A.D. & Folkerts, G. (2011). Cigarette smoke induces beta2-integrin-dependent neutrophil migration across human endothelium. Respiratory Research, 12, (pp. 75) (1 p.).
Mortaz, E., Henricks, P.A.J., Kraneveld, A.D., Ezzati Givi, Nahid, Garssen, J. & Folkerts, G. (01.09.2011). Cigarette smoke induces the release of CXCL-8 from human bronchial epithelial cells via TLRs and induction of the inflammasome. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1812 (9), (pp. 1104-1110) (7 p.).
Overbeek, Saskia A, Braber, Saskia, Henricks, Paul A J, Kleinjan, Marije, Kamp, Vera M, Georgiou, Niki A, Garssen, Johan, Kraneveld, Aletta D & Folkerts, Gert (01.01.2011). Cigarette smoke induces β2-integrin-dependent neutrophil migration across human endothelium. Respiratory Research, 12, (pp. 75) (1 p.).
Braber, Saskia, Koelink, Pim J., Henricks, Paul A. J., Jackson, Patricia L., Nijkamp, Frans P., Garssen, Johan, Kraneveld, Aletta D., Blalock, J. Edwin & Folkerts, Gert (01.02.2011). Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown. American Journal of Physiology - Lung Cellular and Molecular Physiology, 300 (2), (pp. L255-L265) (11 p.).
Braber, Saskia, Overbeek, Saskia A., Koelink, Pim J., Henricks, Paul A.J., Zaman, Guido J.R., Garssen, Johan, Kraneveld, Aletta D. & Folkerts, Gert (15.10.2011). CXCR2 antagonists block the N-Ac-PGP-induced neutrophil influx in the airways of mice, but not the production of the chemokine CXCL1. European Journal of Pharmacology, 668 (3), (pp. 443-449) (7 p.).
De Kivit, Sander, Saeland, Eirikur, Kraneveld, Aletta D., Van De Kant, Henk J. G., Schouten, Bastiaan, Van Esch, Betty C. A. M., Knol, Jan, Sprikkelman, Aline B., Van Der Aa, Leontien B., Nauta, Alma J., Knippels, Léon M. J., Van Kooyk, Yvette, Garssen, Johan & Willemsen, Linette E. M. (01.09.2011). Dietary intervention with synbiotics protects against allergic disease via induction of galectin-9 by intestinal epithelial cells. Internal Medicine Journal, 41 (Suppl. 4), (pp. 13) (1 p.).
de Kivit, S., Kraneveld, A.D., Garssen, J. & Willemsen, L.E.M. (2011). Glycan recognition at the interface of the intestinal immune system: Target for immune modulation via dietary components. European Journal of Pharmacology, 668 Suppl, (pp. S124-32) (9 p.).
Crielaard, B.J., Lammers, T., Morgan, M.E., Chaabane, L., Carboni, S., Greco, B., Zaratin, P., Kraneveld, A.D. & Storm, G. (2011). Macrophages and liposomes in inflammatory disease: friends or foes?. International Journal of Pharmaceutics, 416 (2), (pp. 499-506) (8 p.).
Van Den Elsen, L., Nusse, Y., Schouten, B., Balvers, M., Redegeld, F., Kraneveld, A., Knol, E., Garssen, J. & Willemsen, L. (01.06.2011). N-3 polyunsaturated fatty acids reduce allergic type mediator release by human mast cells in vitro via inhibition of reactive oxygen species. Allergy: European Journal of Allergy and Clinical Immunology, 66, (pp. 122) (1 p.).
Overbeek, S.A., Henricks, P.A.J., Srienc, A.I., Koelink, P.J., de Kruijf, P, Lim, H.D., Smit, M.J., Zaman, G.J.R., Garssen, J., Nijkamp, F.P., Kraneveld, A.D. & Folkerts, G. (2011). N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release. European Journal of Pharmacology, 668 (3), (pp. 428-34) (7 p.).
Verheijden, K.A.T., Van Bergenhenegouwen, J., Garssen, J., Bezemer, G.F.G., Kraneveld, A.D. & Folkerts, G. (01.09.2011). Treatment with specific prebiotics or probiotics prevents the development of lung emphysema in a mouse model of COPD. European Journal of Pharmacology, 668, (pp. 12-13) (2 p.).
  2010 - Scholarly publications
Braber, S., Verheijden, K.A.T., Henricks, P.A.J., Kraneveld, A.D. & Folkerts, G. (2010). A comparison of fixation methods on lung morphology in a murine model of emphysema. American Journal of Physiology - Lung Cellular and Molecular Physiology, 299 (6), (pp. L843-51) (9 p.).
De Kivit, S., Saeland, E., Kraneveld, A., Van Kooyk, Y., Garssen, J. & Willemsen, L. (01.06.2010). A potential role for galectins in immune modulation upon exposure of human intestinal epithelial cells to non-digestible carbohydrates and TLR ligands. Allergy: European Journal of Allergy and Clinical Immunology, 65, (pp. 22-23) (2 p.).
Mortaz, E., Adcock, I.M., Ito, K., Kraneveld, A.D., Nijkamp, F.P. & Folkerts, G. (2010). Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor. European Respiratory Journal, 36 (5), (pp. 1143-54) (12 p.).
Folkerts, Gert, Blalock, E., Braber, S., Kraneveld, A. & Nijkamp, F. (01.07.2010). CXC chemokines and antagonists in chronic airway inflammation. Basic and Clinical Pharmacology and Toxicology, 107, (pp. 35-36) (2 p.).
De Kruijf, P., Koelink, P., Zheng, B., Folkerts, G., Leurs, R., Chazot, P.L., Lethbridge, N.L., Kraneveld, A.D. & Smit, M.J. (01.11.2010). Expression profiling of chemotactic receptors in inflammatory diseases. Inflammation Research, 59, (pp. 347) (1 p.).
Rijnierse, Anneke, Redegeld, Frank A., Blokhuis, Bart R., Van Der Heijden, Maurice W., Te Velde, Anje A., Pronk, Inge, Hommes, Daniel W., Nijkamp, Frans P., Koster, Andries S. & Kraneveld, Aletta D. (01.07.2010). Ig-free light chains play a crucial role in murine mast cell-dependent colitis and are associated with human inflammatory bowel diseases. Journal of Immunology, 185 (1), (pp. 653-659) (7 p.).
Braber, S., Henricks, P.A.J., Nijkamp, F.P., Kraneveld, A.D. & Folkerts, G. (2010). Inflammatory changes in the airways of mice caused by cigarette smoke exposure are only partially reversed after smoking cessation. Respiratory Research, 11 (99), (pp. 1-11) (11 p.).
Van Den Elsen, L., Schouten, B., Balvers, M., Redegeld, F., Kraneveld, A., Knol, E., Garssen, J. & Willemsen, L. (01.06.2010). Poly-unsaturated fatty acids alter the phenotype of human mast cells in vitro. Allergy: European Journal of Allergy and Clinical Immunology, 65, (pp. 494) (1 p.).
de Kruijf, P, Lim, H.D., Overbeek, S.A., Zaman, G.J.R., Kraneveld, A.D., Folkerts, G., Leurs, R. & Smit, M.J. (2010). The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2. European Journal of Pharmacology, 643 (1), (pp. 29-33) (5 p.).
  2009 - Scholarly publications
Mortaz, E., Lazar, Z., Koenderman, L., Kraneveld, A.D., Nijkamp, F.P. & Folkerts, G. (2009). Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of CXCL8 in response to TLR-9 stimulation. Respiratory Research, 10, (pp. 47) (9 p.).
Mortaz, Esmaeil, Lazar, Zsofia, Koenderman, Leo, Kraneveld, Aletta D., Nijkamp, Frans P. & Folkerts, Gert (10.06.2009). Cigarette smoke attenuates the production of cytokines by human plasmacytoid dendritic cells and enhances the release of IL-8 in response to TLR-9 stimulation. Respiratory Research, 10.
Sarir, H., Mortaz, E., Karimi, K., Kraneveld, A.D., Rahman, I, Caldenhoven, E., Nijkamp, F.P. & Folkerts, G. (2009). Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages. Journal of Inflammation, 6 (9 p.).
Morgan, M.E., Zheng, B., Ossendorp, F., Nijkamp, F.P., Garssen, J. & Kraneveld, A. (01.09.2009). Dissecting the involvement of toll-like receptors in the induction of IBD. Naunyn-Schmiedeberg's Archives of Pharmacology, 380 (3), (pp. 267) (1 p.).
Mortaz, Esmaeil, Kraneveld, Aletta D, Smit, Joost J, Kool, Mirjam, Lambrecht, Bart N, Kunkel, Steven L, Lukacs, Nicholas W, Nijkamp, Frans P & Folkerts, Gert (2009). Effect of cigarette smoke extract on dendritic cells and their impact on T-cell proliferation. PLoS One, 4 (3), (pp. 3) (9 p.).
Rijnierse, Anneke, Kroese, Alfons B.A., Redegeld, Frank A., Blokhuis, Bart R.J., van der Heijden, Maurice W., Koster, Andries S., Timmermans, Jean-Pierre, Nijkamp, Frans P. & Kraneveld, Aletta D. (31.03.2009). Immunoglobulin-free light chains mediate antigen-specific responses of murine dorsal root ganglion neurons. Journal of Neuroimmunology, 208 (1-2), (pp. 80-86) (7 p.).
Rijnierse, A., Redegeld, F.A., Blokhuis, B.R., Van Der Heijden, M.W., Te Velde, A.A., Pronk, I., Hommes, D.W., Santos, J., Guilarte, M., Nijkamp, F.P., Koster, A.S. & Kraneveld, A.D. (01.02.2009). Indication for clinical relevance of immunoglobulin-free light chains in inflammatory bowel disease and irritable bowel syndrome. Naunyn-Schmiedeberg's Archives of Pharmacology, 379 (2), (pp. 210) (1 p.).
  2008 - Scholarly publications
Kraneveld, A.D., Rijnierse, A., Nijkamp, F.P. & Garssen, J. (13.05.2008). Neuro-immune interactions in inflammatory bowel disease and irritable bowel syndrome - Future therapeutic targets. European Journal of Pharmacology, 585 (2-3), (pp. 361-374) (14 p.).
Folkerts, G., Kraneveld, A.D. & Nijkamp, F.P. (2008). New endogenous CXC chemokine ligands as potential targets in lung emphysema. Trends in Pharmacological Sciences, 29 (4), (pp. 181-185) (4 p.).
  2007 - Scholarly publications
Rijnierse, A., Nijkamp, F.P. & Kraneveld, A.D. (2007). Mast cells and nerves tickle in the tummy. Implications for inflammatory bowel disease and irritable bowel syndrome. Pharmacology and Therapeutics, 116, (pp. 207-235) (28 p.).
van Houwelingen, A.H., Kaczynska, K, Kraneveld, A.D., Kool, M., Nijkamp, F.P. & Redegeld, F.A.M. (2007). Topical application of F991, an immunoglobulin free light chain antagonist, prevents development of contact sensitivity in mice. Clinical and Experimental Allergy, 37, (pp. 270-275) (6 p.).
  2006 - Scholarly publications
Weathington, N.M., van Houwelingen, A.H., Noerager, B.D., Jackson, P.L., Kraneveld, A.D., Galin, F.S., Folkerts, G., Nijkamp, F.P. & Blalock, J.E. (2006). A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation. Nature Medicine, 12 (3), (pp. 317-323) (7 p.).
Rijnierse, A., Zijl, K., Koster, A.S., Nijkamp, F.P. & Kraneveld, A.D. (2006). Beneficial effect of tachykinin NK1 receptor antagonism in the development of hapten-induced colitis in mice. European Journal of Pharmacology, 548, (pp. 150-157) (8 p.).
Rijnierse, A., Koster, A.S., Nijkamp, F.P. & Kraneveld, A.D. (2006). Critical Role for Mast Cells in the Pathogenesis of 2,4-Dinitrobenzene-Induced Murine Colonic Hypersensitivity Reaction. Journal of Immunology, 176, (pp. 4375-4384) (10 p.).
van der Heijden, M.W., Kraneveld, A.D. & Redegeld, F.A.M. (2006). Free immunoglobulin light chains as target in the treatment of chronic inflammatory diseases. European Journal of Pharmacology, 533, (pp. 319-326) (7 p.).
Rijnierse, A., Koster, A.S., Nijkamp, F.P. & Kraneveld, A.D. (2006). TNF-alpha is crucial for the development of mast cell-dependent colitis in mice. American Journal of Physiology - Gastrointestinal and Liver Physiology, 291, (pp. G969-G976) (8 p.).
  2006 - Professional publications
Redegeld, F.A.M., van der Heijden, M.W., Kool, M., Blokhuis, B.R.J., Kraneveld, A.D. & Nijkamp, F.P. (2006). Immunoglobulin free light chains in immediate and delayed type hypersensitivity reactions. In Lowenstein, Bienenstock & Ring (Eds.), From genes to pheotype, Proceedings of the 25th Symposium of the Collegium Internationale Allergologicum Gottingen, Germany: Hogrefe and Huber.
  2005 - Scholarly publications
Kraneveld, A.D., Kool, M., van Houwelingen, A.H., Roholl, P., Solomon, A., Postma, D.S., Nijkamp, F.P. & Redegeld, F.A.M. (2005). Elicitation of allergic asthma by immunoglobulin free light chains SO. Proceedings of the National Academy of Sciences of the United States of America, 102 (5), (pp. 1578-1583) (6 p.).
  2004 - Scholarly publications
Redegeld, F.A.M., van der Heijden, M.W., Kool, M., Kraneveld, A.D. & Nijkamp, F.P. (2004). 1. Histamine in allergy, inflammation, tissue growth and repair. Functional role for Ig free light chains in immediate and delayed hypersensitivity responses. Inflammation Research, 53 (Suppl. 1), (pp. S06-S08) (3 p.).
van der Kleij, J.P.M., Kraneveld, A.D., van Houwelingen, A.H., Kool, M., Weitenberg, A.C.D., Redegeld, F.A.M. & Nijkamp, F.P. (2004). Murine model for non-IgE-mediated asthma. Inflammation, 28, (pp. 115-125) (11 p.).
  2003 - Scholarly publications
van der Kleij, H.P., Ma, D., Redegeld, F.A.M., Kraneveld, A.D., Nijkamp, F.P. & Bienenstock, J. (2003). Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factor. Journal of Immunology, 171, (pp. 2074-2079) (6 p.).
van der Kleij, H.P., Kraneveld, A.D., Redegeld, F.A.M., Gerard, N.P., Morteau, O. & Nijkamp, F.P. (2003). The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness. European Journal of Pharmacology, 476, (pp. 249-255) (7 p.).
  2002 - Scholarly publications
van Houwelingen, A.H., Kraneveld, A.D. & Nijkamp, F.P. (2002). Hapten-induced hypersensitivity reactions in the airways: atopic versus non-atopic. Environmental Toxicology and Pharmacology, 11, (pp. 197-205) (8 p.).
van Houwelingen, A.H., de Jager, S.C.A., Kool, M., van Heuven-Nolsen, D., Kraneveld, A.D. & Nijkamp, F.P. (2002). Hypersensitivity reactions in mouse airways after a single and a repeated hapten challenge. Inflammation Research, 51, (pp. 63-68) (6 p.).
Redegeld, F.A.M., van der Heijden, M.W., Kool, M., Heijdra, B.M., Garssen, J., Kraneveld, A.D., van Loveren, H., Roholl, P., Saito, T., Verbeek, J.S., Claassens, J., Koster, A.S. & Nijkamp, F.P. (2002). Immunoglobulin-free light chains elicit immediate hypersensitivity-like responses. Nature Medicine, 8 (7), (pp. 694-701) (8 p.).
Kraneveld, A.D., van der Kleij, J.P.M., Kool, M., van Houwelingen, A.H., Weitenberg, A.C.D., Redegeld, F.A.M. & Nijkamp, F.P. (2002). Key role for mast cells in nonatopic asthma. Journal of Immunology, 169, (pp. 2044-2053) (10 p.).
van Houwelingen, A.H., Kool, M., de Jager, S.C.A., Redegeld, F.A.M., van Heuven-Nolsen, D., Kraneveld, A.D. & Nijkamp, F.P. (2002). Mast cell-derived TNF alpha primes sensory nerve endings in a pulmonary hypersensitivity reaction. Journal of Immunology, 168, (pp. 5297-5302) (6 p.).
Rijnierse, A., Koster, A.S., Nijkamp, F.P. & Kraneveld, A.D. (2002). TNFalfa is crucial for the development of mast-cell dependent colitis in mice. American Journal of Physiology - Gastrointestinal and Liver Physiology, 291, (pp. G969-976) (8 p.).
  2002 - Professional publications
van der Kleij, J.P.M., Kraneveld, A.D., Redegeld, F.A.M., Bienenstock, J. & Nijkamp, F.P. (2002). Mast cell-nerve interactions in asthma. Pulmonair, 4, (pp. 11) (1 p.).
  2001 - Scholarly publications
Kraneveld, A.D. & Nijkamp, F.P. (2001). Tachykinins and neuro-immune interactions in asthma. International Immunopharmacology, 1, (pp. 1629-1650) (22 p.).
  2000 - Scholarly publications
de Bie, J.J., Kneepkens, M., Kraneveld, A.D., Jonker, E.H., Henricks, P.A.J., Nijkamp, F.P. & van Oosterhout, A.J.M. (2000). Absence of late airway response despite increased airway responsiveness and eosinophilia in a murine model of asthma. Experimental Lung Research, 26, (pp. 491-507) (17 p.).
Kraneveld, A.D., James, D.E., de Vries, A. & Nijkamp, F.P. (2000). Excitatory non-adrenergic-non-cholinergic neuropeptides: key players in asthma. European Journal of Pharmacology, 405, (pp. 113-129) (17 p.).
Redegeld, F.A.M., Kraneveld, A.D. & Nijkamp, F.P. (2000). Role of mast cells in nonallergic asthma. European Respiratory Review, 10 (73), (pp. 307-308) (2 p.).
  1999 - Scholarly publications
Roffel, A.F., Kraneveld, A.D. & Blankesteijn, W.M. (11.02.1999). Dutch Pharmacological Society Meeting, Lunteren, The Netherlands. In A.F. Roffel, A.D. Kraneveld & W.M. Blankesteijn (Eds.), Dutch Pharmacological Society Meeting (pp. 43-61) (19 p.). Dutch Pharmacological Society Meeting Lunteren, The Netherlands.
van Houwelingen, A.H., van der Avoort, L.A., van Heuven-Nolsen, D., Kraneveld, A.D. & Nijkamp, F.P. (1999). Repeated challenge with dinitrobenzene sulphonic acid in dinitrofluorobenzene-sensitized animals results in vascular hyperpermeability in the trachea: a role for tachykinins. British Journal of Pharmacology, 127, (pp. 1583-1588) (6 p.).
  1998 - Scholarly publications
Kraneveld, A D, Folkerts, G, Van Oosterhout, A J & Nijkamp, F P (24.06.1998). Airway hyperresponsiveness - first eosinophils and then neuropeptides. International Journal of Immunopharmacology, 19 (9-10), (pp. 517-27) (11 p.).
Folkerts, G., Kraneveld, A.D., van Oosterhout, A.J.M. & Nijkamp, F.P. (1998). Mast cells, eosinophils and NANC-nerves in viral respiratory tract infections. European Respiratory Review, 64, (pp. 1111-1121) (11 p.).
Kraneveld, A.D., Muis, T., Koster, A.S. & Nijkamp, F.P. (1998). Role of mucosal mast cells in early vascular permeability changes of intestinal DTH reaction in the rat. American Journal of Physiology - Gastrointestinal and Liver Physiology, 274, (pp. G832-G839) (8 p.).
  1997 - Scholarly publications
Kraneveld, A.D., van Ark, I., van der Linde, H.J., Fattah, D., Nijkamp, F.P. & van Oosterhout, A.J.M. (1997). Antibody to very late activation antigen 4 prevents interleukin-5-induced airway hyperresponsiveness and eosinophil infiltration in the airways of guinea pigs. Journal of Allergy and Clinical Immunology, 100, (pp. 242-250) (9 p.).
Kraneveld, A.D., Nijkamp, F.P. & van Oosterhout, A.J.M. (1997). Role for neurokinin-2 receptor in interleukin-5-induced airway hyperresponsiveness but not eosinophilia in guinea pigs. American Journal of Respiratory and Critical Care Medicine, 156, (pp. 367-374) (8 p.).
  1997 - Professional publications
Kraneveld, A.D. (1997). "Joint meeting" AAAAI/AAI/CIS. Pulmonair, 4, (pp. 5-7) (3 p.).
^ top
Gegenereerd op 2018-09-19 23:03:03
Additional functions and activities

Voorzittter van de Federatie Innovatief Geneesmiddelonderzoek Nederland (FIGON)

Penningmeester van Federation of European Pharmacological Societies

Gegenereerd op 2018-09-19 23:03:03
Full name
prof. dr. A.D. Kraneveld Contact details
David de Wiedgebouw

Universiteitsweg 99
Room 2.68
3584 CG  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 4509
Phone number (department) +31 30 253 7353
Mobile phone +31 6 20 248 767
Gegenereerd op 2018-09-19 23:03:03
Last updated 11.12.2015