Publicaties
2024
Wetenschappelijke publicaties
Ciarimboli, G.
, Masereeuw, R., & Oswald, S. (2024).
Editorial: Transporters: a hitchhiker's guide to physiology, toxicology, and pharmacology-TransportDays 2022.
Frontiers in Pharmacology,
15, 1365106.
https://doi.org/10.3389/fphar.2024.1365106Barnes, D. A., Firman, J. W., Belfield, S. J., Cronin, M. T. D., Vinken, M.
, Janssen, M. J., & Masereeuw, R. (2024).
Development of an adverse outcome pathway network for nephrotoxicity.
Archives of Toxicology.
https://doi.org/10.1007/s00204-023-03637-7 2023
Wetenschappelijke publicaties
Wang, Z., Xing, C., Laan, L. J. W. V. D., Verstegen, M. M. A.
, Spee, B., & Masereeuw, R. (2023).
Cholangiocyte Organoids to Model Chlorpromazine-Induced Bile Duct Injury. (pp. 1-26). Research Square.
https://doi.org/10.21203/rs.3.rs-3405852/v1 Garvi, E. S., Slobbe, G. V. D.
, Zaal, E. A., Baaij, J. H. F. D., Hoenderop, J.
, Masereeuw, R., Janssen, M. J., & Genderen, A. M. V. (2023).
A novel KCNJ16 kidney organoid model recapitulates the disease phenotype and shows restoration of lipid accumulation upon treatment with statins. (pp. 1-37). bioRxiv.
https://doi.org/10.1101/2023.12.22.572750 Faria, J., Calcat-i-Cervera, S., Skovronova, R., Broeksma, B. C.
, Berends, A. J., Zaal, E. A., Bussolati, B., O’Brien, T.
, Mihăilă, S. M., & Masereeuw, R. (2023).
Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury.
Stem cell research & therapy,
14(1), 1-19. Article 353.
https://doi.org/10.1186/s13287-023-03563-6 Slingerland, C. J., Lysenko, V., Chaudhuri, S.
, Wesseling, C. M. J., Barnes, D., Masereeuw, R., & Martin, N. I. (2023).
Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity.
RSC Medicinal Chemistry,
14(11), 2417-2425.
https://doi.org/10.1039/D3MD00456B Ahmed, S., Vries, J. C. D., Lu, J., Stuart, M. H. V.
, Mihăilă, S. M., Vernooij, R. W. M.
, Masereeuw, R., & Gerritsen, K. G. F. (2023).
Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review.
International Journal of Molecular Sciences,
24(17), Article 13197.
https://doi.org/10.3390/ijms241713197 Janssen, R., de Kleer, J. W. M., Heming, B., Bastiaan-Net, S.
, Garssen, J., Willemsen, L. E. M., & Masereeuw, R. (2023).
Food allergen sensitization on a chip: the gut-immune-skin axis.
Trends in Biotechnology,
42(1), 119-134. Advance online publication.
https://doi.org/10.1016/j.tibtech.2023.07.005 Faria, J., Ahmed, S., Stamatialis, D., Verhaar, M. C.
, Masereeuw, R., Gerritsen, K. G. F., & Mihăilă, S. M. (2023).
Bioengineered Kidney Tubules Efficiently Clear Uremic Toxins in Experimental Dialysis Conditions.
International Journal of Molecular Sciences,
24(15), Article 12435.
https://doi.org/10.3390/ijms241512435 Keuper-Navis, M., Walles, M., Poller, B.
, Myszczyszyn, A., van der Made, T. K., Donkers, J.
, Amirabadi, H. E., Wilmer, M. J., Aan, S.
, Spee, B., Masereeuw, R., & van de Steeg, E. (2023).
The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development.
Pharmacological Research,
195, Article 106853.
https://doi.org/10.1016/j.phrs.2023.106853 Ramada, D. L., Vries, J. D.
, Vollenbroek, J., Noor, N., Beek, O. T., Mihăilă, S. M., Wieringa, F.
, Masereeuw, R., Gerritsen, K., & Stamatialis, D. (2023).
Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges.
Nature Reviews Nephrology, (8).
https://doi.org/10.1038/s41581-023-00726-9Faucher, Q., van der Made, T. K., De Lange, E.
, & Masereeuw, R. (2023).
Blood-brain barrier perturbations by uremic toxins: key contributors in chronic kidney disease-induced neurological disorders? European Journal of Pharmaceutical Sciences,
187, 1-8. Article 106462.
https://doi.org/10.1016/j.ejps.2023.106462 Yang, Y., Mihajlovic, M., Janssen, M. J., & Masereeuw, R. (2023).
The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells.
Toxins,
15(4), 1-18. Article 242.
https://doi.org/10.3390/toxins15040242 Toropov, A. A.
, Barnes, D. A., Toropova, A. P., Roncaglioni, A.
, Irvine, A. R., Masereeuw, R., & Benfenati, E. (2023).
CORAL Models for Drug-Induced Nephrotoxicity.
Toxics,
11(4), Article 293.
https://doi.org/10.3390/toxics11040293Yengej, F. A. Y.
, Jansen, J., Ammerlaan, C. M. E., Dilmen, E.
, Casellas, C. P., Masereeuw, R., Hoenderop, J. G., Smeets, B., Rookmaaker, M. B., Verhaar, M. C.
, & Clevers, H. (2023).
Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids.
Proceedings of the National Academy of Sciences,
120(6), 1-11. Article e2216836120.
https://doi.org/10.1073/pnas.2216836120Zazuli, Z., Op 't Hoog, C. J. P.
, Vijverberg, S. J. H., Masereeuw, R., Rassekh, S. R., Medeiros, M., Rivas-Ruiz, R.
, Maitland-van der Zee, A. H., & Carleton, B. C. (2023).
Cisplatin-induced nephrotoxicity in childhood cancer: comparison between two countries.
Pediatric Nephrology,
38(2), 593-604.
https://doi.org/10.1007/s00467-022-05632-zhttps://dspace.library.uu.nl/bitstream/handle/1874/426080/s00467_022_05632_z.pdf?sequence=1 2022
Wetenschappelijke publicaties
Soares Lindoso, R., Yousef Yengej, F. A.
, Völlmy, F., Altelaar, M., Juncosa, E. M., Tsikari, T., Ammerlaan, C. M. E.
, van Balkom, B., Rookmaaker, M. B., Verhaar, M. C.
, & Masereeuw, R. (2022).
Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids.
Journal of Nanobiotechnology,
20(1), 1-15. Article 326.
https://doi.org/10.1186/s12951-022-01506-6 Jochems, P. G. M., Heming, B.
, Lapin, D., Moonen, N. E. L.
, Van den Ackerveken, G., & Masereeuw, R. (2022).
Bioengineered intestinal tubules as a tool to test intestinal biological efficacy of lettuce species.
npj Science of Food,
6(1), 1-8. Article 58.
https://doi.org/10.1038/s41538-022-00175-x Slingerland, C. J., Wesseling, C. M. J., Innocenti, P., Westphal, K. G. C., Masereeuw, R., & Martin, N. I. (2022).
Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids.
Journal of Medicinal Chemistry,
65(23), 15878–15892.
https://doi.org/10.1021/acs.jmedchem.2c01528 Wang, Z., Faria, J., van der Laan, L. J. W.
, Penning, L. C., Masereeuw, R., & Spee, B. (2022).
Human Cholangiocytes Form a Polarized and Functional Bile Duct on Hollow Fiber Membranes.
Frontiers in Bioengineering and Biotechnology,
10, 1-10. Article 868857.
https://doi.org/10.3389/fbioe.2022.868857 Madella, A. M., Bergenhenegouwen, J. V., Garssen, J., Masereeuw, R., & Overbeek, S. A. (2022).
Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation.
Toxins,
14(9), Article 645.
https://doi.org/10.3390/toxins14090645 Favero, C.
, Giordano, L., Mihaila, S. M., Masereeuw, R., Ortiz, A., & Sanchez-Niño, M. D. (2022).
Postbiotics and Kidney Disease.
Toxins,
14(9), 1-17. Article 623.
https://doi.org/10.3390/toxins14090623Genderen, A. M. V., G Valverde, M., Capendale, P. E.
, Kersten, V., Sendino Garví, E., Schuurmans, C. C. L., Ruelas, M., Soeiro, J. T., Tang, G.
, Janssen, M. J., Jansen, J., Mihăilă, S. M., Vermonden, T., Zhang, Y. S.
, & Masereeuw, R. (2022).
Co-axial Printing of Convoluted Proximal Tubule for Kidney Disease Modeling.
Biofabrication,
14(4), 1-16. Article 044102.
https://doi.org/10.1088/1758-5090/ac7895 Yang, Y., Mihajlovic, M., Valentijn, F., Nguyen, T. Q., Goldschmeding, R.
, & Masereeuw, R. (2022).
A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics.
Frontiers in Pharmacology,
13, 1-13. Article 791612.
https://doi.org/10.3389/fphar.2022.791612 Evenepoel, P., Meijers, B.
, Masereeuw, R., & Lowenstein, J. (2022).
Effects of an SGLT Inhibitor on the Production, Toxicity, and Elimination of Gut-Derived Uremic Toxins: A Call for Additional Evidence.
Toxins,
14(3), Article 210.
https://doi.org/10.3390/toxins14030210García Valverde, M., Ferreira Faria, J., Sendino Garví, E., Janssen, M. J., Masereeuw, R., & Mihaila, S. (2022).
Organs-on-chip technology: a tool to tackle genetic kidney diseases.
Pediatric Nephrology,
37(12), 2985-2996.
https://doi.org/10.1007/s00467-022-05508-2 Lindoso, R. S., Yengej, F. A. Y.
, Voellmy, F., Altelaar, M., Juncosa, E. M., Tsikari, T., Ammerlaan, C. M. E., Balkom, B. W. M. V., Verhaar, M. C.
, & Masereeuw, R. (2022).
Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids. (pp. 1-31). bioRxiv.
https://doi.org/10.1101/2022.02.08.479621https://dspace.library.uu.nl/bitstream/handle/1874/420003/2022.02.08.479621v1.full.pdf?sequence=1 Mihajlovic, M., Rikkers, M.
, Mihajlovic, M., Viola, M., Schuiringa, G.
, Ilochonwu, B. C., Masereeuw, R., Vonk, L.
, Malda, J., Ito, K.
, & Vermonden, T. (2022).
Viscoelastic Chondroitin Sulfate and Hyaluronic Acid Double-Network Hydrogels with Reversible Cross-Links.
Biomacromolecules,
23(3), 1350-1365.
https://doi.org/10.1021/acs.biomac.1c01583 Valverde, M. G., Mille, L. S., Figler, K. P., Cervantes, E., Li, V. Y., Bonventre, J. V.
, Masereeuw, R., & Zhang, Y. S. (2022).
Biomimetic models of the glomerulus.
Nature Reviews Nephrology,
18(4), 241-257.
https://doi.org/10.1038/s41581-021-00528-x Clerbaux, L.-A., Amigó, N., Amorim, M. J., Bal-Price, A., Batista Leite, S., Beronius, A., Bostroem, A.-C., Carusi, A., Coecke, S., Concha, R., Daskalopoulos, E. P., Debernardi, F., Edrosa, E., Edwards, S. W., Filipovska, J., Garcia-Reyero, N., Gavins, F. N. E., Halappanavar, S., Hargreaves, A. J., ... Wittwehr, C. (2022).
COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop.
Altex,
39(2), 322–335.
https://doi.org/10.14573/altex.2112161Garví, E. S., Masereeuw, R., & Janssen, M. J. (2022).
Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype.
Cells,
11(1), 1-18. Article 177.
https://doi.org/10.3390/cells11010177 Ahmed, S., Sparidans, R. W., Lu, J.
, Mihaila, S. M., Gerritsen, K. G. F., & Masereeuw, R. (2022).
A robust, accurate, sensitive LC-MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells.
Biomedical Chromatography,
36(5), 1-10. Article e5307.
https://doi.org/10.1002/bmc.5307 Amirabadi, H. E., Donkers, J. M., Wierenga, E., Ingenhut, B., Pieters, L., Stevens, L., Donkers, T., Westerhout, J.
, Masereeuw, R., Bobeldijk-Pastorova, I., Nooijen, I., & Steeg, E. V. D. (2022).
Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants.
Lab on a Chip,
2022(2), 326-342.
https://doi.org/10.1039/d1lc00669j Pou Casellas, C., Jansen, K., Rookmaaker, M. B.
, Clevers, H., Verhaar, M. C.
, & Masereeuw, R. (2022).
Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney: A Phylogenetic, Ontogenetic and Cell Dynamic Perspective.
Physiological Reviews,
102(2), 993-1024.
https://doi.org/10.1152/physrev.00009.2021 2021
Wetenschappelijke publicaties
Taranta, A., elmonem, M. A., Bellomo, F., Leo, E. D., Boenzi, S.
, Janssen, M. J., Jamalpoor, A., Cairoli, S., Pastore, A., Stefanis, C. D., Colucci, M., Rega, L. R., giovannoni, I., Francalanci, P., Heuvel, L. P. V. D., Dionisi-Vici, C., Goffredo, B. M.
, Masereeuw, R., Levtchenko, E., & Emma, F. (2021).
Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis.
Cells,
10(12), 1-16. Article 3294.
https://doi.org/10.3390/cells10123294Zazuli, Z., Jong, C. D. D., Xu, W.
, Vijverberg, S. J. H., Masereeuw, R., Patel, D., Mirshams, M., Khan, K., Cheng, D., Ordonez-Perez, B., Huang, S. H., Spreafico, A., Hansen, A. R., Goldstein, D. P., Almeida, J. R. D. D., Bratman, S. V., Hope, A., Knox, J. J., Wong, R. K. S., ... Liu, G. (2021).
Association between Genetic Variants and Cisplatin-Induced Nephrotoxicity: A Genome-Wide Approach and Validation Study.
Journal of Personalized Medicine,
11(11), 1-19. Article 1233.
https://doi.org/10.3390/jpm11111233https://dspace.library.uu.nl/bitstream/handle/1874/413633/jpm_11_01233_v3.pdf?sequence=1 Mihajlovic, M., Krebber, M. M.
, Yang, Y., Ahmed, S., Lozovanu, V., Andreeva, D., Verhaar, M. C.
, & Masereeuw, R. (2021).
Protein-Bound Uremic Toxins Induce Reactive Oxygen Species-Dependent and Inflammasome-Mediated IL-1β Production in Kidney Proximal Tubule Cells.
Biomedicines,
9(10), 1-24. Article 1326.
https://doi.org/10.3390/biomedicines9101326 King, J., Swapnasrita, S., Truckenmüller, R., Giselbrecht, S.
, Masereeuw, R., & Carlier, A. (2021).
Modeling Indoxyl Sulfate Transport in a Bioartificial Kidney: Two-Step Binding Kinetics or Lumped Parameters Model for Uremic Toxin Clearance? Computers in Biology and Medicine,
138, 1-9. Article 104912.
https://doi.org/10.1016/j.compbiomed.2021.104912King, J.
, Mihaila, S. M., Ahmed, S., Truckenmüller, R., Giselbrecht, S.
, Masereeuw, R., & Carlier, A. (2021).
The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study.
Toxins,
13(10), 1-19. Article 674.
https://doi.org/10.3390/toxins13100674Vermue, IJ. M., Begum, R., Castilho, M., Rookmaaker, M. B.
, Masereeuw, R., Bouten, C. V. C., Verhaar, M. C., & Cheng, C. (2021).
Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies.
ACS Biomaterials Science & Engineering,
7(10), 4679-4693.
https://doi.org/10.1021/acsbiomaterials.1c00408Groesen, E. V., Slingerland, C. J., Innocenti, P., Mihajlovic, M., Masereeuw, R., & Martin, N. I. (2021).
Vancomyxins: Vancomycin-Polymyxin Nonapeptide Conjugates That Retain Anti-Gram-Positive Activity with Enhanced Potency against Gram-Negative Strains.
ACS Infectious Diseases ,
7(9), 2746-2754.
https://doi.org/10.1021/acsinfecdis.1c00318 Irvine, A. R., van Berlo, D., Shekhani, R., & Masereeuw, R. (2021).
A systematic review of in vitro models of drug-induced kidney injury.
Current Opinion in Toxicology ,
27, 18-26.
https://doi.org/10.1016/j.cotox.2021.06.001 Faria, J., Gerritsen, K. G. F., Nguyen, T. Q.
, Mihaila, S. M., & Masereeuw, R. (2021).
Diabetic proximal tubulopathy: Can we mimic the disease for in vitro screening of SGLT inhibitors? European Journal of Pharmacology,
908, 1-11. Article 174378.
https://doi.org/10.1016/j.ejphar.2021.174378 Vinken, M., Benfenati, E., Busquet, F., Castell, J., Clevert, D.-A., de Kok, T., Dirven, H., Fritsche, E., Geris, L., Gozalbes, R., Hartung, T., Jennen, D., Jover, R., Kandarova, H.
, Kramer, N., Krul, C., Luechtefeld, T.
, Masereeuw, R., Roggen, E.
, ... Piersma, A. H. (2021).
Safer chemicals using less animals: kick-off of the European ONTOX project.
Toxicology,
458, 1-7. Article 152846.
https://doi.org/10.1016/j.tox.2021.152846https://dspace.library.uu.nl/bitstream/handle/1874/412525/1_s2.0_S0300483X21001694_main.pdf?sequence=1van Berlo, D., van de Steeg, E.
, Amirabadi, H. E., & Masereeuw, R. (2021).
The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing.
Current Opinion in Toxicology,
27, 8-17.
https://doi.org/10.1016/j.cotox.2021.05.001 Jamalpoor, A., van Gelder, C. A. G. H., Yousef Yengej, F. A.
, Zaal, E. A., Berlingerio, S. P., Veys, K. R.
, Pou Casellas, C., Voskuil, K., Essa, K., Ammerlaan, C. M. E., Rega, L. R., van der Welle, R. E. N., Lilien, M. R., Rookmaaker, M. B.
, Clevers, H., Klumperman, J., Levtchenko, E.
, Berkers, C. R., Verhaar, M. C.
, ... Janssen, M. J. (2021).
Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis.
EMBO Molecular Medicine,
13(7), 1-20. Article e13067.
https://doi.org/10.15252/emmm.202013067 Corrêa, R. R., Juncosa, E. M.
, Masereeuw, R., & Lindoso, R. S. (2021).
Extracellular Vesicles as a Therapeutic Tool for Kidney Disease: Current Advances and Perspectives.
International Journal of Molecular Sciences,
22(11), Article 5787.
https://doi.org/10.3390/ijms22115787Jamalpoor, A., Othman, A., Levtchenko, E. N.
, Masereeuw, R., & Janssen, M. J. (2021).
Molecular Mechanisms and Treatment Options of Nephropathic Cystinosis.
Trends in Molecular Medicine,
27(7), 673-686.
https://doi.org/10.1016/j.molmed.2021.04.004 Vriend, J., Vormann, M. K., Lanz, H. L., Joore, J., Trietsch, S. J., Russel, F. G. M., Jacobsen, B., Roth, A., Lu, S., Polli, J. W., Naidoo, A. A.
, Masereeuw, R., Wilmer, M. J., & Suter-Dick, L. (2021).
Nephroscreen: A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment.
Current Opinion in Toxicology,
25, 42-48.
https://doi.org/10.1016/j.cotox.2021.03.001Vlahou, A., Hallinan, D., Apweiler, R., Argiles, A., Beige, J., Benigni, A., Bischoff, R., Black, P. C., Boehm, F., Céraline, J., Chrousos, G. P., Delles, C., Evenepoel, P., Fridolin, I., Glorieux, G., van Gool, A. J., Heidegger, I., Ioannidis, J. P. A., Jankowski, J., ... Vanholder, R. (2021).
Data Sharing Under the General Data Protection Regulation: Time to Harmonize Law and Research Ethics? Hypertension (Dallas, Tex. : 1979),
77(4), 1029-1035.
https://doi.org/10.1161/HYPERTENSIONAHA.120.16340Vormann, M. K., Vriend, J., Lanz, H. L., Gijzen, L., van den Heuvel, A., Hutter, S., Joore, J., Trietsch, S. J., Stuut, C., Nieskens, T. T. G., Peters, J. G. P., Ramp, D., Caj, M., Russel, F. G. M., Jacobsen, B., Roth, A., Lu, S., Polli, J. W., Naidoo, A. A., ... Suter-Dick, L. (2021).
Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies.
Journal of Pharmaceutical Sciences,
110(4), 1601-1614.
https://doi.org/10.1016/j.xphs.2021.01.028van Genderen, A. M., Jansen, K., Kristen, M.
, van Duijn, J. H., Li, Y.
, Schuurmans, C. C. L., Malda, J., Vermonden, T., Jansen, J., Masereeuw, R., & Castilho, M. (2021).
Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance.
Frontiers in Bioengineering and Biotechnology,
8, 1-14. Article 617364.
https://doi.org/10.3389/fbioe.2020.617364 Jansen, K., Evangelopoulou, M.
, Pou Casellas, C., Abrishamcar, S., Jansen, J., Vermonden, T., & Masereeuw, R. (2021).
Spinach and Chive for Kidney Tubule Engineering: the Limitations of Decellularized Plant Scaffolds and Vasculature.
AAPS Journal,
23(1), 1-7. Article 11.
https://doi.org/10.1208/s12248-020-00550-0 Giordano, L., Mihaila, S. M., Eslami Amirabadi, H., & Masereeuw, R. (2021).
Microphysiological Systems to Recapitulate the Gut–Kidney Axis.
Trends in Biotechnology,
39(8), 811-823.
https://doi.org/10.1016/j.tibtech.2020.12.001 Wang, Z., Faria, J.
, Penning, L., Masereeuw, R., & Spee, B. (2021).
Tissue Engineered Bile Ducts for Disease Modeling and Therapy.
Tissue engineering. Part C, Methods,
27(2), 59-76.
https://doi.org/10.1089/ten.TEC.2020.0283 Rood, J. J. M., Jamalpoor, A., van Hoppe, S.
, van Haren, M. J., Wasmann, R. E.
, Janssen, M. J., Schinkel, A. H.
, Masereeuw, R., Beijnen, J. H., & Sparidans, R. W. (2021).
Extrahepatic metabolism of ibrutinib.
Investigational New Drugs,
39(1), 1-14.
https://doi.org/10.1007/s10637-020-00970-x 2020
Wetenschappelijke publicaties
Jamalpoor, A., van Gelder, C. A. G. H., Yousef Yengej, F. A.
, Zaal, E. A., Berlingerio, S. P., Veys, K. R.
, Pou Casellas, C., Voskuil, K., Essa, K., Ammerlaan, C., Rega, L. R., van der Welle, R., Lilien, M. R., Rookmaaker, M. B.
, Clevers, H. C., Klumperman, J., Levtchenko, E.
, Berkers, C. R., Verhaar, M. C.
, ... Janssen, M. J. (2020).
Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis. (pp. 1-53). bioRxiv.
https://doi.org/10.1101/2020.02.10.941799 Bajaj, P.
, Masereeuw, R., & McDuffie, J. E. (2020).
Predictive and translational models for renal drug safety evaluation. In
Identification and quantification of drugs, metabolites, drug metabolizing enzymes, and transporters: Concepts, Methods, and Translational Sciences (2 ed., pp. 507-534). Elsevier Science.
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A combined microphysiological-computational omics approach in dietary protein evaluation.
npj Science of Food,
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https://doi.org/10.1038/s41538-020-00082-z Zazuli, Z., Duin, N. J. C. B.
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The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition.
International Journal of Molecular Sciences,
21(18), Article 6627.
https://doi.org/10.3390/ijms21186627 Bauer, B., Renfro, J. L., Karnaky, K. J.
, Masereeuw, R., Fricker, G., Cannon, R. E., & Hartz, A. M. S. (2020).
David S. Miller: Scientist, Mentor, Friend-a tribute and thank you.
Fluids and Barriers of the CNS,
17(1), Article 56.
https://doi.org/10.1186/s12987-020-00220-5Jochems, P. G. M., Garssen, J., Rietveld, P. C. S., Govers, C., Tomassen, M. M. M., Wichers, H. J.
, van Bergenhenegouwen, J., & Masereeuw, R. (2020).
Novel Dietary Proteins Selectively Affect Intestinal Health In Vitro after Clostridium difficile-Secreted Toxin A Exposure.
Nutrients,
12(9), Article 2782.
https://doi.org/10.3390/nu12092782 Langerak, N.
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, Middel, I. R., Eslami Amirabadi, H., Malda, J., Masereeuw, R., & van Roij, R. (2020).
A Theoretical and Experimental Study to Optimize Cell Differentiation in a Novel Intestinal Chip.
Frontiers in Bioengineering and Biotechnology,
8, Article 763.
https://doi.org/10.3389/fbioe.2020.00763Zazuli, Z., Kos, R., Veltman, J. D., Uyterlinde, W., Longo, C., Baas, P.
, Masereeuw, R., Vijverberg, S. J. H., & Maitland-van der Zee, A. H. (2020).
Comparison of Myelotoxicity and Nephrotoxicity Between Daily Low-Dose Cisplatin With Concurrent Radiation and Cyclic High-Dose Cisplatin in Non-Small Cell Lung Cancer Patients.
Frontiers in Pharmacology,
11, Article 975.
https://doi.org/10.3389/fphar.2020.00975 Mihaila, S. M., Faria, J., Stefens, M. F. J., Stamatialis, D., Verhaar, M. C.
, Gerritsen, K. G. F., & Masereeuw, R. (2020).
Drugs commonly applied to kidney patients may compromise renal tubular uremic toxins excretion.
Toxins,
12(6), Article 391.
https://doi.org/10.3390/toxins12060391 De Leo, E., Elmonem, M. A., Berlingerio, S. P., Berquez, M., Festa, B. P., Raso, R., Bellomo, F., Starborg, T.
, Janssen, M. J., Abbaszadeh, Z., Cairoli, S., Goffredo, B. M.
, Masereeuw, R., Devuyst, O., Lowe, M., Levtchenko, E., Luciani, A., Emma, F., & Rega, L. R. (2020).
Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis.
Journal of the American Society of Nephrology : JASN,
31(7), 1522-1537.
https://doi.org/10.1681/ASN.2019090956Punt, A., Bouwmeester, H.
, Blaauboer, B. J., Coecke, S., Hakkert, B., Hendriks, D. F. G., Jennings, P.
, Kramer, N. I., Neuhoff, S.
, Masereeuw, R., Paini, A., Peijnenburg, A. A. C. M., Rooseboom, M., Shuler, M. L., Sorrell, I.
, Spee, B., Strikwold, M., Van der Meer, A. D., Van der Zande, M., ... Heringa, M. B. (2020).
New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.
Altex,
37(4), 607-622.
https://doi.org/10.14573/altex.2003242van Gelder, M. K., Middel, I. R., Vernooij, R. W. M., Bots, M. L., Verhaar, M. C.
, Masereeuw, R., Grooteman, M. P., Nubé, M. J., van den Dorpel, M. A., Blankestijn, P. J., Rookmaaker, M. B.
, & Gerritsen, K. G. F. (2020).
Protein-Bound Uremic Toxins in Hemodialysis Patients Relate to Residual Kidney Function, Are Not Influenced by Convective Transport, and Do Not Relate to Outcome.
Toxins,
12(4), Article 234.
https://doi.org/10.3390/toxins12040234Sun, Y., Goes Martini, A.
, Janssen, M. J., Garrelds, I. M.
, Masereeuw, R., Lu, X., & Danser, A. H. J. (2020).
Megalin: A Novel Endocytic Receptor for Prorenin and Renin.
Hypertension (Dallas, Tex. : 1979),
75(5), 1242-1250.
https://doi.org/10.1161/HYPERTENSIONAHA.120.14845Gong, J.
, Schuurmans, C. C. L., Genderen, A. M. V., Cao, X., Li, W., Cheng, F., He, J. J., López, A., Huerta, V., Manríquez, J., Li, R., Li, H., Delavaux, C., Sebastian, S., Capendale, P. E., Wang, H., Xie, J., Yu, M.
, Masereeuw, R., ... Zhang, Y. S. (2020).
Complexation-induced resolution enhancement of 3D-printed hydrogel constructs.
Nature Communications,
11(1), Article 1267.
https://doi.org/10.1038/s41467-020-14997-4Bovée, D. M., Visser, W. J., Middel, I., De Mik-van Egmond, A., Greupink, R.
, Masereeuw, R., Russel, F. G. M., Danser, A. H. J., Zietse, R., & Hoorn, E. J. (2020).
A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease.
Journal of the American Society of Nephrology : JASN,
31(3), 650-662.
https://doi.org/10.1681/ASN.2019090905Jansen, K., Pou Casellas, C., Groenink, L., Wever, K. E.
, & Masereeuw, R. (2020).
Humans are animals, but are animals human enough? A systematic review and meta-analysis on interspecies differences in renal drug clearance.
Drug Discovery Today,
25(4), 706-717.
https://doi.org/10.1016/j.drudis.2020.01.018 Vriend, J., Peters, J. G. P., Nieskens, T. T. G., Škovroňová, R., Blaimschein, N., Schmidts, M., Roepman, R., Schirris, T. J. J., Russel, F. G. M.
, Masereeuw, R., & Wilmer, M. J. (2020).
Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia.
Biochimica et Biophysica Acta - General Subjects,
1864(1), Article 129433.
https://doi.org/10.1016/j.bbagen.2019.129433Sánchez-Romero, N., Martínez-Gimeno, L.
, Caetano-Pinto, P., Saez, B., Sánchez-Zalabardo, J. M.
, Masereeuw, R., & Giménez, I. (2020).
A simple method for the isolation and detailed characterization of primary human proximal tubule cells for renal replacement therapy.
International Journal of Artificial Organs,
43(1), 45-57.
https://doi.org/10.1177/0391398819866458 2019
Wetenschappelijke publicaties
Louzao-Martinez, L., van Dijk, C. G. M., Juan Xu, Y., Korn, A., Bekker, N., Brouwhuis, R., Nicese, M. N., Demmers, J. A. A., Goumans, M.-J. T. H.
, Masereeuw, R., Duncker, D. J., Verhaar, M. C., & Cheng, C. (2019).
A proteome comparison between human fetal and mature renal extracellular matrix identifies EMILIN1 as a regulator of renal epithelial cell adhesion.
Matrix Biology,
4, Article 100011.
https://doi.org/10.1016/j.mbplus.2019.100011Faria, J., Ahmed, S., Gerritsen, K. G. F., Mihaila, S. M., & Masereeuw, R. (2019).
Kidney-based in vitro models for drug-induced toxicity testing.
Archives of Toxicology,
93, 3397–3418.
https://doi.org/10.1007/s00204-019-02598-0 Abyar, S., Khandar, A. A., Salehi, R., Abolfazl Hosseini-Yazdi, S., Alizadeh, E., Mahkam, M.
, Jamalpoor, A., White, J. M., Shojaei, M.
, Aizpurua-Olaizola, O., Masereeuw, R., & Janssen, M. J. (2019).
In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes.
Scientific Reports,
9, Article 14686.
https://doi.org/10.1038/s41598-019-51109-9 Janssen, M. J., Nieskens, T. T. G., Steevels, T. A. M.
, Caetano-Pinto, P., den Braanker, D., Mulder, M., Ponstein, Y., Jones, S.
, Masereeuw, R., den Besten, C., & Wilmer, M. J. (2019).
Therapy with 2'-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption.
Molecular Therapy - Nucleic Acids,
18, 298-307.
https://doi.org/10.1016/j.omtn.2019.08.025 Mihajlovic, M., Hariri, S.
, Westphal, K. C. G., Janssen, M. J., Oost, M. J.
, Bongiovanni, L., Van Den Heuvel, L. P.
, De Bruin, A., Hilbrands, L. B.
, & Masereeuw, R. (2019).
Safety evaluation of conditionally immortalized cells for renal replacement therapy.
Oncotarget,
10(51), 5332-5348.
https://doi.org/10.18632/oncotarget.27152 Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J.
, Sastre Torano, J., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J.
, van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B.
, & Masereeuw, R. (2019).
Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion.
Proceedings of the National Academy of Sciences of the United States of America,
116(32), 16105-16110.
https://doi.org/10.1073/pnas.1821809116 Deltombe, O., Glorieux, G., Marzouki, S.
, Masereeuw, R., Schneditz, D., & Eloot, S. (2019).
Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes.
Toxins,
11(7), Article 385.
https://doi.org/10.3390/toxins11070385Zazuli, Z., Otten, L. S., Drögemöller, B. I., Medeiros, M., Monzon, J. G., Wright, G. E. B., Kollmannsberger, C. K., Bedard, P. L., Chen, Z., Gelmon, K. A., McGoldrick, N., Kitchlu, A.
, Vijverberg, S. J. H., Masereeuw, R., Ross, C. J. D., Liu, G., Carleton, B. C.
, & Maitland-van der Zee, A. H. (2019).
Outcome Definition Influences the Relationship Between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients.
Genes,
10(5), Article 364.
https://doi.org/10.3390/genes10050364 Jochems, P. G. M., van Bergenhenegouwen, J., van Genderen, A. M., Eis, S. T., Wilod Versprille, L. J. F., Wichers, H. J.
, Jeurink, P. V., Garssen, J., & Masereeuw, R. (2019).
Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients.
Toxicology in Vitro,
60, 1-11.
https://doi.org/10.1016/j.tiv.2019.04.019 on behalf of the European Uremic Toxin Work Group-EUTox (2019).
Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients.
Scientific Reports,
9(1), Article 4477.
https://doi.org/10.1038/s41598-019-41101-8Schutgens, F., Rookmaaker, M. B., Margaritis, T., Rios, A., Ammerlaan, C.
, Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yengej, F. Y., Derakhshan, S., de Winter-de Groot, K. M., Artegiani, B., van Boxtel, R.
, Cuppen, E., Hendrickx, A. P. A., van den Heuvel-Eibrink, M. M., Heitzer, E.
, ... Clevers, H. (2019).
Tubuloids derived from human adult kidney and urine for personalized disease modeling.
Nature Biotechnology,
37(3), 303-313.
https://doi.org/10.1038/s41587-019-0048-8Mihajlovic, M., Wever, K. E., van der Made, T. K., de Vries, R. B. M., Hilbrands, L. B.
, & Masereeuw, R. (2019).
Are cell-based therapies for kidney disease safe? A systematic review of preclinical evidence.
Pharmacology and Therapeutics,
197, 191-211.
https://doi.org/10.1016/j.pharmthera.2019.01.004 Vriend, J., Hoogstraten, C. A., Venrooij, K. R., Berge, B. T. V. D., Govers, L. P., Rooij, A. V., Huigen, M. C. D. G., Schirris, T. J. J., Russel, F. G. M.
, Masereeuw, R., & Wilmer, M. J. (2019).
Organic anion transporter 1 and 3 influence cellular energy metabolism in renal proximal tubule cells.
Biological Chemistry,
400(10), 1347–1358.
https://doi.org/10.1515/hsz-2018-0446Jansen, K., Castilho, M., Aarts, S., Kaminski, M. M., Lienkamp, S. S., Pichler, R.
, Malda, J., Vermonden, T., Jansen, J., & Masereeuw, R. (2019).
Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds.
Macromolecular Bioscience,
19(2), Article e1800412.
https://doi.org/10.1002/mabi.201800412 van Gaal, R. C.
, Fedecostante, M., Fransen, P.-P. K. H.
, Masereeuw, R., & Dankers, P. Y. W. (2019).
Renal Epithelial Monolayer Formation on Monomeric and Polymeric Catechol Functionalized Supramolecular Biomaterials.
Macromolecular Bioscience,
19(2), Article e1800300.
https://doi.org/10.1002/mabi.201800300Groth, C., van Groningen, L. F. J., Matos, T. R., Bremmers, M. E., Preijers, F. W. M. B., Dolstra, H., Reicherts, C., Schaap, N. P. M., van Hooren, E. H. G., IntHout, J., Netea, M. G.
, Masereeuw, R., Levine, J. E., Morales, G., Ferrara, J. L., Blijlevens, N. M. A., van Oosterhout, Y. V. J. M., Stelljes, M., & van der Velden, W. J. F. M. (2019).
Phase I/II trial of a combination of anti-CD3/CD7 immunotoxins for steroid-refractory acute graft-versus-host disease.
Biology of Blood and Marrow Transplantation,
25(4), 712-719.
https://doi.org/10.1016/j.bbmt.2018.10.020Mihajlovic, M., Mihajlovic, M., Dankers, P. Y. W.
, Masereeuw, R., & Sijbesma, R. P. (2019).
Carbon Nanotube Reinforced Supramolecular Hydrogels for Bioapplications.
Macromolecular Bioscience,
19(1), Article e1800173.
https://doi.org/10.1002/mabi.201800173 Vakpublicaties
van der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-Hodjegan, A.
, Sastre Toraño, J., Middel, I.
, Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J.
, Masereeuw, R., & Galetin, A. (2019).
Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease.
Molecular Pharmaceutics,
16, 4551-4562.
https://doi.org/10.1021/acs.molpharmaceut.9b00681 2018
Wetenschappelijke publicaties
Zazuli, Z., Vijverberg, S., Slob, E., Liu, G., Carleton, B., Veltman, J., Baas, P.
, Masereeuw, R., & Maitland-van der Zee, A.-H. (2018).
Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review.
Frontiers in Pharmacology,
9, Article 1111.
https://doi.org/10.3389/fphar.2018.01111 Legallais, C., Kim, D., Mihaila, S. M.
, Mihajlovic, M., Figliuzzi, M., Bonandrini, B., Salerno, S., Yousef Yengej, F. A., Rookmaaker, M. B.
, Sanchez Romero, N., Sainz-Arnal, P., Pereira, U., Pasqua, M.
, Gerritsen, K. G. F., Verhaar, M. C., Remuzzi, A., Baptista, P. M., De Bartolo, L.
, Masereeuw, R., & Stamatialis, D. (2018).
Bioengineering Organs for Blood Detoxification.
Advanced healthcare materials,
7(21), Article e1800430.
https://doi.org/10.1002/adhm.201800430Vormann, M. K., Gijzen, L., Hutter, S., Boot, L., Nicolas, A., van den Heuvel, A., Vriend, J., Ng, C. P., Nieskens, T. T. G., van Duinen, V., de Wagenaar, B.
, Masereeuw, R., Suter-Dick, L., Trietsch, S. J., Wilmer, M., Joore, J., Vulto, P., & Lanz, H. L. (2018).
Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules.
The AAPS journal,
20(5), Article 90.
https://doi.org/10.1208/s12248-018-0248-zvan Genderen, A. M., Jansen, J., Cheng, C.
, Vermonden, T., & Masereeuw, R. (2018).
Renal Tubular- and Vascular Basement Membranes and their Mimicry in Engineering Vascularized Kidney Tubules.
Advanced healthcare materials,
7(19), Article e1800529.
https://doi.org/10.1002/adhm.201800529 Suter-Dick, L., Mauch, L., Ramp, D., Caj, M., Vormann, M. K., Hutter, S., Lanz, H. L., Vriend, J.
, Masereeuw, R., & Wilmer, M. J. (2018).
Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study.
The AAPS journal,
20(5), Article 86.
https://doi.org/10.1208/s12248-018-0245-2Vriend, J., Nieskens, T. T. G., Vormann, M. K., van den Berge, B. T., van den Heuvel, A., Russel, F. G. M., Suter-Dick, L., Lanz, H. L., Vulto, P.
, Masereeuw, R., & Wilmer, M. J. (2018).
Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip.
The AAPS journal,
20(5), Article 87.
https://doi.org/10.1208/s12248-018-0247-0Schuurmans, C. C. L., Abbadessa, A., Bengtson, M. A., Pletikapic, G.
, Eral, H. B., Koenderink, G.
, Masereeuw, R., Hennink, W. E., & Vermonden, T. (2018).
Complex coacervation-based loading and tunable release of a cationic protein from monodisperse glycosaminoglycan microgels.
Soft Matter,
14(30), 6327-6341.
https://doi.org/10.1039/c8sm00686e Fedecostante, M., Westphal, K., Buono, M.
, Sanchez Romero, N., Wilmer, M. J., Kerkering, J., Baptista, P. M., Hoenderop, J. G.
, & Masereeuw, R. (2018).
Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening.
Drug Metabolism and Disposition,
46(9), 1338-1350.
https://doi.org/10.1124/dmd.118.080721 van Raaij, S. E. G.
, Masereeuw, R., Swinkels, D. W., & van Swelm, R. P. L. (2018).
Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells.
Toxicology Letters,
295, 179-186.
https://doi.org/10.1016/j.toxlet.2018.06.1218Chen, C.
, Jochems, P., Salz, L.
, Schneeberger, K., Penning, L. C., van de Graaf, S. F. J., Beuers, U.
, Clevers, H., Geijsen, N., Masereeuw, R., & Spee, B. (2018).
Bioengineered bile ducts recapitulate key cholangiocyte functions.
Biofabrication,
10(3), Article 034103.
https://doi.org/10.1088/1758-5090/aac8fdvan Gelder, M. K.
, Mihaila, S. M., Jansen, J., Wester, M., Verhaar, M. C., Joles, J. A., Stamatialis, D.
, Masereeuw, R., & Gerritsen, K. G. F. (2018).
From portable dialysis to a bioengineered kidney.
Expert Review of Medical Devices,
15(5), 323-336.
https://doi.org/10.1080/17434440.2018.1462697Chevtchik, N. V.
, Mihajlovic, M., Fedecostante, M., Bolhuis-Versteeg, L.
, Sastre Toraño, J., Masereeuw, R., & Stamatialis, D. (2018).
A bioartificial kidney device with polarized secretion of immune modulators.
Journal of Tissue Engineering and Regenerative Medicine,
12(7), 1670–1678.
https://doi.org/10.1002/term.2694Soo, J. Y.-C.
, Jansen, J., Masereeuw, R., & Little, M. H. (2018).
Advances in predictive in vitro models of drug-induced nephrotoxicity.
Nature Reviews Nephrology,
14(6), 378-393.
https://doi.org/10.1038/s41581-018-0003-9Jochems, P. G. M., Garssen, J., van Keulen, A. M.
, Masereeuw, R., & Jeurink, P. V. (2018).
Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption.
Nutrients,
10(3), Article 322.
https://doi.org/10.3390/nu10030322 Nieskens, T. TG., Peters, J. GP., Dabaghie, D., Korte, D.
, Jansen, K., van Asbeck, A. H., Tavraz, N. N., Friedrich, T., Russel, F. G.
, Masereeuw, R., & Wilmer, M. J. (2018).
Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity.
Drug Metabolism and Disposition,
46(5), 592-599.
https://doi.org/10.1124/dmd.117.079384Jamalpoor, A., Sparidans, R. W., Casellas, C. P.
, Rood, J. J. M., Joshi, M.
, Masereeuw, R., & Janssen, M. J. (2018).
Quantification of cystine in human renal proximal tubule cells using liquid chromatography-tandem mass spectrometry.
Biomedical Chromatography,
32(8), 1-7. Article e4238.
https://doi.org/10.1002/bmc.4238 Santana Machado, T., Poitevin, S., Paul, P., McKay, N., Jourde-Chiche, N., Legris, T., Mouly-Bandini, A., Dignat-George, F., Brunet, P.
, Masereeuw, R., Burtey, S., & Cerini, C. (2018).
Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling.
Journal of the American Society of Nephrology : JASN,
29(3), 906-918.
https://doi.org/10.1681/ASN.2017030361Hulshof, F., Schophuizen, C.
, Mihajlovic, M., van Blitterswijk, C.
, Masereeuw, R., de Boer, J., & Stamatialis, D. (2018).
New insights into the effects of biomaterial chemistry and topography on the morphology of kidney epithelial cells.
Journal of Tissue Engineering and Regenerative Medicine,
12(2), e817-e827.
https://doi.org/10.1002/term.23872017
Wetenschappelijke publicaties
Chevtchik, N. V., Caetano Pinto, P., Masereeuw, R., & Stamatialis, D. (2017). Membranes for bioartificial kidney devices. In D. Stamatialis (Ed.), Biomedical Membranes And (Bio)artificial Organs (pp. 105-147). (World scientific series in membrane science and technology; Vol. 2). World Scientific Publishing Co. Pte Ltd.
Mihajlovic, M., Fedecostante, M., Oost, M. J., Steenhuis, S. K. P., Lentjes, E. G. W. M., Maitimu-Smeele, I.
, Janssen, M. J., Hilbrands, L. B.
, & Masereeuw, R. (2017).
Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions.
International Journal of Molecular Sciences,
18(12), Article 2531.
https://doi.org/10.3390/ijms18122531 Masereeuw, R., Vriend, J., & Wilmer, M. J. (2017).
Kidney-on-a-Chip: Technologies for Studying Pharmacological and Therapeutic Approaches to Kidney Repair. In
Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era (pp. 1119-1133). Elsevier.
https://doi.org/10.1016/B978-0-12-801734-0.00082-5 Reda, A., Raaijmakers, A., van Dorst, S., Pauwels, C. G. G. M., Allegaert, K., Elmonem, M. A.
, Masereeuw, R., van den Heuvel, L. W. P. J., Levtchenko, E., & Arcolino, F. O. (2017).
A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition.
Current Pharmaceutical Design,
23(38), 5911 - 5918.
https://doi.org/10.2174/1381612823666171009143146Jansen, K., Schuurmans, C. C. L., Jansen, J., Masereeuw, R., & Vermonden, T. (2017).
Hydrogel-based cell therapies for kidney regeneration: current trends in biofabrication and in vivo repair.
Current Pharmaceutical Design,
23(26), 3845 - 3857.
https://doi.org/10.2174/1381612823666170710155726 Mihajlovic, M., van den Heuvel, L. W. P. J., Hoenderop, J. G. J.
, Jansen, J., Wilmer, M. J., Westheim, A. J. F., Allebes, W. A., Stamatialis, D., Hilbrands, L. B.
, & Masereeuw, R. (2017).
Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application.
Scientific Reports,
7(1), Article 7103.
https://doi.org/10.1038/s41598-017-07582-1 Schirris, T. J. J.
, Jansen, J., Mihajlovic, M., van den Heuvel, L. P.
, Masereeuw, R., & Russel, F. G. M. (2017).
Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model.
Scientific Reports,
7, Article 10623.
https://doi.org/10.1038/s41598-017-10483-yJansen, J., Jankowski, J., Gajjala, P. R., Wetzels, J. F. M.
, & Masereeuw, R. (2017).
Disposition and clinical implications of protein-bound uremic toxins.
Clinical Science,
131(14), 1631-1647.
https://doi.org/10.1042/CS20160191 Caetano-Pinto, P., Jamalpoor, A., Ham, J., Goumenou, A., Mommersteeg, M., Pijnenburg, D.
, Ruijtenbeek, R., Sánchez-Romero, N., van Zelst, B., Heil, S.
, Jansen, J., Wilmer, M. J., van Herpen, C. M. L.
, & Masereeuw, R. (2017).
Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters.
Molecular Pharmaceutics,
14(6), 2147-2157.
https://doi.org/10.1021/acs.molpharmaceut.7b00308 Fedecostante, M., Onciu, O. G.
, Westphal, K. G. C., & Masereeuw, R. (2017).
Towards a bioengineered kidney: recellularization strategies for decellularized native kidney scaffolds.
International Journal of Artificial Organs,
40(4), 150-158.
https://doi.org/10.5301/ijao.5000564 Maicas, N., van der Vlag, J., Bublitz, J., Florquin, S., Bakker-van Bebber, M., Dinarello, C. A., Verweij, V.
, Masereeuw, R., Joosten, L. A., & Hilbrands, L. B. (2017).
Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury.
PLoS One,
12(2), Article e0168981.
https://doi.org/10.1371/journal.pone.0168981Caetano-Pinto, P., Jansen, J., Assaraf, Y. G.
, & Masereeuw, R. (2017).
The importance of breast cancer resistance protein to the kidneys excretory function and chemotherapeutic resistance.
Drug Resistance Updates,
30, 15-27.
https://doi.org/10.1016/j.drup.2017.01.002 Peters, E., Schirris, T., van Asbeck, A. H., Gerretsen, J., Eymael, J., Ashikov, A., Adjobo-Hermans, M. J. W., Russel, F., Pickkers, P.
, & Masereeuw, R. (2017).
Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells.
European Journal of Pharmacology,
796, 149-157.
https://doi.org/10.1016/j.ejphar.2016.12.0342016
Wetenschappelijke publicaties
van den Brand, J. A. J. G., Mutsaers, H. A. M., van Zuilen, A. D., Blankestijn, P. J., van den Broek, P. H., Russel, F. G. M.
, Masereeuw, R., & Wetzels, J. F. M. (2016).
Uremic Solutes in Chronic Kidney Disease and Their Role in Progression.
PLoS One,
11(12), Article e0168117.
https://doi.org/10.1371/journal.pone.0168117Peters, E., Ergin, B., Kandil, A., Gurel-Gurevin, E., van Elsas, A.
, Masereeuw, R., Pickkers, P., & Ince, C. (2016).
Effects of a human recombinant alkaline phosphatase on renal hemodynamics, oxygenation and inflammation in two models of acute kidney injury.
Toxicology and Applied Pharmacology,
313, 88-96.
https://doi.org/10.1016/j.taap.2016.10.015van Breda, G. F., Bongartz, L. G., Zhuang, W., van Swelm, R. P. L., Pertijs, J., Braam, B., Cramer, M.-J., Swinkels, D. W., Doevendans, P. A., Verhaar, M. C.
, Masereeuw, R., Joles, J. A., & Gaillard, C. A. J. M. (2016).
Cardiac Hepcidin Expression Associates with Injury Independent of Iron.
American Journal of Nephrology,
44(5), 368-378.
https://doi.org/10.1159/000449419Huang, J., Weinfurter, S.
, Pinto, P. C., Pretze, M., Kränzlin, B., Pill, J., Federica, R., Perciaccante, R., Ciana, L. D.
, Masereeuw, R., & Gretz, N. (2016).
Fluorescently labeled cyclodextrin derivatives as exogenous markers for real-time transcutaneous measurement of renal function.
Bioconjugate Chemistry,
27(10), 2513-2526.
https://doi.org/10.1021/acs.bioconjchem.6b00452Sánchez-Romero, N., Schophuizen, C. M. S., Giménez, I.
, & Masereeuw, R. (2016).
In vitro systems to study nephropharmacology: 2D versus 3D models.
European Journal of Pharmacology, 1-10.
https://doi.org/10.1016/j.ejphar.2016.07.010 Chevtchik, N. V.
, Fedecostante, M., Jansen, J., Mihajlovic, M., Wilmer, M., Rüth, M.
, Masereeuw, R., & Stamatialis, D. (2016).
Upscaling of a living membrane for bioartificial kidney device.
European Journal of Pharmacology,
790, 28-35.
https://doi.org/10.1016/j.ejphar.2016.07.009Jansen, J., Fedecostante, M., Wilmer, M. J., Peters, J. G., Kreuser, U. M., van den Broek, P. H., Mensink, R. A., Boltje, T. J., Stamatialis, D., Wetzels, J. F., van den Heuvel, L. P., Hoenderop, J. G.
, & Masereeuw, R. (2016).
Bioengineered kidney tubules efficiently excrete uremic toxins.
Scientific Reports,
6, Article 6:26715.
https://doi.org/10.1038/srep26715 Peters, E., Heuberger, J. A. A. C., Tiessen, R., van Elsas, A.
, Masereeuw, R., Arend, J., Stevens, J., & Pickkers, P. (2016).
Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers.
Clinical Pharmacokinetics,
55, 1227–1237.
https://doi.org/10.1007/s40262-016-0399-yCaetano-Pinto, P., Janssen, M. J., Gijzen, L., Verscheijden, L., Wilmer, M. J. G.
, & Masereeuw, R. (2016).
Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line.
Molecular Pharmaceutics,
13, 933-944.
https://doi.org/10.1021/acs.molpharmaceut.5b00821 van Swelm, R. P. L., Wetzels, J. F. M., Verweij, V. G. M., Laarakkers, C. M. M., Pertijs, J. C. L. M., van der Wijst, J., Thévenod, F.
, Masereeuw, R., & Swinkels, D. W. (2016).
Renal Handling of Circulating and Renal-Synthesized Hepcidin and Its Protective Effects against Hemoglobin-Mediated Kidney Injury.
Journal of the American Society of Nephrology,
27(9), 2720-2732.
https://doi.org/10.1681/ASN.2015040461Nieskens, T. T. G., Peters, J. G. P., Schreurs, M. J., Smits, N., Woestenenk, R., Jansen, K., van der Made, T. K., Röring, M., Hilgendorf, C., Wilmer, M. J.
, & Masereeuw, R. (2016).
A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.
The AAPS journal,
18(2), 465-475.
https://doi.org/10.1208/s12248-016-9871-8Gozalpour, E., Wilmer, M., Bilos, A.
, Masereeuw, R., Russel, F. G. M., & Koenderink, J. B. (2016).
Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays.
Toxicology in Vitro,
32, 138-145.
https://doi.org/10.1016/j.tiv.2015.12.009Wilmer, M. J., Ng, C. P., Lanz, H. L., Vulto, P., Suter-Dick, L.
, & Masereeuw, R. (2016).
Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening.
Trends in Biotechnology,
34(2), 156-170.
https://doi.org/10.1016/j.tibtech.2015.11.0012015
Wetenschappelijke publicaties
Jansen, J., De Napoli, I. E.
, Fedecostante, M., Schophuizen, C. M. S., Chevtchik, N. V., Wilmer, M. J., van Asbeck, A. H., Croes, H. J., Pertijs, J. C., Wetzels, J. F. M., Hilbrands, L. B.
, van den Heuvel, L. P., Hoenderop, J. G., Stamatialis, D.
, & Masereeuw, R. (2015).
Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations.
Scientific Reports,
5, Article 16702.
https://doi.org/10.1038/srep16702 Poesen, R., Mutsaers, H. A. M., Windey, K., van den Broek, P. H., Verweij, V., Augustijns, P., Kuypers, D., Jansen, J., Evenepoel, P., Verbeke, K., Meijers, B.
, & Masereeuw, R. (2015).
The Influence of Dietary Protein Intake on Mammalian Tryptophan and Phenolic Metabolites.
PLoS One,
10(10), e0140820.
https://doi.org/10.1371/journal.pone.0140820Peters, E., Stevens, J., Arend, J., Guan, Z., Raaben, W., Laverman, P., Elsas, A. V.
, Masereeuw, R., & Pickkers, P. (2015).
Biodistribution and translational pharmacokinetic modeling of a human recombinant alkaline phosphatase.
International Journal of Pharmaceutics,
495, 122.
https://doi.org/10.1016/j.ijpharm.2015.08.090Mutsaers, H. A. M.
, Caetano Pinto, P., Seegers, A. E. M., Dankers, A. C. A., van den Broek, P. H. H., Wetzels, J. F. M., van den Brand, J. A. J. G., van den Heuvel, L. P., Hoenderop, J. G., Wilmer, M. J. G.
, & Masereeuw, R. (2015).
Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology.
Toxicology in Vitro,
29(7), 1868-1877.
https://doi.org/10.1016/j.tiv.2015.07.020Peters, E., Geraci, S., Heemskerk, S., Wilmer, M. J., Bilos, A., Kraenzlin, B., Gretz, N., Pickkers, P.
, & Masereeuw, R. (2015).
Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate.
British Journal of Pharmacology,
172(20), 4932-4945.
https://doi.org/10.1111/bph.13261Schophuizen, C. M. S., De Napoli, I. E., Jansen, J., Teixeira, S., Wilmer, M. J., Hoenderop, J. G. J., Van den Heuvel, L. P. W.
, Masereeuw, R., & Stamatialis, D. (2015).
Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane.
Acta Biomaterialia,
14, 22-32.
https://doi.org/10.1016/j.actbio.2014.12.002Knops, N., van den Heuvel, L. P.
, Masereeuw, R., Bongaers, I., de Loor, H., Levtchenko, E., & Kuypers, D. (2015).
The functional implications of common genetic variation in CYP3A5 and ABCB1 in human proximal tubule cells.
Molecular Pharmaceutics,
12(3), 758-68.
https://doi.org/10.1021/mp500590sSchophuizen, C. M. S., Hoenderop, J. G. J.
, Masereeuw, R., & Heuvel, L. P. V. D. (2015).
Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently.
Cells,
4(3), 234-52.
https://doi.org/10.3390/cells40302342014
Wetenschappelijke publicaties
van Swelm, R. P. L., Hadi, M., Laarakkers, C. M. M.
, Masereeuw, R., Groothuis, G. M. M., & Russel, F. G. M. (2014).
Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.
Journal of applied toxicology,
34(9), 993-1001.
https://doi.org/10.1002/jat.2917Peters, E., Heemskerk, S.
, Masereeuw, R., & Pickkers, P. (2014).
Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients.
American Journal of Kidney Diseases,
63(6), 1038-48.
https://doi.org/10.1053/j.ajkd.2013.11.027El-Sheikh, A. A. K., Koenderink, J. B., Wouterse, A. C., van den Broek, P. H. H., Verweij, V. G. M.
, Masereeuw, R., & Russel, F. G. M. (2014).
Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus.
Translational Research,
164(1), 46-56.
https://doi.org/10.1016/j.trsl.2014.01.006Jansen, J., Schophuizen, C. M. S., Wilmer, M. J., Lahham, S. H. M., Mutsaers, H. A. M., Wetzels, J. F. M., Bank, R. A., van den Heuvel, L. P., Hoenderop, J. G.
, & Masereeuw, R. (2014).
A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue.
Experimental Cell Research,
323(1), 87-99.
https://doi.org/10.1016/j.yexcr.2014.02.011Mutsaers, H. A. M., Levtchenko, E. N., Martinerie, L., Pertijs, J. C. L. M., Allegaert, K., Devriendt, K.
, Masereeuw, R., Monnens, L. A. H., & Lombès, M. (2014).
Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions.
Journal of Clinical Endocrinology and Metabolism,
99(7), E1361-7.
https://doi.org/10.1210/jc.2014-1123Masereeuw, R., Mutsaers, H. A. M., Toyohara, T., Abe, T., Jhawar, S., Sweet, D. H., & Lowenstein, J. (2014).
The kidney and uremic toxin removal: glomerulus or tubule? Seminars in Nephrology,
34(2), 191-208.
https://doi.org/10.1016/j.semnephrol.2014.02.010 Jansen, J., Fedecostante, M., Wilmer, M. J., van den Heuvel, L. P., Hoenderop, J. G.
, & Masereeuw, R. (2014).
Biotechnological challenges of bioartificial kidney engineering.
Biotechnology Advances,
32(7), 1317-27.
https://doi.org/10.1016/j.biotechadv.2014.08.001van Swelm, R. P. L., Kramers, C.
, Masereeuw, R., & Russel, F. G. M. (2014).
Application of urine proteomics for biomarker discovery in drug-induced liver injury.
Critical Reviews in Toxicology,
44(10), 823-41.
https://doi.org/10.3109/10408444.2014.931341Gozalpour, E., Greupink, R., Bilos, A., Verweij, V., van den Heuvel, J. J. M. W.
, Masereeuw, R., Russel, F. G. M., & Koenderink, J. B. (2014).
Convallatoxin: a new P-glycoprotein substrate.
European Journal of Pharmacology,
744, 18-27.
https://doi.org/10.1016/j.ejphar.2014.09.031Peters, E.
, Masereeuw, R., & Pickkers, P. (2014).
The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury.
Nephron. Clinical practice,
127(1-4), 144-8.
https://doi.org/10.1159/000363256Vakpublicaties
Mutsaers, H. A. M.
, Masereeuw, R., & Olinga, P. (2014).
Altered tryptophan metabolism and CKD-associated fatigue.
Kidney International,
86(5), 1061-2.
https://doi.org/10.1038/ki.2014.2372013
Wetenschappelijke publicaties
Masereeuw, R., Draisma, A., Heemskerk, S., Bouw, M. P. W. J. M., Laarakkers, C., van der Hoeven, J. G., & Pickkers, P. (2013).
Potential new markers of inflammation-induced renal injury subside when endotoxin tolerance develops in humans.
Journal of Proteomics and Bioinformatics,
6(3), 58-64.
https://doi.org/10.4172/jpb.1000262 Moghadasali, R., Mutsaers, H. A. M., Azarnia, M., Aghdami, N., Baharvand, H., Torensma, R., Wilmer, M. J. G.
, & Masereeuw, R. (2013).
Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity.
Experimental and Toxicologic Pathology,
65(5), 595-600.
https://doi.org/10.1016/j.etp.2012.06.002Mutsaers, H. A. M., Wilmer, M. J. G., Reijnders, D., Jansen, J., van den Broek, P. H. H., Forkink, M., Schepers, E., Glorieux, G., Vanholder, R., van den Heuvel, L. P., Hoenderop, J. G.
, & Masereeuw, R. (2013).
Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration.
Biochimica et Biophysica Acta,
1832(1), 142-50.
https://doi.org/10.1016/j.bbadis.2012.09.006Wagener, F. A. D. T. G., Dankers, A. C. A., van Summeren, F., Scharstuhl, A., van den Heuvel, J. J. M. W., Koenderink, J. B., Pennings, S. W. C., Russel, F. G. M.
, & Masereeuw, R. (2013).
Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity.
Current Pharmaceutical Design,
19(15), 2698-707.
https://doi.org/10.2174/1381612811319150004Peters, E., van Elsas, A., Heemskerk, S., Jonk, L., van der Hoeven, J., Arend, J.
, Masereeuw, R., & Pickkers, P. (2013).
Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury.
Journal of Pharmacology and Experimental Therapeutics,
344(1), 2-7.
https://doi.org/10.1124/jpet.112.198226Wever, K. E.
, Masereeuw, R., Wagener, F. A., Verweij, V. G. M., Peters, J. G. P., Pertijs, J. C. L. M., Van der Vliet, J. A., Warlé, M. C., & Rongen, G. A. (2013).
Humoral signalling compounds in remote ischaemic preconditioning of the kidney, a role for the opioid receptor.
Nephrology Dialysis Transplantation,
28(7), 1721-32.
https://doi.org/10.1093/ndt/gfs601van Swelm, R. P. L., Laarakkers, C. M. M., Pertijs, J. C. L. M., Verweij, V.
, Masereeuw, R., & Russel, F. G. M. (2013).
Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice.
Toxicology and Applied Pharmacology,
269(2), 141-9.
https://doi.org/10.1016/j.taap.2013.03.005Peters, H. P. E., Laarakkers, C. M. M., Pickkers, P.
, Masereeuw, R., Boerman, O. C., Eek, A., Cornelissen, E. A. M., Swinkels, D. W., & Wetzels, J. F. M. (2013).
Tubular reabsorption and local production of urine hepcidin-25.
BMC Nephrology,
14, 70.
https://doi.org/10.1186/1471-2369-14-70Dankers, A. C. A., Mutsaers, H. A. M., Dijkman, H. B. P. M., van den Heuvel, L. P., Hoenderop, J. G., Sweep, F. C. G. J., Russel, F. G. M.
, & Masereeuw, R. (2013).
Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP).
Biochimica et Biophysica Acta,
1832(10), 1715-22.
https://doi.org/10.1016/j.bbadis.2013.05.002Martines, A. M. F.
, Masereeuw, R., Tjalsma, H., Hoenderop, J. G., Wetzels, J. F. M., & Swinkels, D. W. (2013).
Iron metabolism in the pathogenesis of iron-induced kidney injury.
Nature Reviews. Nephrology,
9(7), 385-98.
https://doi.org/10.1038/nrneph.2013.98van Geffen, M., Mathijssen, N. C. J., Holme, P. A., Laros-van Gorkom, B. A. P., van Kraaij, M. G. J.
, Masereeuw, R., Peyvandi, F., & van Heerde, W. L. (2013).
Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients.
Thrombosis Research,
132(1), 116-22.
https://doi.org/10.1016/j.thromres.2013.04.021Schophuizen, C. M. S., Wilmer, M. J., Jansen, J., Gustavsson, L., Hilgendorf, C., Hoenderop, J. G. J., van den Heuvel, L. P.
, & Masereeuw, R. (2013).
Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter.
Pflugers Archiv-European Journal of Physiology,
465(12), 1701-14.
https://doi.org/10.1007/s00424-013-1307-zvan Swelm, R. P. L., Laarakkers, C. M. M., Kooijmans-Otero, M., de Jong, E. M. G. J.
, Masereeuw, R., & Russel, F. G. M. (2013).
Biomarkers for methotrexate-induced liver injury: urinary protein profiling of psoriasis patients.
Toxicology Letters,
221(3), 219-24.
https://doi.org/10.1016/j.toxlet.2013.06.234Mathijssen, N. C. J.
, Masereeuw, R., Holme, P. A., van Kraaij, M. G. J., Laros-van Gorkom, B. A. P., Peyvandi, F., & van Heerde, W. L. (2013).
Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect.
Thrombosis Research,
132(2), 256-62.
https://doi.org/10.1016/j.thromres.2013.05.027Hosper, N. A., van den Berg, P. P., de Rond, S., Popa, E. R., Wilmer, M. J.
, Masereeuw, R., & Bank, R. A. (2013).
Epithelial-to-mesenchymal transition in fibrosis: collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition.
Experimental Cell Research,
319(19), 3000-9.
https://doi.org/10.1016/j.yexcr.2013.07.014Mutsaers, H. A. M., Engelke, U. F. H., Wilmer, M. J. G., Wetzels, J. F. M., Wevers, R. A., van den Heuvel, L. P., Hoenderop, J. G.
, & Masereeuw, R. (2013).
Optimized metabolomic approach to identify uremic solutes in plasma of stage 3-4 chronic kidney disease patients.
PLoS One,
8(8), e71199.
https://doi.org/10.1371/journal.pone.0071199Dankers, A. C. A.
, Roelofs, M. J. E., Piersma, A. H., Sweep, F. C. G. J., Russel, F. G. M.
, van den Berg, M., van Duursen, M. B. M., & Masereeuw, R. (2013).
Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro.
Toxicological Sciences,
136(2), 382-391.
https://doi.org/10.1093/toxsci/kft198El-Sheikh, A. A. K., Greupink, R., Wortelboer, H. M., van den Heuvel, J. J. M. W., Schreurs, M., Koenderink, J. B.
, Masereeuw, R., & Russel, F. G. M. (2013).
Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4.
Translational Research,
162(6), 398-409.
https://doi.org/10.1016/j.trsl.2013.08.0032012
Wetenschappelijke publicaties
Dardikh, M., Albert, T.
, Masereeuw, R., Oldenburg, J., Novakova, I., van Heerde, W. L., & Verbruggen, B. (2012).
Low-titre inhibitors, undetectable by the Nijmegen assay, reduce factor VIII half-life after immune tolerance induction.
Journal of Thrombosis and Haemostasis,
10(4), 706-8.
https://doi.org/10.1111/j.1538-7836.2012.04645.xEngbersen, R.
, Masereeuw, R., van Gestel, M. A., Siero, H. L. M., Moons, M. M., Smits, P., & Russel, F. G. M. (2012).
Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels.
European Journal of Pharmacology,
681(1-3), 75-9.
https://doi.org/10.1016/j.ejphar.2012.02.006Wever, K. E., Menting, T. P., Rovers, M., van der Vliet, J. A., Rongen, G. A.
, Masereeuw, R., Ritskes-Hoitinga, M., Hooijmans, C. R., & Warlé, M. (2012).
Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis.
PLoS One,
7(2), e32296.
https://doi.org/10.1371/journal.pone.0032296Dankers, A. C. A., Sweep, F. C. G. J., Pertijs, J. C. L. M., Verweij, V., van den Heuvel, J. J. M. W., Koenderink, J. B., Russel, F. G. M.
, & Masereeuw, R. (2012).
Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones.
Cell and Tissue Research,
349(2), 551-63.
https://doi.org/10.1007/s00441-012-1417-5van Swelm, R. P. L., Laarakkers, C. M. M., Blous, L., Peters, J. G. P., Blaney Davidson, E. N., van der Kraan, P. M., Swinkels, D. W.
, Masereeuw, R., & Russel, F. G. M. (2012).
Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis.
Toxicological Sciences,
129(1), 225-33.
https://doi.org/10.1093/toxsci/kfs176Ramakers, B. P., Wever, K. E., Kox, M., van den Broek, P. H., Mbuyi, F., Rongen, G.
, Masereeuw, R., van der Hoeven, J. G., Smits, P., Riksen, N. P., & Pickkers, P. (2012).
How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo.
Critical Care Medicine,
40(9), 2609-16.
https://doi.org/10.1097/CCM.0b013e318259205bWever, K. E., Menting, T.
, Masereeuw, R., van der Vliet, J. A., Rongen, G. A., & Warlé, M. C. (2012).
Local and remote ischemic postconditionings have synergistic protective effects on renal ischemia-reperfusion injury.
Transplantation,
94(1), e1-2.
https://doi.org/10.1097/TP.0b013e318257ad76Masereeuw, R., & Russel, F. G. M. (2012).
Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules.
The AAPS journal,
14(4), 883-94.
https://doi.org/10.1208/s12248-012-9404-z Dieteren, C. E. J., Koopman, W. J. H., Swarts, H. G., Peters, J. G. P., Maczuga, P., van Gemst, J. J.
, Masereeuw, R., Smeitink, J. A. M., Nijtmans, L. G. J., & Willems, P. H. G. M. (2012).
Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis.
Journal of Biological Chemistry,
287(50), 41851-60.
https://doi.org/10.1074/jbc.M112.391151van Swelm, R. P. L., Laarakkers, C. M. M., van der Kuur, E. C., Morava-Kozicz, E., Wevers, R. A., Augustijn, K. D., Touw, D. J., Sandel, M. H.
, Masereeuw, R., & Russel, F. G. M. (2012).
Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice.
PLoS One,
7(11), e49524.
https://doi.org/10.1371/journal.pone.00495242011
Wetenschappelijke publicaties
Tjalsma, H., Laarakkers, C. M. M., van Swelm, R. P. L., Theurl, M., Theurl, I., Kemna, E. H., van der Burgt, Y. E. M., Venselaar, H.
, Dutilh, B. E., Russel, F. G. M., Weiss, G.
, Masereeuw, R., Fleming, R. E., & Swinkels, D. W. (2011).
Mass Spectrometry Analysis of Hepcidin Peptides in Experimental Mouse Models.
PLoS One,
6(3), Article e16762.
https://doi.org/10.1371/journal.pone.0016762Schreuder, M. F., Bueters, R. R., Huigen, M. C., Russel, F. G. M.
, Masereeuw, R., & van den Heuvel, L. P. (2011).
Effect of drugs on renal development.
Clinical Journal of the American Society of Nephrology,
6(1), 212-7.
https://doi.org/10.2215/CJN.04740510Peeters, K., Wilmer, M. J., Schoeber, J. P., Reijnders, D., Heuvel, L. P. V. D.
, Masereeuw, R., & Levtchenko, E. (2011).
Role of p-glycoprotein expression and function in cystinotic renal proximal tubular cells.
Molecular Pharmaceutics,
3(4), 782-92.
https://doi.org/10.3390/pharmaceutics3040782Rennings, A. J., Russel, F. G., Li, Y., Deen, P. M.
, Masereeuw, R., Tack, C. J., & Smits, P. (2011).
Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study.
Clinical Pharmacology and Therapeutics,
89(4), 587-94.
https://doi.org/10.1038/clpt.2010.360Wilmer, M. J., Kluijtmans, L. A. J., van der Velden, T. J., Willems, P. H., Scheffer, P. G.
, Masereeuw, R., Monnens, L. A., van den Heuvel, L. P., & Levtchenko, E. N. (2011).
Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells.
Biochimica et Biophysica Acta,
1812(6), 643-51.
https://doi.org/10.1016/j.bbadis.2011.02.010van den Boogaard, M., van Swelm, R. P., Russel, F. G., Heemskerk, S., van der Hoeven, J. G.
, Masereeuw, R., & Pickkers, P. (2011).
Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients.
Proteome Science [E],
9, 13.
https://doi.org/10.1186/1477-5956-9-13Wever, K. E., Warlé, M. C., Wagener, F. A., van der Hoorn, J. W.
, Masereeuw, R., van der Vliet, J. A., & Rongen, G. A. (2011).
Remote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: the role of adenosine.
Nephrology Dialysis Transplantation,
26(10), 3108-17.
https://doi.org/10.1093/ndt/gfr103Mutsaers, H. A. M., van den Heuvel, L. P., Ringens, L. H. J., Dankers, A. C. A., Russel, F. G. M., Wetzels, J. F. M., Hoenderop, J. G.
, & Masereeuw, R. (2011).
Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.
PLoS One,
6(4), e18438.
https://doi.org/10.1371/journal.pone.0018438Prevoo, B., Miller, D. S., van de Water, F. M., Wever, K. E., Russel, F. G. M., Flik, G.
, & Masereeuw, R. (2011).
Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule.
Journal of Pharmacology and Experimental Therapeutics,
338(1), 362-71.
https://doi.org/10.1124/jpet.111.179689Wever, K. E., Wagener, F. A. D. T. G., Frielink, C., Boerman, O. C., Scheffer, G. J., Allison, A.
, Masereeuw, R., & Rongen, G. A. (2011).
Diannexin protects against renal ischemia reperfusion injury and targets phosphatidylserines in ischemic tissue.
PLoS One,
6(8), e24276.
https://doi.org/10.1371/journal.pone.0024276Mutsaers, H. A. M., Wilmer, M. J. G., van den Heuvel, L. P., Hoenderop, J. G.
, & Masereeuw, R. (2011).
Basolateral transport of the uraemic toxin p-cresyl sulfate: role for organic anion transporters? Nephrology Dialysis Transplantation,
26(12), 4149.
https://doi.org/10.1093/ndt/gfr5622010
Wetenschappelijke publicaties
Wilmer, M. J., Saleem, M. A.
, Masereeuw, R., Ni, L., van der Velden, T. J., Russel, F. G., Mathieson, P. W., Monnens, L. A., van den Heuvel, L. P., & Levtchenko, E. N. (2010).
Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters.
Cell and Tissue Research,
339(2), 449-57.
https://doi.org/10.1007/s00441-009-0882-yHeemskerk, S., Peters, J. G. P., Louisse, J.
, Sagar, S., Russel, F. G. M.
, & Masereeuw, R. (2010).
Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha.
Journal of Biomedicine and Biotechnology,
2010, 525180.
https://doi.org/10.1155/2010/525180Vegt, E., de Jong, M., Wetzels, J. F. M.
, Masereeuw, R., Melis, M., Oyen, W. J. G., Gotthardt, M., & Boerman, O. C. (2010).
Renal toxicity of radiolabeled peptides and antibody fragments: mechanisms, impact on radionuclide therapy, and strategies for prevention.
Journal of Nuclear Medicine,
51(7), 1049-58.
https://doi.org/10.2967/jnumed.110.075101Reichel, V., Kläs, J., Fricker, G.
, & Masereeuw, R. (2010).
Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus.
Journal of Neurochemistry,
115(1), 200-8.
https://doi.org/10.1111/j.1471-4159.2010.06915.xHuls, M., Schoeber, J. P. H., Verfaillie, C. M., Luttun, A., Ulloa-Montoya, F., Menke, A. L., van Bolderen, L. R., Woestenenk, R. M., Merkx, G. F. M., Wetzels, J. F. M., Russel, F. G. M.
, & Masereeuw, R. (2010).
Deficiency of either P-glycoprotein or breast cancer resistance protein protect against acute kidney injury.
Cell Transplantation,
19(9), 1195-208.
https://doi.org/10.3727/096368910X5044782009
Wetenschappelijke publicaties
Huls, M., Russel, F. G. M.
, & Masereeuw, R. (2009).
The role of ATP binding cassette transporters in tissue defense and organ regeneration.
Journal of Pharmacology and Experimental Therapeutics,
328(1), 3-9.
https://doi.org/10.1124/jpet.107.132225Heemskerk, S.
, Masereeuw, R., Moesker, O., Bouw, M. P. W. J. M., van der Hoeven, J. G., Peters, W. H. M., Russel, F. G. M., APSEP Study Group, & Pickkers, P. (2009).
Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.
Critical Care Medicine,
37(2), 417-23, e1.
https://doi.org/10.1097/CCM.0b013e31819598afHuynh, L., Masereeuw, R., Friedberg, T., Ingelman-Sundberg, M., & Manivet, P. (2009). In silico platform for xenobiotics ADME-T pharmacological properties modeling and prediction. Part I: Beyond the reduction of animal model use. Drug Discovery Today, 14(7-8), 401-5.
Heemskerk, S.
, Masereeuw, R., Russel, F. G. M., & Pickkers, P. (2009).
Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury.
Nature Reviews. Nephrology,
5(11), 629-40.
https://doi.org/10.1038/nrneph.2009.155Masereeuw, R. (2009). Contribution of bone marrow-derived cells in renal repair after acute kidney injury. Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 61(4), 373-84.
2008
Wetenschappelijke publicaties
Heemskerk, S., van Haren, F. M. P., Foudraine, N. A., Peters, W. H. M., van der Hoeven, J. G., Russel, F. G. M.
, Masereeuw, R., & Pickkers, P. (2008).
Short-term beneficial effects of methylene blue on kidney damage in septic shock patients.
Intensive Care Medicine,
34(2), 350-4.
https://doi.org/10.1007/s00134-007-0867-9Huls, M., Brown, C. D. A., Windass, A. S., Sayer, R., van den Heuvel, J. J. M. W., Heemskerk, S., Russel, F. G. M.
, & Masereeuw, R. (2008).
The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane.
Kidney International,
73(2), 220-5.
https://doi.org/10.1038/sj.ki.5002645Denissen, N. H. A. M., Peters, J. G. P.
, Masereeuw, R., & Barrera, P. (2008).
Can sulfasalazine therapy induce or exacerbate Wegener's granulomatosis? Scandinavian Journal of Rheumatology,
37(1), 72-4.
https://doi.org/10.1080/03009740701607117Heemskerk, S., Wouterse, A. C., Russel, F. G. M.
, & Masereeuw, R. (2008).
Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia.
European Journal of Pharmacology,
584(2-3), 390-7.
https://doi.org/10.1016/j.ejphar.2008.02.006Russel, F. G. M., Koenderink, J. B.
, & Masereeuw, R. (2008).
Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules.
Trends in Pharmacological Sciences,
29(4), 200-7.
https://doi.org/10.1016/j.tips.2008.01.006Huls, M., Russel, F. G. M.
, & Masereeuw, R. (2008).
Insights into the role of bone marrow-derived stem cells in renal repair.
Kidney & Blood Pressure Research,
31(2), 104-10.
https://doi.org/10.1159/000121387Vegt, E., van Eerd, J. E. M., Eek, A., Oyen, W. J. G., Wetzels, J. F. M., de Jong, M., Russel, F. G. M.
, Masereeuw, R., Gotthardt, M., & Boerman, O. C. (2008).
Reducing renal uptake of radiolabeled peptides using albumin fragments.
Journal of Nuclear Medicine,
49(9), 1506-11.
https://doi.org/10.2967/jnumed.108.0532492007
Wetenschappelijke publicaties
Wever, K. E., Masereeuw, R.
, Masereeuw, R., Miller, D. S., Hang, X. M., & Flik, G. (2007).
Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport.
American Journal of Physiology-Renal Physiology,
292(1), F38-46.
https://doi.org/10.1152/ajprenal.00479.2005van de Water, F. M., Boleij, J. M., Peters, J. G. P., Russel, F. G. M.
, & Masereeuw, R. (2007).
Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines.
European Journal of Pharmaceutical Sciences,
30(1), 36-44.
https://doi.org/10.1016/j.ejps.2006.09.008Heemskerk, S., van Koppen, A., van den Broek, L., Poelen, G. J. M., Wouterse, A. C., Dijkman, H. B. P. M., Russel, F. G. M.
, & Masereeuw, R. (2007).
Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia.
Pflugers Archiv-European Journal of Physiology,
454(2), 321-34.
https://doi.org/10.1007/s00424-007-0210-xVanhoutte, K. J. A., Laarakkers, C., Marchiori, E., Pickkers, P., Wetzels, J. F. M., Willems, J. L., van den Heuvel, L. P., Russel, F. G. M.
, & Masereeuw, R. (2007).
Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: evaluation with computational analytical tools.
Nephrology Dialysis Transplantation,
22(10), 2932-43.
https://doi.org/10.1093/ndt/gfm170Heemskerk, S.
, Masereeuw, R., van der Hoeven, H., & Pickkers, P. (2007).
Renal effects of nitric oxide during sepsis: another two-edged sword? American Journal of Respiratory and Critical Care Medicine,
176(4), 419-20; author reply 420.
https://doi.org/10.1164/ajrccm.176.4.419Huls, M., Kramers, C., Levtchenko, E. N., Wilmer, M. J. G., Dijkman, H. B. P. M., Kluijtmans, L. A. J., van der Hoorn, J. W. A., Russel, F. G. M.
, & Masereeuw, R. (2007).
P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury.
Kidney International,
72(10), 1233-41.
https://doi.org/10.1038/sj.ki.5002522Reichel, V.
, Masereeuw, R., van den Heuvel, J. J. M. W., Miller, D. S., & Fricker, G. (2007).
Transport of a fluorescent cAMP analog in teleost proximal tubules.
American journal of physiology. Regulatory integrative comparative physiology,
293(6), R2382-9.
https://doi.org/10.1152/ajpregu.00029.20072006
Wetenschappelijke publicaties
Van Eerd, J. E. M., Vegt, E., Wetzels, J. F. M., Russel, F. G. M., Masereeuw, R., Corstens, F. H. M., Boerman, O. C., & Oyen, W. J. G. (2006). Reply: Inhibition of kidney uptake of radiolabeled somatostatin analogs: Amino acids or gelofusine? [2]. Journal of Nuclear Medicine, 47(10).
Vegt, E., Wetzels, J. F. M., Russel, F. G. M., Masereeuw, R., Boerman, O. C., van Eerd, J. E., Corstens, F. H. M., & Oyen, W. J. G. (2006). Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin. Journal of Nuclear Medicine, 47(3), 432-6.
van Eerd, J. E. M., Vegt, E., Wetzels, J. F. M., Russel, F. G. M., Masereeuw, R., Corstens, F. H. M., Oyen, W. J. G., & Boerman, O. C. (2006). Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats. Journal of Nuclear Medicine, 47(3), 528-33.
Huls, M., van den Heuvel, J. J. M. W., Dijkman, H. B. P. M., Russel, F. G. M.
, & Masereeuw, R. (2006).
ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney.
Kidney International,
69(12), 2186-93.
https://doi.org/10.1038/sj.ki.5000407van de Water, F. M., Boerman, O. C., Wouterse, A. C., Peters, J. G. P., Russel, F. G. M.
, & Masereeuw, R. (2006).
Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules.
Drug Metabolism and Disposition,
34(8), 1393-7.
https://doi.org/10.1124/dmd.106.009555Notenboom, S., Wouterse, A. C., Peters, B., Kuik, L. H., Heemskerk, S., Russel, F. G. M.
, & Masereeuw, R. (2006).
Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure.
Journal of Pharmacology and Experimental Therapeutics,
318(3), 1194-202.
https://doi.org/10.1124/jpet.106.104547van de Water, F. M., Russel, F. G. M.
, & Masereeuw, R. (2006).
Regulation and expression of endothelin-1 (ET-1) and ET-receptors in rat epithelial cells of renal and intestinal origin.
Pharmacological Research,
54(6), 429-35.
https://doi.org/10.1016/j.phrs.2006.08.006Heemskerk, S., Pickkers, P., Bouw, M. P. W. J. M., Draisma, A., van der Hoeven, J. G., Peters, W. H. M., Smits, P., Russel, F. G. M.
, & Masereeuw, R. (2006).
Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.
Clinical Journal of the American Society of Nephrology,
1(4), 853-62.
https://doi.org/10.2215/CJN.004902062005
Wetenschappelijke publicaties
Engbersen, R.
, Masereeuw, R., van Gestel, M. A., van der Logt, E. M. J., Smits, P., & Russel, F. G. M. (2005).
Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism.
British Journal of Pharmacology,
145(8), 1069-75.
https://doi.org/10.1038/sj.bjp.0706275Notenboom, S., Miller, D. S., Kuik, L. H., Smits, P., Russel, F. G. M.
, & Masereeuw, R. (2005).
Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity.
Journal of Pharmacology and Experimental Therapeutics,
315(2), 912-20.
https://doi.org/10.1124/jpet.105.089094van de Water, F. M.
, Masereeuw, R., & Russel, F. G. M. (2005).
Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions.
Drug Metabolism Reviews,
37(3), 443-71.
https://doi.org/10.1080/036025305002052752004
Wetenschappelijke publicaties
Notenboom, S., Miller, D. S., Smits, P., Russel, F. G. M.
, & Masereeuw, R. (2004).
Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule.
American Journal of Physiology-Renal Physiology,
287(1), F33-8.
https://doi.org/10.1152/ajprenal.00443.2003Mathijssen, N. C. J.
, Masereeuw, R., Verbeek, K., Lavergne, J. M., Costa, J.-M., van Heerde, W. L., & Nováková, I. R. O. (2004).
Prophylactic effect of recombinant factor VIIa in factor VII deficient patients.
British Journal of Haematology,
125(4), 494-9.
https://doi.org/10.1111/j.1365-2141.2004.04942.x2003
Wetenschappelijke publicaties
Terlouw, S. A., Masereeuw, R., & Russel, F. G. M. (2003). Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport. Biochemical Pharmacology, 65(9), 1393-405.
de Gier, R. P. E., Feitz, W. F. J., Masereeuw, R., Wouterse, A. C., Smits, D., & Russel, F. G. M. (2003). Anionic and cationic drug secretion in the isolated perfused rat kidney after neonatal surgical induction of ureteric obstruction. BJU International, 92(4), 452-8.
Masereeuw, R., Notenboom, S., Smeets, P. H. E., Wouterse, A. C., & Russel, F. G. M. (2003). Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats. Journal of the American Society of Nephrology, 14(11), 2741-9.
2002
Wetenschappelijke publicaties
Miller, D. S.
, Masereeuw, R., & Karnaky, K. J. (2002).
Regulation of MRP2-mediated transport in shark rectal salt gland tubules.
American journal of physiology. Regulatory integrative comparative physiology,
282(3), R774-81.
https://doi.org/10.1152/ajpregu.00333.2001Notenboom, S., Miller, D. S., Smits, P., Russel, F. G. M.
, & Masereeuw, R. (2002).
Role of NO in endothelin-regulated drug transport in the renal proximal tubule.
American Journal of Physiology-Renal Physiology,
282(3), F458-64.
https://doi.org/10.1152/ajprenal.00173.2001Terlouw, S. A., Graeff, C., Smeets, P. H. E., Fricker, G., Russel, F. G. M., Masereeuw, R., & Miller, D. S. (2002). Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule. Journal of Pharmacology and Experimental Therapeutics, 301(2), 578-85.
2001
Wetenschappelijke publicaties
Terlouw, S. A., Masereeuw, R., Russel, F. G., & Miller, D. S. (2001). Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux. Molecular Pharmacology, 59(6), 1433-40.
Terlouw, S. A.
, Masereeuw, R., van den Broek, P. H., Notenboom, S., & Russel, F. G. (2001).
Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells.
British Journal of Pharmacology,
134(5), 931-8.
https://doi.org/10.1038/sj.bjp.0704284Smeets, M., Raymakers, R., Muus, P., Vierwinden, G., Linssen, P., Masereeuw, R., & de Witte, T. (2001). Cyclosporin increases cellular idarubicin and idarubicinol concentrations in relapsed or refractory AML mainly due to reduced systemic clearance. Leukemia, 15(1), 80-8.
2000
Wetenschappelijke publicaties
Masereeuw, R., Terlouw, S. A., van Aubel, R. A., Russel, F. G., & Miller, D. S. (2000). Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule. Molecular Pharmacology, 57(1), 59-67.
Terlouw, S. A., Tanriseven, O., Russel, F. G., & Masereeuw, R. (2000). Metabolite anion carriers mediate the uptake of the anionic drug fluorescein in renal cortical mitochondria. Journal of Pharmacology and Experimental Therapeutics, 292(3), 968-73.
van Oosterhout, Y. V., van Emst, L., Schattenberg, A. V., Tax, W. J., Ruiter, D. J., Spits, H., Nagengast, F. M., Masereeuw, R., Evers, S., de Witte, T., & Preijers, F. W. (2000). A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease. Blood, 95(12), 3693-701.
Van Aubel, R. A., Masereeuw, R., & Russel, F. G. (2000). Molecular pharmacology of renal organic anion transporters. American Journal of Physiology-Renal Physiology, 279(2), F216-32.
Masereeuw, R., van Pelt, A. P., van Os, S. H., Willems, P. H., Smits, P., & Russel, F. G. (2000).
Probenecid interferes with renal oxidative metabolism: a potential pitfall in its use as an inhibitor of drug transport.
British Journal of Pharmacology,
131(1), 57-62.
https://doi.org/10.1038/sj.bjp.0703541 Van Aubel, R. A., Peters, J. G., Masereeuw, R., Van Os, C. H., & Russel, F. G. (2000). Multidrug resistance protein mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate. American Journal of Physiology-Renal Physiology, 279(4), F713-7.
1999
Wetenschappelijke publicaties
Masereeuw, R., Moons, M. M., Toomey, B. H., Russel, F. G., & Miller, D. S. (1999). Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. Journal of Pharmacology and Experimental Therapeutics, 289(2), 1104-11.
1998
Wetenschappelijke publicaties
Karnaky, K. J., Masereeuw, R., Henson, J., & Miller, D. S. (1998). Active xenobiotic excretion by Elasmo-branch rectal salt gland (RG) tubules. FASEB Journal, 12(5).
Miller, D. S., Masereeuw, R., Henson, J., & Karnaky, K. J. (1998). Excretory transport of xenobiotics by dogfish shark rectal gland tubules. American Journal of Physiology, 275(3 Pt 2), R697-705.
Masereeuw, R., Moons, M. M., & Russel, F. G. (1998). Disposition of 4-methylbenzoylglycine in rat isolated perfused kidney and effects of hippurates on renal mitochondrial metabolism. Journal of Pharmacy and Pharmacology, 50(12), 1397-404.
1997
Wetenschappelijke publicaties
Masereeuw, R., Moons, M. M.
, Smits, P., & Russel, F. G. M. (1997).
Excretion and accumulation of diatrizoate in the isolated perfused rat kidney.
European Journal of Pharmaceutical Sciences,
5(5), 295-301.
https://doi.org/10.1016/S0928-0987(97)00024-9 Masereeuw, R., Moons, W. M., & Russel, F. G. (1997). Saturable accumulation and diuretic activity of hydrochlorothiazide in the isolated perfused rat kidney. Pharmacology, 54(1), 33-42.
Masereeuw, R., Moons, M. M., & Russel, F. G. (1997). Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system. European Journal of Pharmacology, 321(3), 315-23.
1996
Wetenschappelijke publicaties
Masereeuw, R., Russel, F. G. M., & Miller, D. S. (1996). Active, na-lndependent, organic anion secretion in killifish renal proximal tubules. FASEB Journal, 10(3).
Masereeuw, R., Moons, M. M., & Russel, F. G. (1996). Renal excretion and accumulation kinetics of 2-methylbenzoylglycine in the isolated perfused rat kidney. Journal of Pharmacy and Pharmacology, 48(6), 560-5.
Masereeuw, R., Moons, M. M., Smits, P., & Russel, F. G. (1996). Glomerular filtration and saturable absorption of iohexol in the rat isolated perfused kidney. British Journal of Pharmacology, 119(1), 57-64.
Masereeuw, R., Saleming, W. C., Miller, D. S., & Russel, F. G. (1996). Interaction of fluorescein with the dicarboxylate carrier in rat kidney cortex mitochondria. Journal of Pharmacology and Experimental Therapeutics, 279(3), 1559-65.
Masereeuw, R., Russel, F. G., & Miller, D. S. (1996). Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy. American Journal of Physiology, 271(6 Pt 2), F1173-82.
1994
Wetenschappelijke publicaties
Masereeuw, R., Jaehde, U., Langemeijer, M. W., de Boer, A. G., & Breimer, D. D. (1994). In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors. Pharmaceutical Research, 11(2), 324-30.
Jaehde, U., Masereeuw, R., De Boer, A. G., Fricker, G., Nagelkerke, J. F., Vonderscher, J., & Breimer, D. D. (1994). Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells. Pharmaceutical Research, 11(3), 442-8.
Masereeuw, R., van den Bergh, E. J., Bindels, R. J., & Russel, F. G. (1994). Characterization of fluorescein transport in isolated proximal tubular cells of the rat: evidence for mitochondrial accumulation. Journal of Pharmacology and Experimental Therapeutics, 269(3), 1261-7.