Prof. dr. R. (Roos) Masereeuw

David de Wiedgebouw
Universiteitsweg 99
Kamer 2.78
3584 CG Utrecht

Prof. dr. R. (Roos) Masereeuw

Vice Dean
Algemeen FBW
Professor
Pharmacology
+31 30 253 3529
r.masereeuw@uu.nl

Publications

2024

Scholarly publications

Orge, I. D., Nogueira Pinto, H., Silva, M. A., Bidarra, S. J., Ferreira, S. A., Calejo, I., Masereeuw, R., Mihăilă, S. M., & Barrias, C. C. (2024). Vascular units as advanced living materials for bottom-up engineering of perfusable 3D microvascular networks. Bioactive Materials, 38, 499-511. https://doi.org/10.1016/j.bioactmat.2024.05.021
Janssen, R., Benito‐Zarza, L., Cleijpool, P., Valverde, M. G., Mihăilă, S. M., Bastiaan‐Net, S., Garssen, J., Willemsen, L. E. M., & Masereeuw, R. (2024). Biofabrication Directions in Recapitulating the Immune System‐on‐a‐Chip. Advanced healthcare materials, Article 2304569. Advance online publication. https://doi.org/10.1002/adhm.202304569
Wang, Z., Xing, C., Laan, L. J. W. V. D., Verstegen, M. M. A., Spee, B., & Masereeuw, R. (2024). Cholangiocyte organoids to study drug-induced injury. Stem cell research & therapy, 15(1), 1-15. Article 78. https://doi.org/10.1186/s13287-024-03692-6
https://dspace.library.uu.nl/bitstream/handle/1874/437526/s13287-024-03692-6.pdf?sequence=1
Ciarimboli, G., Masereeuw, R., & Oswald, S. (2024). Editorial: Transporters: a hitchhiker's guide to physiology, toxicology, and pharmacology-TransportDays 2022. Frontiers in Pharmacology, 15, Article 1365106. https://doi.org/10.3389/fphar.2024.1365106
https://dspace.library.uu.nl/bitstream/handle/1874/437756/fphar-15-1365106.pdf?sequence=1
Barnes, D. A., Firman, J. W., Belfield, S. J., Cronin, M. T. D., Vinken, M., Janssen, M. J., & Masereeuw, R. (2024). Development of an adverse outcome pathway network for nephrotoxicity. Archives of Toxicology, 98(3), 929-942. https://doi.org/10.1007/s00204-023-03637-7
https://dspace.library.uu.nl/bitstream/handle/1874/437528/s00204-023-03637-7.pdf?sequence=1
Janssen, R., de Kleer, J. W. M., Heming, B., Bastiaan-Net, S., Garssen, J., Willemsen, L. E. M., & Masereeuw, R. (2024). Food allergen sensitization on a chip: the gut-immune-skin axis. Trends in Biotechnology, 42(1), 119-134. https://doi.org/10.1016/j.tibtech.2023.07.005

2023

Scholarly publications

Yang, Y., Mihajlovic, M., & Masereeuw, R. (2023). Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis. Preprints.org. https://doi.org/10.20944/preprints202308.0733.v1
https://dspace.library.uu.nl/bitstream/handle/1874/438121/preprints202308.0733.v1.pdf?sequence=1
Wang, Z., Xing, C., Laan, L. J. W. V. D., Verstegen, M. M. A., Spee, B., & Masereeuw, R. (2023). Cholangiocyte Organoids to Model Chlorpromazine-Induced Bile Duct Injury. (pp. 1-26). Research Square. https://doi.org/10.21203/rs.3.rs-3405852/v1
https://dspace.library.uu.nl/bitstream/handle/1874/436051/c1fab71e-11bf-47c7-b602-bc568ac7295f.pdf?sequence=1
Garvi, E. S., Slobbe, G. V. D., Zaal, E. A., Baaij, J. H. F. D., Hoenderop, J., Masereeuw, R., Janssen, M. J., & Genderen, A. M. V. (2023). A novel KCNJ16 kidney organoid model recapitulates the disease phenotype and shows restoration of lipid accumulation upon treatment with statins. (pp. 1-37). bioRxiv. https://doi.org/10.1101/2023.12.22.572750
Faria, J., Calcat-i-Cervera, S., Skovronova, R., Broeksma, B. C., Berends, A. J., Zaal, E. A., Bussolati, B., O’Brien, T., Mihăilă, S. M., & Masereeuw, R. (2023). Mesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury. Stem cell research & therapy, 14(1), 1-19. Article 353. https://doi.org/10.1186/s13287-023-03563-6
https://dspace.library.uu.nl/bitstream/handle/1874/434991/s13287-023-03563-6.pdf?sequence=1
Slingerland, C. J., Lysenko, V., Chaudhuri, S., Wesseling, C. M. J., Barnes, D., Masereeuw, R., & Martin, N. I. (2023). Semisynthetic polymyxins with potent antibacterial activity and reduced kidney cell toxicity. RSC Medicinal Chemistry, 14(11), 2417-2425. https://doi.org/10.1039/D3MD00456B
https://dspace.library.uu.nl/bitstream/handle/1874/434429/d3md00456b.pdf?sequence=1
Ahmed, S., Vries, J. C. D., Lu, J., Stuart, M. H. V., Mihăilă, S. M., Vernooij, R. W. M., Masereeuw, R., & Gerritsen, K. G. F. (2023). Animal Models for Studying Protein-Bound Uremic Toxin Removal—A Systematic Review. International Journal of Molecular Sciences, 24(17), Article 13197. https://doi.org/10.3390/ijms241713197
Yang, Y., Mihajlovic, M., & Masereeuw, R. (2023). Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis. Biomedicines, 11(9), Article 2408. https://doi.org/10.3390/biomedicines11092408
Faria, J., Ahmed, S., Stamatialis, D., Verhaar, M. C., Masereeuw, R., Gerritsen, K. G. F., & Mihăilă, S. M. (2023). Bioengineered Kidney Tubules Efficiently Clear Uremic Toxins in Experimental Dialysis Conditions. International Journal of Molecular Sciences, 24(15), Article 12435. https://doi.org/10.3390/ijms241512435
Keuper-Navis, M., Walles, M., Poller, B., Myszczyszyn, A., van der Made, T. K., Donkers, J., Amirabadi, H. E., Wilmer, M. J., Aan, S., Spee, B., Masereeuw, R., & van de Steeg, E. (2023). The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development. Pharmacological Research, 195, Article 106853. https://doi.org/10.1016/j.phrs.2023.106853
Ramada, D. L., de Vries, J., Vollenbroek, J., Noor, N., Ter Beek, O., Mihaila, S., Wieringa, F., Masereeuw, R., Gerritsen, K. G. F., & Stamatialis, D. (2023). Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges. Nature Reviews Nephrology, 19(8), 481-490. https://doi.org/10.1038/s41581-023-00726-9
Faucher, Q., van der Made, T. K., De Lange, E., & Masereeuw, R. (2023). Blood-brain barrier perturbations by uremic toxins: key contributors in chronic kidney disease-induced neurological disorders? European Journal of Pharmaceutical Sciences, 187, 1-8. Article 106462. https://doi.org/10.1016/j.ejps.2023.106462
Yang, Y., Mihajlovic, M., Janssen, M. J., & Masereeuw, R. (2023). The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells. Toxins, 15(4), 1-18. Article 242. https://doi.org/10.3390/toxins15040242
Toropov, A. A., Barnes, D. A., Toropova, A. P., Roncaglioni, A., Irvine, A. R., Masereeuw, R., & Benfenati, E. (2023). CORAL Models for Drug-Induced Nephrotoxicity. Toxics, 11(4), Article 293. https://doi.org/10.3390/toxics11040293
Yengej, F. A. Y., Jansen, J., Ammerlaan, C. M. E., Dilmen, E., Casellas, C. P., Masereeuw, R., Hoenderop, J. G., Smeets, B., Rookmaaker, M. B., Verhaar, M. C., & Clevers, H. (2023). Tubuloid culture enables long-term expansion of functional human kidney tubule epithelium from iPSC-derived organoids. Proceedings of the National Academy of Sciences, 120(6), 1-11. Article e2216836120. https://doi.org/10.1073/pnas.2216836120
Zazuli, Z., Op 't Hoog, C. J. P., Vijverberg, S. J. H., Masereeuw, R., Rassekh, S. R., Medeiros, M., Rivas-Ruiz, R., Maitland-van der Zee, A. H., & Carleton, B. C. (2023). Cisplatin-induced nephrotoxicity in childhood cancer: comparison between two countries. Pediatric Nephrology, 38(2), 593-604. https://doi.org/10.1007/s00467-022-05632-z
https://dspace.library.uu.nl/bitstream/handle/1874/426080/s00467_022_05632_z.pdf?sequence=1

2022

Scholarly publications

Soares Lindoso, R., Yousef Yengej, F. A., Völlmy, F., Altelaar, M., Juncosa, E. M., Tsikari, T., Ammerlaan, C. M. E., van Balkom, B., Rookmaaker, M. B., Verhaar, M. C., & Masereeuw, R. (2022). Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids. Journal of Nanobiotechnology, 20(1), 1-15. Article 326. https://doi.org/10.1186/s12951-022-01506-6
Jochems, P. G. M., Heming, B., Lapin, D., Moonen, N. E. L., Van den Ackerveken, G., & Masereeuw, R. (2022). Bioengineered intestinal tubules as a tool to test intestinal biological efficacy of lettuce species. npj Science of Food, 6(1), 1-8. Article 58. https://doi.org/10.1038/s41538-022-00175-x
Slingerland, C. J., Wesseling, C. M. J., Innocenti, P., Westphal, K. G. C., Masereeuw, R., & Martin, N. I. (2022). Synthesis and Evaluation of Polymyxins Bearing Reductively Labile Disulfide-Linked Lipids. Journal of Medicinal Chemistry, 65(23), 15878–15892. https://doi.org/10.1021/acs.jmedchem.2c01528
Wang, Z., Faria, J., van der Laan, L. J. W., Penning, L. C., Masereeuw, R., & Spee, B. (2022). Human Cholangiocytes Form a Polarized and Functional Bile Duct on Hollow Fiber Membranes. Frontiers in Bioengineering and Biotechnology, 10, 1-10. Article 868857. https://doi.org/10.3389/fbioe.2022.868857
Madella, A. M., Bergenhenegouwen, J. V., Garssen, J., Masereeuw, R., & Overbeek, S. A. (2022). Microbial-Derived Tryptophan Catabolites, Kidney Disease and Gut Inflammation. Toxins, 14(9), Article 645. https://doi.org/10.3390/toxins14090645
Favero, C., Giordano, L., Mihaila, S. M., Masereeuw, R., Ortiz, A., & Sanchez-Niño, M. D. (2022). Postbiotics and Kidney Disease. Toxins, 14(9), 1-17. Article 623. https://doi.org/10.3390/toxins14090623
Genderen, A. M. V., G Valverde, M., Capendale, P. E., Kersten, V., Sendino Garví, E., Schuurmans, C. C. L., Ruelas, M., Soeiro, J. T., Tang, G., Janssen, M. J., Jansen, J., Mihăilă, S. M., Vermonden, T., Zhang, Y. S., & Masereeuw, R. (2022). Co-axial Printing of Convoluted Proximal Tubule for Kidney Disease Modeling. Biofabrication, 14(4), 1-16. Article 044102. https://doi.org/10.1088/1758-5090/ac7895
Masereeuw, R. (2022). The Dual Roles of Protein-Bound Solutes as Toxins and Signaling Molecules in Uremia. Toxins, 14(6), Article 402. https://doi.org/10.3390/toxins14060402
Yang, Y., Mihajlovic, M., Valentijn, F., Nguyen, T. Q., Goldschmeding, R., & Masereeuw, R. (2022). A Human Conditionally Immortalized Proximal Tubule Epithelial Cell Line as a Novel Model for Studying Senescence and Response to Senolytics. Frontiers in Pharmacology, 13, 1-13. Article 791612. https://doi.org/10.3389/fphar.2022.791612
Evenepoel, P., Meijers, B., Masereeuw, R., & Lowenstein, J. (2022). Effects of an SGLT Inhibitor on the Production, Toxicity, and Elimination of Gut-Derived Uremic Toxins: A Call for Additional Evidence. Toxins, 14(3), Article 210. https://doi.org/10.3390/toxins14030210
García Valverde, M., Ferreira Faria, J., Sendino Garví, E., Janssen, M. J., Masereeuw, R., & Mihaila, S. (2022). Organs-on-chip technology: a tool to tackle genetic kidney diseases. Pediatric Nephrology, 37(12), 2985-2996. https://doi.org/10.1007/s00467-022-05508-2
Lindoso, R. S., Yengej, F. A. Y., Voellmy, F., Altelaar, M., Juncosa, E. M., Tsikari, T., Ammerlaan, C. M. E., Balkom, B. W. M. V., Verhaar, M. C., & Masereeuw, R. (2022). Differentiated kidney tubular cell-derived extracellular vesicles enhance maturation of tubuloids. (pp. 1-31). bioRxiv. https://doi.org/10.1101/2022.02.08.479621
https://dspace.library.uu.nl/bitstream/handle/1874/420003/2022.02.08.479621v1.full.pdf?sequence=1
Mihajlovic, M., Rikkers, M., Mihajlovic, M., Viola, M., Schuiringa, G., Ilochonwu, B. C., Masereeuw, R., Vonk, L., Malda, J., Ito, K., & Vermonden, T. (2022). Viscoelastic Chondroitin Sulfate and Hyaluronic Acid Double-Network Hydrogels with Reversible Cross-Links. Biomacromolecules, 23(3), 1350-1365. https://doi.org/10.1021/acs.biomac.1c01583
Valverde, M. G., Mille, L. S., Figler, K. P., Cervantes, E., Li, V. Y., Bonventre, J. V., Masereeuw, R., & Zhang, Y. S. (2022). Biomimetic models of the glomerulus. Nature Reviews Nephrology, 18(4), 241-257. https://doi.org/10.1038/s41581-021-00528-x
Clerbaux, L.-A., Amigó, N., Amorim, M. J., Bal-Price, A., Batista Leite, S., Beronius, A., Bostroem, A.-C., Carusi, A., Coecke, S., Concha, R., Daskalopoulos, E. P., Debernardi, F., Edrosa, E., Edwards, S. W., Filipovska, J., Garcia-Reyero, N., Gavins, F. N. E., Halappanavar, S., Hargreaves, A. J., ... Wittwehr, C. (2022). COVID-19 through Adverse Outcome Pathways: Building networks to better understand the disease - 3rd CIAO AOP Design Workshop. Altex, 39(2), 322–335. https://doi.org/10.14573/altex.2112161
Garví, E. S., Masereeuw, R., & Janssen, M. J. (2022). Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype. Cells, 11(1), 1-18. Article 177. https://doi.org/10.3390/cells11010177
Ahmed, S., Sparidans, R. W., Lu, J., Mihaila, S. M., Gerritsen, K. G. F., & Masereeuw, R. (2022). A robust, accurate, sensitive LC-MS/MS method to measure indoxyl sulfate, validated for plasma and kidney cells. Biomedical Chromatography, 36(5), 1-10. Article e5307. https://doi.org/10.1002/bmc.5307
Amirabadi, H. E., Donkers, J. M., Wierenga, E., Ingenhut, B., Pieters, L., Stevens, L., Donkers, T., Westerhout, J., Masereeuw, R., Bobeldijk-Pastorova, I., Nooijen, I., & Steeg, E. V. D. (2022). Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants. Lab on a Chip, 2022(2), 326-342. https://doi.org/10.1039/d1lc00669j
Pou Casellas, C., Jansen, K., Rookmaaker, M. B., Clevers, H., Verhaar, M. C., & Masereeuw, R. (2022). Regulation of Solute Carriers OCT2 and OAT1/3 in the Kidney: A Phylogenetic, Ontogenetic and Cell Dynamic Perspective. Physiological Reviews, 102(2), 993-1024. https://doi.org/10.1152/physrev.00009.2021

2021

Scholarly publications

van Berlo, D., & Masereeuw, R. (2021). Editorial overview: Disrupting the animal test with in vitro innovations. Current Opinion in Toxicology , 28, 49-51. https://doi.org/10.1016/j.cotox.2021.09.005
Taranta, A., elmonem, M. A., Bellomo, F., Leo, E. D., Boenzi, S., Janssen, M. J., Jamalpoor, A., Cairoli, S., Pastore, A., Stefanis, C. D., Colucci, M., Rega, L. R., giovannoni, I., Francalanci, P., Heuvel, L. P. V. D., Dionisi-Vici, C., Goffredo, B. M., Masereeuw, R., Levtchenko, E., & Emma, F. (2021). Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis. Cells, 10(12), 1-16. Article 3294. https://doi.org/10.3390/cells10123294
Zazuli, Z., Jong, C. D. D., Xu, W., Vijverberg, S. J. H., Masereeuw, R., Patel, D., Mirshams, M., Khan, K., Cheng, D., Ordonez-Perez, B., Huang, S. H., Spreafico, A., Hansen, A. R., Goldstein, D. P., Almeida, J. R. D. D., Bratman, S. V., Hope, A., Knox, J. J., Wong, R. K. S., ... Liu, G. (2021). Association between Genetic Variants and Cisplatin-Induced Nephrotoxicity: A Genome-Wide Approach and Validation Study. Journal of Personalized Medicine, 11(11), 1-19. Article 1233. https://doi.org/10.3390/jpm11111233
https://dspace.library.uu.nl/bitstream/handle/1874/413633/jpm_11_01233_v3.pdf?sequence=1
Mihajlovic, M., Krebber, M. M., Yang, Y., Ahmed, S., Lozovanu, V., Andreeva, D., Verhaar, M. C., & Masereeuw, R. (2021). Protein-Bound Uremic Toxins Induce Reactive Oxygen Species-Dependent and Inflammasome-Mediated IL-1β Production in Kidney Proximal Tubule Cells. Biomedicines, 9(10), 1-24. Article 1326. https://doi.org/10.3390/biomedicines9101326
King, J., Swapnasrita, S., Truckenmüller, R., Giselbrecht, S., Masereeuw, R., & Carlier, A. (2021). Modeling Indoxyl Sulfate Transport in a Bioartificial Kidney: Two-Step Binding Kinetics or Lumped Parameters Model for Uremic Toxin Clearance? Computers in Biology and Medicine, 138, 1-9. Article 104912. https://doi.org/10.1016/j.compbiomed.2021.104912
King, J., Mihaila, S. M., Ahmed, S., Truckenmüller, R., Giselbrecht, S., Masereeuw, R., & Carlier, A. (2021). The Influence of OAT1 Density and Functionality on Indoxyl Sulfate Transport in the Human Proximal Tubule: An Integrated Computational and In Vitro Study. Toxins, 13(10), 1-19. Article 674. https://doi.org/10.3390/toxins13100674
Vermue, IJ. M., Begum, R., Castilho, M., Rookmaaker, M. B., Masereeuw, R., Bouten, C. V. C., Verhaar, M. C., & Cheng, C. (2021). Renal Biology Driven Macro- and Microscale Design Strategies for Creating an Artificial Proximal Tubule Using Fiber-Based Technologies. ACS Biomaterials Science & Engineering, 7(10), 4679-4693. https://doi.org/10.1021/acsbiomaterials.1c00408
Groesen, E. V., Slingerland, C. J., Innocenti, P., Mihajlovic, M., Masereeuw, R., & Martin, N. I. (2021). Vancomyxins: Vancomycin-Polymyxin Nonapeptide Conjugates That Retain Anti-Gram-Positive Activity with Enhanced Potency against Gram-Negative Strains. ACS Infectious Diseases , 7(9), 2746-2754. https://doi.org/10.1021/acsinfecdis.1c00318
Irvine, A. R., van Berlo, D., Shekhani, R., & Masereeuw, R. (2021). A systematic review of in vitro models of drug-induced kidney injury. Current Opinion in Toxicology , 27, 18-26. https://doi.org/10.1016/j.cotox.2021.06.001
Faria, J., Gerritsen, K. G. F., Nguyen, T. Q., Mihaila, S. M., & Masereeuw, R. (2021). Diabetic proximal tubulopathy: Can we mimic the disease for in vitro screening of SGLT inhibitors? European Journal of Pharmacology, 908, 1-11. Article 174378. https://doi.org/10.1016/j.ejphar.2021.174378
Vinken, M., Benfenati, E., Busquet, F., Castell, J., Clevert, D.-A., de Kok, T., Dirven, H., Fritsche, E., Geris, L., Gozalbes, R., Hartung, T., Jennen, D., Jover, R., Kandarova, H., Kramer, N., Krul, C., Luechtefeld, T., Masereeuw, R., Roggen, E., ... Piersma, A. H. (2021). Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology, 458, 1-7. Article 152846. https://doi.org/10.1016/j.tox.2021.152846
https://dspace.library.uu.nl/bitstream/handle/1874/412525/1_s2.0_S0300483X21001694_main.pdf?sequence=1
van Berlo, D., van de Steeg, E., Amirabadi, H. E., & Masereeuw, R. (2021). The potential of multi-organ-on-chip models for assessment of drug disposition as alternative to animal testing. Current Opinion in Toxicology, 27, 8-17. https://doi.org/10.1016/j.cotox.2021.05.001
Jamalpoor, A., van Gelder, C. A. G. H., Yousef Yengej, F. A., Zaal, E. A., Berlingerio, S. P., Veys, K. R., Pou Casellas, C., Voskuil, K., Essa, K., Ammerlaan, C. M. E., Rega, L. R., van der Welle, R. E. N., Lilien, M. R., Rookmaaker, M. B., Clevers, H., Klumperman, J., Levtchenko, E., Berkers, C. R., Verhaar, M. C., ... Janssen, M. J. (2021). Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis. EMBO Molecular Medicine, 13(7), 1-20. Article e13067. https://doi.org/10.15252/emmm.202013067
Corrêa, R. R., Juncosa, E. M., Masereeuw, R., & Lindoso, R. S. (2021). Extracellular Vesicles as a Therapeutic Tool for Kidney Disease: Current Advances and Perspectives. International Journal of Molecular Sciences, 22(11), Article 5787. https://doi.org/10.3390/ijms22115787
Jamalpoor, A., Othman, A., Levtchenko, E. N., Masereeuw, R., & Janssen, M. J. (2021). Molecular Mechanisms and Treatment Options of Nephropathic Cystinosis. Trends in Molecular Medicine, 27(7), 673-686. https://doi.org/10.1016/j.molmed.2021.04.004
Vriend, J., Vormann, M. K., Lanz, H. L., Joore, J., Trietsch, S. J., Russel, F. G. M., Jacobsen, B., Roth, A., Lu, S., Polli, J. W., Naidoo, A. A., Masereeuw, R., Wilmer, M. J., & Suter-Dick, L. (2021). Nephroscreen: A robust and versatile renal tubule-on-a-chip platform for nephrotoxicity assessment. Current Opinion in Toxicology, 25, 42-48. https://doi.org/10.1016/j.cotox.2021.03.001
Vlahou, A., Hallinan, D., Apweiler, R., Argiles, A., Beige, J., Benigni, A., Bischoff, R., Black, P. C., Boehm, F., Céraline, J., Chrousos, G. P., Delles, C., Evenepoel, P., Fridolin, I., Glorieux, G., van Gool, A. J., Heidegger, I., Ioannidis, J. P. A., Jankowski, J., ... Vanholder, R. (2021). Data Sharing Under the General Data Protection Regulation: Time to Harmonize Law and Research Ethics? Hypertension (Dallas, Tex. : 1979), 77(4), 1029-1035. https://doi.org/10.1161/HYPERTENSIONAHA.120.16340
Vormann, M. K., Vriend, J., Lanz, H. L., Gijzen, L., van den Heuvel, A., Hutter, S., Joore, J., Trietsch, S. J., Stuut, C., Nieskens, T. T. G., Peters, J. G. P., Ramp, D., Caj, M., Russel, F. G. M., Jacobsen, B., Roth, A., Lu, S., Polli, J. W., Naidoo, A. A., ... Suter-Dick, L. (2021). Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies. Journal of Pharmaceutical Sciences, 110(4), 1601-1614. https://doi.org/10.1016/j.xphs.2021.01.028
van Genderen, A. M., Jansen, K., Kristen, M., van Duijn, J. H., Li, Y., Schuurmans, C. C. L., Malda, J., Vermonden, T., Jansen, J., Masereeuw, R., & Castilho, M. (2021). Topographic Guidance in Melt-Electrowritten Tubular Scaffolds Enhances Engineered Kidney Tubule Performance. Frontiers in Bioengineering and Biotechnology, 8, 1-14. Article 617364. https://doi.org/10.3389/fbioe.2020.617364
Jansen, K., Evangelopoulou, M., Pou Casellas, C., Abrishamcar, S., Jansen, J., Vermonden, T., & Masereeuw, R. (2021). Spinach and Chive for Kidney Tubule Engineering: the Limitations of Decellularized Plant Scaffolds and Vasculature. AAPS Journal, 23(1), 1-7. Article 11. https://doi.org/10.1208/s12248-020-00550-0
Giordano, L., Mihaila, S. M., Eslami Amirabadi, H., & Masereeuw, R. (2021). Microphysiological Systems to Recapitulate the Gut–Kidney Axis. Trends in Biotechnology, 39(8), 811-823. https://doi.org/10.1016/j.tibtech.2020.12.001
Wang, Z., Faria, J., Penning, L., Masereeuw, R., & Spee, B. (2021). Tissue Engineered Bile Ducts for Disease Modeling and Therapy. Tissue engineering. Part C, Methods, 27(2), 59-76. https://doi.org/10.1089/ten.TEC.2020.0283
Rood, J. J. M., Jamalpoor, A., van Hoppe, S., van Haren, M. J., Wasmann, R. E., Janssen, M. J., Schinkel, A. H., Masereeuw, R., Beijnen, J. H., & Sparidans, R. W. (2021). Extrahepatic metabolism of ibrutinib. Investigational New Drugs, 39(1), 1-14. https://doi.org/10.1007/s10637-020-00970-x

2020

Scholarly publications

Jamalpoor, A., van Gelder, C. A. G. H., Yousef Yengej, F. A., Zaal, E. A., Berlingerio, S. P., Veys, K. R., Pou Casellas, C., Voskuil, K., Essa, K., Ammerlaan, C., Rega, L. R., van der Welle, R., Lilien, M. R., Rookmaaker, M. B., Clevers, H. C., Klumperman, J., Levtchenko, E., Berkers, C. R., Verhaar, M. C., ... Janssen, M. J. (2020). Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis. (pp. 1-53). bioRxiv. https://doi.org/10.1101/2020.02.10.941799
Bajaj, P., Masereeuw, R., & McDuffie, J. E. (2020). Predictive and translational models for renal drug safety evaluation. In Identification and quantification of drugs, metabolites, drug metabolizing enzymes, and transporters: Concepts, Methods, and Translational Sciences (2 ed., pp. 507-534). Elsevier Science. https://doi.org/10.1016/B978-0-12-820018-6.00018-1
Jochems, P. G. M., Keusters, W. R., America, A. H. P., Rietveld, P. C. S., Bastiaan-Net, S., Ariëns, R. M. C., Tomassen, M. M. M., Lewis, F., Li, Y., Westphal, K. G. C., Garssen, J., Wichers, H. J., van Bergenhenegouwen, J., & Masereeuw, R. (2020). A combined microphysiological-computational omics approach in dietary protein evaluation. npj Science of Food, 4(1), Article 22. https://doi.org/10.1038/s41538-020-00082-z
Zazuli, Z., Duin, N. J. C. B., Jansen, K., Vijverberg, S. J. H., Maitland-van der Zee, A. H., & Masereeuw, R. (2020). The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition. International Journal of Molecular Sciences, 21(18), Article 6627. https://doi.org/10.3390/ijms21186627
Bauer, B., Renfro, J. L., Karnaky, K. J., Masereeuw, R., Fricker, G., Cannon, R. E., & Hartz, A. M. S. (2020). David S. Miller: Scientist, Mentor, Friend-a tribute and thank you. Fluids and Barriers of the CNS, 17(1), Article 56. https://doi.org/10.1186/s12987-020-00220-5
Jochems, P. G. M., Garssen, J., Rietveld, P. C. S., Govers, C., Tomassen, M. M. M., Wichers, H. J., van Bergenhenegouwen, J., & Masereeuw, R. (2020). Novel Dietary Proteins Selectively Affect Intestinal Health In Vitro after Clostridium difficile-Secreted Toxin A Exposure. Nutrients, 12(9), Article 2782. https://doi.org/10.3390/nu12092782
Langerak, N., Ahmed, H. M. M., Li, Y., Middel, I. R., Eslami Amirabadi, H., Malda, J., Masereeuw, R., & van Roij, R. (2020). A Theoretical and Experimental Study to Optimize Cell Differentiation in a Novel Intestinal Chip. Frontiers in Bioengineering and Biotechnology, 8, Article 763. https://doi.org/10.3389/fbioe.2020.00763
Zazuli, Z., Kos, R., Veltman, J. D., Uyterlinde, W., Longo, C., Baas, P., Masereeuw, R., Vijverberg, S. J. H., & Maitland-van der Zee, A. H. (2020). Comparison of Myelotoxicity and Nephrotoxicity Between Daily Low-Dose Cisplatin With Concurrent Radiation and Cyclic High-Dose Cisplatin in Non-Small Cell Lung Cancer Patients. Frontiers in Pharmacology, 11, Article 975. https://doi.org/10.3389/fphar.2020.00975
Mihaila, S. M., Faria, J., Stefens, M. F. J., Stamatialis, D., Verhaar, M. C., Gerritsen, K. G. F., & Masereeuw, R. (2020). Drugs commonly applied to kidney patients may compromise renal tubular uremic toxins excretion. Toxins, 12(6), Article 391. https://doi.org/10.3390/toxins12060391
De Leo, E., Elmonem, M. A., Berlingerio, S. P., Berquez, M., Festa, B. P., Raso, R., Bellomo, F., Starborg, T., Janssen, M. J., Abbaszadeh, Z., Cairoli, S., Goffredo, B. M., Masereeuw, R., Devuyst, O., Lowe, M., Levtchenko, E., Luciani, A., Emma, F., & Rega, L. R. (2020). Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. Journal of the American Society of Nephrology : JASN, 31(7), 1522-1537. https://doi.org/10.1681/ASN.2019090956
Punt, A., Bouwmeester, H., Blaauboer, B. J., Coecke, S., Hakkert, B., Hendriks, D. F. G., Jennings, P., Kramer, N. I., Neuhoff, S., Masereeuw, R., Paini, A., Peijnenburg, A. A. C. M., Rooseboom, M., Shuler, M. L., Sorrell, I., Spee, B., Strikwold, M., Van der Meer, A. D., Van der Zande, M., ... Heringa, M. B. (2020). New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment. Altex, 37(4), 607-622. https://doi.org/10.14573/altex.2003242
Masereeuw, R., & Verhaar, M. C. (2020). Innovations in approaches to remove uraemic toxins. Nature Reviews. Nephrology, 16, 552–553. https://doi.org/10.1038/s41581-020-0299-0
https://dspace.library.uu.nl/bitstream/handle/1874/432336/s41581-020-0299-0.pdf?sequence=1
van Gelder, M. K., Middel, I. R., Vernooij, R. W. M., Bots, M. L., Verhaar, M. C., Masereeuw, R., Grooteman, M. P., Nubé, M. J., van den Dorpel, M. A., Blankestijn, P. J., Rookmaaker, M. B., & Gerritsen, K. G. F. (2020). Protein-Bound Uremic Toxins in Hemodialysis Patients Relate to Residual Kidney Function, Are Not Influenced by Convective Transport, and Do Not Relate to Outcome. Toxins, 12(4), Article 234. https://doi.org/10.3390/toxins12040234
Sun, Y., Goes Martini, A., Janssen, M. J., Garrelds, I. M., Masereeuw, R., Lu, X., & Danser, A. H. J. (2020). Megalin: A Novel Endocytic Receptor for Prorenin and Renin. Hypertension (Dallas, Tex. : 1979), 75(5), 1242-1250. https://doi.org/10.1161/HYPERTENSIONAHA.120.14845
Gong, J., Schuurmans, C. C. L., Genderen, A. M. V., Cao, X., Li, W., Cheng, F., He, J. J., López, A., Huerta, V., Manríquez, J., Li, R., Li, H., Delavaux, C., Sebastian, S., Capendale, P. E., Wang, H., Xie, J., Yu, M., Masereeuw, R., ... Zhang, Y. S. (2020). Complexation-induced resolution enhancement of 3D-printed hydrogel constructs. Nature Communications, 11(1), Article 1267. https://doi.org/10.1038/s41467-020-14997-4
Bovée, D. M., Visser, W. J., Middel, I., De Mik-van Egmond, A., Greupink, R., Masereeuw, R., Russel, F. G. M., Danser, A. H. J., Zietse, R., & Hoorn, E. J. (2020). A Randomized Trial of Distal Diuretics versus Dietary Sodium Restriction for Hypertension in Chronic Kidney Disease. Journal of the American Society of Nephrology : JASN, 31(3), 650-662. https://doi.org/10.1681/ASN.2019090905
Jansen, K., Pou Casellas, C., Groenink, L., Wever, K. E., & Masereeuw, R. (2020). Humans are animals, but are animals human enough? A systematic review and meta-analysis on interspecies differences in renal drug clearance. Drug Discovery Today, 25(4), 706-717. https://doi.org/10.1016/j.drudis.2020.01.018
Vriend, J., Peters, J. G. P., Nieskens, T. T. G., Škovroňová, R., Blaimschein, N., Schmidts, M., Roepman, R., Schirris, T. J. J., Russel, F. G. M., Masereeuw, R., & Wilmer, M. J. (2020). Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia. Biochimica et Biophysica Acta - General Subjects, 1864(1), Article 129433. https://doi.org/10.1016/j.bbagen.2019.129433
Sánchez-Romero, N., Martínez-Gimeno, L., Caetano-Pinto, P., Saez, B., Sánchez-Zalabardo, J. M., Masereeuw, R., & Giménez, I. (2020). A simple method for the isolation and detailed characterization of primary human proximal tubule cells for renal replacement therapy. International Journal of Artificial Organs, 43(1), 45-57. https://doi.org/10.1177/0391398819866458

2019

Scholarly publications

Louzao-Martinez, L., van Dijk, C. G. M., Juan Xu, Y., Korn, A., Bekker, N., Brouwhuis, R., Nicese, M. N., Demmers, J. A. A., Goumans, M.-J. T. H., Masereeuw, R., Duncker, D. J., Verhaar, M. C., & Cheng, C. (2019). A proteome comparison between human fetal and mature renal extracellular matrix identifies EMILIN1 as a regulator of renal epithelial cell adhesion. Matrix Biology, 4, Article 100011. https://doi.org/10.1016/j.mbplus.2019.100011
Faria, J., Ahmed, S., Gerritsen, K. G. F., Mihaila, S. M., & Masereeuw, R. (2019). Kidney-based in vitro models for drug-induced toxicity testing. Archives of Toxicology, 93, 3397–3418. https://doi.org/10.1007/s00204-019-02598-0
Abyar, S., Khandar, A. A., Salehi, R., Abolfazl Hosseini-Yazdi, S., Alizadeh, E., Mahkam, M., Jamalpoor, A., White, J. M., Shojaei, M., Aizpurua-Olaizola, O., Masereeuw, R., & Janssen, M. J. (2019). In vitro nephrotoxicity and anticancer potency of newly synthesized cadmium complexes. Scientific Reports, 9, Article 14686. https://doi.org/10.1038/s41598-019-51109-9
Janssen, M. J., Nieskens, T. T. G., Steevels, T. A. M., Caetano-Pinto, P., den Braanker, D., Mulder, M., Ponstein, Y., Jones, S., Masereeuw, R., den Besten, C., & Wilmer, M. J. (2019). Therapy with 2'-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption. Molecular Therapy - Nucleic Acids, 18, 298-307. https://doi.org/10.1016/j.omtn.2019.08.025
Mihajlovic, M., Hariri, S., Westphal, K. C. G., Janssen, M. J., Oost, M. J., Bongiovanni, L., Van Den Heuvel, L. P., De Bruin, A., Hilbrands, L. B., & Masereeuw, R. (2019). Safety evaluation of conditionally immortalized cells for renal replacement therapy. Oncotarget, 10(51), 5332-5348. https://doi.org/10.18632/oncotarget.27152
Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Sastre Torano, J., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B., & Masereeuw, R. (2019). Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proceedings of the National Academy of Sciences of the United States of America, 116(32), 16105-16110. https://doi.org/10.1073/pnas.1821809116
Deltombe, O., Glorieux, G., Marzouki, S., Masereeuw, R., Schneditz, D., & Eloot, S. (2019). Selective Transport of Protein-Bound Uremic Toxins in Erythrocytes. Toxins, 11(7), Article 385. https://doi.org/10.3390/toxins11070385
Zazuli, Z., Otten, L. S., Drögemöller, B. I., Medeiros, M., Monzon, J. G., Wright, G. E. B., Kollmannsberger, C. K., Bedard, P. L., Chen, Z., Gelmon, K. A., McGoldrick, N., Kitchlu, A., Vijverberg, S. J. H., Masereeuw, R., Ross, C. J. D., Liu, G., Carleton, B. C., & Maitland-van der Zee, A. H. (2019). Outcome Definition Influences the Relationship Between Genetic Polymorphisms of ERCC1, ERCC2, SLC22A2 and Cisplatin Nephrotoxicity in Adult Testicular Cancer Patients. Genes, 10(5), Article 364. https://doi.org/10.3390/genes10050364
Jochems, P. G. M., van Bergenhenegouwen, J., van Genderen, A. M., Eis, S. T., Wilod Versprille, L. J. F., Wichers, H. J., Jeurink, P. V., Garssen, J., & Masereeuw, R. (2019). Development and validation of bioengineered intestinal tubules for translational research aimed at safety and efficacy testing of drugs and nutrients. Toxicology in Vitro, 60, 1-11. https://doi.org/10.1016/j.tiv.2019.04.019
on behalf of the European Uremic Toxin Work Group-EUTox (2019). Serum levels of miR-126 and miR-223 and outcomes in chronic kidney disease patients. Scientific Reports, 9(1), Article 4477. https://doi.org/10.1038/s41598-019-41101-8
Schutgens, F., Rookmaaker, M. B., Margaritis, T., Rios, A., Ammerlaan, C., Jansen, J., Gijzen, L., Vormann, M., Vonk, A., Viveen, M., Yengej, F. Y., Derakhshan, S., de Winter-de Groot, K. M., Artegiani, B., van Boxtel, R., Cuppen, E., Hendrickx, A. P. A., van den Heuvel-Eibrink, M. M., Heitzer, E., ... Clevers, H. (2019). Tubuloids derived from human adult kidney and urine for personalized disease modeling. Nature Biotechnology, 37(3), 303-313. https://doi.org/10.1038/s41587-019-0048-8
https://dspace.library.uu.nl/bitstream/handle/1874/378205/Tubuloids.pdf?sequence=1
Mihajlovic, M., Wever, K. E., van der Made, T. K., de Vries, R. B. M., Hilbrands, L. B., & Masereeuw, R. (2019). Are cell-based therapies for kidney disease safe? A systematic review of preclinical evidence. Pharmacology and Therapeutics, 197, 191-211. https://doi.org/10.1016/j.pharmthera.2019.01.004
Vriend, J., Hoogstraten, C. A., Venrooij, K. R., Berge, B. T. V. D., Govers, L. P., Rooij, A. V., Huigen, M. C. D. G., Schirris, T. J. J., Russel, F. G. M., Masereeuw, R., & Wilmer, M. J. (2019). Organic anion transporter 1 and 3 influence cellular energy metabolism in renal proximal tubule cells. Biological Chemistry, 400(10), 1347–1358. https://doi.org/10.1515/hsz-2018-0446
Jansen, K., Castilho, M., Aarts, S., Kaminski, M. M., Lienkamp, S. S., Pichler, R., Malda, J., Vermonden, T., Jansen, J., & Masereeuw, R. (2019). Fabrication of Kidney Proximal Tubule Grafts Using Biofunctionalized Electrospun Polymer Scaffolds. Macromolecular Bioscience, 19(2), Article e1800412. https://doi.org/10.1002/mabi.201800412
van Gaal, R. C., Fedecostante, M., Fransen, P.-P. K. H., Masereeuw, R., & Dankers, P. Y. W. (2019). Renal Epithelial Monolayer Formation on Monomeric and Polymeric Catechol Functionalized Supramolecular Biomaterials. Macromolecular Bioscience, 19(2), Article e1800300. https://doi.org/10.1002/mabi.201800300
Groth, C., van Groningen, L. F. J., Matos, T. R., Bremmers, M. E., Preijers, F. W. M. B., Dolstra, H., Reicherts, C., Schaap, N. P. M., van Hooren, E. H. G., IntHout, J., Netea, M. G., Masereeuw, R., Levine, J. E., Morales, G., Ferrara, J. L., Blijlevens, N. M. A., van Oosterhout, Y. V. J. M., Stelljes, M., & van der Velden, W. J. F. M. (2019). Phase I/II trial of a combination of anti-CD3/CD7 immunotoxins for steroid-refractory acute graft-versus-host disease. Biology of Blood and Marrow Transplantation, 25(4), 712-719. https://doi.org/10.1016/j.bbmt.2018.10.020
https://dspace.library.uu.nl/bitstream/handle/1874/391643/1_s2.0_S1083879118306918_main.pdf?sequence=1
Mihajlovic, M., Mihajlovic, M., Dankers, P. Y. W., Masereeuw, R., & Sijbesma, R. P. (2019). Carbon Nanotube Reinforced Supramolecular Hydrogels for Bioapplications. Macromolecular Bioscience, 19(1), Article e1800173. https://doi.org/10.1002/mabi.201800173

Professional publications

van der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-Hodjegan, A., Sastre Toraño, J., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R., & Galetin, A. (2019). Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease. Molecular Pharmaceutics, 16, 4551-4562. https://doi.org/10.1021/acs.molpharmaceut.9b00681
https://dspace.library.uu.nl/bitstream/handle/1874/386489/acs.molpharmaceut.9b00681.pdf?sequence=1

2018

Scholarly publications

Zazuli, Z., Vijverberg, S., Slob, E., Liu, G., Carleton, B., Veltman, J., Baas, P., Masereeuw, R., & Maitland-van der Zee, A.-H. (2018). Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review. Frontiers in Pharmacology, 9, Article 1111. https://doi.org/10.3389/fphar.2018.01111
Legallais, C., Kim, D., Mihaila, S. M., Mihajlovic, M., Figliuzzi, M., Bonandrini, B., Salerno, S., Yousef Yengej, F. A., Rookmaaker, M. B., Sanchez Romero, N., Sainz-Arnal, P., Pereira, U., Pasqua, M., Gerritsen, K. G. F., Verhaar, M. C., Remuzzi, A., Baptista, P. M., De Bartolo, L., Masereeuw, R., & Stamatialis, D. (2018). Bioengineering Organs for Blood Detoxification. Advanced healthcare materials, 7(21), Article e1800430. https://doi.org/10.1002/adhm.201800430
https://dspace.library.uu.nl/bitstream/handle/1874/374672/Bioengineering.pdf?sequence=1
Lai, R. E., & Masereeuw, R. (2018). Adding the T to ADME: Predictive Toxicity in Renal Drug Development. The AAPS journal, 20(6), Article 98. https://doi.org/10.1208/s12248-018-0258-x
Vormann, M. K., Gijzen, L., Hutter, S., Boot, L., Nicolas, A., van den Heuvel, A., Vriend, J., Ng, C. P., Nieskens, T. T. G., van Duinen, V., de Wagenaar, B., Masereeuw, R., Suter-Dick, L., Trietsch, S. J., Wilmer, M., Joore, J., Vulto, P., & Lanz, H. L. (2018). Nephrotoxicity and Kidney Transport Assessment on 3D Perfused Proximal Tubules. The AAPS journal, 20(5), Article 90. https://doi.org/10.1208/s12248-018-0248-z
van Genderen, A. M., Jansen, J., Cheng, C., Vermonden, T., & Masereeuw, R. (2018). Renal Tubular- and Vascular Basement Membranes and their Mimicry in Engineering Vascularized Kidney Tubules. Advanced healthcare materials, 7(19), Article e1800529. https://doi.org/10.1002/adhm.201800529
Suter-Dick, L., Mauch, L., Ramp, D., Caj, M., Vormann, M. K., Hutter, S., Lanz, H. L., Vriend, J., Masereeuw, R., & Wilmer, M. J. (2018). Combining Extracellular miRNA Determination with Microfluidic 3D Cell Cultures for the Assessment of Nephrotoxicity: a Proof of Concept Study. The AAPS journal, 20(5), Article 86. https://doi.org/10.1208/s12248-018-0245-2
Vriend, J., Nieskens, T. T. G., Vormann, M. K., van den Berge, B. T., van den Heuvel, A., Russel, F. G. M., Suter-Dick, L., Lanz, H. L., Vulto, P., Masereeuw, R., & Wilmer, M. J. (2018). Screening of Drug-Transporter Interactions in a 3D Microfluidic Renal Proximal Tubule on a Chip. The AAPS journal, 20(5), Article 87. https://doi.org/10.1208/s12248-018-0247-0
Schuurmans, C. C. L., Abbadessa, A., Bengtson, M. A., Pletikapic, G., Eral, H. B., Koenderink, G., Masereeuw, R., Hennink, W. E., & Vermonden, T. (2018). Complex coacervation-based loading and tunable release of a cationic protein from monodisperse glycosaminoglycan microgels. Soft Matter, 14(30), 6327-6341. https://doi.org/10.1039/c8sm00686e
Fedecostante, M., Westphal, K., Buono, M., Sanchez Romero, N., Wilmer, M. J., Kerkering, J., Baptista, P. M., Hoenderop, J. G., & Masereeuw, R. (2018). Recellularized native kidney scaffolds as a novel tool in nephrotoxicity screening. Drug Metabolism and Disposition, 46(9), 1338-1350. https://doi.org/10.1124/dmd.118.080721
https://dspace.library.uu.nl/bitstream/handle/1874/368269/1338.full.pdf?sequence=1
van Raaij, S. E. G., Masereeuw, R., Swinkels, D. W., & van Swelm, R. P. L. (2018). Inhibition of Nrf2 alters cell stress induced by chronic iron exposure in human proximal tubular epithelial cells. Toxicology Letters, 295, 179-186. https://doi.org/10.1016/j.toxlet.2018.06.1218
Chen, C., Jochems, P., Salz, L., Schneeberger, K., Penning, L. C., van de Graaf, S. F. J., Beuers, U., Clevers, H., Geijsen, N., Masereeuw, R., & Spee, B. (2018). Bioengineered bile ducts recapitulate key cholangiocyte functions. Biofabrication, 10(3), Article 034103. https://doi.org/10.1088/1758-5090/aac8fd
https://dspace.library.uu.nl/bitstream/handle/1874/369772/Chen_2018_Biofabrication_10_034103.pdf?sequence=1
van Gelder, M. K., Mihaila, S. M., Jansen, J., Wester, M., Verhaar, M. C., Joles, J. A., Stamatialis, D., Masereeuw, R., & Gerritsen, K. G. F. (2018). From portable dialysis to a bioengineered kidney. Expert Review of Medical Devices, 15(5), 323-336. https://doi.org/10.1080/17434440.2018.1462697
Chevtchik, N. V., Mihajlovic, M., Fedecostante, M., Bolhuis-Versteeg, L., Sastre Toraño, J., Masereeuw, R., & Stamatialis, D. (2018). A bioartificial kidney device with polarized secretion of immune modulators. Journal of Tissue Engineering and Regenerative Medicine, 12(7), 1670–1678. https://doi.org/10.1002/term.2694
https://dspace.library.uu.nl/bitstream/handle/1874/369770/Chevtchik_et_al_2018_Journal_of_Tissue_Engineering_and_Regenerative_Medicine.pdf?sequence=1
Soo, J. Y.-C., Jansen, J., Masereeuw, R., & Little, M. H. (2018). Advances in predictive in vitro models of drug-induced nephrotoxicity. Nature Reviews Nephrology, 14(6), 378-393. https://doi.org/10.1038/s41581-018-0003-9
Jochems, P. G. M., Garssen, J., van Keulen, A. M., Masereeuw, R., & Jeurink, P. V. (2018). Evaluating Human Intestinal Cell Lines for Studying Dietary Protein Absorption. Nutrients, 10(3), Article 322. https://doi.org/10.3390/nu10030322
Nieskens, T. TG., Peters, J. GP., Dabaghie, D., Korte, D., Jansen, K., van Asbeck, A. H., Tavraz, N. N., Friedrich, T., Russel, F. G., Masereeuw, R., & Wilmer, M. J. (2018). Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity. Drug Metabolism and Disposition, 46(5), 592-599. https://doi.org/10.1124/dmd.117.079384
Jamalpoor, A., Sparidans, R. W., Casellas, C. P., Rood, J. J. M., Joshi, M., Masereeuw, R., & Janssen, M. J. (2018). Quantification of cystine in human renal proximal tubule cells using liquid chromatography-tandem mass spectrometry. Biomedical Chromatography, 32(8), 1-7. Article e4238. https://doi.org/10.1002/bmc.4238
Santana Machado, T., Poitevin, S., Paul, P., McKay, N., Jourde-Chiche, N., Legris, T., Mouly-Bandini, A., Dignat-George, F., Brunet, P., Masereeuw, R., Burtey, S., & Cerini, C. (2018). Indoxyl Sulfate Upregulates Liver P-Glycoprotein Expression and Activity through Aryl Hydrocarbon Receptor Signaling. Journal of the American Society of Nephrology : JASN, 29(3), 906-918. https://doi.org/10.1681/ASN.2017030361
https://dspace.library.uu.nl/bitstream/handle/1874/363241/Indoxyl.pdf?sequence=1
Hulshof, F., Schophuizen, C., Mihajlovic, M., van Blitterswijk, C., Masereeuw, R., de Boer, J., & Stamatialis, D. (2018). New insights into the effects of biomaterial chemistry and topography on the morphology of kidney epithelial cells. Journal of Tissue Engineering and Regenerative Medicine, 12(2), e817-e827. https://doi.org/10.1002/term.2387

2017

Scholarly publications

Chevtchik, N. V., Caetano Pinto, P., Masereeuw, R., & Stamatialis, D. (2017). Membranes for bioartificial kidney devices. In D. Stamatialis (Ed.), Biomedical Membranes And (Bio)artificial Organs (pp. 105-147). (World scientific series in membrane science and technology; Vol. 2). World Scientific Publishing Co. Pte Ltd.
Mihajlovic, M., Fedecostante, M., Oost, M. J., Steenhuis, S. K. P., Lentjes, E. G. W. M., Maitimu-Smeele, I., Janssen, M. J., Hilbrands, L. B., & Masereeuw, R. (2017). Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions. International Journal of Molecular Sciences, 18(12), Article 2531. https://doi.org/10.3390/ijms18122531
Masereeuw, R., Vriend, J., & Wilmer, M. J. (2017). Kidney-on-a-Chip: Technologies for Studying Pharmacological and Therapeutic Approaches to Kidney Repair. In Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era (pp. 1119-1133). Elsevier. https://doi.org/10.1016/B978-0-12-801734-0.00082-5
Reda, A., Raaijmakers, A., van Dorst, S., Pauwels, C. G. G. M., Allegaert, K., Elmonem, M. A., Masereeuw, R., van den Heuvel, L. W. P. J., Levtchenko, E., & Arcolino, F. O. (2017). A Human Proximal Tubular Epithelial Cell Model to Explore a Knowledge Gap on Neonatal Drug Disposition. Current Pharmaceutical Design, 23(38), 5911 - 5918. https://doi.org/10.2174/1381612823666171009143146
Jansen, K., Schuurmans, C. C. L., Jansen, J., Masereeuw, R., & Vermonden, T. (2017). Hydrogel-based cell therapies for kidney regeneration: current trends in biofabrication and in vivo repair. Current Pharmaceutical Design, 23(26), 3845 - 3857. https://doi.org/10.2174/1381612823666170710155726
Mihajlovic, M., van den Heuvel, L. W. P. J., Hoenderop, J. G. J., Jansen, J., Wilmer, M. J., Westheim, A. J. F., Allebes, W. A., Stamatialis, D., Hilbrands, L. B., & Masereeuw, R. (2017). Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application. Scientific Reports, 7(1), Article 7103. https://doi.org/10.1038/s41598-017-07582-1
Schirris, T. J. J., Jansen, J., Mihajlovic, M., van den Heuvel, L. P., Masereeuw, R., & Russel, F. G. M. (2017). Mild intracellular acidification by dexamethasone attenuates mitochondrial dysfunction in a human inflammatory proximal tubule epithelial cell model. Scientific Reports, 7, Article 10623. https://doi.org/10.1038/s41598-017-10483-y
Jansen, J., Jankowski, J., Gajjala, P. R., Wetzels, J. F. M., & Masereeuw, R. (2017). Disposition and clinical implications of protein-bound uremic toxins. Clinical Science, 131(14), 1631-1647. https://doi.org/10.1042/CS20160191
Masereeuw, R., & Stamatialis, D. (2017). Creating a bioartificial kidney. International Journal of Artificial Organs, 40(7), 323-327. https://doi.org/10.5301/IJAO.5000581
Caetano-Pinto, P., Jamalpoor, A., Ham, J., Goumenou, A., Mommersteeg, M., Pijnenburg, D., Ruijtenbeek, R., Sánchez-Romero, N., van Zelst, B., Heil, S., Jansen, J., Wilmer, M. J., van Herpen, C. M. L., & Masereeuw, R. (2017). Cetuximab prevents methotrexate-induced cytotoxicity in vitro through epidermal growth factor dependent regulation of renal drug transporters. Molecular Pharmaceutics, 14(6), 2147-2157. https://doi.org/10.1021/acs.molpharmaceut.7b00308
Fedecostante, M., Onciu, O. G., Westphal, K. G. C., & Masereeuw, R. (2017). Towards a bioengineered kidney: recellularization strategies for decellularized native kidney scaffolds. International Journal of Artificial Organs, 40(4), 150-158. https://doi.org/10.5301/ijao.5000564
Maicas, N., van der Vlag, J., Bublitz, J., Florquin, S., Bakker-van Bebber, M., Dinarello, C. A., Verweij, V., Masereeuw, R., Joosten, L. A., & Hilbrands, L. B. (2017). Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction and acute tubular necrosis in a murine model of bilateral kidney ischemia-reperfusion injury. PLoS One, 12(2), Article e0168981. https://doi.org/10.1371/journal.pone.0168981
Caetano-Pinto, P., Jansen, J., Assaraf, Y. G., & Masereeuw, R. (2017). The importance of breast cancer resistance protein to the kidneys excretory function and chemotherapeutic resistance. Drug Resistance Updates, 30, 15-27. https://doi.org/10.1016/j.drup.2017.01.002
https://dspace.library.uu.nl/bitstream/handle/1874/348421/importance.pdf?sequence=1
Peters, E., Schirris, T., van Asbeck, A. H., Gerretsen, J., Eymael, J., Ashikov, A., Adjobo-Hermans, M. J. W., Russel, F., Pickkers, P., & Masereeuw, R. (2017). Effects of a human recombinant alkaline phosphatase during impaired mitochondrial function in human renal proximal tubule epithelial cells. European Journal of Pharmacology, 796, 149-157. https://doi.org/10.1016/j.ejphar.2016.12.034
https://dspace.library.uu.nl/bitstream/handle/1874/343728/Effects.pdf?sequence=1

2016

Scholarly publications

van den Brand, J. A. J. G., Mutsaers, H. A. M., van Zuilen, A. D., Blankestijn, P. J., van den Broek, P. H., Russel, F. G. M., Masereeuw, R., & Wetzels, J. F. M. (2016). Uremic Solutes in Chronic Kidney Disease and Their Role in Progression. PLoS One, 11(12), Article e0168117. https://doi.org/10.1371/journal.pone.0168117
Peters, E., Ergin, B., Kandil, A., Gurel-Gurevin, E., van Elsas, A., Masereeuw, R., Pickkers, P., & Ince, C. (2016). Effects of a human recombinant alkaline phosphatase on renal hemodynamics, oxygenation and inflammation in two models of acute kidney injury. Toxicology and Applied Pharmacology, 313, 88-96. https://doi.org/10.1016/j.taap.2016.10.015
https://dspace.library.uu.nl/bitstream/handle/1874/341357/Effects_of_a_human_recombinant_alkaline_phosphatase_on_renal_hemodynamics_oxygenation_and_inflammation_in_two_models_of_acute_kidney_injury.pdf?sequence=1
van Breda, G. F., Bongartz, L. G., Zhuang, W., van Swelm, R. P. L., Pertijs, J., Braam, B., Cramer, M.-J., Swinkels, D. W., Doevendans, P. A., Verhaar, M. C., Masereeuw, R., Joles, J. A., & Gaillard, C. A. J. M. (2016). Cardiac Hepcidin Expression Associates with Injury Independent of Iron. American Journal of Nephrology, 44(5), 368-378. https://doi.org/10.1159/000449419
https://dspace.library.uu.nl/bitstream/handle/1874/341356/Cardiac_Hepcidin_Expression_Associates.pdf?sequence=1
Huang, J., Weinfurter, S., Pinto, P. C., Pretze, M., Kränzlin, B., Pill, J., Federica, R., Perciaccante, R., Ciana, L. D., Masereeuw, R., & Gretz, N. (2016). Fluorescently labeled cyclodextrin derivatives as exogenous markers for real-time transcutaneous measurement of renal function. Bioconjugate Chemistry, 27(10), 2513-2526. https://doi.org/10.1021/acs.bioconjchem.6b00452
https://dspace.library.uu.nl/bitstream/handle/1874/342218/Fluorescently.pdf?sequence=1
Janssen, M. J., & Masereeuw, R. (2016). An introduction to the pharmacology of kidney regeneration. European Journal of Pharmacology, 790, 1-2. https://doi.org/10.1016/j.ejphar.2016.06.055
Sánchez-Romero, N., Schophuizen, C. M. S., Giménez, I., & Masereeuw, R. (2016). In vitro systems to study nephropharmacology: 2D versus 3D models. European Journal of Pharmacology, 1-10. https://doi.org/10.1016/j.ejphar.2016.07.010
https://dspace.library.uu.nl/bitstream/handle/1874/336982/1_s2.0_S001429991630440X_main.pdf?sequence=1
Chevtchik, N. V., Fedecostante, M., Jansen, J., Mihajlovic, M., Wilmer, M., Rüth, M., Masereeuw, R., & Stamatialis, D. (2016). Upscaling of a living membrane for bioartificial kidney device. European Journal of Pharmacology, 790, 28-35. https://doi.org/10.1016/j.ejphar.2016.07.009
https://dspace.library.uu.nl/bitstream/handle/1874/432800/1-s2.0-S0014299916304393-main.pdf?sequence=1
Jansen, J., Fedecostante, M., Wilmer, M. J., Peters, J. G., Kreuser, U. M., van den Broek, P. H., Mensink, R. A., Boltje, T. J., Stamatialis, D., Wetzels, J. F., van den Heuvel, L. P., Hoenderop, J. G., & Masereeuw, R. (2016). Bioengineered kidney tubules efficiently excrete uremic toxins. Scientific Reports, 6, Article 6:26715. https://doi.org/10.1038/srep26715
Peters, E., Heuberger, J. A. A. C., Tiessen, R., van Elsas, A., Masereeuw, R., Arend, J., Stevens, J., & Pickkers, P. (2016). Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers. Clinical Pharmacokinetics, 55, 1227–1237. https://doi.org/10.1007/s40262-016-0399-y
Caetano-Pinto, P., Janssen, M. J., Gijzen, L., Verscheijden, L., Wilmer, M. J. G., & Masereeuw, R. (2016). Fluorescence-Based Transport Assays Revisited in a Human Renal Proximal Tubule Cell Line. Molecular Pharmaceutics, 13, 933-944. https://doi.org/10.1021/acs.molpharmaceut.5b00821
van Swelm, R. P. L., Wetzels, J. F. M., Verweij, V. G. M., Laarakkers, C. M. M., Pertijs, J. C. L. M., van der Wijst, J., Thévenod, F., Masereeuw, R., & Swinkels, D. W. (2016). Renal Handling of Circulating and Renal-Synthesized Hepcidin and Its Protective Effects against Hemoglobin-Mediated Kidney Injury. Journal of the American Society of Nephrology, 27(9), 2720-2732. https://doi.org/10.1681/ASN.2015040461
Nieskens, T. T. G., Peters, J. G. P., Schreurs, M. J., Smits, N., Woestenenk, R., Jansen, K., van der Made, T. K., Röring, M., Hilgendorf, C., Wilmer, M. J., & Masereeuw, R. (2016). A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. The AAPS journal, 18(2), 465-475. https://doi.org/10.1208/s12248-016-9871-8
Gozalpour, E., Wilmer, M., Bilos, A., Masereeuw, R., Russel, F. G. M., & Koenderink, J. B. (2016). Heterogeneous transport of digitalis-like compounds by P-glycoprotein in vesicular and cellular assays. Toxicology in Vitro, 32, 138-145. https://doi.org/10.1016/j.tiv.2015.12.009
Wilmer, M. J., Ng, C. P., Lanz, H. L., Vulto, P., Suter-Dick, L., & Masereeuw, R. (2016). Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening. Trends in Biotechnology, 34(2), 156-170. https://doi.org/10.1016/j.tibtech.2015.11.001

2015

Scholarly publications

Jansen, J., De Napoli, I. E., Fedecostante, M., Schophuizen, C. M. S., Chevtchik, N. V., Wilmer, M. J., van Asbeck, A. H., Croes, H. J., Pertijs, J. C., Wetzels, J. F. M., Hilbrands, L. B., van den Heuvel, L. P., Hoenderop, J. G., Stamatialis, D., & Masereeuw, R. (2015). Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations. Scientific Reports, 5, Article 16702. https://doi.org/10.1038/srep16702
Poesen, R., Mutsaers, H. A. M., Windey, K., van den Broek, P. H., Verweij, V., Augustijns, P., Kuypers, D., Jansen, J., Evenepoel, P., Verbeke, K., Meijers, B., & Masereeuw, R. (2015). The Influence of Dietary Protein Intake on Mammalian Tryptophan and Phenolic Metabolites. PLoS One, 10(10), e0140820. https://doi.org/10.1371/journal.pone.0140820
Peters, E., Stevens, J., Arend, J., Guan, Z., Raaben, W., Laverman, P., Elsas, A. V., Masereeuw, R., & Pickkers, P. (2015). Biodistribution and translational pharmacokinetic modeling of a human recombinant alkaline phosphatase. International Journal of Pharmaceutics, 495(1), 122-131. https://doi.org/10.1016/j.ijpharm.2015.08.090
https://dspace.library.uu.nl/bitstream/handle/1874/320374/biodistribution.pdf?sequence=1
Mutsaers, H. A. M., Caetano Pinto, P., Seegers, A. E. M., Dankers, A. C. A., van den Broek, P. H. H., Wetzels, J. F. M., van den Brand, J. A. J. G., van den Heuvel, L. P., Hoenderop, J. G., Wilmer, M. J. G., & Masereeuw, R. (2015). Proximal tubular efflux transporters involved in renal excretion of p-cresyl sulfate and p-cresyl glucuronide: Implications for chronic kidney disease pathophysiology. Toxicology in Vitro, 29(7), 1868-1877. https://doi.org/10.1016/j.tiv.2015.07.020
Peters, E., Geraci, S., Heemskerk, S., Wilmer, M. J., Bilos, A., Kraenzlin, B., Gretz, N., Pickkers, P., & Masereeuw, R. (2015). Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate. British Journal of Pharmacology, 172(20), 4932-4945. https://doi.org/10.1111/bph.13261
Schophuizen, C. M. S., De Napoli, I. E., Jansen, J., Teixeira, S., Wilmer, M. J., Hoenderop, J. G. J., Van den Heuvel, L. P. W., Masereeuw, R., & Stamatialis, D. (2015). Development of a living membrane comprising a functional human renal proximal tubule cell monolayer on polyethersulfone polymeric membrane. Acta Biomaterialia, 14, 22-32. https://doi.org/10.1016/j.actbio.2014.12.002
Knops, N., van den Heuvel, L. P., Masereeuw, R., Bongaers, I., de Loor, H., Levtchenko, E., & Kuypers, D. (2015). The functional implications of common genetic variation in CYP3A5 and ABCB1 in human proximal tubule cells. Molecular Pharmaceutics, 12(3), 758-68. https://doi.org/10.1021/mp500590s
Schophuizen, C. M. S., Hoenderop, J. G. J., Masereeuw, R., & Heuvel, L. P. V. D. (2015). Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. Cells, 4(3), 234-52. https://doi.org/10.3390/cells4030234

Professional publications

Mutsaers, H. A. M., Masereeuw, R., & Olinga, P. (2015). The Authors Reply. Kidney International, 88(3), 637-637. https://doi.org/10.1038/ki.2015.188
https://dspace.library.uu.nl/bitstream/handle/1874/320381/ki2015188a.pdf?sequence=1

2014

Scholarly publications

van Swelm, R. P. L., Hadi, M., Laarakkers, C. M. M., Masereeuw, R., Groothuis, G. M. M., & Russel, F. G. M. (2014). Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury. Journal of applied toxicology, 34(9), 993-1001. https://doi.org/10.1002/jat.2917
Peters, E., Heemskerk, S., Masereeuw, R., & Pickkers, P. (2014). Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients. American Journal of Kidney Diseases, 63(6), 1038-48. https://doi.org/10.1053/j.ajkd.2013.11.027
El-Sheikh, A. A. K., Koenderink, J. B., Wouterse, A. C., van den Broek, P. H. H., Verweij, V. G. M., Masereeuw, R., & Russel, F. G. M. (2014). Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus. Translational Research, 164(1), 46-56. https://doi.org/10.1016/j.trsl.2014.01.006
Jansen, J., Schophuizen, C. M. S., Wilmer, M. J., Lahham, S. H. M., Mutsaers, H. A. M., Wetzels, J. F. M., Bank, R. A., van den Heuvel, L. P., Hoenderop, J. G., & Masereeuw, R. (2014). A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue. Experimental Cell Research, 323(1), 87-99. https://doi.org/10.1016/j.yexcr.2014.02.011
Mutsaers, H. A. M., Levtchenko, E. N., Martinerie, L., Pertijs, J. C. L. M., Allegaert, K., Devriendt, K., Masereeuw, R., Monnens, L. A. H., & Lombès, M. (2014). Switch in FGFR3 and -4 expression profile during human renal development may account for transient hypercalcemia in patients with Sotos syndrome due to 5q35 microdeletions. Journal of Clinical Endocrinology and Metabolism, 99(7), E1361-7. https://doi.org/10.1210/jc.2014-1123
Masereeuw, R., Mutsaers, H. A. M., Toyohara, T., Abe, T., Jhawar, S., Sweet, D. H., & Lowenstein, J. (2014). The kidney and uremic toxin removal: glomerulus or tubule? Seminars in Nephrology, 34(2), 191-208. https://doi.org/10.1016/j.semnephrol.2014.02.010
Jansen, J., Fedecostante, M., Wilmer, M. J., van den Heuvel, L. P., Hoenderop, J. G., & Masereeuw, R. (2014). Biotechnological challenges of bioartificial kidney engineering. Biotechnology Advances, 32(7), 1317-27. https://doi.org/10.1016/j.biotechadv.2014.08.001
van Swelm, R. P. L., Kramers, C., Masereeuw, R., & Russel, F. G. M. (2014). Application of urine proteomics for biomarker discovery in drug-induced liver injury. Critical Reviews in Toxicology, 44(10), 823-41. https://doi.org/10.3109/10408444.2014.931341
Gozalpour, E., Greupink, R., Bilos, A., Verweij, V., van den Heuvel, J. J. M. W., Masereeuw, R., Russel, F. G. M., & Koenderink, J. B. (2014). Convallatoxin: a new P-glycoprotein substrate. European Journal of Pharmacology, 744, 18-27. https://doi.org/10.1016/j.ejphar.2014.09.031
Peters, E., Masereeuw, R., & Pickkers, P. (2014). The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury. Nephron. Clinical practice, 127(1-4), 144-8. https://doi.org/10.1159/000363256

Professional publications

Mutsaers, H. A. M., Masereeuw, R., & Olinga, P. (2014). Altered tryptophan metabolism and CKD-associated fatigue. Kidney International, 86(5), 1061-2. https://doi.org/10.1038/ki.2014.237

2013

Scholarly publications

Masereeuw, R., Draisma, A., Heemskerk, S., Bouw, M. P. W. J. M., Laarakkers, C., van der Hoeven, J. G., & Pickkers, P. (2013). Potential new markers of inflammation-induced renal injury subside when endotoxin tolerance develops in humans. Journal of Proteomics and Bioinformatics, 6(3), 58-64. https://doi.org/10.4172/jpb.1000262
Moghadasali, R., Mutsaers, H. A. M., Azarnia, M., Aghdami, N., Baharvand, H., Torensma, R., Wilmer, M. J. G., & Masereeuw, R. (2013). Mesenchymal stem cell-conditioned medium accelerates regeneration of human renal proximal tubule epithelial cells after gentamicin toxicity. Experimental and Toxicologic Pathology, 65(5), 595-600. https://doi.org/10.1016/j.etp.2012.06.002
Mutsaers, H. A. M., Wilmer, M. J. G., Reijnders, D., Jansen, J., van den Broek, P. H. H., Forkink, M., Schepers, E., Glorieux, G., Vanholder, R., van den Heuvel, L. P., Hoenderop, J. G., & Masereeuw, R. (2013). Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration. Biochimica et Biophysica Acta, 1832(1), 142-50. https://doi.org/10.1016/j.bbadis.2012.09.006
Wagener, F. A. D. T. G., Dankers, A. C. A., van Summeren, F., Scharstuhl, A., van den Heuvel, J. J. M. W., Koenderink, J. B., Pennings, S. W. C., Russel, F. G. M., & Masereeuw, R. (2013). Heme Oxygenase-1 and breast cancer resistance protein protect against heme-induced toxicity. Current Pharmaceutical Design, 19(15), 2698-707. https://doi.org/10.2174/1381612811319150004
Peters, E., van Elsas, A., Heemskerk, S., Jonk, L., van der Hoeven, J., Arend, J., Masereeuw, R., & Pickkers, P. (2013). Alkaline phosphatase as a treatment of sepsis-associated acute kidney injury. Journal of Pharmacology and Experimental Therapeutics, 344(1), 2-7. https://doi.org/10.1124/jpet.112.198226
Wever, K. E., Masereeuw, R., Wagener, F. A., Verweij, V. G. M., Peters, J. G. P., Pertijs, J. C. L. M., Van der Vliet, J. A., Warlé, M. C., & Rongen, G. A. (2013). Humoral signalling compounds in remote ischaemic preconditioning of the kidney, a role for the opioid receptor. Nephrology Dialysis Transplantation, 28(7), 1721-32. https://doi.org/10.1093/ndt/gfs601
Besouw, M., Masereeuw, R., van den Heuvel, L., & Levtchenko, E. (2013). Cysteamine: an old drug with new potential. Drug Discovery Today, 18(15-16), 785-92. https://doi.org/10.1016/j.drudis.2013.02.003
van Swelm, R. P. L., Laarakkers, C. M. M., Pertijs, J. C. L. M., Verweij, V., Masereeuw, R., & Russel, F. G. M. (2013). Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicology and Applied Pharmacology, 269(2), 141-9. https://doi.org/10.1016/j.taap.2013.03.005
Peters, H. P. E., Laarakkers, C. M. M., Pickkers, P., Masereeuw, R., Boerman, O. C., Eek, A., Cornelissen, E. A. M., Swinkels, D. W., & Wetzels, J. F. M. (2013). Tubular reabsorption and local production of urine hepcidin-25. BMC Nephrology, 14, 70. https://doi.org/10.1186/1471-2369-14-70
Dankers, A. C. A., Mutsaers, H. A. M., Dijkman, H. B. P. M., van den Heuvel, L. P., Hoenderop, J. G., Sweep, F. C. G. J., Russel, F. G. M., & Masereeuw, R. (2013). Hyperuricemia influences tryptophan metabolism via inhibition of multidrug resistance protein 4 (MRP4) and breast cancer resistance protein (BCRP). Biochimica et Biophysica Acta, 1832(10), 1715-22. https://doi.org/10.1016/j.bbadis.2013.05.002
Martines, A. M. F., Masereeuw, R., Tjalsma, H., Hoenderop, J. G., Wetzels, J. F. M., & Swinkels, D. W. (2013). Iron metabolism in the pathogenesis of iron-induced kidney injury. Nature Reviews. Nephrology, 9(7), 385-98. https://doi.org/10.1038/nrneph.2013.98
van Geffen, M., Mathijssen, N. C. J., Holme, P. A., Laros-van Gorkom, B. A. P., van Kraaij, M. G. J., Masereeuw, R., Peyvandi, F., & van Heerde, W. L. (2013). Pharmacodynamics of recombinant activated factor VII and plasma-derived factor VII in a cohort of severe FVII deficient patients. Thrombosis Research, 132(1), 116-22. https://doi.org/10.1016/j.thromres.2013.04.021
Schophuizen, C. M. S., Wilmer, M. J., Jansen, J., Gustavsson, L., Hilgendorf, C., Hoenderop, J. G. J., van den Heuvel, L. P., & Masereeuw, R. (2013). Cationic uremic toxins affect human renal proximal tubule cell functioning through interaction with the organic cation transporter. Pflugers Archiv-European Journal of Physiology, 465(12), 1701-14. https://doi.org/10.1007/s00424-013-1307-z
van Swelm, R. P. L., Laarakkers, C. M. M., Kooijmans-Otero, M., de Jong, E. M. G. J., Masereeuw, R., & Russel, F. G. M. (2013). Biomarkers for methotrexate-induced liver injury: urinary protein profiling of psoriasis patients. Toxicology Letters, 221(3), 219-24. https://doi.org/10.1016/j.toxlet.2013.06.234
Mathijssen, N. C. J., Masereeuw, R., Holme, P. A., van Kraaij, M. G. J., Laros-van Gorkom, B. A. P., Peyvandi, F., & van Heerde, W. L. (2013). Increased volume of distribution for recombinant activated factor VII and longer plasma-derived factor VII half-life may explain their long lasting prophylactic effect. Thrombosis Research, 132(2), 256-62. https://doi.org/10.1016/j.thromres.2013.05.027
Hosper, N. A., van den Berg, P. P., de Rond, S., Popa, E. R., Wilmer, M. J., Masereeuw, R., & Bank, R. A. (2013). Epithelial-to-mesenchymal transition in fibrosis: collagen type I expression is highly upregulated after EMT, but does not contribute to collagen deposition. Experimental Cell Research, 319(19), 3000-9. https://doi.org/10.1016/j.yexcr.2013.07.014
Mutsaers, H. A. M., Engelke, U. F. H., Wilmer, M. J. G., Wetzels, J. F. M., Wevers, R. A., van den Heuvel, L. P., Hoenderop, J. G., & Masereeuw, R. (2013). Optimized metabolomic approach to identify uremic solutes in plasma of stage 3-4 chronic kidney disease patients. PLoS One, 8(8), e71199. https://doi.org/10.1371/journal.pone.0071199
Dankers, A. C. A., Roelofs, M. J. E., Piersma, A. H., Sweep, F. C. G. J., Russel, F. G. M., van den Berg, M., van Duursen, M. B. M., & Masereeuw, R. (2013). Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro. Toxicological Sciences, 136(2), 382-391. https://doi.org/10.1093/toxsci/kft198
El-Sheikh, A. A. K., Greupink, R., Wortelboer, H. M., van den Heuvel, J. J. M. W., Schreurs, M., Koenderink, J. B., Masereeuw, R., & Russel, F. G. M. (2013). Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4. Translational Research, 162(6), 398-409. https://doi.org/10.1016/j.trsl.2013.08.003

Professional publications

Masereeuw, R. (Guest ed.) (2013). Drug disposition: from cradle to cane. International Journal of Pharmaceutics, 452(1-2), 1-2. https://doi.org/10.1016/j.ijpharm.2013.05.035

2012

Scholarly publications

Dardikh, M., Albert, T., Masereeuw, R., Oldenburg, J., Novakova, I., van Heerde, W. L., & Verbruggen, B. (2012). Low-titre inhibitors, undetectable by the Nijmegen assay, reduce factor VIII half-life after immune tolerance induction. Journal of Thrombosis and Haemostasis, 10(4), 706-8. https://doi.org/10.1111/j.1538-7836.2012.04645.x
Engbersen, R., Masereeuw, R., van Gestel, M. A., Siero, H. L. M., Moons, M. M., Smits, P., & Russel, F. G. M. (2012). Differential effects of sulfonylurea derivatives on vascular ATP-sensitive potassium channels. European Journal of Pharmacology, 681(1-3), 75-9. https://doi.org/10.1016/j.ejphar.2012.02.006
Wever, K. E., Menting, T. P., Rovers, M., van der Vliet, J. A., Rongen, G. A., Masereeuw, R., Ritskes-Hoitinga, M., Hooijmans, C. R., & Warlé, M. (2012). Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis. PLoS One, 7(2), e32296. https://doi.org/10.1371/journal.pone.0032296
Dankers, A. C. A., Sweep, F. C. G. J., Pertijs, J. C. L. M., Verweij, V., van den Heuvel, J. J. M. W., Koenderink, J. B., Russel, F. G. M., & Masereeuw, R. (2012). Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell and Tissue Research, 349(2), 551-63. https://doi.org/10.1007/s00441-012-1417-5
van Swelm, R. P. L., Laarakkers, C. M. M., Blous, L., Peters, J. G. P., Blaney Davidson, E. N., van der Kraan, P. M., Swinkels, D. W., Masereeuw, R., & Russel, F. G. M. (2012). Acute acetaminophen intoxication leads to hepatic iron loading by decreased hepcidin synthesis. Toxicological Sciences, 129(1), 225-33. https://doi.org/10.1093/toxsci/kfs176
Ramakers, B. P., Wever, K. E., Kox, M., van den Broek, P. H., Mbuyi, F., Rongen, G., Masereeuw, R., van der Hoeven, J. G., Smits, P., Riksen, N. P., & Pickkers, P. (2012). How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo. Critical Care Medicine, 40(9), 2609-16. https://doi.org/10.1097/CCM.0b013e318259205b
Wever, K. E., Menting, T., Masereeuw, R., van der Vliet, J. A., Rongen, G. A., & Warlé, M. C. (2012). Local and remote ischemic postconditionings have synergistic protective effects on renal ischemia-reperfusion injury. Transplantation, 94(1), e1-2. https://doi.org/10.1097/TP.0b013e318257ad76
Masereeuw, R., & Russel, F. G. M. (2012). Regulatory pathways for ATP-binding cassette transport proteins in kidney proximal tubules. The AAPS journal, 14(4), 883-94. https://doi.org/10.1208/s12248-012-9404-z
Dieteren, C. E. J., Koopman, W. J. H., Swarts, H. G., Peters, J. G. P., Maczuga, P., van Gemst, J. J., Masereeuw, R., Smeitink, J. A. M., Nijtmans, L. G. J., & Willems, P. H. G. M. (2012). Subunit-specific incorporation efficiency and kinetics in mitochondrial complex I homeostasis. Journal of Biological Chemistry, 287(50), 41851-60. https://doi.org/10.1074/jbc.M112.391151
van Swelm, R. P. L., Laarakkers, C. M. M., van der Kuur, E. C., Morava-Kozicz, E., Wevers, R. A., Augustijn, K. D., Touw, D. J., Sandel, M. H., Masereeuw, R., & Russel, F. G. M. (2012). Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice. PLoS One, 7(11), e49524. https://doi.org/10.1371/journal.pone.0049524

2011

Scholarly publications

Tjalsma, H., Laarakkers, C. M. M., van Swelm, R. P. L., Theurl, M., Theurl, I., Kemna, E. H., van der Burgt, Y. E. M., Venselaar, H., Dutilh, B. E., Russel, F. G. M., Weiss, G., Masereeuw, R., Fleming, R. E., & Swinkels, D. W. (2011). Mass Spectrometry Analysis of Hepcidin Peptides in Experimental Mouse Models. PLoS One, 6(3), Article e16762. https://doi.org/10.1371/journal.pone.0016762
Schreuder, M. F., Bueters, R. R., Huigen, M. C., Russel, F. G. M., Masereeuw, R., & van den Heuvel, L. P. (2011). Effect of drugs on renal development. Clinical Journal of the American Society of Nephrology, 6(1), 212-7. https://doi.org/10.2215/CJN.04740510
Peeters, K., Wilmer, M. J., Schoeber, J. P., Reijnders, D., Heuvel, L. P. V. D., Masereeuw, R., & Levtchenko, E. (2011). Role of p-glycoprotein expression and function in cystinotic renal proximal tubular cells. Molecular Pharmaceutics, 3(4), 782-92. https://doi.org/10.3390/pharmaceutics3040782
Rennings, A. J., Russel, F. G., Li, Y., Deen, P. M., Masereeuw, R., Tack, C. J., & Smits, P. (2011). Preserved response to diuretics in rosiglitazone-treated subjects with insulin resistance: a randomized double-blind placebo-controlled crossover study. Clinical Pharmacology and Therapeutics, 89(4), 587-94. https://doi.org/10.1038/clpt.2010.360
Wilmer, M. J., Kluijtmans, L. A. J., van der Velden, T. J., Willems, P. H., Scheffer, P. G., Masereeuw, R., Monnens, L. A., van den Heuvel, L. P., & Levtchenko, E. N. (2011). Cysteamine restores glutathione redox status in cultured cystinotic proximal tubular epithelial cells. Biochimica et Biophysica Acta, 1812(6), 643-51. https://doi.org/10.1016/j.bbadis.2011.02.010
van den Boogaard, M., van Swelm, R. P., Russel, F. G., Heemskerk, S., van der Hoeven, J. G., Masereeuw, R., & Pickkers, P. (2011). Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients. Proteome Science [E], 9, 13. https://doi.org/10.1186/1477-5956-9-13
Wever, K. E., Warlé, M. C., Wagener, F. A., van der Hoorn, J. W., Masereeuw, R., van der Vliet, J. A., & Rongen, G. A. (2011). Remote ischaemic preconditioning by brief hind limb ischaemia protects against renal ischaemia-reperfusion injury: the role of adenosine. Nephrology Dialysis Transplantation, 26(10), 3108-17. https://doi.org/10.1093/ndt/gfr103
Mutsaers, H. A. M., van den Heuvel, L. P., Ringens, L. H. J., Dankers, A. C. A., Russel, F. G. M., Wetzels, J. F. M., Hoenderop, J. G., & Masereeuw, R. (2011). Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations. PLoS One, 6(4), e18438. https://doi.org/10.1371/journal.pone.0018438
Prevoo, B., Miller, D. S., van de Water, F. M., Wever, K. E., Russel, F. G. M., Flik, G., & Masereeuw, R. (2011). Rapid, nongenomic stimulation of multidrug resistance protein 2 (Mrp2) activity by glucocorticoids in renal proximal tubule. Journal of Pharmacology and Experimental Therapeutics, 338(1), 362-71. https://doi.org/10.1124/jpet.111.179689
Wever, K. E., Wagener, F. A. D. T. G., Frielink, C., Boerman, O. C., Scheffer, G. J., Allison, A., Masereeuw, R., & Rongen, G. A. (2011). Diannexin protects against renal ischemia reperfusion injury and targets phosphatidylserines in ischemic tissue. PLoS One, 6(8), e24276. https://doi.org/10.1371/journal.pone.0024276
Mutsaers, H. A. M., Wilmer, M. J. G., van den Heuvel, L. P., Hoenderop, J. G., & Masereeuw, R. (2011). Basolateral transport of the uraemic toxin p-cresyl sulfate: role for organic anion transporters? Nephrology Dialysis Transplantation, 26(12), 4149. https://doi.org/10.1093/ndt/gfr562

2010

Scholarly publications

Wilmer, M. J., Saleem, M. A., Masereeuw, R., Ni, L., van der Velden, T. J., Russel, F. G., Mathieson, P. W., Monnens, L. A., van den Heuvel, L. P., & Levtchenko, E. N. (2010). Novel conditionally immortalized human proximal tubule cell line expressing functional influx and efflux transporters. Cell and Tissue Research, 339(2), 449-57. https://doi.org/10.1007/s00441-009-0882-y
Masereeuw, R., & Russel, F. G. M. (2010). Therapeutic implications of renal anionic drug transporters. Pharmacology & Therapeutics, 126(2), 200-16. https://doi.org/10.1016/j.pharmthera.2010.02.007
Heemskerk, S., Peters, J. G. P., Louisse, J., Sagar, S., Russel, F. G. M., & Masereeuw, R. (2010). Regulation of P-glycoprotein in renal proximal tubule epithelial cells by LPS and TNF-alpha. Journal of Biomedicine and Biotechnology, 2010, 525180. https://doi.org/10.1155/2010/525180
Vegt, E., de Jong, M., Wetzels, J. F. M., Masereeuw, R., Melis, M., Oyen, W. J. G., Gotthardt, M., & Boerman, O. C. (2010). Renal toxicity of radiolabeled peptides and antibody fragments: mechanisms, impact on radionuclide therapy, and strategies for prevention. Journal of Nuclear Medicine, 51(7), 1049-58. https://doi.org/10.2967/jnumed.110.075101
Reichel, V., Kläs, J., Fricker, G., & Masereeuw, R. (2010). Fluo-cAMP is transported by multidrug resistance-associated protein isoform 4 in rat choroid plexus. Journal of Neurochemistry, 115(1), 200-8. https://doi.org/10.1111/j.1471-4159.2010.06915.x
Huls, M., Schoeber, J. P. H., Verfaillie, C. M., Luttun, A., Ulloa-Montoya, F., Menke, A. L., van Bolderen, L. R., Woestenenk, R. M., Merkx, G. F. M., Wetzels, J. F. M., Russel, F. G. M., & Masereeuw, R. (2010). Deficiency of either P-glycoprotein or breast cancer resistance protein protect against acute kidney injury. Cell Transplantation, 19(9), 1195-208. https://doi.org/10.3727/096368910X504478

2009

Scholarly publications

Huls, M., Russel, F. G. M., & Masereeuw, R. (2009). The role of ATP binding cassette transporters in tissue defense and organ regeneration. Journal of Pharmacology and Experimental Therapeutics, 328(1), 3-9. https://doi.org/10.1124/jpet.107.132225
Heemskerk, S., Masereeuw, R., Moesker, O., Bouw, M. P. W. J. M., van der Hoeven, J. G., Peters, W. H. M., Russel, F. G. M., APSEP Study Group, & Pickkers, P. (2009). Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Critical Care Medicine, 37(2), 417-23, e1. https://doi.org/10.1097/CCM.0b013e31819598af
Huynh, L., Masereeuw, R., Friedberg, T., Ingelman-Sundberg, M., & Manivet, P. (2009). In silico platform for xenobiotics ADME-T pharmacological properties modeling and prediction. Part I: Beyond the reduction of animal model use. Drug Discovery Today, 14(7-8), 401-5.
Heemskerk, S., Masereeuw, R., Russel, F. G. M., & Pickkers, P. (2009). Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury. Nature Reviews. Nephrology, 5(11), 629-40. https://doi.org/10.1038/nrneph.2009.155
Masereeuw, R. (2009). Contribution of bone marrow-derived cells in renal repair after acute kidney injury. Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 61(4), 373-84.

2008

Scholarly publications

Heemskerk, S., van Haren, F. M. P., Foudraine, N. A., Peters, W. H. M., van der Hoeven, J. G., Russel, F. G. M., Masereeuw, R., & Pickkers, P. (2008). Short-term beneficial effects of methylene blue on kidney damage in septic shock patients. Intensive Care Medicine, 34(2), 350-4. https://doi.org/10.1007/s00134-007-0867-9
Huls, M., Brown, C. D. A., Windass, A. S., Sayer, R., van den Heuvel, J. J. M. W., Heemskerk, S., Russel, F. G. M., & Masereeuw, R. (2008). The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane. Kidney International, 73(2), 220-5. https://doi.org/10.1038/sj.ki.5002645
Denissen, N. H. A. M., Peters, J. G. P., Masereeuw, R., & Barrera, P. (2008). Can sulfasalazine therapy induce or exacerbate Wegener's granulomatosis? Scandinavian Journal of Rheumatology, 37(1), 72-4. https://doi.org/10.1080/03009740701607117
Heemskerk, S., Wouterse, A. C., Russel, F. G. M., & Masereeuw, R. (2008). Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia. European Journal of Pharmacology, 584(2-3), 390-7. https://doi.org/10.1016/j.ejphar.2008.02.006
Russel, F. G. M., Koenderink, J. B., & Masereeuw, R. (2008). Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules. Trends in Pharmacological Sciences, 29(4), 200-7. https://doi.org/10.1016/j.tips.2008.01.006
Huls, M., Russel, F. G. M., & Masereeuw, R. (2008). Insights into the role of bone marrow-derived stem cells in renal repair. Kidney & Blood Pressure Research, 31(2), 104-10. https://doi.org/10.1159/000121387
El-Sheikh, A. A. K., Masereeuw, R., & Russel, F. G. M. (2008). Mechanisms of renal anionic drug transport. European Journal of Pharmacology, 585(2-3), 245-55. https://doi.org/10.1016/j.ejphar.2008.02.085
Vegt, E., van Eerd, J. E. M., Eek, A., Oyen, W. J. G., Wetzels, J. F. M., de Jong, M., Russel, F. G. M., Masereeuw, R., Gotthardt, M., & Boerman, O. C. (2008). Reducing renal uptake of radiolabeled peptides using albumin fragments. Journal of Nuclear Medicine, 49(9), 1506-11. https://doi.org/10.2967/jnumed.108.053249

2007

Scholarly publications

Wever, K. E., Masereeuw, R., Masereeuw, R., Miller, D. S., Hang, X. M., & Flik, G. (2007). Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport. American Journal of Physiology-Renal Physiology, 292(1), F38-46. https://doi.org/10.1152/ajprenal.00479.2005
van de Water, F. M., Boleij, J. M., Peters, J. G. P., Russel, F. G. M., & Masereeuw, R. (2007). Characterization of P-glycoprotein and multidrug resistance proteins in rat kidney and intestinal cell lines. European Journal of Pharmaceutical Sciences, 30(1), 36-44. https://doi.org/10.1016/j.ejps.2006.09.008
Heemskerk, S., van Koppen, A., van den Broek, L., Poelen, G. J. M., Wouterse, A. C., Dijkman, H. B. P. M., Russel, F. G. M., & Masereeuw, R. (2007). Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. Pflugers Archiv-European Journal of Physiology, 454(2), 321-34. https://doi.org/10.1007/s00424-007-0210-x
Vanhoutte, K. J. A., Laarakkers, C., Marchiori, E., Pickkers, P., Wetzels, J. F. M., Willems, J. L., van den Heuvel, L. P., Russel, F. G. M., & Masereeuw, R. (2007). Biomarker discovery with SELDI-TOF MS in human urine associated with early renal injury: evaluation with computational analytical tools. Nephrology Dialysis Transplantation, 22(10), 2932-43. https://doi.org/10.1093/ndt/gfm170
Heemskerk, S., Masereeuw, R., van der Hoeven, H., & Pickkers, P. (2007). Renal effects of nitric oxide during sepsis: another two-edged sword? American Journal of Respiratory and Critical Care Medicine, 176(4), 419-20; author reply 420. https://doi.org/10.1164/ajrccm.176.4.419
Huls, M., Kramers, C., Levtchenko, E. N., Wilmer, M. J. G., Dijkman, H. B. P. M., Kluijtmans, L. A. J., van der Hoorn, J. W. A., Russel, F. G. M., & Masereeuw, R. (2007). P-glycoprotein-deficient mice have proximal tubule dysfunction but are protected against ischemic renal injury. Kidney International, 72(10), 1233-41. https://doi.org/10.1038/sj.ki.5002522
Reichel, V., Masereeuw, R., van den Heuvel, J. J. M. W., Miller, D. S., & Fricker, G. (2007). Transport of a fluorescent cAMP analog in teleost proximal tubules. American journal of physiology. Regulatory integrative comparative physiology, 293(6), R2382-9. https://doi.org/10.1152/ajpregu.00029.2007

2006

Scholarly publications

Van Eerd, J. E. M., Vegt, E., Wetzels, J. F. M., Russel, F. G. M., Masereeuw, R., Corstens, F. H. M., Boerman, O. C., & Oyen, W. J. G. (2006). Reply: Inhibition of kidney uptake of radiolabeled somatostatin analogs: Amino acids or gelofusine? [2]. Journal of Nuclear Medicine, 47(10).
Vegt, E., Wetzels, J. F. M., Russel, F. G. M., Masereeuw, R., Boerman, O. C., van Eerd, J. E., Corstens, F. H. M., & Oyen, W. J. G. (2006). Renal uptake of radiolabeled octreotide in human subjects is efficiently inhibited by succinylated gelatin. Journal of Nuclear Medicine, 47(3), 432-6.
van Eerd, J. E. M., Vegt, E., Wetzels, J. F. M., Russel, F. G. M., Masereeuw, R., Corstens, F. H. M., Oyen, W. J. G., & Boerman, O. C. (2006). Gelatin-based plasma expander effectively reduces renal uptake of 111In-octreotide in mice and rats. Journal of Nuclear Medicine, 47(3), 528-33.
Huls, M., van den Heuvel, J. J. M. W., Dijkman, H. B. P. M., Russel, F. G. M., & Masereeuw, R. (2006). ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney. Kidney International, 69(12), 2186-93. https://doi.org/10.1038/sj.ki.5000407
van de Water, F. M., Boerman, O. C., Wouterse, A. C., Peters, J. G. P., Russel, F. G. M., & Masereeuw, R. (2006). Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules. Drug Metabolism and Disposition, 34(8), 1393-7. https://doi.org/10.1124/dmd.106.009555
Notenboom, S., Wouterse, A. C., Peters, B., Kuik, L. H., Heemskerk, S., Russel, F. G. M., & Masereeuw, R. (2006). Increased apical insertion of the multidrug resistance protein 2 (MRP2/ABCC2) in renal proximal tubules following gentamicin exposure. Journal of Pharmacology and Experimental Therapeutics, 318(3), 1194-202. https://doi.org/10.1124/jpet.106.104547
van de Water, F. M., Russel, F. G. M., & Masereeuw, R. (2006). Regulation and expression of endothelin-1 (ET-1) and ET-receptors in rat epithelial cells of renal and intestinal origin. Pharmacological Research, 54(6), 429-35. https://doi.org/10.1016/j.phrs.2006.08.006
Heemskerk, S., Pickkers, P., Bouw, M. P. W. J. M., Draisma, A., van der Hoeven, J. G., Peters, W. H. M., Smits, P., Russel, F. G. M., & Masereeuw, R. (2006). Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury. Clinical Journal of the American Society of Nephrology, 1(4), 853-62. https://doi.org/10.2215/CJN.00490206

2005

Scholarly publications

Engbersen, R., Masereeuw, R., van Gestel, M. A., van der Logt, E. M. J., Smits, P., & Russel, F. G. M. (2005). Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism. British Journal of Pharmacology, 145(8), 1069-75. https://doi.org/10.1038/sj.bjp.0706275
Notenboom, S., Miller, D. S., Kuik, L. H., Smits, P., Russel, F. G. M., & Masereeuw, R. (2005). Short-term exposure of renal proximal tubules to gentamicin increases long-term multidrug resistance protein 2 (Abcc2) transport function and reduces nephrotoxicant sensitivity. Journal of Pharmacology and Experimental Therapeutics, 315(2), 912-20. https://doi.org/10.1124/jpet.105.089094
van de Water, F. M., Masereeuw, R., & Russel, F. G. M. (2005). Function and regulation of multidrug resistance proteins (MRPs) in the renal elimination of organic anions. Drug Metabolism Reviews, 37(3), 443-71. https://doi.org/10.1080/03602530500205275

2004

Scholarly publications

Notenboom, S., Miller, D. S., Smits, P., Russel, F. G. M., & Masereeuw, R. (2004). Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule. American Journal of Physiology-Renal Physiology, 287(1), F33-8. https://doi.org/10.1152/ajprenal.00443.2003
Masereeuw, R., & Russel, F. (2004). Screening for the role of transporters in hepatic and renal drug handling. Drug Discovery Today. Technologies, 1(4), 357-64. https://doi.org/10.1016/j.ddtec.2004.11.006
Mathijssen, N. C. J., Masereeuw, R., Verbeek, K., Lavergne, J. M., Costa, J.-M., van Heerde, W. L., & Nováková, I. R. O. (2004). Prophylactic effect of recombinant factor VIIa in factor VII deficient patients. British Journal of Haematology, 125(4), 494-9. https://doi.org/10.1111/j.1365-2141.2004.04942.x

2003

Scholarly publications

Terlouw, S. A., Masereeuw, R., & Russel, F. G. M. (2003). Modulatory effects of hormones, drugs, and toxic events on renal organic anion transport. Biochemical Pharmacology, 65(9), 1393-405.
de Gier, R. P. E., Feitz, W. F. J., Masereeuw, R., Wouterse, A. C., Smits, D., & Russel, F. G. M. (2003). Anionic and cationic drug secretion in the isolated perfused rat kidney after neonatal surgical induction of ureteric obstruction. BJU International, 92(4), 452-8.
Masereeuw, R., Notenboom, S., Smeets, P. H. E., Wouterse, A. C., & Russel, F. G. M. (2003). Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats. Journal of the American Society of Nephrology, 14(11), 2741-9.

2002

Scholarly publications

Masereeuw, R., & Russel, F. G. (2002). Mechanisms and clinical implications of renal drug excretion. Drug Metabolism Reviews, 33(3-4), 299-351. https://doi.org/10.1081/DMR-120000654
Russel, F. G. M., Masereeuw, R., & van Aubel, R. A. M. H. (2002). Molecular aspects of renal anionic drug transport. Annual Review of Physiology, 64, 563-94. https://doi.org/10.1146/annurev.physiol.64.081501.155913
Miller, D. S., Masereeuw, R., & Karnaky, K. J. (2002). Regulation of MRP2-mediated transport in shark rectal salt gland tubules. American journal of physiology. Regulatory integrative comparative physiology, 282(3), R774-81. https://doi.org/10.1152/ajpregu.00333.2001
Notenboom, S., Miller, D. S., Smits, P., Russel, F. G. M., & Masereeuw, R. (2002). Role of NO in endothelin-regulated drug transport in the renal proximal tubule. American Journal of Physiology-Renal Physiology, 282(3), F458-64. https://doi.org/10.1152/ajprenal.00173.2001
Terlouw, S. A., Graeff, C., Smeets, P. H. E., Fricker, G., Russel, F. G. M., Masereeuw, R., & Miller, D. S. (2002). Short- and long-term influences of heavy metals on anionic drug efflux from renal proximal tubule. Journal of Pharmacology and Experimental Therapeutics, 301(2), 578-85.

2001

Scholarly publications

Terlouw, S. A., Masereeuw, R., Russel, F. G., & Miller, D. S. (2001). Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux. Molecular Pharmacology, 59(6), 1433-40.
Terlouw, S. A., Masereeuw, R., van den Broek, P. H., Notenboom, S., & Russel, F. G. (2001). Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells. British Journal of Pharmacology, 134(5), 931-8. https://doi.org/10.1038/sj.bjp.0704284
Smeets, M., Raymakers, R., Muus, P., Vierwinden, G., Linssen, P., Masereeuw, R., & de Witte, T. (2001). Cyclosporin increases cellular idarubicin and idarubicinol concentrations in relapsed or refractory AML mainly due to reduced systemic clearance. Leukemia, 15(1), 80-8.

2000

Scholarly publications

Masereeuw, R., Terlouw, S. A., van Aubel, R. A., Russel, F. G., & Miller, D. S. (2000). Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule. Molecular Pharmacology, 57(1), 59-67.
Terlouw, S. A., Tanriseven, O., Russel, F. G., & Masereeuw, R. (2000). Metabolite anion carriers mediate the uptake of the anionic drug fluorescein in renal cortical mitochondria. Journal of Pharmacology and Experimental Therapeutics, 292(3), 968-73.
van Oosterhout, Y. V., van Emst, L., Schattenberg, A. V., Tax, W. J., Ruiter, D. J., Spits, H., Nagengast, F. M., Masereeuw, R., Evers, S., de Witte, T., & Preijers, F. W. (2000). A combination of anti-CD3 and anti-CD7 ricin A-immunotoxins for the in vivo treatment of acute graft versus host disease. Blood, 95(12), 3693-701.
Van Aubel, R. A., Masereeuw, R., & Russel, F. G. (2000). Molecular pharmacology of renal organic anion transporters. American Journal of Physiology-Renal Physiology, 279(2), F216-32.
Masereeuw, R., van Pelt, A. P., van Os, S. H., Willems, P. H., Smits, P., & Russel, F. G. (2000). Probenecid interferes with renal oxidative metabolism: a potential pitfall in its use as an inhibitor of drug transport. British Journal of Pharmacology, 131(1), 57-62. https://doi.org/10.1038/sj.bjp.0703541
Van Aubel, R. A., Peters, J. G., Masereeuw, R., Van Os, C. H., & Russel, F. G. (2000). Multidrug resistance protein mrp2 mediates ATP-dependent transport of classic renal organic anion p-aminohippurate. American Journal of Physiology-Renal Physiology, 279(4), F713-7.

1999

Scholarly publications

Masereeuw, R., Moons, M. M., Toomey, B. H., Russel, F. G., & Miller, D. S. (1999). Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. Journal of Pharmacology and Experimental Therapeutics, 289(2), 1104-11.

1998

Scholarly publications

Karnaky, K. J., Masereeuw, R., Henson, J., & Miller, D. S. (1998). Active xenobiotic excretion by Elasmo-branch rectal salt gland (RG) tubules. FASEB Journal, 12(5).
Miller, D. S., Masereeuw, R., Henson, J., & Karnaky, K. J. (1998). Excretory transport of xenobiotics by dogfish shark rectal gland tubules. American Journal of Physiology, 275(3 Pt 2), R697-705.
Masereeuw, R., Moons, M. M., & Russel, F. G. (1998). Disposition of 4-methylbenzoylglycine in rat isolated perfused kidney and effects of hippurates on renal mitochondrial metabolism. Journal of Pharmacy and Pharmacology, 50(12), 1397-404.

1997

Scholarly publications

Masereeuw, R., Moons, M. M., Smits, P., & Russel, F. G. M. (1997). Excretion and accumulation of diatrizoate in the isolated perfused rat kidney. European Journal of Pharmaceutical Sciences, 5(5), 295-301. https://doi.org/10.1016/S0928-0987(97)00024-9
Masereeuw, R., Moons, W. M., & Russel, F. G. (1997). Saturable accumulation and diuretic activity of hydrochlorothiazide in the isolated perfused rat kidney. Pharmacology, 54(1), 33-42.
Masereeuw, R., Moons, M. M., & Russel, F. G. (1997). Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system. European Journal of Pharmacology, 321(3), 315-23.

1996

Scholarly publications

Masereeuw, R., Russel, F. G. M., & Miller, D. S. (1996). Active, na-lndependent, organic anion secretion in killifish renal proximal tubules. FASEB Journal, 10(3).
Masereeuw, R., Moons, M. M., & Russel, F. G. (1996). Renal excretion and accumulation kinetics of 2-methylbenzoylglycine in the isolated perfused rat kidney. Journal of Pharmacy and Pharmacology, 48(6), 560-5.
Masereeuw, R., Moons, M. M., Smits, P., & Russel, F. G. (1996). Glomerular filtration and saturable absorption of iohexol in the rat isolated perfused kidney. British Journal of Pharmacology, 119(1), 57-64.
Masereeuw, R., Saleming, W. C., Miller, D. S., & Russel, F. G. (1996). Interaction of fluorescein with the dicarboxylate carrier in rat kidney cortex mitochondria. Journal of Pharmacology and Experimental Therapeutics, 279(3), 1559-65.
Masereeuw, R., Russel, F. G., & Miller, D. S. (1996). Multiple pathways of organic anion secretion in renal proximal tubule revealed by confocal microscopy. American Journal of Physiology, 271(6 Pt 2), F1173-82.

1994

Scholarly publications

Masereeuw, R., Jaehde, U., Langemeijer, M. W., de Boer, A. G., & Breimer, D. D. (1994). In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors. Pharmaceutical Research, 11(2), 324-30.
Jaehde, U., Masereeuw, R., De Boer, A. G., Fricker, G., Nagelkerke, J. F., Vonderscher, J., & Breimer, D. D. (1994). Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells. Pharmaceutical Research, 11(3), 442-8.
Masereeuw, R., van den Bergh, E. J., Bindels, R. J., & Russel, F. G. (1994). Characterization of fluorescein transport in isolated proximal tubular cells of the rat: evidence for mitochondrial accumulation. Journal of Pharmacology and Experimental Therapeutics, 269(3), 1261-7.