As part of the Masereeuw group, Manoe Janssen focusses on understanding pathways that can be pharmacologically triggered to enhance the repair and regeneration of the kidney. She focusses on genetic factors and gene mutations that affect proximal tubule function and the development of human in vitro cell models for drug screening. She makes use of the unique, patented, human renal cell lines from the Masereeuw group who have a high predictive value for drug and waste product transport and metabolism. She compares cells from heathy controls and patients to understand which pathways in the cell are affected, to search for druggable targets and evaluate phenotypic improvements. As part of an international consortium on the genetic kidney disease cystinosis she is testing different drug compounds as well as CRISPR/Cas9 mediated gene repair to find a new therapy for this disease.