We know there is a temporal relation between late-life depression and dementia. The causal mechanism behind it is unclear. In this project we will examine the two leading hypotheses: glucocorticoid cascade hypothesis and the cardiovascular risk hypothesis. We will do this by using longitudinal data from two large cohorts of older people (AGES and SMART study).
Together with Karolinska Institute (department of Medical Epidemiology and Biostatistics) we investigate effects of psychosocial factors on biomarkers of aging
Combining genetics and stress to predict the onset of depression and examine to which extent brain is affected by stress and depression
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