dr. E.J. (Eefjan) Breukink
E.J.Breukink@uu.nl
Gegenereerd op 2017-06-27 09:18:24


Alle publicaties
  2017 - Wetenschappelijke publicaties
Calvez, Philippe, Breukink, Eefjan, Roper, David I, Dib, Mélanie, Contreras-Martel, Carlos & Zapun, André (06-01-2017). Substitutions in PBP2b from β-lactam resistant Streptococcus pneumoniae have different effects on enzymatic activity and drug reactivity. Journal of Biological Chemistry, 292 (7), (pp. 2854-2865) (12 p.). Copyright © 2017, The American Society for Biochemistry and Molecular Biology..
  2016 - Wetenschappelijke publicaties
Oppedijk, Sabine F., Martin, Nathaniel I. & Breukink, Eefjan (2016). Hit 'em where it hurts - The growing and structurally diverse family of peptides that target lipid-II. Biochimica et Biophysica Acta - Biomembranes, 1858 (5), (pp. 947–957).
Liu, Yao, Garcia Lopes Maia Rodrigues, João, Bonvin, Alexandre M J J, Zaal, Esther A., Berkers, Celia R., Heger, Michal, Gawarecka, Katarzyna, Swiezewska, Ewa, Breukink, Eefjan & Egmond, Maarten R. (15-07-2016). New insight into the catalytic mechanism of bacterial mray from enzyme kinetics and docking studies. Journal of Biological Chemistry, 291 (29), (pp. 15057-15068) (12 p.).
't Hart, Peter, Oppedijk, Sabine F, Breukink, Eefjan & Martin, Nathaniel I (2016). New Insights into Nisin's Antibacterial Mechanism Revealed by Binding Studies with Synthetic Lipid II Analogues. Biochemistry, 55 (1), (pp. 232–237).
Van 't Veer, Inge Leonie, Leloup, Nadia, Egan, Alexander, Janssen, Bert, Martin, Nathaniel, Vollmer, Waldemar & Breukink, Eefjan (2016). Site specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface. ChemBioChem, (pp. 1-8) (9 p.). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..
Broekgaarden, M., Van Vught, R., Oliveira, Sabrina, Roovers, R. C., Van Bergen En Henegouwen, P. M P, Pieters, R. J., Van Gulik, T. M., Breukink, E. & Heger, M. (28-03-2016). Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy. Nanoscale, 8 (12), (pp. 6490-6494) (5 p.).
Cleverley, Robert M., Rismondo, Jeanine, Lockhart-Cairns, Michael P., Van Bentum, Paulien T., Egan, Alexander J F, Vollmer, Waldemar, Halbedel, Sven, Baldock, Clair, Breukink, Eefjan & Lewis, Richard J. (01-09-2016). Subunit arrangement in GpsB, a regulator of cell wall biosynthesis. Microbial Drug Resistance, 22 (6), (pp. 446-460) (15 p.).
Kleijn, Laurens H J, Oppedijk, Sabine F., T Hart, Peter, Van Harten, Roel M., Martin-Visscher, Leah A., Kemmink, Johan, Breukink, Eefjan & Martin, Nathaniel I. (11-03-2016). Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action. Journal of Medicinal Chemistry, 59 (7), (pp. 3569-3574) (6 p.).
  2015 - Wetenschappelijke publicaties
Egan, Alexander J F, Biboy, Jacob, van 't Veer, Inge, Breukink, Eefjan & Vollmer, Waldemar (05-10-2015). Activities and regulation of peptidoglycan synthases. Philosophical Transactions of the Royal Society B: Biological Sciences, 370 (1679).
Gray, Andrew N, Egan, Alexander J F, van 't Veer, Inge, Verheul, Jolanda, Colavin, Alexandre, Koumoutsi, Alexandra, Biboy, Jacob, Altelaar, A F Maarten, Damen, Mirjam J, Huang, Kerwyn Casey, Simorre, Jean-Pierre, Breukink, Eefjan, den Blaauwen, Tanneke, Typas, Athanasios, Gross, Carol A & Vollmer, Waldemar (07-05-2015). Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division. eLife, 4.
Blanchaert, Bart, Wyseure, Tine, Breukink, Eefjan, Adams, Erwin, Declerck, Paul & Van Schepdael, Ann (01-11-2015). Development of a liquid chromatography/mass spectrometry assay for the bacterial transglycosylation reaction through measurement of Lipid II. Electrophoresis, 36 (21-22), (pp. 2841-2849) (9 p.).
Weijer, Ruud, Broekgaarden, Mans, Kos, Milan, van Vught, Remko, Rauws, Erik A J, Breukink, Eefjan, van Gulik, Thomas M., Storm, G & Heger, Michal (01-06-2015). Enhancing photodynamic therapy of refractory solid cancers - Combining second-generation photosensitizers with multi-targeted liposomal delivery. Journal of Photochemistry and Photobiology C: Photochemistry Reviews, 23, (pp. 103-131) (29 p.).
Scheidelaar, Stefan, Koorengevel, Martijn C., Pardo, Juan Dominguez, Meeldijk, Johannes D., Breukink, Eefjan & Killian, J. Antoinette (20-01-2015). Molecular Model for the solubilization of membranes into nanodisks by styrene maleic acid copolymers. Biophysical Journal, 108 (2), (pp. 279-290) (12 p.).
Bury, Daniel, Dahmane, Ismahene, Derouaux, Adeline, Dumbre, Shrinivas, Herdewijn, Piet, Matagne, André, Breukink, Eefjan, Mueller-Seitz, Erika, Petz, Michael & Terrak, Mohammed (15-01-2015). Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase. Biochemical Pharmacology, 93 (2), (pp. 141-150) (10 p.).
Koopmans, Timo, Wood, Thomas M., 'T Hart, Peter, Kleijn, Laurens H J, Hendrickx, Antoni P A, Willems, Rob J L, Breukink, Eefjan & Martin, Nathaniel I. (29-07-2015). Semisynthetic Lipopeptides Derived from Nisin Display Antibacterial Activity and Lipid II Binding on Par with That of the Parent Compound. Journal of the American Chemical Society, 137 (29), (pp. 9382-9389) (8 p.).
Sosič, Izidor, Anderluh, Marko, Sova, Matej, Gobec, Martina, Mlinarič Raščan, Irena, Derouaux, Adeline, Amoroso, Ana, Terrak, Mohammed, Breukink, Eefjan & Gobec, Stanislav (03-12-2015). Structure-Activity Relationships of Novel Tryptamine-Based Inhibitors of Bacterial Transglycosylase. Journal of Medicinal Chemistry
Slootweg, Jack C., Van Herwerden, Eric F., Van Doremalen, Mark F M, Breukink, Eefjan, Liskamp, Rob M J & Rijkers, Dirk T S (07-06-2015). Synthesis of nisin AB dicarba analogs using ring-closing metathesis - Influence of sp3versus sp2 hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity. Organic and Biomolecular Chemistry, 13 (21), (pp. 5997-6009) (13 p.).
  2014 - Wetenschappelijke publicaties
Harmsen, Rianne A G, Ghalit, Nourdin, Kemmink, Johan, Breukink, Eefjan, Liskamp, Rob M J & Rijkers, Dirk T S (21-10-2014). A conformationally constrained fused tricyclic nisin AB-ring system mimic toward an improved pyrophosphate binder of lipid II. Tetrahedron, 70 (42), (pp. 7691-7699) (9 p.).
Egan, Alexander J F, Jean, Nicolas L., Koumoutsi, Alexandra, Bougault, Catherine M., Biboy, Jacob, Sassine, Jad, Solovyova, Alexandra S., Breukink, Eefjan, Typas, Athanasios, Vollmer, Waldemar & Simorre, Jean Pierre (03-06-2014). Outer-membrane lipoprotein LpoB spans the periplasm to stimulate the peptidoglycan synthase PBP1B. Proceedings of the National Academy of Sciences of the United States of America, 111 (22), (pp. 8197-8202) (6 p.).
Slootweg, Jack C., Peters, Nienke, Quarles Van Ufford, H. C., Breukink, Eefjan, Liskamp, Rob M J & Rijkers, Dirk T S (01-10-2014). Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment. Bioorganic and Medicinal Chemistry, 22 (19), (pp. 5345-5353) (9 p.).
Van Vught, Remko, Pieters, Roland J. & Breukink, Eefjan (01-01-2014). Site-specific functionalization of proteins and their applications to therapeutic antibodies. Computational and Structural Biotechnology Journal, 9 (14).
Mohammadi, Tamimount, Sijbrandi, Robert, Lutters, Mandy, Verheul, Jolanda, Martin, Nathaniel I, den Blaauwen, Tanneke, de Kruijff, Ben & Breukink, Eefjan (2014). Specificity of the transport of lipid II by FtsW in Escherichia coli. Journal of Biological Chemistry, 289 (21), (pp. 14707-14718) (12 p.). © 2014 by The American Society for Biochemistry and Molecular Biology, Inc..
Mohammadi, Tamimount & Breukink, Eefjan (07-07-2014). The chlamydial anomaly clarified?. ChemBioChem, 15 (10), (pp. 1391-1392) (2 p.).
  2013 - Wetenschappelijke publicaties
Imran, Muhammad, Revol-Junelles, A.-M., Diepeveen-de Bruin, M., Paris, C., Breukink, E.J. & Desobry, S. (2013). Fluorescent labeling of nisin Z and assessment of anti-listerial action. Journal of Microbiological Methods, 95 (2), (pp. 107-113) (7 p.).
Slootweg, J.C., van Schaik, T.B., Quarles van Ufford, H.C., Breukink, E.J., Liskamp, R.M.J. & Rijkers, D.T.S. (2013). Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative. Bioorganic and Medicinal Chemistry Letters, 23, (pp. 3749-3752) (4 p.).
Zapun, A., Philippe, J., Abrahams, K.A., Signor, L., Roper, D.I., Breukink, E.J. & Vernet, T. (2013). In vitro Reconstitution of Peptidoglycan Assembly from the Gram-Positive Pathogen Streptococcus pneumoniae. ACS Chemical Biology, 8 (12), (pp. 2688-2696) (9 p.).
Kindrachuk, J., Jenssen, H., Elliott, M., Breukink, E.J., Hancock, R.E.W. & et al., [No Value] (2013). Manipulation of innate immunity by a bacterial secreted peptide: Lantibiotic nisin Z is selectively immunomodulatory. Innate Immunity, 19 (3), (pp. 315-327) (13 p.). 14 auteurs in totaal.
Slootweg, J.C., van der Wal, S., Quarles van Ufford, H.C., Breukink, E.J., Liskamp, R.M.J. & Rijkers, D.T.S. (2013). Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified conjugates accessed by CuAAC. Bioconjugate Chemistry, 24 (2), (pp. 2058-2066) (9 p.).
Slootweg, Jack C., Van Der Wal, Steffen, Quarles Van Ufford, H. C., Breukink, Eefjan, Liskamp, Rob M J & Rijkers, Dirk T S (18-12-2013). Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC. Bioconjugate Chemistry, 24 (12), (pp. 2058-2066) (9 p.).
Varney, K.M., Bonvin, A.M.J.J., Pazgier, M., Malin, J., Yu, W., Ateh, E., Oashi, T., Lu, W., Huang, J., Diepeveen-de Buin, M., Bryant, J., Breukink, E.J., MacKerell, A.D. & de Leeuw, E.P.H. (2013). Turning Defense into Offense: Development of Defensin Mimetics as Novel Antibiotics targeting Lipid II. PLoS Pathogens, 9 (11), (pp. 1-14) (14 p.).
  2012 - Wetenschappelijke publicaties
Broekgaarden, Mans, Van Vught, Remko, De Kroon, Anton I.P.M., Breukink, Eefjan, Van Gulik, Thomas M. & Heger, Michal (01-03-2012). Assessment of in vitro efficiency of multi-targeting liposomes containing zinc-phthalocyanine for photodynamic therapy. Lasers in Surgery and Medicine, 44, (pp. 38-39) (2 p.).
Nikolaidis, Ioulia, Izoré, Thierry, Job, Viviana, Thielens, Nicole, Breukink, Eefjan & Dessen, Andréa (2012). Calcium-dependent complex formation between PBP2 and lytic transglycosylase SltB1 of Pseudomonas aeruginosa. Microbial Drug Resistance, 18 (3), (pp. 298-305) (8 p.).
Banzhaf, Manuel, van den Berg van Saparoea, Bart, Terrak, Mohammed, Fraipont, Claudine, Egan, Alexander, Philippe, Jules, Zapun, André, Breukink, Eefjan, Nguyen-Distèche, Martine, den Blaauwen, Tanneke & Vollmer, Waldemar (2012). Cooperativity of peptidoglycan synthases active in bacterial cell elongation. Molecular Microbiology, 85 (1), (pp. 179-194) (16 p.). © 2012 Blackwell Publishing Ltd..
Arnusch, C.J., Pieters, R.J. & Breukink, E.J. (2012). Enhanced membrane pore formation through high-affinity targeted antimicrobial peptides. PLoS One, 7, (pp. e39768) (1 p.).
Chamorro Perez, M.C., Boerman, M.A., Arnusch, C.J., Breukink, E.J. & Pieters, R.J. (2012). Enhancing membrane disruption by targeting and multivalent presentation of antimicrobial peptides. Biochimica et Biophysica Acta - Biomembranes, 1818, (pp. 2171-2174) (4 p.).
Paiva, Aline Dias, Irving, Nicole, Breukink, Eefjan & Mantovani, Hilário Cuquetto (2012). Interaction with lipid II induces conformational changes in bovicin HC5 structure. Antimicrobial Agents and Chemotherapy, 56 (9), (pp. 4586-4593) (8 p.).
Mulder, Monique P. C., Fodran, Peter, Kemmink, Johan, Breukink, Eefjan J., Kruijtzer, John A. W., Minnaard, Adriaan J. & Liskamp, Rob M. J. (07-10-2012). Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin. Organic and Biomolecular Chemistry, 10 (37), (pp. 7491-7502) (12 p.).
Mulder, M.P.C., Fodran, P., Kemmink, J., Breukink, E.J., Kruijtzer, J.A.W., Minnaard, A.J. & Liskamp, R.M.J. (2012). Mutual influence of backbone proline substitution and lipopholic tail character on the biological activity of simplified analogues of caspofungin. Organic and Biomolecular Chemistry, 10, (pp. 7491-7502) (12 p.).
Te Welscher, Yvonne Maria, Van Leeuwen, Martin Richard, De Kruijff, Ben, Dijksterhuis, Jan & Breukink, Eefjan (10-07-2012). Polyene antibiotic that inhibits membrane transport proteins. Proceedings of the National Academy of Sciences of the United States of America, 109 (28), (pp. 11156-11159) (4 p.).
van der Kaaden, M., Breukink, E.J. & Pieters, R.J. (2012). Synthesis and antifungal properties of papulacandin derivatives. Beilstein Journal of Organic Chemistry, 8, (pp. 732-737) (6 p.).
Helassa, Nordine, Vollmer, Waldemar, Breukink, Eefjan, Vernet, Thierry & Zapun, André (2012). The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length. The FEBS journal, 279 (11), (pp. 2071-81) (11 p.). © 2012 The Authors Journal compilation © 2012 FEBS..
Paiva, Aline Dias, de Oliveira, Michelle Dias, de Paula, Sérgio Oliveira, Baracat-Pereira, Maria Cristina, Breukink, Eefjan & Mantovani, Hilário Cuquetto (2012). Toxicity of bovicin HC5 against mammalian cell lines and the role of cholesterol in bacteriocin activity. Microbiology, 158 (Pt 11), (pp. 2851-8) (8 p.).
  2011 - Wetenschappelijke publicaties
Olrichs, Nick K., Aarsman, Mirjam E.G., Verheul, Jolanda, Arnusch, Christopher J., Martin, Nathaniel I., Hervé, Mireille, Vollmer, Waldemar, de Kruijff, Ben, Breukink, Eefjan & den Blaauwen, Tanneke (2011). A Novel in vivo Cell-Wall Labeling Approach Sheds New Light on Peptidoglycan Synthesis in Escherichia coli. ChemBioChem, 12 (7), (pp. 1124-1133) (10 p.).
Olrichs, N.K., Aarsman, M.E.G., Verheul, J,, Arnusch, C.J., Martin, N.I., Herve, M., Vollmer, W., de Kruijff, B., Breukink, E.J. & den Blaauwen, T.A. (2011). A novel in vivo cell-wall labelling approach sheds new light on peptidoglycan synthesis in Escherichia coli. ChemBioChem, 12, (pp. 1124-1133) (10 p.).
Mohammadi, Tamimount, Van Dam, Vincent, Sijbrandi, Robert, Vernet, Thierry, Zapun, André, Bouhss, Ahmed, Diepeveen-De Bruin, Marlies, Nguyen-Distéche, Martine, De Kruijff, Ben & Breukink, Eefjan (20-04-2011). Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane. EMBO Journal, 30 (8), (pp. 1425-1432) (8 p.).
Wijnker, J.J., Weerts, E.A.W.S., Breukink, E.J., Houben, J.H. & Lipman, L.J.A. (2011). Reduction of Clostridium sporogenes spore outgrowth in natural sausage casings using nisin. Food Microbiology, 28 (5), (pp. 974-979) (6 p.).
Paiva, Aline Dias, Breukink, Eefjan & Mantovani, Hilário Cuquetto (2011). Role of lipid II and membrane thickness in the mechanism of action of the lantibiotic bovicin HC5. Antimicrobial Agents and Chemotherapy, 55 (11), (pp. 5284-5293) (10 p.).
Derouaux, Adeline, Turk, Samo, Olrichs, Nick K, Gobec, Stanislav, Breukink, Eefjan, Amoroso, Ana, Offant, Julien, Bostock, Julieanne, Mariner, Katherine, Chopra, Ian, Vernet, Thierry, Zervosen, Astrid, Joris, Bernard, Frère, Jean-Marie, Nguyen-Distèche, Martine & Terrak, Mohammed (2011). Small molecule inhibitors of peptidoglycan synthesis targeting the lipid II precursor. Biochemical Pharmacology, 81 (9), (pp. 1098-105) (8 p.). Copyright © 2011 Elsevier Inc. All rights reserved..
Mulder, M.P.C., Kruijtzer, J.A.W., Breukink, E.J., Kemmink, J., Pieters, R.J. & Liskamp, R.M.J. (2011). Synthesis and evaluation of novel macrocyclic antifungal peptides. Bioorganic and Medicinal Chemistry, 19, (pp. 6505-6517) (13 p.).
  2010 - Wetenschappelijke publicaties
de Leeuw, E.P.H., Li, C., Zeng, P., Li, Chong, Diepeveen-de Bruin, M., Lu, W.Y., Breukink, E.J. & Lu, W. (2010). Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II. FEBS Letters, 584 (8), (pp. 1543-1548) (6 p.).
te Welscher, Y.M., Jones, L., van Leeuwen, M.R., Dijksterhuis, J., de Kruijff, B., Eitzen, G. & Breukink, E.J. (2010). Natamycin inhibits vacuole fusion at the priming phase via a specific interaction with ergosterol. Antimicrobial Agents and Chemotherapy, 54 (6), (pp. 2618-2625) (8 p.).
Offant, J., Terrak, Mohammed, Derouaux, Adeline, Breukink, E.J., Nguyen-Distèche, Martine, Zapun, A. & Vernet, T. (2010). Optimization of conditions for the glycosyltransferase activity of penicillin-binding protein 1a from Thermotoga maritima. The FEBS journal, 277 (20), (pp. 4290-4298) (9 p.).
van den Besselaar, A.M.H.P., Breukink, E.J. & Koorengevel, M.C. (2010). Phosphatidylglycerol and daptomycin synergistically inhibit tissue factor-induced coagulation in the prothrombin time test. Journal of Thrombosis and Haemostasis, 8 (6), (pp. 1429-1430) (2 p.). No abstract is available for this article.
Typas, Athanasios, Banzhaf, Manuel, van den Berg van Saparoea, Bart, Verheul, Jolanda, Biboy, Jacob, Nichols, Robert J, Zietek, Matylda, Beilharz, Katrin, Kannenberg, Kai, von Rechenberg, Moritz, Breukink, Eefjan, den Blaauwen, Tanneke, Gross, Carol A & Vollmer, Waldemar (23-12-2010). Regulation of peptidoglycan synthesis by outer-membrane proteins. Cell, 143 (7), (pp. 1097-109) (13 p.). Copyright © 2010 Elsevier Inc. All rights reserved..
  2009 - Wetenschappelijke publicaties
Strianese, M., Zauner, G., Tepper, A.W.J.W., Bubacco, L., Breukink, E.J., Aartsma, J., Canters, G.W. & Tabares, L.C. (2009). A protein-based oxygen biosensor for high-throughput monitoring of cell growth and cell viability. Analytical Biochemistry, 385 (2), (pp. 242-248) (7 p.).
Breukink, E.J. (2009). Lethal traffic jam. Science, 325, (pp. 684-685) (2 p.).
Pieters, R.J., Arnusch, C.J. & Breukink, E.J. (2009). Membrane permeabilization by multivalent anti-microbial peptides. Protein and Peptide Letters, 16, (pp. 736-742) (7 p.).
Albada, H.B., Arnusch, C.J., Branderhorst, H.M., Verel, A.M., Janssen, W.T.M., Breukink, E.J., de Kruijff, B., Pieters, R.J. & Liskamp, R.M.J. (2009). Potential scorpionate antibiotics: targeted hydrolysis of lipid II containing model membranes by vancomycin-TACzyme conjugates and modulation of their antibacterial activity by Zn-ions. Bioorganic and Medicinal Chemistry Letters, 19, (pp. 3721-3724) (4 p.).
van Dam, V., Olrichs, N.K. & Breukink, E.J. (2009). Specific labeling of peptidoglycan precursors as a tool for bacterial cell wall studies. ChemBioChem, 10 (4), (pp. 617-624) (8 p.).
  2008 - Wetenschappelijke publicaties
Smith, L., Hasper, H.E., Breukink, E.J., Čerkasov, J., Hillman, J.D., Wilson-Stanford, S. & Orugunty, R.S. (2008). Elucidation of the antimicrobial mechanism of mutacin 1140. Biochemistry, 47 (10), (pp. 3308-3314) (7 p.).
Terrak, M., Sauvage, E., Derouaux, A., Dehareng, D., Bouhss, A., Breukink, E.J., Jeanjean, S. & Nguyen-Distèche, M. (2008). Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli. Journal of Biological Chemistry, 283 (42), (pp. 28464-28470) (7 p.).
Kramer, N.E., Hasper, H.E., van den Bogaard, P.T.C., Morath, S., de Kruijff, B., Hartung, T., Smid, E.J., Breukink, E.J., Kok, J. & Kuipers, O.P. (2008). Increased D-alanylation of lipoteichoic acid and a thickened septum are main determinants in the nisin resistance mechanism of Lactococcus lactis. Microbiology, 154, (pp. 1755-1762) (8 p.).
de Kruijff, B., van Dam, V. & Breukink, E.J. (2008). Lipid II:a central component in bacterial cell wall synthesis and a target for antibiotics. Prostaglandins Leukotrienes and Essential Fatty Acids, 79, (pp. 117-121) (5 p.).
Parisot, Judicaël, Carey, Sarah, Breukink, E.J., Chan, W.C., Narbad, A. & Bonev, B.B. (2008). Molecular mechanism of target recognition by Subtilin, a class I Lanthionine antibiotic. Antimicrobial Agents and Chemotherapy, 52 (2), (pp. 612-618) (7 p.).
te Welscher, Y.M., ten Napel, H.H., Masià Balagué, M., Souza, C.M., Riezman, H., de Kruijff, B. & Breukink, E.J. (2008). Natamycin blocks fungal growth by binding specifically to ergosterol without permeabilizing the membrane. Journal of Biological Chemistry, 283 (10), (pp. 6393-6401) (9 p.).
Derouaux, Adeline, Wolf, Benoît, Fraipont, Claudine, Breukink, E.J., Nguyen-Distèche, Martine & Terrak, Mohammed (2008). The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with the penicillin-binding protein 3 (PBP3), FtsW and FtsN. Journal of Bacteriology, 190 (5), (pp. 1831-1834) (4 p.).
Arnusch, C.J., Bonvin, A.M.J.J., Verel, A.M., Jansen, W.T.M., Liskamp, R.M.J., de Kruijff, B., Pieters, R.J. & Breukink, E.J. (2008). The vancomycin-nisin(1-12) hybrid restores activity against vancomycin resistant enterococci. Biochemistry, 47 (48), (pp. 12661-12663) (3 p.).
  2007 - Wetenschappelijke publicaties
Hasegawa, M., Kawasaki, A., Yang, K., Fujimoto, Y., Masumoto, J., Breukink, E.J., Nuñez, G., Fukase, K. & Inohara, N. (2007). A role of lipophilic peptidoglycan-related molecules in induction of Nod1-mediated immune responses. Journal of Biological Chemistry, 282 (16), (pp. 11757-11764) (8 p.).
Arnusch, C.J., Branderhorst, H.M., de Kruijff, B., Liskamp, R.M.J., Breukink, E.J. & Pieters, R.J. (2007). Enhanced membrane pore information by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46, (pp. 13437-13442) (6 p.).
Ghalit, N., Reichwein, J.F., Hilbers, H.W., Breukink, E.J., Rijkers, D.T.S. & Liskamp, R.M.J. (2007). Synthesis of bicyclic alkene/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as Lipid II binders: toward the design of potential novel antibiotics. ChemBioChem, 8, (pp. 1540-1554) (15 p.).
Müller, Patrick, Ewers, C., Bertsche, U., Anstett, M., Kallis, T., Breukink, E.J., Fraipont, Claudine, Terrak, Mohammed, Nguyen-Distèche, Martine & Vollmer, W. (2007). The essential cell division protein FtsN interacts with the murein (peptidoglycan) synthase PBP1B in Escherichia coli. Journal of Biological Chemistry, 282 (50), (pp. 36394-36402) (9 p.).
Martin, N.I. & Breukink, E.J. (2007). The expanding role of lipid II as a target for lantibiotics. Future Microbiology, 2, (pp. 513-525) (13 p.).
van Dam, V., Sijbrandi, R., Kol, M.A., Swiezewska, E., de Kruijff, B. & Breukink, E.J. (2007). Transmembrane transport of peptidoglycan precursors across model and bacterial membranes. Molecular Microbiology, 64 (4), (pp. 1105-1114) (10 p.).
  2006 - Wetenschappelijke publicaties
Breukink, E.J. (2006). A lesson in efficient killing from two-component lantibiotics. Molecular Microbiology, 61, (pp. 271-273) (3 p.).
Hasper, H.E., Kramer, N.E., Smith, J.L., Hillman, J.D., Zachariah, C., Kuipers, O.P., de Kruijff, B. & Breukink, E.J. (2006). An alternative bactericidal mechanism of action for lantibiotic peptides that target Lipid II. Science, 313, (pp. 1636-1637) (2 p.).
Born, P., Breukink, E.J. & Vollmer, W. (2006). In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli. Journal of Biological Chemistry, 281, (pp. 26985-26993) (9 p.).
Breukink, E.J. & de Kruijff, B. (2006). Lipid II as a target for antibiotics. Nature Reviews Drug Discovery, 5, (pp. 321-332) (12 p.).
Ganchev, D.N., Hasper, H.E., Breukink, E.J. & de Kruijff, B. (2006). Size and orientation of the Lipid II head group as revealed by AFM imaging. Biochemistry, 45, (pp. 6195-6202) (8 p.).
Hsu, S.T., Breukink, E.J. & Kaptein, R. (2006). Structural motifs of lipid II-binding lantibiotics as a blueprint for novel antibiotics. Anti-Infective Agents in Medicinal Chemistry, 5 (3), (pp. 245-254) (10 p.).
  2006 - Populariserende publicaties
Breukink, Eefjan (27-06-2006). Nieuw wapen tegen resistentie. Pharmaceutisch Weekblad, 141 (26), (pp. 886-887) (2 p.).
  2005 - Wetenschappelijke publicaties
Bertsche, U., Breukink, E.J., Kast, T. & Volmer, W. (2005). In vitro murein (peptidoglycan) synthesis by dimers of the bifunctional transglycosylase-transpeptidase PBP1B from Escherichia coli. Journal of Biological Chemistry, 280, (pp. 38096-38101) (6 p.).
  2004 - Wetenschappelijke publicaties
Hasper, Hester Emilie, De Kruijff, Ben & Breukink, Eefjan (14-09-2004). Assembly and stability of nisin-Lipid II pores. Biochemistry, 43 (36), (pp. 11567-11575) (9 p.).
Hasper, H.E., de Kruijff, B. & Breukink, E.J. (2004). Assembly and stability of nisin-lipid pores. Biochemistry, 43, (pp. 11567-11575) (9 p.).
Kramer, N.E., Smid, E.J., Kok, J., de Kruijff, B., Kuipers, O.P. & Breukink, E.J. (2004). Resistance of Gram-positive bacteria to nisin is not determined by Lipid II levels. FEMS Microbiology Letters, 239, (pp. 157-161) (5 p.).
Bonev, B.B., Breukink, E.J., Swiezewska, E., de Kruijff, B. & Watts, A. (2004). Targeting extracellular pyrophosphates underpins the high selectivity of nisin. FASEB Journal, 18, (pp. 1862-1869) (18 p.).
Hsu, S.T., Breukink, E.J., Tischenko, E., Lutters, M.A.G., de Kruijff, B., Kaptein, R., Bonvin, A.M.J.J. & van Nuland, N.A.J. (2004). The nisin-lipid complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics. Nature Structural and Molecular Biology, 11, (pp. 963-967) (5 p.).
Hsu, Shang-Te D., Breukink, Eefjan, Tischenko, Eugene, Lutters, Mandy A. G., De Kruijff, Ben, Kaptein, R, Bonvin, Alexandre M. J. J. & Van Nuland, Nico A. J. (01-10-2004). The nisin-lipid II complex reveals a pyrophosphate cage that provides a blueprint for novel antibiotics. Nature Structural and Molecular Biology, 11 (10), (pp. 963-967) (5 p.).
  2003 - Wetenschappelijke publicaties
Bonnici, P.J., Breukink, E.J. & Heck, A.J.R. (2003). Getting closer to the real bacterial cell wall target: biomolecular interactions of water-soluble lipid II with glycopeptide antibiotics. Chemistry-A European Journal, 9, (pp. 1556-1565) (10 p.).
Breukink, E.J., van Heusden, H.E., Bonnici, P.J., Swiezewska, E., Brunner, L., Walker, S.M., Heck, A.J.R. & de Kruijff, B. (2003). Lipid II is an intrinsic component of the pore induced by nisin in bacterial membranes. Journal of Biological Chemistry, 278, (pp. 19898-19903) (6 p.).
Kleinnijenhuis, A.J., Duursma, M.C., Breukink, E.J., Heeren, R.M.A. & Heck, A.J.R. (2003). Localization of intramolecular monosulfide bridges in lantibiotics determined with electron capture induced dissociation. Analytical Chemistry, 75, (pp. 3219-3225) (7 p.).
van den Brink - van der Laan, E., Boots, J.W.P., Spelbrink, R.E.J., Kool, G.M., Breukink, E.J., Killian, J.A. & de Kruijff, B. (2003). Membrane interaction of the glycolsyltransferase MurG: a special role for cardiolipin. Journal of Bacteriology, 185, (pp. 3773-3779) (7 p.).
Hsu, S.T., Breukink, E.J., Bierbaum, G., Sahl, H.-G., de Kruijff, B., Kaptein, R., van Nuland, N.A.J. & Bonvin, A.M.J.J. (2003). NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles. Journal of Biological Chemistry, 278, (pp. 13110-13117) (8 p.).
Hsu, Shang-Te D., Breukink, Eefjan, Bierbaum, Gabriele, Sahl, Hans-Georg, De Kruijff, Ben, Kaptein, R, Van Nuland, Nico A. J. & Bonvin, Alexandre M. J. J. (11-04-2003). NMR study of mersacidin and lipid II interaction in dodecylphosphocholine micelles: Conformational changes are a key to antimicrobial activity. Journal of Biological Chemistry, 278 (15), (pp. 13110-13117) (8 p.).
  2002 - Wetenschappelijke publicaties
Hsu, S., Breukink, E.J., de Kruijff, B., Kaptein, R., Bonvin, A.M.J.J. & van Nuland, N.A.J. (2002). Mapping the targeted membrane pore formation mechanism by solution NMR: the nisin Z and lipid II interaction in SDS micelles. Biochemistry, 41, (pp. 7670-7676) (7 p.).
  2001 - Wetenschappelijke publicaties
Heck, A.J.R., Bonnici, P.J., Breukink, E.J., Morris, D. & Wills, M. (2001). Modification and inhibition of vancomycin group antibiotics by formaldehyde and acetaldehyde. Chemistry-A European Journal, 7, (pp. 910-916) (7 p.).
Wiedemann, I., Breukink, E.J., van Kraaij, C., Kuipers, O.P., Bierbaum, G., de Kruijff, B. & Sahl, H.-G. (2001). Specific binding of nisin to the peptidoglycan precursor lipid II combines pore formation and inhibition of cell wall biosynthesis for potent antibiotic activity. Journal of Biological Chemistry, 276, (pp. 1772-1779) (9 p.).
  1999 - Wetenschappelijke publicaties
Lins, L., Ducarme, P., Breukink, E. & Brasseur, R. (20-08-1999). Computational study of nisin interaction with model membrane. Biochimica et Biophysica Acta - Biomembranes, 1420 (1-2), (pp. 111-120) (10 p.).
Breukink, E., Wiedemann, I., Van Kraaij, C., Kuipers, O.P., Sahl, H.-G. & De Kruijff, B. (17-12-1999). Use of the cell wail precursor lipid II by a pore-forming peptide antibiotic. Science, 286 (5448), (pp. 2361-2364) (4 p.).
  1998 - Wetenschappelijke publicaties
Breukink, Eefjan, Van Kraaij, Cindy, Van Dalen, Annemieke, Demel, Rudy A., Siezen, Roland J., De Kruijff, Ben & Kuipers, Oscar P. (02-06-1998). The orientation of nisin in membranes. Biochemistry, 37 (22), (pp. 8153-8162) (10 p.).
  1997 - Wetenschappelijke publicaties
Den Blaauwen, Tanneke, De Wit, Janny G., Gosker, Harry, Van Der Does, Chris, Breukink, Eef-Jan, De Leij, Lou & Driessen, Arnold J. M. (29-07-1997). Inhibition of preprotein translocation and reversion of the membrane inserted state of SecA by a carboxyl terminus binding MAb. Biochemistry, 36 (30), (pp. 9159-9168) (10 p.).
Breukink, Eefjan, Van Kraaij, Cindy, Demel, Rudy A., Siezen, Roland J., Kuipers, Oscar P. & De Kruijff, Ben (10-06-1997). The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane. Biochemistry, 36 (23), (pp. 6968-6976) (9 p.).
  1996 - Wetenschappelijke publicaties
Van Raalte, Anne L. J., Demel, Rudy A., Verberkmoes, Geerten, Breukink, Eefjan, Keller, Rob C. A. & De Kruijff, Ben (09-01-1996). Influence of the signal sequence and chaperone SecB on the interaction between precursor protein prePhoE and phospholipids. Biochemistry International, 235 (1-2), (pp. 207-214) (8 p.).
  1995 - Wetenschappelijke publicaties
Breukink, Eefjan, Nouwen, Nico, Van Raalte, Anne, Mizushima, Shoji, Tommassen, Jan & De Kruijff, Ben (07-04-1995). The C terminus of SecA is involved in both lipid binding and SecB binding. Journal of Biological Chemistry, 270 (14), (pp. 7902-7907) (6 p.).
  1994 - Wetenschappelijke publicaties
Kusters, Ron, Breukink, Eefjan, Gallusser, Andreas, Kuhn, Andreas & De Kruijff, Ben (14-01-1994). A dual role for phosphatidylglycerol in protein translocation across the Escherichia coli inner membrane. Journal of Biological Chemistry, 269 (2), (pp. 1560-1563) (4 p.).
  1993 - Wetenschappelijke publicaties
Breukink, E., Keller, R.C.A. & De Kruijff, B. (09-01-1993). Nucleotide and negatively charged lipid-dependent vesicle aggregation caused by SecA. Evidence that SecA contains two lipid-binding sites. FEBS Letters, 331 (1-2), (pp. 19-24) (6 p.).
  1992 - Wetenschappelijke publicaties
Breukink, E., Kusters, R. & De Kruijff, B. (09-01-1992). In-vitro studies on the folding characteristics of the Escherichia coli precursor protein prePhoE. Evidence that SecB prevents the precursor from aggregating by forming A functional complex. Biochemistry International, 208 (2), (pp. 419-425) (7 p.).
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