Bardiot, D., Vangeel, L., Koukni, M., Arzel, P., Zwaagstra, M., Lyoo, H., Wanningen, P., Ahmad, S., Zhang, L., Sun, X., Delpal, A., Eydoux, C., Guillemot, J-C., Lescrinier, E., Klaassen, H., Leyssen, P., Jochmans, D., Castermans, K., Hilgenfeld, R., ... Marchand, A. (2022). Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication. Molecules (Basel, Switzerland), 27(3), 1-26. [1052]. https://doi.org/10.3390/molecules27031052

Hurdiss, D. L., El Kazzi, P., Bauer, L., Papageorgiou, N., Ferron, F. P., Donselaar, T., Van Vliet, A. L. W., Shamorkina, T. M., Snijder, J., Canard, B., Decroly, E., Brancale, A., Zeev-Ben-Mordehai, T., Förster, F., Van Kuppeveld, F. J. M., & Coutard, B. (2022). Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex. Science advances, 8(1), [abj7615]. https://doi.org/10.1126/sciadv.abj7615

Langereis, M. A., Albulescu, I. C., Stammen-Vogelzangs, J., Lambregts, M., Stachura, K., Miller, S., Bosco-Lauth, A. M., Hartwig, A. E., Porter, S. M., Allen, M., Mogler, M., van Kuppeveld, F. J. M., Bosch, B-J., Vermeij, P., de Groof, A., Bowen, R. A., Davis, R., Xu, Z., & Tarpey, I. (2021). An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats. npj Vaccines, 6(1), [122]. https://doi.org/10.1038/s41541-021-00390-9

Fröberg, J., Gillard, J., Philipsen, R., Lanke, K., Rust, J., van Tuijl, D., Teelen, K., Bousema, T., Simonetti, E., van der Gaast-de Jongh, C. E., Bos, M., van Kuppeveld, F. J., Bosch, B-J., Nabuurs-Franssen, M., van der Geest-Blankert, N., van Daal, C., Huynen, M. A., de Jonge, M. I., & Diavatopoulos, D. A. (2021). SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms. Nature Communications, 12(1), 1-11. [5621]. https://doi.org/10.1038/s41467-021-25949-x

Martina, M. G., Vicenti, I., Bauer, L., Crespan, E., Rango, E., Boccuto, A., Olivieri, N., Incerti, M., Zwaagstra, M., Allodi, M., Bertoni, S., Dreassi, E., Zazzi, M., van Kuppeveld, F. J. M., Maga, G., & Radi, M. (2021). Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus and Human Rhinoviruses. ChemMedChem, 16(23), 3548-3552. https://doi.org/10.1002/cmdc.202100483

Ni, Y., Rosier, B. J. H. M., van Aalen, E. A., Hanckmann, E. T. L., Biewenga, L., Pistikou, A-M. M., Timmermans, B., Vu, C., Roos, S., Arts, R., Li, W., de Greef, T. F. A., van Borren, M. M. G. J., van Kuppeveld, F. J. M., Bosch, B-J., & Merkx, M. (2021). A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays. Nature Communications, 12(1), 1-12. [4586]. https://doi.org/10.1038/s41467-021-24874-3

Haagmans, B. L., Noack, D., Okba, N. M. A., Li, W., Wang, C., Bestebroer, T., de Vries, R., Herfst, S., de Meulder, D., Verveer, E., van Run, P., Lamers, M. M., Rijnders, B., Rokx, C., van Kuppeveld, F., Grosveld, F., Drabek, D., GeurtsvanKessel, C., Koopmans, M., ... Rockx, B. (2021). SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model. Journal of Infectious Diseases, 223(12), 2020-2028. https://doi.org/10.1093/infdis/jiab289

Klooster, J. P. T., Bol-Schoenmakers, M., van Summeren, K., van Vliet, A. L. W., de Haan, C. A. M., van Kuppeveld, F. J. M., Verkoeijen, S., & Pieters, R. (2021). Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine. Communications Biology, 4(1), 1-13. [631]. https://doi.org/10.1038/s42003-021-02176-0

Dai, M., Du, W., Martínez-Romero, C., Leenders, T., Wennekes, T., Rimmelzwaan, G. F., van Kuppeveld, F. J. M., Fouchier, R. A. M., Garcia-Sastre, A., de Vries, E., & de Haan, C. A. M. (2021). Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics. mBio, 12(3), 1-18. [e00287-21]. https://doi.org/10.1128/mBio.00287-21

Fedry, J., Hurdiss, D. L., Wang, C., Li, W., Obal, G., Drulyte, I., Du, W., Howes, S. C., van Kuppeveld, F. J. M., Förster, F., & Bosch, B-J. (2021). Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Science advances, 7(23), 1-11. [eabf5632]. https://doi.org/10.1126/sciadv.abf5632

Zhao, S., Schuurman, N., Li, W., Wang, C., Smit, L. A. M., Broens, E. M., Wagenaar, J. A., van Kuppeveld, F. J. M., Bosch, B-J., & Egberink, H. (2021). Serologic Screening of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Cats and Dogs during First Coronavirus Disease Wave, the Netherlands. Emerging Infectious Diseases, 27(5), 1362-1370. https://doi.org/10.3201/eid2705.204055

Wallace, L. E., Liu, M., van Kuppeveld, F., de Vries, E., & de Haan, C. A. M. (2021). Respiratory mucus as a virus-host range determinant. Trends in Microbiology, 29(11), 983-992. https://doi.org/10.1016/j.tim.2021.03.014

Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., Li, W., Okba, N. M. A., Albulescu, I., Widjaja, I., van Dieren, B., Fernandez-Delgado, R., Sola, I., Hurdiss, D. L., Daramola, O., Grosveld, F., van Kuppeveld, F. J. M., Haagmans, B. L., Enjuanes, L., Drabek, D., & Bosch, B-J. (2021). A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies. Nature Communications, 12(1), 1-15. [1715]. https://doi.org/10.1038/s41467-021-21968-w

Amsterdam University Medical Center COVID-19 Biobank Study Group, (2020). Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19. Journal of Immunology, 205(12), 3491-3499. https://doi.org/10.4049/jimmunol.2000767

Du, W., de Vries, E., van Kuppeveld, F. J. M., Matrosovich, M., & de Haan, C. A. M. (2020). Second sialic acid-binding site of influenza A virus neuraminidase: Binding receptors for efficient release. The FEBS journal. https://doi.org/10.1111/febs.15668

Sooksawasdi Na Ayudhya, S., Meijer, A., Bauer, L., Oude Munnink, B., Embregts, C., Leijten, L., Siegers, J. Y., Laksono, B. M., van Kuppeveld, F., Kuiken, T., GeurtsvanKessel, C., & van Riel, D. (2020). Erratum for Sooksawasdi Na Ayudhya et al., "Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1". mSphere, 5(6), 1. [e00941-20]. https://doi.org/10.1128/mSphere.01147-20

Sooksawasdi Na Ayudhya, S., Meijer, A., Bauer, L., Oude Munnink, B., Embregts, C., Leijten, L., Siegers, J. Y., Laksono, B. M., van Kuppeveld, F., Kuiken, T., Geurts-van Kessel, C., van Riel, D., & Lakdawala, S. (2020). Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1. mSphere, 5(6), [e00941-20]. https://doi.org/10.1128/mSphere.00941-20

Bauer, L., Manganaro, R., Zonsics, B., Hurdiss, D. L., Zwaagstra, M., Donselaar, T., Welter, N. G. E., van Kleef, R. G. D. M., Lopez, M. L., Bevilacqua, F., Raman, T., Ferla, S., Bassetto, M., Neyts, J., Strating, J. R. P. M., Westerink, R. H. S., Brancale, A., & van Kuppeveld, F. J. M. (2020). Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C. PLoS Biology, 18(11), [e3000904]. https://doi.org/10.1371/journal.pbio.3000904

Boersma, S., Rabouw, H. H., Bruurs, L. J. M., Pavlovič, T., van Vliet, A. L. W., Beumer, J., Clevers, H., van Kuppeveld, F. J. M., & Tanenbaum, M. E. (2020). Translation and Replication Dynamics of Single RNA Viruses. Cell. https://doi.org/10.1016/j.cell.2020.10.019

Lang, Y., Li, W., Li, Z., Koerhuis, D., van den Burg, A. C. S., Rozemuller, E., Bosch, B-J., van Kuppeveld, F. J. M., Boons, G-J., Huizinga, E. G., van der Schaar, H. M., & de Groot, R. J. (2020). Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity. Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25759-25770. https://doi.org/10.1073/pnas.2006299117

Hurdiss, D. L., Drulyte, I., Lang, Y., Shamorkina, T. M., Pronker, M. F., van Kuppeveld, F. J. M., Snijder, J., & de Groot, R. J. (2020). Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans. Nature Communications, 11(1), 1-10. [4646]. https://doi.org/10.1038/s41467-020-18440-6

Haagmans, B. L., Noack, D., Okba, N. MA., Li, W., Wang, C., de Vries, R., Herfst, S., de Meulder, D., van Run, P., Rijnders, B., Rokx, C., van Kuppeveld, F., Grosveld, F., GeurtsvanKessel, C., Koopmans, M., Jan Bosch, B., Kuiken, T., & Rockx, B. (2020). SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a 1 hamster model 2 3. bioRxiv. https://doi.org/10.1101/2020.08.24.264630

Zhao, S., Schuurman, N., Tieke, M., Quist, B., Zwinkels, S., van Kuppeveld, F., de Haan, C. A. M., & Egberink, H. (Accepted/In press). Serological screening of influenza A virus antibodies in cats and dogs indicates frequent infection with different subtypes. Journal of Clinical Microbiology. https://doi.org/10.1128/JCM.01689-20

Giansanti, P., Strating, J. R. P. M., Defourny, K. A. Y., Cesonyte, I., Bottino, A. M. S., Post, H., Viktorova, E. G., Ho, V. Q. T., Langereis, M. A., Belov, G. A., Nolte-'t Hoen, E. N. M., Heck, A. J. R., & van Kuppeveld, F. J. M. (2020). Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection. Nature Communications, 11(1), 1-12. [4332]. https://doi.org/10.1038/s41467-020-18168-3

Du, W., Wolfert, M. A., Peeters, B., van Kuppeveld, F. J. M., Boons, G-J., de Vries, E., & de Haan, C. A. M. (2020). Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1008816

van den Hoogen, B., Santoni, A., Sciumé, G., Bowie, A., O'Farrelly, C., O'Neill, L., Anthonsen, M., Pardali, K., Young, S., Bergthaler, A., Manel, N., Zahn, R., Kikkert, M., Snijder, E., van Kuppeveld, F., Fouchier, R., & Hiscott, J. (2020). Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network. Virus Research, [198094]. https://doi.org/10.1016/j.virusres.2020.198094

Visser, L. J., Aloise, C., Swatek, K. N., Medina, G. N., Olek, K. M., Rabouw, H. H., de Groot, R. J., Langereis, M. A., de Los Santos, T., Komander, D., Skern, T., & van Kuppeveld, F. J. M. (2020). Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression. PLoS Pathogens, 16(7), [e1008702]. https://doi.org/10.1371/journal.ppat.1008702

Rabouw, H. H., Visser, L. J., Passchier, T. C., Langereis, M. A., Liu, F., Giansanti, P., van Vliet, A. L. W., Dekker, J. G., van der Grein, S. G., Saucedo, J. G., Anand, A. A., Trellet, M. E., Bonvin, A. M. J. J., Walter, P., Heck, A. J. R., de Groot, R. J., & van Kuppeveld, F. J. M. (2020). Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association. Nature Microbiology, 5, 1361-1373. https://doi.org/10.1038/s41564-020-0759-0

Wang, C., Li, W., Drabek, D., Okba, N. M. A., van Haperen, R., Osterhaus, A. D. M. E., van Kuppeveld, F. J. M., Haagmans, B. L., Grosveld, F., & Bosch, B-J. (2020). A human monoclonal antibody blocking SARS-CoV-2 infection. Nature Communications, 11(1), 1-6. [2251]. https://doi.org/10.1038/s41467-020-16256-y

Manganaro, R., Zonsics, B., Bauer, L., Lorenzo Lopez, M., Donselaar, T., Zwaagstra, M., Saporito, F., Ferla, S., Strating, J. R. P. M., Coutard, B., Hurdiss, D. L., van Kuppeveld, F. J. M., & Brancale, A. (2020). Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors. Antiviral Research, [104781]. https://doi.org/10.1016/j.antiviral.2020.104781

Dirmeier, S., Dächert, C., van Hemert, M., Tas, A., Ogando, N. S., van Kuppeveld, F., Bartenschlager, R., Kaderali, L., Binder, M., & Beerenwinkel, N. (2020). Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation. PLoS Computational Biology, 16(2), [e1007587]. https://doi.org/10.1371/journal.pcbi.1007587

Melia, C. E., Peddie, C. J., de Jong, A. W. M., Snijder, E. J., Collinson, L. M., Koster, A. J., van der Schaar, H. M., van Kuppeveld, F. J. M., & Bárcena, M. (2019). Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy. mBio, 10(3). https://doi.org/10.1128/mBio.00951-19

Widjaja, I., Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., van Dieren, B., Okba, N. M. A., Raj, V. S., Li, W., Fernandez-Delgado, R., Grosveld, F., van Kuppeveld, F. J. M., Haagmans, B. L., Enjuanes, L., Drabek, D., & Bosch, B. J. (2019). Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein. Emerging Microbes and Infections, 8(1), 516-530. https://doi.org/10.1080/22221751.2019.1597644

Zhao, S., Smits, C., Schuurman, N., Barnum, S., Pusterla, N., Kuppeveld, F. V., Bosch, B-J., Maanen, K. V., & Egberink, H. (2019). Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus. Viruses, 11(12). https://doi.org/10.3390/v11121109

Bauer, L., Manganaro, R., Zonsics, B., Strating, J. R. P. M., El Kazzi, P., Lorenzo Lopez, M., Ulferts, R., van Hoey, C., Mate, M. J., Langer, T., Coutard, B., Brancale, A., & van Kuppeveld, F. J. M. (2019). Fluoxetine inhibits enterovirus replication by targeting the viral 2C protein in a stereospecific manner. ACS Infect Dis, 5(9), 1609-1623. https://doi.org/10.1021/acsinfecdis.9b00179

Schuster, S., Overheul, G. J., Bauer, L., van Kuppeveld, F. J. M., & van Rij, R. P. (2019). No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells. Scientific Reports, 9(1), [13752]. https://doi.org/10.1038/s41598-019-50287-w

Baggen, J., Liu, Y., Lyoo, H., van Vliet, A. L. W., Wahedi, M., de Bruin, J. W., Roberts, R. W., Overduin, P., Meijer, A., Rossmann, M. G., Thibaut, H. J., & van Kuppeveld, F. J. M. (2019). Bypassing pan-enterovirus host factor PLA2G16. Nature Communications, 10(1), [3171]. https://doi.org/10.1038/s41467-019-11256-z

Sun, L., Tijsma, A., Mirabelli, C., Baggen, J., Wahedi, M., Franco, D., De Palma, A., Leyssen, P., Verbeken, E., van Kuppeveld, F. J. M., Neyts, J., & Thibaut, H. J. (2019). Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence. Emerging Microbes and Infections, 8(1), 1076-1085. https://doi.org/10.1080/22221751.2019.1644142

Baggen, J., Thibaut, H. J., Hurdiss, D. L., Wahedi, M., Marceau, C. D., van Vliet, A. L. W., Carette, J. E., & van Kuppeveld, F. J. M. (2019). Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus. mBio, 10(4), [e01780-19]. https://doi.org/10.1128/mBio.01780-19

Zhao, S., Li, W., Schuurman, N., van Kuppeveld, F., Bosch, B-J., & Egberink, H. (2019). Serological Screening for Coronavirus Infections in Cats. Viruses, 11(8), [743]. https://doi.org/10.3390/v11080743

Belov, G. A., & van Kuppeveld, F. J. M. (2019). Lipid Droplets Grease Enterovirus Replication. Cell Host & Microbe, 26(2), 149-151. https://doi.org/10.1016/j.chom.2019.07.017

Horova, V., Lyoo, H., Różycki, B., Chalupska, D., Smola, M., Humpolickova, J., Strating, J. R. P. M., van Kuppeveld, F. J. M., Boura, E., & Klima, M. (2019). Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites. PLoS Pathogens, 15(8), [e1007962]. https://doi.org/10.1371/journal.ppat.1007962

McPhail, J. A., Lyoo, H. R., Pemberton, J. G., Hoffmann, R. M., Elst, W. V., Strating, J. R. P. M., Jenkins, M. L., Stariha, J. T. B., Kuppeveld, F. J. M. V., Balla, T., & Burke, J. E. (2019). Characterization of the Golgi c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication. EMBO Reports, [e48441]. https://doi.org/10.15252/embr.201948441

Du, W., Guo, H., Nijman, V. S., Doedt, J., van der Vries, E., van der Lee, J., Li, Z., Boons, G-J., van Kuppeveld, F. J. M., de Vries, E., Matrosovich, M., & de Haan, C. A. M. (2019). The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathogens, 15(6), [e1007860]. https://doi.org/10.1371/journal.ppat.1007860

Visser, L. J., Langereis, M. A., Rabouw, H. H., Wahedi, M., Muntjewerff, E. M., de Groot, R. J., & van Kuppeveld, F. J. M. (2019). Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I interferon. Journal of Virology, 93(10), [e00222-19]. https://doi.org/10.1128/JVI.00222-19

van der Grein, S. G., Defourny, K. A. Y., Rabouw, H. H., Galiveti, C. R., Langereis, M. A., Wauben, M. H. M., Arkesteijn, G. J. A., van Kuppeveld, F. J. M., & Nolte-'t Hoen, E. N. M. (2019). Picornavirus infection induces temporal release of multiple extracellular vesicle subsets that differ in molecular composition and infectious potential. PLoS Pathogens, 15(2), [e1007594]. https://doi.org/10.1371/journal.ppat.1007594

Lyoo, H., van der Schaar, H. M., Dorobantu, C. M., Rabouw, H. H., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2019). ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB. mBio, 10(1), [e02742-18]. https://doi.org/10.1128/mBio.02742-18

Rabouw, H. H., Langereis, M. A., Anand, A. A., Visser, L. J., de Groot, R. J., Walter, P., & van Kuppeveld, F. J. M. (2019). Small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proceedings of the National Academy of Sciences of the United States of America, 116(6), 2097-2102. https://doi.org/10.1073/pnas.1815767116

Hulswit, R. J. G., Lang, Y., Bakkers, M. J. G., Li, W., Li, Z., Schouten, A., Ophorst, B., van Kuppeveld, F. J. M., Boons, G-J., Bosch, B-J., Huizinga, E. G., & de Groot, R. J. (2019). Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A. Proceedings of the National Academy of Sciences of the United States of America, 116(7), 2681-2690. https://doi.org/10.1073/pnas.1809667116

Visser, L. J., Medina, G. N., Rabouw, H. H., de Groot, R. J., Langereis, M. A., de Los Santos, T., & van Kuppeveld, F. J. M. (2019). FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation. Journal of Virology, 93(2), [e00922-18]. https://doi.org/10.1128/JVI.00922-18

Ma, Y., Cong, W., Huang, H., Sun, L., Mai, A. H., Boonen, K., Maryam, W., De Borggraeve, W., Luo, G., Liu, Q., Schoofs, L., Van Kuppeveld, F., Neyts, J., Mirabelli, C., & Luyten, W. (2019). Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. International Journal of Antimicrobial Agents, 53(2), 128-136. https://doi.org/10.1016/j.ijantimicag.2018.07.014

Liu, Y., Sheng, J., van Vliet, A. L. W., Buda, G., van Kuppeveld, F. J. M., & Rossmann, M. G. (2018). Molecular basis for the acid-initiated uncoating of human enterovirus D68. Proceedings of the National Academy of Sciences of the United States of America, 115(52), E12209-E12217. https://doi.org/10.1073/pnas.1803347115

Du, W., Dai, M., Li, Z., Boons, G-J., Peeters, B., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2018). Substrate binding by the 2 sialic acid-binding site of influenza A virus N1 neuraminidase contributes to enzymatic activity. Journal of Virology, 92(20), [e01243-18]. https://doi.org/10.1128/JVI.01243-18

Guo, H., Rabouw, H., Slomp, A., Dai, M., van der Vegt, F., van Lent, J. W. M., McBride, R., Paulson, J. C., de Groot, R. J., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2018). Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces. PLoS Pathogens, 14(8), [e1007233]. https://doi.org/10.1371/journal.ppat.1007233

Koestner, W., Spanier, J., Klause, T., Tegtmeyer, P-K., Becker, J., Herder, V., Borst, K., Todt, D., Lienenklaus, S., Gerhauser, I., Detje, C. N., Geffers, R., Langereis, M. A., Vondran, F. W. R., Yuan, Q., van Kuppeveld, F. J. M., Ott, M., Staeheli, P., Steinmann, E., ... Kalinke, U. (2018). Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice. PLoS Pathogens, 14(8), [e1007235]. https://doi.org/10.1371/journal.ppat.1007235

Meutiawati, F., Bezemer, B., Strating, J. R. P. M., Overheul, G. J., Žusinaite, E., van Kuppeveld, F. J. M., van Cleef, K. W. R., & van Rij, R. P. (2018). Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein. Antiviral Research, 157, 68-79. https://doi.org/10.1016/j.antiviral.2018.06.017

Bauer, L., Ferla, S., Head, S. A., Bhat, S., Pasunooti, K. K., Shi, W. Q., Albulescu, L., Liu, J. O., Brancale, A., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2018). Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP). Antiviral Research, 156, 55-63. https://doi.org/10.1016/j.antiviral.2018.05.010

Li, W., Hulswit, R. J. G., Kenney, S. P., Widjaja, I., Jung, K., Alhamo, M. A., van Dieren, B., van Kuppeveld, F. J. M., Saif, L. J., & Bosch, B-J. (2018). Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility. Proceedings of the National Academy of Sciences of the United States of America, 115(22), e5135-e5143. https://doi.org/10.1073/pnas.1802879115

Melia, C. E., van der Schaar, H. M., de Jong, A. W. M., Lyoo, H. R., Snijder, E. J., Koster, A. J., van Kuppeveld, F. J. M., & Bárcena, M. (2018). The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles. mBio, 9(2), [e00420-18]. https://doi.org/10.1128/mBio.00420-18

Baggen, J., Jan Thibaut, H., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2018). The life cycle of non-polio enteroviruses and how to target it. Nature Reviews Microbiology, 16(6), 368-381. https://doi.org/10.1038/s41579-018-0005-4

Swatek, K. N., Aumayr, M., Pruneda, J. N., Visser, L. J., Berryman, S., Kueck, A. F., Geurink, P. P., Ovaa, H., van Kuppeveld, F. J. M., Tuthill, T. J., Skern, T., & Komander, D. (2018). Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proceedings of the National Academy of Sciences of the United States of America, 115(10), 2371-2376. https://doi.org/10.1073/pnas.1710617115

Baggen, J., Hurdiss, D. L., Zocher, G., Mistry, N., Roberts, R. W., Slager, J. J., Guo, H., van Vliet, A. L. W., Wahedi, M., Benschop, K., Duizer, E., de Haan, C. A. M., de Vries, E., Casasnovas, J. M., de Groot, R. J., Arnberg, N., Stehle, T., Ranson, N. A., Thibaut, H. J., & van Kuppeveld, F. J. M. (2018). Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus. Proceedings of the National Academy of Sciences of the United States of America, 115(2), 397-402. https://doi.org/10.1073/pnas.1713284115

Schuster, S., Tholen, L. E., Overheul, G. J., van Kuppeveld, F. J. M., & van Rij, R. P. (2017). Deletion of Cytoplasmic Double-Stranded RNA Sensors Does Not Uncover Viral Small Interfering RNA Production in Human Cells. mSphere, 2(4), [e00333-17]. https://doi.org/10.1128/mSphere.00333-17

Lyoo, H., Dorobantu, C. M., van der Schaar, H. M., & van Kuppeveld, F. J. M. (2017). Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein. Antiviral Research, 147, 86-90. https://doi.org/10.1016/j.antiviral.2017.10.006

Melia, C. E., van der Schaar, H. M., Lyoo, H., Limpens, R. W. A. L., Feng, Q., Wahedi, M., Overheul, G. J., van Rij, R. P., Snijder, E. J., Koster, A. J., Bárcena, M., & van Kuppeveld, F. J. M. (2017). Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles. Cell Reports, 21(3), 587-599. https://doi.org/10.1016/j.celrep.2017.09.068

Li, W., Hulswit, R. J. G., Widjaja, I., Raj, V. S., McBride, R., Peng, W., Widagdo, W., Tortorici, M. A., van Dieren, B., Lang, Y., van Lent, J. W. M., Paulson, J. C., de Haan, C. A. M., de Groot, R. J., van Kuppeveld, F. J. M., Haagmans, B. L., & Bosch, B-J. (2017). Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 114(40), E8508-E8517. https://doi.org/10.1073/pnas.1712592114

Bauer, L., Lyoo, H., van der Schaar, H. M., Strating, J. R., & van Kuppeveld, F. J. (2017). Direct-acting antivirals and host-targeting strategies to combat enterovirus infections. Current Opinion in Virology, 24, 1-8. https://doi.org/10.1016/j.coviro.2017.03.009

Li, W., Luo, R., He, Q., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B-J. (2017). Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus Research, 235, 6-13. https://doi.org/10.1016/j.virusres.2017.03.018

Bakkers, M. J. G., Lang, Y., Feitsma, L. J., Hulswit, R. J. G., de Poot, S. A. H., van Vliet, A. L. W., Margine, I., de Groot-Mijnes, J. D. F., van Kuppeveld, F. J. M., Langereis, M. A., Huizinga, E. G., & de Groot, R. J. (2017). Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity. Cell Host and Microbe, 21(3), 356-366. https://doi.org/10.1016/j.chom.2017.02.008

Strating, J. R., & van Kuppeveld, F. J. (2017). Viral rewiring of cellular lipid metabolism to create membranous replication compartments. Current Opinion in Cell Biology, 47, 24-33. https://doi.org/10.1016/j.ceb.2017.02.005

Dai, M., McBride, R., Dortmans, J. C. F. M., Peng, W., Bakkers, M. J. G., de Groot, R. J., van Kuppeveld, F. J. M., Paulson, J. C., de Vries, E., & de Haan, C. A. M. (2017). Mutation of the 2(nd) Sialic Acid-Binding Site Resulting in Reduced Neuraminidase Activity Preceded Emergence of H7N9 Influenza A Virus. Journal of Virology, 91(9), [e00049-17]. https://doi.org/10.1128/JVI.00049-17

Kindler, E., Gil-Cruz, C., Spanier, J., Li, Y., Wilhelm, J., Rabouw, H. H., Züst, R., Hwang, M., V'kovski, P., Stalder, H., Marti, S., Habjan, M., Cervantes-Barragan, L., Elliot, R., Karl, N., Gaughan, C., van Kuppeveld, F. J. M., Silverman, R. H., Keller, M., ... Thiel, V. (2017). Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS Pathogens, 13(2), [e1006195]. https://doi.org/10.1371/journal.ppat.1006195

Albulescu, L., Bigay, J., Biswas, B., Weber-Boyvat, M., Dorobantu, C. M., Delang, L., van der Schaar, H. M., Jung, Y-S., Neyts, J., Olkkonen, V. M., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2017). Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Research, 140, 37-44. https://doi.org/10.1016/j.antiviral.2017.01.008

Staring, J., von Castelmur, E., Blomen, V. A., van den Hengel, L. G., Brockmann, M., Baggen, J., Thibaut, H. J., Nieuwenhuis, J., Janssen, H., van Kuppeveld, F. J. M., Perrakis, A., Carette, J. E., & Brummelkamp, T. R. (2017). PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature, 541, 412-416. [21032]. https://doi.org/10.1038/nature21032

Guo, H., de Vries, E., McBride, R., Dekkers, J., Bouwman, K. M., Nycholat, C., Verheije, M. H., Paulson, J. C., van Kuppeveld, F. J. M., & de Haan, C. A. M. (2017). Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Emerging Infectious Diseases, 23(2). https://doi.org/10.3201/eid2302.161072

Domsgen, E., Lind, K., Kong, L., Hühn, M. H., Rasool, O., van Kuppeveld, F., Korsgren, O., Lahesmaa, R., & Flodström-Tullberg, M. (2016). An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets. Scientific Reports, 6, [39378]. https://doi.org/10.1038/srep39378

Rabouw, H. H., Langereis, M. A., Knaap, R. C. M., Dalebout, T. J., Canton, J., Sola, I., Enjuanes, L., Bredenbeek, P. J., Kikkert, M., de Groot, R. J., & van Kuppeveld, F. J. M. (2016). Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses. PLoS Pathogens, 12(10), 1-26. [e1005982]. https://doi.org/10.1371/journal.ppat.1005982

Nagy, P. D., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2016). Building Viral Replication Organelles: Close Encounters of the Membrane Types. PLoS Pathogens, 12(10), 1-6. [1005912]. https://doi.org/10.1371/journal.ppat.1005912

Mauthe, M., Langereis, M., Jung, J., Zhou, X., Jones, A., Omta, W., Tooze, S. A., Stork, B., Paludan, S. R., Ahola, T., Egan, D., Behrends, C., Mokry, M., de Haan, X., van Kuppeveld, F., & Reggiori, F. (2016). An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication. Journal of Cell Biology, 214(5), 619-635. https://doi.org/10.1083/jcb.201602046

Dai, M., Guo, H., Dortmans, J., Dekkers, J., Nordholm, J., Daniels, R., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2016). Identification of residues that affect oligomerization and/or enzymatic activity of influenza virus H5N1 neuraminidase proteins. Journal of Virology, 90(20), 9457-9470. https://doi.org/10.1128/JVI.01346-16

Dorobantu, C. M., Harak, C., Klein, R., van der Linden, L., Strating, J. R. P. M., van der Schaar, H. M., Lohmann, V., & van Kuppeveld, F. J. M. (2016). Tyrphostin AG1478 inhibits encephalomyocarditis virus and hepatitis C virus by targeting phosphatidylinositol 4-kinase IIIα. Antimicrobial Agents and Chemotherapy, 60(10), 6402-6406. https://doi.org/10.1128/AAC.01331-16

van der Schaar, H. M., Melia, C. E., van Bruggen, J. A. C., Strating, J. R. P. M., van Geenen, M. E. D., Koster, A. J., Bárcena, M., & van Kuppeveld, F. J. M. (2016). Illuminating the Sites of Enterovirus Replication in Living Cells by Using a Split-GFP-Tagged Viral Protein. mSphere, 1(4), 1-17. [e00104-16]. https://doi.org/10.1128/mSphere.00104-16

Kint, J., Langereis, M. A., Maier, H. J., Britton, P., van Kuppeveld, F. J., Koumans, J., Wiegertjes, G. F., & Forlenza, M. (2016). Infectious bronchitis coronavirus limits interferon production by inducing a host shutoff that requires accessory protein 5b. Journal of Virology, 90(16), 7519-7528. https://doi.org/10.1128/JVI.00627-16

Mullapudi, E., Nováček, J., Pálková, L., Kulich, P., Lindberg, A. M., van Kuppeveld, F. J. M., & Plevka, P. (2016). Structure and genome release mechanism of human cardiovirus Saffold virus-3. Journal of Virology, 90(17), 7628-7639. https://doi.org/10.1128/JVI.00746-16

Dorobantu, C. M., Albulescu, L., Lyoo, H., van Kampen, M., De Francesco, R., Lohmann, V., Harak, C., van der Schaar, H. M., Strating, J. R. P. M., Gorbalenya, A. E., & van Kuppeveld, F. J. M. (2016). Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein. mSphere, 1(3), [ e00068-16]. https://doi.org/10.1128/mSphere.00068-16

Li, W., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B-J. (2016). Cellular entry of the porcine epidemic diarrhea virus. Virus Research, 226, 117-127. https://doi.org/10.1016/j.virusres.2016.05.031

Bakkers, M. J. G., Zeng, Q., Feitsma, L. J., Hulswit, R. J. G., Li, Z., Westerbeke, A., van Kuppeveld, F. J. M., Boons, G-J., Langereis, M. A., Huizinga, E. G., & de Groot, R. J. (2016). Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation. Proceedings of the National Academy of Sciences of the United States of America, 113(22), E3111-E3119. https://doi.org/10.1073/pnas.1519881113

van der Schaar, H. M., Dorobantu, C. M., Albulescu, L., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2016). Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles. Trends in Microbiology, 24(7), 535-546. https://doi.org/10.1016/j.tim.2016.02.017

Arts, P., van de Veerdonk, F. L., van der Lee, R., Langereis, M. A., Gilissen, C., van Zelst-Stams, W. A. G., Huynen, M. A., van der Meer, J. W. M., van Kuppeveld, F. J., Veltman, J. A., Kullberg, B. J., Hoischen, A., & Netea, M. G. (2016). Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy. Journal of Allergy and Clinical Immunology, 138(3), 895-898. https://doi.org/10.1016/j.jaci.2016.02.025

Humoud, M. N., Doyle, N., Royall, E., Willcocks, M. M., Sorgeloos, F., van Kuppeveld, F., Roberts, L. O., Goodfellow, I. G., Langereis, M. A., & Locker, N. (2016). Feline Calicivirus infection disrupts the assembly of cytoplasmic stress granules and induces G3BP1 cleavage. Journal of Virology, 90(14), 6489-6501. https://doi.org/10.1128/JVI.00647-16

Widjaja, I., Wicht, O., Luytjes, W., Leenhouts, K., Rottier, P. J. M., van Kuppeveld, F. J. M., Haijema, B. J., & de Haan, C. A. M. (2016). Characterization of epitope-specific anti-RSV antibody responses after natural infection and after vaccination with formalin-inactivated RSV. Journal of Virology, 90(13), 5965-5977. https://doi.org/10.1128/JVI.00235-16

Lardinois, C., Sorgeloos, F., Jacobs, S., van Kuppeveld, F. J. M., Kaspers, B., & Michiels, T. (2016). Neurotropism of Saffold virus in a mouse model. Journal of General Virology, 97, 1350-1355. https://doi.org/10.1099/jgv.0.000452

Ulferts, R., de Boer, M., van der Linden, L., Bauer, L., Lyoo, H. R., Maté, M. J., Lichière, J., Canard, B., Lelieveld, D., Omta, W., Egan, D., Coutard, B., & van Kuppeveld, F. J. M. (2016). Screening of a library of FDA-approved drugs identifies several enterovirus replicaton inhibitors that target viral protein 2C. Antimicrobial Agents and Chemotherapy, 60(5), 2627-2638. https://doi.org/10.1128/AAC.02182-15

Baglio, S. R., van Eijndhoven, M. A. J., Koppers-Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Léveillé, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., Verkuijlen, S. A. W. M., Scheffer, G. L., van Kuppeveld, F. J. M., de Gruijl, T. D., Bultink, I. E. M., Jordanova, E. S., Hackenberg, M., Piersma, S. R., Knol, J. C., ... Pegtel, D. M. (2016). Sensing of latent EBV infection through exosomal transfer of 5'pppRNA. Proceedings of the National Academy of Sciences of the United States of America, 113(5), E587-E597. https://doi.org/10.1073/pnas.1518130113

Baggen, J., Thibaut, H. J., Staring, J., Jae, L. T., Liu, Y., Guo, H., Slager, J. J., de Bruin, J. W., van Vliet, A. L. W., Blomen, V. A., Overduin, P., Sheng, J., de Haan, X., de Vries, E., Meijer, A., Rossmann, M. G., Brummelkamp, T. R., & van Kuppeveld, F. J. M. (2016). Enterovirus D68 receptor requirements unveiled by haploid genetics. Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1399-1404. https://doi.org/10.1073/pnas.1524498113

Liu, Y., Sheng, J., Baggen, J., Meng, G., Xiao, C., Thibaut, H. J., van Kuppeveld, F. J. M., & Rossmann, M. G. (2015). Sialic acid-dependent cell entry of human enterovirus D68. Nature Communications [E], 6, [8865]. https://doi.org/10.1038/ncomms9865

Kang, H., Kim, C., Kim, D-E., Song, J-H., Choi, M., Choi, K., Kang, M., Lee, K., Kim, H. S., Shin, J. S., Kim, J., Han, S-B., Lee, M-Y., Lee, S. U., Lee, C-K., Kim, M., Ko, H-J., van Kuppeveld, F. J. M., & Cho, S. (2015). Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses. Antiviral Research, 124, 1-10. https://doi.org/10.1016/j.antiviral.2015.10.011

van der Lee, R., Feng, Q., Langereis, M. A., Ter Horst, R., Szklarczyk, R., Netea, M. G., Andeweg, A. C., van Kuppeveld, F. J. M., & Huynen, M. A. (2015). Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response. PLoS Computational Biology, 11(10), [e1004553]. https://doi.org/10.1371/journal.pcbi.1004553

Dorobantu, C. M., Albulescu, L., Harak, C., Feng, Q., van Kampen, M., Strating, J. R. P. M., Gorbalenya, A. E., Lohmann, V., van der Schaar, H. M., & van Kuppeveld, F. J. M. (2015). Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. PLoS Pathogens, 11(9), [e1005185]. https://doi.org/10.1371/journal.ppat.1005185

Sun, L., Meijer, A., Froeyen, M., Zhang, L., Thibaut, H. J., Baggen, J., George, S., Vernachio, J., van Kuppeveld, F. J. M., Leyssen, P., Hilgenfeld, R., Neyts, J., & Delang, L. (2015). Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68. Antimicrobial Agents and Chemotherapy, 59(12), 7782-7785. https://doi.org/10.1128/AAC.01375-15

Langereis, M. A., Rabouw, H. H., Holwerda, M., Visser, L. J., & van Kuppeveld, F. J. M. (2015). cGAS and STING knockout rescues virus infection of plasmid DNA-transfected cells. Journal of Virology, 89(21), 11169-11173. https://doi.org/10.1128/JVI.01781-15

Cancellieri, M., Bassetto, M., Widjaja, I., van Kuppeveld, F., de Haan, C. A. M., Brancale, A., & de Haan, C. A. M. (2015). In silico structure-based design and synthesis of novel anti-RSV compounds. Antiviral Research, 122, 46-50. https://doi.org/10.1016/j.antiviral.2015.08.003

Linden, L. V. D., Wolthers, K. C., & van Kuppeveld, F. J. M. (2015). Replication and Inhibitors of Enteroviruses and Parechoviruses. Viruses [E], 7(8), 4529-4562. https://doi.org/10.3390/v7082832

Widjaja, I., Rigter, A., Jacobino, S., van Kuppeveld, F. J. M., Leenhouts, K., Palomo, C., Melero, J. A., Leusen, J. H. W., Haijema, B. J., Rottier, P. J. M., & de Haan, C. A. M. (2015). Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics. PLoS One, 10(6), [e0130829]. https://doi.org/10.1371/journal.pone.0130829

Langereis, M. A., Bakkers, M. J. G., Deng, L., Padler-Karavani, V., Vervoort, S. J., Hulswit, R. J. G., van Vliet, A. L. W., Gerwig, G. J., de Poot, S. A. H., Boot, W., van Ederen, A. M., Heesters, B. A., van der Loos, C. M., van Kuppeveld, F. J. M., Yu, H., Huizinga, E. G., Chen, X., Varki, A., Kamerling, J. P., & de Groot, R. J. (2015). Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Reports [E], 11(12), 1966-1978. https://doi.org/10.1016/j.celrep.2015.05.044

Li, W., Wicht, O., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B-J. (2015). A single point mutation creating a furin cleavage site in the spike protein renders porcine epidemic diarrhea coronavirus trypsin-independent for cell entry and fusion. Journal of Virology, 89(15), 8077-8081. https://doi.org/10.1128/JVI.00356-15

de Vries, E., Guo, H., Dai, M., Rottier, P. J. M., van Kuppeveld, F. J. M., & de Haan, C. A. M. (2015). Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant. Emerging Infectious Diseases, 21(5), 842-846. https://doi.org/10.3201/eid2105.141927

Schulte, B. M., Gielen, P. R., Kers-Rebel, E. D., Schreibelt, G., van Kuppeveld, F. J. M., & Adema, G. J. (2015). Enterovirus-Infected β-Cells Induce Distinct Response Patterns in BDCA1+ and BDCA3+ Human Dendritic Cells. PLoS One, 10(3), [e0121670]. https://doi.org/10.1371/journal.pone.0121670

Reineke, L. C., Kedersha, N., Langereis, M. A., van Kuppeveld, F. J. M., & Lloyd, R. E. (2015). Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1. MBio [E], 6(2), [e02486-14 ]. https://doi.org/10.1128/mBio.02486-14

van der Linden, L., Vives-Adrián, L., Selisko, B., Ferrer-Orta, C., Liu, X., Lanke, K., Ulferts, R., De Palma, A. M., Tanchis, F., Goris, N., Lefebvre, D., De Clercq, K., Leyssen, P., Lacroix, C., Pürstinger, G., Coutard, B., Canard, B., Boehr, D. D., Arnold, J. J., ... van Kuppeveld, F. J. M. (2015). The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. PLoS Pathogens, 11(3), [e1004733]. https://doi.org/10.1371/journal.ppat.1004733

Albulescu, L., Strating, J. R. P. M., Thibaut, H. J., van der Linden, L., Shair, M. D., Neyts, J., & van Kuppeveld, F. J. M. (2015). Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP. Antiviral Research, 117, 110-114. https://doi.org/10.1016/j.antiviral.2015.02.013

Helms, B., Kaloyanova, D. V., Strating, J. R. P., van Hellemond, J. J., van der Schaar, H. M., Tielens, A. G. M., van Kuppeveld, F. J. M., & Brouwers, J. F. (2015). Targeting of the hydrophobic metabolome by pathogens. Traffic, 16(5), 439-460. https://doi.org/10.1111/tra.12280

Albulescu, L., Wubbolts, R., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2015). Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus. Cellular Microbiology, 17(8), 1144-1156. https://doi.org/10.1111/cmi.12425

Burkard, C., Verheije, M. H., Haagmans, B. L., van Kuppeveld, F. J., Rottier, P. J. M., Bosch, B-J., & de Haan, C. A. M. (2015). ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. Journal of Virology, 89(8), 4434-4448. https://doi.org/10.1128/JVI.03274-14

Strating, J. R. P. M., van der Linden, L., Albulescu, L., Bigay, J., Arita, M., Delang, L., Leyssen, P., van der Schaar, H. M., Lanke, K. H. W., Thibaut, H. J., Ulferts, R., Drin, G., Schlinck, N., Wubbolts, R. W., Sever, N., Head, S. A., Liu, J. O., Beachy, P. A., De Matteis, M. A., ... van Kuppeveld, F. J. M. (2015). Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein. Cell Reports [E], 10(4), 600-615. https://doi.org/10.1016/j.celrep.2014.12.054

Thibaut, H. J., van der Schaar, H. M., Lanke, K. H. W., Verbeken, E., Andrews, M., Leyssen, P., Neyts, J., & van Kuppeveld, F. J. M. (2014). Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta. Journal of Virology, 88(5), 3048-3051. https://doi.org/10.1128/JVI.03177-13

Feng, Q., Langereis, M. A., Lork, M., Nguyen, M., Hato, S. V., Lanke, K., Emdad, L., Bhoopathi, P., Fisher, P. B., Lloyd, R. E., & van Kuppeveld, F. J. M. (2014). Enterovirus 2Apro targets MDA5 and MAVS in infected cells. Journal of Virology, 88(6), 3369-3378. https://doi.org/10.1128/JVI.02712-13

van der Linden, L., Ulferts, R., Nabuurs, S. B., Kusov, Y., Liu, H., George, S., Lacroix, C., Goris, N., Lefebvre, D., Lanke, K. H. W., De Clercq, K., Hilgenfeld, R., Neyts, J., & van Kuppeveld, F. J. M. (2014). Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases. Antiviral Research, 103, 17-24. https://doi.org/10.1016/j.antiviral.2013.12.012

Vives-Adrian, L., Lujan, C., Oliva, B., van der Linden, L., Selisko, B., Coutard, B., Canard, B., van Kuppeveld, F. J. M., Ferrer-Orta, C., & Verdaguer, N. (2014). The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site. Journal of Virology, 88(10), 5595-5607. https://doi.org/10.1128/JVI.03502-13

Deddouche, S., Goubau, D., Rehwinkel, J., Chakravarty, P., Begum, S., Maillard, P. V., Borg, A., Matthews, N., Feng, Q., van Kuppeveld, F. J. M., & Reis e Sousa, C. (2014). Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells. eLife, 3, [e01535]. https://doi.org/10.7554/eLife.01535

Thibaut, H. J., van der Linden, L., Jiang, P., Thys, B., Canela, M-D., Aguado, L., Rombaut, B., Wimmer, E., Paul, A., Pérez-Pérez, M-J., van Kuppeveld, F. J. M., & Neyts, J. (2014). Binding of glutathione to enterovirus capsids is essential for virion morphogenesis. PLoS Pathogens, 10(4), e1004039. https://doi.org/10.1371/journal.ppat.1004039

Feng, Q., Langereis, M. A., Olagnier, D., Chiang, C., van de Winkel, R., van Essen, P., Zoll, J., Hiscott, J., & van Kuppeveld, F. J. M. (2014). Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation. PLoS One, 9(4), e95927. https://doi.org/10.1371/journal.pone.0095927

Feng, Q., Langereis, M. A., & van Kuppeveld, F. J. M. (2014). Induction and suppression of innate antiviral responses by picornaviruses. Cytokine & growth factor reviews, 25(5), 577-585. https://doi.org/10.1016/j.cytogfr.2014.07.003

Galama, J. M. D., Zoll, J. G., Lanke, K. H., de Jong, A. S., Melief, J., Huitinga, I., Verbeek, M. M., & van Kuppeveld, F. J. M. (2014). Saffold cardiovirus and multiple sclerosis: no evidence for an association. Annals of Clinical and Translational Neurology, 1(8), 618-21. https://doi.org/10.1002/acn3.82

Roulin, P. S., Lötzerich, M., Torta, F., Tanner, L. B., van Kuppeveld, F. J. M., Wenk, M. R., & Greber, U. F. (2014). Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. Cell Host & Microbe, 16(5), 677-90. https://doi.org/10.1016/j.chom.2014.10.003

Dorobantu, C. M., Ford-Siltz, L. A., Sittig, S. P., Lanke, K. H. W., Belov, G. A., van Kuppeveld, F. J. M., & van der Schaar, H. M. (2014). GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins. Journal of Virology. https://doi.org/10.1128/JVI.02830-14

Burkard, C., Bloyet, L. M., Wicht, O., Van Kuppeveld, F. J., Rottier, P. J. M., De Haan, C. A. M., & Bosch, B. J. (2014). Dissecting virus entry: Replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase. PLoS One, 9(7), [e101762]. https://doi.org/10.1371/journal.pone.0101762

Dorobantu, C. M., van der Schaar, H. M., Ford, L. A., Strating, J. R. P. M., Ulferts, R., Fang, Y., Belov, G., & van Kuppeveld, F. J. M. (2014). Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1. Journal of Virology, 88(5), 2725-2736. https://doi.org/10.1128/JVI.03650-13

Wicht, O., Burkard, C., de Haan, C. A. M., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell. Journal of Virology, 88(9), 4943-4952. https://doi.org/10.1128/JVI.03451-13

Burkard, C., Verheije, M. H., Wicht, O., van Kasteren, S. I., van Kuppeveld, F. J., Haagmans, B. L., Pelkmans, L., Rottier, P. J. M., Bosch, B. J., & de Haan, C. A. M. (2014). Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner. PLoS Pathogens, 10(11), [e1004502]. https://doi.org/10.1371/journal.ppat.1004502

Wicht, O., Li, W., Willems, L., Meuleman, T. J., Wubbolts, R. W., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture. Journal of Virology, 88(14), 7952-7961. https://doi.org/10.1128/JVI.00297-14

Langereis, M. A., Feng, Q., Nelissen, F. H. T., Virgen-Slane, R., van der Heden van Noort, G. J., Maciejewski, S., Filippov, D. V., Semler, B. L., van Delft, F. L., & van Kuppeveld, F. J. M. (2014). Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA. Nucleic Acids Research, 42(4), 2473-2482. https://doi.org/10.1093/nar/gkt1162

Li, C., Li, Z., Zou, Y., Wicht, O., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2013). Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination. PLoS One, 8(8), [e69997]. https://doi.org/10.1371/journal.pone.0069997

Mou, H., Stalin Raj, V., van Kuppeveld, F. J. M., Rottier, P. J. M., Haagmans, B. L., & Bosch, B. J. (2013). The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies. Journal of Virology, 87(16), 9379-9383. https://doi.org/10.1128/JVI.01277-13

Seehafer, K., Rominger, F., Helmchen, G., Langhans, M., Robinson, D. G., Özata, B., Brügger, B., Strating, J. R. P. M., van Kuppeveld, F. J. M., & Klein, C. D. (2013). Synthesis and Biological Properties of Novel Brefeldin A Analogues. Journal of Medicinal Chemistry, 56(14), 5872-5884. https://doi.org/10.1021/jm400615g

de Vries, R. P., de Vries, E., Martínez-Romero, C., McBride, R., van Kuppeveld, F. J. M., Rottier, P. J. M., García-Sastre, A., Paulson, J. C., & de Haan, C. A. M. (2013). Evolution of the Hemagglutinin Protein of the New Pandemic H1N1 Influenza Virus: Maintaining Optimal Receptor Binding by Compensatory Substitutions. Journal of Virology, 87(24), 13868-13877. https://doi.org/10.1128/JVI.01955-13

Schulte, B. M., Kers-Rebel, E. D., Prosser, A. C., Galama, J. M. D., van Kuppeveld, F. J. M., & Adema, G. J. (2013). Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different enteroviruses. PLoS One, 8(4). https://doi.org/10.1371/journal.pone.0062502

van Cleef, K., Overheul, G., Thomassen, M., Kaptein, S., Davidson, A., Jacobs, M., Neyts, J., van Kuppeveld, F. J. M., & van Rij, R. (2013). Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Research, 99, 165-171.

Dortmans, J. C. F. M., Dekkers, J., Ambepitiya Wickramasinghe, I. N., Verheije, M. H., Rottier, P. J. M., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2013). Adaptation of novel H7N9 influenza A virus to human receptors. Scientific Reports, 3, 3058. https://doi.org/10.1038/srep03058

Triantafilou, K., Kar, S., van Kuppeveld, F. J. M., & Triantafilou, M. (2013). Rhinovirus induced calcium flux triggers NLRP3 and NLRC5 inflammasome activation. American Journal of Respiratory Cell and Molecular Biology, 49(6), 923-934. https://doi.org/10.1165/rcmb.2013-0032OC

van der Schaar, H. M., Leyssen, P., Thibaut, H. J., de Palma, A., van der Linden, L., Lanke, K. H. W., Lacroix, C., Verbeken, E., Conrath, K., Macleod, A. M., Mitchell, D. R., Palmer, N. J., van de Poël, H., Andrews, M., Neyts, J., & van Kuppeveld, F. J. M. (2013). A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ. Antimicrobial Agents and Chemotherapy, 57(10), 4971-4981. https://doi.org/10.1128/AAC.01175-13

Langereis, M. A., Feng, Q., & van Kuppeveld, F. J. M. (2013). MDA5 localizes to stress granules, but this localization is not required for the induction of type I Interferon. Journal of Virology, 87(11), 6314-6325. https://doi.org/10.1128/JVI.03213-12

Strating, J. R. P. M., van der Schaar, H. M., & van Kuppeveld, F. J. M. (2013). Cholesterol: fa(s)t-food for enterovirus genome replication. Trends in Microbiology, 21(11), 560-561. https://doi.org/10.1016/j.tim.2013.09.007

Ulferts, R., Thibaut, H. J., Lanke, K. H. W., Leyssen, P., Coutard, B., De Palma, A. M., Canard, B., Neyts, J., & van Kuppeveld, F. J. M. (2013). Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enterovirus B and D by targeting viral protein 2C. Antimicrobial Agents and Chemotherapy, 57(4), 1952-1956. https://doi.org/10.1128/AAC.02084-12

van Kuppeveld, F. J. M., & van der Meer, J. W. M. (2012). XMRV and CFS--the sad end of a story. The Lancet, 379(9814), e27-8. https://doi.org/10.1016/S0140-6736(11)60899-4

Schulte, B. M., Lanke, K. H. W., Piganelli, J. D., Kers-Rebel, E. D., Bottino, R., Trucco, M., Huijbens, R. J. F., Radstake, T. R. D. J., Engelse, M. A., de Koning, E. J. P., Galama, J. M., Adema, G. J., & van Kuppeveld, F. J. M. (2012). Cytokine and chemokine production by human pancreatic islets upon enterovirus infection. Diabetes, 61(8), 2030-6. https://doi.org/10.2337/db11-1547

Feng, Q., Hato, S. V., Langereis, M. A., Zoll, J., Virgen-Slane, R., Peisley, A., Hur, S., Semler, B. L., van Rij, R. P., & van Kuppeveld, F. J. M. (2012). MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells. Cell Reports [E], 2(5), 1187-1196. https://doi.org/10.1016/j.celrep.2012.10.005

van der Schaar, H. M., van der Linden, L., Lanke, K. H. W., Strating, J. R. P. M., Pürstinger, G., de Vries, E., de Haan, C. A. M., Neyts, J., & van Kuppeveld, F. J. M. (2012). Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication. Cell Research, 22(11), 1576-1592. https://doi.org/10.1038/cr.2012.129

Belov, G. A., & van Kuppeveld, F. J. M. (2012). (+)RNA viruses rewire cellular pathways to build replication. Current Opinion in Virology, 2, 740-747. https://doi.org/10.1016/j.coviro.2012.09.006

Galama, J., Lanke, K., Zoll, J., Roivainen, M., & van Kuppeveld, F. (2011). Seroepidemiology of Saffold cardiovirus type 2. Emerging Infectious Diseases, 17(8), 1572-3. https://doi.org/10.3201/eid1708.101953

Zoll, J., Hahn, M. M., Gielen, P., Heus, H. A., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2011). Unusual loop-sequence flexibility of the proximal RNA replication element in EMCV. PLoS One, 6(9), e24818. https://doi.org/10.1371/journal.pone.0024818

Limpens, R. W. A. L., van der Schaar, H. M., Kumar, D., Koster, A. J., Snijder, E. J., van Kuppeveld, F. J. M., & Bárcena, M. (2011). The transformation of enterovirus replication structures: a three-dimensional study of single- and double-membrane compartments. MBio [E], 2(5). https://doi.org/10.1128/mBio.00166-11

Hato, S. V., Sorgeloos, F., Ricour, C., Zoll, J., Melchers, W. J. G., Michiels, T., & van Kuppeveld, F. J. M. (2010). Differential IFN-alpha/beta production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus. Cellular Microbiology, 12(3), 310-7. https://doi.org/10.1111/j.1462-5822.2009.01395.x

Schulte, B. M., Kramer, M., Ansems, M., Lanke, K. H. W., van Doremalen, N., Piganelli, J. D., Bottino, R., Trucco, M., Galama, J. M. D., Adema, G. J., & van Kuppeveld, F. J. M. (2010). Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes, 59(5), 1182-91. https://doi.org/10.2337/db09-1071

Schulte, B. M., Bakkers, J., Lanke, K. H. W., Melchers, W. J. G., Westerlaken, C., Allebes, W., Aanstoot, H-J., Bruining, G. J., Adema, G. J., Van Kuppeveld, F. J. M., & Galama, J. M. D. (2010). Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection. Viral Immunology, 23(1), 99-104. https://doi.org/10.1089/vim.2009.0072

van Kuppeveld, F. J. M., de Jong, A. S., Lanke, K. H., Verhaegh, G. W., Melchers, W. J. G., Swanink, C. M. A., Bleijenberg, G., Netea, M. G., Galama, J. M. D., & van der Meer, J. W. M. (2010). Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. BMJ - Clinical research, 340, c1018.

Kramer, M., Schulte, B. M., Eleveld-Trancikova, D., van Hout-Kuijer, M., Toonen, L. W. J., Tel, J., de Vries, I. J. M., van Kuppeveld, F. J. M., Jansen, B. J. H., & Adema, G. J. (2010). Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection. Journal of Innate Immunity, 2(4), 360-70. https://doi.org/10.1159/000300568

van der Meer, J. W. M., Netea, M. G., Galama, J. M. D., & van Kuppeveld, F. J. M. (2010). Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome". Science, 328(5980), 825; author reply 825. https://doi.org/10.1126/science.1183906

van der Linden, L., van der Schaar, H. M., Lanke, K. H. W., Neyts, J., & van Kuppeveld, F. J. M. (2010). Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. Journal of Virology, 84(15), 7535-42. https://doi.org/10.1128/JVI.02684-09

Hsu, N-Y., Ilnytska, O., Belov, G., Santiana, M., Chen, Y-H., Takvorian, P. M., Pau, C., van der Schaar, H., Kaushik-Basu, N., Balla, T., Cameron, C. E., Ehrenfeld, E., van Kuppeveld, F. J. M., & Altan-Bonnet, N. (2010). Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell, 141(5), 799-811. https://doi.org/10.1016/j.cell.2010.03.050

Zoll, J., Heus, H. A., van Kuppeveld, F. J. M., & Melchers, W. J. G. (2009). The structure-function relationship of the enterovirus 3'-UTR. Virus Research, 139(2), 209-16. https://doi.org/10.1016/j.virusres.2008.07.014

Krenn, B. M., Gaudernak, E., Holzer, B., Lanke, K., Van Kuppeveld, F. J. M., & Seipelt, J. (2009). Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. Journal of Virology, 83(1), 58-64. https://doi.org/10.1128/JVI.01543-08

Ricour, C., Delhaye, S., Hato, S. V., Olenyik, T. D., Michel, B., van Kuppeveld, F. J. M., Gustin, K. E., & Michiels, T. (2009). Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein. Journal of General Virology, 90(Pt 1), 177-86. https://doi.org/10.1099/vir.0.005678-0

Bardina, M. V., Lidsky, P. V., Sheval, E. V., Fominykh, K. V., van Kuppeveld, F. J. M., Polyakov, V. Y., & Agol, V. I. (2009). Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machinery. Journal of Virology, 83(7), 3150-61. https://doi.org/10.1128/JVI.01456-08

Duijsings, D., Lanke, K. H. W., van Dooren, S. H. J., van Dommelen, M. M. T., Wetzels, R., de Mattia, F., Wessels, E., & van Kuppeveld, F. J. M. (2009). Differential membrane association properties and regulation of class I and class II Arfs. Traffic, 10(3), 316-23. https://doi.org/10.1111/j.1600-0854.2008.00868.x

Zoll, J., Galama, J. M. D., & van Kuppeveld, F. J. M. (2009). Identification of potential recombination breakpoints in human parechoviruses. Journal of Virology, 83(7), 3379-83. https://doi.org/10.1128/JVI.02529-08

De Palma, A. M., Thibaut, H. J., van der Linden, L., Lanke, K., Heggermont, W., Ireland, S., Andrews, R., Arimilli, M., Al-Tel, T. H., De Clercq, E., van Kuppeveld, F., & Neyts, J. (2009). Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrobial Agents and Chemotherapy, 53(5), 1850-7. https://doi.org/10.1128/AAC.00934-08

Zoll, J., Erkens Hulshof, S., Lanke, K., Verduyn Lunel, F., Melchers, W. J. G., Schoondermark-van de Ven, E., Roivainen, M., Galama, J. M. D., & van Kuppeveld, F. J. M. (2009). Saffold virus, a human Theiler's-like cardiovirus, is ubiquitous and causes infection early in life. PLoS Pathogens, 5(5), e1000416. https://doi.org/10.1371/journal.ppat.1000416

Romanova, L. I., Lidsky, P. V., Kolesnikova, M. S., Fominykh, K. V., Gmyl, A. P., Sheval, E. V., Hato, S. V., van Kuppeveld, F. J. M., & Agol, V. I. (2009). Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein. Journal of Virology, 83(14), 7273-84. https://doi.org/10.1128/JVI.00467-09

de Mattia, F., Gubser, C., van Dommelen, M. M. T., Visch, H-J., Distelmaier, F., Postigo, A., Luyten, T., Parys, J. B., de Smedt, H., Smith, G. L., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2009). Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. Molecular Biology of the Cell, 20(16), 3638-45. https://doi.org/10.1091/mbc.E09-05-0385

Lidsky, P. V., Romanova, L. I., Kolesnikova, M. S., Bardina, M. V., Khitrina, E. V., Hato, S. V., van Kuppeveld, F. J. M., & Agol, V. I. (2009). Interactions between viral and prokaryotic pathogens in a mixed infection with cardiovirus and mycoplasma. Journal of Virology, 83(19), 9940-51. https://doi.org/10.1128/JVI.01167-09

Ricour, C., Borghese, F., Sorgeloos, F., Hato, S. V., van Kuppeveld, F. J. M., & Michiels, T. (2009). Random mutagenesis defines a domain of Theiler's virus leader protein that is essential for antagonism of nucleocytoplasmic trafficking and cytokine gene expression. Journal of Virology, 83(21), 11223-32. https://doi.org/10.1128/JVI.00829-09

Lanke, K. H. W., van der Schaar, H. M., Belov, G. A., Feng, Q., Duijsings, D., Jackson, C. L., Ehrenfeld, E., & van Kuppeveld, F. J. M. (2009). GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication. Journal of Virology, 83(22), 11940-9. https://doi.org/10.1128/JVI.01244-09

Kramer, M., Schulte, B. M., Toonen, L. W. J., Barral, P. M., Fisher, P. B., Lanke, K. H. W., Galama, J. M. D., van Kuppeveld, F. J. M., & Adema, G. J. (2008). Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells. Journal of Virology, 82(6), 2930-7. https://doi.org/10.1128/JVI.02376-07

de Jong, A. S., de Mattia, F., Van Dommelen, M. M., Lanke, K., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2008). Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking. Journal of Virology, 82(7), 3782-90. https://doi.org/10.1128/JVI.02076-07

de Vries, W., Haasnoot, J., van der Velden, J., van Montfort, T., Zorgdrager, F., Paxton, W., Cornelissen, M., van Kuppeveld, F., de Haan, P., & Berkhout, B. (2008). Increased virus replication in mammalian cells by blocking intracellular innate defense responses. Gene Therapy, 15(7), 545-52. https://doi.org/10.1038/gt.2008.12

De Palma, A. M., Heggermont, W., Lanke, K., Coutard, B., Bergmann, M., Monforte, A-M., Canard, B., De Clercq, E., Chimirri, A., Pürstinger, G., Rohayem, J., van Kuppeveld, F., & Neyts, J. (2008). The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. Journal of Virology, 82(10), 4720-30. https://doi.org/10.1128/JVI.01338-07

Verheije, M. H., Raaben, M., Mari, M., Te Lintelo, E. G., Reggiori, F., van Kuppeveld, F. J. M., Rottier, P. J. M., & de Haan, C. A. M. (2008). Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. PLoS Pathogens, 4(6), [e1000088]. https://doi.org/10.1371/journal.ppat.1000088

Kramer, M., Schulte, B. M., Toonen, L. W. J., de Bruijni, M. A. M., Galama, J. M. D., Adema, G. J., & van Kuppeveld, F. J. M. (2007). Echovirus infection causes rapid loss-of-function and cell death in human dendritic cells. Cellular Microbiology, 9(6), 1507-18. https://doi.org/10.1111/j.1462-5822.2007.00888.x

Gubser, C., Bergamaschi, D., Hollinshead, M., Lu, X., van Kuppeveld, F. J. M., & Smith, G. L. (2007). A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathogens, 3(2), e17. https://doi.org/10.1371/journal.ppat.0030017

Wessels, E., Duijsings, D., Lanke, K. H. W., Melchers, W. J. G., Jackson, C. L., & van Kuppeveld, F. J. M. (2007). Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1. Journal of Virology, 81(10), 5238-45. https://doi.org/10.1128/JVI.02680-06

Lanke, K., Krenn, B. M., Melchers, W. J. G., Seipelt, J., & van Kuppeveld, F. J. M. (2007). PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells. Journal of General Virology, 88(Pt 4), 1206-17. https://doi.org/10.1099/vir.0.82634-0

Zoll, J., Tessari, M., Van Kuppeveld, F. J. M., Melchers, W. J. G., & Heus, H. A. (2007). Breaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairs. RNA, 13(5), 781-92. https://doi.org/10.1261/rna.375607

Duijsings, D., Wessels, E., van Emst-de Vries, S. E., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2007). Reduction of phospholipase D activity during coxsackievirus infection. Journal of General Virology, 88(Pt 11), 3027-30. https://doi.org/10.1099/vir.0.83169-0

Hato, S. V., Ricour, C., Schulte, B. M., Lanke, K. H. W., de Bruijni, M., Zoll, J., Melchers, W. J. G., Michiels, T., & van Kuppeveld, F. J. M. (2007). The mengovirus leader protein blocks interferon-alpha/beta gene transcription and inhibits activation of interferon regulatory factor 3. Cellular Microbiology, 9(12), 2921-30. https://doi.org/10.1111/j.1462-5822.2007.01006.x

van Ooij, M. J. M., Vogt, D. A., Paul, A., Castro, C., Kuijpers, J., van Kuppeveld, F. J. M., Cameron, C. E., Wimmer, E., Andino, R., & Melchers, W. J. G. (2006). Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. Journal of General Virology, 87(Pt 1), 103-13. https://doi.org/10.1099/vir.0.81297-0

van Ooij, M. J. M., Glaudemans, D. H. R. F., Heus, H. A., van Kuppeveld, F. J. M., & Melchers, W. J. G. (2006). Structural and functional integrity of the coxsackievirus B3 oriR: spacing between coaxial RNA helices. Journal of General Virology, 87(Pt 3), 689-95. https://doi.org/10.1099/vir.0.81558-0

Lidsky, P. V., Hato, S., Bardina, M. V., Aminev, A. G., Palmenberg, A. C., Sheval, E. V., Polyakov, V. Y., van Kuppeveld, F. J. M., & Agol, V. I. (2006). Nucleocytoplasmic traffic disorder induced by cardioviruses. Journal of Virology, 80(6), 2705-17. https://doi.org/10.1128/JVI.80.6.2705-2717.2006

de Jong, A. S., Visch, H-J., de Mattia, F., van Dommelen, M. M., Swarts, H. G., Luyten, T., Callewaert, G., Melchers, W. J., Willems, P. H., & van Kuppeveld, F. J. (2006). The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi. Journal of Biological Chemistry, 281(20), 14144-50. https://doi.org/10.1074/jbc.M511766200

Visch, H-J., Koopman, W. J. H., Zeegers, D., van Emst-de Vries, S. E., van Kuppeveld, F. J. M., van den Heuvel, L. W. P. J., Smeitink, J. A. M., & Willems, P. H. G. M. (2006). Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency. American Journal of Physiology-Cell Physiology, 291(2), C308-16. https://doi.org/10.1152/ajpcell.00561.2005

van Ooij, M. J. M., Polacek, C., Glaudemans, D. H. R. F., Kuijpers, J., van Kuppeveld, F. J. M., Andino, R., Agol, V. I., & Melchers, W. J. G. (2006). Polyadenylation of genomic RNA and initiation of antigenomic RNA in a positive-strand RNA virus are controlled by the same cis-element. Nucleic Acids Research, 34(10), 2953-65. https://doi.org/10.1093/nar/gkl349

Wessels, E., Notebaart, R. A., Duijsings, D., Lanke, K., Vergeer, B., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). Structure-function analysis of the coxsackievirus protein 3A: identification of residues important for dimerization, viral rna replication, and transport inhibition. Journal of Biological Chemistry, 281(38), 28232-43. https://doi.org/10.1074/jbc.M601122200

Wessels, E., Duijsings, D., Lanke, K. H. W., van Dooren, S. H. J., Jackson, C. L., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment. Journal of Virology, 80(23), 11852-60. https://doi.org/10.1128/JVI.01225-06

Wessels, E., Duijsings, D., Niu, T-K., Neumann, S., Oorschot, V. M., de Lange, F., Lanke, K. H. W., Klumperman, J., Henke, A., Jackson, C. L., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1. Developmental Cell, 11(2), 191-201. https://doi.org/10.1016/j.devcel.2006.06.005

van Kuppeveld, F. J. M., de Jong, A. S., Melchers, W. J. G., & Willems, P. H. G. M. (2005). Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive? Trends in Microbiology, 13(2), 41-4. https://doi.org/10.1016/j.tim.2004.12.005

Saelens, X., Festjens, N., Parthoens, E., Vanoverberghe, I., Kalai, M., van Kuppeveld, F., & Vandenabeele, P. (2005). Protein synthesis persists during necrotic cell death. Journal of Cell Biology, 168(4), 545-51. https://doi.org/10.1083/jcb.200407162

Wessels, E., Duijsings, D., Notebaart, R. A., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2005). A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-golgi transport. Journal of Virology, 79(8), 5163-73. https://doi.org/10.1128/JVI.79.8.5163-5173.2005

Krenn, B. M., Holzer, B., Gaudernak, E., Triendl, A., van Kuppeveld, F. J., & Seipelt, J. (2005). Inhibition of polyprotein processing and RNA replication of human rhinovirus by pyrrolidine dithiocarbamate involves metal ions. Journal of Virology, 79(22), 13892-9. https://doi.org/10.1128/JVI.79.22.13892-13899.2005

Bopegamage, S., Kovacova, J., Vargova, A., Motusova, J., Petrovicova, A., Benkovicova, M., Gomolcak, P., Bakkers, J., van Kuppeveld, F., Melchers, W. J. G., & Galama, J. M. (2005). Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection. Journal of General Virology, 86(Pt 12), 3271-80. https://doi.org/10.1099/vir.0.81249-0

Campanella, M., de Jong, A. S., Lanke, K. W. H., Melchers, W. J. G., Willems, P. H. G. M., Pinton, P., Rizzuto, R., & van Kuppeveld, F. J. M. (2004). The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. Journal of Biological Chemistry, 279(18), 18440-50. https://doi.org/10.1074/jbc.M309494200

de Jong, A. S., Melchers, W. J. G., Glaudemans, D. H. R. F., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2004). Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication. Journal of Biological Chemistry, 279(19), 19924-35. https://doi.org/10.1074/jbc.M314094200

de Jong, A. S., Wessels, E., Dijkman, H. B. P. M., Galama, J. M. D., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2003). Determinants for membrane association and permeabilization of the coxsackievirus 2B protein and the identification of the Golgi complex as the target organelle. Journal of Biological Chemistry, 278(2), 1012-21. https://doi.org/10.1074/jbc.M207745200

Lescrinier, E. M. H. P., Tessari, M., van Kuppeveld, F. J. M., Melchers, W. J. G., Hilbers, C. W., & Heus, H. A. (2003). Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs. Journal of Molecular Biology, 331(4), 759-69.

Merkle, I., van Ooij, M. J. M., van Kuppeveld, F. J. M., Glaudemans, D. H. R. F., Galama, J. M. D., Henke, A., Zell, R., & Melchers, W. J. G. (2002). Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region. Journal of Virology, 76(19), 9900-9.

van Kuppeveld, F. J. M., de Jong, A., Dijkman, H. B. P. M., Andino, R., & Melchers, W. J. G. (2002). Studies towards the potential of poliovirus as a vector for the expression of HPV 16 virus-like-particles. FEMS Immunology and Medical Microbiology, 34(3), 201-8.

Zoll, J., Melchers, W. J. G., Galama, J. M. D., & van Kuppeveld, F. J. M. (2002). The mengovirus leader protein suppresses alpha/beta interferon production by inhibition of the iron/ferritin-mediated activation of NF-kappa B. Journal of Virology, 76(19), 9664-72.

van Kuppeveld, F. J. M., Melchers, W. J. G., Willems, P. H. G. M., & Gadella, T. W. J. (2002). Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy. Journal of Virology, 76(18), 9446-56.

de Jong, A. S., Schrama, I. W. J., Willems, P. H. G. M., Galama, J. M. D., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2002). Multimerization reactions of coxsackievirus proteins 2B, 2C and 2BC: a mammalian two-hybrid analysis. Journal of General Virology, 83(Pt 4), 783-93.

van Kuppeveld, F. J. M., van den Hurk, P. J. J. C., Schrama, I. W. J., Galama, J. M. D., & Melchers, W. J. G. (2002). Trans-complementation of a genetic defect in the coxsackie B3 virus 2B protein. Journal of General Virology, 83(Pt 2), 341-50.

Zoll, J., van Kuppeveld, F. J., Galama, J. M., & Melchers, W. J. (1998). Genetic analysis of mengovirus protein 2A: its function in polyprotein processing and virus reproduction. Journal of General Virology, 79 ( Pt 1), 17-25.

Van Horssen, A. M., Van Kuppeveld, F. J., & Martens, G. J. (1998). Manipulation of disulfide bonds differentially affects the intracellular transport, sorting, and processing of neuroendocrine secretory proteins. Journal of Neurochemistry, 71(1), 402-9.

Van kuppeveld, F. J., Melchers, W. J., Kirkegaard, K., & Doedens, J. R. (1997). Structure-function analysis of coxsackie B3 virus protein 2B. Virology, 227(1), 111-8. https://doi.org/10.1006/viro.1996.8320

van Kuppeveld, F. J., Hoenderop, J. G., Smeets, R. L., Willems, P. H., Dijkman, H. B., Galama, J. M., & Melchers, W. J. (1997). Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release. EMBO Journal, 16(12), 3519-32. https://doi.org/10.1093/emboj/16.12.3519

van Kuppeveld, F. J., van den Hurk, P. J., van der Vliet, W., Galama, J. M., & Melchers, W. J. (1997). Chimeric coxsackie B3 virus genomes that express hybrid coxsackievirus-poliovirus 2B proteins: functional dissection of structural domains involved in RNA replication. Journal of General Virology, 78 ( Pt 8), 1833-40.

van Kuppeveld, F. J., van Horssen, A. M., & Martens, G. J. (1997). Intracellular transport, sorting, and proteolytic processing of regulated secretory proteins does not require protein sulfation. Molecular and Cellular Endocrinology, 136(1), 29-35.

van Kuppeveld, F., van der Logt, J., Johansson, K. E., & Melchers, W. (1996). Demonstration of Mycoplasma contamination in cell cultures by a Mycoplasma group- specific polymerase chain reaction. Methods, 2, 525-38. https://doi.org/10.1385/0-89603-335-X:525

van Kuppeveld, F. J., Galama, J. M., Zoll, J., van den Hurk, P. J., & Melchers, W. J. (1996). Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication. Journal of Virology, 70(6), 3876-86.

Zoll, J., Galama, J. M., van Kuppeveld, F. J., & Melchers, W. J. (1996). Mengovirus leader is involved in the inhibition of host cell protein synthesis. Journal of Virology, 70(8), 4948-52.

van Kuppeveld, F. J., van den Hurk, P. J., Zoll, J., Galama, J. M., & Melchers, W. J. (1996). Mutagenesis of the coxsackie B3 virus 2B/2C cleavage site: determinants of processing efficiency and effects on viral replication. Journal of Virology, 70(11), 7632-40.

van Kuppeveld, F. J., Galama, J. M., Zoll, J., & Melchers, W. J. (1995). Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis. Journal of Virology, 69(12), 7782-90.

Tjhie, J. H., van Kuppeveld, F. J., Roosendaal, R., Melchers, W. J., Gordijn, R., MacLaren, D. M., Walboomers, J. M., Meijer, C. J., & van den Brule, A. J. (1994). Direct PCR enables detection of Mycoplasma pneumoniae in patients with respiratory tract infections. Journal of Clinical Microbiology, 32(1), 11-6.

van Kuppeveld, F. J., Johansson, K. E., Galama, J. M., Kissing, J., Bölske, G., van der Logt, J. T., & Melchers, W. J. (1994). Detection of mycoplasma contamination in cell cultures by a mycoplasma group-specific PCR. Applied and Environmental Microbiology, 60(1), 149-52.

van Kuppeveld, F., Melchers, W., Kissing, J., van der Logt, J., & Galama, J. (1994). No evidence of mycoplasmas in peripheral blood mononuclear cell fraction of HIV-infected patients. Infection, 22(3), 204-6.

van Kuppeveld, F. J., Johansson, K. E., Galama, J. M., Kissing, J., Bölske, G., Hjelm, E., van der Logt, J. T., & Melchers, W. J. (1994). 16S rRNA based polymerase chain reaction compared with culture and serological methods for diagnosis of Mycoplasma pneumoniae infection. European Journal of Clinical Microbiology & Infectious Diseases, 13(5), 401-5.

Zoll, J., Jongen, P., Galama, J., van Kuppeveld, F., & Melchers, W. (1993). Coxsackievirus B1-induced murine myositis: no evidence for viral persistence. Journal of General Virology, 74 ( Pt 10), 2071-6.

van Kuppeveld, F. J., Melchers, W. J., Willemse, H. F., Kissing, J., Galama, J. M., & van der Logt, J. T. (1993). Detection of Mycoplasma pulmonis in experimentally infected laboratory rats by 16S rRNA amplification. Journal of Clinical Microbiology, 31(3), 524-7.

van Kuppeveld, F. J., van der Logt, J. T., Angulo, A. F., van Zoest, M. J., Quint, W. G., Niesters, H. G., Galama, J. M., & Melchers, W. J. (1993). Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification. Applied and Environmental Microbiology, 59(2), 655.

van Kuppeveld, F. J., van der Logt, J. T., Angulo, A. F., van Zoest, M. J., Quint, W. G., Niesters, H. G., Galama, J. M., & Melchers, W. J. (1992). Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification. Applied and Environmental Microbiology, 58(8), 2606-15.

Meis, J. F., van Kuppeveld, F. J., Kremer, J. A., Nijhuis, J. G., & Melchers, W. J. (1992). Fatal intrauterine infection associated with Mycoplasma hominis. Clinical Infectious Diseases, 15(4), 753-4.