Prof. dr. F.J.M. (Frank) van Kuppeveld

Prof. dr. F.J.M. (Frank) van Kuppeveld

Professor
Infectious Diseases & Immunology
+31 30 253 4173
f.j.m.vankuppeveld@uu.nl

Publications

2024

Scholarly publications

Pascha, M. N., Ballegeer, M., Roelofs, M. C., Meuris, L., Albulescu, I. C., van Kuppeveld, F. J. M., Hurdiss, D. L., Bosch, B. J., Zeev-Ben-Mordehai, T., Saelens, X., & de Haan, C. A. M. (2024). Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge. npj Vaccines, 9(1), Article 97. https://doi.org/10.1038/s41541-024-00891-3
Defourny, K. A. Y., Pei, X., van Kuppeveld, F. J. M., & Nolte-T Hoen, E. N. M. (2024). Picornavirus security proteins promote the release of extracellular vesicle enclosed viruses via the modulation of host kinases. PLoS Pathogens, 20(4), Article e1012133. https://doi.org/10.1371/journal.ppat.1012133
Luteijn, R. D., & van Kuppeveld, F. J. M. (2024). Author Correction: Rhinoviruses usurp STING for replication. Nature Microbiology. Advance online publication. https://doi.org/10.1038/s41564-024-01689-8
Veth, T. S., Nouwen, L. V., Zwaagstra, M., Lyoo, H., Wierenga, K. A., Westendorp, B., Altelaar, M. A. F. M., Berkers, C., van Kuppeveld, F. J. M., & Heck, A. J. R. (2024). Assessment of Kinome-wide Activity Remodeling Upon Picornavirus Infection. Molecular and Cellular Proteomics, 23(5), Article 100757. https://doi.org/10.1016/j.mcpro.2024.100757
Luteijn, R. D., van Terwisga, S. R., Ver Eecke, J. E., Onia, L., Zaver, S. A., Woodward, J. J., Wubbolts, R. W., Raulet, D. H., & van Kuppeveld, F. J. M. (2024). The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P. Science Signaling, 17(827), Article eade3643. https://doi.org/10.1126/scisignal.ade3643
Nouwen, L. V., Breeuwsma, M., Zaal, E. A., van de Lest, C. H. A., Buitendijk, I., Zwaagstra, M., Balić, P., Filippov, D. V., Berkers, C. R., & van Kuppeveld, F. J. M. (2024). Modulation of nucleotide metabolism by picornaviruses. PLoS Pathogens, 20(3 March), Article e1012036. https://doi.org/10.1371/journal.ppat.1012036
https://dspace.library.uu.nl/bitstream/handle/1874/436825/journal.ppat.1012036.pdf?sequence=1
Pascha, M. N., Ballegeer, M., Roelofs, M. C., Meuris, L., Albulescu, I. C., Kuppeveld, F. J. M. V., Hurdiss, D. L., Bosch, B.-J., Zeev-Ben-Mordehai, T., Saelens, X., & Haan, C. A. M. D. (2024). Nanoparticle display of neuraminidase elicits enhanced antibody responses and protection against influenza A virus challenge in mice. Research Square. https://doi.org/10.21203/rs.3.rs-3579434/v1
https://dspace.library.uu.nl/bitstream/handle/1874/436082/748a8378-0382-43eb-8ee8-d7467ff4d5a6.pdf?sequence=1

2023

Scholarly publications

Bruurs, L. J. M., Müller, M., Schipper, J. G., Rabouw, H. H., Boersma, S., van Kuppeveld, F. J. M., & Tanenbaum, M. E. (2023). Antiviral responses are shaped by heterogeneity in viral replication dynamics. Nature Microbiology, 8(11), 2115-2129. https://doi.org/10.1038/s41564-023-01501-z
Pronker, M. F., Creutznacher, R., Drulyte, I., Hulswit, R. J. G., Li, Z., van Kuppeveld, F. J. M., Snijder, J., Lang, Y., Bosch, B.-J., Boons, G.-J., Frank, M., de Groot, R. J., & Hurdiss, D. L. (2023). Sialoglycan binding triggers spike opening in a human coronavirus. Nature, 624(7990), 201-206. https://doi.org/10.1038/s41586-023-06599-z
https://dspace.library.uu.nl/bitstream/handle/1874/434377/s41586-023-06599-z.pdf?sequence=1
Wallace, L. E., Vries, E. D., Kuppeveld, F. J. M. V., & Haan, C. A. M. D. (2023). Neuraminidase-dependent entry of influenza A virus is determined by hemagglutinin receptor-binding specificity. Journal of Virology, 97(10), Article e0060223. https://doi.org/10.1128/jvi.00602-23
https://dspace.library.uu.nl/bitstream/handle/1874/433046/wallace-et-al-2023-neuraminidase-dependent-entry-of-influenza-a-virus-is-determined-by-hemagglutinin-receptor-binding.pdf?sequence=1
Aloise, C., Schipper, J. G., van Vliet, A., Oymans, J., Donselaar, T., Hurdiss, D. L., de Groot, R. J., & van Kuppeveld, F. J. M. (2023). SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b. PLoS Pathogens, 19(8), Article e1011582. https://doi.org/10.1371/journal.ppat.1011582
Liu, M., Bakker, A. S., Narimatsu, Y., van Kuppeveld, F. J. M., Clausen, H., de Haan, C. A. M., & de Vries, E. (2023). H3N2 influenza A virus gradually adapts to human-type receptor binding and entry specificity after the start of the 1968 pandemic. Proceedings of the National Academy of Sciences of the United States of America, 120(31), Article e2304992120. https://doi.org/10.1073/pnas.2304992120
Duijvestijn, M. B. H. M., Schuurman, N. N. M. P., Vernooij, J. C. M., Leeuwen, M. A. J. M. V., Bosch, B.-J., Brand, J. M. A. V. D., Wagenaar, J. A., Kuppeveld, F. J. M. V., Egberink, H. F., & Verhagen, J. H. (2023). Serological Survey of Retrovirus and Coronavirus Infections, including SARS-CoV-2, in Rural Stray Cats in The Netherlands, 2020–2022. Viruses, 15(7), 1-20. Article 1531. https://doi.org/10.3390/v15071531
Laajala, M., Zwaagstra, M., Martikainen, M., Nekoua, M. P., Benkahla, M., Sane, F., Gervais, E., Campagnola, G., Honkimaa, A., Sioofy-Khojine, A.-B., Hyöty, H., Ojha, R., Bailliot, M., Balistreri, G., Peersen, O., Hober, D., Van Kuppeveld, F., & Marjomäki, V. (2023). Vemurafenib Inhibits Acute and Chronic Enterovirus Infection by Affecting Cellular Kinase Phosphatidylinositol 4-Kinase Type IIIb. Microbiology spectrum, 11(4), 1-19. Article e0055223. https://doi.org/10.1128/spectrum.00552-23
Thijssen, V., Hurdiss, D. L., Debski-Antoniak, O. J., Spence, M. A., Franck, C., Norman, A., Aggarwal, A., Mokiem, N. J., van Dongen, D. A. A., Vermeir, S. W., Liu, M., Li, W., Chatziandreou, M., Donselaar, T., Du, W., Drulyte, I., Bosch, B.-J., Snijder, J., Turville, S. G., ... Jongkees, S. A. K. (2023). A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. Proceedings of the National Academy of Sciences of the United States of America, 120(26), Article e2303292120. https://doi.org/10.1073/pnas.2303292120
Zitzmann, C., Dächert, C., Schmid, B., van der Schaar, H., van Hemert, M., Perelson, A. S., van Kuppeveld, F. J. M., Bartenschlager, R., Binder, M., & Kaderali, L. (2023). Mathematical modeling of plus-strand RNA virus replication to identify broad-spectrum antiviral treatment strategies. PLoS Computational Biology, 19(4), Article e1010423. https://doi.org/10.1371/journal.pcbi.1010423
Liu, M., van Kuppeveld, F. J., de Haan, C. A., & de Vries, E. (2023). Gradual adaptation of animal influenza A viruses to human-type sialic acid receptors. Current Opinion in Virology, 60, 1-15. Article 101314. https://doi.org/10.1016/j.coviro.2023.101314
Wu, X., Goebbels, M., Chao, L., Wennekes, T., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2023). Kinetic analysis of paramyxovirus-sialoglycan receptor interactions reveals virion motility. PLoS Pathogens, 19(3), Article e1011273. https://doi.org/10.1371/journal.ppat.1011273
Doijen, J., Temmerman, K., Van den Eynde, C., Diels, A., Van den Broeck, N., Van Gool, M., Heo, I., Jaensch, S., Zwaagstra, M., Diosa Toro, M., Chiu, W., De Jonghe, S., Leyssen, P., Bojkova, D., Ciesek, S., Cinatl, J., Verschueren, L., Buyck, C., Van Kuppeveld, F., ... Van Damme, E. (2023). Identification of Z-Tyr-Ala-CHN 2, a Cathepsin L Inhibitor with Broad-Spectrum Cell-Specific Activity against Coronaviruses, including SARS-CoV-2. Microorganisms, 11(3), Article 717. https://doi.org/10.3390/microorganisms11030717
Du, W., Janssens, R., Mykytyn, A. Z., Li, W., Drabek, D., van Haperen, R., Chatziandreou, M., Rissmann, M., van der Lee, J., van Dortmondt, M., Martin, I. S., van Kuppeveld, F. J. M., Hurdiss, D. L., Haagmans, B. L., Grosveld, F., & Bosch, B.-J. (2023). Avidity engineering of human heavy-chain-only antibodies mitigates neutralization resistance of SARS-CoV-2 variants. Frontiers in Immunology, 14, Article 1111385. https://doi.org/10.3389/fimmu.2023.1111385
Poelaert, K. C. K., van Kleef, R. G. D. M., Liu, M., van Vliet, A., Lyoo, H., Gerber, L.-S., Narimatsu, Y., Büll, C., Clausen, H., de Vries, E., Westerink, R. H. S., & van Kuppeveld, F. J. M. (2023). Enterovirus D-68 Infection of Primary Rat Cortical Neurons: Entry, Replication, and Functional Consequences. mBio, 14(2), Article e0024523. https://doi.org/10.1128/mbio.00245-23

2022

Scholarly publications

Aloise, C., Schipper, J. G., de Groot, R. J., & van Kuppeveld, F. J. (2022). Move and countermove: the integrated stress response in picorna- and coronavirus-infected cells. Current Opinion in Immunology, 79, 1-10. Article 102254. https://doi.org/10.1016/j.coi.2022.102254
Liu, M., Huang, L. Z. X., Smits, A. A., Büll, C., Narimatsu, Y., van Kuppeveld, F. J. M., Clausen, H., de Haan, C. A. M., & de Vries, E. (2022). Human-type sialic acid receptors contribute to avian influenza A virus binding and entry by hetero-multivalent interactions. Nature Communications, 13(1), 1-12. Article 4054. https://doi.org/10.1038/s41467-022-31840-0
de Vries, E., Guo, H., Du, W., Liu, M., van Kuppeveld, F. J. M., & de Haan, C. A. M. (2022). Quantification of Receptor Association, Dissociation, and NA-Dependent Motility of Influenza A Particles by Biolayer Interferometry. In Glycovirology: Methods and Protocols (pp. 123-140). (Methods in Molecular Biology; Vol. 2556). Humana Press. https://doi.org/10.1007/978-1-0716-2635-1_10
Rothenberger, S., Hurdiss, D. L., Walser, M., Malvezzi, F., Mayor, J., Ryter, S., Moreno, H., Liechti, N., Bosshart, A., Iss, C., Calabro, V., Cornelius, A., Hospodarsch, T., Neculcea, A., Looser, T., Schlegel, A., Fontaine, S., Villemagne, D., Paladino, M., ... Trimpert, J. (2022). The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants. Nature Biotechnology, 40(12), 1845-1854. https://doi.org/10.1038/s41587-022-01382-3
Pascha, M. N., Thijssen, V., Egido, J. E., Linthorst, M. W., van Lanen, J. H., van Dongen, D. A. A., Hopstaken, A. J. P., van Kuppeveld, F. J. M., Snijder, J., de Haan, C. A. M., & Jongkees, S. A. K. (2022). Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region: ACS Chemical Biology. ACS Chemical Biology, 17(9), 2425-2436. https://doi.org/10.1021/acschembio.2c00040
van der Grein, S. G., Defourny, K. A. Y., Rabouw, H. H., Goerdayal, S. S., van Herwijnen, M. J. C., Wubbolts, R. W., Altelaar, M., van Kuppeveld, F. J. M., & Nolte-'t Hoen, E. N. M. (2022). The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy. Nature Communications, 13(1), 1-14. Article 3625. https://doi.org/10.1038/s41467-022-31181-y
Wang, C., Hesketh, E. L., Shamorkina, T. M., Li, W., Franken, P. J., Drabek, D., van Haperen, R., Townend, S., van Kuppeveld, F. J. M., Grosveld, F., Ranson, N. A., Snijder, J., de Groot, R. J., Hurdiss, D. L., & Bosch, B.-J. (2022). Antigenic structure of the human coronavirus OC43 spike reveals exposed and occluded neutralizing epitopes. Nature Communications, 13(1), 1-15. Article 2921. https://doi.org/10.1038/s41467-022-30658-0
Luteijn, R. D., & van Kuppeveld, F. J. M. (2022). Rhinoviruses usurp STING for replication. Nature Microbiology, 7(5), 605-606. https://doi.org/10.1038/s41564-022-01117-9
Du, W., Hurdiss, D. L., Drabek, D., Mykytyn, A. Z., Kaiser, F. K., González-Hernández, M., Muñoz-Santos, D., Lamers, M. M., van Haperen, R., Li, W., Drulyte, I., Wang, C., Sola, I., Armando, F., Beythien, G., Ciurkiewicz, M., Baumgärtner, W., Guilfoyle, K., Smits, T., ... Bosch, B.-J. (2022). An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. Science immunology, 7(73), 1-15. Article eabp9312. https://doi.org/10.1126/sciimmunol.abp9312
Bardiot, D., Vangeel, L., Koukni, M., Arzel, P., Zwaagstra, M., Lyoo, H., Wanningen, P., Ahmad, S., Zhang, L., Sun, X., Delpal, A., Eydoux, C., Guillemot, J.-C., Lescrinier, E., Klaassen, H., Leyssen, P., Jochmans, D., Castermans, K., Hilgenfeld, R., ... Marchand, A. (2022). Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication. Molecules (Basel, Switzerland), 27(3), 1-26. Article 1052. https://doi.org/10.3390/molecules27031052
Hurdiss, D. L., El Kazzi, P., Bauer, L., Papageorgiou, N., Ferron, F. P., Donselaar, T., Van Vliet, A. L. W., Shamorkina, T. M., Snijder, J., Canard, B., Decroly, E., Brancale, A., Zeev-Ben-Mordehai, T., Förster, F., Van Kuppeveld, F. J. M., & Coutard, B. (2022). Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex. Science advances, 8(1), 1-12. Article abj7615. https://doi.org/10.1126/sciadv.abj7615

2021

Scholarly publications

Langereis, M. A., Albulescu, I. C., Stammen-Vogelzangs, J., Lambregts, M., Stachura, K., Miller, S., Bosco-Lauth, A. M., Hartwig, A. E., Porter, S. M., Allen, M., Mogler, M., van Kuppeveld, F. J. M., Bosch, B.-J., Vermeij, P., de Groof, A., Bowen, R. A., Davis, R., Xu, Z., & Tarpey, I. (2021). An alphavirus replicon-based vaccine expressing a stabilized Spike antigen induces protective immunity and prevents transmission of SARS-CoV-2 between cats. npj Vaccines, 6(1), Article 122. https://doi.org/10.1038/s41541-021-00390-9
Fröberg, J., Gillard, J., Philipsen, R., Lanke, K., Rust, J., van Tuijl, D., Teelen, K., Bousema, T., Simonetti, E., van der Gaast-de Jongh, C. E., Bos, M., van Kuppeveld, F. J., Bosch, B.-J., Nabuurs-Franssen, M., van der Geest-Blankert, N., van Daal, C., Huynen, M. A., de Jonge, M. I., & Diavatopoulos, D. A. (2021). SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms. Nature Communications, 12(1), 1-11. Article 5621. https://doi.org/10.1038/s41467-021-25949-x
Martina, M. G., Vicenti, I., Bauer, L., Crespan, E., Rango, E., Boccuto, A., Olivieri, N., Incerti, M., Zwaagstra, M., Allodi, M., Bertoni, S., Dreassi, E., Zazzi, M., van Kuppeveld, F. J. M., Maga, G., & Radi, M. (2021). Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIβ) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus and Human Rhinoviruses. ChemMedChem, 16(23), 3548-3552. https://doi.org/10.1002/cmdc.202100483
Ni, Y., Rosier, B. J. H. M., van Aalen, E. A., Hanckmann, E. T. L., Biewenga, L., Pistikou, A.-M. M., Timmermans, B., Vu, C., Roos, S., Arts, R., Li, W., de Greef, T. F. A., van Borren, M. M. G. J., van Kuppeveld, F. J. M., Bosch, B.-J., & Merkx, M. (2021). A plug-and-play platform of ratiometric bioluminescent sensors for homogeneous immunoassays. Nature Communications, 12(1), 1-12. Article 4586. https://doi.org/10.1038/s41467-021-24874-3
Haagmans, B. L., Noack, D., Okba, N. M. A., Li, W., Wang, C., Bestebroer, T., de Vries, R., Herfst, S., de Meulder, D., Verveer, E., van Run, P., Lamers, M. M., Rijnders, B., Rokx, C., van Kuppeveld, F., Grosveld, F., Drabek, D., GeurtsvanKessel, C., Koopmans, M., ... Rockx, B. (2021). SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a hamster model. Journal of Infectious Diseases, 223(12), 2020-2028. https://doi.org/10.1093/infdis/jiab289
https://dspace.library.uu.nl/bitstream/handle/1874/418815/jiab289.pdf?sequence=1
Klooster, J. P. T., Bol-Schoenmakers, M., van Summeren, K., van Vliet, A. L. W., de Haan, C. A. M., van Kuppeveld, F. J. M., Verkoeijen, S., & Pieters, R. (2021). Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine. Communications Biology, 4(1), 1-13. Article 631. https://doi.org/10.1038/s42003-021-02176-0
Dai, M., Du, W., Martínez-Romero, C., Leenders, T., Wennekes, T., Rimmelzwaan, G. F., van Kuppeveld, F. J. M., Fouchier, R. A. M., Garcia-Sastre, A., de Vries, E., & de Haan, C. A. M. (2021). Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics. mBio, 12(3), 1-18. Article e00287-21. https://doi.org/10.1128/mBio.00287-21
Fedry, J., Hurdiss, D. L., Wang, C., Li, W., Obal, G., Drulyte, I., Du, W., Howes, S. C., van Kuppeveld, F. J. M., Förster, F., & Bosch, B.-J. (2021). Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Science advances, 7(23), 1-11. Article eabf5632. https://doi.org/10.1126/sciadv.abf5632
Zhao, S., Schuurman, N., Li, W., Wang, C., Smit, L. A. M., Broens, E. M., Wagenaar, J. A., van Kuppeveld, F. J. M., Bosch, B.-J., & Egberink, H. (2021). Serologic Screening of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Cats and Dogs during First Coronavirus Disease Wave, the Netherlands. Emerging Infectious Diseases, 27(5), 1362-1370. https://doi.org/10.3201/eid2705.204055
Wallace, L. E., Liu, M., van Kuppeveld, F., de Vries, E., & de Haan, C. A. M. (2021). Respiratory mucus as a virus-host range determinant. Trends in Microbiology, 29(11), 983-992. https://doi.org/10.1016/j.tim.2021.03.014
https://dspace.library.uu.nl/bitstream/handle/1874/418777/PIIS0966842X21000731.pdf?sequence=1
Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., Li, W., Okba, N. M. A., Albulescu, I., Widjaja, I., van Dieren, B., Fernandez-Delgado, R., Sola, I., Hurdiss, D. L., Daramola, O., Grosveld, F., van Kuppeveld, F. J. M., Haagmans, B. L., Enjuanes, L., Drabek, D., & Bosch, B.-J. (2021). A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies. Nature Communications, 12(1), 1-15. Article 1715. https://doi.org/10.1038/s41467-021-21968-w
Du, W., de Vries, E., van Kuppeveld, F. J. M., Matrosovich, M., & de Haan, C. A. M. (2021). Second sialic acid-binding site of influenza A virus neuraminidase: Binding receptors for efficient release. The FEBS journal, 288(19), 5598-5612. https://doi.org/10.1111/febs.15668

2020

Scholarly publications

Lang, Y., Li, W., Li, Z., Koerhuis, D., van den Burg, A. C. S., Rozemuller, E., Bosch, B.-J., van Kuppeveld, F. J. M., Boons, G.-JPH., Huizinga, E. G., van der Schaar, H. M., & de Groot, R. J. (2020, Apr 5). Coronavirus hemagglutinin-esterase and spike proteins co-evolve for functional balance and optimal virion avidity. https://doi.org/10.1101/2020.04.03.003699
Amsterdam University Medical Center COVID-19 Biobank Study Group, (2020). Development of a SARS-CoV-2 Total Antibody Assay and the Dynamics of Antibody Response over Time in Hospitalized and Nonhospitalized Patients with COVID-19. Journal of Immunology, 205(12), 3491-3499. https://doi.org/10.4049/jimmunol.2000767
Sooksawasdi Na Ayudhya, S., Meijer, A., Bauer, L., Oude Munnink, B., Embregts, C., Leijten, L., Siegers, J. Y., Laksono, B. M., van Kuppeveld, F., Kuiken, T., GeurtsvanKessel, C., & van Riel, D. (2020). Erratum for Sooksawasdi Na Ayudhya et al., "Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1". mSphere, 5(6), 1. Article e00941-20. https://doi.org/10.1128/mSphere.01147-20
Sooksawasdi Na Ayudhya, S., Meijer, A., Bauer, L., Oude Munnink, B., Embregts, C., Leijten, L., Siegers, J. Y., Laksono, B. M., van Kuppeveld, F., Kuiken, T., Geurts-van Kessel, C., van Riel, D., & Lakdawala, S. (2020). Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1. mSphere, 5(6), Article e00941-20. https://doi.org/10.1128/mSphere.00941-20
Bauer, L., Manganaro, R., Zonsics, B., Hurdiss, D. L., Zwaagstra, M., Donselaar, T., Welter, N. G. E., van Kleef, R. G. D. M., Lopez, M. L., Bevilacqua, F., Raman, T., Ferla, S., Bassetto, M., Neyts, J., Strating, J. R. P. M., Westerink, R. H. S., Brancale, A., & van Kuppeveld, F. J. M. (2020). Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C. PLoS Biology, 18(11), Article e3000904. https://doi.org/10.1371/journal.pbio.3000904
Boersma, S., Rabouw, H. H., Bruurs, L. J. M., Pavlovič, T., van Vliet, A. L. W., Beumer, J., Clevers, H., van Kuppeveld, F. J. M., & Tanenbaum, M. E. (2020). Translation and Replication Dynamics of Single RNA Viruses. Cell, 183(7), 1930-1945.E23. https://doi.org/10.1016/j.cell.2020.10.019
Lang, Y., Li, W., Li, Z., Koerhuis, D., van den Burg, A. C. S., Rozemuller, E., Bosch, B.-J., van Kuppeveld, F. J. M., Boons, G.-J., Huizinga, E. G., van der Schaar, H. M., & de Groot, R. J. (2020). Coronavirus hemagglutinin-esterase and spike proteins coevolve for functional balance and optimal virion avidity. Proceedings of the National Academy of Sciences of the United States of America, 117(41), 25759-25770. https://doi.org/10.1073/pnas.2006299117
Hurdiss, D. L., Drulyte, I., Lang, Y., Shamorkina, T. M., Pronker, M. F., van Kuppeveld, F. J. M., Snijder, J., & de Groot, R. J. (2020). Cryo-EM structure of coronavirus-HKU1 haemagglutinin esterase reveals architectural changes arising from prolonged circulation in humans. Nature Communications, 11(1), 1-10. Article 4646. https://doi.org/10.1038/s41467-020-18440-6
Haagmans, B. L., Noack, D., Okba, N. MA., Li, W., Wang, C., de Vries, R., Herfst, S., de Meulder, D., van Run, P., Rijnders, B., Rokx, C., van Kuppeveld, F., Grosveld, F., GeurtsvanKessel, C., Koopmans, M., Jan Bosch, B., Kuiken, T., & Rockx, B. (2020). SARS-CoV-2 neutralizing human antibodies protect against lower respiratory tract disease in a 1 hamster model 2 3. bioRxiv. https://doi.org/10.1101/2020.08.24.264630
Zhao, S., Schuurman, N., Tieke, M., Quist, B., Zwinkels, S., van Kuppeveld, F., de Haan, C. A. M., & Egberink, H. (2020). Serological screening of influenza A virus antibodies in cats and dogs indicates frequent infection with different subtypes. Journal of Clinical Microbiology, 58(11), Article e01689-20. https://doi.org/10.1128/JCM.01689-20
Giansanti, P., Strating, J. R. P. M., Defourny, K. A. Y., Cesonyte, I., Bottino, A. M. S., Post, H., Viktorova, E. G., Ho, V. Q. T., Langereis, M. A., Belov, G. A., Nolte-'t Hoen, E. N. M., Heck, A. J. R., & van Kuppeveld, F. J. M. (2020). Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection. Nature Communications, 11(1), 1-12. Article 4332. https://doi.org/10.1038/s41467-020-18168-3
Du, W., Wolfert, M. A., Peeters, B., van Kuppeveld, F. J. M., Boons, G.-J., de Vries, E., & de Haan, C. A. M. (2020). Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin. PLoS Pathogens, 16(8), 1-20. Article e1008816. https://doi.org/10.1371/journal.ppat.1008816
van den Hoogen, B., Santoni, A., Sciumé, G., Bowie, A., O'Farrelly, C., O'Neill, L., Anthonsen, M., Pardali, K., Young, S., Bergthaler, A., Manel, N., Zahn, R., Kikkert, M., Snijder, E., van Kuppeveld, F., Fouchier, R., & Hiscott, J. (2020). Immunometabolism pathways as the basis for innovative anti-viral strategies (INITIATE): A Marie Sklodowska-Curie innovative training network. Virus Research, 287, Article 198094. https://doi.org/10.1016/j.virusres.2020.198094
Visser, L. J., Aloise, C., Swatek, K. N., Medina, G. N., Olek, K. M., Rabouw, H. H., de Groot, R. J., Langereis, M. A., de Los Santos, T., Komander, D., Skern, T., & van Kuppeveld, F. J. M. (2020). Dissecting distinct proteolytic activities of FMDV Lpro implicates cleavage and degradation of RLR signaling proteins, not its deISGylase/DUB activity, in type I interferon suppression. PLoS Pathogens, 16(7), 1-27. Article e1008702. https://doi.org/10.1371/journal.ppat.1008702
Rabouw, H. H., Visser, L. J., Passchier, T. C., Langereis, M. A., Liu, F., Giansanti, P., van Vliet, A. L. W., Dekker, J. G., van der Grein, S. G., Saucedo, J. G., Anand, A. A., Trellet, M. E., Bonvin, A. M. J. J., Walter, P., Heck, A. J. R., de Groot, R. J., & van Kuppeveld, F. J. M. (2020). Inhibition of the integrated stress response by viral proteins that block p-eIF2-eIF2B association. Nature Microbiology, 5, 1361-1373. https://doi.org/10.1038/s41564-020-0759-0
Wang, C., Li, W., Drabek, D., Okba, N. M. A., van Haperen, R., Osterhaus, A. D. M. E., van Kuppeveld, F. J. M., Haagmans, B. L., Grosveld, F., & Bosch, B.-J. (2020). A human monoclonal antibody blocking SARS-CoV-2 infection. Nature Communications, 11(1), 1-6. Article 2251. https://doi.org/10.1038/s41467-020-16256-y
Manganaro, R., Zonsics, B., Bauer, L., Lorenzo Lopez, M., Donselaar, T., Zwaagstra, M., Saporito, F., Ferla, S., Strating, J. R. P. M., Coutard, B., Hurdiss, D. L., van Kuppeveld, F. J. M., & Brancale, A. (2020). Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors. Antiviral Research, 178, Article 104781. https://doi.org/10.1016/j.antiviral.2020.104781
https://dspace.library.uu.nl/bitstream/handle/1874/432443/1-s2.0-S0166354219306187-main.pdf?sequence=1
Dirmeier, S., Dächert, C., van Hemert, M., Tas, A., Ogando, N. S., van Kuppeveld, F., Bartenschlager, R., Kaderali, L., Binder, M., & Beerenwinkel, N. (2020). Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation. PLoS Computational Biology, 16(2), Article e1007587. https://doi.org/10.1371/journal.pcbi.1007587

2019

Scholarly publications

Melia, C. E., Peddie, C. J., de Jong, A. W. M., Snijder, E. J., Collinson, L. M., Koster, A. J., van der Schaar, H. M., van Kuppeveld, F. J. M., & Bárcena, M. (2019). Origins of Enterovirus Replication Organelles Established by Whole-Cell Electron Microscopy. mBio, 10(3). https://doi.org/10.1128/mBio.00951-19
Widjaja, I., Wang, C., van Haperen, R., Gutiérrez-Álvarez, J., van Dieren, B., Okba, N. M. A., Raj, V. S., Li, W., Fernandez-Delgado, R., Grosveld, F., van Kuppeveld, F. J. M., Haagmans, B. L., Enjuanes, L., Drabek, D., & Bosch, B. J. (2019). Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein. Emerging Microbes and Infections, 8(1), 516-530. https://doi.org/10.1080/22221751.2019.1597644
Zhao, S., Smits, C., Schuurman, N., Barnum, S., Pusterla, N., Kuppeveld, F. V., Bosch, B.-J., Maanen, K. V., & Egberink, H. (2019). Development and Validation of a S1 Protein-Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus. Viruses, 11(12). https://doi.org/10.3390/v11121109
Bauer, L., Manganaro, R., Zonsics, B., Strating, J. R. P. M., El Kazzi, P., Lorenzo Lopez, M., Ulferts, R., van Hoey, C., Mate, M. J., Langer, T., Coutard, B., Brancale, A., & van Kuppeveld, F. J. M. (2019). Fluoxetine inhibits enterovirus replication by targeting the viral 2C protein in a stereospecific manner. ACS Infect Dis, 5(9), 1609-1623. https://doi.org/10.1021/acsinfecdis.9b00179
Schuster, S., Overheul, G. J., Bauer, L., van Kuppeveld, F. J. M., & van Rij, R. P. (2019). No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells. Scientific Reports, 9(1), Article 13752. https://doi.org/10.1038/s41598-019-50287-w
Baggen, J., Liu, Y., Lyoo, H., van Vliet, A. L. W., Wahedi, M., de Bruin, J. W., Roberts, R. W., Overduin, P., Meijer, A., Rossmann, M. G., Thibaut, H. J., & van Kuppeveld, F. J. M. (2019). Bypassing pan-enterovirus host factor PLA2G16. Nature Communications, 10(1), Article 3171. https://doi.org/10.1038/s41467-019-11256-z
Sun, L., Tijsma, A., Mirabelli, C., Baggen, J., Wahedi, M., Franco, D., De Palma, A., Leyssen, P., Verbeken, E., van Kuppeveld, F. J. M., Neyts, J., & Thibaut, H. J. (2019). Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence. Emerging Microbes and Infections, 8(1), 1076-1085. https://doi.org/10.1080/22221751.2019.1644142
Baggen, J., Thibaut, H. J., Hurdiss, D. L., Wahedi, M., Marceau, C. D., van Vliet, A. L. W., Carette, J. E., & van Kuppeveld, F. J. M. (2019). Identification of the Cell-Surface Protease ADAM9 as an Entry Factor for Encephalomyocarditis Virus. mBio, 10(4), Article e01780-19. https://doi.org/10.1128/mBio.01780-19
Zhao, S., Li, W., Schuurman, N., van Kuppeveld, F., Bosch, B.-J., & Egberink, H. (2019). Serological Screening for Coronavirus Infections in Cats. Viruses, 11(8), Article 743. https://doi.org/10.3390/v11080743
Belov, G. A., & van Kuppeveld, F. J. M. (2019). Lipid Droplets Grease Enterovirus Replication. Cell Host & Microbe, 26(2), 149-151. https://doi.org/10.1016/j.chom.2019.07.017
Horova, V., Lyoo, H., Różycki, B., Chalupska, D., Smola, M., Humpolickova, J., Strating, J. R. P. M., van Kuppeveld, F. J. M., Boura, E., & Klima, M. (2019). Convergent evolution in the mechanisms of ACBD3 recruitment to picornavirus replication sites. PLoS Pathogens, 15(8), Article e1007962. https://doi.org/10.1371/journal.ppat.1007962
McPhail, J. A., Lyoo, H. R., Pemberton, J. G., Hoffmann, R. M., Elst, W. V., Strating, J. R. P. M., Jenkins, M. L., Stariha, J. T. B., Kuppeveld, F. J. M. V., Balla, T., & Burke, J. E. (2019). Characterization of the Golgi c10orf76-PI4KB complex, and its necessity for Golgi PI4P levels and enterovirus replication. EMBO Reports, Article e48441. https://doi.org/10.15252/embr.201948441
Du, W., Guo, H., Nijman, V. S., Doedt, J., van der Vries, E., van der Lee, J., Li, Z., Boons, G.-J., van Kuppeveld, F. J. M., de Vries, E., Matrosovich, M., & de Haan, C. A. M. (2019). The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLoS Pathogens, 15(6), Article e1007860. https://doi.org/10.1371/journal.ppat.1007860
Visser, L. J., Langereis, M. A., Rabouw, H. H., Wahedi, M., Muntjewerff, E. M., de Groot, R. J., & van Kuppeveld, F. J. M. (2019). Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I interferon. Journal of Virology, 93(10), Article e00222-19. https://doi.org/10.1128/JVI.00222-19
van der Grein, S. G., Defourny, K. A. Y., Rabouw, H. H., Galiveti, C. R., Langereis, M. A., Wauben, M. H. M., Arkesteijn, G. J. A., van Kuppeveld, F. J. M., & Nolte-'t Hoen, E. N. M. (2019). Picornavirus infection induces temporal release of multiple extracellular vesicle subsets that differ in molecular composition and infectious potential. PLoS Pathogens, 15(2), Article e1007594. https://doi.org/10.1371/journal.ppat.1007594
Lyoo, H., van der Schaar, H. M., Dorobantu, C. M., Rabouw, H. H., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2019). ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB. mBio, 10(1), Article e02742-18. https://doi.org/10.1128/mBio.02742-18
Rabouw, H. H., Langereis, M. A., Anand, A. A., Visser, L. J., de Groot, R. J., Walter, P., & van Kuppeveld, F. J. M. (2019). Small molecule ISRIB suppresses the integrated stress response within a defined window of activation. Proceedings of the National Academy of Sciences of the United States of America, 116(6), 2097-2102. https://doi.org/10.1073/pnas.1815767116
Hulswit, R. J. G., Lang, Y., Bakkers, M. J. G., Li, W., Li, Z., Schouten, A., Ophorst, B., van Kuppeveld, F. J. M., Boons, G.-J., Bosch, B.-J., Huizinga, E. G., & de Groot, R. J. (2019). Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A. Proceedings of the National Academy of Sciences of the United States of America, 116(7), 2681-2690. https://doi.org/10.1073/pnas.1809667116
Visser, L. J., Medina, G. N., Rabouw, H. H., de Groot, R. J., Langereis, M. A., de Los Santos, T., & van Kuppeveld, F. J. M. (2019). FMDV leader protease cleaves G3BP1 and G3BP2 and inhibits stress granule formation. Journal of Virology, 93(2), Article e00922-18. https://doi.org/10.1128/JVI.00922-18
Ma, Y., Cong, W., Huang, H., Sun, L., Mai, A. H., Boonen, K., Maryam, W., De Borggraeve, W., Luo, G., Liu, Q., Schoofs, L., Van Kuppeveld, F., Neyts, J., Mirabelli, C., & Luyten, W. (2019). Identification of fukinolic acid from Cimicifuga heracleifolia and its derivatives as novel antiviral compounds against enterovirus A71 infection. International Journal of Antimicrobial Agents, 53(2), 128-136. https://doi.org/10.1016/j.ijantimicag.2018.07.014

2018

Scholarly publications

Liu, Y., Sheng, J., van Vliet, A. L. W., Buda, G., van Kuppeveld, F. J. M., & Rossmann, M. G. (2018). Molecular basis for the acid-initiated uncoating of human enterovirus D68. Proceedings of the National Academy of Sciences of the United States of America, 115(52), E12209-E12217. https://doi.org/10.1073/pnas.1803347115
Du, W., Dai, M., Li, Z., Boons, G.-J., Peeters, B., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2018). Substrate binding by the 2 sialic acid-binding site of influenza A virus N1 neuraminidase contributes to enzymatic activity. Journal of Virology, 92(20), Article e01243-18. https://doi.org/10.1128/JVI.01243-18
Guo, H., Rabouw, H., Slomp, A., Dai, M., van der Vegt, F., van Lent, J. W. M., McBride, R., Paulson, J. C., de Groot, R. J., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2018). Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces. PLoS Pathogens, 14(8), Article e1007233. https://doi.org/10.1371/journal.ppat.1007233
Koestner, W., Spanier, J., Klause, T., Tegtmeyer, P.-K., Becker, J., Herder, V., Borst, K., Todt, D., Lienenklaus, S., Gerhauser, I., Detje, C. N., Geffers, R., Langereis, M. A., Vondran, F. W. R., Yuan, Q., van Kuppeveld, F. J. M., Ott, M., Staeheli, P., Steinmann, E., ... Kalinke, U. (2018). Interferon-beta expression and type I interferon receptor signaling of hepatocytes prevent hepatic necrosis and virus dissemination in Coxsackievirus B3-infected mice. PLoS Pathogens, 14(8), Article e1007235. https://doi.org/10.1371/journal.ppat.1007235
Meutiawati, F., Bezemer, B., Strating, J. R. P. M., Overheul, G. J., Žusinaite, E., van Kuppeveld, F. J. M., van Cleef, K. W. R., & van Rij, R. P. (2018). Posaconazole inhibits dengue virus replication by targeting oxysterol-binding protein. Antiviral Research, 157, 68-79. https://doi.org/10.1016/j.antiviral.2018.06.017
Bauer, L., Ferla, S., Head, S. A., Bhat, S., Pasunooti, K. K., Shi, W. Q., Albulescu, L., Liu, J. O., Brancale, A., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2018). Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP). Antiviral Research, 156, 55-63. https://doi.org/10.1016/j.antiviral.2018.05.010
Li, W., Hulswit, R. J. G., Kenney, S. P., Widjaja, I., Jung, K., Alhamo, M. A., van Dieren, B., van Kuppeveld, F. J. M., Saif, L. J., & Bosch, B.-J. (2018). Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility. Proceedings of the National Academy of Sciences of the United States of America, 115(22), e5135-e5143. https://doi.org/10.1073/pnas.1802879115
Melia, C. E., van der Schaar, H. M., de Jong, A. W. M., Lyoo, H. R., Snijder, E. J., Koster, A. J., van Kuppeveld, F. J. M., & Bárcena, M. (2018). The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles. mBio, 9(2), Article e00420-18. https://doi.org/10.1128/mBio.00420-18
Baggen, J., Jan Thibaut, H., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2018). The life cycle of non-polio enteroviruses and how to target it. Nature Reviews Microbiology, 16(6), 368-381. https://doi.org/10.1038/s41579-018-0005-4
Swatek, K. N., Aumayr, M., Pruneda, J. N., Visser, L. J., Berryman, S., Kueck, A. F., Geurink, P. P., Ovaa, H., van Kuppeveld, F. J. M., Tuthill, T. J., Skern, T., & Komander, D. (2018). Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies. Proceedings of the National Academy of Sciences of the United States of America, 115(10), 2371-2376. https://doi.org/10.1073/pnas.1710617115
Baggen, J., Hurdiss, D. L., Zocher, G., Mistry, N., Roberts, R. W., Slager, J. J., Guo, H., van Vliet, A. L. W., Wahedi, M., Benschop, K., Duizer, E., de Haan, C. A. M., de Vries, E., Casasnovas, J. M., de Groot, R. J., Arnberg, N., Stehle, T., Ranson, N. A., Thibaut, H. J., & van Kuppeveld, F. J. M. (2018). Role of enhanced receptor engagement in the evolution of a pandemic acute hemorrhagic conjunctivitis virus. Proceedings of the National Academy of Sciences of the United States of America, 115(2), 397-402. https://doi.org/10.1073/pnas.1713284115

2017

Scholarly publications

Schuster, S., Tholen, L. E., Overheul, G. J., van Kuppeveld, F. J. M., & van Rij, R. P. (2017). Deletion of Cytoplasmic Double-Stranded RNA Sensors Does Not Uncover Viral Small Interfering RNA Production in Human Cells. mSphere, 2(4), Article e00333-17. https://doi.org/10.1128/mSphere.00333-17
Lyoo, H., Dorobantu, C. M., van der Schaar, H. M., & van Kuppeveld, F. J. M. (2017). Modulation of proteolytic polyprotein processing by coxsackievirus mutants resistant to inhibitors targeting phosphatidylinositol-4-kinase IIIβ or oxysterol binding protein. Antiviral Research, 147, 86-90. https://doi.org/10.1016/j.antiviral.2017.10.006
Melia, C. E., van der Schaar, H. M., Lyoo, H., Limpens, R. W. A. L., Feng, Q., Wahedi, M., Overheul, G. J., van Rij, R. P., Snijder, E. J., Koster, A. J., Bárcena, M., & van Kuppeveld, F. J. M. (2017). Escaping Host Factor PI4KB Inhibition: Enterovirus Genomic RNA Replication in the Absence of Replication Organelles. Cell Reports, 21(3), 587-599. https://doi.org/10.1016/j.celrep.2017.09.068
Li, W., Hulswit, R. J. G., Widjaja, I., Raj, V. S., McBride, R., Peng, W., Widagdo, W., Tortorici, M. A., van Dieren, B., Lang, Y., van Lent, J. W. M., Paulson, J. C., de Haan, C. A. M., de Groot, R. J., van Kuppeveld, F. J. M., Haagmans, B. L., & Bosch, B.-J. (2017). Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 114(40), E8508-E8517. https://doi.org/10.1073/pnas.1712592114
Bauer, L., Lyoo, H., van der Schaar, H. M., Strating, J. R., & van Kuppeveld, F. J. (2017). Direct-acting antivirals and host-targeting strategies to combat enterovirus infections. Current Opinion in Virology, 24, 1-8. https://doi.org/10.1016/j.coviro.2017.03.009
Li, W., Luo, R., He, Q., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B.-J. (2017). Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus Research, 235, 6-13. https://doi.org/10.1016/j.virusres.2017.03.018
Bakkers, M. J. G., Lang, Y., Feitsma, L. J., Hulswit, R. J. G., de Poot, S. A. H., van Vliet, A. L. W., Margine, I., de Groot-Mijnes, J. D. F., van Kuppeveld, F. J. M., Langereis, M. A., Huizinga, E. G., & de Groot, R. J. (2017). Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity. Cell Host and Microbe, 21(3), 356-366. https://doi.org/10.1016/j.chom.2017.02.008
Strating, J. R., & van Kuppeveld, F. J. (2017). Viral rewiring of cellular lipid metabolism to create membranous replication compartments. Current Opinion in Cell Biology, 47, 24-33. https://doi.org/10.1016/j.ceb.2017.02.005
Dai, M., McBride, R., Dortmans, J. C. F. M., Peng, W., Bakkers, M. J. G., de Groot, R. J., van Kuppeveld, F. J. M., Paulson, J. C., de Vries, E., & de Haan, C. A. M. (2017). Mutation of the 2(nd) Sialic Acid-Binding Site Resulting in Reduced Neuraminidase Activity Preceded Emergence of H7N9 Influenza A Virus. Journal of Virology, 91(9), Article e00049-17. https://doi.org/10.1128/JVI.00049-17
Kindler, E., Gil-Cruz, C., Spanier, J., Li, Y., Wilhelm, J., Rabouw, H. H., Züst, R., Hwang, M., V'kovski, P., Stalder, H., Marti, S., Habjan, M., Cervantes-Barragan, L., Elliot, R., Karl, N., Gaughan, C., van Kuppeveld, F. J. M., Silverman, R. H., Keller, M., ... Thiel, V. (2017). Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS Pathogens, 13(2), Article e1006195. https://doi.org/10.1371/journal.ppat.1006195
Albulescu, L., Bigay, J., Biswas, B., Weber-Boyvat, M., Dorobantu, C. M., Delang, L., van der Schaar, H. M., Jung, Y.-S., Neyts, J., Olkkonen, V. M., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2017). Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Research, 140, 37-44. https://doi.org/10.1016/j.antiviral.2017.01.008
Staring, J., von Castelmur, E., Blomen, V. A., van den Hengel, L. G., Brockmann, M., Baggen, J., Thibaut, H. J., Nieuwenhuis, J., Janssen, H., van Kuppeveld, F. J. M., Perrakis, A., Carette, J. E., & Brummelkamp, T. R. (2017). PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature, 541, 412-416. Article 21032. https://doi.org/10.1038/nature21032
Guo, H., de Vries, E., McBride, R., Dekkers, J., Bouwman, K. M., Nycholat, C., Verheije, M. H., Paulson, J. C., van Kuppeveld, F. J. M., & de Haan, C. A. M. (2017). Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Emerging Infectious Diseases, 23(2). https://doi.org/10.3201/eid2302.161072

2016

Scholarly publications

Domsgen, E., Lind, K., Kong, L., Hühn, M. H., Rasool, O., van Kuppeveld, F., Korsgren, O., Lahesmaa, R., & Flodström-Tullberg, M. (2016). An IFIH1 gene polymorphism associated with risk for autoimmunity regulates canonical antiviral defence pathways in Coxsackievirus infected human pancreatic islets. Scientific Reports, 6, Article 39378. https://doi.org/10.1038/srep39378
Rabouw, H. H., Langereis, M. A., Knaap, R. C. M., Dalebout, T. J., Canton, J., Sola, I., Enjuanes, L., Bredenbeek, P. J., Kikkert, M., de Groot, R. J., & van Kuppeveld, F. J. M. (2016). Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress Responses. PLoS Pathogens, 12(10), 1-26. Article e1005982. https://doi.org/10.1371/journal.ppat.1005982
Nagy, P. D., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2016). Building Viral Replication Organelles: Close Encounters of the Membrane Types. PLoS Pathogens, 12(10), 1-6. Article 1005912. https://doi.org/10.1371/journal.ppat.1005912
Mauthe, M., Langereis, M., Jung, J., Zhou, X., Jones, A., Omta, W., Tooze, S. A., Stork, B., Paludan, S. R., Ahola, T., Egan, D., Behrends, C., Mokry, M., de Haan, X., van Kuppeveld, F., & Reggiori, F. (2016). An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication. Journal of Cell Biology, 214(5), 619-635. https://doi.org/10.1083/jcb.201602046
Dai, M., Guo, H., Dortmans, J., Dekkers, J., Nordholm, J., Daniels, R., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2016). Identification of residues that affect oligomerization and/or enzymatic activity of influenza virus H5N1 neuraminidase proteins. Journal of Virology, 90(20), 9457-9470. https://doi.org/10.1128/JVI.01346-16
Dorobantu, C. M., Harak, C., Klein, R., van der Linden, L., Strating, J. R. P. M., van der Schaar, H. M., Lohmann, V., & van Kuppeveld, F. J. M. (2016). Tyrphostin AG1478 inhibits encephalomyocarditis virus and hepatitis C virus by targeting phosphatidylinositol 4-kinase IIIα. Antimicrobial Agents and Chemotherapy, 60(10), 6402-6406. https://doi.org/10.1128/AAC.01331-16
van der Schaar, H. M., Melia, C. E., van Bruggen, J. A. C., Strating, J. R. P. M., van Geenen, M. E. D., Koster, A. J., Bárcena, M., & van Kuppeveld, F. J. M. (2016). Illuminating the Sites of Enterovirus Replication in Living Cells by Using a Split-GFP-Tagged Viral Protein. mSphere, 1(4), 1-17. Article e00104-16. https://doi.org/10.1128/mSphere.00104-16
Kint, J., Langereis, M. A., Maier, H. J., Britton, P., van Kuppeveld, F. J., Koumans, J., Wiegertjes, G. F., & Forlenza, M. (2016). Infectious bronchitis coronavirus limits interferon production by inducing a host shutoff that requires accessory protein 5b. Journal of Virology, 90(16), 7519-7528. https://doi.org/10.1128/JVI.00627-16
Mullapudi, E., Nováček, J., Pálková, L., Kulich, P., Lindberg, A. M., van Kuppeveld, F. J. M., & Plevka, P. (2016). Structure and genome release mechanism of human cardiovirus Saffold virus-3. Journal of Virology, 90(17), 7628-7639. https://doi.org/10.1128/JVI.00746-16
Dorobantu, C. M., Albulescu, L., Lyoo, H., van Kampen, M., De Francesco, R., Lohmann, V., Harak, C., van der Schaar, H. M., Strating, J. R. P. M., Gorbalenya, A. E., & van Kuppeveld, F. J. M. (2016). Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein. mSphere, 1(3), Article e00068-16. https://doi.org/10.1128/mSphere.00068-16
Li, W., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B.-J. (2016). Cellular entry of the porcine epidemic diarrhea virus. Virus Research, 226, 117-127. https://doi.org/10.1016/j.virusres.2016.05.031
Bakkers, M. J. G., Zeng, Q., Feitsma, L. J., Hulswit, R. J. G., Li, Z., Westerbeke, A., van Kuppeveld, F. J. M., Boons, G.-J., Langereis, M. A., Huizinga, E. G., & de Groot, R. J. (2016). Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation. Proceedings of the National Academy of Sciences of the United States of America, 113(22), E3111-E3119. https://doi.org/10.1073/pnas.1519881113
van der Schaar, H. M., Dorobantu, C. M., Albulescu, L., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2016). Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles. Trends in Microbiology, 24(7), 535-546. https://doi.org/10.1016/j.tim.2016.02.017
Arts, P., van de Veerdonk, F. L., van der Lee, R., Langereis, M. A., Gilissen, C., van Zelst-Stams, W. A. G., Huynen, M. A., van der Meer, J. W. M., van Kuppeveld, F. J., Veltman, J. A., Kullberg, B. J., Hoischen, A., & Netea, M. G. (2016). Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy. Journal of Allergy and Clinical Immunology, 138(3), 895-898. https://doi.org/10.1016/j.jaci.2016.02.025
Humoud, M. N., Doyle, N., Royall, E., Willcocks, M. M., Sorgeloos, F., van Kuppeveld, F., Roberts, L. O., Goodfellow, I. G., Langereis, M. A., & Locker, N. (2016). Feline Calicivirus infection disrupts the assembly of cytoplasmic stress granules and induces G3BP1 cleavage. Journal of Virology, 90(14), 6489-6501. https://doi.org/10.1128/JVI.00647-16
Widjaja, I., Wicht, O., Luytjes, W., Leenhouts, K., Rottier, P. J. M., van Kuppeveld, F. J. M., Haijema, B. J., & de Haan, C. A. M. (2016). Characterization of epitope-specific anti-RSV antibody responses after natural infection and after vaccination with formalin-inactivated RSV. Journal of Virology, 90(13), 5965-5977. https://doi.org/10.1128/JVI.00235-16
Lardinois, C., Sorgeloos, F., Jacobs, S., van Kuppeveld, F. J. M., Kaspers, B., & Michiels, T. (2016). Neurotropism of Saffold virus in a mouse model. Journal of General Virology, 97, 1350-1355. https://doi.org/10.1099/jgv.0.000452
Ulferts, R., de Boer, M., van der Linden, L., Bauer, L., Lyoo, H. R., Maté, M. J., Lichière, J., Canard, B., Lelieveld, D., Omta, W., Egan, D., Coutard, B., & van Kuppeveld, F. J. M. (2016). Screening of a library of FDA-approved drugs identifies several enterovirus replicaton inhibitors that target viral protein 2C. Antimicrobial Agents and Chemotherapy, 60(5), 2627-2638. https://doi.org/10.1128/AAC.02182-15
Baglio, S. R., van Eijndhoven, M. A. J., Koppers-Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Léveillé, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., Verkuijlen, S. A. W. M., Scheffer, G. L., van Kuppeveld, F. J. M., de Gruijl, T. D., Bultink, I. E. M., Jordanova, E. S., Hackenberg, M., Piersma, S. R., Knol, J. C., ... Pegtel, D. M. (2016). Sensing of latent EBV infection through exosomal transfer of 5'pppRNA. Proceedings of the National Academy of Sciences of the United States of America, 113(5), E587-E597. https://doi.org/10.1073/pnas.1518130113
Baggen, J., Thibaut, H. J., Staring, J., Jae, L. T., Liu, Y., Guo, H., Slager, J. J., de Bruin, J. W., van Vliet, A. L. W., Blomen, V. A., Overduin, P., Sheng, J., de Haan, X., de Vries, E., Meijer, A., Rossmann, M. G., Brummelkamp, T. R., & van Kuppeveld, F. J. M. (2016). Enterovirus D68 receptor requirements unveiled by haploid genetics. Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1399-1404. https://doi.org/10.1073/pnas.1524498113

2015

Scholarly publications

Liu, Y., Sheng, J., Baggen, J., Meng, G., Xiao, C., Thibaut, H. J., van Kuppeveld, F. J. M., & Rossmann, M. G. (2015). Sialic acid-dependent cell entry of human enterovirus D68. Nature Communications [E], 6, Article 8865. https://doi.org/10.1038/ncomms9865
Kang, H., Kim, C., Kim, D.-E., Song, J.-H., Choi, M., Choi, K., Kang, M., Lee, K., Kim, H. S., Shin, J. S., Kim, J., Han, S.-B., Lee, M.-Y., Lee, S. U., Lee, C.-K., Kim, M., Ko, H.-J., van Kuppeveld, F. J. M., & Cho, S. (2015). Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses. Antiviral Research, 124, 1-10. https://doi.org/10.1016/j.antiviral.2015.10.011
van der Lee, R., Feng, Q., Langereis, M. A., Ter Horst, R., Szklarczyk, R., Netea, M. G., Andeweg, A. C., van Kuppeveld, F. J. M., & Huynen, M. A. (2015). Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response. PLoS Computational Biology, 11(10), Article e1004553. https://doi.org/10.1371/journal.pcbi.1004553
Dorobantu, C. M., Albulescu, L., Harak, C., Feng, Q., van Kampen, M., Strating, J. R. P. M., Gorbalenya, A. E., Lohmann, V., van der Schaar, H. M., & van Kuppeveld, F. J. M. (2015). Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. PLoS Pathogens, 11(9), Article e1005185. https://doi.org/10.1371/journal.ppat.1005185
Sun, L., Meijer, A., Froeyen, M., Zhang, L., Thibaut, H. J., Baggen, J., George, S., Vernachio, J., van Kuppeveld, F. J. M., Leyssen, P., Hilgenfeld, R., Neyts, J., & Delang, L. (2015). Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68. Antimicrobial Agents and Chemotherapy, 59(12), 7782-7785. https://doi.org/10.1128/AAC.01375-15
Langereis, M. A., Rabouw, H. H., Holwerda, M., Visser, L. J., & van Kuppeveld, F. J. M. (2015). cGAS and STING knockout rescues virus infection of plasmid DNA-transfected cells. Journal of Virology, 89(21), 11169-11173. https://doi.org/10.1128/JVI.01781-15
Cancellieri, M., Bassetto, M., Widjaja, I., van Kuppeveld, F., de Haan, C. A. M., Brancale, A., & de Haan, C. A. M. (2015). In silico structure-based design and synthesis of novel anti-RSV compounds. Antiviral Research, 122, 46-50. https://doi.org/10.1016/j.antiviral.2015.08.003
Linden, L. V. D., Wolthers, K. C., & van Kuppeveld, F. J. M. (2015). Replication and Inhibitors of Enteroviruses and Parechoviruses. Viruses [E], 7(8), 4529-4562. https://doi.org/10.3390/v7082832
Widjaja, I., Rigter, A., Jacobino, S., van Kuppeveld, F. J. M., Leenhouts, K., Palomo, C., Melero, J. A., Leusen, J. H. W., Haijema, B. J., Rottier, P. J. M., & de Haan, C. A. M. (2015). Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics. PLoS One, 10(6), Article e0130829. https://doi.org/10.1371/journal.pone.0130829
Langereis, M. A., Bakkers, M. J. G., Deng, L., Padler-Karavani, V., Vervoort, S. J., Hulswit, R. J. G., van Vliet, A. L. W., Gerwig, G. J., de Poot, S. A. H., Boot, W., van Ederen, A. M., Heesters, B. A., van der Loos, C. M., van Kuppeveld, F. J. M., Yu, H., Huizinga, E. G., Chen, X., Varki, A., Kamerling, J. P., & de Groot, R. J. (2015). Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Reports [E], 11(12), 1966-1978. https://doi.org/10.1016/j.celrep.2015.05.044
Li, W., Wicht, O., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B.-J. (2015). A single point mutation creating a furin cleavage site in the spike protein renders porcine epidemic diarrhea coronavirus trypsin-independent for cell entry and fusion. Journal of Virology, 89(15), 8077-8081. https://doi.org/10.1128/JVI.00356-15
de Vries, E., Guo, H., Dai, M., Rottier, P. J. M., van Kuppeveld, F. J. M., & de Haan, C. A. M. (2015). Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant. Emerging Infectious Diseases, 21(5), 842-846. https://doi.org/10.3201/eid2105.141927
Schulte, B. M., Gielen, P. R., Kers-Rebel, E. D., Schreibelt, G., van Kuppeveld, F. J. M., & Adema, G. J. (2015). Enterovirus-Infected β-Cells Induce Distinct Response Patterns in BDCA1+ and BDCA3+ Human Dendritic Cells. PLoS One, 10(3), Article e0121670. https://doi.org/10.1371/journal.pone.0121670
Reineke, L. C., Kedersha, N., Langereis, M. A., van Kuppeveld, F. J. M., & Lloyd, R. E. (2015). Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1. MBio [E], 6(2), Article e02486-14 . https://doi.org/10.1128/mBio.02486-14
van der Linden, L., Vives-Adrián, L., Selisko, B., Ferrer-Orta, C., Liu, X., Lanke, K., Ulferts, R., De Palma, A. M., Tanchis, F., Goris, N., Lefebvre, D., De Clercq, K., Leyssen, P., Lacroix, C., Pürstinger, G., Coutard, B., Canard, B., Boehr, D. D., Arnold, J. J., ... van Kuppeveld, F. J. M. (2015). The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. PLoS Pathogens, 11(3), Article e1004733. https://doi.org/10.1371/journal.ppat.1004733
Albulescu, L., Strating, J. R. P. M., Thibaut, H. J., van der Linden, L., Shair, M. D., Neyts, J., & van Kuppeveld, F. J. M. (2015). Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP. Antiviral Research, 117, 110-114. https://doi.org/10.1016/j.antiviral.2015.02.013
Helms, B., Kaloyanova, D. V., Strating, J. R. P., van Hellemond, J. J., van der Schaar, H. M., Tielens, A. G. M., van Kuppeveld, F. J. M., & Brouwers, J. F. (2015). Targeting of the hydrophobic metabolome by pathogens. Traffic, 16(5), 439-460. https://doi.org/10.1111/tra.12280
Albulescu, L., Wubbolts, R., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2015). Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus. Cellular Microbiology, 17(8), 1144-1156. https://doi.org/10.1111/cmi.12425
Burkard, C., Verheije, M. H., Haagmans, B. L., van Kuppeveld, F. J., Rottier, P. J. M., Bosch, B.-J., & de Haan, C. A. M. (2015). ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. Journal of Virology, 89(8), 4434-4448. https://doi.org/10.1128/JVI.03274-14
Strating, J. R. P. M., van der Linden, L., Albulescu, L., Bigay, J., Arita, M., Delang, L., Leyssen, P., van der Schaar, H. M., Lanke, K. H. W., Thibaut, H. J., Ulferts, R., Drin, G., Schlinck, N., Wubbolts, R. W., Sever, N., Head, S. A., Liu, J. O., Beachy, P. A., De Matteis, M. A., ... van Kuppeveld, F. J. M. (2015). Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein. Cell Reports [E], 10(4), 600-615. https://doi.org/10.1016/j.celrep.2014.12.054

2014

Scholarly publications

Thibaut, H. J., van der Schaar, H. M., Lanke, K. H. W., Verbeken, E., Andrews, M., Leyssen, P., Neyts, J., & van Kuppeveld, F. J. M. (2014). Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta. Journal of Virology, 88(5), 3048-3051. https://doi.org/10.1128/JVI.03177-13
Feng, Q., Langereis, M. A., Lork, M., Nguyen, M., Hato, S. V., Lanke, K., Emdad, L., Bhoopathi, P., Fisher, P. B., Lloyd, R. E., & van Kuppeveld, F. J. M. (2014). Enterovirus 2Apro targets MDA5 and MAVS in infected cells. Journal of Virology, 88(6), 3369-3378. https://doi.org/10.1128/JVI.02712-13
van der Linden, L., Ulferts, R., Nabuurs, S. B., Kusov, Y., Liu, H., George, S., Lacroix, C., Goris, N., Lefebvre, D., Lanke, K. H. W., De Clercq, K., Hilgenfeld, R., Neyts, J., & van Kuppeveld, F. J. M. (2014). Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases. Antiviral Research, 103, 17-24. https://doi.org/10.1016/j.antiviral.2013.12.012
Vives-Adrian, L., Lujan, C., Oliva, B., van der Linden, L., Selisko, B., Coutard, B., Canard, B., van Kuppeveld, F. J. M., Ferrer-Orta, C., & Verdaguer, N. (2014). The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site. Journal of Virology, 88(10), 5595-5607. https://doi.org/10.1128/JVI.03502-13
Deddouche, S., Goubau, D., Rehwinkel, J., Chakravarty, P., Begum, S., Maillard, P. V., Borg, A., Matthews, N., Feng, Q., van Kuppeveld, F. J. M., & Reis e Sousa, C. (2014). Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells. eLife, 3, Article e01535. https://doi.org/10.7554/eLife.01535
Thibaut, H. J., van der Linden, L., Jiang, P., Thys, B., Canela, M.-D., Aguado, L., Rombaut, B., Wimmer, E., Paul, A., Pérez-Pérez, M.-J., van Kuppeveld, F. J. M., & Neyts, J. (2014). Binding of glutathione to enterovirus capsids is essential for virion morphogenesis. PLoS Pathogens, 10(4), e1004039. https://doi.org/10.1371/journal.ppat.1004039
Feng, Q., Langereis, M. A., Olagnier, D., Chiang, C., van de Winkel, R., van Essen, P., Zoll, J., Hiscott, J., & van Kuppeveld, F. J. M. (2014). Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation. PLoS One, 9(4), e95927. https://doi.org/10.1371/journal.pone.0095927
Feng, Q., Langereis, M. A., & van Kuppeveld, F. J. M. (2014). Induction and suppression of innate antiviral responses by picornaviruses. Cytokine & growth factor reviews, 25(5), 577-585. https://doi.org/10.1016/j.cytogfr.2014.07.003
Galama, J. M. D., Zoll, J. G., Lanke, K. H., de Jong, A. S., Melief, J., Huitinga, I., Verbeek, M. M., & van Kuppeveld, F. J. M. (2014). Saffold cardiovirus and multiple sclerosis: no evidence for an association. Annals of Clinical and Translational Neurology, 1(8), 618-21. https://doi.org/10.1002/acn3.82
Roulin, P. S., Lötzerich, M., Torta, F., Tanner, L. B., van Kuppeveld, F. J. M., Wenk, M. R., & Greber, U. F. (2014). Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. Cell Host & Microbe, 16(5), 677-90. https://doi.org/10.1016/j.chom.2014.10.003
Dorobantu, C. M., Ford-Siltz, L. A., Sittig, S. P., Lanke, K. H. W., Belov, G. A., van Kuppeveld, F. J. M., & van der Schaar, H. M. (2014). GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins. Journal of Virology. https://doi.org/10.1128/JVI.02830-14
Burkard, C., Bloyet, L. M., Wicht, O., Van Kuppeveld, F. J., Rottier, P. J. M., De Haan, C. A. M., & Bosch, B. J. (2014). Dissecting virus entry: Replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase. PLoS One, 9(7), Article e101762. https://doi.org/10.1371/journal.pone.0101762
Dorobantu, C. M., van der Schaar, H. M., Ford, L. A., Strating, J. R. P. M., Ulferts, R., Fang, Y., Belov, G., & van Kuppeveld, F. J. M. (2014). Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1. Journal of Virology, 88(5), 2725-2736. https://doi.org/10.1128/JVI.03650-13
Wicht, O., Burkard, C., de Haan, C. A. M., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell. Journal of Virology, 88(9), 4943-4952. https://doi.org/10.1128/JVI.03451-13
Burkard, C., Verheije, M. H., Wicht, O., van Kasteren, S. I., van Kuppeveld, F. J., Haagmans, B. L., Pelkmans, L., Rottier, P. J. M., Bosch, B. J., & de Haan, C. A. M. (2014). Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner. PLoS Pathogens, 10(11), Article e1004502. https://doi.org/10.1371/journal.ppat.1004502
Wicht, O., Li, W., Willems, L., Meuleman, T. J., Wubbolts, R. W., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture. Journal of Virology, 88(14), 7952-7961. https://doi.org/10.1128/JVI.00297-14
Langereis, M. A., Feng, Q., Nelissen, F. H. T., Virgen-Slane, R., van der Heden van Noort, G. J., Maciejewski, S., Filippov, D. V., Semler, B. L., van Delft, F. L., & van Kuppeveld, F. J. M. (2014). Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA. Nucleic Acids Research, 42(4), 2473-2482. https://doi.org/10.1093/nar/gkt1162

2013

Scholarly publications

Li, C., Li, Z., Zou, Y., Wicht, O., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2013). Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination. PLoS One, 8(8), Article e69997. https://doi.org/10.1371/journal.pone.0069997
Mou, H., Stalin Raj, V., van Kuppeveld, F. J. M., Rottier, P. J. M., Haagmans, B. L., & Bosch, B. J. (2013). The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies. Journal of Virology, 87(16), 9379-9383. https://doi.org/10.1128/JVI.01277-13
Seehafer, K., Rominger, F., Helmchen, G., Langhans, M., Robinson, D. G., Özata, B., Brügger, B., Strating, J. R. P. M., van Kuppeveld, F. J. M., & Klein, C. D. (2013). Synthesis and Biological Properties of Novel Brefeldin A Analogues. Journal of Medicinal Chemistry, 56(14), 5872-5884. https://doi.org/10.1021/jm400615g
de Vries, R. P., de Vries, E., Martínez-Romero, C., McBride, R., van Kuppeveld, F. J. M., Rottier, P. J. M., García-Sastre, A., Paulson, J. C., & de Haan, C. A. M. (2013). Evolution of the Hemagglutinin Protein of the New Pandemic H1N1 Influenza Virus: Maintaining Optimal Receptor Binding by Compensatory Substitutions. Journal of Virology, 87(24), 13868-13877. https://doi.org/10.1128/JVI.01955-13
Schulte, B. M., Kers-Rebel, E. D., Prosser, A. C., Galama, J. M. D., van Kuppeveld, F. J. M., & Adema, G. J. (2013). Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different enteroviruses. PLoS One, 8(4). https://doi.org/10.1371/journal.pone.0062502
van Cleef, K., Overheul, G., Thomassen, M., Kaptein, S., Davidson, A., Jacobs, M., Neyts, J., van Kuppeveld, F. J. M., & van Rij, R. (2013). Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Research, 99, 165-171.
Dortmans, J. C. F. M., Dekkers, J., Ambepitiya Wickramasinghe, I. N., Verheije, M. H., Rottier, P. J. M., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2013). Adaptation of novel H7N9 influenza A virus to human receptors. Scientific Reports, 3, 3058. https://doi.org/10.1038/srep03058
Triantafilou, K., Kar, S., van Kuppeveld, F. J. M., & Triantafilou, M. (2013). Rhinovirus induced calcium flux triggers NLRP3 and NLRC5 inflammasome activation. American Journal of Respiratory Cell and Molecular Biology, 49(6), 923-934. https://doi.org/10.1165/rcmb.2013-0032OC
van der Schaar, H. M., Leyssen, P., Thibaut, H. J., de Palma, A., van der Linden, L., Lanke, K. H. W., Lacroix, C., Verbeken, E., Conrath, K., Macleod, A. M., Mitchell, D. R., Palmer, N. J., van de Poël, H., Andrews, M., Neyts, J., & van Kuppeveld, F. J. M. (2013). A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ. Antimicrobial Agents and Chemotherapy, 57(10), 4971-4981. https://doi.org/10.1128/AAC.01175-13
Langereis, M. A., Feng, Q., & van Kuppeveld, F. J. M. (2013). MDA5 localizes to stress granules, but this localization is not required for the induction of type I Interferon. Journal of Virology, 87(11), 6314-6325. https://doi.org/10.1128/JVI.03213-12
Strating, J. R. P. M., van der Schaar, H. M., & van Kuppeveld, F. J. M. (2013). Cholesterol: fa(s)t-food for enterovirus genome replication. Trends in Microbiology, 21(11), 560-561. https://doi.org/10.1016/j.tim.2013.09.007
Ulferts, R., Thibaut, H. J., Lanke, K. H. W., Leyssen, P., Coutard, B., De Palma, A. M., Canard, B., Neyts, J., & van Kuppeveld, F. J. M. (2013). Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enterovirus B and D by targeting viral protein 2C. Antimicrobial Agents and Chemotherapy, 57(4), 1952-1956. https://doi.org/10.1128/AAC.02084-12

2012

Scholarly publications

van Kuppeveld, F. J. M., & van der Meer, J. W. M. (2012). XMRV and CFS--the sad end of a story. The Lancet, 379(9814), e27-8. https://doi.org/10.1016/S0140-6736(11)60899-4
Schulte, B. M., Lanke, K. H. W., Piganelli, J. D., Kers-Rebel, E. D., Bottino, R., Trucco, M., Huijbens, R. J. F., Radstake, T. R. D. J., Engelse, M. A., de Koning, E. J. P., Galama, J. M., Adema, G. J., & van Kuppeveld, F. J. M. (2012). Cytokine and chemokine production by human pancreatic islets upon enterovirus infection. Diabetes, 61(8), 2030-6. https://doi.org/10.2337/db11-1547
Feng, Q., Hato, S. V., Langereis, M. A., Zoll, J., Virgen-Slane, R., Peisley, A., Hur, S., Semler, B. L., van Rij, R. P., & van Kuppeveld, F. J. M. (2012). MDA5 Detects the Double-Stranded RNA Replicative Form in Picornavirus-Infected Cells. Cell Reports [E], 2(5), 1187-1196. https://doi.org/10.1016/j.celrep.2012.10.005
van der Schaar, H. M., van der Linden, L., Lanke, K. H. W., Strating, J. R. P. M., Pürstinger, G., de Vries, E., de Haan, C. A. M., Neyts, J., & van Kuppeveld, F. J. M. (2012). Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication. Cell Research, 22(11), 1576-1592. https://doi.org/10.1038/cr.2012.129
Belov, G. A., & van Kuppeveld, F. J. M. (2012). (+)RNA viruses rewire cellular pathways to build replication. Current Opinion in Virology, 2, 740-747. https://doi.org/10.1016/j.coviro.2012.09.006

2011

Scholarly publications

Galama, J., Lanke, K., Zoll, J., Roivainen, M., & van Kuppeveld, F. (2011). Seroepidemiology of Saffold cardiovirus type 2. Emerging Infectious Diseases, 17(8), 1572-3. https://doi.org/10.3201/eid1708.101953
Zoll, J., Hahn, M. M., Gielen, P., Heus, H. A., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2011). Unusual loop-sequence flexibility of the proximal RNA replication element in EMCV. PLoS One, 6(9), e24818. https://doi.org/10.1371/journal.pone.0024818
Limpens, R. W. A. L., van der Schaar, H. M., Kumar, D., Koster, A. J., Snijder, E. J., van Kuppeveld, F. J. M., & Bárcena, M. (2011). The transformation of enterovirus replication structures: a three-dimensional study of single- and double-membrane compartments. MBio [E], 2(5). https://doi.org/10.1128/mBio.00166-11

2010

Scholarly publications

Hato, S. V., Sorgeloos, F., Ricour, C., Zoll, J., Melchers, W. J. G., Michiels, T., & van Kuppeveld, F. J. M. (2010). Differential IFN-alpha/beta production suppressing capacities of the leader proteins of mengovirus and foot-and-mouth disease virus. Cellular Microbiology, 12(3), 310-7. https://doi.org/10.1111/j.1462-5822.2009.01395.x
Schulte, B. M., Kramer, M., Ansems, M., Lanke, K. H. W., van Doremalen, N., Piganelli, J. D., Bottino, R., Trucco, M., Galama, J. M. D., Adema, G. J., & van Kuppeveld, F. J. M. (2010). Phagocytosis of enterovirus-infected pancreatic beta-cells triggers innate immune responses in human dendritic cells. Diabetes, 59(5), 1182-91. https://doi.org/10.2337/db09-1071
Schulte, B. M., Bakkers, J., Lanke, K. H. W., Melchers, W. J. G., Westerlaken, C., Allebes, W., Aanstoot, H.-J., Bruining, G. J., Adema, G. J., Van Kuppeveld, F. J. M., & Galama, J. M. D. (2010). Detection of enterovirus RNA in peripheral blood mononuclear cells of type 1 diabetic patients beyond the stage of acute infection. Viral Immunology, 23(1), 99-104. https://doi.org/10.1089/vim.2009.0072
van Kuppeveld, F. J. M., de Jong, A. S., Lanke, K. H., Verhaegh, G. W., Melchers, W. J. G., Swanink, C. M. A., Bleijenberg, G., Netea, M. G., Galama, J. M. D., & van der Meer, J. W. M. (2010). Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort. BMJ - Clinical research, 340, c1018.
Kramer, M., Schulte, B. M., Eleveld-Trancikova, D., van Hout-Kuijer, M., Toonen, L. W. J., Tel, J., de Vries, I. J. M., van Kuppeveld, F. J. M., Jansen, B. J. H., & Adema, G. J. (2010). Cross-talk between human dendritic cell subsets influences expression of RNA sensors and inhibits picornavirus infection. Journal of Innate Immunity, 2(4), 360-70. https://doi.org/10.1159/000300568
van der Meer, J. W. M., Netea, M. G., Galama, J. M. D., & van Kuppeveld, F. J. M. (2010). Comment on "Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome". Science, 328(5980), 825; author reply 825. https://doi.org/10.1126/science.1183906
van der Linden, L., van der Schaar, H. M., Lanke, K. H. W., Neyts, J., & van Kuppeveld, F. J. M. (2010). Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. Journal of Virology, 84(15), 7535-42. https://doi.org/10.1128/JVI.02684-09
Hsu, N.-Y., Ilnytska, O., Belov, G., Santiana, M., Chen, Y.-H., Takvorian, P. M., Pau, C., van der Schaar, H., Kaushik-Basu, N., Balla, T., Cameron, C. E., Ehrenfeld, E., van Kuppeveld, F. J. M., & Altan-Bonnet, N. (2010). Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell, 141(5), 799-811. https://doi.org/10.1016/j.cell.2010.03.050

2009

Scholarly publications

Zoll, J., Heus, H. A., van Kuppeveld, F. J. M., & Melchers, W. J. G. (2009). The structure-function relationship of the enterovirus 3'-UTR. Virus Research, 139(2), 209-16. https://doi.org/10.1016/j.virusres.2008.07.014
Krenn, B. M., Gaudernak, E., Holzer, B., Lanke, K., Van Kuppeveld, F. J. M., & Seipelt, J. (2009). Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. Journal of Virology, 83(1), 58-64. https://doi.org/10.1128/JVI.01543-08
Ricour, C., Delhaye, S., Hato, S. V., Olenyik, T. D., Michel, B., van Kuppeveld, F. J. M., Gustin, K. E., & Michiels, T. (2009). Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein. Journal of General Virology, 90(Pt 1), 177-86. https://doi.org/10.1099/vir.0.005678-0
Bardina, M. V., Lidsky, P. V., Sheval, E. V., Fominykh, K. V., van Kuppeveld, F. J. M., Polyakov, V. Y., & Agol, V. I. (2009). Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machinery. Journal of Virology, 83(7), 3150-61. https://doi.org/10.1128/JVI.01456-08
Duijsings, D., Lanke, K. H. W., van Dooren, S. H. J., van Dommelen, M. M. T., Wetzels, R., de Mattia, F., Wessels, E., & van Kuppeveld, F. J. M. (2009). Differential membrane association properties and regulation of class I and class II Arfs. Traffic, 10(3), 316-23. https://doi.org/10.1111/j.1600-0854.2008.00868.x
Zoll, J., Galama, J. M. D., & van Kuppeveld, F. J. M. (2009). Identification of potential recombination breakpoints in human parechoviruses. Journal of Virology, 83(7), 3379-83. https://doi.org/10.1128/JVI.02529-08
De Palma, A. M., Thibaut, H. J., van der Linden, L., Lanke, K., Heggermont, W., Ireland, S., Andrews, R., Arimilli, M., Al-Tel, T. H., De Clercq, E., van Kuppeveld, F., & Neyts, J. (2009). Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrobial Agents and Chemotherapy, 53(5), 1850-7. https://doi.org/10.1128/AAC.00934-08
Zoll, J., Erkens Hulshof, S., Lanke, K., Verduyn Lunel, F., Melchers, W. J. G., Schoondermark-van de Ven, E., Roivainen, M., Galama, J. M. D., & van Kuppeveld, F. J. M. (2009). Saffold virus, a human Theiler's-like cardiovirus, is ubiquitous and causes infection early in life. PLoS Pathogens, 5(5), e1000416. https://doi.org/10.1371/journal.ppat.1000416
Romanova, L. I., Lidsky, P. V., Kolesnikova, M. S., Fominykh, K. V., Gmyl, A. P., Sheval, E. V., Hato, S. V., van Kuppeveld, F. J. M., & Agol, V. I. (2009). Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein. Journal of Virology, 83(14), 7273-84. https://doi.org/10.1128/JVI.00467-09
de Mattia, F., Gubser, C., van Dommelen, M. M. T., Visch, H.-J., Distelmaier, F., Postigo, A., Luyten, T., Parys, J. B., de Smedt, H., Smith, G. L., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2009). Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. Molecular Biology of the Cell, 20(16), 3638-45. https://doi.org/10.1091/mbc.E09-05-0385
Lidsky, P. V., Romanova, L. I., Kolesnikova, M. S., Bardina, M. V., Khitrina, E. V., Hato, S. V., van Kuppeveld, F. J. M., & Agol, V. I. (2009). Interactions between viral and prokaryotic pathogens in a mixed infection with cardiovirus and mycoplasma. Journal of Virology, 83(19), 9940-51. https://doi.org/10.1128/JVI.01167-09
Ricour, C., Borghese, F., Sorgeloos, F., Hato, S. V., van Kuppeveld, F. J. M., & Michiels, T. (2009). Random mutagenesis defines a domain of Theiler's virus leader protein that is essential for antagonism of nucleocytoplasmic trafficking and cytokine gene expression. Journal of Virology, 83(21), 11223-32. https://doi.org/10.1128/JVI.00829-09
Lanke, K. H. W., van der Schaar, H. M., Belov, G. A., Feng, Q., Duijsings, D., Jackson, C. L., Ehrenfeld, E., & van Kuppeveld, F. J. M. (2009). GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication. Journal of Virology, 83(22), 11940-9. https://doi.org/10.1128/JVI.01244-09

2008

Scholarly publications

Kramer, M., Schulte, B. M., Toonen, L. W. J., Barral, P. M., Fisher, P. B., Lanke, K. H. W., Galama, J. M. D., van Kuppeveld, F. J. M., & Adema, G. J. (2008). Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells. Journal of Virology, 82(6), 2930-7. https://doi.org/10.1128/JVI.02376-07
de Jong, A. S., de Mattia, F., Van Dommelen, M. M., Lanke, K., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2008). Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking. Journal of Virology, 82(7), 3782-90. https://doi.org/10.1128/JVI.02076-07
de Vries, W., Haasnoot, J., van der Velden, J., van Montfort, T., Zorgdrager, F., Paxton, W., Cornelissen, M., van Kuppeveld, F., de Haan, P., & Berkhout, B. (2008). Increased virus replication in mammalian cells by blocking intracellular innate defense responses. Gene Therapy, 15(7), 545-52. https://doi.org/10.1038/gt.2008.12
De Palma, A. M., Heggermont, W., Lanke, K., Coutard, B., Bergmann, M., Monforte, A.-M., Canard, B., De Clercq, E., Chimirri, A., Pürstinger, G., Rohayem, J., van Kuppeveld, F., & Neyts, J. (2008). The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. Journal of Virology, 82(10), 4720-30. https://doi.org/10.1128/JVI.01338-07
Verheije, M. H., Raaben, M., Mari, M., Te Lintelo, E. G., Reggiori, F., van Kuppeveld, F. J. M., Rottier, P. J. M., & de Haan, C. A. M. (2008). Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. PLoS Pathogens, 4(6), Article e1000088. https://doi.org/10.1371/journal.ppat.1000088

2007

Scholarly publications

Kramer, M., Schulte, B. M., Toonen, L. W. J., de Bruijni, M. A. M., Galama, J. M. D., Adema, G. J., & van Kuppeveld, F. J. M. (2007). Echovirus infection causes rapid loss-of-function and cell death in human dendritic cells. Cellular Microbiology, 9(6), 1507-18. https://doi.org/10.1111/j.1462-5822.2007.00888.x
Gubser, C., Bergamaschi, D., Hollinshead, M., Lu, X., van Kuppeveld, F. J. M., & Smith, G. L. (2007). A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathogens, 3(2), e17. https://doi.org/10.1371/journal.ppat.0030017
Wessels, E., Duijsings, D., Lanke, K. H. W., Melchers, W. J. G., Jackson, C. L., & van Kuppeveld, F. J. M. (2007). Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1. Journal of Virology, 81(10), 5238-45. https://doi.org/10.1128/JVI.02680-06
Lanke, K., Krenn, B. M., Melchers, W. J. G., Seipelt, J., & van Kuppeveld, F. J. M. (2007). PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells. Journal of General Virology, 88(Pt 4), 1206-17. https://doi.org/10.1099/vir.0.82634-0
Zoll, J., Tessari, M., Van Kuppeveld, F. J. M., Melchers, W. J. G., & Heus, H. A. (2007). Breaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairs. RNA, 13(5), 781-92. https://doi.org/10.1261/rna.375607
Duijsings, D., Wessels, E., van Emst-de Vries, S. E., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2007). Reduction of phospholipase D activity during coxsackievirus infection. Journal of General Virology, 88(Pt 11), 3027-30. https://doi.org/10.1099/vir.0.83169-0
Hato, S. V., Ricour, C., Schulte, B. M., Lanke, K. H. W., de Bruijni, M., Zoll, J., Melchers, W. J. G., Michiels, T., & van Kuppeveld, F. J. M. (2007). The mengovirus leader protein blocks interferon-alpha/beta gene transcription and inhibits activation of interferon regulatory factor 3. Cellular Microbiology, 9(12), 2921-30. https://doi.org/10.1111/j.1462-5822.2007.01006.x

2006

Scholarly publications

van Ooij, M. J. M., Vogt, D. A., Paul, A., Castro, C., Kuijpers, J., van Kuppeveld, F. J. M., Cameron, C. E., Wimmer, E., Andino, R., & Melchers, W. J. G. (2006). Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. Journal of General Virology, 87(Pt 1), 103-13. https://doi.org/10.1099/vir.0.81297-0
van Ooij, M. J. M., Glaudemans, D. H. R. F., Heus, H. A., van Kuppeveld, F. J. M., & Melchers, W. J. G. (2006). Structural and functional integrity of the coxsackievirus B3 oriR: spacing between coaxial RNA helices. Journal of General Virology, 87(Pt 3), 689-95. https://doi.org/10.1099/vir.0.81558-0
Lidsky, P. V., Hato, S., Bardina, M. V., Aminev, A. G., Palmenberg, A. C., Sheval, E. V., Polyakov, V. Y., van Kuppeveld, F. J. M., & Agol, V. I. (2006). Nucleocytoplasmic traffic disorder induced by cardioviruses. Journal of Virology, 80(6), 2705-17. https://doi.org/10.1128/JVI.80.6.2705-2717.2006
de Jong, A. S., Visch, H.-J., de Mattia, F., van Dommelen, M. M., Swarts, H. G., Luyten, T., Callewaert, G., Melchers, W. J., Willems, P. H., & van Kuppeveld, F. J. (2006). The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi. Journal of Biological Chemistry, 281(20), 14144-50. https://doi.org/10.1074/jbc.M511766200
Visch, H.-J., Koopman, W. J. H., Zeegers, D., van Emst-de Vries, S. E., van Kuppeveld, F. J. M., van den Heuvel, L. W. P. J., Smeitink, J. A. M., & Willems, P. H. G. M. (2006). Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency. American Journal of Physiology-Cell Physiology, 291(2), C308-16. https://doi.org/10.1152/ajpcell.00561.2005
van Ooij, M. J. M., Polacek, C., Glaudemans, D. H. R. F., Kuijpers, J., van Kuppeveld, F. J. M., Andino, R., Agol, V. I., & Melchers, W. J. G. (2006). Polyadenylation of genomic RNA and initiation of antigenomic RNA in a positive-strand RNA virus are controlled by the same cis-element. Nucleic Acids Research, 34(10), 2953-65. https://doi.org/10.1093/nar/gkl349
Wessels, E., Notebaart, R. A., Duijsings, D., Lanke, K., Vergeer, B., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). Structure-function analysis of the coxsackievirus protein 3A: identification of residues important for dimerization, viral rna replication, and transport inhibition. Journal of Biological Chemistry, 281(38), 28232-43. https://doi.org/10.1074/jbc.M601122200
Wessels, E., Duijsings, D., Lanke, K. H. W., van Dooren, S. H. J., Jackson, C. L., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment. Journal of Virology, 80(23), 11852-60. https://doi.org/10.1128/JVI.01225-06
Wessels, E., Duijsings, D., Niu, T.-K., Neumann, S., Oorschot, V. M., de Lange, F., Lanke, K. H. W., Klumperman, J., Henke, A., Jackson, C. L., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1. Developmental Cell, 11(2), 191-201. https://doi.org/10.1016/j.devcel.2006.06.005

2005

Scholarly publications

van Kuppeveld, F. J. M., de Jong, A. S., Melchers, W. J. G., & Willems, P. H. G. M. (2005). Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive? Trends in Microbiology, 13(2), 41-4. https://doi.org/10.1016/j.tim.2004.12.005
Saelens, X., Festjens, N., Parthoens, E., Vanoverberghe, I., Kalai, M., van Kuppeveld, F., & Vandenabeele, P. (2005). Protein synthesis persists during necrotic cell death. Journal of Cell Biology, 168(4), 545-51. https://doi.org/10.1083/jcb.200407162
Wessels, E., Duijsings, D., Notebaart, R. A., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2005). A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-golgi transport. Journal of Virology, 79(8), 5163-73. https://doi.org/10.1128/JVI.79.8.5163-5173.2005
Krenn, B. M., Holzer, B., Gaudernak, E., Triendl, A., van Kuppeveld, F. J., & Seipelt, J. (2005). Inhibition of polyprotein processing and RNA replication of human rhinovirus by pyrrolidine dithiocarbamate involves metal ions. Journal of Virology, 79(22), 13892-9. https://doi.org/10.1128/JVI.79.22.13892-13899.2005
Bopegamage, S., Kovacova, J., Vargova, A., Motusova, J., Petrovicova, A., Benkovicova, M., Gomolcak, P., Bakkers, J., van Kuppeveld, F., Melchers, W. J. G., & Galama, J. M. (2005). Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection. Journal of General Virology, 86(Pt 12), 3271-80. https://doi.org/10.1099/vir.0.81249-0

2004

Scholarly publications

Campanella, M., de Jong, A. S., Lanke, K. W. H., Melchers, W. J. G., Willems, P. H. G. M., Pinton, P., Rizzuto, R., & van Kuppeveld, F. J. M. (2004). The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. Journal of Biological Chemistry, 279(18), 18440-50. https://doi.org/10.1074/jbc.M309494200
de Jong, A. S., Melchers, W. J. G., Glaudemans, D. H. R. F., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2004). Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication. Journal of Biological Chemistry, 279(19), 19924-35. https://doi.org/10.1074/jbc.M314094200

2003

Scholarly publications

de Jong, A. S., Wessels, E., Dijkman, H. B. P. M., Galama, J. M. D., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2003). Determinants for membrane association and permeabilization of the coxsackievirus 2B protein and the identification of the Golgi complex as the target organelle. Journal of Biological Chemistry, 278(2), 1012-21. https://doi.org/10.1074/jbc.M207745200
Lescrinier, E. M. H. P., Tessari, M., van Kuppeveld, F. J. M., Melchers, W. J. G., Hilbers, C. W., & Heus, H. A. (2003). Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs. Journal of Molecular Biology, 331(4), 759-69.

2002

Scholarly publications

Merkle, I., van Ooij, M. J. M., van Kuppeveld, F. J. M., Glaudemans, D. H. R. F., Galama, J. M. D., Henke, A., Zell, R., & Melchers, W. J. G. (2002). Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region. Journal of Virology, 76(19), 9900-9.
van Kuppeveld, F. J. M., de Jong, A., Dijkman, H. B. P. M., Andino, R., & Melchers, W. J. G. (2002). Studies towards the potential of poliovirus as a vector for the expression of HPV 16 virus-like-particles. FEMS Immunology and Medical Microbiology, 34(3), 201-8.
Zoll, J., Melchers, W. J. G., Galama, J. M. D., & van Kuppeveld, F. J. M. (2002). The mengovirus leader protein suppresses alpha/beta interferon production by inhibition of the iron/ferritin-mediated activation of NF-kappa B. Journal of Virology, 76(19), 9664-72.
van Kuppeveld, F. J. M., Melchers, W. J. G., Willems, P. H. G. M., & Gadella, T. W. J. (2002). Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy. Journal of Virology, 76(18), 9446-56.
de Jong, A. S., Schrama, I. W. J., Willems, P. H. G. M., Galama, J. M. D., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2002). Multimerization reactions of coxsackievirus proteins 2B, 2C and 2BC: a mammalian two-hybrid analysis. Journal of General Virology, 83(Pt 4), 783-93.
van Kuppeveld, F. J. M., van den Hurk, P. J. J. C., Schrama, I. W. J., Galama, J. M. D., & Melchers, W. J. G. (2002). Trans-complementation of a genetic defect in the coxsackie B3 virus 2B protein. Journal of General Virology, 83(Pt 2), 341-50.

1998

Scholarly publications

Zoll, J., van Kuppeveld, F. J., Galama, J. M., & Melchers, W. J. (1998). Genetic analysis of mengovirus protein 2A: its function in polyprotein processing and virus reproduction. Journal of General Virology, 79 ( Pt 1), 17-25.
Van Horssen, A. M., Van Kuppeveld, F. J., & Martens, G. J. (1998). Manipulation of disulfide bonds differentially affects the intracellular transport, sorting, and processing of neuroendocrine secretory proteins. Journal of Neurochemistry, 71(1), 402-9.

1997

Scholarly publications

Van kuppeveld, F. J., Melchers, W. J., Kirkegaard, K., & Doedens, J. R. (1997). Structure-function analysis of coxsackie B3 virus protein 2B. Virology, 227(1), 111-8. https://doi.org/10.1006/viro.1996.8320
van Kuppeveld, F. J., Hoenderop, J. G., Smeets, R. L., Willems, P. H., Dijkman, H. B., Galama, J. M., & Melchers, W. J. (1997). Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release. EMBO Journal, 16(12), 3519-32. https://doi.org/10.1093/emboj/16.12.3519
van Kuppeveld, F. J., van den Hurk, P. J., van der Vliet, W., Galama, J. M., & Melchers, W. J. (1997). Chimeric coxsackie B3 virus genomes that express hybrid coxsackievirus-poliovirus 2B proteins: functional dissection of structural domains involved in RNA replication. Journal of General Virology, 78 ( Pt 8), 1833-40.
van Kuppeveld, F. J., van Horssen, A. M., & Martens, G. J. (1997). Intracellular transport, sorting, and proteolytic processing of regulated secretory proteins does not require protein sulfation. Molecular and Cellular Endocrinology, 136(1), 29-35.

1996

Scholarly publications

van Kuppeveld, F., van der Logt, J., Johansson, K. E., & Melchers, W. (1996). Demonstration of Mycoplasma contamination in cell cultures by a Mycoplasma group- specific polymerase chain reaction. Methods, 2, 525-38. https://doi.org/10.1385/0-89603-335-X:525
van Kuppeveld, F. J., Galama, J. M., Zoll, J., van den Hurk, P. J., & Melchers, W. J. (1996). Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication. Journal of Virology, 70(6), 3876-86.
Zoll, J., Galama, J. M., van Kuppeveld, F. J., & Melchers, W. J. (1996). Mengovirus leader is involved in the inhibition of host cell protein synthesis. Journal of Virology, 70(8), 4948-52.
van Kuppeveld, F. J., van den Hurk, P. J., Zoll, J., Galama, J. M., & Melchers, W. J. (1996). Mutagenesis of the coxsackie B3 virus 2B/2C cleavage site: determinants of processing efficiency and effects on viral replication. Journal of Virology, 70(11), 7632-40.

1995

Scholarly publications

van Kuppeveld, F. J., Galama, J. M., Zoll, J., & Melchers, W. J. (1995). Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis. Journal of Virology, 69(12), 7782-90.

1994

Scholarly publications

Tjhie, J. H., van Kuppeveld, F. J., Roosendaal, R., Melchers, W. J., Gordijn, R., MacLaren, D. M., Walboomers, J. M., Meijer, C. J., & van den Brule, A. J. (1994). Direct PCR enables detection of Mycoplasma pneumoniae in patients with respiratory tract infections. Journal of Clinical Microbiology, 32(1), 11-6.
van Kuppeveld, F. J., Johansson, K. E., Galama, J. M., Kissing, J., Bölske, G., van der Logt, J. T., & Melchers, W. J. (1994). Detection of mycoplasma contamination in cell cultures by a mycoplasma group-specific PCR. Applied and Environmental Microbiology, 60(1), 149-52.
van Kuppeveld, F., Melchers, W., Kissing, J., van der Logt, J., & Galama, J. (1994). No evidence of mycoplasmas in peripheral blood mononuclear cell fraction of HIV-infected patients. Infection, 22(3), 204-6.
van Kuppeveld, F. J., Johansson, K. E., Galama, J. M., Kissing, J., Bölske, G., Hjelm, E., van der Logt, J. T., & Melchers, W. J. (1994). 16S rRNA based polymerase chain reaction compared with culture and serological methods for diagnosis of Mycoplasma pneumoniae infection. European Journal of Clinical Microbiology & Infectious Diseases, 13(5), 401-5.

1993

Scholarly publications

Zoll, J., Jongen, P., Galama, J., van Kuppeveld, F., & Melchers, W. (1993). Coxsackievirus B1-induced murine myositis: no evidence for viral persistence. Journal of General Virology, 74 ( Pt 10), 2071-6.
van Kuppeveld, F. J., Melchers, W. J., Willemse, H. F., Kissing, J., Galama, J. M., & van der Logt, J. T. (1993). Detection of Mycoplasma pulmonis in experimentally infected laboratory rats by 16S rRNA amplification. Journal of Clinical Microbiology, 31(3), 524-7.
van Kuppeveld, F. J., van der Logt, J. T., Angulo, A. F., van Zoest, M. J., Quint, W. G., Niesters, H. G., Galama, J. M., & Melchers, W. J. (1993). Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification. Applied and Environmental Microbiology, 59(2), 655.

1992

Scholarly publications

van Kuppeveld, F. J., van der Logt, J. T., Angulo, A. F., van Zoest, M. J., Quint, W. G., Niesters, H. G., Galama, J. M., & Melchers, W. J. (1992). Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification. Applied and Environmental Microbiology, 58(8), 2606-15.
Meis, J. F., van Kuppeveld, F. J., Kremer, J. A., Nijhuis, J. G., & Melchers, W. J. (1992). Fatal intrauterine infection associated with Mycoplasma hominis. Clinical Infectious Diseases, 15(4), 753-4.