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Kint, J., Langereis, M. A., Maier, H. J., Britton, P., van Kuppeveld, F. J., Koumans, J., Wiegertjes, G. F., & Forlenza, M. (2016). Infectious bronchitis coronavirus limits interferon production by inducing a host shutoff that requires accessory protein 5b. Journal of Virology, 90(16), 7519-7528. https://doi.org/10.1128/JVI.00627-16

Mullapudi, E., Nováček, J., Pálková, L., Kulich, P., Lindberg, A. M., van Kuppeveld, F. J. M., & Plevka, P. (2016). Structure and genome release mechanism of human cardiovirus Saffold virus-3. Journal of Virology, 90(17), 7628-7639. https://doi.org/10.1128/JVI.00746-16

Dorobantu, C. M., Albulescu, L., Lyoo, H., van Kampen, M., De Francesco, R., Lohmann, V., Harak, C., van der Schaar, H. M., Strating, J. R. P. M., Gorbalenya, A. E., & van Kuppeveld, F. J. M. (2016). Mutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding Protein. mSphere, 1(3), Article e00068-16. https://doi.org/10.1128/mSphere.00068-16

Li, W., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B.-J. (2016). Cellular entry of the porcine epidemic diarrhea virus. Virus Research, 226, 117-127. https://doi.org/10.1016/j.virusres.2016.05.031

Bakkers, M. J. G., Zeng, Q., Feitsma, L. J., Hulswit, R. J. G., Li, Z., Westerbeke, A., van Kuppeveld, F. J. M., Boons, G.-J., Langereis, M. A., Huizinga, E. G., & de Groot, R. J. (2016). Coronavirus receptor switch explained from the stereochemistry of protein-carbohydrate interactions and a single mutation. Proceedings of the National Academy of Sciences of the United States of America, 113(22), E3111-E3119. https://doi.org/10.1073/pnas.1519881113

van der Schaar, H. M., Dorobantu, C. M., Albulescu, L., Strating, J. R. P. M., & van Kuppeveld, F. J. M. (2016). Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles. Trends in Microbiology, 24(7), 535-546. https://doi.org/10.1016/j.tim.2016.02.017

Arts, P., van de Veerdonk, F. L., van der Lee, R., Langereis, M. A., Gilissen, C., van Zelst-Stams, W. A. G., Huynen, M. A., van der Meer, J. W. M., van Kuppeveld, F. J., Veltman, J. A., Kullberg, B. J., Hoischen, A., & Netea, M. G. (2016). Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy. Journal of Allergy and Clinical Immunology, 138(3), 895-898. https://doi.org/10.1016/j.jaci.2016.02.025

Humoud, M. N., Doyle, N., Royall, E., Willcocks, M. M., Sorgeloos, F., van Kuppeveld, F., Roberts, L. O., Goodfellow, I. G., Langereis, M. A., & Locker, N. (2016). Feline Calicivirus infection disrupts the assembly of cytoplasmic stress granules and induces G3BP1 cleavage. Journal of Virology, 90(14), 6489-6501. https://doi.org/10.1128/JVI.00647-16

Widjaja, I., Wicht, O., Luytjes, W., Leenhouts, K., Rottier, P. J. M., van Kuppeveld, F. J. M., Haijema, B. J., & de Haan, C. A. M. (2016). Characterization of epitope-specific anti-RSV antibody responses after natural infection and after vaccination with formalin-inactivated RSV. Journal of Virology, 90(13), 5965-5977. https://doi.org/10.1128/JVI.00235-16

Lardinois, C., Sorgeloos, F., Jacobs, S., van Kuppeveld, F. J. M., Kaspers, B., & Michiels, T. (2016). Neurotropism of Saffold virus in a mouse model. Journal of General Virology, 97, 1350-1355. https://doi.org/10.1099/jgv.0.000452

Ulferts, R., de Boer, M., van der Linden, L., Bauer, L., Lyoo, H. R., Maté, M. J., Lichière, J., Canard, B., Lelieveld, D., Omta, W., Egan, D., Coutard, B., & van Kuppeveld, F. J. M. (2016). Screening of a library of FDA-approved drugs identifies several enterovirus replicaton inhibitors that target viral protein 2C. Antimicrobial Agents and Chemotherapy, 60(5), 2627-2638. https://doi.org/10.1128/AAC.02182-15

Baglio, S. R., van Eijndhoven, M. A. J., Koppers-Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Léveillé, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., Verkuijlen, S. A. W. M., Scheffer, G. L., van Kuppeveld, F. J. M., de Gruijl, T. D., Bultink, I. E. M., Jordanova, E. S., Hackenberg, M., Piersma, S. R., Knol, J. C., ... Pegtel, D. M. (2016). Sensing of latent EBV infection through exosomal transfer of 5'pppRNA. Proceedings of the National Academy of Sciences of the United States of America, 113(5), E587-E597. https://doi.org/10.1073/pnas.1518130113

Baggen, J., Thibaut, H. J., Staring, J., Jae, L. T., Liu, Y., Guo, H., Slager, J. J., de Bruin, J. W., van Vliet, A. L. W., Blomen, V. A., Overduin, P., Sheng, J., de Haan, X., de Vries, E., Meijer, A., Rossmann, M. G., Brummelkamp, T. R., & van Kuppeveld, F. J. M. (2016). Enterovirus D68 receptor requirements unveiled by haploid genetics. Proceedings of the National Academy of Sciences of the United States of America, 113(5), 1399-1404. https://doi.org/10.1073/pnas.1524498113

Liu, Y., Sheng, J., Baggen, J., Meng, G., Xiao, C., Thibaut, H. J., van Kuppeveld, F. J. M., & Rossmann, M. G. (2015). Sialic acid-dependent cell entry of human enterovirus D68. Nature Communications [E], 6, Article 8865. https://doi.org/10.1038/ncomms9865

Kang, H., Kim, C., Kim, D.-E., Song, J.-H., Choi, M., Choi, K., Kang, M., Lee, K., Kim, H. S., Shin, J. S., Kim, J., Han, S.-B., Lee, M.-Y., Lee, S. U., Lee, C.-K., Kim, M., Ko, H.-J., van Kuppeveld, F. J. M., & Cho, S. (2015). Synergistic antiviral activity of gemcitabine and ribavirin against enteroviruses. Antiviral Research, 124, 1-10. https://doi.org/10.1016/j.antiviral.2015.10.011

van der Lee, R., Feng, Q., Langereis, M. A., Ter Horst, R., Szklarczyk, R., Netea, M. G., Andeweg, A. C., van Kuppeveld, F. J. M., & Huynen, M. A. (2015). Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response. PLoS Computational Biology, 11(10), Article e1004553. https://doi.org/10.1371/journal.pcbi.1004553

Dorobantu, C. M., Albulescu, L., Harak, C., Feng, Q., van Kampen, M., Strating, J. R. P. M., Gorbalenya, A. E., Lohmann, V., van der Schaar, H. M., & van Kuppeveld, F. J. M. (2015). Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C Virus. PLoS Pathogens, 11(9), Article e1005185. https://doi.org/10.1371/journal.ppat.1005185

Sun, L., Meijer, A., Froeyen, M., Zhang, L., Thibaut, H. J., Baggen, J., George, S., Vernachio, J., van Kuppeveld, F. J. M., Leyssen, P., Hilgenfeld, R., Neyts, J., & Delang, L. (2015). Antiviral activity of broad-spectrum and enterovirus-specific inhibitors against clinical isolates of enterovirus D68. Antimicrobial Agents and Chemotherapy, 59(12), 7782-7785. https://doi.org/10.1128/AAC.01375-15

Langereis, M. A., Rabouw, H. H., Holwerda, M., Visser, L. J., & van Kuppeveld, F. J. M. (2015). cGAS and STING knockout rescues virus infection of plasmid DNA-transfected cells. Journal of Virology, 89(21), 11169-11173. https://doi.org/10.1128/JVI.01781-15

Cancellieri, M., Bassetto, M., Widjaja, I., van Kuppeveld, F., de Haan, C. A. M., Brancale, A., & de Haan, C. A. M. (2015). In silico structure-based design and synthesis of novel anti-RSV compounds. Antiviral Research, 122, 46-50. https://doi.org/10.1016/j.antiviral.2015.08.003

Linden, L. V. D., Wolthers, K. C., & van Kuppeveld, F. J. M. (2015). Replication and Inhibitors of Enteroviruses and Parechoviruses. Viruses [E], 7(8), 4529-4562. https://doi.org/10.3390/v7082832

Widjaja, I., Rigter, A., Jacobino, S., van Kuppeveld, F. J. M., Leenhouts, K., Palomo, C., Melero, J. A., Leusen, J. H. W., Haijema, B. J., Rottier, P. J. M., & de Haan, C. A. M. (2015). Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics. PLoS One, 10(6), Article e0130829. https://doi.org/10.1371/journal.pone.0130829

Langereis, M. A., Bakkers, M. J. G., Deng, L., Padler-Karavani, V., Vervoort, S. J., Hulswit, R. J. G., van Vliet, A. L. W., Gerwig, G. J., de Poot, S. A. H., Boot, W., van Ederen, A. M., Heesters, B. A., van der Loos, C. M., van Kuppeveld, F. J. M., Yu, H., Huizinga, E. G., Chen, X., Varki, A., Kamerling, J. P., & de Groot, R. J. (2015). Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins. Cell Reports [E], 11(12), 1966-1978. https://doi.org/10.1016/j.celrep.2015.05.044

Li, W., Wicht, O., van Kuppeveld, F. J. M., He, Q., Rottier, P. J. M., & Bosch, B.-J. (2015). A single point mutation creating a furin cleavage site in the spike protein renders porcine epidemic diarrhea coronavirus trypsin-independent for cell entry and fusion. Journal of Virology, 89(15), 8077-8081. https://doi.org/10.1128/JVI.00356-15

de Vries, E., Guo, H., Dai, M., Rottier, P. J. M., van Kuppeveld, F. J. M., & de Haan, C. A. M. (2015). Rapid Emergence of Highly Pathogenic Avian Influenza Subtypes from a Subtype H5N1 Hemagglutinin Variant. Emerging Infectious Diseases, 21(5), 842-846. https://doi.org/10.3201/eid2105.141927

Schulte, B. M., Gielen, P. R., Kers-Rebel, E. D., Schreibelt, G., van Kuppeveld, F. J. M., & Adema, G. J. (2015). Enterovirus-Infected β-Cells Induce Distinct Response Patterns in BDCA1+ and BDCA3+ Human Dendritic Cells. PLoS One, 10(3), Article e0121670. https://doi.org/10.1371/journal.pone.0121670

Reineke, L. C., Kedersha, N., Langereis, M. A., van Kuppeveld, F. J. M., & Lloyd, R. E. (2015). Stress Granules Regulate Double-Stranded RNA-Dependent Protein Kinase Activation through a Complex Containing G3BP1 and Caprin1. MBio [E], 6(2), Article e02486-14 . https://doi.org/10.1128/mBio.02486-14

van der Linden, L., Vives-Adrián, L., Selisko, B., Ferrer-Orta, C., Liu, X., Lanke, K., Ulferts, R., De Palma, A. M., Tanchis, F., Goris, N., Lefebvre, D., De Clercq, K., Leyssen, P., Lacroix, C., Pürstinger, G., Coutard, B., Canard, B., Boehr, D. D., Arnold, J. J., ... van Kuppeveld, F. J. M. (2015). The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. PLoS Pathogens, 11(3), Article e1004733. https://doi.org/10.1371/journal.ppat.1004733

Albulescu, L., Strating, J. R. P. M., Thibaut, H. J., van der Linden, L., Shair, M. D., Neyts, J., & van Kuppeveld, F. J. M. (2015). Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP. Antiviral Research, 117, 110-114. https://doi.org/10.1016/j.antiviral.2015.02.013

Helms, B., Kaloyanova, D. V., Strating, J. R. P., van Hellemond, J. J., van der Schaar, H. M., Tielens, A. G. M., van Kuppeveld, F. J. M., & Brouwers, J. F. (2015). Targeting of the hydrophobic metabolome by pathogens. Traffic, 16(5), 439-460. https://doi.org/10.1111/tra.12280

Albulescu, L., Wubbolts, R., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2015). Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus. Cellular Microbiology, 17(8), 1144-1156. https://doi.org/10.1111/cmi.12425

Burkard, C., Verheije, M. H., Haagmans, B. L., van Kuppeveld, F. J., Rottier, P. J. M., Bosch, B.-J., & de Haan, C. A. M. (2015). ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. Journal of Virology, 89(8), 4434-4448. https://doi.org/10.1128/JVI.03274-14

Strating, J. R. P. M., van der Linden, L., Albulescu, L., Bigay, J., Arita, M., Delang, L., Leyssen, P., van der Schaar, H. M., Lanke, K. H. W., Thibaut, H. J., Ulferts, R., Drin, G., Schlinck, N., Wubbolts, R. W., Sever, N., Head, S. A., Liu, J. O., Beachy, P. A., De Matteis, M. A., ... van Kuppeveld, F. J. M. (2015). Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein. Cell Reports [E], 10(4), 600-615. https://doi.org/10.1016/j.celrep.2014.12.054

Thibaut, H. J., van der Schaar, H. M., Lanke, K. H. W., Verbeken, E., Andrews, M., Leyssen, P., Neyts, J., & van Kuppeveld, F. J. M. (2014). Fitness and virulence of a coxsackievirus mutant that can circumnavigate the need for phosphatidylinositol 4-kinase class III beta. Journal of Virology, 88(5), 3048-3051. https://doi.org/10.1128/JVI.03177-13

Feng, Q., Langereis, M. A., Lork, M., Nguyen, M., Hato, S. V., Lanke, K., Emdad, L., Bhoopathi, P., Fisher, P. B., Lloyd, R. E., & van Kuppeveld, F. J. M. (2014). Enterovirus 2Apro targets MDA5 and MAVS in infected cells. Journal of Virology, 88(6), 3369-3378. https://doi.org/10.1128/JVI.02712-13

van der Linden, L., Ulferts, R., Nabuurs, S. B., Kusov, Y., Liu, H., George, S., Lacroix, C., Goris, N., Lefebvre, D., Lanke, K. H. W., De Clercq, K., Hilgenfeld, R., Neyts, J., & van Kuppeveld, F. J. M. (2014). Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases. Antiviral Research, 103, 17-24. https://doi.org/10.1016/j.antiviral.2013.12.012

Vives-Adrian, L., Lujan, C., Oliva, B., van der Linden, L., Selisko, B., Coutard, B., Canard, B., van Kuppeveld, F. J. M., Ferrer-Orta, C., & Verdaguer, N. (2014). The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site. Journal of Virology, 88(10), 5595-5607. https://doi.org/10.1128/JVI.03502-13

Deddouche, S., Goubau, D., Rehwinkel, J., Chakravarty, P., Begum, S., Maillard, P. V., Borg, A., Matthews, N., Feng, Q., van Kuppeveld, F. J. M., & Reis e Sousa, C. (2014). Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells. eLife, 3, Article e01535. https://doi.org/10.7554/eLife.01535

Thibaut, H. J., van der Linden, L., Jiang, P., Thys, B., Canela, M.-D., Aguado, L., Rombaut, B., Wimmer, E., Paul, A., Pérez-Pérez, M.-J., van Kuppeveld, F. J. M., & Neyts, J. (2014). Binding of glutathione to enterovirus capsids is essential for virion morphogenesis. PLoS Pathogens, 10(4), e1004039. https://doi.org/10.1371/journal.ppat.1004039

Feng, Q., Langereis, M. A., Olagnier, D., Chiang, C., van de Winkel, R., van Essen, P., Zoll, J., Hiscott, J., & van Kuppeveld, F. J. M. (2014). Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation. PLoS One, 9(4), e95927. https://doi.org/10.1371/journal.pone.0095927

Feng, Q., Langereis, M. A., & van Kuppeveld, F. J. M. (2014). Induction and suppression of innate antiviral responses by picornaviruses. Cytokine & growth factor reviews, 25(5), 577-585. https://doi.org/10.1016/j.cytogfr.2014.07.003

Galama, J. M. D., Zoll, J. G., Lanke, K. H., de Jong, A. S., Melief, J., Huitinga, I., Verbeek, M. M., & van Kuppeveld, F. J. M. (2014). Saffold cardiovirus and multiple sclerosis: no evidence for an association. Annals of Clinical and Translational Neurology, 1(8), 618-21. https://doi.org/10.1002/acn3.82

Roulin, P. S., Lötzerich, M., Torta, F., Tanner, L. B., van Kuppeveld, F. J. M., Wenk, M. R., & Greber, U. F. (2014). Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. Cell Host & Microbe, 16(5), 677-90. https://doi.org/10.1016/j.chom.2014.10.003

Dorobantu, C. M., Ford-Siltz, L. A., Sittig, S. P., Lanke, K. H. W., Belov, G. A., van Kuppeveld, F. J. M., & van der Schaar, H. M. (2014). GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins. Journal of Virology. https://doi.org/10.1128/JVI.02830-14

Burkard, C., Bloyet, L. M., Wicht, O., Van Kuppeveld, F. J., Rottier, P. J. M., De Haan, C. A. M., & Bosch, B. J. (2014). Dissecting virus entry: Replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase. PLoS One, 9(7), Article e101762. https://doi.org/10.1371/journal.pone.0101762

Dorobantu, C. M., van der Schaar, H. M., Ford, L. A., Strating, J. R. P. M., Ulferts, R., Fang, Y., Belov, G., & van Kuppeveld, F. J. M. (2014). Recruitment of PI4KIIIβ to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1. Journal of Virology, 88(5), 2725-2736. https://doi.org/10.1128/JVI.03650-13

Wicht, O., Burkard, C., de Haan, C. A. M., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Identification and characterization of a proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell. Journal of Virology, 88(9), 4943-4952. https://doi.org/10.1128/JVI.03451-13

Burkard, C., Verheije, M. H., Wicht, O., van Kasteren, S. I., van Kuppeveld, F. J., Haagmans, B. L., Pelkmans, L., Rottier, P. J. M., Bosch, B. J., & de Haan, C. A. M. (2014). Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner. PLoS Pathogens, 10(11), Article e1004502. https://doi.org/10.1371/journal.ppat.1004502

Wicht, O., Li, W., Willems, L., Meuleman, T. J., Wubbolts, R. W., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture. Journal of Virology, 88(14), 7952-7961. https://doi.org/10.1128/JVI.00297-14

Langereis, M. A., Feng, Q., Nelissen, F. H. T., Virgen-Slane, R., van der Heden van Noort, G. J., Maciejewski, S., Filippov, D. V., Semler, B. L., van Delft, F. L., & van Kuppeveld, F. J. M. (2014). Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA. Nucleic Acids Research, 42(4), 2473-2482. https://doi.org/10.1093/nar/gkt1162

Li, C., Li, Z., Zou, Y., Wicht, O., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2013). Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination. PLoS One, 8(8), Article e69997. https://doi.org/10.1371/journal.pone.0069997

Mou, H., Stalin Raj, V., van Kuppeveld, F. J. M., Rottier, P. J. M., Haagmans, B. L., & Bosch, B. J. (2013). The Receptor Binding Domain of the New Middle East Respiratory Syndrome Coronavirus Maps to a 231-Residue Region in the Spike Protein That Efficiently Elicits Neutralizing Antibodies. Journal of Virology, 87(16), 9379-9383. https://doi.org/10.1128/JVI.01277-13

Seehafer, K., Rominger, F., Helmchen, G., Langhans, M., Robinson, D. G., Özata, B., Brügger, B., Strating, J. R. P. M., van Kuppeveld, F. J. M., & Klein, C. D. (2013). Synthesis and Biological Properties of Novel Brefeldin A Analogues. Journal of Medicinal Chemistry, 56(14), 5872-5884. https://doi.org/10.1021/jm400615g

de Vries, R. P., de Vries, E., Martínez-Romero, C., McBride, R., van Kuppeveld, F. J. M., Rottier, P. J. M., García-Sastre, A., Paulson, J. C., & de Haan, C. A. M. (2013). Evolution of the Hemagglutinin Protein of the New Pandemic H1N1 Influenza Virus: Maintaining Optimal Receptor Binding by Compensatory Substitutions. Journal of Virology, 87(24), 13868-13877. https://doi.org/10.1128/JVI.01955-13

Schulte, B. M., Kers-Rebel, E. D., Prosser, A. C., Galama, J. M. D., van Kuppeveld, F. J. M., & Adema, G. J. (2013). Differential susceptibility and response of primary human myeloid BDCA1(+) dendritic cells to infection with different enteroviruses. PLoS One, 8(4). https://doi.org/10.1371/journal.pone.0062502

van Cleef, K., Overheul, G., Thomassen, M., Kaptein, S., Davidson, A., Jacobs, M., Neyts, J., van Kuppeveld, F. J. M., & van Rij, R. (2013). Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication. Antiviral Research, 99, 165-171.

Dortmans, J. C. F. M., Dekkers, J., Ambepitiya Wickramasinghe, I. N., Verheije, M. H., Rottier, P. J. M., van Kuppeveld, F. J. M., de Vries, E., & de Haan, C. A. M. (2013). Adaptation of novel H7N9 influenza A virus to human receptors. Scientific Reports, 3, 3058. https://doi.org/10.1038/srep03058

Triantafilou, K., Kar, S., van Kuppeveld, F. J. M., & Triantafilou, M. (2013). Rhinovirus induced calcium flux triggers NLRP3 and NLRC5 inflammasome activation. American Journal of Respiratory Cell and Molecular Biology, 49(6), 923-934. https://doi.org/10.1165/rcmb.2013-0032OC

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Langereis, M. A., Feng, Q., & van Kuppeveld, F. J. M. (2013). MDA5 localizes to stress granules, but this localization is not required for the induction of type I Interferon. Journal of Virology, 87(11), 6314-6325. https://doi.org/10.1128/JVI.03213-12

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van der Linden, L., van der Schaar, H. M., Lanke, K. H. W., Neyts, J., & van Kuppeveld, F. J. M. (2010). Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. Journal of Virology, 84(15), 7535-42. https://doi.org/10.1128/JVI.02684-09

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Krenn, B. M., Gaudernak, E., Holzer, B., Lanke, K., Van Kuppeveld, F. J. M., & Seipelt, J. (2009). Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. Journal of Virology, 83(1), 58-64. https://doi.org/10.1128/JVI.01543-08

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Duijsings, D., Lanke, K. H. W., van Dooren, S. H. J., van Dommelen, M. M. T., Wetzels, R., de Mattia, F., Wessels, E., & van Kuppeveld, F. J. M. (2009). Differential membrane association properties and regulation of class I and class II Arfs. Traffic, 10(3), 316-23. https://doi.org/10.1111/j.1600-0854.2008.00868.x

Zoll, J., Galama, J. M. D., & van Kuppeveld, F. J. M. (2009). Identification of potential recombination breakpoints in human parechoviruses. Journal of Virology, 83(7), 3379-83. https://doi.org/10.1128/JVI.02529-08

De Palma, A. M., Thibaut, H. J., van der Linden, L., Lanke, K., Heggermont, W., Ireland, S., Andrews, R., Arimilli, M., Al-Tel, T. H., De Clercq, E., van Kuppeveld, F., & Neyts, J. (2009). Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrobial Agents and Chemotherapy, 53(5), 1850-7. https://doi.org/10.1128/AAC.00934-08

Zoll, J., Erkens Hulshof, S., Lanke, K., Verduyn Lunel, F., Melchers, W. J. G., Schoondermark-van de Ven, E., Roivainen, M., Galama, J. M. D., & van Kuppeveld, F. J. M. (2009). Saffold virus, a human Theiler's-like cardiovirus, is ubiquitous and causes infection early in life. PLoS Pathogens, 5(5), e1000416. https://doi.org/10.1371/journal.ppat.1000416

Romanova, L. I., Lidsky, P. V., Kolesnikova, M. S., Fominykh, K. V., Gmyl, A. P., Sheval, E. V., Hato, S. V., van Kuppeveld, F. J. M., & Agol, V. I. (2009). Antiapoptotic activity of the cardiovirus leader protein, a viral "security" protein. Journal of Virology, 83(14), 7273-84. https://doi.org/10.1128/JVI.00467-09

de Mattia, F., Gubser, C., van Dommelen, M. M. T., Visch, H.-J., Distelmaier, F., Postigo, A., Luyten, T., Parys, J. B., de Smedt, H., Smith, G. L., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2009). Human Golgi antiapoptotic protein modulates intracellular calcium fluxes. Molecular Biology of the Cell, 20(16), 3638-45. https://doi.org/10.1091/mbc.E09-05-0385

Lidsky, P. V., Romanova, L. I., Kolesnikova, M. S., Bardina, M. V., Khitrina, E. V., Hato, S. V., van Kuppeveld, F. J. M., & Agol, V. I. (2009). Interactions between viral and prokaryotic pathogens in a mixed infection with cardiovirus and mycoplasma. Journal of Virology, 83(19), 9940-51. https://doi.org/10.1128/JVI.01167-09

Ricour, C., Borghese, F., Sorgeloos, F., Hato, S. V., van Kuppeveld, F. J. M., & Michiels, T. (2009). Random mutagenesis defines a domain of Theiler's virus leader protein that is essential for antagonism of nucleocytoplasmic trafficking and cytokine gene expression. Journal of Virology, 83(21), 11223-32. https://doi.org/10.1128/JVI.00829-09

Lanke, K. H. W., van der Schaar, H. M., Belov, G. A., Feng, Q., Duijsings, D., Jackson, C. L., Ehrenfeld, E., & van Kuppeveld, F. J. M. (2009). GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication. Journal of Virology, 83(22), 11940-9. https://doi.org/10.1128/JVI.01244-09

Kramer, M., Schulte, B. M., Toonen, L. W. J., Barral, P. M., Fisher, P. B., Lanke, K. H. W., Galama, J. M. D., van Kuppeveld, F. J. M., & Adema, G. J. (2008). Phagocytosis of picornavirus-infected cells induces an RNA-dependent antiviral state in human dendritic cells. Journal of Virology, 82(6), 2930-7. https://doi.org/10.1128/JVI.02376-07

de Jong, A. S., de Mattia, F., Van Dommelen, M. M., Lanke, K., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2008). Functional analysis of picornavirus 2B proteins: effects on calcium homeostasis and intracellular protein trafficking. Journal of Virology, 82(7), 3782-90. https://doi.org/10.1128/JVI.02076-07

de Vries, W., Haasnoot, J., van der Velden, J., van Montfort, T., Zorgdrager, F., Paxton, W., Cornelissen, M., van Kuppeveld, F., de Haan, P., & Berkhout, B. (2008). Increased virus replication in mammalian cells by blocking intracellular innate defense responses. Gene Therapy, 15(7), 545-52. https://doi.org/10.1038/gt.2008.12

De Palma, A. M., Heggermont, W., Lanke, K., Coutard, B., Bergmann, M., Monforte, A.-M., Canard, B., De Clercq, E., Chimirri, A., Pürstinger, G., Rohayem, J., van Kuppeveld, F., & Neyts, J. (2008). The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C. Journal of Virology, 82(10), 4720-30. https://doi.org/10.1128/JVI.01338-07

Verheije, M. H., Raaben, M., Mari, M., Te Lintelo, E. G., Reggiori, F., van Kuppeveld, F. J. M., Rottier, P. J. M., & de Haan, C. A. M. (2008). Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. PLoS Pathogens, 4(6), Article e1000088. https://doi.org/10.1371/journal.ppat.1000088

Kramer, M., Schulte, B. M., Toonen, L. W. J., de Bruijni, M. A. M., Galama, J. M. D., Adema, G. J., & van Kuppeveld, F. J. M. (2007). Echovirus infection causes rapid loss-of-function and cell death in human dendritic cells. Cellular Microbiology, 9(6), 1507-18. https://doi.org/10.1111/j.1462-5822.2007.00888.x

Gubser, C., Bergamaschi, D., Hollinshead, M., Lu, X., van Kuppeveld, F. J. M., & Smith, G. L. (2007). A new inhibitor of apoptosis from vaccinia virus and eukaryotes. PLoS Pathogens, 3(2), e17. https://doi.org/10.1371/journal.ppat.0030017

Wessels, E., Duijsings, D., Lanke, K. H. W., Melchers, W. J. G., Jackson, C. L., & van Kuppeveld, F. J. M. (2007). Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1. Journal of Virology, 81(10), 5238-45. https://doi.org/10.1128/JVI.02680-06

Lanke, K., Krenn, B. M., Melchers, W. J. G., Seipelt, J., & van Kuppeveld, F. J. M. (2007). PDTC inhibits picornavirus polyprotein processing and RNA replication by transporting zinc ions into cells. Journal of General Virology, 88(Pt 4), 1206-17. https://doi.org/10.1099/vir.0.82634-0

Zoll, J., Tessari, M., Van Kuppeveld, F. J. M., Melchers, W. J. G., & Heus, H. A. (2007). Breaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairs. RNA, 13(5), 781-92. https://doi.org/10.1261/rna.375607

Duijsings, D., Wessels, E., van Emst-de Vries, S. E., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2007). Reduction of phospholipase D activity during coxsackievirus infection. Journal of General Virology, 88(Pt 11), 3027-30. https://doi.org/10.1099/vir.0.83169-0

Hato, S. V., Ricour, C., Schulte, B. M., Lanke, K. H. W., de Bruijni, M., Zoll, J., Melchers, W. J. G., Michiels, T., & van Kuppeveld, F. J. M. (2007). The mengovirus leader protein blocks interferon-alpha/beta gene transcription and inhibits activation of interferon regulatory factor 3. Cellular Microbiology, 9(12), 2921-30. https://doi.org/10.1111/j.1462-5822.2007.01006.x

van Ooij, M. J. M., Vogt, D. A., Paul, A., Castro, C., Kuijpers, J., van Kuppeveld, F. J. M., Cameron, C. E., Wimmer, E., Andino, R., & Melchers, W. J. G. (2006). Structural and functional characterization of the coxsackievirus B3 CRE(2C): role of CRE(2C) in negative- and positive-strand RNA synthesis. Journal of General Virology, 87(Pt 1), 103-13. https://doi.org/10.1099/vir.0.81297-0

van Ooij, M. J. M., Glaudemans, D. H. R. F., Heus, H. A., van Kuppeveld, F. J. M., & Melchers, W. J. G. (2006). Structural and functional integrity of the coxsackievirus B3 oriR: spacing between coaxial RNA helices. Journal of General Virology, 87(Pt 3), 689-95. https://doi.org/10.1099/vir.0.81558-0

Lidsky, P. V., Hato, S., Bardina, M. V., Aminev, A. G., Palmenberg, A. C., Sheval, E. V., Polyakov, V. Y., van Kuppeveld, F. J. M., & Agol, V. I. (2006). Nucleocytoplasmic traffic disorder induced by cardioviruses. Journal of Virology, 80(6), 2705-17. https://doi.org/10.1128/JVI.80.6.2705-2717.2006

de Jong, A. S., Visch, H.-J., de Mattia, F., van Dommelen, M. M., Swarts, H. G., Luyten, T., Callewaert, G., Melchers, W. J., Willems, P. H., & van Kuppeveld, F. J. (2006). The coxsackievirus 2B protein increases efflux of ions from the endoplasmic reticulum and Golgi, thereby inhibiting protein trafficking through the Golgi. Journal of Biological Chemistry, 281(20), 14144-50. https://doi.org/10.1074/jbc.M511766200

Visch, H.-J., Koopman, W. J. H., Zeegers, D., van Emst-de Vries, S. E., van Kuppeveld, F. J. M., van den Heuvel, L. W. P. J., Smeitink, J. A. M., & Willems, P. H. G. M. (2006). Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency. American Journal of Physiology-Cell Physiology, 291(2), C308-16. https://doi.org/10.1152/ajpcell.00561.2005

van Ooij, M. J. M., Polacek, C., Glaudemans, D. H. R. F., Kuijpers, J., van Kuppeveld, F. J. M., Andino, R., Agol, V. I., & Melchers, W. J. G. (2006). Polyadenylation of genomic RNA and initiation of antigenomic RNA in a positive-strand RNA virus are controlled by the same cis-element. Nucleic Acids Research, 34(10), 2953-65. https://doi.org/10.1093/nar/gkl349

Wessels, E., Notebaart, R. A., Duijsings, D., Lanke, K., Vergeer, B., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). Structure-function analysis of the coxsackievirus protein 3A: identification of residues important for dimerization, viral rna replication, and transport inhibition. Journal of Biological Chemistry, 281(38), 28232-43. https://doi.org/10.1074/jbc.M601122200

Wessels, E., Duijsings, D., Lanke, K. H. W., van Dooren, S. H. J., Jackson, C. L., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). Effects of picornavirus 3A Proteins on Protein Transport and GBF1-dependent COP-I recruitment. Journal of Virology, 80(23), 11852-60. https://doi.org/10.1128/JVI.01225-06

Wessels, E., Duijsings, D., Niu, T.-K., Neumann, S., Oorschot, V. M., de Lange, F., Lanke, K. H. W., Klumperman, J., Henke, A., Jackson, C. L., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2006). A viral protein that blocks Arf1-mediated COP-I assembly by inhibiting the guanine nucleotide exchange factor GBF1. Developmental Cell, 11(2), 191-201. https://doi.org/10.1016/j.devcel.2006.06.005

van Kuppeveld, F. J. M., de Jong, A. S., Melchers, W. J. G., & Willems, P. H. G. M. (2005). Enterovirus protein 2B po(u)res out the calcium: a viral strategy to survive? Trends in Microbiology, 13(2), 41-4. https://doi.org/10.1016/j.tim.2004.12.005

Saelens, X., Festjens, N., Parthoens, E., Vanoverberghe, I., Kalai, M., van Kuppeveld, F., & Vandenabeele, P. (2005). Protein synthesis persists during necrotic cell death. Journal of Cell Biology, 168(4), 545-51. https://doi.org/10.1083/jcb.200407162

Wessels, E., Duijsings, D., Notebaart, R. A., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2005). A proline-rich region in the coxsackievirus 3A protein is required for the protein to inhibit endoplasmic reticulum-to-golgi transport. Journal of Virology, 79(8), 5163-73. https://doi.org/10.1128/JVI.79.8.5163-5173.2005

Krenn, B. M., Holzer, B., Gaudernak, E., Triendl, A., van Kuppeveld, F. J., & Seipelt, J. (2005). Inhibition of polyprotein processing and RNA replication of human rhinovirus by pyrrolidine dithiocarbamate involves metal ions. Journal of Virology, 79(22), 13892-9. https://doi.org/10.1128/JVI.79.22.13892-13899.2005

Bopegamage, S., Kovacova, J., Vargova, A., Motusova, J., Petrovicova, A., Benkovicova, M., Gomolcak, P., Bakkers, J., van Kuppeveld, F., Melchers, W. J. G., & Galama, J. M. (2005). Coxsackie B virus infection of mice: inoculation by the oral route protects the pancreas from damage, but not from infection. Journal of General Virology, 86(Pt 12), 3271-80. https://doi.org/10.1099/vir.0.81249-0

Campanella, M., de Jong, A. S., Lanke, K. W. H., Melchers, W. J. G., Willems, P. H. G. M., Pinton, P., Rizzuto, R., & van Kuppeveld, F. J. M. (2004). The coxsackievirus 2B protein suppresses apoptotic host cell responses by manipulating intracellular Ca2+ homeostasis. Journal of Biological Chemistry, 279(18), 18440-50. https://doi.org/10.1074/jbc.M309494200

de Jong, A. S., Melchers, W. J. G., Glaudemans, D. H. R. F., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2004). Mutational analysis of different regions in the coxsackievirus 2B protein: requirements for homo-multimerization, membrane permeabilization, subcellular localization, and virus replication. Journal of Biological Chemistry, 279(19), 19924-35. https://doi.org/10.1074/jbc.M314094200

de Jong, A. S., Wessels, E., Dijkman, H. B. P. M., Galama, J. M. D., Melchers, W. J. G., Willems, P. H. G. M., & van Kuppeveld, F. J. M. (2003). Determinants for membrane association and permeabilization of the coxsackievirus 2B protein and the identification of the Golgi complex as the target organelle. Journal of Biological Chemistry, 278(2), 1012-21. https://doi.org/10.1074/jbc.M207745200

Lescrinier, E. M. H. P., Tessari, M., van Kuppeveld, F. J. M., Melchers, W. J. G., Hilbers, C. W., & Heus, H. A. (2003). Structure of the pyrimidine-rich internal loop in the poliovirus 3'-UTR: the importance of maintaining pseudo-2-fold symmetry in RNA helices containing two adjacent non-canonical base-pairs. Journal of Molecular Biology, 331(4), 759-69.

Merkle, I., van Ooij, M. J. M., van Kuppeveld, F. J. M., Glaudemans, D. H. R. F., Galama, J. M. D., Henke, A., Zell, R., & Melchers, W. J. G. (2002). Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region. Journal of Virology, 76(19), 9900-9.

van Kuppeveld, F. J. M., de Jong, A., Dijkman, H. B. P. M., Andino, R., & Melchers, W. J. G. (2002). Studies towards the potential of poliovirus as a vector for the expression of HPV 16 virus-like-particles. FEMS Immunology and Medical Microbiology, 34(3), 201-8.

Zoll, J., Melchers, W. J. G., Galama, J. M. D., & van Kuppeveld, F. J. M. (2002). The mengovirus leader protein suppresses alpha/beta interferon production by inhibition of the iron/ferritin-mediated activation of NF-kappa B. Journal of Virology, 76(19), 9664-72.

van Kuppeveld, F. J. M., Melchers, W. J. G., Willems, P. H. G. M., & Gadella, T. W. J. (2002). Homomultimerization of the coxsackievirus 2B protein in living cells visualized by fluorescence resonance energy transfer microscopy. Journal of Virology, 76(18), 9446-56.

de Jong, A. S., Schrama, I. W. J., Willems, P. H. G. M., Galama, J. M. D., Melchers, W. J. G., & van Kuppeveld, F. J. M. (2002). Multimerization reactions of coxsackievirus proteins 2B, 2C and 2BC: a mammalian two-hybrid analysis. Journal of General Virology, 83(Pt 4), 783-93.

van Kuppeveld, F. J. M., van den Hurk, P. J. J. C., Schrama, I. W. J., Galama, J. M. D., & Melchers, W. J. G. (2002). Trans-complementation of a genetic defect in the coxsackie B3 virus 2B protein. Journal of General Virology, 83(Pt 2), 341-50.

Zoll, J., van Kuppeveld, F. J., Galama, J. M., & Melchers, W. J. (1998). Genetic analysis of mengovirus protein 2A: its function in polyprotein processing and virus reproduction. Journal of General Virology, 79 ( Pt 1), 17-25.

Van Horssen, A. M., Van Kuppeveld, F. J., & Martens, G. J. (1998). Manipulation of disulfide bonds differentially affects the intracellular transport, sorting, and processing of neuroendocrine secretory proteins. Journal of Neurochemistry, 71(1), 402-9.

Van kuppeveld, F. J., Melchers, W. J., Kirkegaard, K., & Doedens, J. R. (1997). Structure-function analysis of coxsackie B3 virus protein 2B. Virology, 227(1), 111-8. https://doi.org/10.1006/viro.1996.8320

van Kuppeveld, F. J., Hoenderop, J. G., Smeets, R. L., Willems, P. H., Dijkman, H. B., Galama, J. M., & Melchers, W. J. (1997). Coxsackievirus protein 2B modifies endoplasmic reticulum membrane and plasma membrane permeability and facilitates virus release. EMBO Journal, 16(12), 3519-32. https://doi.org/10.1093/emboj/16.12.3519

van Kuppeveld, F. J., van den Hurk, P. J., van der Vliet, W., Galama, J. M., & Melchers, W. J. (1997). Chimeric coxsackie B3 virus genomes that express hybrid coxsackievirus-poliovirus 2B proteins: functional dissection of structural domains involved in RNA replication. Journal of General Virology, 78 ( Pt 8), 1833-40.

van Kuppeveld, F. J., van Horssen, A. M., & Martens, G. J. (1997). Intracellular transport, sorting, and proteolytic processing of regulated secretory proteins does not require protein sulfation. Molecular and Cellular Endocrinology, 136(1), 29-35.

van Kuppeveld, F., van der Logt, J., Johansson, K. E., & Melchers, W. (1996). Demonstration of Mycoplasma contamination in cell cultures by a Mycoplasma group- specific polymerase chain reaction. Methods, 2, 525-38. https://doi.org/10.1385/0-89603-335-X:525

van Kuppeveld, F. J., Galama, J. M., Zoll, J., van den Hurk, P. J., & Melchers, W. J. (1996). Coxsackie B3 virus protein 2B contains cationic amphipathic helix that is required for viral RNA replication. Journal of Virology, 70(6), 3876-86.

Zoll, J., Galama, J. M., van Kuppeveld, F. J., & Melchers, W. J. (1996). Mengovirus leader is involved in the inhibition of host cell protein synthesis. Journal of Virology, 70(8), 4948-52.

van Kuppeveld, F. J., van den Hurk, P. J., Zoll, J., Galama, J. M., & Melchers, W. J. (1996). Mutagenesis of the coxsackie B3 virus 2B/2C cleavage site: determinants of processing efficiency and effects on viral replication. Journal of Virology, 70(11), 7632-40.

van Kuppeveld, F. J., Galama, J. M., Zoll, J., & Melchers, W. J. (1995). Genetic analysis of a hydrophobic domain of coxsackie B3 virus protein 2B: a moderate degree of hydrophobicity is required for a cis-acting function in viral RNA synthesis. Journal of Virology, 69(12), 7782-90.

Tjhie, J. H., van Kuppeveld, F. J., Roosendaal, R., Melchers, W. J., Gordijn, R., MacLaren, D. M., Walboomers, J. M., Meijer, C. J., & van den Brule, A. J. (1994). Direct PCR enables detection of Mycoplasma pneumoniae in patients with respiratory tract infections. Journal of Clinical Microbiology, 32(1), 11-6.

van Kuppeveld, F. J., Johansson, K. E., Galama, J. M., Kissing, J., Bölske, G., van der Logt, J. T., & Melchers, W. J. (1994). Detection of mycoplasma contamination in cell cultures by a mycoplasma group-specific PCR. Applied and Environmental Microbiology, 60(1), 149-52.

van Kuppeveld, F., Melchers, W., Kissing, J., van der Logt, J., & Galama, J. (1994). No evidence of mycoplasmas in peripheral blood mononuclear cell fraction of HIV-infected patients. Infection, 22(3), 204-6.

van Kuppeveld, F. J., Johansson, K. E., Galama, J. M., Kissing, J., Bölske, G., Hjelm, E., van der Logt, J. T., & Melchers, W. J. (1994). 16S rRNA based polymerase chain reaction compared with culture and serological methods for diagnosis of Mycoplasma pneumoniae infection. European Journal of Clinical Microbiology & Infectious Diseases, 13(5), 401-5.

Zoll, J., Jongen, P., Galama, J., van Kuppeveld, F., & Melchers, W. (1993). Coxsackievirus B1-induced murine myositis: no evidence for viral persistence. Journal of General Virology, 74 ( Pt 10), 2071-6.

van Kuppeveld, F. J., Melchers, W. J., Willemse, H. F., Kissing, J., Galama, J. M., & van der Logt, J. T. (1993). Detection of Mycoplasma pulmonis in experimentally infected laboratory rats by 16S rRNA amplification. Journal of Clinical Microbiology, 31(3), 524-7.

van Kuppeveld, F. J., van der Logt, J. T., Angulo, A. F., van Zoest, M. J., Quint, W. G., Niesters, H. G., Galama, J. M., & Melchers, W. J. (1993). Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification. Applied and Environmental Microbiology, 59(2), 655.

van Kuppeveld, F. J., van der Logt, J. T., Angulo, A. F., van Zoest, M. J., Quint, W. G., Niesters, H. G., Galama, J. M., & Melchers, W. J. (1992). Genus- and species-specific identification of mycoplasmas by 16S rRNA amplification. Applied and Environmental Microbiology, 58(8), 2606-15.

Meis, J. F., van Kuppeveld, F. J., Kremer, J. A., Nijhuis, J. G., & Melchers, W. J. (1992). Fatal intrauterine infection associated with Mycoplasma hominis. Clinical Infectious Diseases, 15(4), 753-4.