Du W#, Dai M#, Li Z, Boons GJ, Peeters B, van Kuppeveld FJM, de Vries E, de Haan CAM. (2018) Substrate Binding by the Second Sialic Acid-Binding Site of Influenza A Virus N1 Neuraminidase Contributes to Enzymatic Activity. Journal of virology 92(20):e01243-01218
Du W, Guo H, Nijman VS, Doedt J, van der Vries E, van der Lee J, Li Z, Boons GJ, van Kuppeveld FJM, de Vries E, Matrosovich M, de Haan CAM. (2019) The 2nd sialic acid-binding site of influenza A virus neuraminidase is an important determinant of the hemagglutinin-neuraminidase-receptor balance. PLOS Pathogens 15(6):e1007860.
Publications
2022
Scholarly publications
Rothenberger, S., Hurdiss, D. L., Walser, M., Malvezzi, F., Mayor, J., Ryter, S., Moreno, H., Liechti, N., Bosshart, A., Iss, C., Calabro, V., Cornelius, A., Hospodarsch, T., Neculcea, A., Looser, T., Schlegel, A., Fontaine, S., Villemagne, D., Paladino, M., ... Trimpert, J. (2022). The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants. Nature Biotechnology. https://doi.org/10.1038/s41587-022-01382-3
Wei, X., Du, W., Duca, M., Yu, G., de Vries, E., de Haan, C. A. M., & Pieters, R. J. (2022). Preventing Influenza A Virus Infection by Mixed Inhibition of Neuraminidase and Hemagglutinin by Divalent Inhibitors. Journal of Medicinal Chemistry, 65(10), 7312-7323. https://doi.org/10.1021/acs.jmedchem.2c00319
Du, W., Hurdiss, D. L., Drabek, D., Mykytyn, A. Z., Kaiser, F. K., González-Hernández, M., Muñoz-Santos, D., Lamers, M. M., van Haperen, R., Li, W., Drulyte, I., Wang, C., Sola, I., Armando, F., Beythien, G., Ciurkiewicz, M., Baumgärtner, W., Guilfoyle, K., Smits, T., ... Bosch, B-J. (2022). An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern. Science immunology, 7(73), 1-15. [eabp9312]. https://doi.org/10.1126/sciimmunol.abp9312
Evers, M. J. W., Du, W., Yang, Q., Kooijmans, S. A. A., Vink, A., van Steenbergen, M., Vader, P., de Jager, S. C. A., Fuchs, S. A., Mastrobattista, E., Sluijter, J. P. G., Lei, Z., & Schiffelers, R. (2022). Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles. Journal of Controlled Release, 343, 207-216. https://doi.org/10.1016/j.jconrel.2022.01.027
Rodriguez-Conde, S., Inman, S., Lindo, V., Amery, L., Tang, A., Okorji-Obike, U., Du, W., Bosch, B-J., Wichgers Schreur, P. J., Kortekaas, J., Sola, I., Enjuanes, L., Kerry, L., Mahal, K., Hulley, M., & Daramola, O. (2022). Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales. mAbs, 14(1), 1-12. [2052228]. https://doi.org/10.1080/19420862.2022.2052228
2021
Scholarly publications
Fenwick, C., Turelli, P., Perez, L., Pellaton, C., Esteves-Leuenberger, L., Farina, A., Campos, J., Lana, E., Fiscalini, F., Raclot, C., Pojer, F., Lau, K., Demurtas, D., Descatoire, M., Joo, V. S., Foglierini, M., Noto, A., Abdelnabi, R., Foo, C. S., ... Pantaleo, G. (2021). A highly potent antibody effective against SARS-CoV-2 variants of concern. Cell Reports, 37(2), [109814]. https://doi.org/10.1016/j.celrep.2021.109814
Nason, R., Büll, C., Konstantinidi, A., Sun, L., Ye, Z., Halim, A., Du, W., Sørensen, D. M., Durbesson, F., Furukawa, S., Mandel, U., Joshi, H. J., Dworkin, L. A., Hansen, L., David, L., Iverson, T. M., Bensing, B. A., Sullam, P. M., Varki, A., ... Narimatsu, Y. (2021). Display of the human mucinome with defined O-glycans by gene engineered cells. Nature Communications, 12(1), 1-16. [4070]. https://doi.org/10.1038/s41467-021-24366-4
Dai, M., Du, W., Martínez-Romero, C., Leenders, T., Wennekes, T., Rimmelzwaan, G. F., van Kuppeveld, F. J. M., Fouchier, R. A. M., Garcia-Sastre, A., de Vries, E., & de Haan, C. A. M. (2021). Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics. mBio, 12(3), 1-18. [e00287-21]. https://doi.org/10.1128/mBio.00287-21
Fedry, J., Hurdiss, D. L., Wang, C., Li, W., Obal, G., Drulyte, I., Du, W., Howes, S. C., van Kuppeveld, F. J. M., Förster, F., & Bosch, B-J. (2021). Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Science advances, 7(23), 1-11. [eabf5632]. https://doi.org/10.1126/sciadv.abf5632
2020
Scholarly publications
Du, W. (2020). Functional crosstalk between influenza A virus hemagglutinin and neuraminidase. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University. https://doi.org/10.33540/57
Du, W., de Vries, E., van Kuppeveld, F. J. M., Matrosovich, M., & de Haan, C. A. M. (2020). Second sialic acid-binding site of influenza A virus neuraminidase: Binding receptors for efficient release. The FEBS journal. https://doi.org/10.1111/febs.15668
Du, W., Wolfert, M. A., Peeters, B., van Kuppeveld, F. J. M., Boons, G-J., de Vries, E., & de Haan, C. A. M. (2020). Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin. PLoS Pathogens, 16(8), 1-20. [e1008816]. https://doi.org/10.1371/journal.ppat.1008816