Dr. S.C. (Stuart) Howes

David de Wiedgebouw
Universiteitsweg 99
Kamer 2.66
3584 CG Utrecht

Dr. S.C. (Stuart) Howes

Assistant Professor
Structural Biochemistry
+31 30 253 3005



Shazeeb, M. S., Howes, S., Kandasamy, S., Peiris, T. B., Sotak, C. H., & Pins, G. D. (2019). Developing quantitative MRI parameters to characterize host response and tissue ingrowth into collagen scaffolds. NMR in Biomedicine, 32(3), e4059. https://doi.org/10.1002/nbm.4059


Ugurlar, D., Howes, S. C., de Kreuk, B-J., Koning, R. I., de Jong, R. N., Beurskens, F. J., Schuurman, J., Koster, A. J., Sharp, T. H., Parren, P. W. H. I., & Gros, P. (2018). Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science, 359(6377), 794-797. https://doi.org/10.1126/science.aao4988
Howes, S. C., Geyer, E. A., LaFrance, B., Zhang, R., Kellogg, E. H., Westermann, S., Rice, L. M., & Nogales, E. (2018). Structural and functional differences between porcine brain and budding yeast microtubules. Cell Cycle, 17(3), 278-287. https://doi.org/10.1080/15384101.2017.1415680
Howes, S. C., Koning, R. I., & Koster, A. J. (2018). Correlative microscopy for structural microbiology. Current Opinion in Microbiology, 43, 132-138. https://doi.org/10.1016/j.mib.2018.01.009


Kellogg, E. H., Hejab, N. M. A., Howes, S., Northcote, P., Miller, J. H., Díaz, J. F., Downing, K. H., & Nogales, E. (2017). Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures. Journal of Molecular Biology, 429(5), 633-646. https://doi.org/10.1016/j.jmb.2017.01.001
Howes, S. C., Geyer, E. A., LaFrance, B., Zhang, R., Kellogg, E. H., Westermann, S., Rice, L. M., & Nogales, E. (2017). Structural differences between yeast and mammalian microtubules revealed by cryo-EM. Journal of Cell Biology, 216(9), 2669-2677. https://doi.org/10.1083/jcb.201612195


Ti, S-C., Pamula, M. C., Howes, S. C., Duellberg, C., Cade, N. I., Kleiner, R. E., Forth, S., Surrey, T., Nogales, E., & Kapoor, T. M. (2016). Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends. Developmental Cell, 37(1), 72-84. https://doi.org/10.1016/j.devcel.2016.03.003
Kellogg, E. H., Howes, S., Ti, S-C., Ramírez-Aportela, E., Kapoor, T. M., Chacón, P., & Nogales, E. (2016). Near-atomic cryo-EM structure of PRC1 bound to the microtubule. Proceedings of the National Academy of Sciences of the United States of America, 113(34), 9430-9. https://doi.org/10.1073/pnas.1609903113


Nakamura, M., Chen, L., Howes, S. C., Schindler, T. D., Nogales, E., & Bryant, Z. (2014). Remote control of myosin and kinesin motors using light-activated gearshifting. Nature Nanotechnology, 9(9), 693-7. https://doi.org/10.1038/nnano.2014.147
Howes, S. C., Alushin, G. M., Shida, T., Nachury, M. V., & Nogales, E. (2014). Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure. Molecular Biology of the Cell, 25(2), 257-66. https://doi.org/10.1091/mbc.E13-07-0387


Musinipally, V., Howes, S., Alushin, G. M., & Nogales, E. (2013). The microtubule binding properties of CENP-E's C-terminus and CENP-F. Journal of Molecular Biology, 425(22), 4427-41. https://doi.org/10.1016/j.jmb.2013.07.027


Rissin, D. M., Fournier, D. R., Piech, T., Kan, C. W., Campbell, T. G., Song, L., Chang, L., Rivnak, A. J., Patel, P. P., Provuncher, G. K., Ferrell, E. P., Howes, S. C., Pink, B. A., Minnehan, K. A., Wilson, D. H., & Duffy, D. C. (2011). Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range. Analytical Chemistry, 83(6), 2279-85. https://doi.org/10.1021/ac103161b
Ramey, V. H., Wong, A., Fang, J., Howes, S., Barnes, G., & Nogales, E. (2011). Subunit organization in the Dam1 kinetochore complex and its ring around microtubules. Molecular Biology of the Cell, 22(22), 4335-42. https://doi.org/10.1091/mbc.E11-07-0659


Rissin, D. M., Kan, C. W., Campbell, T. G., Howes, S. C., Fournier, D. R., Song, L., Piech, T., Patel, P. P., Chang, L., Rivnak, A. J., Ferrell, E. P., Randall, J. D., Provuncher, G. K., Walt, D. R., & Duffy, D. C. (2010). Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nature Biotechnology, 28(6), 595-9. https://doi.org/10.1038/nbt.1641