Publications
2022
Scholarly publications
van der Grein, S. G., Defourny, K. A. Y., Rabouw, H. H., Goerdayal, S. S., van Herwijnen, M. J. C., Wubbolts, R. W., Altelaar, M., van Kuppeveld, F. J. M., & Nolte-'t Hoen, E. N. M. (2022). The encephalomyocarditis virus Leader promotes the release of virions inside extracellular vesicles via the induction of secretory autophagy. Nature Communications, 13(1), 1-14. [3625]. https://doi.org/10.1038/s41467-022-31181-y
2021
Scholarly publications
Chatterjee, M., Huang, L. Z. X., Wang, C., Mykytyn, A. Z., Westendorp, B., Wubbolts, R. W., Bosch, B-J., Haagmans, B. L., Putten, J. P. M. V., & Strijbis, K. (2021). The glycosylated extracellular domain of MUC1 protects against SARS-CoV-2 infection at the respiratory surface. bioRxiv. https://doi.org/10.1101/2021.10.29.466408
Verweij, F. J., Balaj, L., Boulanger, C. M., Carter, D. R. F., Compeer, E. B., D'Angelo, G., El Andaloussi, S., Goetz, J. G., Gross, J. C., Hyenne, V., Krämer-Albers, E-M., Lai, C. P., Loyer, X., Marki, A., Momma, S., Nolte-'t Hoen, E. N. M., Pegtel, D. M., Peinado, H., Raposo, G., ... van Niel, G. (2021). The power of imaging to understand extracellular vesicle biology in vivo. Nature Methods, 18(9), 1013-1026. https://doi.org/10.1038/s41592-021-01206-3
Molenaar, M. R., Yadav, K. K., Toulmay, A., Wassenaar, T. A., Mari, M. C., Caillon, L., Chorlay, A., Lukmantara, I. E., Haaker, M. W., Wubbolts, R. W., Houweling, M., Vaandrager, A. B., Prieur, X., Reggiori, F., Choudhary, V., Yang, H., Schneiter, R., Thiam, A. R., Prinz, W. A., & Helms, J. B. (2021). Retinyl esters form lipid droplets independently of triacylglycerol and seipin. Journal of Cell Biology, 220(10), 1-14. [e202011071]. https://doi.org/10.1083/jcb.202011071
Li, X., Wubbolts, R. W., Bleumink-Pluym, N. M. C., van Putten, J. P. M., & Strijbis, K. (2021). The transmembrane mucin muc1 facilitates b1-integrin-mediated bacterial invasion. mBio, 12(2), 1-16. [e03491-20]. https://doi.org/10.1128/mBio.03491-20
Nemanichvili, N., Berends, A. J., Wubbolts, R. W., Gröne, A., Rijks, J. M., de Vries, R. P., & Verheije, M. H. (2021). Tissue Microarrays to Visualize Influenza D Attachment to Host Receptors in the Respiratory Tract of Farm Animals. Viruses, 13(4), 1-13. [586]. https://doi.org/10.3390/v13040586
2020
Scholarly publications
Segeren, H. A., van Rijnberk, L. M., Moreno, E., Riemers, F. M., van Liere, E. A., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage. Cell Reports, 33(9), [108449]. https://doi.org/10.1016/j.celrep.2020.108449
Lindenbergh, M. F. S., Wubbolts, R., Borg, E. G. F., van ’T Veld, E. M., Boes, M., & Stoorvogel, W. (2020). Dendritic cells release exosomes together with phagocytosed pathogen; potential implications for the role of exosomes in antigen presentation. Journal of Extracellular Vesicles, 9(1), [1798606 ]. https://doi.org/10.1080/20013078.2020.1798606
Segeren, H. A., van Rijnberk, L., Moreno, E., Riemers, F., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell Cycle Exit after DNA Damage. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3570558
2019
Scholarly publications
Heesterbeek, D. A. C., Martin, N. I., Velthuizen, A., Duijst, M., Ruyken, M., Wubbolts, R., Rooijakkers, S. H. M., & Bardoel, B. W. (2019). Publisher Correction: Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics (Scientific Reports, (2018), 8, 1, (15409), 10.1038/s41598-018-33850-9). Scientific Reports, 9(1), [7841]. https://doi.org/10.1038/s41598-019-43208-4
Tukker, A. M., Wijnolts, F. M. J., de Groot, A., Wubbolts, R. W., & Westerink, R. H. S. (2019). In vitro techniques for assessing neurotoxicity using human IPSC-derived neuronal models. In M. Aschner, & L. Costa (Eds.), Cell Culture Techniques (pp. 17-35). (Neuromethods; Vol. 145). Humana Press. https://doi.org/10.1007/978-1-4939-9228-7_2
Heesterbeek, D. A. C., Martin, N. I., Velthuizen, A., Duijst, M., Ruyken, M., Wubbolts, R., Rooijakkers, S. H. M., & Bardoel, B. W. (2019). Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics. Scientific Reports, 9(1), [3074]. https://doi.org/10.1038/s41598-019-38577-9
Lindenbergh, M. F. S., Koerhuis, D. G. J., Borg, E. G. F., van ‘t Veld, E. M., Driedonks, T. A. P., Wubbolts, R., Stoorvogel, W., & Boes, M. (2019). Bystander T-Cells Support Clonal T-Cell Activation by Controlling the Release of Dendritic Cell-Derived Immune-Stimulatory Extracellular Vesicles. Frontiers in Immunology, 10, [448]. https://doi.org/10.3389/fimmu.2019.00448
Li, X., Bleumink-Pluym, N. M. C., Luijkx, Y. M. C. A., Wubbolts, R. W., van Putten, J. P. M., & Strijbis, K. (2019). MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes. PLoS Pathogens, 15(2), [e1007566]. https://doi.org/10.1371/journal.ppat.1007566
2018
Scholarly publications
Chen, H., Wubbolts, R. W., Haagsman, H. P., & Veldhuizen, E. J. A. (2018). Inhibition and Eradication of Pseudomonas aeruginosa Biofilms by Host Defence Peptides. Scientific Reports, 8(1), [10446]. https://doi.org/10.1038/s41598-018-28842-8
2017
Scholarly publications
Tuohetahuntila, M., Molenaar, M. R., Spee, B., Brouwers, J. F., Wubbolts, R., Houweling, M., Yan, C., Du, H., VanderVen, B. C., Vaandrager, A. B., & Helms, J. B. (2017). Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation. Journal of Biological Chemistry, 292(30), 12436-12448. https://doi.org/10.1074/jbc.M117.778472
Aardema, H., van Tol, H. T. A., Wubbolts, R. W., Brouwers, J. F. H. M., Gadella, B. M., & Roelen, B. A. J. (2017). Stearoyl-CoA desaturase activity in bovine cumulus cells protects the oocyte against saturated fatty acid stress. Biology of Reproduction, 96(5), 982-992. https://doi.org/10.1095/biolreprod.116.146159
Brinkhof, B., van Tol, H. T. A., Groot Koerkamp, M. J. A., Wubbolts, R. W., Haagsman, H. P., & Roelen, B. A. J. (2017). Characterization of bovine embryos cultured under conditions appropriate for sustaining human naïve pluripotency. PLoS One, 12(2), [e0172920]. https://doi.org/10.1371/journal.pone.0172920
de Almeida Monteiro Melo Ferraz, M., Henning, H. H. W., Ferreira da Costa, P., Malda, J., Melchels, F. P. W., Wubbolts, R. W., Stout, T. A. E., Vos, P. L. A. M., & Gadella, B. M. (2017). Improved bovine embryo production in an oviduct-on-a-chip system: prevention of poly-spermic fertilization and parthenogenic activation. Lab on a Chip - Miniaturisation for Chemistry and Biology, 17(5), 905-916. https://doi.org/10.1039/c6lc01566b
Other output
Wollman, A. J. M., Haapasalo-Tuomainen, K., Haas, C., Aerts, P. C., Van'T Veld, E., Wubbolts, R., van Kessel, K., van Strijp, J. A. G., & Leake, M. C. (2017). Single-molecule microscopy of Staphylococcal pore-forming toxins on live mammalian cells. European Biophysics Journal, 46(S1), 381. https://doi.org/10.1007/s00249-017-1222-x
2016
Scholarly publications
Haapasalo-Tuomainen, K., Wollman, A., De Haas, C., Aerts, P., Van'T Veld, E., Strijbis, K., Wubbolts, R., Van Kessel, K., Leake, M., & Van Strijp, J. (2016). Characterization of the stoichiometry of the complex formed by Staphylococcal toxin LukSF and human C5a receptor. Immunobiology, 221(10), 1141. https://doi.org/10.1016/j.imbio.2016.06.039
de Goeij, B. E., Vink, T., Ten Napel, H., Breij, E. C., Satijn, D., Wubbolts, R., Miao, D., & Parren, P. W. (2016). Efficient payload delivery by a bispecific antibody-drug conjugate targeting HER2 and CD63. Molecular Cancer Therapeutics, 15(11), 2688-2697. https://doi.org/10.1158/1535-7163.MCT-16-0364
2015
Scholarly publications
Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports [E], 5(5), 895-907. https://doi.org/10.1016/j.stemcr.2015.09.002
de Goeij, B. E., Satijn, D., Freitag, C. M., Wubbolts, R., Bleeker, W. K., Khasanov, A., Zhu, T., Chen, G., Miao, D., van Berkel, P. H., & Parren, P. W. H. I. (2015). High turnover of Tissue Factor enables efficient intracellular delivery of antibody-drug conjugates. Molecular Cancer Therapeutics, 14, 1130-1140. https://doi.org/10.1158/1535-7163.MCT-14-0798
Albulescu, L., Wubbolts, R., van Kuppeveld, F. J. M., & Strating, J. R. P. M. (2015). Cholesterol shuttling is important for RNA replication of coxsackievirus B3 and encephalomyocarditis virus. Cellular Microbiology, 17(8), 1144-1156. https://doi.org/10.1111/cmi.12425
Strating, J. R. P. M., van der Linden, L., Albulescu, L., Bigay, J., Arita, M., Delang, L., Leyssen, P., van der Schaar, H. M., Lanke, K. H. W., Thibaut, H. J., Ulferts, R., Drin, G., Schlinck, N., Wubbolts, R. W., Sever, N., Head, S. A., Liu, J. O., Beachy, P. A., De Matteis, M. A., ... van Kuppeveld, F. J. M. (2015). Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein. Cell Reports [E], 10(4), 600-615. https://doi.org/10.1016/j.celrep.2014.12.054
Tuohetahuntila, M., Spee, B., Kruitwagen, H. S., Wubbolts, R., Brouwers, J. F., van de Lest, C. H., Molenaar, M. R., Houweling, M., Helms, J. B., & Vaandrager, A. B. (2015). Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells. Biochimica et Biophysica Acta, 1851(2), 220-30. https://doi.org/10.1016/j.bbalip.2014.12.003
Lolicato, F., Brouwers, J. F., van de Lest, C. H. A., Wubbolts, R., Aardema, H., Priore, P., Roelen, B. A. J., Helms, J. B., & Gadella, B. M. (2015). The Cumulus Cell Layer Protects Bovine Maturing Oocyte Against Fatty Acid-Induced Lipotoxicity. Biology of Reproduction, 92(1), [16]. https://doi.org/10.1095/biolreprod.114.120634
2014
Scholarly publications
Bach, F. C., Rutten, K., Hendriks, K., Riemers, F. M., Cornelissen, P., de Bruin, A., Arkesteijn, G. J., Wubbolts, R., Horton, W. A., Penning, L. C., & Tryfonidou, M. A. (2014). The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes. Journal of Cellular Physiology, 229(12), 1999-2014. https://doi.org/10.1002/jcp.24658
Ordonez Alvarez, S., Amarullah, I. H., Wubbolts, R. W., Veldhuizen, E. J. A., & Haagsman, H. P. (2014). Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging. Antimicrobial Agents and Chemotherapy, 58(4), 2240-2248. https://doi.org/10.1128/AAC.01670-13
Wicht, O., Li, W., Willems, L., Meuleman, T. J., Wubbolts, R. W., van Kuppeveld, F. J. M., Rottier, P. J. M., & Bosch, B. J. (2014). Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture. Journal of Virology, 88(14), 7952-7961. https://doi.org/10.1128/JVI.00297-14
Boross, P., van Montfoort, N., Stapels, D. A. C., van der Poel, C. E., Bertens, C., Meeldijk, J., Jansen, J. H. M., Verbeek, J. S., Ossendorp, F., Wubbolts, R., & Leusen, J. H. W. (2014). FcRγ-Chain ITAM Signaling Is Critically Required for Cross-Presentation of Soluble Antibody-Antigen Complexes by Dendritic Cells. Journal of Immunology, 193(11), 5506-5514. https://doi.org/10.4049/jimmunol.1302012
Other output
Boere, J., van de Lest, C., Nolte - t Hoen, E., Libregts, S., Wubbolts, R., de Grauw, J., Malda, J., Wauben, M., & van Weeren, R. (2014). Cartilage homeostasis might be regulated by extracellular vesicles facilitating intercellular communication between joint cells (3). Abstract from NIRM consortium meeting, Rotterdam, Netherlands.
Boere, J., van de Lest, C., Nolte - t Hoen, E., Libregts, S., Wubbolts, R., de Grauw, J., Malda, J., Wauben, M., & van Weeren, R. (2014). Cartilage homeostasis might be regulated by extracellular vesicles facilitating intercellular communication between joint cells (2). Abstract from FEBS workshop: Lipids as Molecular Switches, Island of Spetses, Greece.
Boere, J., van de Lest, C., Nolte - t Hoen, E., Libregts, S., Wubbolts, R., de Grauw, J., Malda, J., Wauben, M., & van Weeren, R. (2014). Cartilage homeostasis might be regulated by extracellular vesicles facilitating intercellular communication between joint cells. Abstract from 1st Matrix Biology Europe (MBE) conference (XXIVth FECTS meeting), Rotterdam, Netherlands.
Boere, J., van de Lest, C., Nolte - t Hoen, E., Libregts, S., Wubbolts, R., de Grauw, J., Malda, J., Wauben, M., & van Weeren, R. (2014). Extracellular vesicles isolated from equine synovial fluid bind to and are internalized by chondrocytes and synoviocytes in vitro. Abstract from International Society for Extracellular Vesicles (ISEV) Annual Meeting, Rotterdam, Netherlands.
Schotanus, B. A., Nantasanti, S., Huch, M., Oosterhoff, L., Fieten, H., Kruitwagen, H. S., van Wolferen, M., Grinwis, G. C. M., Wubbolts, R., Favier, R. P., Penning, L. C., Vries, R. G. J., Clevers, H., Rothuizen, J., & Spee, B. (2014). Wnt AND NOTCH REGULATE PROLIFERATION, MIGRATION AND DIFFERENTIATION OF HUMAN HEPATIC PROGENITOR CELLS AND CANINE LIVER ORGANOIDS: Journal of Hepatology. Journal of Hepatology, 60(1, Suppl), S272. [P610]. https://doi.org/10.1016/S0168-8278(14)60772-8
2013
Scholarly publications
ten Broeke, T., Wubbolts, R., & Stoorvogel, W. (2013). MHC class II antigen presentation by dendritic cells regulated through endosomal sorting. Cold Spring Harbor perspectives in biology, 5(12), a016873. https://doi.org/10.1101/cshperspect.a016873
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Houweling, M., Groot Koerkamp, M. J. A., van Leenen, D., Holstege, F. C. P., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research & Therapy, 15(1), R23. https://doi.org/10.1186/ar4157
Kondylis, V., van Nispen tot Pannerden, H. E., van Dijk, S., ten Broeke, A. G., Wubbolts, R. W., Geerts, W. J. C., Seinen, C. W., Mutis, T., & Heijnen, H. F. G. (2013). Endosome-mediated autophagy: An unconventional MIIC-driven autophagic pathway operational in dendritic cells. Autophagy, Jun 1;9((6)), 861-880. https://doi.org/10.4161/auto.24111.
Aalberts, M., Sostaric, E., Wubbolts, R. W., Wauben, M. H. M., Nolte-'t Hoen, E. N. M., Gadella, B. M., Stout, T. A. E., & Stoorvogel, W. (2013). Spermatozoa recruit prostasomes in response to capacitation induction. Biochimica et Biophysica Acta-Proteins Proteomics, 1834((11)), 2326-2335. https://doi.org/10.1016/j.bbapap.2012.08.008
2012
Scholarly publications
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Identification of a novel biomolecular target for regeneration of the degenerated canine intervertebral disc. In Proceedings 25th annual symposium of the European Society of Veterinary Neurology (ECVN) and European College of Veterinary Neurology (ESVN) (pp. 14-14)
Kuijk, E. W., van Tol, L. T. A., Van de Velde, H., Wubbolts, R., Welling, M., Geijsen, N., & Roelen, B. A. J. (2012). The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos. Development (Cambridge, England), 139(5), 871-882. https://doi.org/10.1242/dev.071688
Smolders, L. A., Meij, B. P., Riemers, F. M., Licht, R., Wubbolts, R. W., van den Heuvel, D. J., Grinwis, G. C. M., Vernooij, H., Hazewinkel, H. A. W., Penning, L. C., & Tryfonidou, M. A. (2012). Canonical Wnt Signaling in the Notochordal Cell is Upregulated in Early Intervertebral Disk Degeneration. Journal of Orthopaedic Research, 30(6), 950-957. https://doi.org/10.1002/jor.22000
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration suggests a crucial role of caveolin-1 in notochordal cell preservation. In Proceedings European Veterinary Conference Voorjaarsdagen 2012 (pp. 236-237)
2011
Scholarly publications
ten Broeke, A. G., van Niel, G., Wauben, M. H. M., Wubbolts, R. W., & Stoorvogel, W. (2011). Endosomally stored MHC Class II does not contribute to antigen presentation by dendritic cells at inflammatory conditions. Traffic, 12, 1025-1036.
Tryfonidou, M. A., Lunstrum, G. P., Hendriks, K., Riemers, F. M., Wubbolts, R. W., Hazewinkel, H. A. W., Degnin, C. R., & Horton, W. A. (2011). Novel type II collagen reporter mice: New tool for assessing collagen 2α1 expression in vivo and in vitro. Developmental Dynamics, Mar(240 (3)), 663-673.
2010
Scholarly publications
Kuijk, E., van Tol, A., van der Velde, H., Wubbolts, R. W., Geijsen, N., & Roelen, B. A. J. (2010). Functional differences between bovine and human embyos in the development of the pluripotent epiblast and primitve endoderm. In Proceedings of the 4th International Symposium on Stem Cells, Development and Regulation, Amsterdam
ten Broeke, A. G., de Graaff, A. M., van 't Veld, E. M., Wauben, M. H. M., Stoorvogel, W., & Wubbolts, R. W. (2010). Trafficking of MHC Class II in dendritic cells is dependent on but not regulated by degradation of its associated invariant chain. Traffic, 11, 324-331.
Other output
ten Broeke, A. G., van Niel, G., Wauben, M. H. M., Wubbolts, R. W., & Stoorvogel, W. (2010). Newly synthesized and not endosomally stored MHC class II is used for antigen presentation by dendritic cells at inflammatory conditions.. Abstract from DC2010: Forum on vaccine science.
Kuijk, E. W., van der Velde, H., van Tol, H. T., Wubbolts, R. W., & Roelen, B. A. J. (2010). FGF/MAPK-signaling directs the development of the pluripotent cell population in bovine and human embryos. Abstract from ISSCR 8th Annual Meeting San Francisco CA, USA.
2009
Scholarly publications
Buschow, S. I., Nolte-'t Hoen, E. N. M., van Niel, G., Pols, M. S., ten Broeke, A. G., Lauwen, M., Ossendorp, F., Melief, C. J. M., Raposo, G., Wubbolts, R. W., Wauben, M. H. M., & Stoorvogel, W. (2009). MHC II in dendritic cells is targeted to lysosomes or T Cell-Induced exosomes via distinct multivesicular body pathways. Traffic, 10, 1528-1542.
2008
Scholarly publications
van Niel, G. C. V., Wubbolts, R. W., & Stoorvogel, W. (2008). Endosomal sorting of MHC class II determines antigen presentation by dendritic cells. Current Opinion in Cell Biology, 20(4), 437-444.
Other output
ten Broeke, A. G., de Graaff, A. M., Stoorvogel, W., & Wubbolts, R. W. (2008). Degradation of MHC class II associated invariant chain in dendritic cells is not developmentally regulated.. Poster session presented at NVVI jaarvergadering, Noordwijkerhout.
2006
Scholarly publications
van Niel, G. C. V., Wubbolts, R. W., ten Broeke, A. G., Buschow, S. I., Ossendorp, F. A., Melief, C. J. M., Raposo, G., van Balkom, B. W. M., & Stoorvogel, W. (2006). Dendritic cells regulate exposure of MHC Class II at their plasma membrane by oligoubiquitination. Immunity, 25, 885-894.
2005
Scholarly publications
Buschow, S. I., Liefhebber, J. M., Wubbolts, R. W., & Stoorvogel, W. (2005). Exosomes contain ubiquitinated proteins. Blood Cells, Molecules, & Diseases, 35, 398-403.
2003
Scholarly publications
Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J-W., Geuze, H. J., & Stoorvogel, W. (2003). Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation. Journal of Biological Chemistry, 278(13), 10963-72. https://doi.org/10.1074/jbc.M207550200
2001
Scholarly publications
Jordens, I., Fernandez-Borja, M., Marsman, M., Dusseljee, S., Janssen, L., Calafat, J., Janssen, H., Wubbolts, R., & Neefjes, J. (2001). The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors. Current Biology, 11(21), 1680-5.
1999
Scholarly publications
Fernandez-Borja, M., Wubbolts, R., Calafat, J., Janssen, H., Divecha, N., Dusseljee, S., & Neefjes, J. (1999). Multivesicular body morphogenesis requires phosphatidylinositol 3-kinase activity. Current Biology, 9(1), 55-58. https://doi.org/10.1016/S0960-9822(99)80048-7
Wubbolts, R., Fernandez-Borja, M., Jordens, I., Reits, E., Dusseljee, S., Echeverri, C., Vallee, R. B., & Neefjes, J. (1999). Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments. Journal of Cell Science, 112 ( Pt 6), 785-95.
Wubbolts, R., & Neefjes, J. (1999). Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors. Immunological Reviews, 172, 189-208.
1998
Scholarly publications
Dusseljee, S., Wubbolts, R., Verwoerd, D., Tulp, A., Janssen, H., Calafat, J., & Neefjes, J. (1998). Removal and degradation of the free MHC class II beta chain in the endoplasmic reticulum requires proteasomes and is accelerated by BFA. Journal of Cell Science, 111 ( Pt 15), 2217-2226.
1997
Scholarly publications
Wubbolts, R., Fernandez-Bona, M., & Neefjes, J. (1997). MHC class II molecules: transport pathways for antigen presentation. Trends in Cell Biology, 7(3), 115-8. https://doi.org/10.1016/S0962-8924(97)01000-3
1996
Scholarly publications
Neisig, A., Wubbolts, R., Zang, X., Melief, C., & Neefjes, J. (1996). Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing. Journal of Immunology, 156(9), 3196-206.
Wubbolts, R., Fernandez-Borja, M., Oomen, L., Verwoerd, D., Janssen, H., Calafat, J., Tulp, A., Dusseljee, S., & Neefjes, J. (1996). Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface. Journal of Cell Biology, 135(3), 611-22.
1995
Scholarly publications
Gebbink, M. F. B. G., Zondag, G. C. M., Koningstein, G. M., Feiken, E., Wubbolts, R. W., & Moolenaar, W. H. (1995). Cell surface expression of receptor protein tyrosine phosphatase RPTPμ is regulated by cell-cell contact. Journal of Cell Biology, 131(1), 251-260. https://doi.org/10.1083/jcb.131.1.251
1994
Scholarly publications
Calafat, J., Nijenhuis, M., Janssen, H., Tulp, A., Dusseljee, S., Wubbolts, R., & Neefjes, J. (1994). Major histocompatibility complex class II molecules induce the formation of endocytic MIIC-like structures. Journal of Cell Biology, 126(4), 967-977. https://doi.org/10.1083/jcb.126.4.967
1993
Scholarly publications
Gebbink, M. F., Zondag, G. C., Wubbolts, R. W., Beijersbergen, R. L., van Etten, I., & Moolenaar, W. H. (1993). Cell-cell adhesion mediated by a receptor-like protein tyrosine phosphatase. Journal of Biological Chemistry, 268(22), 16101-4.
1991
Scholarly publications
Medema, R. H., Wubbolts, R., & Bos, J. L. (1991). Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression. Molecular and Cellular Biology, 11(12), 5963-7.