Dr. R. (Rita) Petracca

Assistant Professor
Chemical Biology and Drug Discovery
r.petracca@uu.nl

EDUCATION


January 2013 - December 2016: PhD student in medicinal chemistry, Drug Discovery and Development Department (D3), Istituto Italiano di Tecnologia, Genova (GE), Italy. 
Title of thesis: Design and synthesis of new beta-lactam N-Acylethanolamine Acid Amidase (NAAA) inhibitors
Advisors: Dr. Fabio Bertozzi; Dr. Tiziano Bandiera, Prof. Daniele Piomelli

February 2015 - May 2016: PhD visiting student in carbohydrate chemistry and chemical biology, Bio-organic synthesis group, Department of chemistry, Faculty of science, Universiteit Leiden, Leiden, The Netherlands.
Title of project: Synthesis and biological evaluation of a novel alpha-L-arabinopyranose-configured Activity Based Probe (ABP)
Advisor: Prof. H. S. Overkleeft

October 2006 - December 2011: MSc degree in Pharmaceutical Chemistry and Technologies, Pharmaceutical and Biomedical Sciences Department – EpigeneticMedChemLab, Faculty of Pharmacy, University of Salerno (SA), Italy. 
Title of thesis: Design and synthesis of novel inhibitors of Arginine Methyltransferase 1 (PRMT1)
Advisor: Prof. G. Sbardella


ACADEMIC POSITIONS 


September 2021 – September 2022: Research Associate in chemical biology, Department of Chemistry, Molecular Sciences Research Hub (MSRH), Imperial College London, London, United Kingdom.
Title of the project: Design and Synthesis of Potent Macrocyclic Peptides for Rab27a engagement in cells
Advisor: Prof. E. W. Tate

September 2019 – August 2021: Postdoctoral Marie Sklodowska-Curie Fellow in chemical biology, Department of Chemistry, Molecular Sciences Research Hub (MSRH), Imperial College London, London, United Kingdom.
Title of the project: RaPID Selection of Novel Macrocyclic Peptides as Modulators of Rab27a-effector Interactions
Advisor: Prof. E. W. Tate

May 2017 - August 2019: Postdoctoral GODIP Fellow in protein/peptide chemistry, School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin (TCD), Dublin 2, Ireland.
Title of the project: Thiol-ene mediated protein ligation and elimination (TEMPLE): a novel ligation methodology for chemical ubiquitination of proteins
Advisor: Prof. E. M. Scanlan


February 2017 - April 2017: Postdoctoral Fellow in peptide/medicinal chemistry, Institut für Chemie/FG Organische Chemie, Technische Universität Berlin, Berlin, Germany.
Title of the project: Design and synthesis of novel drug-like Albicidin derivatives
Advisor: Prof. R. Suessmuth


June 2012 - December 2012: Research Internship in medicinal chemistry, Drug Discovery and Development Department (D3), Istituto Italiano di Tecnologia (IIT), Genova (GE), Italy.
Title of project: Design and synthesis of new beta-lactones as N-Acylethanolamine Acid Amidase (NAAA) inhibitors
Advisors: Dr. Stefano Ponzano, Dr. Fabio Bertozzi


January 2012 - May 2012: Graduate Researcher in organic/medicinal chemistry, Pharmaceutical and Biomedical Sciences Department, EpigeneticMedChemLab, Faculty of Pharmacy, Università di Salerno (SA), Italy.
Title of project: Synthesis and biological evaluation of phenolic and naptholic derivates as potential inhibitors of Arginine Methyltransferase 1 (PRMT1)
Advisors: Prof. S. Castellano, Prof. G. Sbardella