Academia
August 2021 to present: Associate Professor, Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
September 2016 to July 2021: Assistant Professor, Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
November 2014 to August 2016: Senior Scientist, Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands (Advisor: Prof Roland J. Pieters)
March 2012 to October 2014 - Postdoctoral Fellow, departments of Cell and Molecular Biology, Chemical Physiology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA, USA (Advisor: Prof. James C. Paulson)
PhD in Virology Nov 2007 – Dec 2011, Virology Department, Faculty of Veterinary
Medicine, Utrecht University, Utrecht, The Netherlands
Soluble trimeric hemagglutinins to study receptor binding and
immunogenic properties. June 21st 2012
Promotor: Prof. P.J. Rottier
Co-Promotor: Xander de Haan
MS in Biomedical Science, 2007, University of Amsterdam
BS in Biomedical Science, 2005, University of Amsterdam
Grants and Fellowships
2023: Mizutani Foundation for Glycoscience Research Grant (€30k)
ESCMID Research Grant (€20k)
2022: FLU-SWITCH ICRAD (€150k)
ERC_POC Sugar enabledVAC (€150k)
CSC fellowship (Ruonan Liang)
NWO grant for international meetings for the Joint Glycobiology Meeting 2022 in Utrecht
2021: NWO-M2 (€700k) (With Jurriaan Huskens UTwente)
2020: NWO Take Off (€40k)
2020: VetBioNet (€100k) (With Sander Herfst and Mariette Ducatez)
2020: ESWI best body of work award (€10k)
2019: Beijerinck Premium from the Royal Dutch Academy of Sciences (€25k)
2018: ERC_STG Sugar Enable (€1,5M)
2016: NWO-LIFT with Friesland Campina (€250k) (Co-PI with Prof. G.J. Boons)
2014: NWO VENI Fellowship (€250k)
2012: NWO Rubicon Fellowship (€109k)
2007: Organon Pharmaceuticals/Dr. Saal van Zwanenberg Fellowship
REFEREED PUBLICATIONS
79. Li T, Spruit CM, Wei N, Liu L, Wolfert MA, de Vries RP#, Boons GJ#
Chemistry - A European Journal (2024)
Chemoenzymatic synthesis of tri-antennary N-glycans terminating in sialyl-lewis X reveals the importance of glycan complexity for influenza A virus receptor binding
78. Tomris I, van der Woude R, de Paiva Droes Rocha R, Torrents de la Peña A, Ward AB, de Vries RP#
Protein Science (2024)
Viral envelope proteins fused to multiple distinct fluorescent reporters to probe receptor binding
77. Vigeveno RM, Han AX, de Vries RP, Parker E, de Haan K, van Leeuwen S, Hulme KD, Lauring AS, te Velthuis AJ, Boons GJ, Fouchier RA, Russell CA, de Jong MD, Eggink D
Virus Evolution (in press)
Long term evolution of human seasonal influenza virus A(H3N2) is associated with an increase in polymerase complex activity.
76. Spruit CM, Palme DI, Li T, Ríos Carrasco M, Gabarroca García A, Sweet I, Kuryshko M, Maliepaard JC, Reiding KR, Scheibner D, Boons GJ, Abdelwhab EM, de Vries RP#
Journal of Virology (2024)
Complex N-glycans are important for interspecies transmission of H7 influenza A viruses
75. Wu Y, Bosman GP, Chapla D, Huang C, Moremen KW, de Vries RP, Boons GJ
Journal of the American Chemical Society (2024)
A biomimetic synthetic Strategy can provide keratan sulfate I and II oligosaccharides with diverse fucosylation and sulfation patterns
74. Unione L# , Ammerlaan AN, Bosman GP, Uslu E, Liang R, Broszeit F, van der Woude R, Liu Y, Ma S, Liu L, Marcos Gómez-Redondo, Iris A Bermejo, Pablo Valverde, Diercks T, Arda A, de Vries RP#, Boons GJ#
Nature Communications (2024)
Probing altered receptor specificities of antigenically drifting human H3N2 viruses by chemoenzymatic synthesis, NMR, and modeling
73. de Jong SP, Felix Garza ZS, Gibson J, van Leeuwen S, de Vries RP, Boons GJ, van Hoesel M, de Haan K, van Groeningen L, Hulme KD, van Willigen HD, Wynberg E, de Bree GJ, Matser A, Bakker M, van der Hoek L, Prins M, Kootstra NA, Eggink D, Nichols BE, Han AX, de Jong MD, Russell CA
Nature Communications (2024)
Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation
72. Ma S, Liu L, Eggink D, Herfst S , Fouchier RA, de Vries RP, Boons GJ
Journal of the American Chemical Society AU (2024)
Asymmetrical bi-antennary glycans prepared by a stop-and-go strategy reveal receptor binding evolution of human influenza A viruses
71. Grawe A, Spruit CM, de Vries RP, Merkx M
RSC Chemical Biology (2024)
Bioluminescent detection of viral surface proteins using branched multivalent protein switches
70. Vos GM, Wu Y, van der Woude R, de Vries RP, Boons GJ
Chemistry - A European Journal (2023)
Chemo-enzymatic synthesis of isomeric I-branched polylactosamines using traceless blocking groups
69. Vos GM, Hooijschuur KC, Li Z, Fjeldsted J, Klein C, de Vries RP, Toraño JS, Boons GJ.
Nature Communications (2023)
Sialic acid O-acetylation patterns and glycosidic linkage type determination by ion mobility-mass spectrometry
68. Wu Y, Vos GM, Huang C, Chapla D, Kimpel AL, Moremen KW, de Vries RP, Boons GJ
Journal of the American Chemical Society AU (2023)
Exploiting substrate specificities of 6-O-sulfotransferases to enzymatically synthesize keratan sulfate oligosaccharides
67. Kutter JS, Linster M, de Meulder D, Bestebroer TM, Lexmond P, Rosu ME, Richard M, de Vries RP, Fouchier RA, Herfst S
Journal of General Virology (2023)
Continued adaptation of A/H2N2 viruses during pandemic circulation in humans
66. Spruit CM, Sweet IR, Maliepaard JC, Bestebroer T, Lexmond P, Qiu B, Damen MJ, Fouchier RA, Reiding KR, Snijder J, Herfst S, Boons GJ, de Vries RP#
Glycobiology (2023)
Contemporary human H3N2 influenza A viruses require a low threshold of suitable glycan receptors for efficient infection
65. Tomris I, Unione L, Nguyen L, Zaree P, Bouwman KM, Liu L, Li Z, Fok JA, Ríos Carrasco M, van der Woude R, Kimpel AL, Linthorst MW, Kilavuzoglu SE, Verpalen EC, Caniels TG, Sanders RW, Heesters BA, Pieters RJ, Jiménez-Barbero J, Klassen JS, Boons GJ, de Vries RP#
ACS Chemical Biology (2023)
SARS-CoV-2 spike N-terminal domain engages 9-O-acetylated α2-8-linked sialic acids
64. Sun L, Chopra P, Tomris I, van der Woude R, Liu L, de Vries RP, Boons GJ
Journal of the American Chemical Society AU (2023)
Well-defined heparin mimetics can inhibit the binding of the trimeric spike of SARS-CoV-2 in a length-dependent manner
63. Zaree P, Tomris I, de Vos SD, van der Woude R, Flesch FM, Klein Gebbink RJ, de Vries RP, Pieters RJ
RSC advances (2023)
Facile electrochemical affinity measurements of small and large molecules
62. Canales A#, Sastre J, Orduña JM, Spruit CM, Pérez-Castells J,Domínguez G, Bouwman KM, van der Woude R, Cañada JF, Nycholat CM, Paulson JC, Boons GJ, Jiménez-Barbero J, de Vries RP#
Journal of the American Chemical Society AU (2023)
Revealing the specificity of human H1 influenza A viruses to complex N-glycans
61. Scheibner D, Salaheldin AH, Bagato O, Zaeck LM, Mostafa A, Blohm U, Müller C, Eweas AF, Franzke K, Karger A, Schäfer A, Gischke M, Hoffmann D, Lerolle S, Li X, Abd El-Hamid HS, Veits J, Breithaupt A, Boons GJ, Matrosovich M, Finke S, Pleschka S, Mettenleiter TC, de Vries RP, Abdelwhab EM
Plos Pathogens (2023)
Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses
60. Konietzny PB, Peters H, Hofer ML, Gerling-Driessen UI, de Vries RP, Peters T, Hartmann L
Macromolecular Bioscience (2022)
Enzymatic sialylation of synthetic multivalent scaffolds: from 3’-sialyllactose glycomacromolecules to novel neoglycosides
59. Nemanichvili N, Spruit CM, Berends AJ, Gröne A, Rijks JM, Verheije MH, de Vries RP#
Glycobiology (2022)
Wild and domestic animals variably display Neu5Ac and Neu5Gc sialic acids
58. Tomris I, Bouwman KM, Adolfs Y, Noack D, van der Woude R, Kerster G, Herfst S, Sanders RW, van Gils MJ, Boons GJ, Haagmans BL, Pasterkamp RJ, Rockx B, de Vries RP#
Plos Pathogens (2022)
Distinct spatial arrangements of ACE2 and TMPRSS2 expression in Syrian hamster lung lobes dictates SARS-CoV-2 infection patterns
57. Spruit CM, Zhu X, Tomris I, Ríos Carrasco M, Broszeit F, Han AX, der Woude R, Bouwman KM, Luu MT, Matsuno K, Sakoda Y, Russell CA, Wilson IA, Boons GJ, de Vries RP#
Journal of Virology (2022)
N-glycolylneuraminic acid binding of avian and equine H7 influenza A viruses
56. Gaide N, Lucas M, Delpont M, Croville G, Bouwman KM, Papanikolaou A, van der Woude R, Gagarinov IA, Boons GJ, de Vries RP, Volmer R, Teillaud A, Vergne T, Bleuart C, Le Loc’h G, Delverdier M, Guérin J
Veterinary Research (2022)
Comparative pathobiological study of highly pathogenic avian influenza virus H5Nx on naturally infected Galliformes and Anseriformes with glycobiological correlates
55. Li Z, Unione L, Liu L, Lang Y, de Vries RP, de Groot RJ, Boons GJ
Journal of the American Chemical Society (2022)
Synthetic O-acetylated sialosides and their acetamido-deoxy analogues as probes for coronaviral hemagglutinin-esterase recognition.
54. Nemanichvili N, Berends AJ, Tomris I, Barnard KM, Parrish CA, Gröne A, Rijks JM, Verheije MH, de Vries RP#
Veterinary Microbiology (2022)
Influenza D binding properties vary amongst the two major virus clades and wildlife
53. Nguyen L, McCord KA, Bui DT, Bouwman KM, Kitova EN, Elaish M, Kumawat D, Daskhan GC, Tomris I, Han L, Chopra P, Yang TJ, Willows SD, Mason AL, Mahal LK, Lowary TL, West LJ, Hsu SD, Hobman T, Tompkins SM, Boons GJ, de Vries RP, Macauley MS, Klassen JS
Nature Chemical Biology (2022)
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2
52. Arunkumar GA, Bhavsar D, Li T, Strohmeier S, Chromikova V, Amanat F, Bunyatov M, Wilson PC, Ellebedy AH, Boons GJ, Simon V, de Vries RP, Krammer F
Nature Communications (2021)
Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus
51. Broszeit F, van Beek RJ, Unione L, Bestebroer TM, Chapla D, Yang J, Moremen KW, Herfst S, Fouchier RA, de Vries RP#, Boons GJ#
Nature Communications (2021)
Glycan remodeled erythrocytes facilitate antigenic characterization of recent A/H3N2 influenza viruses
50. Heesters BA, van Megesen K, Tomris I, de Vries RP, Magri G, Spits H
Journal of Experimental Medicine (2021)
Characterization of human FDCs reveals regulation of T cells and antigen presentation to B cells
49. Liu L, Chopra P, Li X, Bouwman KM, Tompkins SM, Wolfert MA, de Vries RP, Boons GJ
ACS Central Science (2021)
Heparan sulfate proteoglycans as an attachment factor for SARS-CoV-2
48. Spruit CM, Nemanichvili N, Okamatsu M, Takematsu H, Boons GJ, and de Vries RP#
Viruses (2021)
N-glycolylneuraminic acid in animal models for human influenza A virus
47. Nemanichvili N, Berends AJ, Wubbolts RW, Gröne A, Rijks JM, de Vries RP#, and Verheije MH
Viruses (2021)
Tissue microarrays to visualize influenza D attachment to host receptors in the respiratory tract of farm animals
46. Bouwman KM, Tomris I, Turner HL, van der Wouder R, Shamorkina TM, Bosman GP, Herfst S, Rockx B, Snijder J, Haagmans BL, Ward AB, Boons GJ, de Vries RP#
Plos Pathogens (2021)
Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins
45. Overeem N, Hamming E, Grant O, Di Iorio L, Tieke M, Bertolino C, Li Z, Vos G, de Vries RP, Woods RJ, Tito N, Boons GJ, van der Vries E, Huskens J.
ACS Central Science (2020)
Hierarchical multivalent effects control influenza host specificity.
44. van der Woude R, Turner HL, Tomris I, Bouwman KM, Ward AB, de Vries RP#
Protein Science (2020)
Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells
43. Eggink D, Spronken MI, van der Woude R, Buzink J, Broszeit F, McBride R, Pawestri H, Setiawaty V, Paulson JC, Boons GJ, Fouchier RA, Russell CA, de Jong MD, de Vries RP
Journal of Virology (2020)
Phenotypic effects of substitutions within the receptor binding site of highly pathogenic avian influenza H5N1 observed during human infection.
42. Kikutani Y, Okamatsu M, Nishihara S, Takase-Yoden S, Hiono T, de Vries RP, McBride R, Matsuno K, Kida H, Sakoda Y
Microbiology & Immunology (2020)
E190V substitution of H6 hemagglutinin is one of key factors for binding to sulfated sialylated glycan receptor and infection to chickens
41. Figueroa T, Bessière P, Coggon A, Bouwman KM, van der Woude R, Delverdier M, Verheije MH, de Vries RP, Volmer R
Journal of Virology (2020)
The intestinal microbiota contributes to the control of highly pathogenic H5N9 influenza virus replication in ducks.
40. Parsons L, An Y, Qi L, White M, van der Woude R, Hartshorn K, Taubenberger JK, de Vries RP, Cipollo JF.
Journal of Virology (2019)
Influenza Hemagglutinins H2, H5, H6, and H11 are not Targets of Pulmonary Surfactant Protein D: N-glycan subtypes in host-pathogen interactions.
39. Bouwman KM, Parsons LM, Berends AJ, de Vries RP, Cipollo JF, Verheije MH.
Journal of Virology (2019)
Three Amino Acid Changes In Avian Coronavirus Spike Protein Allows Binding To Kidney Tissue.
38. Lu W, Du W, Jesús Somovilla V, Yu G, Haksar D, de Vries E, Boons GJ, de Vries RP, de Haan CA, Pieters RJ.
Journal of Medicinal Chemistry (2019)
Enhanced Inhibition of Influenza A virus adhesion by Di- and Trivalent Hemagglutinin Inhibitors
37. Broszeit F, Tzarum N, Zhu X, Nemanichvili N, Eggink D, Leenders T, Li Z, Liu L, Wolfert MA, Papanikolaou A, Martínez-Romero C, Gagarinov IA, Yu W, García-Sastre A, Wennekes T, Okamatsu M, Verheije MH, Wilson IA, Boons GJ, de Vries RP#
Cell Reports (2019)
N-glycolylneuraminic acid as a receptor for influenza A viruses
36. Gagarinov IA, Li T, Wei N, Sastre Toraño J, de Vries RP, Wolfert MA, Boons GJ,
Angew Chem Int Ed Engl. (2019)
Protecting Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives.
35. Parsons LM, Bouwman KM, Azurmendi H, de Vries RP, Cipollo JF, Verheije MH
Journal of Biological Chemistry (2019)
Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding
34. Aldosari MH, de Vries RP, Rodriguez LR, Hesen NA, Beztsinna N, van Kuilenburg AB, Hollak CE, Schellekens H, Mastrobattista E
European Journal of Pharmaceutics and Biopharmaceutics (2019)
Liposome-targeted recombinant human acid sphingomyelinase: Production, formulation, and in vitro evaluation
33. Bouwman KM, Delpont M, Broszeit F, Berger R, Weerts EA, Lucas MN, Delverdier M, Belkasmi S, Papanikolaou A, Boons GJ, Guérin JL, de Vries RP, Ducatez MF, Verheije MH
Journal of Virology (2019)
Guinea fowl coronavirus diversity has phenotypic consequences for glycan and tissue binding
32. Thompson AJ, de Vries RP, Paulson JC
Current Opinion in Virology (2019)
Virus recognition of glycan receptors
31. Nemanichvili N, Tomris I, Turner HL, McBride R, Grant OC, van der Woude R, Aldosari MH, Pieters RJ, Woods RJ , Paulson JC, Boons GJ, Ward AB, Verheije MH and de Vries RP†
Journal of Molecular Biology (2018)
Fluorescent trimeric hemagglutinins reveal multivalent receptor binding properties
30. Peng W, Bouwman KM, McBride R, Grant OC, Woods RJ, Verheije MH, Paulson JC, de Vries RP#
Journal of Virology (2018)
Enhanced human-type receptor binding by ferret transmissible H5N1 with a K193T mutation
29. de Vries RP, Tzarum N, Peng W, Thompson AJ, Wickramasinghe IN, Zhu X, McBride R, Torrents de la Pena A, van Breemen M, Yu W, Sanders RW, Verheije MH, Wilson IA, Paulson JC
EMBO Molecular Medicine (2017)
A single mutation in Taiwanese H6N1 influenza promotes binding to human-type receptors
28. de Vries RP, Peng W, Zhu X, Thompson AJ, Wickramasinghe IN, Bouwman K, Torrents de la Pena AT, van Breemen MJ, de Haan CA, Yu W, McBride R, Sanders RW, Woods RJ, Verheije MH, Wilson IA, Paulson JC
Plos Pathogens, (2017)
Three mutations switch H7N9 influenza to human-type receptor specificity
27. Tzarum N, Vries RP, Peng W, Thompson AJ, Bouwman KM, McBride RM, Yu W, Zhu X, Verheije MH, Paulson JC, Wilson IA
Cell Reports, (2017)
The 150-Loop Restricts the Host Specificity of Human H10N8 Influenza Virus
26. Peng W*, de Vries RP*, Grant OC, Thompson AJ, McBride R, Tsogtbaatar B, Lee PS, Razi N, Wilson IA, Woods RJ, Paulson JC
Cell Host & Microbe, (2017)
*Contributed Equally
Recent H3N2 Viruses Have Evolved Specificity for Extended, Branched Hyman-type Receptors, Conferring Potential for Increased Avidity
25. Parsons LM, An Y, de Vries RP de Haan CA , Cipollo JF
Journal of Proteome Research, (2016)
Glycosylation characterization of an influenza H5N7 hemagglutinin series with engineered glycosylation patterns: Implications for structure-function relationships
24. McBride R, Paulson JC, de Vries RP†
Journal of Visualized Experiments, (2016)
A miniaturized glycan microarray assay for assessing the avidity and specificity of influenza virus hemagglutinins
23. Hiono T, Okamatsu M, Igarashi M, McBride R, de Vries RP, Paulson JC, Sakoda Y, Kida H
Archives of Virology (2016)
The amino acids at positions 222 and 227 of the haemagglutinin together with the neuraminidase determine binding of H5 avian influenza viruses to fucosylated a2,3 sialosides
22. Ambepitiya Wickramasinghe IN, de Vries RP, Weerts EA, van Beurden S, Peng W, McBride R, Ducatez M, Guy J, Brown P, Eterradossi N, Gröne A, Paulson JC, Verheije MH
Journal of Virology (2015)
Novel receptor specificity of avian gammacoronaviruses causing enteritis.
21. Ambepitiya Wickramasinghe IN, de Vries RP, Eggert AM, Wandee N,de Haan CA, Gröne A, Verheije MH
Plos One (2015)
Elucidation of host tissue and glycan binding specificities of avian viral attachment proteins using novel avian tissue microarrays.
20. Zhang H*, de Vries RP*, Tzarum N*, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA
Cell Host Microbe. (2015)
*Contributed Equally
Human-infecting H10N8 influenza virus retains strong preference for avian-type receptors.‡
19. Tzarum N, de Vries RP, Zhu X, Yu W, McBride R, Paulson JC, Wilson IA.
Cell Host Microbe. (2015)
Structure and receptor binding of the hemagglutinin from a human H6N1 influenza virus.‡
‡Back-to-back papers
18. de Vries RP, ZhuX, McBride R, Hanson A, Rigter A, Zhong G,Xu R, Yu W, Kawaoka Y, de Haan CA, Wilson IA, Paulson JC
Journal of Virology (2014)
Hemagglutinin receptor specificity and structural analyses of aerosol transmissible H5N1 viruses.
17. Nycholat CM, Peng W, McBride R, Antonopoulos A, de Vries RP, Polonskaya Z, Finn MG, Dell A, Haslam SM, Paulson JC.
Journal of the American Chemical Society (2013)
Synthesis of biologically active N- and O-linked glycans with multisialylated poly-N-acetyllactosamine extensions using P. damsela a2-6 sialyltransferase.
16. Xu R, de Vries RP, Zhu X, Nycholat CM, McBride R, YuW, Paulson JC, Wilson IA
Science (2013)
Preferential recognition of avian-like receptors in human H7N9 viruses.
15. de Vries RP, de Vries E, Martínez-Romero C, McBride R, van Kuppeveld F, Rottier PJ, García-Sastre A, Paulson JC, de Haan CA
Journal of Virology (2013)
Evolution of the hemagglutinin protein of new pandemic H1N1 virus: Maintaining optimal receptor binding by compensatory substitutions.
14. Watanabe T, Kiso M, Fukuyama S, Nakajima N, Imai M, Yamada S, Murakami S, Yamayoshi S, Iwatsuki-Horimoto K, Sakoda Y, Takashita E, McBride R, Noda T, Hatta M, Imai H, Zhao D, Kishida, N., Shirakura, M, de Vries RP, Shichinohe S, Okamatsu M, Tamura T, Tomita Y, Fujimoto N, Goto K, Katsura H, Kawakami E, Ishikawa I, Watanabe S, Ito M, Sakai-Tagawa Y, Sugita Y, Uraki R, Yamaji R, Eisfeld AJ, Zhong G, Fan S, Ping J, Maher EA, Hanson A, Uchida Y, Saito T, Ozawa M, Neumann G, Kida H, Odagiri T, Paulson JC, Hasegawa H, Tashiro M, Kawaoka Y
Nature. (2013)
Characterization of H7N9 influenza A viruses isolated from humans.
13. Wang Z, Chinoy ZS, Ambre SG, Peng W, McBride R, de Vries RP, Glushka J, Paulson JC, Boons GJ.
Science. 2013
A General Strategy for the Chemoenzymatic Synthesis of Asymmetrically Branched N-Glycans.
12. Paulson JC, de Vries RP
Virus Research. (2013)
H5N1 receptor specificity as a factor in pandemic risk.
11. de Vries RP, Smit CH, de Bruin E, Rigter A, de Vries E, Cornelissen LA, Eggink D, Chung NP, Moore JP, Sanders RW, Hokke CH, Koopmans M, Rottier PJ, de Haan CA
Journal of Virology (2012)
Glycan-dependent immunogenicity of recombinant soluble trimeric hemagglutinin.
10. Cornelissen, LA, de Leeuw OS, Tacken MG, Klos HC, de Vries RP, de Boer-Luijtze EA, van Zoelen-Bos DJ, Rigter A, Rottier PJ, Moormann RJ, de Haan CA
PLoS One. (2012)
Protective efficacy of newcastle disease virus expressing soluble trimeric hemagglutinin against highly pathogenic H5N1 influenza in chickens and mice.
9. de Vries E, de Vries RP, Wienholts MJ, Floris CE, Jacobs MS, van den Heuvel A, Rottier PJ, de Haan CA
PNAS. (2012)
Influenza A virus entry of cells lacking sialylated N-glycans.
8. Ambepitiya Wickramasinghe I, de Vries RP, Grone R, de Haan CA, Verheije M.
Journal of Virology. (2011)
Binding of avian coronavirus spike proteins to host factors reflects virus
tropism and pathogenicity.
7. Melchers M, Matthews K, de Vries RP, Eggink D, van Montfort T, Bontjer I, van de Sandt C, David K, Berkhout B, Moore JP, Sanders RW.
Retrovirology. (2011)
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand that
activates dendritic cells.
6. Loeffen WL, de Vries RP, Stockhofe N, van Zoelen-Bos D, Maas R, Koch G, Moormann RJ, Rottier PJ, de Haan CA.
Vaccine (2011 )
Vaccination with a soluble recombinant hemagglutinin trimer protects pigs against a challenge with pandemic (H1N1) 2009 influenza virus.
5. de Vries RP, de Vries E, Moore KS, Rigter A, Rottier PJ, de Haan CA.
Journal of Biological Chemistry (2011)
Only two residues are responsible for the dramatic difference in receptor binding between swine and new pandemic H1 hemagglutinin.
4. Bosch BJ*, Bodewes R*, de Vries RP*, Kreijtz JH, Bartelink W, van Amerongen G, Rimmelzwaan GF, de Haan CA, Osterhaus AD, Rottier PJ.
*Contributed Equally
Journal of Virology (2010)
Recombinant soluble, multimeric HA and NA exhibit distinctive types of protection against pandemic swine-origin 2009 A(H1N1) influenza virus infection in ferrets.
3. Cornelissen LA, de Vries RP, de Boer-Luijtze EA, Rigter A, Rottier PJ, de Haan CA.
PLoS One (2010)
A single immunization with soluble recombinant trimeric hemagglutinin protects chickens against highly pathogenic avian influenza virus H5N1.
2. de Vries RP, de Vries E, Bosch BJ, de Groot RJ, Rottier PJ, de Haan CA.
Virology (2010)
The influenza A virus hemagglutinin glycosylation state affects receptor-binding specificity.
1. Crooks ET, Moore PL, Franti M, Cayanan CS, Zhu P, Jiang P, de Vries RP, Wiley C, Zharkikh I, Schülke N, Roux KH, Montefiori DC, Burton DR, Binley JM.
Virology. (2007)
A comparative immunogenicity study of HIV-1 virus-like particles bearing various forms of envelope proteins, particles bearing no envelope and soluble monomeric gp120.