Publications
2022
Scholarly publications
Rijcken, C. J. F., De Lorenzi, F., Biancacci, I., Hanssen, R. G. J. M., Thewissen, M., Hu, Q., Atrafi, F., Liskamp, R. M. J., Mathijssen, R. H. J., Miedema, I. H. C., Menke - van der Houven van Oordt, C. W., van Dongen, G. A. M. S., Vugts, D. J., Timmers, M., Hennink, W. E., & Lammers, T. (2022). Design, development and clinical translation of CriPec®-based core-crosslinked polymeric micelles. Advanced Drug Delivery Reviews, 191, 1-19. [114613]. https://doi.org/10.1016/j.addr.2022.114613
Timmers, M., Weterings, J., Van Geijn, M., Bell, R., Lenting, P. E., Rijcken, C. J. F., Vermonden, T., Hennink, W. E., & Liskamp, R. M. J. (2022). A New Class of Tunable Acid-Sensitive Linkers for Native Drug Release Based on the Trityl Protecting Group. Bioconjugate Chemistry, 33(9), 1707-1715. https://doi.org/10.1021/acs.bioconjchem.2c00310
Yang, X., Kemmink, J., Rijkers, D. T. S., & Liskamp, R. M. J. (2022). Synthesis of a tricyclic hexapeptide –via two consecutive ruthenium-catalyzed macrocyclization steps– with a constrained topology to mimic vancomycin's binding properties toward D-Ala-D-Ala dipeptide. Bioorganic & Medicinal Chemistry Letters, 73, [128887]. https://doi.org/10.1016/j.bmcl.2022.128887
2019
Scholarly publications
Hoeksma, J., Misset, T., Wever, C., Kemmink, J., Kruijtzer, J., Versluis, K., Liskamp, R. M. J., Boons, G. J., Heck, A. J. R., Boekhout, T., & den Hertog, J. (2019). A new perspective on fungal metabolites: identification of bioactive compounds from fungi using zebrafish embryogenesis as read-out. Scientific Reports, 9(1), [17546]. https://doi.org/10.1038/s41598-019-54127-9
2018
Scholarly publications
Guardiola, S., Prades, R., Mendieta, L., Brouwer, A. J., Streefkerk, J., Nevola, L., Tarragó, T., Liskamp, R. M. J., & Giralt, E. (2018). Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics. Cell Chemical Biology, 25(8), 1031-1037.e4. https://doi.org/10.1016/j.chembiol.2018.04.013
Artschwager, R., Ward, D. J., Gannon, S., Brouwer, A. J., van de Langemheen, H., Kowalski, H., & Liskamp, R. M. J. (2018). Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides. Journal of Medicinal Chemistry, 61(12), 5395-5411. https://doi.org/10.1021/acs.jmedchem.8b00685
2017
Scholarly publications
Yang, X., Beroske, L. P., Kemmink, J., Rijkers, D. T. S., & Liskamp, R. M. J. (2017). Synthesis of bicyclic tripeptides inspired by the ABC-ring system of vancomycin through ruthenium-based cyclization chemistries. Tetrahedron Letters, 58(48), 4542-4546. https://doi.org/10.1016/j.tetlet.2017.10.046
van de Langemheen, H., Korotkovs, V., Bijl, J., Wilson, C., Kale, S. S., Heinis, C., & Liskamp, R. M. J. (2017). Polar Hinges as Functionalized Conformational Constraints in (Bi)cyclic Peptides. ChemBioChem, 18(4), 387-395. https://doi.org/10.1002/cbic.201600612
2016
Scholarly publications
O'Connor, C., Lohan, F., Campos, J., Ohlsson, E., Salomè, M., Forde, C., Artschwager, R., Liskamp, R. M., Cahill, M. R., Kiely, P. A., Porse, B., & Keeshan, K. (2016). The presence of C/EBPα and its degradation are both required for TRIB2-mediated leukaemia. Oncogene, 35(40), 5272-5281. https://doi.org/10.1038/onc.2016.66
Hovestad-Bijl, L., van Ameijde, J., Pijnenburg, D., Hilhorst, R., Liskamp, R., & Ruijtenbeek, R. (2016). Peptide Microarrays for Real-Time Kinetic Profiling of Tyrosine Phosphatase Activity of Recombinant Phosphatases and Phosphatases in Lysates of Cells or Tissue Samples. Methods in Molecular Biology, 1447, 67-78. https://doi.org/10.1007/978-1-4939-3746-2_4
Brouwer, A. J., Herrero Álvarez, N., Ciaffoni, A., van de Langemheen, H., & Liskamp, R. M. J. (2016). Proteasome inhibition by new dual warhead containing peptido vinyl sulfonyl fluorides. Bioorganic and Medicinal Chemistry, 24(16), 3429-3435. https://doi.org/10.1016/j.bmc.2016.05.042
Werkhoven, P. R., Elwakiel, M., Meuleman, T. J., Quarles Van Ufford, H. C., Kruijtzer, J. A. W., & Liskamp, R. M. J. (2016). Molecular construction of HIV-gp120 discontinuous epitope mimics by assembly of cyclic peptides on an orthogonal alkyne functionalized TAC-scaffold. Organic & Biomolecular Chemistry, 14(2), 701-710. https://doi.org/10.1039/c5ob02014j
2015
Scholarly publications
Gilfillan, L., Artschwager, R., Harkiss, A. H., Liskamp, R. M. J., & Sutherland, A. (2015). Synthesis of pyrazole containing α-amino acids via a highly regioselective condensation/aza-Michael reaction of β-aryl α,β-unsaturated ketones. Organic & Biomolecular Chemistry, 13(15), 4514-4523. https://doi.org/10.1039/c5ob00364d
Slootweg, J. C., Van Herwerden, E. F., Van Doremalen, M. F. M., Breukink, E., Liskamp, R. M. J., & Rijkers, D. T. S. (2015). Synthesis of nisin AB dicarba analogs using ring-closing metathesis: Influence of sp<sup>3</sup>versus sp<sup>2</sup> hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity. Organic & Biomolecular Chemistry, 13(21), 5997-6009. https://doi.org/10.1039/c5ob00336a
2014
Scholarly publications
Rijkers, D. T. S., Slootweg, J. C., & Liskamp, R. M. J. (2014). Semi-synthesis of nisin: Tailoring antimicrobial activity and membrane-permeabilizing properties. Journal of Peptide Science, 20, 181-182. https://doi.org/10.1002/psc.2688
Van Ameijde, J., Overvoorde, J., Knapp, S., Den Hertog, J., Ruijtenbeek, R., & Liskamp, R. M. (2014). A new way to interrogate PTPs. Assay and Drug Development Technologies, 12(2), 105-106. https://doi.org/10.1089/adt.2014.1202.lr
Brouwer, A. J., Van De Langemheen, H., & Liskamp, R. M. J. (2014). Expedient synthesis of a novel asymmetric selectively deprotectable derivative of the ATAC scaffold. Tetrahedron, 70(26), 4002-4007. https://doi.org/10.1016/j.tet.2014.04.084
Harmsen, R. A. G., Ghalit, N., Kemmink, J., Breukink, E., Liskamp, R. M. J., & Rijkers, D. T. S. (2014). A conformationally constrained fused tricyclic nisin AB-ring system mimic toward an improved pyrophosphate binder of lipid II. Tetrahedron, 70(42), 7691-7699. https://doi.org/10.1016/j.tet.2014.06.023
Cleophas, R. T. C., Riool, M., Quarles Van Ufford, H. C., Zaat, S. A. J., Kruijtzer, J. A. W., & Liskamp, R. M. J. (2014). Convenient preparation of bactericidal hydrogels by covalent attachment of stabilized antimicrobial peptides using thiol-ene click chemistry. ACS Macro Letters, 3(5), 477-480. https://doi.org/10.1021/mz5001465
Van Der Wal, S., Fu, O., Rontogianni, S., Pieters, R. J., & Liskamp, R. M. J. (2014). Convenient stereoselective synthesis of substituted ureido glycosides using stable 4-chlorophenylcarbamates without the requirement of Lewis acids. Synlett, 25(2), 205-208. [ST-2013-B0885-L]. https://doi.org/10.1055/s-0033-1340220
Van Der Wal, S., Capicciotti, C. J., Rontogianni, S., Ben, R. N., & Liskamp, R. M. J. (2014). Synthesis and evaluation of linear CuAAC-oligomerized antifreeze neo-glycopeptides. MedChemComm, 5(8), 1159-1165. https://doi.org/10.1039/c4md00013g
van Ameijde, J., Zwiebel, A. P. R., Ruijtenbeek, R., & Liskamp, R. M. J. (2014). Azide-alkyne cycloaddition affording enzymatically tunable bisubstrate based inhibitors of histone acetyltransferase PCAF. Bioorganic & Medicinal Chemistry Letters, 24(1), 113-6. https://doi.org/10.1016/j.bmcl.2013.11.060
Brouwer, A. J., van de Langemheen, H., Ciaffoni, A., Schilder, K. E., & Liskamp, R. M. J. (2014). Synthesis of the TACO scaffold as a new selectively deprotectable conformationally restricted triazacyclophane based scaffold. Organic Letters, 16(11), 3106-3109. https://doi.org/10.1021/ol5012218
Liskamp, R. M. J. (2014). Peptides: Bicycling into cells. Nature Chemistry, 6(10), 855-7. https://doi.org/10.1038/nchem.2073
Dubiella, C., Cui, H., Gersch, M., Brouwer, A. J., Sieber, S. A., Krüger, A., Liskamp, R. M. J., & Groll, M. (2014). Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site. Angewandte Chemie-International Edition, 53(44), 11969-11973. https://doi.org/10.1002/anie.201406964
Werkhoven, P. R., van de Langemheen, H., van der Wal, S., Kruijtzer, J. A. W., & Liskamp, R. M. J. (2014). Versatile convergent synthesis of a three peptide loop containing protein mimic of whooping cough pertactin by successive Cu(I)-catalyzed azide alkyne cycloaddition on an orthogonal alkyne functionalized TAC-scaffold. Journal of Peptide Science, 20(4), 235-9. https://doi.org/10.1002/psc.2624
van de Langemheen, H., Quarles van Ufford, H. L. C., Kruijtzer, J. A. W., & Liskamp, R. M. J. (2014). Efficient synthesis of protein mimics by sequential native chemical ligation. Organic Letters, 16(8), 2138-41. https://doi.org/10.1021/ol500604h
van de Langemheen, H., van Hoeke, M., Quarles van Ufford, H. C., Kruijtzer, J. A. W., & Liskamp, R. M. J. (2014). Scaffolded multiple cyclic peptide libraries for protein mimics by native chemical ligation. Organic & Biomolecular Chemistry, 12(25), 4471-4478. https://doi.org/10.1039/c4ob00190g
Cleophas, R. T. C., Sjollema, J., Busscher, H. J., Kruijtzer, J. A. W., & Liskamp, R. M. J. (2014). Characterization and activity of an immobilized antimicrobial peptide containing bactericidal PEG-hydrogel. Biomacromolecules, 15(9), 3390-5. https://doi.org/10.1021/bm500899r
Elgersma, R. C., Kroon - Batenburg, L., Posthuma, G., Meeldijk, J. D., Rijkers, D. T. S., & Liskamp, R. M. J. (2014). PH-controlled aggregation polymorphism of amyloidogenic Aβ (16-22): Insights for obtaining peptide tapes and peptide nanotubes, as function of the N -terminal capping moiety. European Journal of Medicinal Chemistry, 88, 55-65. https://doi.org/10.1016/j.ejmech.2014.07.089
Slootweg, J. C., Peters, N., Quarles Van Ufford, H. C., Breukink, E., Liskamp, R. M. J., & Rijkers, D. T. S. (2014). Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment. Bioorganic & Medicinal Chemistry, 22(19), 5345-5353. https://doi.org/10.1016/j.bmc.2014.07.046
González-Ortiz, G., Quarles Van Ufford, H. C., Halkes, S. B. A., Cerdà-Cuéllar, M., Beukelman, C. J., Pieters, R. J., Liskamp, R. M. J., Pérez, J. F., & Martín-Orue, S. M. (2014). New properties of wheat bran: anti-biofilm activity and interference with bacteria quorum-sensing systems. Environmental Microbiology, 16(5), 1346-1353. https://doi.org/10.1111/1462-2920.12441
González-Ortiz, G., Bronsoms, S., Quarles Van Ufford, H. C., Halkes, S. B. A., Virkola, R., Liskamp, R. M. J., Beukelman, C. J., Pieters, R. J., Pérez, J. F., & Martín-Orúe, S. M. (2014). A proteinaceous fraction of wheat bran may interfere in the attachment of enterotoxigenic E. coli K88 (F4+) to porcine epithelial cells. PLoS One, 9(8), e104258. https://doi.org/10.1371/journal.pone.0104258
Popularising publications
Slootweg, J. C., Van Schaik, T. B., Van Ufford, H. C. Q., Breukink, E., Liskamp, R. M. J., & Rijkers, D. S. (2014). Synthese en toepassing van een lipofiel aminozuurderivaat voor het verbeteren van de membraanaffiniteit van antimicrobiële peptiden. Pharmaceutisch Weekblad, 149(43), 174-179. https://www.scopus.com/record/display.uri?eid=2-s2.0-84949966040&origin=inward&txGid=54b908454fc67400cac49c3a0f33d69c
2013
Scholarly publications
van Wandelen, L. T. M., van Ameijde, J., Ismail-Ali, A. F., Quarles van Ufford, H. C., Vijftigschild, L. A. W., Beekman, J. M., Martin, N. I., Ruijtenbeek, R., & Liskamp, R. M. J. (2013). Cell-penetrating bisubstrate-based protein kinase C inhibitors. ACS Chemical Biology, 8, 1479-1487. https://doi.org/10.1021/cb300709g
2012
Scholarly publications
Mulder, M. P. C., Fodran, P., Kemmink, J., Breukink, E. J., Kruijtzer, J. A. W., Minnaard, A. J., & Liskamp, R. M. J. (2012). Mutual influence of backbone proline substitution and lipophilic tail character on the biological activity of simplified analogues of caspofungin. Organic and Biomolecular Chemistry, 10(37), 7491-7502. https://doi.org/10.1039/c2ob25951f
Brouwer, A. J., Jonker, A., Werkhoven, P., Kuo, E., Li, N., Gallastegui, N., Kemmink, J., Florea, B. I., Groll, M., Overkleeft, H. S., & Liskamp, R. M. J. (2012). Peptido sulfonyl fluorides as new powerful proteasome inhibitors. Journal of Medicinal Chemistry, 55(24), 10995-11003. https://doi.org/10.1021/jm301443r
Shinde, S., Bunschoten, A., Kruijtzer, J. A. W., Liskamp, R. M. J., & Sellergen, B. (2012). Imprinted polymers displaying high affinity for sulfated protein fragments. Angewandte Chemie-International Edition, 51, 8326-8329.
Other output
Zhang, J., Longin, O., Rijkers, D. T. S., & Liskamp, R. M. J. (2012). Cu-(I)- and Ru(II)-catalyzed "click" macrocyclization of tripeptides: toward vancomycin-inspired mimics. 118. Abstract from 32nd European Peptide Symposium.
2011
Scholarly publications
Zhang, J., Kemmink, J., Rijkers, D. T. S., & Liskamp, R. M. J. (2011). Cu(I)- and Ru(II)-mediated "click" cyclization of tripeptides toward vancomycin-inspired mimics. Organic Letters, 13(13), 3438-3441. https://doi.org/10.1021/ol201184b
Yim, C-B., Van Der Wildt, B., Dijkgraaf, I., Joosten, L., Eek, A., Versluis, C., Rijkers, D. T. S., Boerman, O. C., & Liskamp, R. M. J. (2011). Spacer effects on in vivo properties of DOTA-conjugated dimeric [Tyr3]octreotate peptides, synthesized via a 'Cu(I)-Click' and 'sulfo-Click' ligation method. Journal of Labelled Compounds and Radiopharmaceuticals, 54, 217. https://doi.org/10.1002/jlcr.1926
Liskamp, R. M. J., Rijkers, D. T. S., Kruijtzer, J. A. W., & Kemmink, J. (2011). Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics. ChemBioChem, 12, 1626-1653.
2010
Scholarly publications
Slootweg, J. C., Liskamp, R., & Rijkers, D. (2010). Synthesis and structural characterization of all four diastereoisomers of the crossed alkene-bridged nisin DE-ring mimic. Journal of Peptide Science, 16, 45-45. [445]. https://doi.org/10.1002/psc.1302
Parera Pera, N., Branderhorst, H. M., Kooij, R., Maierhofer, C., Van Der Kaaden, M., Liskamp, R. M. J., Wittmann, V., Ruijtenbeek, R., & Pieters, R. J. (2010). Rapid screening of lectins for multivalency effects with a glycodendrimer microarray. ChemBioChem, 11(13), 1896-1904. https://doi.org/10.1002/cbic.201000340
Yim, C-B., Dijkgraaf, I., Merkx, R., Versluis, C., Eek, A., Mulder, G. E., Rijkers, D. T. S., Boerman, O. C., & Liskamp, R. M. J. (2010). Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-Catalyzed Click cycloaddition and thio acid/Sulfonyl azide Sulfo-Click amidation and their in vivo evaluation. Journal of Medicinal Chemistry, 53(10), 3944-3953. https://doi.org/10.1021/jm100246m
Van Ameijde, J., Poot, A. J., Van Wandelen, L. T. M., Wammes, A. E. M., Ruijtenbeek, R., Rijkers, D. T. S., & Liskamp, R. M. J. (2010). Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors. Organic and Biomolecular Chemistry, 8(7), 1629-1639. https://doi.org/10.1039/b922928k
Bunschoten, A., Feitsma, L. J., Kruijtzer, J. A., de Haas, C. J. C., Liskamp, R. M. J., & Kemmink, J. (2010). CHIPS binds to the phosphorylated N-terminus of the C5a-receptor. Bioorganic & Medicinal Chemistry Letters, 20(11), 3338-3340. http://www.ncbi.nlm.nih.gov/pubmed/20457523
Other output
Liskamp, R. M. J., Yim, C. B., Merkx, N. S. M., Elgersma, R. C., van Dijk, M., Brouwer, A. J., Boerman, O., van Nostrum, C. F., Hennink, W. E., Pieters, R. J., Kruijtzer, J. A. W., & Rijkers, D. T. S. (2010). Click chemistry in the synthesis of large peptide molecular constructs and peptide-based polymers. 27-28. Abstract from Unknown event.
Kruijtzer, J. A. W., Bunschoten, A., & Liskamp, R. M. J. (2010). A critical comparison of sequence independent solid phase methods for the site-specific synthesis of multiple sulfated peptides. 64. Abstract from Unknown event.
2009
Scholarly publications
Nuijens, T., Cusan, C., Kruijtzer, J. A. W., Rijkers, D. T. S., Liskamp, R. M. J., & Quaedflieg, P. J. L. M. (2009). Versatile selective α-carboxylic acid esterification of N-protected amino acids and peptides by alcalase. Synthesis, (5), 809-814. https://doi.org/10.1055/s-0028-1083362
Nuijens, T., Kruijtzer, J. A. W., Cusan, C., Rijkers, D. T. S., Liskamp, R. M. J., & Quaedflieg, P. J. L. M. (2009). A versatile and selective chemo-enzymatic synthesis of β-protected aspartic and γ-protected glutamic acid derivatives. Tetrahedron Letters, 50(23), 2719-2721. https://doi.org/10.1016/j.tetlet.2009.03.130
Elgersma, R. C., Rijkers, D. T. S., & Liskamp, R. M. J. (2009). pH controlled aggregation morphology of Abeta(16-22): formation of peptide nanotubes, helical tapes and amyloid fibrils. Advances in Experimental Medicine and Biology, 611, 239-240. https://doi.org/10.1007/978-0-387-73657-0_109
Elgersma, R. C., Van Dijk, M., Dechesne, A. C., Van Nostrum, C. F., Hennink, W. E., Rijkers, D. T. S., & Liskamp, R. M. J. (2009). Microwave-assisted click polymerization for the synthesis of Aβ(16-22) cyclic oligomers and their self-assembly into polymorphous aggregates. Organic and Biomolecular Chemistry, 7(21), 4517-4525. https://doi.org/10.1039/b912851d
Kuil, J., Branderhorst, H. M., Pieters, R. J., de Mol, N. J., & Liskamp, R. M. J. (2009). ITAM-derived phosphopeptide-containing dendrimers as multivalent ligands for Syk tandem SH2 domain. Organic & Biomolecular Chemistry, 7, 4088-4094.
van Scherpenzeel, M., Moret, E. E., Ballell, L., Liskamp, R. M. J., Nilsson, U. J., Leffler, H., & Pieters, R. J. (2009). Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. ChemBioChem, 10, 1724-1733.
Brouwer, A. J., Ceylan, T., van der Linden, T., & Liskamp, R. M. J. (2009). Synthesis of beta-aminoethanesulfonyl fluorides or 2-substituted taurine sulfonyl fluorides as potential protease inhibitors. Tetrahedron Letters, 50, 3391-3393.
2008
Scholarly publications
Brouwer, A. J., Elgersma, R. C., Jagodzinska, M., Rijkers, D. T. S., & Liskamp, R. M. J. (2008). Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis. Bioorganic and Medicinal Chemistry Letters, 18(1), 78-84. https://doi.org/10.1016/j.bmcl.2007.11.009
2007
Scholarly publications
Pukin, A. V., Branderhorst, H. M., Sisu, C., Weijers, C. A. G. M., Gilbert, M., Liskamp, R. M. J., Visser, G. M., Zuilhof, H., & Pieters, R. J. (2007). Strong inhibition of cholera toxin by multivalent GM1 derivatives. ChemBioChem, 8(13), 1500-1503. https://doi.org/10.1002/cbic.200700266
Arnusch, C. J., Branderhorst, H., De Kruijff, B., Liskamp, R. M. J., Breukink, E., & Pieters, R. J. (2007). Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Biochemistry, 46(46), 13437-13442. https://doi.org/10.1021/bi7015553
Branderhorst, H. M., Liskamp, R. M. J., Visser, G. M., & Pieters, R. J. (2007). Strong inhibition of cholera toxin binding by galactose dendrimers. Chemical Communications, 5043-5045.
Other output
Pieters, R. J., Pukin, A. V., Aliaksei, V., Branderhorst, H. M., Weijers, C. A. G. M., Gilbert, M., Liskamp, R. M. J., Visser, G. M., & Zuilhof, H. (2007). Strong inhibition of cholera toxin by multivalent GM1 derivatives. Abstract from 234th ACS National Meeting.
2006
Scholarly publications
Brouwer, A. J., Merkx, R., Dabrowska, K., Rijkers, D. T. S., & Liskamp, R. M. J. (2006). Synthesis and applications of β-aminoethanesulfonyl azides. Synthesis, (3), 455-460. https://doi.org/10.1055/s-2006-926273
Elgersma, R. C., Meijneke, T., De Jong, R., Brouwer, A. J., Posthuma, G., Rijkers, D. T. S., & Liskamp, R. M. J. (2006). Synthesis and structural investigations of N-alkylated β-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials. Organic and Biomolecular Chemistry, 4(19), 3587-3597. https://doi.org/10.1039/b606875h
Elgersma, R. C., Meijneke, T., Posthuma, G., Rijkers, D. T. S., & Liskamp, R. M. J. (2006). Self-assembly of amylin(20-29) amide-bond derivatives into helical ribbons and peptide nanotubes rather than fibrils. Chemistry - A European Journal, 12(14), 3714-3725. https://doi.org/10.1002/chem.200501374
2005
Scholarly publications
Joosten, J. A. F., Tholen, N. T. H., Ait El Maate, F., Brouwer, A. J., Wilma Van Esse, G., Rijkers, D. T. S., Liskamp, R. M. J., & Pieters, R. J. (2005). High-yielding microwave-assisted synthesis of triazole-linked glycodendrimers by copper-catalyzed [3+2] cycloaddition. European Journal of Organic Chemistry, (15), 3182-3185. https://doi.org/10.1002/ejoc.200500216
Merkx, R., Brouwer, A. J., Rijkers, D. T. S., & Liskamp, R. M. J. (2005). Highly efficient coupling of β-substituted aminoethane sulfonyl azides with thio acids, toward a new chemical ligation reaction. Organic Letters, 7(6), 1125-1128. https://doi.org/10.1021/ol0501119
Haan, E., Wagenaar-Hilbers, J. P. A., Liskamp, R. M. J., Moret, E. E., & Wauben, M. H. M. (2005). Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides. Molecular Immunology, 42(3), 355-364.
Wels, B., Kruijtzer, J. A. W., Garner, K. M., Adan, R. A. H., & Liskamp, R. M. J. (2005). Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups. Bioorganic & Medicinal Chemistry Letters, 15, 287-290.
Broekema, M., van Eerd, J. J. E. M., Oyen, W. J. G., Corstens, F. H. M., Liskamp, R. M. J., Boerman, O. C., & Harris, T. D. (2005). Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc99m to image infectious ad inflammatory foci. Journal of Medicinal Chemistry, 48, 6442-6453.
Haan, E., Moret, E. E., Wagenaar-Hilbers, J. P. A., Liskamp, R. M. J., & Wauben, M. H. M. (2005). Possibilities and limitations in the rational design of modified peptides for T cell mediated immunotherapy. Molecular Immunology, 42(3), 365-373.
2004
Scholarly publications
Wang, X., Permentier, HP., Rink, R., Kruijtzer, JAW., Liskamp, RMJ., Wosten, HAB., Poolman, B., & Robillard, GT. (2004). Probing the self-assembly and the accompanying structural changes of hydrophobin SC3 on a hydrophobic surface by mass spectrometry. Biophysical Journal, 87(3), 1919-1928. https://doi.org/10.1529/biophysj.104.041616
Arosio, D., Vrasidas, I., Valentini, P., Liskamp, R. M. J., Pieters, R. J., & Bernardi, A. (2004). Synthesis and cholera toxin binding properties of multivalent GM1 mimics. Organic & Biomolecular Chemistry, 2(14), 2113-2124. https://doi.org/10.1039/B405344C
De Planque, M. R. R., Rijkers, D. T. S., Fletcher, J. I., Liskamp, R. M. J., & Separovic, F. (2004). The αm1 segment of the nicotinic acetylcholine receptor exhibits conformational flexibility in a membrane environment. Biochimica et Biophysica Acta - Biomembranes, 1665(1-2), 40-47. https://doi.org/10.1016/j.bbamem.2004.06.021
De Planque, M. R. R., Rijkers, D. T. S., Liskamp, R. M. J., & Separovic, F. (2004). The αM1 transmembrane segment of the nicotinic acetylcholine receptor interacts strongly with model membranes. Magnetic Resonance in Chemistry, 42(2), 148-154. https://doi.org/10.1002/mrc.1326
Strandberg, E. J., Özdirekcan, S., Rijkers, D. T. S., van der Wel, P. C. A., Koeppe II, R. E., Liskamp, R. M. J., & Killian, J. A. (2004). Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H Solid State NMR. Biophysical Journal, 86, 3709-3721.
https://dspace.library.uu.nl/bitstream/handle/1874/14623/Strandberg-Tilt%2520angles.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/14623/Strandberg-Tilt%2520angles.pdf?sequence=1
2003
Scholarly publications
Dekker, F. J., de Mol, N. J., Fischer, M. J. E., & Liskamp, R. M. J. (2003). Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand. Bioorganic & Medicinal Chemistry Letters, 13, 1241-1244.
Nijenhuis, W. A. J., Kruijtzer, J. A. W., Wanders, N., Vrinten, D. H., Garner, K. M., Schaaper, W. M. M., Meloen, R. H., Gispen, W. H., Liskamp, R. M. J., & Adan, R. A. H. (2003). Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides. Peptides, 24, 271-280.
2002
Scholarly publications
De Jong, R., Rijkers, D. T. S., & Liskamp, R. M. J. (2002). Automated solid-phase synthesis and structural investigation of β-peptidosulfonamides and β-peptidosulfonamide/β-peptide hybrids: β-peptidosulfonamide and β-peptide foldamers are two of a different kind. Helvetica Chimica Acta, 85(12), 4230-4243. https://doi.org/10.1002/hlca.200290008
De Planque, M. R. R., Boots, J. W. P., Rijkers, D. T. S., Liskamp, R. M. J., Greathouse, D. V., & Killian, J. A. (2002). The effects of hydrophobic mismatch between phosphatidylcholine bilayers and transmembrane α-helical peptides depend on the nature of interfacially exposed aromatic and charged residues. Biochemistry, 41(26), 8396-8404. https://doi.org/10.1021/bi0257686
Rijkers, D. T. S., Höppener, J. W. M., Posthuma, G., Lips, C. J. M., & Liskamp, R. M. J. (2002). Inhibition of amyloid fibril formation of human amylin by N-alkylated amino acid and α-hydroxy acid residue containing peptides. Chemistry - A European Journal, 8(18), 4285-4291. https://doi.org/10.1002/1521-3765(20020916)8:18<4285::AID-CHEM4285>3.0.CO;2-0
Rump, E. T., Rijkers, D. T. S., Hilbers, H. W., De Groot, P. G., & Liskamp, R. M. J. (2002). Cyclotriveratrylene (CTV) as a new chiral triacid scaffold capable of inducing triple helix formation of collagen peptides containing either a native sequence or Pro-Hyp-Gly repeats. Chemistry - A European Journal, 8(20), 4613-4621. https://doi.org/10.1002/1521-3765(20021018)8:20<4613::AID-CHEM4613>3.0.CO;2-R
Vrasidas, I., Kemmink, J., Liskamp, R. M. J., & Pieters, R. J. (2002). Synthesis and cholera toxin binding properties of a lactose-2-aminothiazoline conjugate. Organic Letters, 4, 1807-1808.
2001
Scholarly publications
de Planque, M. R. R., Goormaghtigh, E., Greathouse, D. V., Koeppe, R. E., Kruijtzer, J. A. W., Liskamp, R. M. J., de Kruijff, B., & Killian, J. A. (2001). Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry, 40, 5000-5010.
2000
Scholarly publications
Reichwein, J. F., & Liskamp, R. M. J. (2000). Synthesis of cyclic dipeptides by Ring-Closing Metathesis. European Journal of Organic Chemistry, 2335-2344.
1999
Scholarly publications
van Dijk-Wolthuis, W. N. E., van de Wetering, P., Hinrichs, W. L. J., Hofmeyer, L. J. F., Liskamp, R. M. J., Crommelin, D. J. A., & Hennink, W. E. (1999). A versatile method for the conjugation of proteins and peptides to poly[2-(dimethylamino)ethyl methacrylate]. Bioconjugate Chemistry, 10(4), 687-692. https://doi.org/10.1021/bc980126+
Other output
Vrasidas, I., Pieters, R. J., & Liskamp, R. M. J. (1999). Carbohydrate dendrimers as multivalent anti-adhesion ligands. Abstract from 1st International dendrimer symposium, Frankfurt/Main, Germany.
Ruytenbeek, R., van der Wiel, W., Kruijtzer, J. A. W., Redegeld, F. A. M., Nijkamp, F. P., & Liskamp, R. M. J. (1999). Solid phase synthesis of a set on peptide-peptoid hybrids to investigate the effect of side chain position on syk SH2 domain binding. Abstract from 16th American peptide symposium, Minneapolis, Minnesota, U.S.A..
Liskamp, R. M. J. (1999). Scaffolds and building blocks for combinatorial libraries of synthetic receptors and catalysts. Abstract from International combinatorial chemistry symposium, Tubingen.
1998
Scholarly publications
Löwik, D. W. P. M., Weingarten, M. D., Broekema, M., Brouwer, A. J., Still, W. C., & Liskamp, R. M. J. (1998). Tweezers with different bite: increasing the affinity of synthetic receptors by varying the hinge part. Angewandte Chemie-International Edition, 37, 1846-1850.
Kruijtzer, J. A. W., Hofmeyer, L. J. F., Heerma, W., Versluis, C., & Liskamp, R. M. J. (1998). Solid-phase syntheses of peptoid using Fmoc-protected N-substituted glycines: the synthesis of (retro)peptoids of leu-enkephalin and substance P. Chemistry-A European Journal, 4(8), 1570-1580. https://doi.org/10.1002/(SICI)1521-3765(19980807)4:8<1570::AID-CHEM1570>3.0.CO;2-2
Other output
Quaedflieg, P. J. L. M., Broxterman, Q. B., van Leeuwen, S. H., & Liskamp, R. M. J. (1998). Process for the preparation of amino acid amides of derivatives thereof. (Patent No. 1010867).
1997
Scholarly publications
Moret, E. E., Liskamp, R. M. J., & Tollenaere, J. P. (1997). Structure-based design of epitope mimetics. In Pharmacochemistry Library: Proceedings XIVth International Symposium on Medicinal Chemistry (C ed., Vol. 28, pp. 371-381). (Pharmacochemistry Library). https://doi.org/10.1016/S0165-7208(97)80079-7