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Prof. dr. P. (Piet) Gros

Professor 
Science
Chemistry
Biomolecular Sciences
Structural Biochemistry
Structural Biochemistry
David de Wiedgebouw
Universiteitsweg 99
Kamer 2.72
3584 CG Utrecht

Prof. dr. P. (Piet) Gros

Professor
Structural Biochemistry
+31 30 253 3127
p.gros@uu.nl
Profile CV Publications Activities Prizes Research Teaching Ancillary activities Contact
Profile CV Publications Activities Prizes Research Teaching Ancillary activities Contact
Areas of expertise
Research areas

Publications

2022

Scholarly publications

El Mazouni, D., & Gros, P. (2022). Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis. Science advances, 8(45), eadd3677. https://doi.org/10.1126/sciadv.add3677
De la O Becerra, K. I., Oosterheert, W., van den Bos, R. M., Xenaki, K. T., Lorent, J. H., Ruyken, M., Schouten, A., Rooijakkers, S. H. M., van Bergen en Henegouwen, P. M. P., & Gros, P. (2022). Multifaceted Activities of Seven Nanobodies against Complement C4b. Journal of Immunology, 208(9), 2207-2219. https://doi.org/10.4049/jimmunol.2100647
Geisbrecht, B. V., Lambris, J. D., & Gros, P. (2022). Complement component C3: A structural perspective and potential therapeutic implications. Seminars in Immunology, 59, [101627]. https://doi.org/10.1016/j.smim.2022.101627
Lamers, C., Xue, X., Smieško, M., van Son, H., Wagner, B., Berger, N., Sfyroera, G., Gros, P., Lambris, J. D., & Ricklin, D. (2022). Insight into mode-of-action and structural determinants of the compstatin family of clinical complement inhibitors. Nature Communications, 13(1), [5519]. https://doi.org/10.1038/s41467-022-33003-7
Neviani, V., Lutz, M., Oosterheert, W., Gros, P., & Kroon-Batenburg, L. (2022). Crystal structure of the second extracellular domain of human tetraspanin CD9: twinning and diffuse scattering. IUCrData, 7(9). https://doi.org/10.1107/S2414314622008525

2021

Scholarly publications

Geuijen, C. A. W., De Nardis, C., Maussang, D., Rovers, E., Gallenne, T., Hendriks, L. J. A., Visser, T., Nijhuis, R., Logtenberg, T., de Kruif, J., Gros, P., & Throsby, M. (2021). Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade. Cancer Cell, 39(8), 1163-1164. https://doi.org/10.1016/j.ccell.2021.07.015
Pearce, N. M., & Gros, P. (2021). A method for intuitively extracting macromolecular dynamics from structural disorder. Nature Communications, 12(1), 1-11. [5493]. https://doi.org/10.1038/s41467-021-25814-x
Ploscariu, N., Burnley, T., Gros, P., & Pearce, N. M. (2021). Improving sampling of crystallographic disorder in ensemble refinement. Acta Crystallographica Section D: Structural Biology, 77(11), 1357-1364. [D77]. https://doi.org/10.1107/S2059798321010044
Zwarthoff, S. A., Widmer, K., Kuipers, A., Strasser, J., Ruyken, M., Aerts, P. C., Haas, C. J. C. D., Ugurlar, D., Boer, M. A. D., Vidarsson, G., Strijp, J. A. G. V., Gros, P., Parren, P. W. H. I., Kessel, K. P. M. V., Preiner, J., Beurskens, F. J., Schuurman, J., Ricklin, D., & Rooijakkers, S. H. M. (2021). C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases. Proceedings of the National Academy of Sciences, 118(26), 1-12. [e2102787118]. https://doi.org/10.1073/pnas.2102787118

2020

Scholarly publications

Oosterheert, W., Reis, J., Gros, P., & Mattevi, A. (2020). An Elegant Four-Helical Fold in NOX and STEAP Enzymes Facilitates Electron Transport across Biomembranes-Similar Vehicle, Different Destination. Accounts of Chemical Research, 53(9), 1969-1980. https://doi.org/10.1021/acs.accounts.0c00400
Neviani, V., van Deventer, S., Wörner, T. P., Xenaki, K. T., van de Waterbeemd, M., Rodenburg, R. N. P., Wortel, I. M. N., Kuiper, J. K., Huisman, S., Granneman, J., van Bergen En Henegouwen, P. M. P., Heck, A. J. R., van Spriel, A. B., & Gros, P. (2020). Site-specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9. The FEBS journal, 287(24), 5323-5344. https://doi.org/10.1111/febs.15295
Wang, G., Chaihu, L., Tian, M., Shao, X., Dai, R., de Jong, R. N., Ugurlar, D., Gros, P., & Heck, A. J. R. (2020). Releasing Nonperipheral Subunits from Protein Complexes in the Gas Phase. Analytical Chemistry, 92(24), 15799–15805. https://doi.org/10.1021/acs.analchem.0c02845
Oosterheert, W., & Gros, P. (2020). Cryo-electron microscopy structure and potential enzymatic function of human six-transmembrane epithelial antigen of the prostate 1 (STEAP1). Journal of Biological Chemistry, 295(28), 9502-9512. https://doi.org/10.1074/jbc.RA120.013690
Oosterheert, W., Xenaki, K. T., Neviani, V., Pos, W., Doulkeridou, S., Manshande, J., Pearce, N. M., Kroon-batenburg, L. M., Lutz, M., Van Bergen En Henegouwen, P. M., & Gros, P. (2020). Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F. Life Science Alliance, 3(11), [e202000883]. https://doi.org/10.26508/lsa.202000883

2019

Scholarly publications

Fenderico, N., van Scherpenzeel, R. C., Goldflam, M., Proverbio, D., Jordens, I., Kralj, T., Stryeck, S., Bass, T. Z., Hermans, G., Ullman, C., Aastrup, T., Gros, P., & Maurice, M. M. (2019). Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells. Nature Communications, 10(1), [365]. https://doi.org/10.1038/s41467-018-08172-z
Mastellos, D. C., Blom, A. M., Connolly, E. S., Daha, M. R., Geisbrecht, B. V., Ghebrehiwet, B., Gros, P., Hajishengallis, G., Holers, V. M., Huber-Lang, M., Kinoshita, T., Mollnes, T. E., Montgomery, R. A., Morgan, B. P., Nilsson, B., Pio, R., Ricklin, D., Risitano, A. M., Taylor, R. P., ... Lambris, J. D. (2019). 'Stealth' corporate innovation: an emerging threat for therapeutic drug development. Nature Immunology, 20(11), 1409-1413. https://doi.org/10.1038/s41590-019-0503-1
van den Bos, R. M., Pearce, N. M., Granneman, J., Brondijk, T. H. C., & Gros, P. (2019). Insights Into Enhanced Complement Activation by Structures of Properdin and Its Complex With the C-Terminal Domain of C3b. Frontiers in Immunology, 10, 2097. https://doi.org/10.3389/fimmu.2019.02097
Sharp, T. H., Boyle, A. L., Diebolder, C. A., Kros, A., Koster, A. J., & Gros, P. (2019). Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b. Proceedings of the National Academy of Sciences of the United States of America, 116(24), 11900-11905. https://doi.org/10.1073/pnas.1901841116
Mastellos, D. C., Blom, A. M., Connolly, E. S., Daha, M. R., Geisbrecht, B. V., Ghebrehiwet, B., Gros, P., Hajishengallis, G., Holers, V. M., Huber-Lang, M., Kinoshita, T., Mollnes, T. E., Montgomery, R. A., Morgan, B. P., Nilsson, B., Pio, R., Ricklin, D., Risitano, A. M., Taylor, R. P., ... Lambris, J. D. (2019). Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development. Nature Immunology, 20(11), 1556. https://doi.org/10.1038/s41590-019-0531-x

2018

Scholarly publications

On Behalf of the COMBAT Consortium, & Gros, P. (2018). Overactivity of alternative pathway convertases in patients with complement-mediated renal diseases. Frontiers in Immunology, 9(APR), [612]. https://doi.org/10.3389/fimmu.2018.00612
Oosterheert, W., van Bezouwen, L. S., Rodenburg, R. N. P., Granneman, J., Förster, F., Mattevi, A., & Gros, P. (2018). Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction. Nature Communications, 9(1), [4337]. https://doi.org/10.1038/s41467-018-06817-7
Mohlin, F. C., Gros, P., Mercier, E., Gris, J-C. R., & Blom, A. M. (2018). Analysis of C3 Gene Variants in Patients With Idiopathic Recurrent Spontaneous Pregnancy Loss. Frontiers in Immunology, 9, [1813]. https://doi.org/10.3389/fimmu.2018.01813
Geuijen, C. A. W., De Nardis, C., Maussang, D., Rovers, E., Gallenne, T., Hendriks, L. J. A., Visser, T., Nijhuis, R., Logtenberg, T., de Kruif, J., Gros, P., & Throsby, M. (2018). Unbiased Combinatorial Screening Identifies a Bispecific IgG1 that Potently Inhibits HER3 Signaling via HER2-Guided Ligand Blockade. Cancer Cell, 33(5), 922-936.e10. https://doi.org/10.1016/j.ccell.2018.04.003
Ugurlar, D., Howes, S. C., de Kreuk, B-J., Koning, R. I., de Jong, R. N., Beurskens, F. J., Schuurman, J., Koster, A. J., Sharp, T. H., Parren, P. W. H. I., & Gros, P. (2018). Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement. Science, 359(6377), 794-797. https://doi.org/10.1126/science.aao4988

2017

Scholarly publications

Sharp, T. H., Faas, F. G. A., Koster, A. J., & Gros, P. (2017). Imaging complement by phase-plate cryo-electron tomography from initiation to pore formation. Journal of Structural Biology, 197(2), 155-162. https://doi.org/10.1016/j.jsb.2016.09.008
De Nardis, C., Hendriks, L. J. A., Poirier, E., Arvinte, T., Gros, P., Bakker, A. B. H., & de Kruif, J. (2017). A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1. Journal of Biological Chemistry, 292(35), 14706-14717. https://doi.org/10.1074/jbc.M117.793497
Xue, X., Wu, J., Ricklin, D., Forneris, F., Di Crescenzio, P., Schmidt, C. Q., Granneman, J., Sharp, T. H., Lambris, J. D., & Gros, P. (2017). Regulator-dependent mechanisms of C3b processing by factor i allow differentiation of immune responses. Nature Structural and Molecular Biology, 24(8), 643-651. https://doi.org/10.1038/nsmb.3427
Rodenburg, R. N. P., Snijder, J., van de Waterbeemd, M., Schouten, A., Granneman, J., Heck, A. J. R., & Gros, P. (2017). Stochastic palmitoylation of accessible cysteines in membrane proteins revealed by native mass spectrometry. Nature Communications, 8(1), [1280]. https://doi.org/10.1038/s41467-017-01461-z
De Nardis, C., Lössl, P., Van Den Biggelaar, M., Madoori, P. K., Leloup, N., Mertens, K., Heck, A. J. R., & Gros, P. (2017). Recombinant expression of the full-length ectodomain of LDL receptor-related protein 1 (LRP1) unravels phdependent conformational changes and the stoichiometry of binding with receptor-associated protein (RAP). Journal of Biological Chemistry, 292(3), 912-924. https://doi.org/10.1074/jbc.M116.758862

2016

Scholarly publications

Xue, X., Wu, J., Forneris, F., Ricklin, D., Di Crescenzio, P., Schmidt, C. Q., Granneman, J., Lambris, J. D., & Gros, P. (2016). Structural insights into cofactor activity. Immunobiology, 221(10), 1193. https://doi.org/10.1016/j.imbio.2016.06.152
Sharp, T. H., Koster, A. J., & Gros, P. (2016). Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography. Cell Reports, 15(1), 1-8. https://doi.org/10.1016/j.celrep.2016.03.002
Forneris, F., Wu, J., Xue, X., Ricklin, D., Lin, Z., Sfyroera, G., Tzekou, A., Volokhina, E., Granneman, J. C. M., Hauhart, R., Bertram, P., Liszewski, M. K., Atkinson, J. P., Lambris, J. D., & Gros, P. (2016). Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode. EMBO Journal, 35(10), 1133-1149. https://doi.org/10.15252/embj.201593673
Sharp, T. H., Koster, A. J., & Gros, P. (2016). Imaging complement activation step-by-step on liposomes by phase-plate cryo-electron tomography. Immunobiology, 221(10), 1194-1195. https://doi.org/10.1016/j.imbio.2016.06.155
Ricklin, D., Reis, E. S., Mastellos, D. C., Gros, P., & Lambris, J. D. (2016). Complement component C3 – The “Swiss Army Knife” of innate immunity and host defense. Immunological Reviews, 274(1), 33-58. https://doi.org/10.1111/imr.12500
Wang, G., de Jong, R. N., van den Bremer, E. T. J., Beurskens, F. J., Labrijn, A. F., Ugurlar, D., Gros, P., Schuurman, J., Parren, P. W. H. I., & Heck, A. J. R. (2016). Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen. Molecular Cell, 63, 135-145. https://doi.org/10.1016/j.molcel.2016.05.016

2015

Scholarly publications

Berends, E. T. M., Gorham, R. D., Ruyken, M., Soppe, J. A., Orhan, H., Aerts, P. C., de Haas, C. J. C., Gros, P., & Rooijakkers, S. H. M. (2015). Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes. BMC Biology, 13, 93. https://doi.org/10.1186/s12915-015-0203-8
Kroon-Batenburg, L. M. J., Schreurs, A. M. M., Ravelli, R. G., & Gros, P. (2015). Accounting for partiality in serial crystallography using ray-tracing principles. Acta crystallographica. Section D, biological crystallography, 71(9), 1799-1811. https://doi.org/10.1107/S1399004715011803
Vissers, L. ELM., Bonetti, M., Paardekooper Overman, J., Nillesen, W. M., Frints, S. G. M., de Ligt, J., Zampino, G., Justino, A., Machado, J. C., Schepens, M., Brunner, H. G., Veltman, J. A., Scheffer, H., Gros, P., Costa, J. L., Tartaglia, M., van der Burgt, I., Yntema, H. G., & den Hertog, J. (2015). Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome. European Journal of Human Genetics. https://doi.org/10.1038/ejhg.2014.115

2014

Scholarly publications

de Lau, W., Peng, W. C., Gros, P., & Clevers, H. (2014). The R-spondin/Lgr5/Rnf43 module: Regulator of Wnt signal strength. Genes and Development, 28(4), 305-316. https://doi.org/10.1101/gad.235473.113
Forneris, F., Burnley, B. T., & Gros, P. (2014). Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D. Acta crystallographica. Section D, biological crystallography, 70(3), 733-743. https://doi.org/10.1107/S1399004713032549
Diebolder, C. A., Beurskens, F. J., De Jong, R. N., Koning, R. I., Strumane, K., Lindorfer, M. A., Voorhorst, M., Ugurlar, D., Rosati, S., Heck, A. J. R., Van De Winkel, J. G. J., Wilson, I. A., Koster, A. J., Taylor, R. P., Saphire, E. O., Burton, D. R., Schuurman, J., Gros, P., & Parren, P. W. H. I. (2014). Complement is activated by IgG hexamers assembled at the cell surface. Science, 343(6176), 1260-1263. https://doi.org/10.1126/science.1248943

2013

Scholarly publications

Forneris, F., & Gros, P. (2013). Complement Factor D. In Handbook of Proteolytic Enzymes (Vol. 3, pp. 2841-2848). Elsevier. https://doi.org/10.1016/B978-0-12-382219-2.00630-X
Gros, P., & Forneris, F. (2013). Proteolysis, complex formation and conformational changes drive the complement pathways. In R. Randy, A. Urzhumtsev, U. Alexandre, & V. Lunin (Eds.), Advancing Methods for Biomolecular Crystallography (pp. 297-307). (NATO Science for Peace and Security Series A: Chemistry and Biology). https://doi.org/10.1007/978-94-007-6232-9-25
Burnley, B. T., & Gros, P. (2013). phenix.ensemble_refinement: a test study of apo and holo BACE1. Computational crystallography newsletter, 4, 51-58.
https://dspace.library.uu.nl/bitstream/handle/1874/290786/07.pdf?sequence=1
Peng, W. C., de Lau, W., Forneris, F., Granneman, J. C. M., Clevers, H. C., & Gros, P. (2013). Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5. Cell Reports [E], 3(6), 1885-1892. https://doi.org/10.1016/j.celrep.2013.06.009
Peng, W. C., de Lau, W., Madoori, P. K., Forneris, F., Granneman, J. C. M., Clevers, H., & Gros, P. (2013). Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling. PLoS One, 8(12), e83110. [e83110]. https://doi.org/10.1371/journal.pone.0083110

2012

Scholarly publications

Volokhina, E. B., Westra, D., Xue, X., Gros, P., van der Kar, N. C. A. J., & van den Heuvel, L. (2012). Novel C3 mutation p.Lys65Gln in aHUS affects complement factor H binding. Pediatric Nephrology, 27, 1519-1524. https://doi.org/10.1007/s00467-012-2183-z
Forneris, F., Wu, J., & Gros, P. (2012). The modular serine proteases of the complement cascade. Current Opinion in Structural Biology, 22(3), 333-341. https://doi.org/10.1016/j.sbi.2012.04.001
Burnley, B. T., Afonine, P. V., Adams, P. D., & Gros, P. (2012). Modelling dynamics in protein crystal structures by ensemble refinement. eLife, 1, 1-29. [00311]. https://doi.org/10.7554/eLife.00311.001
van Galen, J., Olrichs, N. K., Schouten, A., Serrano, R. L., Nolte-'t Hoen, E. N. M., Eerland, R., Kaloyanova, D., Gros, P., & Helms, J. B. (2012). Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization. Biochimica et Biophysica Acta, 1818(9), 2175-2183. https://doi.org/10.1016/j.bbamem.2012.04.016
Hadders, M. A., Bubeck, D., Roversi, P., Hakobyan, S., Forneris, F., Morgan, B. P., Pangburn, M. K., Llorca, O., Lea, S. M., & Gros, P. (2012). Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. Cell Reports [E], 1(3), 200-207. https://doi.org/10.1016/j.celrep.2012.02.003

2011

Scholarly publications

Gros, P. (2011). In self-defense. Nature Structural and Molecular Biology, 18(4), 401-402. https://doi.org/10.1038/nsmb.2036
Roussel-Jazédé, V. M. C., van Gelder, P., Sijbrandi, R., Rutten, L., Otto, B. R., Luirink, J., Gros, P., Tommassen, J. P. M., & van Ulsen, J. P. (2011). Channel properties of the translocator domain of the autotransporter Hbp of Escherichia coli. Molecular Membrane Biology, 28(3), 158-170. https://doi.org/10.3109/09687688.2010.550328

2010

Scholarly publications

Serruto, D., Rappuoli, R., Scarselli, M., Gros, P., & van Strijp, J. A. G. (2010). Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nature Reviews. Microbiology, 8, 393-399.
Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R. S., Lambris, J. D., & Gros, P. (2010). Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science, 330(6012), 1816-1820. https://doi.org/10.1126/science.1195821

2009

Scholarly publications

Fritzinger, D. C., Hew, B. E., Thorne, M., Pangburn, M. K., Gros, P., Janssen, B. J. C., & Vogel, C. W. (2009). Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion. Developmental and Comparative Immunology, 33(1), 105-116. https://doi.org/10.1016/j.dci.2008.07.006
Janssen, B. J. C., Gomes, L., Koning, R. I., Svergun, D. I., Koster, A. J., Fritzinger, D. C., Vogel, C. W., & Gros, P. (2009). Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. EMBO Journal, 28(16), 2469-2478. https://doi.org/10.1038/emboj.2009.184
Wu, J., Wu, Y., Ricklin, D., Janssen, B. J. C., Lambris, J. D., & Gros, P. (2009). Structure of complement fragment C3b–factor H and implications for host protection by complement regulators. Nature Immunology, 10(7), 728-733. https://doi.org/10.1038/ni.1755
Rutten, L., Wieczorek, B., Mannie, J-PBA., Kruithof, C. A., Dijkstra, H. P., Egmond, M. R., Lutz, M., Klein Gebbink, R. J. M., Gros, P., & van Koten, G. (2009). Solid-state structural characterization of cutinase-ECE-pincer-metal hybrids. Chemistry-A European Journal, 15(17), 4270-4280.
Rooijakkers, S. H. M., Wu, J., Ruyken, M., van Domselaar, R., Planken, K. L., Tzekou, A., Ricklin, D., Lambris, J. D., Janssen, B. J., van Strijp, J. A. G., & Gros, P. (2009). Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nature Immunology, 10(7), 721-727. http://www.ncbi.nlm.nih.gov/pubmed/19503103
Rutten, L., Mannie, J-PBA., Stead, C. M., Raetz, C. R. H., Reynolds, C. M., Bonvin, A. M. J. J., Tommassen, J. P. M., Egmond, M. R., Trent, M. S., & Gros, P. (2009). Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium. Proceedings of the National Academy of Sciences of the United States of America, 106(6), 1960-1964. https://doi.org/10.1073/pnas.0813064106
https://dspace.library.uu.nl/bitstream/handle/1874/42725/1960.full.pdf?sequence=1
Poodt, P. W. G., Heijna, M. C. R., Schouten, A., Gros, P., van Enckevort, W. J. P., & Vlieg, E. (2009). Simple geometry for diffusion limited protein crystal growth: harnessing gravity to suppress convection. Crystal Growth & Design, 9(2), 885-888.

2008

Scholarly publications

Gros, P., Milder, F. J., & Janssen, B. J. C. (2008). Complement driven by conformational changes. Nature Reviews. Immunology, 8(1), 48-58. https://doi.org/10.1038/nri2231
Gros, P., Milder, F. J., & Janssen, B. J. C. (2008). Complement driven by conformational. Nature Reviews. Immunology, 8, 48-58.
https://dspace.library.uu.nl/bitstream/handle/1874/33095/16.pdf?sequence=1

2007

Scholarly publications

Janssen, B. J. C., Read, R. J., Brünger, A. T., & Gros, P. (2007). Crystallography: Crystallographic evidence for deviating C3b structure. Nature, 448(7154). https://doi.org/10.1038/nature06102
Janssen, B. J. C., Halff, E. F., Lambris, J. D., & Gros, P. (2007). Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition. Journal of Biological Chemistry, 282, 29241-29247.
https://dspace.library.uu.nl/bitstream/handle/1874/26832/06.pdf?sequence=1
Hadders, M. A., Beringer, D., & Gros, P. (2007). Structure of C8α-MACPF Reveals Mechanism of Membrane Attack in Complement Immune Defense. Science, 317, 1552-1554.
https://dspace.library.uu.nl/bitstream/handle/1874/26831/03.pdf?sequence=1
Rooijakkers, S. H. M., Milder, F. J., Bardoel, B. W., Ruyken, M., van Strijp, J. A. G., & Gros, P. (2007). Staphylococcal complement inhibitor: structure and active sites. Journal of Immunology, 179(5), 2989-2998.
https://dspace.library.uu.nl/bitstream/handle/1874/26148/13.pdf?sequence=1
Milder, F. J., Gomes, L., Schouten, A., Janssen, B. J. C., Huizinga, E. G., Romijn, R. A., Hemrika, W., Roos, A., Daha, M. R., & Gros, P. (2007). Factor B structure provides insights into activation of the central protease of the complement system. Nature Structural and Molecular Biology, 14, 224-228.
https://dspace.library.uu.nl/bitstream/handle/1874/26877/08.pdf?sequence=1
Morlot, C., Thielens, N. M., Ravelli, R. B. G., Hemrika, W., Romijn, R. A., Gros, P., Cusack, S., & McCarthy, A. A. (2007). Structural insights into the Slit-Robo complex. Proceedings of the National Academy of Sciences of the United States of America, 5, 1538-1544.
https://dspace.library.uu.nl/bitstream/handle/1874/26888/11.pdf?sequence=1
Janssen, B. J. C., Read, R. J., Brunger, A. T., & Gros, P. (2007). Crystallographic evidence for deviating C3b structure? Nature, 448, E1-E2.
https://dspace.library.uu.nl/bitstream/handle/1874/26876/07.pdf?sequence=1
Morlot, C., Hemrika, W., Romijn, R. A., Gros, P., Cusack, S., & McCarthy, A. A. (2007). Production of Slit2 LRR domains in mammalian cells for structural studies and the structure of human Slit2 domain 3. Acta crystallographica. Section D, biological crystallography, D63, 961-978.
https://dspace.library.uu.nl/bitstream/handle/1874/26887/10.pdf?sequence=1
Arlaud, G. J., Barlow, P. N., Gaboriaud, C., Gros, P., & Narayana, S. V. L. (2007). Deciphering complement mechanisms: The contributions of structural biology. Molecular Immunology, 44, 3809-3822.
https://dspace.library.uu.nl/bitstream/handle/1874/26830/01.pdf?sequence=1
Herczenik, E., Bouma, B., Korporaal, J. A., Strangi, R., Zeng, Q., Gros, P., van Eck, M., van Berkel, T. J. C., Gebbink, M. F. B. G., & Akkerman, J. W. N. (2007). Activation of human platelets by misfolded proteins. Arteriosclerosis, Thrombosis and Vascular Biology, 27, 1657-1665.
https://dspace.library.uu.nl/bitstream/handle/1874/26090/04.pdf?sequence=1
Morlot, C., Hemrika, W., Romijn, R. A., Gros, P., Cusack, S., & McCarthy, A. A. (2007). Cloning, expression, crystallization and preliminary X-ray analysis of the first two Ig domains from human Roundabout 1 (Robo1). Acta crystallographica. Section F, Structural biology and crystallization communications, F63, 689-691.
https://dspace.library.uu.nl/bitstream/handle/1874/26886/09.pdf?sequence=1

2006

Scholarly publications

Janssen, B. J. C., & Gros, P. (2006). Conformational complexity of complement component C3. Advances in Experimental Medicine and Biology, 586, 291-312. https://doi.org/10.1007/0-387-34134-X_20
van Ulsen, J. P., Gros, P., & Tommassen, J. P. M. (2006). Structure and function of the translocator domain of bacterial autotransporters. In R. Grisshammer, & S. Buchanan (Eds.), Structural biology of membrane proteins (pp. 270-287). RSC.
Brown, K. M., Kondeatis, E., Vaughan, R. W., Kon, S. P., Farmer, C. K. T., Taylor, J. D., He, X., Johnston, A., Horsfield, C., Janssen, B. J. C., Gros, P., Zhou, W., Sacks, S. H., & Sheerin, N. S. (2006). Influence of Donor C3 Allotype on Late Renal-Transplantation Outcome. New England Journal of Medicine, 354, 2014-2023.
https://dspace.library.uu.nl/bitstream/handle/1874/20064/2006-Brown-NEJM.pdf?sequence=1
Janssen, B. J. C., & Gros, P. (2006). Structural insights into the central complement component C3. Molecular Immunology, 44, 3-10.
https://dspace.library.uu.nl/bitstream/handle/1874/20067/10.1016-j.molimm.2006.06.017.pdf?sequence=1
Wirtz, K. W. A., Schouten, A., & Gros, P. (2006). Phosphatidylinositol transfer proteins: From closed for transport to open for exchange. Advances in Enzyme Regulation, 46, 301-311.
https://dspace.library.uu.nl/bitstream/handle/1874/20027/5.Wirtz%25202006%2520pp301-311.pdf?sequence=1
Milder, F. J., Raaijmakers, H. C. A., Vandeputte, D. A. A., Schouten, A., Huizinga, E. G., Romijn, R. A., Hemrika, W., Roos, A., Daha, M. R., & Gros, P. (2006). Structure of complement component C2a: implications for convertase formation and substrate binding. Structure, 14(10), 1587-1597.
https://dspace.library.uu.nl/bitstream/handle/1874/20068/10.1016-j.str.2006.08.008.pdf?sequence=1
Janssen, B. J. C., Christodoulidou, A., McCarthy, A. A., Lambris, J. D., & Gros, P. (2006). Structure of C3b reveals conformational changes that underlie complement activity. Nature, 444, 213-216.
https://dspace.library.uu.nl/bitstream/handle/1874/20065/10.1038-nature05172.pdf?sequence=1
Rutten, L., Geurtsen, J. J. G., Lambert, W., Smolenaers, J. J. M., Bonvin, A. M., de Haan, A., van der Ley, P., Egmond, M. R., Gros, P., & Tommassen, J. P. M. (2006). Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America, 103, 7071-7076. https://doi.org/10.1073/pnas.0509392103
Janssen, B. J. C., & Gros, P. (2006). Conformational complexity of complement component C3. In J. D. Lambris (Ed.), Current topics in complement (pp. 291-312). (Advances in experimental medicine and biology; No. 586). Springer.
https://dspace.library.uu.nl/bitstream/handle/1874/20066/2006-Janssen-AEMB.pdf?sequence=1

2005

Scholarly publications

Oomen, C. J., Hoogerhout, P., Kuipers, B., Vidarsson, G., van Alphen, L., & Gros, P. (2005). Crystal Structure of an Anti-meningococcal Subtype P1.4 PorA Antibody Provides Basis for Peptide-Vaccine Design. Journal of Molecular Biology, 351, 1070-1080. https://doi.org/10.1016/j.jmb.2005.06.061
Janssen, B. J. C., Huizinga, E. G., Raaijmakers, H. C. A., Roos, A., Daha, M. R., Nilsson-Ekdahl, K., Nilsson, B., & Gros, P. (2005). Structures of complement component C3 provide insights into the function and evolution of immunity. Nature, 437, 505-511.
https://dspace.library.uu.nl/bitstream/handle/1874/14832/nature04005.pdf?sequence=2
Weik, M., Schreurs, A. M. M., Leiros, H-K. S., Zaccai, G., Ravelli, R. B. G., & Gros, P. (2005). Supercooled liquid-like solvent in trypsin crystals: implications for crystal annealing and temperature-controlled Z-ray radiation damage studies. Journal of Synchrotron Radiation, 12, 310-317. https://doi.org/10.1107/S0909049505003316

2004

Scholarly publications

Oomen, C. J., van Ulsen, J. P., van Gelder, P., Feijen, M., Tommassen, J. P. M., & Gros, P. (2004). Structure of the translocator domain of a bacterial autotransporter. EMBO Journal, 23, 1257-1266.
https://dspace.library.uu.nl/bitstream/handle/1874/14583/10.1038-sj.emboj.7600148.pdf?sequence=1
Scheres, S. H. W., & Gros, P. (2004). The potentials of conditional optimization in phasing and model building of protein crystal structures. Acta crystallographica. Section D, biological crystallography, 60, 2202-2209.
https://dspace.library.uu.nl/bitstream/handle/1874/14635/10.1107-S0907444904008996.pdf?sequence=1

Other output

Valentijn, K. M., de Koning, R., Derks, Y., van Doorn, J. M., Schouten, A., Koerten, H. K., van der Horst, D. J., Gros, P., Koster, A. J., & Rodenburg, C. W. (2004). Preliminary model of the three-dimensional structure insect lipoprotein HDLp by combining electron microscopy and X-ray crystallography. 327-328. Abstract from 13th European Microscopy Congress, University of Antwerp, Belgium.
Valentijn, K. M., de Koning, R., Derks, Y., van Doorn, J. M., Schouten, A., Koerten, H. K., van der Horst, D. J., Gros, P., Koster, A. J., & Rodenburg, C. W. (2004). Preliminary three-dimensional model of insect lipoprotein HDLp by using electron microscopy and X-ray crystallography. 11514-11515. Abstract from 62th Annual Meeting of the Microscopy Society of America, Savanna, Georgia, USA.

2003

Scholarly publications

Vandeputte-Rutten, L., Bos, M. P., Tommassen, J. P. M., & Gros, P. (2003). Crystal structure of neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential. Journal of Biological Chemistry, 278(27), 24825-24830.
https://dspace.library.uu.nl/bitstream/handle/1874/14289/10.1074-jbc.M302803200.pdf?sequence=1
Scheres, S. H. W., & Gros, P. (2003). Development of a force field for conditional optimization of protein structure. Acta crystallographica. Section D, biological crystallography, 59, 438-446.
Dekker, C. G., de Kruijff, B., & Gros, P. (2003). Crystal structure of SecB from Escherichia coli. Journal of Structural Biology, 144, 313-319.
https://dspace.library.uu.nl/bitstream/handle/1874/14368/Dekker-Crystal%2520structure.pdf?sequence=1
Agianian, B., Tucker, P. A., Schouten, A., Leonard, K., Bullard, B., & Gros, P. (2003). Structure of a Drosophila Sigma Class Glutathione S-transferase Reveals a Novel Active Site Topography Suited for Lipid Peroxidation Products. Journal of Molecular Biology, 326, 151-165.
https://dspace.library.uu.nl/bitstream/handle/1874/14290/10.1016-S0022-2836%2802%2901327-X.pdf?sequence=1
Oomen, C. J., Hoogerhout, P., Bonvin, A. M. J. J., Kuipers, B., Brughhe, H., Timmermans, H., Hasely, S. R., van Alphen, L., & Gros, P. (2003). Immunogenicity of peptide-vaccine candidates predicted by molecular dynamics simulations. Journal of Molecular Biology, 328, 1083-1089. https://doi.org/10.1016/S0022-2836(03)00377-2

2002

Scholarly publications

van Tiel, C. M., Schouten, A., Snoek, G. T., Gros, P., & Wirtz, K. W. A. (2002). The structure of phosphatidylinositol transfer protein α reveals sites for phospholipid binding and membrane association with major implications for its function. FEBS Letters, 531, 69-73.
https://dspace.library.uu.nl/bitstream/handle/1874/14283/12.Van%2520Tiel%25202002%2520pp%252069-73.pdf?sequence=1
Kramer, R. A., Brandenburg, K., Vandeputte-Rutten, L., Werkhoven, M., Gros, P., Dekker, N., & Egmond, M. R. (2002). Lipopolysaccharide regions involved in the activation of Escherichia coli outer membrane protease OmpT. European Journal of Biochemistry, 269, 1746-1752.
https://dspace.library.uu.nl/bitstream/handle/1874/14272/9.Kramer2002%2520pp1746-52.pdf?sequence=1
Vandeputte-Rutten, L., & Gros, P. (2002). Novel proteases: common themes and surprising features. Current Opinion in Structural Biology, 12, 704-708.
https://dspace.library.uu.nl/bitstream/handle/1874/14284/Vandeputte_p704-708_02.pdf?sequence=1
Huizinga, E. G., Tsuji, S., Romijn, R. A. P., Schiphorst, M. E., de Groot, P. G., Sixma, J. J., & Gros, P. (2002). Structures of glycoprotein Ibα and its complex with von Willebrand Factor A1 domain. Science, 297, 1176-1179.
https://dspace.library.uu.nl/bitstream/handle/1874/14142/Huizinga_p1176-1179_02.pdf?sequence=1
Schouten, A., Agianian, B., Westerman, J., Kroon, J., Wirtz, K. W. A., & Gros, P. (2002). Structure of apo-phosphatidylinositol transfer protein α provides insight into membrane association. EMBO Journal, 21(9), 2117-2121.
https://dspace.library.uu.nl/bitstream/handle/1874/14281/10Schouten%25202002%2520pp%25202117-2121.pdf?sequence=1
Weik, M., Berges, J., Raves, M., Gros, P., McSweeney, S., Silman, I., Sussman, J. L., Houee-Levin, C., & Ravelli, R. B. G. (2002). Evidence for the formation of disulfide radicals in protein crystals upon X-ray irridiation. Journal of Synchrotron Radiation, 9, 342-346.

Other output

Bos, M. P., Vandeputte-Rutten, L., Gros, P., & Tommassen, J. P. M. (2002). Structure-function analysis of the neisserial surface protein A.. Abstract from Thirteenth International Pathogenic Neisseria Cnference, Oslo, Norway.

2001

Scholarly publications

Huizinga, E. G., Schouten, A., Connolly, T. M., Kroon, J., Sixma, J. J., & Gros, P. (2001). The structure of leech anti-platelet protein, an inhibitor of haemostasis. Acta Crystallographica Section D: Biological Crystallography, 57(8), 1071-1078. https://doi.org/10.1107/S0907444901007405
Romijn, R. A. P., Bouma, B., Wuyster, W., Gros, P., Kroon, J., Sixma, J. J., & Huizinga, E. G. (2001). Identification of the collagen-binding site of the von Willebrand Factor A3-domain. Journal of Biological Chemistry, 276, 9985-9991.
Vandeputte-Rutten, L., Kramer, R. A., Kroon, J., Dekker, N., Egmond, M. R., & Gros, P. (2001). Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site EMBO Journal. EMBO Journal, 20, 5033-5039.
Kroon, J., Weik, M., Kryger, G., Schreurs, A. M. M., Bouma, B. N., Silman, I., Sussman, J. L., & Gros, P. (2001). Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures. Acta Crystallographica, D57, 566-573.
Kroon, J., Weik, M., Ravelli, R. B. G., Silman, I., Sussman, J. L., & Gros, P. (2001). Specific protein dynamics near the solvent glass transition assayed by radiation-induced structural changes. Protein Science, 10, 1953-1961.
Kramer, R. A., Vandeputte-Rutten, L., de Roon, G. J., Gros, P., Dekker, N., & Egmond, M. R. (2001). Identification of essential acidic residues of outer membrane protease OmpT supports a novel active site. FEBS Letters, 505, 426-430.
Bouma, B. N., Westerman, J., Dekker, N., Gros, P., & Wirtz, K. W. A. (2001). Activation of phosphatidylinositol transfer protein alfa and beta isoforms from inclusion bodies. Biochimica et Biophysica Acta, 1546, 216-225.
Agianian, B., Weik, M., Zaccai, G., Kroon, J., de Kruijff, B., & Gros, P. (2001). Biophysical characterization of the influence of salt on tetrameric SecB. Biophysical Journal, 81, 455-462.
Huizinga, E. G., Schouten, A., Connolly, T. M., Kroon, J., Sixma, J. J., & Gros, P. (2001). The structure of leech anti-plated protein, an inhibitor of haemostasis. Acta crystallographica. Section D, biological crystallography, D 57, 1071-1078.
Brunger, A. T., Adams, P. D., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J-S., Pannu, N. S., Read, R. J., Rice, L. M., & Simonson, T. (2001). The structure determination language of the crystallography anf NMR system. In M. G. Rossmann, & E. Arnolds (Eds.), International Tables for X-ray Crystallography (Volume F) Crystallography of Biological Macromolecules Kluwer Academic Publishers.
Scheres, S. H. W., & Gros, P. (2001). Conditional optimization: a new formalism for protein structure refinement. Acta Crystallographica, D57, 1820-1828.

Professional publications

Agianian, B., Clayton, P., Leonard, J. M., Tucker, P. A., & Gros, P. (Accepted/In press). Crystallization and preliminary X-ray analysis of Drosophila glutathione S-transferase-2. Acta crystallographica. Section D, biological crystallography, D57, 725-727.

2000

Scholarly publications

Weik, M., Ravelli, R. B. G., Kryger, G., McSweeney, S., Raves, M., Harel, M., Gros, P., Silman, I., Kroon, J., & Sussman, J. L. (2000). Specific chemical and structural damage to proteins produced by synchrotron radiation. Proceedings of the National Academy of Sciences of the United States of America, 97, 623-628.
de Groot, P. G., Bouma, B. N., Lutters, B. C. H., Simmelink, M. J. A., Derksen, R. H. W. M., & Gros, P. (2000). Structure-function studies on B2-glycoprotein I. Journal of Autoimmunity, 15, 87-89.
Oomen, C. J., Bonvin, A. M. J. J., Haseley, S. R., Hoogerhout, P., van Alphen, L., Kroon, J., & Gros, P. (2000). Rational design of a subtype-specific peptide vaccine against Neisseria meningitidis. In J. P. T. G. Barany G.B. Fields (Ed.), Peptides for a New Millenium (pp. 702-703). Kluwer Academic Publishers. https://doi.org/10.1007/0-306-46881-6_280
de Groot, P. G., Bouma, B., Lutters, B. C. H., Simmelink, M. J. A., Derksen, R. H. W. M., & Gros, P. (2000). Structure-function studies on beta2-Glycoprotein I. Journal of Autoimmunity, 15, 87-89.

Popularising publications

Kroon, J., & Gros, P. (2000). "Sneak Preview" Stralingsschade. Chemsch2Weekblad 4, 5-5.

1999

Scholarly publications

Bouma, B., de Groot, P. G., van den Elsen, J. M. H., Ravelli, R. B. G., Schouten, A., Simmelink, M. J. A., Derksen, R. H. W. M., Kroon, J., & Gros, P. (1999). Adhesion of human beta2-Glycoprotein I to phospholipids based on its crystal structure. EMBO Journal, 18, 5166-5174.
Dekker, C. G., de Korte-Kool, G., Kroon, J., de Kruijff, B., & Gros, P. (1999). Crystals of acetylated SecB diffract to 2.3 Angstrom resolution. Journal of Structural Biology, 127, 237-242.
van den Elsen, J. M. H., Vandeputte-Rutten, L., Kroon, J., & Gros, P. (1999). Bactericidal antibody recognition of meningococcal PorA by induced fit: comparison of liganded and unliganded Fab structures. Journal of Biological Chemistry, 274, 1495-1501.
Bouma, B. N., de Groot, P. G., van den Elsen, J. M. H., Ravelli, R. B. G., Simmelink, M. J. A., Derksen, R. H. W. M., Kroon, J., & Gros, P. (1999). Adhesion mechanism of human beta 2-glycoprotein I to phospholipids based on its crystal structure. EMBO Journal, 18, 5166-5174.

1998

Scholarly publications

Brünger, A. T., Adams, P. D., Clore, G. M., Delano, W. L., Gros, P., Grossekunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., & Warren, G. L. (1998). Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallographica Section D: Biological Crystallography, 54(5), 905-921. https://doi.org/10.1107/S0907444998003254
Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J-S., Kuszweski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., & Warren, G. L. (1998). Crystallography and NMR System: a new software system for macromolecular structure determination. Acta crystallographica. Section D, biological crystallography, D54, 905-921.
Werten, S., Stelzer, G., Goppelt, A., Langen, F. M., Gros, P., Timmers, H. T. M., van der Vliet, P. C., & Meisterernst, M. (1998). Interaction of PC4 with melted DNA inhibits transcription. EMBO Journal, 17, 5103-5111.

1997

Scholarly publications

Brandsen, J., Werten, S., van der Vliet, P. C., Meisterernst, M., Kroon, J., & Gros, P. (1997). C-Terminal domain of transcription cofactor PC4 reveals a dimeric ssDNA binding site. Nature Structural Biology, 4, 900-903.
van den Elsen, J. M. H., Herron, J. N., Hoogerhout, P., Poolman, J. T., Boel, E., Logtenberg, T., Wilting, J., Crommelin, D. J. A., Kroon, J., & Gros, P. (1997). Bactericidal Antibody Recognition of a PorA Epitope of Neisseria meningitidis: Crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide. Proteins: Structure function and bioinformatics, 29(1), 113-125.
Brandsen, J., Werten, S., van der Vliet, P. C., Meisterernst, M., Kroon, J., & Gros, P. (1997). C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. Nature Structural Biology, 4, 900-904.
Sixma, J. J., van Zanten, G. H., Huizinga, E. G., van der Plas, R. M., Verkleij, M., Wu, Y. P., Gros, P., & de Groot, P. G. (1997). Platelet adhesion to collagen: an update. Thrombosis and Haemostasis, 78, 434-438.
Huizinga, E. G., van der Plas, R. M., Kroon, J., Sixma, J. J., & Gros, P. (1997). Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding. Structure, 5, 1147-1156.

1996

Scholarly publications

Teplyakov, A., Gros, P., & Hoi, W. G. J. (1996). Crystallographic study of eglin-C binding to thermitase. Advances in Experimental Medicine and Biology, 379, 5-9. https://doi.org/10.1007/978-1-4613-0319-0_2

1994

Scholarly publications

Van Gunsteren, W. F., Brunne, R. M., Gros, P., Van Schaik, R. C., Schiffer, C. A., & Torda, A. E. (1994). Accounting for molecular mobility in structure determination based on nuclear magnetic resonance spectroscopic and X-ray diffraction data. Methods in Enzymology, 239(C), 619-654. https://doi.org/10.1016/S0076-6879(94)39024-X

1993

Scholarly publications

Gros, P., & Van Gunsteren, W. F. (1993). Crystallographic refinement and structure-factor time-averaging by molecular dynamics in the absence of a physical force field. Molecular Simulation, 10(2-6), 377-395. https://doi.org/10.1080/08927029308022174

1992

Scholarly publications

Gros, P., Teplyakov, A. V., & Hol, W. G. J. (1992). Effects of eglin‐c binding to thermitase: Three‐dimensional structure comparison of native thermitase and thermitase eglin‐c complexes. Proteins: Structure, Function, and Bioinformatics, 12(1), 63-74. https://doi.org/10.1002/prot.340120108

1991

Scholarly publications

Gros, P., Kalk, K. H., & Hol, W. G. J. (1991). Calcium binding to thermitase: Crystallographic studies of thermitase at 0, 5, and 100 mM calcium. Journal of Biological Chemistry, 266(5), 2953-2961.
van Gunsteren, W. F., Gros, P., Torda, A. E., Berendsen, H. J., & van Schaik, R. C. (1991). On deriving spatial protein structure from NMR or X-ray diffraction data. Ciba Foundation symposium, 161, 150-159.

1990

Scholarly publications

Gros, P., Van Gunsteren, W. F., & Hol, W. G. J. (1990). Inclusion of thermal motion in crystallographic structures by restrained molecular dynamics. Science, 249(4973), 1149-1152. https://doi.org/10.1126/science.2396108

1989

Scholarly publications

Gros, P., Fujinaga, M., Dijkstra, B. W., Kalk, K. H., & Hol, W. G. J. (1989). Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c. Acta Crystallographica Section B, 45(5), 488-499. https://doi.org/10.1107/S0108768189006038
Gros, P., Betzel, C., Dauter, Z., Wilson, K. S., & Hol, W. G. J. (1989). Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 Å resolution and comparison of two crystal forms that differ in calcium content. Journal of Molecular Biology, 210(2), 347-367. https://doi.org/10.1016/0022-2836(89)90336-7

1988

Scholarly publications

Gros, P., Groendijk, H., Drenth, J., & Hol, W. G. J. (1988). Experiments in membrane protein crystallization. Journal of Crystal Growth, 90(1-3), 193-200. https://doi.org/10.1016/0022-0248(88)90315-6

1987

Scholarly publications

Kelders, H. A., Kalk, K. H., Gros, P., & Hol, W. G. J. (1987). Automated protein crystallization and a new crystal form of a subtilisin:eGlin complex. Protein Engineering, Design and Selection, 1(4), 301-303. https://doi.org/10.1093/protein/1.4.301

1985

Scholarly publications

BOELENS, R., GROS, P., SCHEEK, RM., VERPOORTE, JA., & KAPTEIN, R. (1985). HYDROGEN-EXCHANGE OF INDIVIDUAL AMIDE PROTONS IN THE ESCHERICHIA-COLI LAC REPRESSOR DNA-BINDING DOMAIN - A NUCLEAR MAGNETIC-RESONANCE STUDY. Journal of Biomolecular Structure and Dynamics, 3(2), 269-280.

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