dr. N.I. (Nynke) Kramer
Gegenereerd op 2018-08-14 19:51:03


Nynke Kramer is assistant professor at the Toxicology Division of the Institute for Risk Assessment Sciences (IRAS) of Utrecht University and heads its In Vitro Toxicology group. Her research focusses on developing and improving in vitro models for toxicological risk assessment. She teaches toxicokinetics, pharmacokinetic modeling, quantitative in vitro-in vivo extrapolation (QIVIVE), ecotoxicology and toxicological risk assessment at graduate and postgraduate level at the Faculties of Science, Medicine and Veterinary Medicine. 

Strategic themes / Focus areas
Involved in the following study programme(s)
Veterinary Medicine (Bachelor)
Veterinary Science Postgraduate Master
Scientific expertise
Gegenereerd op 2018-08-14 19:51:03
Curriculum vitae

Nynke Kramer is assistant professor in Toxicology at the Institute for Risk Assessment Sciences (IRAS) of Utrecht University. Nynke heads its 'In Vitro Toxicology' group. She teaches toxicokinetics, pharmacokinetic modeling, ecotoxicology, toxicological risk assessment and quantitative in vitro-in vivo extrapolation at graduate and postgraduate level. Her research focuses on developing techniques and models to improve the extrapolation of effect concentrations obtained from in vitro cell assays to toxic doses relevant to humans and animals. Her current research follows up on her PhD thesis, completed at the same institute in 2010. Her research has led to a number of publications uncovering parameters determining the free concentration of test chemicals in in vitro cell assays. The issue of free concentrations in in vitro assays has slowly picked up momentum. Illustratively, Nynke’s research has been awarded the SETAC Procter and Gamble 2007 Fellowship for Doctoral Research in Environmental Sciences. She used the prize money to do part of her research at the Swiss Federal Institute for Aquatic Science and Technology, Eawag, Dübendorf, Switzerland. Before starting her PhD, Nynke obtained her BSc degree (summa cum laude) in Life Sciences at University College Utrecht in 2003 and her MSc degree (distinction) in Environmental Change and Management at the University of Oxford in 2004. 

Gegenereerd op 2018-08-14 19:51:03
All publications
  2015 - Articles
Pike, Adrianne F, Kramer, Nynke I, Blaauboer, Bas J, Seinen, Willem & Brands, Ruud (25.01.2015). An alkaline phosphatase transport mechanism in the pathogenesis of Alzheimer's disease and neurodegeneration. Chemico-Biological Interactions, 226C, (pp. 30-39) (10 p.). Copyright © 2014 Elsevier Ireland Ltd. All rights reserved..
Kramer, Nynke I, Di Consiglio, Emma, Blaauboer, Bas J & Testai, Emanuela (25.12.2015). Biokinetics in repeated-dosing in vitro drug toxicity studies. Toxicology in Vitro, 30 (1 Pt A), (pp. 217-24) (8 p.). Copyright © 2015 Elsevier B.V. All rights reserved..
Groothuis, Floris, Heringa, M.B., Nicol, B, Hermens, Joop, Blaauboer, B & Kramer, Nynke (05.06.2015). Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations. Toxicology, 332, (pp. 30-40) (11 p.).
  2014 - Articles
Chen, Yi, Geurts, Marc, Sjollema, Sascha B., Kramer, Nynke, Hermens, Joop & Droge, Steven (2014). Acute toxicity of the cationic surfactant C12-benzalkonium in different bioassays: How test design affects bioavailability and effect concentrations. Environmental Toxicology and Chemistry, 33 (3), (pp. 606-615) (9 p.).
Bessems, Jos G., Loizou, George, Krishnan, Kannan, Clewell, Harvey J., Bernasconi, Camilla, Bois, Frederic, Coecke, Sandra, Collnot, Eva Maria, Diembeck, Walter, Farcal, Lucian Romeo, Geraets, Liesbeth, Gundert-Remy, Ursula, Kramer, Nynke, Küsters, Gabriele, Leite, Sofia B., Pelkonen, Olavi R., Schröder, Klaus, Testai, Emanuela, Wilk-Zasadna, Iwona & Zaldívar-Comenges, José Manuel (01.02.2014). PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment. Recommendations from a joint EPAA - EURL ECVAM ADME workshop. Regulatory Toxicology and Pharmacology, 68 (1), (pp. 119-139) (21 p.).
  2013 - Articles
Pike, A.F., Kramer, N.I., Blaauboer, B.J., Seinen, W. & Brands, R. (2013). A novel hypothesis for an alkaline phosphatase 'rescue' mechanism in the hepatic acute phase immune response. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1832 (12), (pp. 2044-2056) (13 p.).
  2012 - Articles
Knöbel, M., Busser, F.J.M., Rico-Rico, A., Kramer, N.I., Hermens, J.L.M., Hafner, C., Tanneberger, K., Schirmer, K. & Scholz, S. (2012). Predicting adult fish acute lethality with the zebrafish embryo: relevance of test duration, endpoints, compound properties, and exposure concentration analysis. Environmental Science & Technology, 46 (17), (pp. 9690-9700) (11 p.).
Kramer, N.I., Krismartina, M., Rico-Rico, A., Blaauboer, B.J. & Hermens, J.L.M. (2012). Quantifying processes determining the free concentration of phenanthrene in Basal cytotoxicity assays. Chemical Research in Toxicology, 25 (2), (pp. 436-445) (10 p.).
Blaauboer, B.J., Boekelheide, K., Clewell, H.J., Daneshian, M., Dingemans, M.M.L., Goldberg, A.M., Heneweer, M., Jaworska, J., Kramer, N.I., Leist, M., Seibert, H., Testai, E., Vandebriel, R.J., Yager, J.D. & Zurlo, J. (2012). The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans. ALTEX-Alternatives to Animal Experimentation, 29 (4), (pp. 411-425) (15 p.).
  2010 - Articles
Kramer, N.I., Busser, F.J.M., Oosterwijk, M.T., Schirmer, K., Escher, B.I. & Hermens, J.L.M. (2010). Development of a partition-controlled dosing system for cell assays. Chemical Research in Toxicology, 23 (11), (pp. 1806-1814) (11 p.).
Tanneberger, K., Rico Rico, A., Kramer, N.I., Busser, F.J.M., Hermens, J.L.M. & Schirmer, K. (2010). Effects of solvents and dosing procedure on chemical toxicity in cell-based in vitro assays. Environmental Science & Technology, 44 (12), (pp. 4775-4781) (7 p.).
  2009 - Articles
Nichols, J.W., Bonnell, M., Dimitrov, S., Escher, B., Han, X. & Kramer, N.I. (2009). Bioaccumulation assessment using predictive approaches. Integrated Environmental Assessment and Management, 5 (4), (pp. 577-597) (21 p.).
Kramer, N.I., Hermens, J.L.M. & Schirmer, K. (2009). The influence of modes of action and physicochemical properties of chemicals on the correlation between in vitro and acute fish toxicity data. Toxicology in Vitro, 23 (7), (pp. 1372-1379) (8 p.).
  2008 - Articles
Schirmer, K., Tanneberger, K., Kramer, N.I., Volker, D., Scholz, S., Hafner, C., Lee, L.E., Bols, N.C. & Hermens, J.L.M. (2008). Developing a list of reference chemicals for testing alternatives to whole fish toxicity tests. Aquatic Toxicology, 90 (2), (pp. 128-137) (10 p.).
  2007 - Articles
Kramer, N.I., Eijkeren, J.C.H. & Hermens, J.L.M. (2007). Influence of albumin on sorption kinetics in solid-phase microextraction: consequenses for chemical analyses and uptake processes. Analytical Chemistry, 79 (18), (pp. 6941-6948) (8 p.).
  0 - Prize (including medals and awards)
Kramer, N.I. 2007 Recipient SETAC fellowship award has been received for proposal on: Bioavailability in cellular assays: consequences for effects in in vitro assays.
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Gegenereerd op 2018-08-14 19:51:04

Nynke Kramer lectures and supervises practical classes about toxicokinetics, hepatotoxicity, methods in toxicological hazard characterization, PBPK modeling, and quantitative in vitro-in vivo extrapolation. These subjects are taught in Toxicology courses for BSc students majoring in Biology, Biomedical Sciences and Veterinary Medicine as well as in the courses Exposure Assessment and Risk Assessment and Management for Master students Toxicology and Environmental Health and for students attending the Summer School Toxicology and Environmental Health.

Gegenereerd op 2018-08-14 19:51:04
Full name
dr. N.I. Kramer Contact details
Jeannette Donker-Voetgebouw

Yalelaan 104-106
Room 1032
The Netherlands

Phone number (direct) +31 30 253 5314
Jeannette Donker-Voetgebouw

Yalelaan 104-106
Room 1.032
The Netherlands

Phone number (direct) +31 30 253 5314


twitter: @iras_uu

Gegenereerd op 2018-08-14 19:51:04
Last updated 31.08.2017