M.W.H.C. (Marianne) Bol-Schoenmakers
Junior Assistant Professor

Gegenereerd op 2018-03-21 15:45:06


Marianne Bol-Schoenmakers werkt binnen immunotoxicologie van het Insitute for Risk Assessment Sciences (IRAS) en houdt zich met name bezig met onderzoek naar de ongewenste effecten van verschillende agentia (o.a. medicijnen, voedings componenten) op het afweersysteem van de darm.

Daarnaast is ze coördinator van de BSc cursus Toxicologie die bij Biologie en Biomedische wetenschappen worden verzorgd vanuit het IRAS, en draagt ze bij aan de BSc cursussen die bij Diergeneeskunde en Geowetenschappen worden verzorgd. Ook is ze betrokken bij het cursorisch onderwijs binnen de master Toxicology and Environmental Health, en het begeleiden van stages van master studenten.

Involved in the following study programme(s)
Scientific expertise
Gegenereerd op 2018-03-21 15:45:06
All publications
  Articles - 2018
Giustarini, Giulio, Kruijssen, Laura, van Roest, Manon, Bleumink, Rob, Weaver, Richard J, Bol-Schoenmakers, Marianne, Smit, Joost & Pieters, Raymond (26.01.2018). Tissue influx of neutrophils and monocytes is delayed during development of trovafloxacin-induced tumor necrosis factor-dependent liver injury in mice. Journal of applied toxicology Copyright © 2018 John Wiley & Sons, Ltd..
  Articles - 2017
Hammerschmidt-Kamper, Christiane, Biljes, Daniel, Merches, Katja, Steiner, Irina, Daldrup, Thomas, Bol-Schoenmakers, Marianne, Pieters, Raymond H. H. & Esser, Charlotte (01.06.2017). Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice. PLoS One, 12 (6) (17 p.).
  Articles - 2016
Kwast, Lydia, Fiechter, Daniëlle, Kruijssen, Laura, Bleumink, Rob, Ludwig, Irene, Bol-Schoenmakers, Marianne, Smit, Joost & Pieters, Raymond (04.04.2016). Oral exposure to immunostimulating drugs results in early changes in innate immune parameters in the spleen. Journal of Immunotoxicology, 13 (4), (pp. 535-47) (13 p.).
Bol-Schoenmakers, M, Braber, S, Akbari, P, de Graaff, P, van Roest, M, Kruijssen, L, Smit, J J, van Esch, B C A M, Jeurink, P V, Garssen, J, Fink-Gremmels, J & Pieters, R H H (17.02.2016). The mycotoxin deoxynivalenol facilitates allergic sensitization to whey in mice. Mucosal Immunology
  Articles - 2014
van den Elsen, Lieke Wj, Bol-Schoenmakers, Marianne, van Esch, Betty Cam, Hofman, Gerard A, van de Heijning, Bert Jm, Pieters, Raymond H, Smit, Joost J, Garssen, Johan & Willemsen, Linette Em (2014). DHA-Rich Tuna Oil Effectively Suppresses Allergic Symptoms in Mice Allergic to Whey or Peanut. Journal of Nutrition, 144 (12), (pp. 1970-6) (7 p.).
  Articles - 2013
Schulz, V.J., van Roest, M., Bol-Schoenmakers, M., van Duursen, M.B.M., van den Berg, M., Pieters, R.H.H. & Smit, J.J. (2013). Aryl hydrocarbon receptor activation affects the dendritic cell phenotype and function during allergic sensitization. Immunobiology, 218 (8), (pp. 1055-1062) (8 p.).
  Articles - 2012
Schulz, V.J., Smit, J.J., Bol-Schoenmakers, M., van Duursen, M.B.M., van den Berg, M. & Pieters, R.H.H. (2012). Activation of the aryl hydrocarbon receptor reduces the number of precursor and effector T cells, but preserves thymic CD4(+)CD25(+)Foxp3(+) regulatory T cells. Toxicology Letters, 215 (2), (pp. 100-109) (10 p.).
Schulz, V.J., Smit, J.J., Huijgen, V.C., Bol-Schoenmakers, M., van Roest, M., Kruijssen, L.W.J., Fiechter, D., Hassing, I., Bleumink, A.R.J., Safe, S., van Duursen, M.B.M., van den Berg, M. & Pieters, R.H.H. (2012). Non-dioxin-like AhR ligands in a mouse peanut allergy model. Toxicological Sciences, 128 (1), (pp. 92-102) (11 p.).
  Articles - 2011
Marcondes Rezende, M., Hassing, I., Bol-Schoenmakers, M., Bleumink, R., Boon, L, van Bilsen, J. & Pieters, R. (2011). CD4(+) CD25(+) T regulatory cells do not transfer oral tolerance to peanut allergens in a mouse model of peanut allergy. Clinical and Experimental Allergy, 41 (9), (pp. 1324-1333) (10 p.).
Bol-Schoenmakers, M., Bleumink, R., Marcondes Rezende, M., Mouser, E., Hassing, I., Ludwig, I.S., Smit, J.J. & Pieters, R.H.H. (2011). Diclofenac enhances allergic responses in a mouse peanut allergy model. Clinical and Experimental Allergy, 41 (3), (pp. 424-433) (10 p.).
Bol-Schoenmakers, M., Marcondes Rezende, M., Boon, L, Man, S., Hassing, I., Fiechter, D., Pieters, R.H.H. & Smit, J.J. (2011). Regulation by intestinal γδ T cells during establishment of food allergic sensitization in mice. Allergy: European Journal of Allergy and Clinical Immunology, 66 (3), (pp. 331-340) (10 p.).
Smit, J.J., Bol-Schoenmakers, M., Hassing, I., Fiechter, D., Boon, L., Bleumink, R. & Pieters, R. (2011). The role of intestinal dendritic cells subsets in the establishment of food allergy. Clinical and Experimental Allergy, 41 (6), (pp. 890-898) (9 p.).
  Articles - 2010
Bol-Schoenmakers, M., Fiechter, D., Raaben, W., Hassing, I., Bleumink, R., Kruijswijk, D., Maijoor, K., Tersteeg-Zijderveld, M., Brands, R. & Pieters, R. (2010). Intestinal alkaline phosphatase contributes to the reduction of severe intestinal epithelial damage. European Journal of Pharmacology, 633 (1-3), (pp. 71-77) (7 p.).
  Articles - 2008
de Haar, C., Kool, M., Hassing, I., Bol-Schoenmakers, M., Lambrecht, B.N. & Pieters, R.H.H. (2008). Lung dendritic cells are stimulated by ultrafine particles and play a key role in particle adjuvant activity. Journal of Allergy and Clinical Immunology, 121 (5), (pp. 1246-1254) (8 p.).
  Articles - 2006
de Haar, C.G., Hassing, I., Bol, M.W.H.C., Bleumink, R. & Pieters, R.H.H. (2006). Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clinical and Experimental Allergy, 36 (11), (pp. 1469-1479) (11 p.).
  Articles - 2005
Nierkens, S., Aalbers, M., Bol, M.W.H.C., van Wijk, F., Hassing, G.A.M. & Pieters, R.H.H. (2005). Development of an oral exposure mouse model to predict drug-induced hypersensitivity reactions by using reporter antigens. Toxicological Sciences, 83, (pp. 273-281) (9 p.).
Nierkens, S., Aalbers, M., Bol, M.W.H.C., Bleumink, A.R.J., van Kooten, P.J., Boon, L. & Pieters, R.H.H. (2005). Differential requirement for CD28/CTLA-4-CD80/CD86 interactions in drug-induced type 1 and type 2 immune response tot trinitrophenyl-ovalbumin. Journal of Immunology, 175, (pp. 3707-3714) (8 p.).
Nierkens, S., Bleumink, A.R.J., Bol-Schoenmakers, M., Hassing, G.A.M., van Rooijen, N. & Pieters, R.H.H. (2005). The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells. Chemical Research in Toxicology, 18, (pp. 872-879) (8 p.).
de Haar, C.G., Hassing, G.A.M., Bol-Schoenmakers, M., Bleumink, A.R.J. & Pieters, R.H.H. (2005). Ultrafine carbon black particles cause early airway inflammation and have adjuvant activity in a mouse allergic airway disease model. Toxicological Sciences, 87 (2), (pp. 409-418) (10 p.).
  Articles - 2003
Albers, R., Bol-Schoenmakers, M., Bleumink, A.R.J., Willems, A.A. & Pieters, R.H.H. (2003). Effects of supplementation with vitamins A, C, and E, selenium, and zinc on immune function in a murine sensitization model. Nutrition, 19, (pp. 940-946) (7 p.).
  Articles - 2002
Albers, R., Bol, M.W.H.C., Bleumink, R., Willems, A., Blonck, C. & Pieters, R. (2002). Effects of dietary lipids on immune function in a murine sensitisation model. British Journal of Nutrition, 88, (pp. 291-299) (9 p.).
Gennari, A., Bol, M.W.H.C., Seinen, W., Penninks, A. & Pieters, R. (2002). Organotin-induced apoptosis occurs in small CD4(+)CD8(+) thymocytes and is accompanied by an increase in RNA synthesis. Toxicology, 175, (pp. 191-200) (10 p.).
Pieters, R., Ezendam, J., Bleumink, R., Bol, M.W.H.C. & Nierkens, S. (2002). Predictive testing for autoimmunity. Toxicology Letters, 127, (pp. 83-91) (9 p.).
Nierkens, S., van Helden, P., Bol, M.W.H.C., Bleumink, R., van Kooten, P., Ramdien-Murli, S., Boon, L. & Pieters, R. (2002). Selective requirement for CD40-CD154 in drug-induced type 1 versus type 2 responses to trinitrophenyl-ovalbumin. Journal of Immunology, 168 (8), (pp. 3747-3754) (8 p.).
  Articles - 2000
van Zijverden, M., van der Pijl, A., Bol, M.W.H.C., van Pinxteren, F.A., de Haar, C.G., Penninks, A.H., van Loveren, H. & Pieters, R. (2000). Diesel exhaust, carbon black, and silica particles display distinct Th1/Th2 modulating activity. Toxicology and Applied Pharmacology, 168, (pp. 131-139) (9 p.).
  Lectures - 2015
M.W.H.C. Schoenmakers (13.09.2015) “Interaction between Intestinal Epithelial Cells and intraepithelial lymphocytes in food allergy: role of epithelial cell stress or damage in allergic sensitization” EUROTOX Porto, Portugal (51st congress of the European Societies of Toxicology), congress 13- 16 september 2015
  Doctoral thesis 1 (Research UU / Graduation UU) - 2009
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Gegenereerd op 2018-03-21 15:45:07

The Immunotoxicology group examines fundamental processes involved in immunosensitization and inflammatory responses by various agents, including drugs, environmental chemicals/pollutants and food components.

I am particularly interested in adverse effects of food components. Food allergy results from an abnormal immune response to food and this allergic reaction can sometimes cause serious illness and death. We investigate the role of various immune cells in the intestine such as (regulatory) T cells, intraepithelial lymphocytes and dendritic cells in the initiation and maintenance of food allergy by using established food allergy models in mice, as well as in vitro cell culture systems. Studying the interaction of the various immune cells with intestinal epithelial cells enables to determine processes that are responsible for the balance between oral tolerance en sensitization to food proteins.  In addition, the influence of environmental substances present in the intestine (such as bacterial components, AhR ligands, drugs (NSAIDs) and probiotics) on this balance is investigated. Knowledge on the risks and/or beneficial effects of these  components to intestinal health might contribute to possible therapeutic interventions for food allergy.

Research in this project is done in collaboration with TNO, UMC and UIPS in the Utrecht Centre for Food Allergy, the University of Applied Sciences (HU) and with the department of Immunobiology, King’s College London.

Gegenereerd op 2018-03-21 15:45:07
Full name
M.W.H.C. Bol-Schoenmakers Contact details
Jeannette Donker-Voetgebouw

Yalelaan 104-106
Room 1.028
The Netherlands

Phone number (direct) +31 30 253 5397
Gegenereerd op 2018-03-21 15:45:07
Last updated 03.12.2017