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Dr. L. (Linda) van der Graaf-van Bloois

Assistant Professor 
Veterinary Medicine
Department Biomolecular Health Sciences
Infectious Diseases & Immunology
Infectious Diseases & Immunology
Androclusgebouw
Yalelaan 1
Kamer W3.12
3584 CL Utrecht

Dr. L. (Linda) van der Graaf-van Bloois

Assistant Professor
Infectious Diseases & Immunology
+31 30 253 4979
l.vandergraaf@uu.nl
Profile Publications Activities Research Teaching Ancillary activities Contact
Profile Publications Activities Research Teaching Ancillary activities Contact
Areas of expertise
Skills
Research areas

Publications

2024

Scholarly publications

Pena-Fernández, N., van der Graaf-van Bloois, L., Duim, B., Zomer, A., Wagenaar, J. A., Ocejo, M., Lavín, J. L., Collantes-Fernández, E., Hurtado, A., & Aduriz, G. (2024). Campylobacter fetus Plasmid Diversity: Comparative Analysis of Fully Sequenced Plasmids and Proposed Classification Scheme. Genome Biology and Evolution, 16(10), Article evae203. https://doi.org/10.1093/gbe/evae203
https://research-portal.uu.nl/ws/files/242745513/evae203.pdf
van der Graaf-van Bloois, L., Zomer, A. L., Duim, B., & Wagenaar, J. A. (2024). Campylobacter fetus subspecies specific PCR assays inferred from comparative genomic analysis for accurate subspecies identification. Journal of Microbiological Methods, 226, Article 107049. https://doi.org/10.1016/j.mimet.2024.107049
https://research-portal.uu.nl/ws/files/241595073/1-s2.0-S0167701224001611-main.pdf
Kannekens-Jager, M. M., Duim, B., der Graaf-van Bloois, L. V., Zomer, A. L., Broekhuizen-Stins, M. J., Boswinkel, M., Wagenaar, J. A., & Broens, E. M. (2024). Methicillin-resistant Staphylococcus aureus outbreak in a Dutch equine referral clinic. Journal of Medical Microbiology, 73(8), Article 001873. https://doi.org/10.1099/jmm.0.001873
Pena-Fernández, N., Ocejo, M., van der Graaf-van Bloois, L., Lavín, J. L., Kortabarria, N., Collantes-Fernández, E., Hurtado, A., & Aduriz, G. (2024). Comparative pangenomic analysis of Campylobacter fetus isolated from Spanish bulls and other mammalian species. Scientific Reports, 14(1), Article 4347. https://doi.org/10.1038/s41598-024-54750-1
https://dspace.library.uu.nl/bitstream/handle/1874/437816/s41598-024-54750-1.pdf?sequence=1

2023

Scholarly publications

van der Graaf-van Bloois, L., Chen, H., Wagenaar, J. A., & Zomer, A. L. (2023). Development of Kaptive databases for Vibrio parahaemolyticus O- and K-antigen genotyping. Microbial genomics, 9(5), Article 001007. https://doi.org/10.1099/mgen.0.001007
https://dspace.library.uu.nl/bitstream/handle/1874/428209/mgen001007.pdf?sequence=1
IJsseldijk, L. L., Begeman, L., Duim, B., Gröne, A., Kik, M. J. L., Klijnstra, M. D., Lakemeyer, J., Leopold, M. F., Munnink, B. B. O., Ten Doeschate, M., van Schalkwijk, L., Zomer, A., der Graaf-van Bloois, L. V., & Broens, E. M. (2023). Harbor Porpoise Deaths Associated with Erysipelothrix rhusiopathiae, the Netherlands, 2021. Emerging Infectious Diseases, 29(4), 835-838. https://doi.org/10.3201/eid2904.221698
https://dspace.library.uu.nl/bitstream/handle/1874/427595/22_1698.pdf?sequence=1
van der Graaf-van Bloois, L., Duim, B., Looft, T., Veldman, K. T., Zomer, A. L., & Wagenaar, J. A. (2023). Antimicrobial resistance in Campylobacter fetus: emergence and genomic evolution. Microbial genomics, 9(3), Article 000934. https://doi.org/10.1099/mgen.0.000934
https://dspace.library.uu.nl/bitstream/handle/1874/427233/mgen000934.pdf?sequence=1
Naing, S. Y., Duim, B., Broens, E. M., Schweitzer, V., Zomer, A., van der Graaf-van Bloois, L., van der Meer, C., Stellingwerff, L., Fluit, A. C., & Wagenaar, J. A. (2023). Molecular Characterization and Clinical Relevance of Taxonomic Reassignment of Staphylococcus schleiferi Subspecies into Two Separate Species, Staphylococcus schleiferi and Staphylococcus coagulans. Microbiology spectrum, 11(2), Article e0467022. https://doi.org/10.1128/spectrum.04670-22
https://dspace.library.uu.nl/bitstream/handle/1874/429484/spectrum.04670-22.pdf?sequence=1
Sips, G. J., van Dijk, M. A. M., van Westreenen, M., van der Graaf-van Bloois, L., Duim, B., & Broens, E. M. (2023). Evidence of cat-to-human transmission of Staphylococcus felis. Journal of Medical Microbiology, 72(2), Article 001661. https://doi.org/10.1099/jmm.0.001661
https://dspace.library.uu.nl/bitstream/handle/1874/426932/jmm001661.pdf?sequence=1

2022

Scholarly publications

Wegener, A., Duim, B., van der Graaf-van Bloois, L., Zomer, A. L., Visser, C. E., Spaninks, M., Timmerman, A. J., Wagenaar, J. A., & Broens, E. M. (2022). Within-Household Transmission and Bacterial Diversity of Staphylococcus pseudintermedius. Pathogens, 11(8), 1-6. Article 850. https://doi.org/10.3390/pathogens11080850
https://dspace.library.uu.nl/bitstream/handle/1874/422837/pathogens_11_00850_v3.pdf?sequence=1
Meijer, E. FJ., Renssen, A. V., Maat, I., Bloois, L. V. D. G., Duim, B., & Broens, E. (2022). Canine Staphylococcus argenteus: Case Report from The Netherlands. Pathogens, 11(2), 1-7. Article 153. https://doi.org/10.3390/pathogens11020153
https://dspace.library.uu.nl/bitstream/handle/1874/416454/pathogens_11_00153.pdf?sequence=1
Naing, S. Y., Hordijk, J., Duim, B., Broens, E., van der Graaf - van Bloois, L., Rossen, J. W. A., Robben, J., Leendertse, M., Wagenaar, J., & Zomer, A. (2022). Genomic Investigation of Two Acinetobacter baumannii Outbreaks in a Veterinary Intensive Care Unit in The Netherlands. Pathogens, 11(2), 1-14. Article 123. https://doi.org/10.3390/pathogens11020123
https://dspace.library.uu.nl/bitstream/handle/1874/416399/pathogens_11_00123_v3.pdf?sequence=1

2021

Scholarly publications

Mederos, A., Galarraga, D., van der Graaf-van Bloois, L., & Buczinski, S. (2021). Performance of bovine genital campylobacteriosis diagnostic tests in bulls from Uruguay: a Bayesian latent class model approach. Tropical Animal Health and Production, 54(1), 1-9. Article 32. https://doi.org/10.1007/s11250-021-03039-w
https://dspace.library.uu.nl/bitstream/handle/1874/414193/Mederos2021_Article_PerformanceOfBovineGenitalCamp.pdf?sequence=1
van der Graaf-van Bloois, L., Wagenaar, J. A., & Zomer, A. L. (2021). RFPlasmid: predicting plasmid sequences from short-read assembly data using machine learning. Microbial genomics, 7(11), 1-11. Article 000683. https://doi.org/10.1099/mgen.0.000683
https://dspace.library.uu.nl/bitstream/handle/1874/413748/mgen000683.pdf?sequence=1
Wegener, A., Broens, E. M., van der Graaf-van Bloois, L., Zomer, A. L., Visser, C. E., van Zeijl, J., van der Meer, C., Kusters, J. G., Friedrich, A. W., Kampinga, G. A., Sips, G. J., Smeets, L., van Kerckhoven, M. E. J., Timmerman, A. J., Wagenaar, J. A., & Duim, B. (2021). Absence of Host-Specific Genes in Canine and Human Staphylococcus pseudintermedius as Inferred from Comparative Genomics. Antibiotics, 10(7), 1-10. Article 854. https://doi.org/10.3390/antibiotics10070854
https://dspace.library.uu.nl/bitstream/handle/1874/412736/antibiotics_10_00854.pdf?sequence=1
Duim, B., van der Graaf-van Bloois, L., Timmerman, A., Wagenaar, J. A., Flipse, J., Wallinga, J., Bloembergen, P., Miller, W. G., & Zomer, A. L. (2021). Complete Genome Sequence of a Clinical Campylobacter Isolate Identical to a Novel Campylobacter Species. Microbiology Resource Announcements, 10(7), 1-3. Article e00721. https://doi.org/10.1128/MRA.00721-20
https://dspace.library.uu.nl/bitstream/handle/1874/411548/Microbiology_Resource_Announcements_2021_Duim_e00721_20.full.pdf?sequence=1
Mughini-Gras, L., Pijnacker, R., Coipan, C., Mulder, A. C., Veludo, A. F., de Rijk, S., van Hoek, A. H. A. M., Buij, R., Muskens, G., Koene, M., Veldman, K., Duim, B., Graaf-van Bloois, L. V. D., van der Weijden, C., Kuiling, S., Verbruggen, A., van der Giessen, J., Opsteegh, M., van der Voort, M., ... Franz, E. (2021). Sources and transmission routes of campylobacteriosis: a combined analysis of genome and exposure data. Journal of Infection, 82(2), 216-226. https://doi.org/10.1016/j.jinf.2020.09.039
https://dspace.library.uu.nl/bitstream/handle/1874/410184/PIIS0163445320307337.pdf?sequence=1

2020

Scholarly publications

van Bloois, L. V. D. G., Wagenaar, J. A., & Zomer, A. L. (2020). RFPlasmid: Predicting plasmid sequences from short read assembly data using machine learning. (pp. 1-17). bioRxiv. https://doi.org/10.1101/2020.07.31.230631
https://dspace.library.uu.nl/bitstream/handle/1874/419991/2020.07.31.230631v2.full.pdf?sequence=1
Flipse, J., Duim, B., Wallinga, J. A., de Wijkerslooth, L. R. H., Graaf-van Bloois, L. V. D., Timmerman, A. J., Zomer, A. L., Veldman, K. T., Wagenaar, J. A., & Bloembergen, P. (2020). A Case of Persistent Diarrhea in a Man with the Molecular Detection of Various Campylobacter species and the First Isolation of candidatus Campylobacter infans. Pathogens, 9(12), Article 1003. https://doi.org/10.3390/pathogens9121003
https://dspace.library.uu.nl/bitstream/handle/1874/410183/pathogens_09_01003.pdf?sequence=1
Aydin, F., Abay, M., Atasever, A., Çakir Bayram, L., Karakaya, E., Abay, S., Ekebaş, G., Müştak, H. K., Gümüşsoy, K. S., van der GRAAF-VAN BLOOIS, L., & Diker, K. S. (2020). Ovine abortion associated with campylobacter fetus subsp. Fetus st2 in turkey. Kafkas Universitesi Veteriner Fakultesi Dergisi, 26(4), 557-562. https://doi.org/10.9775/kvfd.2019.23769
https://dspace.library.uu.nl/bitstream/handle/1874/409361/pdf_KVFD_2698.pdf?sequence=1
Mulder, A. C., Franz, E., de Rijk, S., Versluis, M. A. J., Coipan, C., Buij, R., Müskens, G., Koene, M., Pijnacker, R., Duim, B., Bloois, L. V. D. G. V., Veldman, K., Wagenaar, J. A., Zomer, A. L., Schets, F. M., Blaak, H., & Mughini-Gras, L. (2020). Tracing the animal sources of surface water contamination with Campylobacter jejuni and Campylobacter coli. Water Research, 187, Article 116421. https://doi.org/10.1016/j.watres.2020.116421
https://dspace.library.uu.nl/bitstream/handle/1874/409360/1_s2.0_S0043135420309568_main.pdf?sequence=1
Castellanos, L. R., van der Graaf-van Bloois, L., Donado-Godoy, P., Veldman, K., Duarte, F., Acuña, M. T., Jarquín, C., Weill, F.-X., Mevius, D. J., Wagenaar, J. A., Hordijk, J., & Zomer, A. L. (2020). Antimicrobial Resistance in Salmonella enterica Serovar Paratyphi B Variant Java in Poultry from Europe and Latin America. Emerging Infectious Diseases, 26(6), 1164-1173. https://doi.org/10.3201/eid2606.191121
https://dspace.library.uu.nl/bitstream/handle/1874/408448/19_1121.pdf?sequence=1

2019

Scholarly publications

Emele, M. F., Karg, M., Hotzel, H., van der Graaf - van Bloois, L., Groß, U., Bader, O., & Zautner, A. E. (2019). Differentiation of Campylobacter fetus Subspecies by Proteotyping. European journal of microbiology & immunology, 9(2), 62-71. https://doi.org/10.1556/1886.2019.00006
https://dspace.library.uu.nl/bitstream/handle/1874/386565/1886.2019.00006.pdf?sequence=1
Castellanos, L. R., van der Graaf-van Bloois, L., Donado-Godoy, P., Mevius, D. J., Wagenaar, J. A., Hordijk, J., & Zomer, A. (2019). Phylogenomic Investigation of IncI1-Iγ Plasmids Harboring blaCMY-2 and blaSHV-12 in Salmonella enterica and Escherichia coli in Multiple Countries. Antimicrobial Agents and Chemotherapy, 63(7), Article e02546-18. https://doi.org/10.1128/AAC.02546-18
https://dspace.library.uu.nl/bitstream/handle/1874/389994/Antimicrobial_Agents_and_Chemotherapy_2019_Castellanos_e02546_18.full.pdf?sequence=1
Wegener, A. C. H., Broens, E. M., Zomer, A. L., van Bloois, L., Timmerman, A. J., Wagenaar, J. A., & Duim, B. (2019). Comparison and dynamics of resistance gene content in canine and human Staphylococcus pseudintermedius. Poster session presented at KNVM Spring meeting.

2018

Scholarly publications

Castellanos, L. R., van der Graaf-van Bloois, L., Donado-Godoy, P., León, M., Clavijo, V., Arévalo, A., Bernal, J. F., Mevius, D. J., Wagenaar, J. A., Zomer, A., & Hordijk, J. (2018). Genomic Characterization of Extended-Spectrum Cephalosporin-Resistant in the Colombian Poultry Chain. Frontiers in Microbiology, 9, Article 2431. https://doi.org/10.3389/fmicb.2018.02431
https://dspace.library.uu.nl/bitstream/handle/1874/397045/castellanos.pdf?sequence=1
Gilbert, M. J., Duim, B., van der Graaf-van Bloois, L., Wagenaar, J. A., & Zomer, A. L. (2018). Homologous Recombination between Genetically Divergent Campylobacter fetus Lineages Supports Host-Associated Speciation. Genome Biology and Evolution, 10(3), 716-722. https://doi.org/10.1093/gbe/evy048
https://dspace.library.uu.nl/bitstream/handle/1874/372784/gilbert.pdf?sequence=1

2017

Professional publications

van der Graaf - van Bloois, L. (2017). Diagnostische test Campylobacter fetus moet veranderen. Tijdschrift voor Diergeneeskunde, 2017(02).

2016

Scholarly publications

van Bloois, L. (2016). Molecular characterization and differentiation of Campylobacter fetus subspecies. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/342332/vBloois.pdf?sequence=1
van der Graaf-van Bloois, L., Duim, B., Miller, W. G., Forbes, K. J., Wagenaar, J. A., & Zomer, A. (2016). Whole genome sequence analysis indicates recent diversification of mammal-associated Campylobacter fetus and implicates a genetic factor associated with H2S production. BMC Genomics, 17, Article 713. https://doi.org/10.1186/s12864-016-3058-7
https://dspace.library.uu.nl/bitstream/handle/1874/345974/Whole.pdf?sequence=1
Gilbert, M. J., Miller, W. G., Yee, E., Zomer, A. L., van der Graaf-van Bloois, L., Fitzgerald, C., Forbes, K. J., Méric, G., Sheppard, S. K., Wagenaar, J. A., & Duim, B. (2016). Comparative Genomics of Campylobacter fetus from Reptiles and Mammals Reveals Divergent Evolution in Host-Associated Lineages. Genome Biology and Evolution, 8(6), 2006-2019. https://doi.org/10.1093/gbe/evw146
https://dspace.library.uu.nl/bitstream/handle/1874/345465/Comparative.pdf?sequence=1
Graaf-van Bloois, L. V. D., Miller, W. G., Yee, E., Gorkiewicz, G., Forbes, K. J., Zomer, A. L., Wagenaar, J. A., & Duim, B. (2016). Campylobacter fetus Subspecies Contain Conserved Type IV Secretion Systems on Multiple Genomic Islands and Plasmids. PLoS One, 11(4), Article e0152832. https://doi.org/10.1371/journal.pone.0152832
https://dspace.library.uu.nl/bitstream/handle/1874/345444/Campylobacter.PDF?sequence=1

2014

Scholarly publications

van der Graaf-van Bloois, L., Miller, W. G., Yee, E., Bono, J. L., Rijnsburger, M., Campero, C., Wagenaar, J. A., & Duim, B. (2014). First Closed Genome Sequence of Campylobacter fetus subsp. venerealis bv. intermedius. Genome Announcements, 2(1), Article e01246-13. https://doi.org/10.1128/genomeA.01246-13
https://dspace.library.uu.nl/bitstream/handle/1874/308956/Bloois.pdf?sequence=1
van der Graaf-van Bloois, L., Miller, W. G., Yee, E., Rijnsburger, M., Wagenaar, J. A., & Duim, B. (2014). Inconsistency of Phenotypic and Genomic Characteristics of Campylobacter fetus Subspecies Requires Reevaluation of Current Diagnostics. Journal of Clinical Microbiology, 52(12), 4183-4188. https://doi.org/10.1128/JCM.01837-14
https://dspace.library.uu.nl/bitstream/handle/1874/308952/8.pdf?sequence=1

2013

Scholarly publications

Louwen, R., Horst-Kreft, D., de Boer, A. G., van der Graaf, L., de Knegt, G., Hamersma, M., Heikema, A. P., Timms, A. R., Jacobs, B. C., Wagenaar, J. A., Endtz, H. P., van der Oost, J., Wells, J. M., Nieuwenhuis, E. E. S., van Vliet, A. H., Willemsen, P. T., van Baarlen, P., & van Belkum, A. (2013). A novel link between Camplyobacter jejuni bacteriophage defence, virulence and Guillain-Barré sundrome. European Journal of Clinical Microbiology & Infectious Diseases, 32(2), 207-26. https://doi.org/10.1007/s10096-012-1733-4
https://dspace.library.uu.nl/bitstream/handle/1874/277018/10.1007_s10096-012-1733-4.pdf?sequence=2
van der Graaf-van Bloois, L., van Bergen, M. A. P., van der Wal, F. J., de Boer, A. G., Duim, B., Schmidt, T., & Wagenaar, J. A. (2013). Evaluation of molecular assays for identification Campylobacter fetus species and subspecies and development of a C. fetus specific real-time PCR assay. Journal of Microbiological Methods, 95, 93-97. https://doi.org/10.1016/j.mimet.2013.06.005
https://dspace.library.uu.nl/bitstream/handle/1874/287267/Graaf%2520et%2520al%25202013.pdf?sequence=1

2011

Scholarly publications

Spence, R. P., Bruce, I. R., McFadden, A. M. J., Hill, F. I., Tisdall, D., Humphrey, S., van der Graaf-van Bloois, L., van Bergen, M. A. P., & Wagenaar, J. A. (2011). Cross-reaction of a Campylobacter fetus subspecies venerealis real-time PCR. Veterinary Record. https://doi.org/10.1136/vr.c5264
https://dspace.library.uu.nl/bitstream/handle/1874/234191/Cross_reaction_of_a_Campylobacter_fetus_subspecies.pdf?sequence=2

2009

Scholarly publications

Gaasbeek, E. J., van der Wal, F. J., van Putten, J. P. M., Boer, P., van der Graaf-van Bloois, L., de Boer, A. G., Vermaning, B. J., & Wagenaar, J. A. (2009). Functional characterization of excision repair and RecA-dependent recombinational DNA repair in Campylobacter jejuni. Journal of Bacteriology, 191(12), 3785-3793. https://doi.org/10.1128/JB.01817-08
https://dspace.library.uu.nl/bitstream/handle/1874/37510/Gaasbeek%25201%2520et%2520al%25202009%2520.pdf?sequence=1
Gaasbeek, E. J., Wagenaar, J. A., Guilhabert, M. R., Wösten, M. M. S. M., van Putten, J. P. M., van der Graaf-van Bloois, L., Parker, C. T., & van der Wal, F. J. (2009). A DNase encoded by integrated element CJIE1 inhibits natural transformation of Campylobacter jejuni. Journal of Bacteriology, 191(7), 2296-2306. https://doi.org/10.1128/JB.01430-08
https://dspace.library.uu.nl/bitstream/handle/1874/37479/Gaasbeek%2520et%2520al%25202009.pdf?sequence=1

2007

Scholarly publications

Velkers, F. C., van der Graaf - van Bloois, L., Wagenaar, J., Westendorp, S. T., Bergen, M. A. P., & Landman, W. J. M. (2007). Enterococcus durans-associated endocarditis in broilers. In Proceedings of the XV World Veterinary Poultry Association Congress (WVPC 2007), Beijing, China  (pp. 252)
Kaszanyitzky, E. J., Janosi, S., Somogyi, P., van der Graaf-van Bloois, L., van Duijkeren, E., & Wagenaar, J. A. (2007). MRSA transmission between cows and humans. Emerging Infectious Diseases, 13, 630-632. https://doi.org/10.3201/eid1304.060833
https://dspace.library.uu.nl/bitstream/handle/1874/407085/06_0833.pdf?sequence=1

2006

Scholarly publications

van Bergen, M. A. P., van der Graaf-van Bloois, L., Visser, I. J. R., van Putten, J. P. M., & Wagenaar, J. A. (2006). Molecular epidemiology of Campylobacter fetus subsp. fetus on bovine artificial insemination stations using pulsed field gel electrophoresis. Veterinary Microbiology, 112(1), 65-71. https://doi.org/10.1016/j.vetmic.2005.09.009
Ho, H., Lipman, L. J. A., van der Graaf-van Bloois, L., van Bergen, M., & Gaastra, W. (2006). Potential routes of acquisition of Arcobacter species by piglets. Veterinary Microbiology, 114(1-2), 123-133.

2005

Scholarly publications

van Bergen, M. A., Dingle, K. E., Maiden, M. C., Newell, D. G., van der Graaf-van Bloois, L., van Putten, J. P., & Wagenaar, J. A. (2005). Clonal Nature of Campylobacter fetus as Defined by Multilocus Sequence Typing. Journal of Clinical Microbiology, 43(12), 5888-5898. https://doi.org/10.1128/JCM.43.12.5888-5898.2005
van Bergen, M. A., Simons, G., van der Graaf-van Bloois, L., van Putten, J. P. M., Rombout, J., Wesley, I., & Wagenaar, J. A. (2005). Amplified fragment length polymorphism based identification of genetic markers and novel PCR assay for differentiation of Campylobacter fetus subspecies. Journal of Medical Microbiology, 54(12), 1217-1224. https://doi.org/10.1099/jmm.0.46186-0
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