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Dr. L.C. (Louis) Penning

Associate Professor 
Veterinary Medicine
Department Clinical Sciences
Internal Medicine of Companion Animals
Inwendige Ziekten
Inwendige Ziekten
Prof. dr. H. Jakobgebouw
Yalelaan 108110
Kamer 2.002
3584 CM Utrecht

Dr. L.C. (Louis) Penning

Associate Professor
Inwendige Ziekten
Profile Publications Activities Prizes Research Teaching Contact
Profile Publications Activities Prizes Research Teaching Contact
Research areas

Publications

2023

Scholarly publications

van Doorn, D., van Millingen-Kraan, R., van Baal, J., van der hee, B., van den Boom, R., Pellikaan, W. F., Spee, B., & Penning, L. (2023). Updates on equine organoids: Developing equine liver organoids for nutritional studies and (metabolic) disease modeling.
Penning, L. C., & van den Boom, R. (2023). Companion animal organoid technology to advance veterinary regenerative medicine. Frontiers in Veterinary Science, 10, 1-12. [1032835]. https://doi.org/10.3389/fvets.2023.1032835
van Blokland-Post, K., Weber, M. F., van Wolferen, M. E., Penning, L. C., van Sluijs, F. J., & Kummeling, A. (2023). Prediction of outcome after ligation or thin film banding of extrahepatic shunts, based on plasma albumin concentration and hematologic expression of 8 target genes in 85 dogs. Journal of Veterinary Internal Medicine, 37(2), 537-549. https://doi.org/10.1111/jvim.16680
Corbee, R. J., van Everdingen, D. L., Kooistra, H. S., & Penning, L. C. (2023). Fibroblast growth factor-21 (FGF21) analogs as possible treatment options for diabetes mellitus in veterinary patients. Frontiers in Veterinary Science, 9, 1-8. [1086987]. https://doi.org/10.3389/fvets.2022.1086987

2022

Scholarly publications

Krüger, M., Samsom, R-A., Oosterhoff, L., van Wolferen, M., Kooistra, H., Geijsen, N., Penning, L., Kock, L. M., Sainz-Arnal, P., Baptista, P. M., & Spee, B. (2022). High level of polarized engraftment of porcine intrahepatic cholangiocyte organoids in decellularized liver scaffolds. Journal of Cellular and Molecular Medicine, 26(19), 4949-4958. https://doi.org/10.1111/jcmm.17510
Wang, Z., Faria, J., van der Laan, L. J. W., Penning, L. C., Masereeuw, R., & Spee, B. (2022). Human Cholangiocytes Form a Polarized and Functional Bile Duct on Hollow Fiber Membranes. Frontiers in Bioengineering and Biotechnology, 10, 1-10. [868857]. https://doi.org/10.3389/fbioe.2022.868857

2021

Scholarly publications

Corbee, R. J., & Penning, L. C. (2021). COMMD1 Exemplifies the Power of Inbred Dogs to Dissect Genetic Causes of Rare Copper-Related Disorders. Animals, 11(3), 1-14. [601]. https://doi.org/10.3390/ani11030601

2020

Scholarly publications

Molenaar, M. R., Penning, L. C., & Helms, J. B. (2020). Playing Jekyll and Hyde-The Dual Role of Lipids in Fatty Liver Disease. Cells, 9(10), [2244]. https://doi.org/10.3390/cells9102244
Wang, Z., Faria, J., Penning, L., Masereeuw, R., & Spee, B. (2020). Tissue Engineered Bile Ducts for Disease Modeling and Therapy. Tissue engineering. Part C, Methods. https://doi.org/10.1089/ten.TEC.2020.0283
Ribitsch, I., Baptista, P. M., Lange-Consiglio, A., Melotti, L., Patruno, M., Jenner, F., Schnabl-Feichter, E., Dutton, L. C., Connolly, D. J., van Steenbeek, F. G., Dudhia, J., & Penning, L. C. (2020). Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do. Frontiers in Bioengineering and Biotechnology, 8, [972]. https://doi.org/10.3389/fbioe.2020.00972
Ye, S., Boeter, J. W. B., Mihajlovic, M., van Steenbeek, F. G., van Wolferen, M. E., Oosterhoff, L. A., Marsee, A., Caiazzo, M., van der Laan, L. J. W., Penning, L. C., Vermonden, T., Spee, B., & Schneeberger, K. (2020). A Chemically Defined Hydrogel for Human Liver Organoid Culture. Advanced Functional Materials, 30(48), [2000893]. https://doi.org/10.1002/adfm.202000893
Valtolina, C., Robben, J. H., van Wolferen, M. E., Kruitwagen, H. S., Corbee, R. J., Favier, R. P., & Penning, L. C. (2020). Gene expressions of de novo hepatic lipogenesis in feline hepatic lipidosis. Journal of Feline Medicine and Surgery, 22(6), 500-505. https://doi.org/10.1177/1098612X19857853
Li, Y., Qu, C., Spee, B., Zhang, R., Penning, L. C., de Man, R. A., Peppelenbosch, M. P., Fieten, H., & Pan, Q. (2020). Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection. Irish Veterinary Journal, 73(1), [6]. https://doi.org/10.1186/s13620-020-00158-y
Kramer, N., Pratscher, B., Meneses, A. M. C., Tschulenk, W., Walter, I., Swoboda, A., Kruitwagen, H. S., Schneeberger, K., Penning, L. C., Spee, B., Kieslinger, M., Brandt, S., & Burgener, I. A. (2020). Generation of Differentiating and Long-Living Intestinal Organoids Reflecting the Cellular Diversity of Canine Intestine. Cells, 9(4), [822]. https://doi.org/10.3390/cells9040822
Kruitwagen, H. S., Oosterhoff, L. A., van Wolferen, M. E., Chen, C., Nantasanti Assawarachan, S., Schneeberger, K., Kummeling, A., van Straten, G., Akkerdaas, I. C., Vinke, C. R., van Steenbeek, F. G., van Bruggen, L. W. L., Wolfswinkel, J., Grinwis, G. C. M., Fuchs, S. A., Gehart, H., Geijsen, N., Vries, R. G., Clevers, H., ... Spee, B. (2020). Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a COMMD1-Deficient Dog Model of Metabolic Liver Disease. Cells, 9(2), 1-16. [410]. https://doi.org/10.3390/cells9020410
Haaker, M. W., Kruitwagen, H. S., Vaandrager, A. B., Houweling, M., Penning, L. C., Molenaar, M. R., van Wolferen, M. E., Oosterhoff, L. A., Spee, B., & Helms, J. B. (2020). Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system. Journal of Veterinary Internal Medicine, 34(1), 132-138. https://doi.org/10.1111/jvim.15670

2019

Scholarly publications

Schneeberger, K., Sánchez-Romero, N., Ye, S., van Steenbeek, F. G., Oosterhoff, L. A., Pla Palacin, I., Chen, C., van Wolferen, M. E., van Tienderen, G., Lieshout, R., Colemonts-Vroninks, H., Schene, I., Hoekstra, R., Verstegen, M. M. A., van der Laan, L. J. W., Penning, L. C., Fuchs, S. A., Clevers, H., De Kock, J., ... Spee, B. (Accepted/In press). Large-scale Production of LGR5-positive Bipotential Human Liver Stem Cells. Hepatology. https://doi.org/10.1002/hep.31037
Ye, S., Boeter, J. W. B., Penning, L. C., Spee, B., & Schneeberger, K. (2019). Hydrogels for Liver Tissue Engineering. Bioengineering (Basel, Switzerland), 6(3), [59]. https://doi.org/10.3390/bioengineering6030059
Oosterhoff, L. A., Kruitwagen, H. S., van Wolferen, M. E., van Balkom, B. W. M., Mokry, M., Lansu, N., van den Dungen, N. A. M., Penning, L. C., Spanjersberg, T. C. F., de Graaf, J. W., Veenendaal, T., Zomerdijk, F., Fledderus, J. O., Spee, B., & van Steenbeek, F. G. (2019). Characterization of Endothelial and Smooth Muscle Cells From Different Canine Vessels. Frontiers in Physiology, 10, [101]. https://doi.org/10.3389/fphys.2019.00101
Sakai, M., Spee, B., Grinwis, G. C. M., Penning, L. C., van Wolferen, M. E., van der Laan, L. J. W., & Fieten, H. (2019). Association of circulating microRNA-122 and microRNA-29a with stage of fibrosis and progression of chronic hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine, 33(1), 151-157. https://doi.org/10.1111/jvim.15366
Valtolina, C., Robben, J. H., Favier, R. P., Rothuizen, J., Grinwis, G. C., Schotanus, B. A., & Penning, L. C. (2019). Immunohistochemical characterisation of the hepatic stem cell niche in feline hepatic lipidosis: a preliminary morphological study. Journal of Feline Medicine and Surgery, 21(2), 165-172. https://doi.org/10.1177/1098612X18765922

2018

Scholarly publications

Kruitwagen, H. S., Westendorp, B., Viebahn, C. S., Post, K., van Wolferen, M. E., Oosterhoff, L. A., Egan, D. A., Delabar, J-M., Toussaint, M. J., Schotanus, B. A., de Bruin, A., Rothuizen, J., Penning, L. C., & Spee, B. (2018). DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells. Stem Cells and Development, 27(2), 133-146. https://doi.org/10.1089/scd.2017.0139
Vastenhout, N., van Rijn, S. J., Riemers, F. M., Tryfonidou, M. A., Meij, B. P., & Penning, L. C. (2018). The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas. Veterinary Journal, 240, 19-21. https://doi.org/10.1016/j.tvjl.2018.08.012
Chen, C., Pla-Palacín, I., Baptista, P. M., Shang, P., Oosterhoff, L. A., van Wolferen, M. E., Penning, L. C., Geijsen, N., & Spee, B. (2018). Hepatocyte-like cells generated by direct reprogramming from murine somatic cells can repopulate decellularized livers. Biotechnology and Bioengineering, 115(11), 2807-2816. https://doi.org/10.1002/bit.26784
Chen, C., Jochems, P., Salz, L., Schneeberger, K., Penning, L. C., van de Graaf, S. F. J., Beuers, U., Clevers, H., Geijsen, N., Masereeuw, R., & Spee, B. (2018). Bioengineered bile ducts recapitulate key cholangiocyte functions. Biofabrication, 10(3), [034103]. https://doi.org/10.1088/1758-5090/aac8fd
Van den Bossche, L., van Steenbeek, F. G., Weber, M. F., Spee, B., Penning, L. C., van Sluijs, F. J., Zomerdijk, F., Groot Koerkamp, M. J. A., Rothuizen, J., Burgener, I. A., & Kummeling, A. (2018). Genome-wide based model predicting recovery from portosystemic shunting after liver shunt attenuation in dogs. Journal of Veterinary Internal Medicine, 32(4), 1343-1352. https://doi.org/10.1111/jvim.15140
Otte, C. M., Valtolina, C., Vreman, S., Hubers, S., van Wolferen, M. E., Favier, R. P., Rothuizen, J., & Penning, L. C. (2018). Immunohistochemical evaluation of the activation of hepatic progenitor cells and their niche in feline lymphocytic cholangitis. Journal of Feline Medicine and Surgery, 20(1), 30-37. https://doi.org/10.1177/1098612X17699723
Hennink, I., van Leeuwen, M. W., Penning, L. C., & Piek, C. J. (2018). Increased number of tissue factor protein expressing thrombocytes in canine idiopathic immune mediated hemolytic anemia. Veterinary Immunology and Immunopathology, 196, 22-29. https://doi.org/10.1016/j.vetimm.2017.12.009
Teunissen, M., M Riemers, F., van Leenen, D., J A Groot Koerkamp, M., P Meij, B., Alblas, J., C Penning, L., Miranda-Bedate, A., & A Tryfonidou, M. (2018). Growth Plate Expression profiling: Large and Small Breed Dogs Provide New Insights in Endochondral Bone Formation. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.23647

2017

Scholarly publications

Otte, C. M., Penning, L. C., & Rothuizen, J. (2017). Feline biliary tree and gallbladder disease: Aetiology, diagnosis and treatment. Journal of Feline Medicine and Surgery, 19(5), 514-528. https://doi.org/10.1177/1098612X17706465
Kruitwagen, H. S., Oosterhoff, L. A., Vernooij, I. G. W. H., Schrall, I. M., van Wolferen, M. E., Bannink, F., Roesch, C., van Uden, L., Molenaar, M. R., Helms, J. B., Grinwis, G. C. M., Verstegen, M. M. A., van der Laan, L. J. W., Huch, M., Geijsen, N., Vries, R. R. G., Clevers, H., Rothuizen, J., Schotanus, B. A., ... Spee, B. (2017). Long-Term Adult Feline Liver Organoid Cultures for Disease Modeling of Hepatic Steatosis. Stem Cell Reports, 8(4), 822-830. https://doi.org/10.1016/j.stemcr.2017.02.015
van Sprundel, R. G. H. M., van den Ingh, T. S., Schotanus, B. A., van Wolferen, M. E., Penning, L. C., Rothuizen, J., & Spee, B. (2017). Cellular characteristics of keratin 19-positive canine hepatocellular tumours explain its aggressive behaviour. AERA Open, 4(1), [e000212]. https://doi.org/10.1136/vetreco-2016-000212
Van den Bossche, L., Schoonenberg, V. A. C., Burgener, I. A., Penning, L. C., Schrall, I. M., Kruitwagen, H. S., van Wolferen, M. E., Grinwis, G. C. M., Kummeling, A., Rothuizen, J., van Velzen, J. F., Stathonikos, N., Molenaar, M. R., Helms, B. J., Brouwers, J. F. H. M., Spee, B., & van Steenbeek, F. G. (2017). Aberrant hepatic lipid storage and metabolism in canine portosystemic shunts. PLoS One, 12(10), [e0186491]. https://doi.org/10.1371/journal.pone.0186491
Dirksen, K., Burgener, I. A., Rothuizen, J., van den Ingh, T. S. G. A. M., Penning, L. C., Spee, B., & Fieten, H. (2017). Sensitivity and Specificity of Plasma ALT, ALP, and Bile Acids for Hepatitis in Labrador Retrievers. Journal of Veterinary Internal Medicine, 31, 1017–1027. https://doi.org/10.1111/jvim.14716
Dirksen, K., Spee, B., Penning, L. C., van den Ingh, T. S. G. A. M., Burgener, I. A., Watson, A. L., Groot Koerkamp, M., Rothuizen, J., van Steenbeek, F. G., & Fieten, H. (2017). Gene expression patterns in the progression of canine copper-associated chronic hepatitis. PLoS One, 12(5), e0176826. https://doi.org/10.1371/journal.pone.0176826

2016

Scholarly publications

Meneses, A. M. C., Schneeberger, K., Kruitwagen, H. S., Penning, L. C., van Steenbeek, F. G., Burgener, I. A., & Spee, B. (2016). Intestinal Organoids-Current and Future Applications. Veterinary Sciences, 3(4). https://doi.org/10.3390/vetsci3040031
Meneses, A., Schneeberger, K., Kruitwagen, H., Penning, L., van Steenbeek, F., Burgener, I., & Spee, B. (2016). Intestinal Organoids—Current and Future Applications. Veterinary Sciences, 3(4), 31. https://doi.org/10.3390/vetsci3040031
van Rijn, S., Galac, S., Tryfonidou, M. A., Hesselink, J. W., Penning, L. C., Kooistra, H. S., & Meij, B. P. (2016). The Influence of Pituitary Size on Outcome After Transsphenoidal Hypophysectomy in a Large Cohort of Dogs with Pituitary-Dependent Hypercortisolism. Journal of Veterinary Internal Medicine, 30(4), 989-995. https://doi.org/10.1111/jvim.14367
Dirksen, K., Roelen, Y. S., van Wolferen, M. E., Kruitwagen, H. S., Penning, L. C., Burgener, I. A., Spee, B., & Fieten, H. (2016). Erythrocyte copper chaperone for superoxide dismutase and superoxide dismutase as biomarkers for hepatic copper concentrations in Labrador retrievers. Veterinary Journal, 218, 1-6. https://doi.org/10.1016/j.tvjl.2016.10.007
Dirksen, K., Verzijl, T., Grinwis, G. C., Favier, R. P., Penning, L. C., Burgener, I. A., van der Laan, L. J., Fieten, H., & Spee, B. (2016). Use of Serum MicroRNAs as Biomarker for Hepatobiliary Diseases in Dogs. Journal of Veterinary Internal Medicine, 30(6), 1816-1823. https://doi.org/10.1111/jvim.14602
Nantasanti, S., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2016). Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals. Stem cells translational medicine, 5(3), 325–330. https://doi.org/10.5966/sctm.2015-0152
Malagola, E., Teunissen, M., van der Laan, L. J. W., Verstegen, M., Schotanus, B. A., van Steenbeek, F. G., Penning, L. C., van Wolferen, M. E., Tryfonidou, M. A., & Spee, B. (2016). Characterization and comparison of canine multipotent stromal cells derived from liver and bone marrow. Stem Cells and Development, 35(2). https://doi.org/10.1089/scd.2015.0125

2015

Scholarly publications

Stassen, Q. E. M., Riemers, F. M., Reijmerink, H., Leegwater, P. A. J., & Penning, L. C. (2015). Reference genes for reverse transcription quantitative PCR in canine brain tissue. BMC Research Notes, 8(1), [761]. https://doi.org/10.1186/s13104-015-1628-4
Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports [E], 5(5), 895-907. https://doi.org/10.1016/j.stemcr.2015.09.002
van Rijn, S. J., Hanson, J. M., Zierikzee, D., Kooistra, H. S., Penning, L. C., Tryfonidou, M. A., & Meij, B. P. (2015). The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas. Journal of Veterinary Internal Medicine, 29(3), 869-876. https://doi.org/10.1111/jvim.12601
van Rijn, S. J., Pouwer, M. G., Tryfonidou, M. A., Grinwis, G. C. M., van der Bend, J. E. E., Beukers, P. E. P. F., Vastenhout, N., Drouin, J., Penning, L. C., & Meij, B. P. (2015). Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. Veterinary Journal, 204(3), 315-321. https://doi.org/10.1016/j.tvjl.2015.04.014
van Dongen, A. M., Heuving, S. M., Tryfonidou, M. A., van Steenbeek, F. G., Rothuizen, J., & Penning, L. C. (2015). Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt. Veterinary Journal, 204(2), 226-228. https://doi.org/10.1016/j.tvjl.2015.03.008
Favier, R. P., Spee, B., Fieten, H., van den Ingh, T. S. G. A. M., Schotanus, B. A., Brinkhof, B., Rothuizen, J., & Penning, L. C. (2015). Aberrant expression of copper associated genes after copper accumulation in COMMD1-deficient dogs. Journal of Trace Elements in Medicine and Biology, 29, 347-53. https://doi.org/10.1016/j.jtemb.2014.06.007

2014

Scholarly publications

Bach, F. C., Rutten, K., Hendriks, K., Riemers, F. M., Cornelissen, P., de Bruin, A., Arkesteijn, G. J., Wubbolts, R., Horton, W. A., Penning, L. C., & Tryfonidou, M. A. (2014). The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes. Journal of Cellular Physiology, 229(12), 1999-2014. https://doi.org/10.1002/jcp.24658
van der Laan, L. J. W., de Ruiter, P. E., van Gils, I. M., Fieten, H., Spee, B., Pan, Q., Rothuizen, J., & Penning, L. C. (2014). Canine hepacivirus and idiopathic hepatitis in dogs from a Dutch cohort. Journal of Viral Hepatitis, 21(12), 894-896. https://doi.org/10.1111/jvh.12268
Kruitwagen, H. S., Spee, B., Viebahn, C. S., Venema, H. B., Penning, L. C., Grinwis, G. C. M., Favier, R. P., van den Ingh, T. S. G. A. M., Rothuizen, J., & Schotanus, B. A. (2014). The canine hepatic progenitor cell niche: molecular characterisation in health and disease. Veterinary Journal, 201(3), 345–352. https://doi.org/10.1016/j.tvjl.2014.05.024
Schotanus, B. A., Kruitwagen, H. S., van den Ingh, T., van Wolferen, M. E., Rothuizen, J., Penning, L. C., & Spee, B. (2014). Enhanced Wnt/ß-catenin and Notch signalling in the activated canine hepatic progenitor cell niche. BMC Veterinary Research, 10, [10:309 ]. https://doi.org/10.1186/s12917-014-0309-1
Otte, C. M., Rothuizen, J., Favier, R. P., Penning, L. C., & Vreman, S. (2014). A morphological and immunohistochemical study of the effects of prednisolone or ursodeoxycholic acid on liver histology in feline lymphocytic cholangitis. Journal of Feline Medicine and Surgery, 16(10), 796-804. https://doi.org/10.1177/1098612X14520811
van Rijn, S. J., Riemers, F. M., van den Heuvel, D., Wolfswinkel, J., Hofland, L., Meij, B. P., & Penning, L. C. (2014). Expression stability of reference genes for quantitative RT-PCR of healthy and diseased pituitary tissue samples varies between humans, mice, and dogs. Molecular Neurobiology, 49(2), 893-899. https://doi.org/10.1007/s12035-013-8567-7
Boerkamp, K. M., van Steenbeek, F. G., Penning, L. C., Groot Koerkamp, M. J. A., van Leenen, D., Vos-Loohuis, M., Grinwis, G. C. M., & Rutteman, G. R. (2014). The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression. PLoS One, 9(6), [e98258]. https://doi.org/10.1371/journal.pone.0098258
Fieten, H., Penning, L. C., Leegwater, P. A. J., & Rothuizen, J. (2014). New canine models of copper toxicosis: diagnosis, treatment, and genetics. Annals of the New York Academy of Sciences, 1314, 42-48. https://doi.org/10.1111/nyas.12442
Bach, F. C., Willems, N., Penning, L. C., Ito, K., Meij, B. P., & Tryfonidou, M. A. (2014). Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC Veterinary Research, 10, [10:3 ]. https://doi.org/10.1186/1746-6148-10-3

Other output

Schotanus, B. A., Nantasanti, S., Huch, M., Oosterhoff, L., Fieten, H., Kruitwagen, H. S., van Wolferen, M., Grinwis, G. C. M., Wubbolts, R., Favier, R. P., Penning, L. C., Vries, R. G. J., Clevers, H., Rothuizen, J., & Spee, B. (2014). Wnt AND NOTCH REGULATE PROLIFERATION, MIGRATION AND DIFFERENTIATION OF HUMAN HEPATIC PROGENITOR CELLS AND CANINE LIVER ORGANOIDS: Journal of Hepatology. Journal of Hepatology, 60(1, Suppl), S272. [P610]. https://doi.org/10.1016/S0168-8278(14)60772-8

2013

Scholarly publications

van Steenbeek, F. G., Spee, B., Penning, L. C., Kummeling, A., Gils, I. H., Grinwis, G. C. M., van Leenen, D., Holstege, F. C. P., Vos-Loohuis, M., Rothuizen, J., & Leegwater, P. A. J. (2013). Altered subcellular localization of heat shock protein 90 is associated with impaired expression of the aryl hydrocarbon receptor pathway in dogs. PLoS One, 8(3), e57973. https://doi.org/10.1371/journal.pone.0057973
Boerkamp, K. M., van der Kooij, M. A., van Steenbeek, F. G., van Wolferen, M. E., Groot Koerkamp, M. J. A., van Leenen, D., Grinwis, G. C. M., Penning, L. C., Wiemer, E. A., & Rutteman, G. R. (2013). Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog. PLoS One, 8, e71094. https://doi.org/10.1371/journal.pone.0071094
van Steenbeek, F. G., van den Bossche, L., Grinwis, G. C. M., Kummeling, A., Gils, I. H., Koerkamp, M. G., van Leenen, D., Holstege, F. C., Penning, L. C., Rothuizen, J., Leegwater, P. A. J., & Spee, B. (2013). Aberrant gene expression in dogs with portosystemic shunts. PLoS One, 8(2), e57662. https://doi.org/10.1371/journal.pone.0057662
Schotanus, B. A., Penning, L. C., & Spee, B. (2013). Potential of regenerative medicine techniques in canine hepatology. Veterinary Quarterly, 33(4), 207-216. https://doi.org/10.1080/01652176.2013.875240
Otte, C. M. A., Penning, L. C., Rothuizen, J., & Favier, R. P. (2013). Retrospective comparison of prednisolone and ursodeoxycholic acid for the treatment of feline lymphocytic cholangitis. Veterinary Journal, 195(februari 2013), 205-209. https://doi.org/10.1016/j.tvjl.2012.06.020
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Houweling, M., Groot Koerkamp, M. J. A., van Leenen, D., Holstege, F. C. P., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research & Therapy, 15(1), R23. https://doi.org/10.1186/ar4157
Favier, R. P., Poldervaart, J. H., van den Ingh, T. S. G. A. M., Penning, L. C., & Rothuizen, J. (2013). A retrospective study of oral prednisolone treatment in canine chronic hepatitis. Veterinary Quarterly, 33(3), 113-120. https://doi.org/10.1080/01652176.2013.826881
van Rijn, S. J., Tryfonidou, M. A., Hanson, J. M., Penning, L. C., & Meij, B. P. (2013). Stem cells in the canine pituitary gland and in pituitary adenomas. Veterinary Quarterly, 33(4), 217-224. https://doi.org/10.1080/01652176.2013.873961

2012

Scholarly publications

Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Identification of a novel biomolecular target for regeneration of the degenerated canine intervertebral disc. In Proceedings 25th annual symposium of the European Society of Veterinary Neurology (ECVN) and European College of Veterinary Neurology (ESVN) (pp. 14-14)
Kummeling, A., Penning, L. C., Rothuizen, J., Brinkhof, B., Weber, M. F., & van Sluijs, F. J. (2012). Hepatic gene expression and plasma albumin concentration related to outcome after attenuation of a congenital portosystemic shunt in dogs. Veterinary Journal, 191(3), 383-388. https://doi.org/10.1016/j.tvjl.2011.04.022
Smolders, L. A., Onis, D., Riemers, F. M., Penning, L. C., Bergknut, N., Kranenburg, H. C., Hazewinkel, H. A. W., Grinwis, G. C. M., Groot Koerkamp, M., Meij, B. P., & Tryfonidou, M. A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration. In Abstract Book Spineweek 2012 (pp. 256)
van Rijn, S. J., Gremeaux, L., Riemers, F. M., Brinkhof, B., Vankelecom, H., Penning, L. C., & Meij, B. P. (2012). Identification and characterisation of side population cells in the canine pituitary gland. Veterinary Journal, 192(3), 476-482. https://doi.org/10.1016/j.tvjl.2011.06.030
Bergknut, N., Rutges, J. P. H. J., Kranenburg, H-J. C., Smolders, L. A., Hagman, R., Smidt, H-J., Lagerstedt, A-S., Penning, L. C., Voorhout, G., Hazewinkel, H. A. W., Grinwis, G. C. M., Creemers, L. B., Meij, B. P., & Dhert, W. J. A. (2012). The dog as an animal model for intervertebral disc degeneration? Spine, 37(5), 351-358. https://doi.org/10.1097/BRS.0b013e31821e5665
Bustin, S. A., & Penning, L. C. (2012). Improving the analysis of quantitative PCR data in veterinary research. Veterinary Journal, 191(3), 279-281. https://doi.org/10.1016/j.tvjl.2011.06.044
van der Heijden, M., de Vries, M., van Steenbeek, F. G., Favier, R. P., Deijs, M., Brinkhof, B., Rothuizen, J., van der Hoek, L., & Penning, L. C. (2012). Sequence-independent VIDISCA-454 technique to discover new viruses in canine livers. Journal of Virological Methods, 185(1), 152-155. https://doi.org/10.1016/j.jviromet.2012.05.019
Corbee, R. J., Booij-Vrieling, H. E., van de Lest, C. H. A., Penning, L. C., Tryfonidou, M. A., Riemers, F. M., & Hazewinkel, H. A. W. (2012). Inflammation and wound healing in cats with chronic gingivitis/stomatitis after extraction of all premolars and molars were not affected by feeding of two diets with different omega-6/omega-3 polyunsaturated fatty acid ratios. Journal of Animal Physiology and Animal Nutrition, 96(2012), 679-688. https://doi.org/10.1111/j.1439-0396.2011.01195.x
Smolders, L. A., Meij, B. P., Riemers, F. M., Licht, R., Wubbolts, R. W., van den Heuvel, D. J., Grinwis, G. C. M., Vernooij, H., Hazewinkel, H. A. W., Penning, L. C., & Tryfonidou, M. A. (2012). Canonical Wnt Signaling in the Notochordal Cell is Upregulated in Early Intervertebral Disk Degeneration. Journal of Orthopaedic Research, 30(6), 950-957. https://doi.org/10.1002/jor.22000
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration suggests a crucial role of caveolin-1 in notochordal cell preservation. In Proceedings European Veterinary Conference Voorjaarsdagen 2012 (pp. 236-237)
Piek, C. J., Brinkhof, B., Rothuizen, J., Dekker, A., & Penning, L. C. (2012). Leukocyte count affects expression of reference genes in canine whole blood samples. BMC Research Notes, 4, 10.1186/1756-0500-4-36. https://doi.org/10.1186/1756-0500-4-36
Favier, R. P., Spee, B., Schotanus, B. A., van den Ingh, T. S. G. A. M., Fieten, H., Brinkhof, B., Viebahn, C. S., Penning, L. C., & Rothuizen, J. (2012). COMMD1-Deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis. PLoS One, 7(8), e42158. https://doi.org/10.1371/journal.pone.0042158
Bergknut, N., Rutges, J. P. H. J., van Tiel, J., Waarsing, H. J., Meij, B. P., Hazewinkel, H. A. W., Penning, L. C., Lagerstedt, A. S., Hagman, R., Creemers, L. B., & Dhert, W. J. A. (2012). Intervertebral disc regeneration in a rabbit annular puncture model using BMP-7 and Marimastat. In Proceedings Annual Congress European Society and College of Veterinary Neurology (ECVS & ECVN)
Otte, C., Gutiérrez, O. P., Favier, R. P., Rothuizen, J., & Penning, L. C. (2012). Detection of bacterial DNA in bile of cats with lymphocytic cholangitis. Veterinary Microbiology, 156(1-2), 217-221. https://doi.org/10.1016/j.vetmic.2011.10.023
Booij-Vrieling, H. E., de Vries, T. J., Schoenmaker, T., Tryfonidou, M. A., Penning, L. C., Hazewinkel, H. A. W., & Everts, V. (2012). Osteoclast progenitors from cats with and without tooth resorption respond differently to 1,25-dihydroxyvitamin D and interleukin-6. Research in Veterinary Science, 92(2), 311-316. https://doi.org/10.1016/j.rvsc.2011.03.014

2011

Scholarly publications

Piek, C. J., Brinkhof, B., Teske, E., Rothuizen, J., Dekker, A., & Penning, L. C. (2011). High intravascular tissue factor expression in dogs with idiopathic immune-mediated haemolytic anaemia. Veterinary Immunology and Immunopathology, 144(2011), 346-354. https://doi.org/10.1016/j.vetimm.2011.08.010
Piek, C. J., Brinkhof, B., Rothuizen, J., Dekker, A., & Penning, L. C. (2011). Leukocyte count affects expression of reference genes in canine whole blood samples. BMC Research Notes, 4, 1-8. [36]. https://doi.org/10.1186/1756-0500-4-36
Favier, R. P., Spee, B., Penning, L. C., & Rothuizen, J. (2011). Copper-induced hepatitis: the COMMD1 deficient dog as a translational animal model for human chronic hepatitis. Veterinary Quarterly, 31(1), 49-60. https://doi.org/10.1080/01652176.2011.563146
Kruitwagen, H. S., Arends, B., Spee, B., Brinkhof, B., van den Ingh, T. S. G. A. M., Rutten, V. P. M. G., Penning, L. C., Roskams, T., & Rothuizen, J. (2011). Recombinant hepatocyte growth factor treatment in a canine model of congenital liver hypoplasia. Liver International, 31(7), 940-949. https://doi.org/10.1111/j.1478-3231.2011.02513.x

Professional publications

Otte, C., Penning, L. C., Rothuizen, J., & Favier, R. P. (2011). [Cholangitis in cats: symptoms, cause, diagnosis, treatment, and prognosis.]. Tijdschrift voor Diergeneeskunde, 136(5), 332-338. http://www.ncbi.nlm.nih.gov/pubmed/21614849

2010

Scholarly publications

van Rijn, S. J., Grinwis, G. C. M., Penning, L. C., & Meij, B. P. (2010). Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas. Domestic Animal Endocrinology, 38(4), 244-252. https://doi.org/10.1016/j.domaniend.2009.11.003
Kuijk, E. W., van Mil, A., Brinkhof, B., Penning, L. C., Colenbrander, B., & Roelen, B. A. J. (2010). PTEN and TRP53 independently suppress Nanog expression in spermatogonial stem cells. Stem Cells and Development, 19, 979-988.
Booij-Vrieling, H. E., van der Reijden, W. A., Houwers, D. J., de Wit, W. E., Bosch-Tijhof, C. J., Penning, L. C., van Winkelhoff, A. J., & Hazewinkel, H. A. W. (2010). Comparison of periodontal pathogens between cats and their owners. Veterinary Microbiology, 144(1-2), 147-152. https://doi.org/10.1016/j.vetmic.2009.12.046
Vrieling, H. E., Ferbus, D., Tryfonidou, M. A., Riemers, F. M., Penning, L. C., Berdal, A., Everts, V., & Hazewinkel, H. A. W. (2010). Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats. European Journal of Oral Sciences, 118(1), 39-46. https://doi.org/10.1111/j.1600-0722.2009.00707.x
https://dspace.library.uu.nl/bitstream/handle/1874/204556/j.1600-0722.2009.00707.x.pdf?sequence=3
Bustin, S. A., Beaulieu, J. F., Huggett, J., Jaggi, R., Kibenge, F. S., Olsvik, P. A., Penning, L. C., & Toegel, S. (2010). MIQE précis: Practical implementation of minimum standard guidelines for fluorescence-based quantitative real-time PCR experiments. BMC Molecular Biology [E], 11, 1-5. [74]. https://doi.org/10.1186/1471-2199-11-74
https://dspace.library.uu.nl/bitstream/handle/1874/204686/MIQE%2520pr_233_cis%2520Practical%2520implementation.pdf?sequence=1
Tryfonidou, M. A., Hazewinkel, H. A. W., Riemers, F. M., Brinkhof, B., Penning, L. C., & Karperien, M. (2010). Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators. American Journal of Physiology-Endocrinology and Metabolism, 299(6), 1044-1052. https://doi.org/10.1152/ajpendo.00170.2010
IJzer, J., Schotanus, B. A., Vander Borght, S., Roskams, T. A., Kisjes, R., Penning, L. C., Rothuizen, J., & van den Ingh, T. S. G. A. M. (2010). Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: An immunohistochemical comparison between dog and man. Veterinary Journal, 184, 308-314. https://doi.org/10.1016/j.tvjl.2009.02.016
Sprundel, R. G., van den Ingh, T. S. G. A. M., Desmet, V. J., Katoonizadeh, A., Penning, L. C., Rothuizen, J., Roskams, T., & Spee, B. (2010). Keratin 19 marks poor differentiation and a more aggressive behaviour in canine and human hepatocellular tumours. Comparative Hepatology, 9. https://doi.org/10.1186/1476-5926-9-4

Other output

Rutges, J. P. H. J., Bergknut, N., van Tiel, J., Waarsing, H. J., Meij, B. P., Hazewinkel, H. A. W., Penning, L. C., Lagerstedt, A. S., Hagman, R. E., Dhert, W. J. A., & Creemers, L. B. (2010). Correlation of biochemical, histological and imaging parameters of intervertebral disc degeneration in a rabbit annular puncture model. 1406-1407. Abstract from 3rd International Congress Biotechnologies for Spinal Surgery, BIOSPINE 3, Amsterdam.
van Rijn, S. J., Gremeaux, L., Riemers, F. M., Penning, L. C., Meij, B. P., & Vankelecom, H. (Accepted/In press). Identification and characterization of side population cells in the canine pituitary gland. 270-270. Abstract from European Veterinary Conference Voorjaarsdagen, Amsterdam.
van Rijn, S. J., Meij, B. P., Gremeaux, L., Vankelecom, H., & Penning, L. C. (Accepted/In press). Identification and characterization of a side population of cells isolated after fluorescence activated cell sorting of the canine pituitary gland. 73-73. Abstract from European Neuroendocrine Association (ENEA), Liège, Belgium.
Smidt, H., Bergknut, N., Meij, B. P., Lagerstedt, A. S., & Penning, L. C. (Accepted/In press). A comparative study on MMP-2 activity and GAG concentration during subsequent stages of canine intervertebral disc degeneration. 266-267. Abstract from European Veterinary Conference Voorjaarsdagen, Amsterdam.

2009

Scholarly publications

Vrieling, H. E., Tryfonidou, M. A., Riemers, F. M., Penning, L. C., & Hazewinkel, H. A. W. (2009). Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats. Veterinary Immunology and Immunopathology, 132, 160-166.
Fieten, H., Spee, B., Ijzer, J., Kik, M. J., Penning, L. C., & Kirpensteijn, J. (2009). Expression of hepatocyte growth factor and the proto-oncogenic receptor c-Met in canine osteosarcoma. Veterinary Pathology, 46(5), 869-877. https://doi.org/10.1354/vp.08-VP-0155-F-FL
Hoffmann, G., IJzer, J., Brinkhof, B., Schotanus, B. A., van den Ingh, T. S. G. A. M., Penning, L. C., & Rothuizen, J. (2009). Comparison of different methods to obtain and store liver biopsies for molecular and histological research. Comparative Hepatology, 8, 3. https://doi.org/10.1186/1476-5926-8-3
Arends, B., Spee, B., Schotanus, B. A., Roskams, T., van den Ingh, T. S. G. A. M., Penning, L. C., & Rothuizen, J. (2009). In vitro differentiation of liver progenitor cells derived from healthy dog livers. Stem Cells and Development, 18(2), 351-358.
Schotanus, B. A., van den Ingh, T. S. G. A. M., Penning, L. C., Rothuizen, J., Roskams, T. A., & Spee, B. (2009). Cross-species immunohistochemical investigation of the activation of the liver progenitor cell niche in different types of liver disease. Liver International, 28(9), 1241-1252.
Arends, B., Vankelecom, H., van der Borght, S., Roskams, T., Penning, L. C., Rothuizen, J., & Spee, B. (2009). The dog liver contains a "side population" of cells with hepatic progenitor-like characteristics. Stem Cells and Development, 18(2), 343-350. https://doi.org/10.1089/scd.2008.0022
Schlotter, Y. M., Veenhof, E. Z., Brinkhof, B., Rutten, V. P. M. G., Spee, B., Willemse, A., & Penning, L. C. (2009). A GeNorm algorithm-based selection of reference genes for quantitative real-time PCR in skin biopsies of healthy dogs and dogs with atopic dermatitis. Veterinary Immunology and Immunopathology, 129(1-2), 115-118.
IJzer, J., Kisjes, R., Penning, L. C., Rothuizen, J., & van den Ingh, T. S. G. A. M. (2009). The progenitor cell compartment in the feline liver: an (immuno)histochemical investigation. Veterinary Pathology, 46(4), 614-621.
Poldervaart, J. H., Favier, R. P., Penning, L. C., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2009). Primary hepatitis in dogs: a retrospective review (2002-2006). Journal of Veterinary Internal Medicine, 23(1), 72-80.

2008

Scholarly publications

Arends, B., Spee, B., Hoffmann, G., Jansen, G. E. G., Slump, E., Auriemma, E., IJzer, J., Hemrika, W., Romijn, R. A. P., Van der Heijden-Liefkens, K. H. A., Sondermeijer, P. J. A., van den Ingh, T. S. G. A. M., Penning, L. C., & Rothuizen, J. (2008). In vitro and in vivo bioactivity of recombinant canine hepatocyte growth factor. Veterinary Journal, 178, 70-77.
https://dspace.library.uu.nl/bitstream/handle/1874/32230/2.pdf?sequence=1
Schotanus, B. A., de Gier, J., van der Lugt, J. J., Schaefers-Okkens, A. C., & Penning, L. C. (2008). Estriolum treatment in the bitch: a risk for uterine infection? Reproduction in Domestic Animals, 43(2), 176-180.
https://dspace.library.uu.nl/bitstream/handle/1874/31972/schotanus%2520et%2520al%25202008.pdf?sequence=2
Arends, B., Slump, E., Spee, B., Rothuizen, J., & Penning, L. C. (2008). Hepatocyte growth factor improves viability after H2O2-induced toxicity in bile duct epithelial cells. Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology, 147(3), 324-330.

2007

Scholarly publications

Spee, B., Arends, B., Vankelecom, H., Rothuizen, J., Penning, L. C., & Roslams, T. A. (2007). Side-population analysis in healthy canine livers, a new source of liver specific progenitor cells? In Molecular Mechanisms of Regeneration / From Stem Cells to Organ Development, Function and Regeneration"
Spee, B., Arends, B., van den Ingh, T. S. G. A. M., Roskams, T., Rothuizen, J., & Penning, L. C. (2007). Major HGF-mediated regenerative pathways are similarly affected in human and canine cirrhosis. Comparative Hepatology, 6, 8. https://doi.org/10.1186/1476-5926-6-8
Penning, L. C., Vrieling, H. E., Brinkhof, B., Rothuizen, J., Rutteman, G. R., & Hazewinkel, H. A. W. (2007). A validation of 10 feline reference genes for gene expression measurements in snap-frozen tissues. Veterinary Immunology and Immunopathology, 120(15-12-2007), 212-222.
Spee, B., Arends, B., Wees, A. M., Bode, P., Penning, L. C., & Rothuizen, J. (2007). Functional consequences of RNA interference targeting COMMD1 in a canine hepatic cell line in relation to copper toxicosis. Animal Genetics, 38, 168-170.
https://dspace.library.uu.nl/bitstream/handle/1874/26165/Spee%2C%2520Arends%2C%2520Wees%2520van%2C%2520Bode%2C%2520Penning%2C%2520Rothuizen-Functional%2520consequences%2520of%2520RNA%2520interference%2520targeting%2520COMMD1%2520in%2520a%2520canine%2520hepatic%2520cell%2520line%2520in%2520relation%2520to%2520copper%2520toxicosis.pdf?sequence=1
Favier, R. P., Poldervaart, J. H., van den Ingh, T. S. G. A. M., Penning, L. C., & Rothuizen, J. (2007). Hepatitis in dogs: different forms and the role of prednisone treatment. In Hepatitis in dogs: different forms and the role of prednisone treatment (pp. 120-122)
Poldervaart, J. H., Favier, R. P., van den Ingh, T. S. G. A. M., Penning, L. C., & Rothuizen, J. (2007). Evaluation of prednisone treatment in canine idiopathic chronic hepatitis by using quantitative RT-PCR and immunochemistry. In Evaluation of prednisone treatment in canine idiopathic chronic hepatitis by using quantitative RT-PCR and immunochemistry (pp. 221-222)

2006

Scholarly publications

Spee, B., Arends, B., van den Ingh, T. S. G. A. M., Penning, L. C., & Rothuizen, J. (2006). Copper metabolism and oxidative stress in chronic inflammatory and cholestatic liver diseases in dogs. Journal of Veterinary Internal Medicine, 20, 1085-1092.
IJzer, J., Roskams, T., Molenbeek, R. F., Ultee, A., Penning, L. C., Rothuizen, J., & van den Ingh, T. S. G. A. M. (2006). Morphological characterisation of portal myofibroblasts and hepatic stellate cells in the normal dog liver. Comparative Hepatology, 5, 7.
https://dspace.library.uu.nl/bitstream/handle/1874/20226/1476-5926-5-7.pdf?sequence=3
Penning, L. C., Piek, C. J., Eib, D. W., Schipper, R. G., Holling, T. M., & Martens, G. J. (2006). Induction of apoptosis in hematopoietic cells with an antibody against tomoregulin-1. Anticancer Research, 26, 339-346.
https://dspace.library.uu.nl/bitstream/handle/1874/20225/Penning%2C%2520Piek%2C%2520ea%2C%2520Apoptosis%2520haematopoietic%2520cells%2Ccan%2520be%2Cinduced%2520with%2520an%2520antibody%2520against%2520tomeregulin%25201.pdf?sequence=1
Spee, B., Jonkers, M. D., Arends, B., Rutteman, G. R., Rothuizen, J., & Penning, L. C. (2006). Specific down-regulation of XIAP with RNA interference enhances the sensitivity of canine tumor cell-lines to TRAIL and doxorubicin. Molecular Cancer, 5(34).
https://dspace.library.uu.nl/bitstream/handle/1874/20238/Spee%2C%2520Jonkers%2C%2520Arends%2C%2520Rutteman%2C%2520Rothuizen%2C%2520Penning%2520-%2520Specific%2520down-regulation%2520of%2520XIAP%2520with%2520RNA%2520interference%2520enhances%2520the%2520sensitivity%2520of%2520canine%2520tumor%2520cell-lines%2520to%2520TRAIL%2520and%2520doxorubicin.pdf?sequence=1
Brinkhof, B., Spee, B., Rothuizen, J., & Penning, L. C. (2006). Development and evaluation of canine reference genes for accurate quantification of gene expression. Analytical Biochemistry, 356, 36-43.
https://dspace.library.uu.nl/bitstream/handle/1874/20199/Brinkhof%2C%2520Spee%2C%2520Rothuizen%2C%2520Penning-Development%2520and%2520evaluation%2520of%2520canine%2520reference%2520genes%2520for%2520accurate%2520quantification%2520of%2520gene%2520expression.pdf?sequence=1
Spee, B., Arends, B., van den Ingh, T. S. G. A. M., Brinkhof, B., IJzer, J., Nederbragt, H., Penning, L. C., & Rothuizen, J. (2006). TGFB-1 signalling in canine hepatic diseases, new models for human fibrotic liver pathologies. Liver International, 26(6), 716-725.

2005

Scholarly publications

Boomkens, S. Y., de Rave, S., Pot, R. G., Egberink, H. F., Penning, L. C., Rothuizen, J., Zondervan, P. E., & Kusters, J. G. (2005). The role of helicobacter species in the pathogenesis of primary biliary cirrhosis and primary sclerosing cholangitis. FEMS Immunology and Medical Microbiology, 44(2), 221-225.
Spee, B., Penning, L. C., van den Ingh, T. S. G. A. M., Arends, B., IJzer, J., van Sluijs, F. J., & Rothuizen, J. (2005). Regenerative and fibrotic pathways in canine hepatic portosystemic shunt and portal vein hypoplasia, new models for clinical hepatocyte growth factor treatment. Comparative Hepatology, 4(7), 1-11.
Boomkens, S. Y., Slump, E., Egberink, H. F., Rothuizen, J., & Penning, L. C. (2005). PCR screening for candidate etiological agents of canine hepatitis. Veterinary Microbiology, 108((1-2)), 49-55.
Spee, B., Arends, B., van den Ingh, T. S. G. A. M., Brinkhof, B., Nederbragt, H., IJzer, J., Penning, L. C., & Rothuizen, J. (2005). Pathways of liver fibrosis and regeneration in the dog as a basis for new therapies. In ECVIM-CA Congress Proceedings (pp. 179-181)
Favier, R. P., Spee, B., Penning, L. C., Brinkhof, B., & Rothuizen, J. (2005). Quantitative PCR method to detect a 13-kb deletion in the MURR1 gene associated with copper toxicosis and HIV-1 replication. Mammalian Genome, 16, 460-463.
Penning, L. C., Spee, B., Rothuizen, J., & Rutteman, G. R. (2005). Use of regenerative pathways by tumors ? Expression of oncogenes, tumor suppressor genes and gene products involved in cell- cell interactions in canine liver diseases. In G. R. Rutteman, & L. C. Penning (Eds.), Tumor Cell Stromal Cell Interactions (pp. 5-6).
Kummeling, A., Rothuizen, J., Penning, L. C., Brinkhof, B., & van Sluijs, F. J. (2005). Prognostic factors for congenital portosystemic shunts based on gene expression profiles. In ECVIM-CA Congress Proceedings (pp. 185-187)
Spee, B., Mandigers, P. J. J., Arends, B., Bode, P., van den Ingh, T. S. G. A. M., Hoffmann, G., Rothuizen, J., & Penning, L. C. (2005). Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinschers. Comparative Hepatology, 4(3), 1-13.

2004

Scholarly publications

Boomkens, S. Y., Spee, B., IJzer, J., Kisjes, R., Egberink, H. F., van den Ingh, T. S. G. A. M., Rothuizen, J., & Penning, L. C. (2004). The establishment and characterization of the first canine hepatocellular carcinoma cell line, which resembles human oncogenic expression patterns. Comparative Hepatology, 3, 9.
Mandigers, P. J. J., van den Ingh, T. S. G. A. M., Spee, B., Penning, L. C., Bode, P., & Rothuizen, J. (2004). Chronic hepatitis in Doberman pinschers. A review. Veterinary Quarterly, 26(3), 99-106.
Penning, L. C. (2004). Regulation of genes involved in liver regeneration and fibrosis in dogs with acute and chronic hepatitis. In Congress Proceedings, 14th ECVIM-CA Congress, 9th-11th september 2004,Barcelona, Spain (pp. 124-126).
Boomkens, S. Y., Penning, L. C., Egberink, H. F., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2004). Hepatitis with special reference to dogs. A review on the pathogenesis and infectious etiologies, including unpublished results of recent own studies. Veterinary Quarterly, 26(3), 107-114. https://doi.org/10.1080/01652176.2004.9695174
Mandigers, P. J. J., van den Ingh, T. S. G. A. M., Spee, B., Penning, L. C., & Rothuizen, J. (2004). The pathogenesis of Doberman hepatitis. In 14th Symposium ECVIM-CA (pp. 120-123)
Boomkens, S. Y., Kusters, J. G., Hoffmann, G., Pot, R. G., Spee, B., Penning, L. C., Egberink, H. F., van den Ingh, T. S. G. A. M., & Rothuizen, J. (2004). Detection of Helicobacter pylori in bile of cats. FEMS Immunology and Medical Microbiology, 42, 307-311. https://doi.org/10.1016/j.femsim.2004.06.002

2002

Scholarly publications

Michon, I. N., Penning, L. C., Molenaar, T. J. M., Biessen, E. A. L., van Berkel, T. J., & Kuiper, J. D. (2002). TGF-beta-like peptides and their effect on vascular smooth muscle cells in vitro. Biochemical and Biophysical Research Communications, 293, 1279-1286.

2000

Scholarly publications

Schipper, R. G., Penning, L. C., & Verhofstad, A. A. (2000). Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors? Seminars in Cancer Biology, 10(1), 55-68. https://doi.org/10.1006/scbi.2000.0308
Penning, L. C., Denecker, G., Vercammen, D., Declercq, W., Schipper, R. G., & Vandenabeele, P. (2000). A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines. Cytokine, 12(6), 747-50. https://doi.org/10.1006/cyto.1999.0626

1998

Scholarly publications

Penning, L. C., Schipper, R. G., Vercammen, D., Verhofstad, A. A., Denecker, T., Beyaert, R., & Vandenabeele, P. (1998). Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines. Cytokine, 10(6), 423-31. https://doi.org/10.1006/cyto.1997.0310

1997

Scholarly publications

Denecker, G., Vandenabeele, P., Grooten, J., Penning, L. C., Declercq, W., Beyaert, R., Buurman, W. A., & Fiers, W. (1997). Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma. Cytokine, 9(9), 631-8. https://doi.org/10.1006/cyto.1997.0218

1995

Scholarly publications

Fiers, W., Beyaert, R., Boone, E., Cornelis, S., Declercq, W., Decoster, E., Denecker, G., Depuydt, B., De Valck, D., De Wilde, G., Goossens, V., Grooten, J., Haegeman, G., Heyninck, K., Plaisance, S., Vancompernolle, K., Van Criekinge, W., Vandenabeele, P., Vanden Berghe, W., ... Penning, L. (1995). TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis. Journal of Inflammation (Wiley-Liss), 47(1-2), 67-75.
Los, M., Van de Craen, M., Penning, L. C., Schenk, H., Westendorp, M., Baeuerle, P. A., Dröge, W., Krammer, P. H., Fiers, W., & Schulze-Osthoff, K. (1995). Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature, 375(6526), 81-3. https://doi.org/10.1038/375081a0

1994

Scholarly publications

Penning, L. C., Tijssen, K., Boegheim, J. P., van Steveninck, J., & Dubbelman, T. M. (1994). Relationship between photodynamically induced damage to various cellular parameters and loss of clonogenicity in different cell types with hematoporphyrin derivative as sensitizer. Biochimica et Biophysica Acta, 1221(3), 250-8.
Penning, L. C., & Dubbelman, T. M. (1994). Fundamentals of photodynamic therapy: cellular and biochemical aspects. Anti-Cancer Drugs, 5(2), 139-46.
Penning, L. C., Tijssen, K., VanSteveninck, J., & Dubbelman, T. M. (1994). Hematoporphyrin derivative-induced photodynamic inhibition of Na+/K(+)-ATPase in L929 fibroblasts, Chinese hamster ovary cells and T24 human bladder transitional carcinoma cells. Photochemistry and Photobiology, 59(3), 336-341. https://doi.org/10.1111/j.1751-1097.1994.tb05043.x
Penning, L. C., Lagerberg, J. W., VanDierendonck, J. H., Cornelisse, C. J., Dubbelman, T. M., & VanSteveninck, J. (1994). The role of DNA damage and inhibition of poly(ADP-ribosyl)ation in loss of clonogenicity of murine L929 fibroblasts, caused by photodynamically induced oxidative stress. Cancer Research, 54(21), 5561-5567.

1993

Scholarly publications

Penning, L. C., VanSteveninck, J., & Dubbelman, T. M. (1993). HPD-induced photodynamic changes in intracellular cyclic AMP levels in human bladder transitional carcinoma cells, clone T24. Biochemical and Biophysical Research Communications, 194(3), 1084-9. https://doi.org/10.1006/bbrc.1993.1932
Penning, L. C., Keirse, M. J., VanSteveninck, J., & Dubbelman, T. M. (1993). Ca(2+)-mediated prostaglandin E2 induction reduces haematoporphyrin-derivative-induced cytotoxicity of T24 human bladder transitional carcinoma cells in vitro. Biochemical Journal, 292 ( Pt 1), 237-40.

1992

Scholarly publications

Penning, L. C., Rasch, M. H., Ben-Hur, E., Dubbelman, T. M., Havelaar, A. C., Van der Zee, J., & Van Steveninck, J. (1992). A role for the transient increase of cytoplasmic free calcium in cell rescue after photodynamic treatment. Biochimica et Biophysica Acta, 1107(2), 255-60.
Prinsze, C., Penning, L. C., Dubbelman, T. M., & VanSteveninck, J. (1992). Interaction of photodynamic treatment and either hyperthermia or ionizing radiation and of ionizing radiation and hyperthermia with respect to cell killing of L929 fibroblasts, Chinese hamster ovary cells, and T24 human bladder carcinoma cells. Cancer Research, 52(1), 117-20.

1989

Scholarly publications

Van Haastert, P. J., De Vries, M. J., Penning, L. C., Roovers, E., Van der Kaay, J., Erneux, C., & Van Lookeren Campagne, M. M. (1989). Chemoattractant and guanosine 5'-[gamma-thio]triphosphate induce the accumulation of inositol 1,4,5-trisphosphate in Dictyostelium cells that are labelled with [3H]inositol by electroporation. Biochemical Journal, 258(2), 577-86.

1988

Scholarly publications

De Wit, R. J., van Bemmelen, M. X., Penning, L. C., Pinas, J. E., Calandra, T. D., & Bonner, J. T. (1988). Studies of cell-surface glorin receptors, glorin degradation, and glorin-induced cellular responses during development of Polysphondylium violaceum. Experimental Cell Research, 179(2), 332-43.

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