dr. ir. L.A. (Lidwien) Smit
L.A.Smit@uu.nl
Gegenereerd op 2017-11-18 01:50:50


Profile

Lidwien Smit is an epidemiologist with expertise in environmental and genetic risk factors for allergic, respiratory and infectious diseases. Her current research and teaching focuses on environmental epidemiology at the animal-human interface, with a strong interest in molecular epidemiology and multidisciplinary research.

She obtained a Master of Science degree (cum laude) in Environmental Sciences from Wageningen University, and a PhD degree from Utrecht University in 2008 ("Respiratory effects of endotoxin exposure: individual susceptibility and gene-environment interactions"). During her post-doctoral fellowship at INSERM in Paris, she analyzed genome-wide data to investigate gene-environment interactions in European asthma cohorts.

Currently, she is a project leader in a large-scale study on respiratory health, zoonotic infections, and antimicrobial resistance among neighboring residents of livestock farms. She is leading the respiratory health part, for which she obtained a research grant from the Netherlands Lung Foundation. In addition, she is involved in several other national and international studies (e.g. EU FP7: HERA, EFFORT). 

Gegenereerd op 2017-11-18 01:50:50
Curriculum vitae

Education

2008, PhD, Utrecht University, The Netherlands.

2001, MSc (cum laude), Environmental Sciences, Wageningen University, The Netherlands.

Positions

2013 - present, Assistant Professor, Institute for Risk Assessment Sciences, Utrecht University, The Netherlands.

2009 – 2013, Researcher, Institute for Risk Assessment Sciences, Utrecht University, The Netherlands.

2008 – 2009, Postdoctoral fellow, INSERM, Epidemiology and Biostatistics U780, Paris, France.

2007, Visiting researcher, INSERM, U780, Paris, France.

2003 – 2008, PhD student, Institute for Risk Assessment Sciences, Utrecht University, The Netherlands.

2001 – 2002, Consultant, International Water Management Institute, Colombo, Sri Lanka.

Awards

  • ERS/ELF Best Abstract Grant for Healthy Lungs for Life (2016). 
  • Aart van Keulen prize (2010). Best article in Tijdschrift voor Diergeneeskunde (2007-2009) on veterinary public health.
  • European Respiratory Society, young scientist sponsorship to attend ERS conferences (2009 and 2010).
  • NWO/French Dutch Academy, Van Gogh travel grant for French-Dutch cooperation (2009).
  • EAACI-GA2LEN exchange fellowship award (2008), used for postdoctoral fellowship in Paris.

Key publications

Borlée F, Yzermans CJ, Aalders B, Rooijackers J, Krop E, Maassen CBM, Schellevis F, Brunekreef B, Heederik D, Smit LAM. Air pollution from livestock farms is associated with airway obstruction in neighboring residents. Am J Respir Crit Care Med 2017; in press.

Borlée F, Yzermans CJ, Van Dijk CE, Heederik D, Smit LAM. Increased respiratory symptoms in COPD patients living in the vicinity of livestock farms. Eur Respir J 2015; 46:1605-14.

Smit LAM, Lenters V, Høyer BB, Lindh CH, Pedersen HS, Liermontova I, Jönsson BAG, Piersma AH, Bonde JP, Toft G, Vermeulen R, Heederik D. Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children. Allergy 2015; 70:653-60.

Smit LAM, Strachan DP, Vermeulen R, De Bakker PIW, Demenais F, Dumas O, Carsin AE, Cullinan P, Curjuric I, Ghosh RE, Heederik D, Imboden M, Jarvis D, Lathrop M, Le Moual N, Mehta A, Miedinger D, Sigsgaard T, Siroux V, Vernez D, Zock JP, Kauffmann F, Probst-Hensch N, Kogevinas M, Bouzigon E. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role? Eur Respir J 2014;44:1234-42.

Smit LAM, Hooiveld M, Van der Sman-de Beer F, Opstal-van Winden AWJ, Beekhuizen J, Wouters IM, Yzermans CJ, Heederik D. Air pollution from livestock farms and asthma, allergic rhinitis, and COPD among neighbouring residents. Occup Environ Med 2014;71:134-40.

Smit LAM, Siroux V, Bouzigon E, Oryszczyn MP, Lathrop M, Demenais F, Kauffmann F. CD14 and Toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 2009; 179:363-8.

Eddleston M, Karalliedde L, Buckley N, Fernando R, Hutchinson G, Isbister G, Konradsen F, Murray D, Piola JC, Senanayake N, Sheriff R, Singh S, Siwach SB, Smit L. Pesticide poisoning in the developing world - a minimum pesticides list. Lancet 2002; 360: 1163-7.

Gegenereerd op 2017-11-18 01:50:50
All publications
  Articles - 2017
Borlée, Floor, Yzermans, C Joris, Aalders, Bernadette, Rooijackers, Jos, Krop, Esmeralda, Maassen, Catharina B M, Schellevis, François, Brunekreef, Bert, Heederik, Dick & Smit, Lidwien A M (2017). Air Pollution from Livestock Farms is Associated with Airway Obstruction in Neighboring Residents. American Journal of Respiratory and Critical Care Medicine
Baliatsas, Christos, Borlée, Floor, van Dijk, Christel E, van der Star, Baukje, Zock, Jan-Paul, Smit, Lidwien A M, Spreeuwenberg, Peter, Heederik, Dick & Yzermans, C Joris (2017). Comorbidity and coexisting symptoms and infections presented in general practice by COPD patients - Does livestock density in the residential environment play a role?. International Journal of Hygiene and Environmental Health Copyright © 2017 Elsevier GmbH. All rights reserved..
Timmerman, Johan G, Heederik, Dick, Spee, Ton, van Rooy, Frits G, Krop, Esmeralda J M, Rustemeyer, Thomas & Smit, Lidwien A M (18.08.2017). Contact dermatitis is an unrecognized problem in the construction industry - Comparison of four different assessment methods. American Journal of Industrial Medicine © 2017 Wiley Periodicals, Inc..
Wielders, C C H, van Hoek, A H A M, Hengeveld, P D, Veenman, C, Dierikx, C M, Zomer, T P, Smit, L A M, van der Hoek, W, Heederik, D J, de Greeff, S C, Maassen, C B M & van Duijkeren, E (2017). Extended-spectrum β-lactamase- and pAmpC-producing Enterobacteriaceae among the general population in a livestock-dense area. Clinical Microbiology and Infection, 23 (2), (pp. 120.e1–120.e8). Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved..
Kramer, Tineke, Jansen, Leonie E., Lipman, Len J.A., Smit, Lidwien A.M., Heederik, Dick J.J. & Dorado-García, Alejandro (01.11.2017). Farmers’ knowledge and expectations of antimicrobial use and resistance are strongly related to usage in Dutch livestock sectors. Preventive Veterinary Medicine, 147, (pp. 142-148) (7 p.).
van Dijk, Christel E, Zock, Jan-Paul, Baliatsas, Christos, Smit, Lidwien A M, Borlée, Floor, Spreeuwenberg, Peter, Heederik, Dick & Yzermans, C Joris (2017). Health conditions in rural areas with high livestock density - Analysis of seven consecutive years. Environmental Pollution, 222, (pp. 374-382). Copyright © 2016 Elsevier Ltd. All rights reserved..
van Gageldonk-Lafeber, Arianne B, van der Hoek, Wim, Borlée, Floor, Heederik, Dick J J, Mooi, Sofie H, Maassen, Catharina B M, Yzermans, C Joris, Rockx, Barry, Smit, Lidwien A M & Reimerink, Johan H J (05.01.2017). Hepatitis E virus seroprevalence among the general population in a livestock-dense area in the Netherlands - a cross-sectional population-based serological survey. BMC Infectious Diseases, 17 (1), (pp. 21).
Smit, L.A. & Heederik, D.J.J. (13.09.2017). Impacts of intensive livestock production on human health in densely populated regions. GeoHealth (6 p.).
Smit, L.A., Boender, G.J., de Steenhuijsen Piters, W.A.A., Hagenaars, T.J., Huijskens, E G W, Rossen, John W A, Koopmans, M., Nodelijk, G., Sanders, Elisabeth A M, Yzermans, J., Bogaert, D. & Heederik, D. (25.02.2017). Increased risk of pneumonia in residents living near poultry farms: does the upper respiratory tract microbiota play a role?. Pneumonia, 9.
Freidl, Gudrun S, Spruijt, Ineke T, Borlée, Floor, Smit, Lidwien A M, van Gageldonk-Lafeber, Arianne B, Heederik, Dick J J, Yzermans, Joris, van Dijk, Christel E, Maassen, Catharina B M & van der Hoek, Wim (31.03.2017). Livestock-associated risk factors for pneumonia in an area of intensive animal farming in the Netherlands. PLoS One, 12 (3), (pp. e0174796).
Klous, Gijs, Smit, Lidwien A M, Borlée, Floor, Coutinho, Roel A, Kretzschmar, Mirjam E. E., Heederik, Dick J J & Huss, Anke (09.08.2017). Mobility assessment of a rural population in the Netherlands using GPS measurements. International Journal of Health Geographics, 16 (1), (pp. 30).
Zomer, Tizza P, Wielders, Cornelia C H, Veenman, Christiaan, Hengeveld, Paul, van der Hoek, Wim, de Greeff, Sabine C, Smit, Lidwien A M, Heederik, Dick J, Yzermans, C Joris, Bosch, Thijs, Maassen, Catharina B M & van Duijkeren, Engeline (01.03.2017). MRSA in persons not living or working on a farm in a livestock-dense area - prevalence and risk factors. Journal of Antimicrobial Chemotherapy, 72 (3), (pp. 893-899) (7 p.). © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please email: journals.permissions@oup.com..
Downward, George S, van der Zwaag, Hugo P, Simons, Leon, Meliefste, Kees, Tefera, Yifokire, Carreon, J Rosales, Vermeulen, Roel & Smit, Lidwien A M (06.11.2017). Occupational exposure to indoor air pollution among bakery workers in Ethiopia; A comparison of electric and biomass cookstoves. Environmental Pollution, 233, (pp. 690-697) (8 p.). Copyright © 2017 Elsevier Ltd. All rights reserved..
Zomer, Tizza P, VAN Duijkeren, E, Wielders, C C H, Veenman, C., Hengeveld, P., {van der Hoek}, W., de Greeff, S C, Smit, L A M, Heederik, D J, Yzermans, C Joris, Kuijper, E J & Maassen, Catharina B M (14.08.2017). Prevalence and risk factors for colonization of Clostridium difficile among adults living near livestock farms in the Netherlands. Epidemiology and Infection, (pp. 1-5) (5 p.).
Borlée, Floor, Yzermans, C Joris, Krop, Esmeralda, Aalders, Bernadette, Rooijackers, Jos, Zock, Jan-Paul, van Dijk, Christel E, Maassen, Catharina B M, Schellevis, François, Heederik, Dick & Smit, Lidwien A M (2017). Spirometry, questionnaire and electronic medical record based COPD in a population survey - Comparing prevalence, level of agreement and associations with potential risk factors. PLoS One, 12 (3), (pp. e0171494).
  Articles - 2016
van Dijk, Christel E, Smit, Lidwien A M, Hooiveld, Mariette, Zock, Jan-Paul, Wouters, Inge M, Heederik, Dick J J & Yzermans, C Joris (21.02.2016). Associations between proximity to livestock farms, primary health care visits and self-reported symptoms. BMC Family Practice, 17 (1), (pp. 22).
Timmerman, J G, Heederik, D, Spee, T, van Rooy, F G, Krop, E J M, Koppelman, G H, Rustemeyer, T & Smit, L A M (2016). Contact dermatitis in the construction industry - the role of filaggrin loss-of-function mutations. British Journal of Dermatology, 174 (2), (pp. 348-355) (8 p.). This article is protected by copyright. All rights reserved..
de Rooij, Myrna M T, Borlée, Floor, Smit, Lidwien A M, de Bruin, Arnout, Janse, Ingmar, Heederik, Dick J J & Wouters, Inge M (2016). Detection of Coxiella burnetii in Ambient Air after a Large Q Fever Outbreak. PLoS One, 11 (3).
Spee, Ton, Timmerman, Johan G, Rühl, Reinhold, Kersting, Klaus, Heederik, Dick J J & Smit, Lidwien A M (29.01.2016). Determinants of epoxy allergy in the construction industry - a case-control study. Contact Dermatitis, 74 (5), (pp. 259-266) (8 p.). © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd..
Hooiveld, Mariëtte, Smit, Lidwien A M, van der Sman-de Beer, Femke, Wouters, Inge M, van Dijk, Christel E, Spreeuwenberg, Peter, Heederik, Dick J J & Yzermans, C Joris (2016). Doctor-diagnosed health problems in a region with a high density of concentrated animal feeding operations - a cross-sectional study. Environmental Health: A Global Access Science Source, 15 (1), (pp. 1-9).
Huijskens, E G W, Smit, L A M, Rossen, J W A, Heederik, D & Koopmans, M (2016). Evaluation of Patients with Community-Acquired Pneumonia Caused by Zoonotic Pathogens in an Area with a High Density of Animal Farms. Zoonoses and Public Health, 63 (2), (pp. 160-166) (7 p.). © 2015 Blackwell Verlag GmbH..
Bloemsma, Lizan D, Hoek, Gerard & Smit, Lidwien A M (23.08.2016). Panel studies of air pollution in patients with COPD - Systematic review and meta-analysis. Environmental Research, 151, (pp. 458-468) (11 p.). Copyright © 2016 Elsevier Inc. All rights reserved..
van Dijk, Christel E, Garcia-Aymerich, Judith, Carsin, Anne-Elie, Smit, Lidwien A M, Borlée, Floor, Heederik, Dick J, Donker, Gé A, Yzermans, C Joris & Zock, Jan-Paul (2016). Risk of exacerbations in COPD and asthma patients living in the neighbourhood of livestock farms - Observational study using longitudinal data. International Journal of Hygiene and Environmental Health, 219 (3), (pp. 278–287) (10 p.). Copyright © 2016. Published by Elsevier GmbH..
Boers, D, Geelen, L, Erbrink, H, Smit, L A M, Heederik, D, Hooiveld, M, Yzermans, C J, Huijbregts, M & Wouters, I M (2016). The relation between modeled odor exposure from livestock farming and odor annoyance among neighboring residents. International Archives of Occupational and Environmental Health, 89 (3), (pp. 521-530) (10 p.).
  Articles - 2015
Bouzigon, E, Nadif, R, Le Moual, N, Dizier, M-H, Aschard, H, Boudier, A, Bousquet, J, Chanoine, S, Donnay, C, Dumas, O, Gormand, F, Jacquemin, B, Just, J, Margaritte-Jeannin, P, Matran, R, Pison, C, Rage, E, Rava, M, Sarnowski, C, Smit, Lidwien, Temam, S, Varraso, R, Vignoud, L, Lathrop, M, Pin, I, Demenais, F, Kauffmann, F & Siroux, V (2015). Facteurs génétiques et environnementaux de l'asthme et de l'allergie: synthèse des résultats de l'étude EGEA. Revue des Maladies Respiratoires, 32 (8), (pp. 822-840) (18 p.). Copyright © 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved..
Heederik, Dick & Smit, Lidwien A M (28.04.2015). Gender differences in lung function recovery after cessation of occupational endotoxin exposure: a complex story. Occupational and Environmental Medicine, 72 (8), (pp. 543-4) (2 p.).
Rava, Marta, Smit, Lidwien A M & Nadif, Rachel (2015). Gene-environment interactions in the study of asthma in the postgenomewide association studies era. Current Opinion in Allergy and Clinical Immunology, 15 (1), (pp. 70-78) (9 p.).
Spierenburg, E A J, Smit, L A M, Heederik, D, Robbe, P, Hylkema, M N & Wouters, I M (01.11.2015). Healthy worker survivor analysis in an occupational cohort study of Dutch agricultural workers. International Archives of Occupational and Environmental Health, 88 (8), (pp. 1165-1173) (9 p.).
Borlée, Floor, Yzermans, C Joris, van Dijk, Christel E, Heederik, Dick & Smit, Lidwien A M (2015). Increased respiratory symptoms in COPD patients living in the vicinity of livestock farms. European Respiratory Journal, 46 (6), (pp. 1605-1614) (10 p.). Copyright ©ERS 2015..
Hooiveld, Mariette, van Dijk, Christel, van der Sman-de Beer, Femke, Smit, Lidwien A M, Vogelaar, Maartje, Wouters, Inge M, Heederik, Dick J & Yzermans, C Joris (24.02.2015). Odour annoyance in the neighbourhood of livestock farming - perceived health and health care seeking behaviour. Annals of Agricultural and Environmental Medicine, 22 (1), (pp. 55-61) (7 p.).
Lenters, Virissa, Portengen, Lützen, Smit, Lidwien A M, Jönsson, Bo A G, Giwercman, Aleksander, Rylander, Lars, Lindh, Christian H, Spanò, Marcello, Pedersen, Henning S, Ludwicki, Jan K, Chumak, Lyubov, Piersma, Aldert H, Toft, Gunnar, Bonde, Jens Peter, Heederik, Dick & Vermeulen, Roel (01.06.2015). Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men. Occupational and Environmental Medicine, 72 (6), (pp. 385-393) (9 p.).
Smit, Lidwien A M, Lenters, Virissa, Høyer, Birgit Bjerre, Lindh, Christian H, Pedersen, Henning S, Liermontova, Iuliia, Jönsson, Bo A G, Piersma, Aldert H, Bonde, Jens Peter, Toft, Gunnar, Vermeulen, Roel & Heederik, Dick (2015). Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children. Allergy: European Journal of Allergy and Clinical Immunology, 70 (6), (pp. 653-660) (8 p.). This article is protected by copyright. All rights reserved..
  Articles - 2014
Smit, Lidwien A M, Hooiveld, Mariëtte, van der Sman-de Beer, Femke, Opstal-van Winden, Annemieke W J, Beekhuizen, Johan, Wouters, Inge M, Yzermans, C Joris & Heederik, Dick (2014). Air pollution from livestock farms, and asthma, allergic rhinitis and COPD among neighbouring residents. Occupational and Environmental Medicine, 71 (2), (pp. 134-40) (7 p.).
Smit, Lidwien A. M. & Heederik, Dick (01.10.2014). Are neighboring residents at risk of health effects from animal farm emissions?. Tijdschrift voor Diergeneeskunde, 138 (10), (pp. 22-26) (5 p.).
Smit, Lidwien A M, Strachan, David P, Vermeulen, Roel, de Bakker, Paul I W, Demenais, Florence, Dumas, Orianne, Carsin, Anne-Elie, Cullinan, Paul, Curjuric, Ivan, Ghosh, Rebecca E, Heederik, Dick, Imboden, Medea, Jarvis, Deborah, Lathrop, Mark, Le Moual, Nicole, Mehta, Amar, Miedinger, David, Sigsgaard, Torben, Siroux, Valérie, Vernez, David, Zock, Jan Paul, Kauffmann, Francine, Probst-Hensch, Nicole, Kogevinas, Manolis & Bouzigon, Emmanuelle (2014). Human leukocyte antigen class II variants and adult-onset asthma - does occupational allergen exposure play a role?. European Respiratory Journal, 44 (5), (pp. 1234-42) (9 p.). ©ERS 2014..
Timmerman, Johan G, Heederik, Dick, Spee, Ton & Smit, Lidwien A M (2014). Skin symptoms in the construction industry - occurrence and determinants. American Journal of Industrial Medicine, 57 (6), (pp. 660-8) (9 p.). © 2014 Wiley Periodicals, Inc..
Timmerman, Johan G, Zilaout, Hicham, Heederik, Dick, Spee, Ton & Smit, Lidwien A M (2014). Validation of a questionnaire on hand hygiene in the construction industry. Annals of Occupational Hygiene, 58 (8), (pp. 1046-56) (11 p.). © The Author 2014. Published by Oxford University Press on behalf of the British Occupational Hygiene Society..
  Articles - 2013
Lenters, V.C., Thomsen, C., Smit, L.A., Jönsson, B.A.G., Pedersen, H.S., Ludwicki, J.K., Zviezdai, V., Piersma, A.H., Toft, G., Bonde, J.P., Becher, G., Vermeulen, R. & Heederik, D. (2013). Serum concentrations of polybrominated diphenyl ethers (PBDEs) and a polybrominated biphenyl (PBB) in men from Greenland, Poland and Ukraine. Environmental International, 61, (pp. 8-16) (9 p.).
  Articles - 2012
Noss, I., Wouters, I.M., Smit, L.A., Meijer, E., Pronk, A., Heederik, D.J.J. & Doekes, G. (2012). IgG to Various Beta-Glucans in a Human Adult Population. International Archives of Allergy and Immunology, 157 (1), (pp. 98-108) (11 p.).
Smit, L.A., van der Sman-de Beer, F., Opstal-van Winden, A.W.J., Hooiveld, M., Beekhuizen, J., Wouters, I.M., Yzermans, J. & Heederik, D.J.J. (2012). Q Fever and pneumonia in an area with a high livestock density: a large population-based study. PLoS One, 7 (6), (pp. e38843) (1 p.).
Smit, L.A. (2012). Respiratory health effects in agricultural workers: are some more susceptible than others?. Expert Review of Respiratory Medicine, 6 (1), (pp. 7-10) (4 p.).
Basinas, I., Schlünssen, V., Heederik, D., Sigsgaard, T., Smit, L.A., Samadi, S., Omland, O., Hjort, C., Madsen, A.M., Skov, S. & Wouters, I.M. (2012). Sensitisation to common allergens and respiratory symptoms in endotoxin exposed workers: a pooled analysis. Occupational and Environmental Medicine, 69 (2), (pp. 99-106) (8 p.).
Smit, L.A., Kogevinas, M., Antó, J., Bouzigon, E., González, J.R., Le Moual, N., Kromhout, J., Carsin, A., Pin, I., Jarvis, D., Vermeulen, R.C.H., Janson, C., Heinrich, J., Gut, I., Lathrop, M., Valverde, M.A., Demenais, F. & Kauffmann, F. (2012). Transient receptor potential genes, smoking, occupational exposures and cough in adults. Respiratory Research, 13 (1), (pp. 26) (1 p.).
  Articles - 2011
Dumas, O., Smit, L.A., Pin, I., Kromhout, H., Siroux, V., Nadif, R., Vermeulen, R., Heederik, D., Hery, M., Choudat, D., Kauffmann, F. & le Moual, N. (2011). Do young adults with childhood asthma avoid occupational exposures at first hire?. European Respiratory Journal, 37 (5), (pp. 1043-1049) (7 p.).
Smit, L.A., Heederik, D., Doekes, G., Koppelman, G.H., Bottema, R.W.B., Postma, D.S. & Wouters, I.M. (2011). Endotoxin exposure, CD14 and wheeze among farmers: a gene--environment interaction. Occupational and Environmental Medicine, 68 (11), (pp. 826-831) (6 p.).
Smit, L.A., Bouzigon, E., Bousquet, J., le Moual, N., Nadif, R., Pin, I., Lathrop, M., Demenais, F., Kauffmann, F. & Siroux, V. (2011). Mold allergen sensitization in adult asthma according to integrin β3 polymorphisms and Toll-like receptor 2/+596 genotype. Journal of Allergy and Clinical Immunology, 128 (1), (pp. 185-191.e7) (179 p.).
  Articles - 2010
Smit, L.A., Bouzigon, E., Pin, V., Siroux, V., Monier, F., Aschard, H., Bousquet, J., Gormand, F., Just, J., le Moual, N., Nadif, R., Scheinmann, P., Vervloet, D., Lathrop, M., Demenais, F. & Kauffmann, F. (2010). 17q21 variants modify the association between early respiratory infections and asthma. European Respiratory Journal, 36 (1), (pp. 57-64) (8 p.).
Cantero-Recasens, G., Gonzalez, J.R., Fandos, C., Duran-Tauleria, E., Smit, L.A., Kauffmann, F., Anto, J.M. & Valverde, M.A. (2010). Loss of function of transient receptor potential vanilloid 1 (TRPV1) genetic variant is associated with lower risk of active childhood asthma. Journal of Biological Chemistry, 285 (36), (pp. 27532-27535) (4 p.).
Smit, L.A., Heederik, D., Doekes, G., Lammers, J.W.J. & Wouters, I.M. (2010). Occupational endotoxin exposure reduces the risk of atopic sensitization but increases the risk of bronchial hyperresponsiveness. International Archives of Allergy and Immunology, 152 (2), (pp. 151-158) (8 p.).
  Articles - 2009
van Rooy, F.G., Smit, L.A., Houba, R., Zaat, V.A., Rooijackers, J.M. & Heederik, D.J.J. (2009). A cross-sectional study of lung function and respiratory symptoms among chemical workers producing diacetyl for food flavourings. Occupational and Environmental Medicine, 66 (2), (pp. 105-110) (6 p.).
Douwes, J., Smit, L.A. & Heederik, D.J.J. (2009). Beschermende effecten van het opgroeien en werken op een boerderij op de ontwikkeling van atopische ziekten. Nederlands Tijdschrift voor Allergie, 9 (1), (pp. 3-15) (13 p.).
Smit, L.A., Siroux, V., Bouzigon, E., Oryszczyn, M.P., Lathrop, M., Demenais, F. & Kauffmann, F. (2009). CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. American Journal of Respiratory and Critical Care Medicine, 179 (5), (pp. 363-368) (5 p.).
Smit, L.A., Heederik, D.J.J., Doekes, G., Krop, E.J.M., Rijkers, G.T. & Wouters, I.M. (2009). Ex vivo cytokine release reflects sensitivity to occupational endotoxin exposure. European Respiratory Journal, 34 (4), (pp. 795-802) (8 p.).
Smit, L.A., Heederik, D.J.J., Doekes, G. & Wouters, I.M. (2009). Exhaled nitric oxide in endotoxin-exposed adults: effect modification by smoking and atopy. Occupational and Environmental Medicine, 66 (4), (pp. 251-255) (5 p.).
Smit, L.A., Wouters, I.M., Heederik, D. & Douwes, J. (2009). Gezondheidseffecten van blootstelling aan endotoxine. Een overzicht en de relevantie voor de veterinaire praktijk. Tijdschrift voor Diergeneeskunde, 134 (20), (pp. 840-846) (7 p.).
  Articles - 2008
Spaan, S., Smit, L.A., Eduard, W., Larsson, L., Arts, H.J., Wouters, I.M. & Heederik, D. (2008). Endotoxin Exposure in Sewage Treatment Workers: Investigation of Exposure Variability and Comparison of Analytical Techniques. Annals of Agricultural and Environmental Medicine, 15 (2), (pp. 251-261) (10 p.).
Smit, L.A., Heederik, D., Doekes, G., Blom, C., van Zweden, I. & Wouters, I.M. (2008). Exposure-response analysis of allergy and respiratory symptoms in endotoxin-exposed adults. European Respiratory Journal, 31 (6), (pp. 1241-1248) (8 p.).
  Articles - 2007
Smit, L.A., Bongers, S.I.M., Ruven, H.J., Rijkers, G.T., Wouters, I.M., Heederik, D.J.J., Omland, O. & Sigsgaard, T. (2007). Atopy and new-onset asthma in young Danish farmers in the Netherlands. Clinical and Experimental Allergy, 37 (11), (pp. 1602-1608) (7 p.).
van Rooy, F.G., Rooyackers, J.M., Prokop, W.M., Houba, R., Smit, L.A. & Heederik, D.J.J. (2007). Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. American Journal of Respiratory and Critical Care Medicine, 176 (5), (pp. 498-504) (7 p.).
Smit, L.A., Zuurbier, M., Doekes, G., Wouters, I.M., Heederik, D.J.J. & Douwes, J. (2007). Hay fever and asthma symptoms in conventional and organic farmers in the Netherlands. Occupational and Environmental Medicine, 64 (2), (pp. 101-107) (7 p.).
  Articles - 2006
Smit, L.A., Wouters, I.M., Hobo, M.M., Eduard, W., Doekes, G. & Heederik, D.J.J. (2006). Agricultural seed dust as a potential cause of organic dust toxic syndrome. Occupational and Environmental Medicine, 63 (1), (pp. 59-67) (9 p.).
Visser, M.J., Spaan, S., Arts, H.J., Smit, L.A. & Heederik, D.J.J. (2006). Influence of different cleaning practices on endotoxin exposure at sewage treatment plants. Annals of Occupational Hygiene, 50 (7), (pp. 731-736) (6 p.).
  Articles - 2005
Smit, L.A., Spaan, S. & Heederik, D.J.J. (2005). Endotoxin exposure and symptoms in wastewater treatment workers. American Journal of Industrial Medicine, 48 (1), (pp. 30-39) (9 p.).
  Articles - 2003
Smit, Lidwien A M, van-Wendel-de-Joode, Berna N, Heederik, Dick, Peiris-John, Roshini J & van der Hoek, Wim (2003). Neurological symptoms among Sri Lankan farmers occupationally exposed to acetylcholinesterase-inhibiting insecticides. American Journal of Industrial Medicine, 44 (3), (pp. 254-264) (11 p.). Copyright 2003 Wiley-Liss, Inc..
  Articles - 2002
Peiris-John, Roshini Janet, Ruberu, Dawala Kusuma, Wickremasinghe, Ananda Rajitha, Smit, Lidwien Ann Marie & van der Hoek, Wim (2002). Effects of occupational exposure to organophosphate pesticides on nerve and neuromuscular function. Journal of Occupational and Environmental Medicine, 44 (4), (pp. 352-7) (6 p.).
Eddleston, M, Karalliedde, L, Buckley, N, Fernando, R, Hutchinson, G, Isbister, G, Konradsen, F, Murray, D, Piola, JC, Senanyake, N, Sheriff, R, Singh, S, Siwach, SB & Smit, L (12.10.2002). Pesticide poisoning in the developing world - a minimum pesticides list. The Lancet, 360 (9340), (pp. 1163-1167) (5 p.).
  Reports - 2012
Uijt de Haag, P.A.M., Bellamy, L.J., Burdorf, A., Ter burg, W., Eysink, P., Heederik, D.J.J., Klein Entink, R.H., Manuel, H.J., Papazoglou, I.A., Pronk, A., Smit, L.A., Tielemans, E. & Timmerman, J. (2012). Occupational health or occupational safety: which impact is larger?. (121 p.). Bilthoven: Rijksinstituut voor Volksgezondheid en Milieu.
  Reports - 2011
Heederik, D., IJzermans, C.J., Opstal - van Winden, A.W.J., Smit, L.A., Wouters, I.M., Hooiveld, M., van der Sman, F., Spreeuwenberg, P.P.M., de Bruin, A. & Rotterdam, B. (2011). Mogelijke effecten van intensieve veehouderij op de gezondheid van omwonenden. (204 p.). Utrecht: IRAS, Nivel, RIVM.
  Doctoral thesis 1 (Research UU / Graduation UU) - 2008
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Completed projects

Project:
VGO: Livestock farming and neighbouring residents' health 01.01.2013 to 01.01.2017
General project description

In the Netherlands, there is an ongoing debate regarding environmental health risks of exposures from livestock farming, in particular from swine and poultry farms. Residents of many (new) urban areas, located at close proximity from commercial farming activities, usually less than a few hundreds meters to a few kilometers, may be exposed to potentially harmful infectious and resistant microorganisms, gases, and dust particles containing toxins. There is little scientific information about health risks for neighboring residents of livestock farms, but the available literature suggests several potential community health risks, like zoonoses and respiratory health effects. The overall objective of the VGO study is to investigate whether environmental exposure to livestock farm emissions in the Netherlands poses a health risk among neighbouring residents. 

 
Role Co-promotor
Individual project description

Project leader of two work packages (Astma/COPD and Data Management). 

Funding
External funding: Ministry of Economic Affairs; Ministry of Health; Lung Foundation
Project members UU
Project:
Occupational contact dermatitis in the construction industry 01.10.2010 to 01.10.2014
General project description

Construction workers are at a high risk for developing skin disorders as a result of exposure to a wide variety of allergens and irritants. The social and economic impact of occupational contact dermatitis is high, because prognosis is poor, and changing jobs is sometimes the only option for affected workers. Besides exposure to irritants and allergens, individual susceptibility may influence the risk to develop occupational contact dermatitis. In spite of the impact and high prevalence of contact dermatitis in various occupations, actions to reduce the risk of skin disorders in the construction industry have thus far been restricted to a few hazardous agents. This study investigates risk factors for occupational contact dermatitis in the construction industry at large. New insights in risk factors will be used to develop tools that will help to reduce the burden of skin disease among construction workers. 

 
Role Co-promotor Funding
External funding: Arbouw
Project members UU
Project:
CLEAR; Climate change, environmental contaminants and reproductive health 01.04.2010 to 01.04.2014
General project description

This research project investigates the possible impact of global climate change on reproductive health in Arctic and three local European populations. The key questions to be addressed are, first, how may climate change impact on human exposure to widespread environmental contaminants and, second, how may contaminants impact on occurrence of reproductive disorders as sensitive indicators of health.


To provide affirmative answers to these questions the project will


(i) identify and describe mechanisms by which a changing climate may affect the exposure of arctic and other human populations to contaminants through change in chemical use and emissions, delivery to the arctic ecosystem as well as processing within the arctic physical environment and human food chain. This work relies on modeling of existing data.


(ii) expand the existing knowledge database on human exposure to polybrominated diphenylethers, perfluorinated surfactants and phthalates by analyses of 1000 biobanked serum samples collected in the EU FP5 programme INUENDO


(iii) increase the limited knowledge on links between human exposure to contaminants and reproductive health. This work relies on a large existing parent-child-cohort, where a follow-up survey provide new data that are fed into risk assessment


(iv) perform reviews of experimental and epidemiological literature to identify critical reproductive effects and exposure response data for the selected compounds as input to the risk assesment


(v) integrate data on relative climate induced changes in contaminant mobility and distribution and links between contaminant exposure and reproductive health into a risk evaluation providing insight into possible future risk scenarios related to global climate change.

 
Role Supervisor Funding
EU grant
Project members UU
Project:
IAGO: Gene-environment interactions in occupational asthma 01.01.2010 to 01.01.2014
General project description

HLA is a principal candidate gene region for occupational asthma. Recently, HLA-DQ emerged from genome-wide association studies of late-onset asthma. The aim of this study is to further elucidate the role of HLA class II in adult-onset asthma, by taking occupational exposure into account.

 
Role Project Leader & Researcher
Individual project description

Multi-center study on HLA variants, occupational exposure and adult-onset asthma.

Funding
External funding: Agence Nationale de Recherche (ANR)
Project members UU
Gegenereerd op 2017-11-18 01:50:51

Course coordinator of lab course Environmental Health (ENVL1), University College Utrecht.

Gegenereerd op 2017-11-18 01:50:51
Additional functions and activities
  • European Respiratory Society, Long-range planning committee of Occupation and Epidemiology Assembly (2015-2018).
  • Respiratory Research, Editorial Board Member (2016 - present).
  • Scientifica, Editorial Board Member (2012 - present).
Gegenereerd op 2017-11-18 01:50:51
Full name
dr. ir. L.A. Smit Contact details
Nieuw Gildestein

Yalelaan 2
Room 3.12
3584 CM  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 8696
Phone number (department) +31 30 253 9494
Nieuw Gildestein

Bolognalaan 50
Room 3.64
3584 CJ  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 8696
Postal address
Postbus 80.178
3508 TD    UTRECHT
The Netherlands
Availability
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Gegenereerd op 2017-11-18 01:50:51
Last updated 10.11.2017