Highlighted publications
ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2004). A model for human ventricular tissue. American Journal of Physiology, 286, 1573-1589.
Mähönen, A. P.
, ten Tusscher, K., Siligato, R., Smetana, O.
, Díaz-Triviño, S., Salojärvi, J., Wachsman, G.
, Prasad, K., Heidstra, R., & Scheres, B. (2014).
PLETHORA gradient formation mechanism separates auxin responses.
Nature,
515(7525), 125-9.
https://doi.org/10.1038/nature13663ten Tusscher, K. H. W. J., & Panfilov, A. V. (2006).
Alternans and spiral breakup in a human ventricular tissue model.
American Journal of Physiology-Heart and Circulatory Physiology,
291(3), H1088-1100.
https://doi.org/10.1152/ajpheart.00109.2006 van den Berg, T., Korver, R. A., Testerink, C.
, & ten Tusscher, K. (2016).
Modeling halotropism: a key role for root tip architecture and reflux loop remodeling in redistributing auxin.
Development (Cambridge, England),
143(18), 3350-62.
https://doi.org/10.1242/dev.135111https://dspace.library.uu.nl/bitstream/handle/1874/346835/Modeling.pdf?sequence=1
Publications
2024
Scholarly publications
Eswaran, G., Zhang, X.
, Rutten, J. P., Han, J., Iida, H., López Ortiz, J., Mäkilä, R., Wybouw, B., Planterose Jiménez, B., Vainio, L., Porcher, A., Leal Gavarron, M., Zhang, J., Blomster, T., Wang, X., Dolan, D., Smetana, O., Brady, S. M., Kucukoglu Topcu, M., ... Mähönen, A. P. (2024).
Identification of cambium stem cell factors and their positioning mechanism.
Science (New York, N.Y.),
386(6722), 646-653.
https://doi.org/10.1126/science.adj8752Garcia Gomez, M., & ten Tusscher, K. (2024).
Computational Root Biology: Illuminating Patterning and Growth Decisions. In
Plant Roots: The Hidden Half (pp. 499-514). CRC Press.
https://doi.org/10.1201/b23126-40 Janacek, D. P., Kolb, M., Schulz, L., Mergner, J., Kuster, B., Glanc, M., Friml, J.
, ten Tusscher, K., Schwechheimer, C., & Hammes, U. Z. (2024).
Transport properties of canonical PIN-FORMED proteins from Arabidopsis and the role of the loop domain in auxin transport.
Developmental Cell,
59(24), 3259-3271.e4.
https://doi.org/10.1016/j.devcel.2024.09.020https://research-portal.uu.nl/ws/files/248638643/1-s2.0-S1534580724005690-main.pdfVan Den Herik, B., Bergonzi, S., Li, Y., Bachem, C. W.
, & Ten Tusscher, K. H. (2024).
A coordinated switch in sucrose and callose metabolism enables enhanced symplastic unloading in potato tubers.
Quantitative Plant Biology,
5, Article e4.
https://doi.org/10.1017/qpb.2024.4https://research-portal.uu.nl/ws/files/240863037/a-coordinated-switch-in-sucrose-and-callose-metabolism-enables-enhanced-symplastic-unloading-in-potato-tubers.pdf Noordijk, B.
, Garcia Gomez, M. L., ten Tusscher, K. H. W. J., de Ridder, D., van Dijk, A. D. J., & Smith, R. W. (2024).
The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology.
Frontiers in Systems Biology,
4, Article 1407994.
https://doi.org/10.3389/fsysb.2024.1407994https://research-portal.uu.nl/ws/files/237784859/fsysb-04-1407994.pdf2023
Scholarly publications
Wang, Q., De Gernier, H., Duan, X., Xie, Y., Geelen, D., Hayashi, K.-I., Xuan, W., Geisler, M.
, Ten Tusscher, K., Beeckman, T., & Vanneste, S. (2023).
GH3-mediated auxin inactivation attenuates multiple stages of lateral root development.
New Phytologist,
240(5), 1900-1912.
https://doi.org/10.1111/nph.19284https://dspace.library.uu.nl/bitstream/handle/1874/434543/New_Phytologist_-_2023_-_Wang_-_GH3_mediated_auxin_inactivation_attenuates_multiple_stages_of_lateral_root_development.pdf?sequence=1Chen, S., ten Tusscher, K. H. W. J., Sasidharan, R., Dekker, S. C., & de Boer, H. J. (2023).
Parallels between drought and flooding: An integrated framework for plant eco-physiological responses to water stress.
Plant-Environment Interactions,
4(4), 175-187.
https://doi.org/10.1002/pei3.10117https://dspace.library.uu.nl/bitstream/handle/1874/430876/Plant_Enviro_Interactions_-_2023_-_Chen.pdf?sequence=1 2022
Scholarly publications
2021
Scholarly publications
Autran, D., Bassel, G. W., Chae, E., Ezer, D., Ferjani, A., Fleck, C., Hamant, O., Hartmann, F. P., Jiao, Y., Johnston, I. G., Kwiatkowska, D., Lim, B. L., Mahönen, A. P., Morris, R. J.
, Mulder, B. M., Nakayama, N., Sozzani, R., Strader, L. C.
, Ten Tusscher, K., ... Wolf, S. (2021).
What is quantitative plant biology? Quantitative Plant Biology,
2, 1-16. Article e10.
https://doi.org/10.1017/qpb.2021.8https://dspace.library.uu.nl/bitstream/handle/1874/413686/what_is_quantitative_plant_biology.pdf?sequence=1van den Berg, T., Yalamanchili, K., de Gernier, H.
, Santos Teixeira, J., Beeckman, T., Scheres, B.
, Willemsen, V., & Ten Tusscher, K. (2021).
A reflux-and-growth mechanism explains oscillatory patterning of lateral root branching sites.
Developmental Cell,
56(15), 2176-2191.e10.
https://doi.org/10.1016/j.devcel.2021.07.005https://dspace.library.uu.nl/bitstream/handle/1874/413557/1_s2.0_S153458072100561X_main.pdf?sequence=1 2020
Scholarly publications
Moret, B., Marhava, P., Aliaga Fandino, A. C., Hardtke, C. S.
, & ten Tusscher, K. H. W. (2020).
Local auxin competition explains fragmented differentiation patterns.
Nature Communications,
11(1), Article 2965.
https://doi.org/10.1038/s41467-020-16803-7https://dspace.library.uu.nl/bitstream/handle/1874/409808/s41467_020_16803_7.pdf?sequence=1Salvi, E.
, Rutten, J. P., Di Mambro, R., Polverari, L., Licursi, V., Negri, R., Dello Ioio, R., Sabatini, S.
, & Ten Tusscher, K. (2020).
A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana.
Developmental Cell,
53(4), 431-443.e23.
https://doi.org/10.1016/j.devcel.2020.04.004https://dspace.library.uu.nl/bitstream/handle/1874/409807/1_s2.0_S1534580720302719_main.pdf?sequence=1Korver, R. A.
, van den Berg, T., Meyer, A. J., Galvan-Ampudia, C. S.
, Ten Tusscher, K. H. W. J., & Testerink, C. (2020).
Halotropism requires Phospholipase Dζ1-mediated modulation of cellular polarity of auxin transport carriers.
Plant, Cell and Environment,
43(1), 143-158.
https://doi.org/10.1111/pce.13646https://dspace.library.uu.nl/bitstream/handle/1874/392086/Korver_et_al_2020_Plant_Cell_Environment.pdf?sequence=12019
Scholarly publications
2018
Scholarly publications
2017
Scholarly publications
2016
Scholarly publications
van den Berg, T., Korver, R. A., Testerink, C.
, & ten Tusscher, K. (2016).
Modeling halotropism: a key role for root tip architecture and reflux loop remodeling in redistributing auxin.
Development (Cambridge, England),
143(18), 3350-62.
https://doi.org/10.1242/dev.135111https://dspace.library.uu.nl/bitstream/handle/1874/346835/Modeling.pdf?sequence=1 Hogeweg, P.
, ten Tusscher, K. H. W. J., Davis, GK., Patel, NH., Peel, A., Akam, M., Couso, JP., Budd, GE., Seaver, EC., Minelli, A., Fusco, G., Tautz, D., Jacobs, DK., Hughes, NC., Fitz-Gibbon, ST., Winchell, CJ., Blair, SS., Wanninger, A., Kristof, A., ... Ruddle, FH. (2016).
In silico evo-devo: reconstructing stages in the evolution of animal segmentation.
EvoDevo,
7(1), 14.
https://doi.org/10.1186/s13227-016-0052-8https://dspace.library.uu.nl/bitstream/handle/1874/345640/In_silico.pdf?sequence=12015
Scholarly publications
2014
Scholarly publications
Mähönen, A. P.
, ten Tusscher, K., Siligato, R., Smetana, O.
, Díaz-Triviño, S., Salojärvi, J., Wachsman, G.
, Prasad, K., Heidstra, R., & Scheres, B. (2014).
PLETHORA gradient formation mechanism separates auxin responses.
Nature,
515(7525), 125-9.
https://doi.org/10.1038/nature136632013
Scholarly publications
Ten Tusscher, K. H. (2013). Mechanisms and constraints shaping the evolution of body plan segmentation. European physical journal. E, Soft Matter, 36(5), 54.
van Berkel, K., de Boer, R. J., Scheres, B. J. G., & ten Tusscher, K. H. W. J. (2013). Polar auxin transport: models and mechanisms. Development (Rome), 140, 2253-2268.
ten Tusscher, K. H. W. J. (2013). Mechanisms and constrainsts shaping the evolution of body plan segmentation. European physical journal. E, Soft Matter, 36, 54.
2011
Scholarly publications
ten Tusscher, K. H. W. J., & Scheres, B. J. G. (2011). Joining forces: feedback and integration in plant development. Current Opinion in Genetics & Development, 21, 799-805.
ten Tusscher, K. H. W. J., & Hogeweg, P. (2011). Evolution of networks for body plan patterning; interplay of modularity robustness and evolvability. PLoS Computational Biology, 7, e1002208.
2010
Scholarly publications
ten Tusscher, K. H. W. J., & Hogeweg, P. (2010). The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation. Experimental Physiology, 9, 159.
2009
Scholarly publications
Ten Tusscher, K. H. W. J., Mourad, A., Nash, M. P., Clayton, R. H., Bradley, C. P., Paterson, D. J., Hren, R., Hayward, M.
, Panfilov, A. V., & Taggart, P. (2009).
Organization of ventricular fibrillation in the human heart: Experiments and models.
Experimental Physiology,
94(5), 553-562.
https://doi.org/10.1113/expphysiol.2008.044065 ten Tusscher, K. H. W. J., & Hogeweg, P. (2009). The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation. BMC Evolutionary Biology, 9, 159.
2008
Scholarly publications
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2008). Modelling of the ventricular conduction system. Progress in Biophysics & Molecular Biology, 96, 152-170 DOI. MEDLINE.
Keldermann, R. H., ten Tusscher, K. H. W. J., Nash, M. P., Hren, R., Taggart, P., & Panfilov, A. V. (2008). Effect of heterogeneous APD restitution on VF organization in a model of the human ventricles. American Journal of Physiology-Heart and Circulatory Physiology, 294, H764-H774 DOI. MEDLINE.
Keldermann, R. H., ten Tusscher, K. H. W. J., Nash, M. P., Bradley, C. P., Hren, R., Taggart, P., & Panfilov, A. V. (2008). A computational study of mother rotor VF in the human ventricles. American Journal of Physiology-Heart and Circulatory Physiology, 0, 0-DOI. MEDLINE.
2007
Scholarly publications
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2007). Influence of diffuse fibrosis on wave propagation in human ventricular tissue. Europace, 9, 138-145.
2006
Scholarly publications
Ten Tusscher, K. H. W. J., & Panfilov, A. V. (2006).
Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions.
Physics in Medicine and Biology,
51(23), 6141-6156.
https://doi.org/10.1088/0031-9155/51/23/014 Ten Tusscher, K. H. W. J., Bernus, O., Hren, R.
, & Panfilov, A. V. (2006).
Comparison of electrophysiological models for human ventricular cells and tissues.
Progress in Biophysics & Molecular Biology,
90(1-3), 326-345.
https://doi.org/10.1016/j.pbiomolbio.2005.05.015 ten Tusscher, K. H. W. J., & Panfilov, A. V. (2006).
Alternans and spiral breakup in a human ventricular tissue model.
American Journal of Physiology-Heart and Circulatory Physiology,
291(3), H1088-1100.
https://doi.org/10.1152/ajpheart.00109.2006 2005
Scholarly publications
Ten Tusscher, K. H. W. J., & Panfilov, A. V. (2005).
Wave propagation in excitable media with randomly distributed obstacles.
Multiscale Modeling and Simulation,
3(2), 265-282.
https://doi.org/10.1137/030602654 ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2005). Comments on "A model for human ventricular tissue". American Journal of Physiology, 288, H253-H254.
2004
Scholarly publications
ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2004). A model for human ventricular tissue. American Journal of Physiology, 286, 1573-1589.
ten Tusscher, K. H. W. J. (2004). Spiral wave dynamics and ventricular arrhythmias. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Universiteit Utrecht.
2003
Scholarly publications
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2003). Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. American Journal of Physiology, 284, 542-548.
2002
Scholarly publications
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2002). Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. American Journal of Physiology-Heart and Circulatory Physiology.
2000
Scholarly publications