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Prof. dr. K.H.W.J. (Kirsten) ten Tusscher

Professor 
Science
Biology
Biodynamics and Biocomplexity
Theoretical Biology
Theoretical Biology
 
Science
Biology
Environmental Biology
Experimental and Computational Plant Development
Experimental and Computational Plant Development
Hugo R. Kruytgebouw
Padualaan 8
Kamer Z.305
3584 CH Utrecht

Prof. dr. K.H.W.J. (Kirsten) ten Tusscher

Professor
Theoretical Biology
Experimental and Computational Plant Development
k.h.w.j.tentusscher@uu.nl
Profile Publications Prizes Teaching Ancillary activities Contact
Profile Publications Prizes Teaching Ancillary activities Contact
Areas of expertise
Skills
Research areas

Highlighted publications

ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2004). A model for human ventricular tissue. American Journal of Physiology, 286, 1573-1589.
Mähönen, A. P., ten Tusscher, K., Siligato, R., Smetana, O., Díaz-Triviño, S., Salojärvi, J., Wachsman, G., Prasad, K., Heidstra, R., & Scheres, B. (2014). PLETHORA gradient formation mechanism separates auxin responses. Nature, 515(7525), 125-9. https://doi.org/10.1038/nature13663
Laskowski, M., & Ten Tusscher, K. H. (2017). Periodic lateral root priming: What makes it tick? Plant Cell, 29(3), 432-444. https://doi.org/10.1105/tpc.16.00638
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2006). Alternans and spiral breakup in a human ventricular tissue model. American Journal of Physiology-Heart and Circulatory Physiology, 291(3), H1088-1100. https://doi.org/10.1152/ajpheart.00109.2006
van den Berg, T., Korver, R. A., Testerink, C., & ten Tusscher, K. (2016). Modeling halotropism: a key role for root tip architecture and reflux loop remodeling in redistributing auxin. Development (Cambridge, England), 143(18), 3350-62. https://doi.org/10.1242/dev.135111

Publications

2024

Scholarly publications

Van Den Herik, B., Bergonzi, S., Li, Y., Bachem, C. W., & Ten Tusscher, K. H. (2024). A coordinated switch in sucrose and callose metabolism enables enhanced symplastic unloading in potato tubers. Quantitative Plant Biology, 5, Article e4. https://doi.org/10.1017/qpb.2024.4
Noordijk, B., Garcia Gomez, M. L., ten Tusscher, K. H. W. J., de Ridder, D., van Dijk, A. D. J., & Smith, R. W. (2024). The rise of scientific machine learning: a perspective on combining mechanistic modelling with machine learning for systems biology. Frontiers in Systems Biology, 4, Article 1407994. https://doi.org/10.3389/fsysb.2024.1407994
García-Gómez, M. L., & ten Tusscher, K. (2024). Multi-scale mechanisms driving root regeneration: From regeneration competence to tissue repatterning. Plant Journal, 119(3), 1183-1196. https://doi.org/10.1111/tpj.16860

2023

Scholarly publications

Wang, Q., De Gernier, H., Duan, X., Xie, Y., Geelen, D., Hayashi, K.-I., Xuan, W., Geisler, M., Ten Tusscher, K., Beeckman, T., & Vanneste, S. (2023). GH3-mediated auxin inactivation attenuates multiple stages of lateral root development. New Phytologist, 240(5), 1900-1912. https://doi.org/10.1111/nph.19284
https://dspace.library.uu.nl/bitstream/handle/1874/434543/New_Phytologist_-_2023_-_Wang_-_GH3_mediated_auxin_inactivation_attenuates_multiple_stages_of_lateral_root_development.pdf?sequence=1
Chen, S., ten Tusscher, K. H. W. J., Sasidharan, R., Dekker, S. C., & de Boer, H. J. (2023). Parallels between drought and flooding: An integrated framework for plant eco-physiological responses to water stress. Plant-Environment Interactions, 4(4), 175-187. https://doi.org/10.1002/pei3.10117

2022

Scholarly publications

Van Schijndel, L., Snoek, B. L., & Ten Tusscher, K. (2022). Embodiment in distributed information processing: Solid plants versus liquid ant colonies. Quantitative Plant Biology, 3, 1-7. Article e27. https://doi.org/10.1017/qpb.2022.22
van Schijndel, L., Snoek, B. L., & ten Tusscher, K. (2022). Author comment: Embodiment in distributed information processing: “Solid” plants versus “liquid” ant colonies — R0/PR1. Quantitative Plant Biology, Article 27. https://doi.org/10.1017/qpb.2022.22.pr1
Santos Teixeira, J., van den Berg, T., & Ten Tusscher, K. (2022). Complementary roles for auxin and auxin signalling revealed by reverse engineering lateral root stable prebranch site formation. Development (Cambridge, England), 149(22), 1-20. Article dev200927. https://doi.org/10.1242/dev.200927
van den Herik, B., & ten Tusscher, K. (2022). Undirected Sucrose Efflux Mitigation by the FT-Like SP6A Preferentially Enhances Tuber Resource Partitioning. Frontiers in Plant Science, 13, 1-14. Article 817909. https://doi.org/10.3389/fpls.2022.817909
Rutten, J., van den Berg, T., & Ten Tusscher, K. (2022). Modeling Auxin Signaling in Roots: Auxin Computations. Cold Spring Harbor perspectives in biology, 14(2), 1-19. Article a040089. https://doi.org/10.1101/cshperspect.a040089

2021

Scholarly publications

Vroomans, R. M. A., & Ten Tusscher, K. H. W. J. (2021). Modeling Evolution of Developmental Gene Regulatory Networks. In L. Nuño de la Rosa, & G. B. Müller (Eds.), Evolutionary Developmental Biology: A Reference Guide (1 ed., pp. 1013-1029). Springer. https://doi.org/10.1007/978-3-319-32979-6_118
Morris, R. J., & Ten Tusscher, K. H. (2021). Quantitative plant biology—Old and new. Quantitative Plant Biology, 2, 1-5. Article e8. https://doi.org/10.1017/qpb.2021.4
Autran, D., Bassel, G. W., Chae, E., Ezer, D., Ferjani, A., Fleck, C., Hamant, O., Hartmann, F. P., Jiao, Y., Johnston, I. G., Kwiatkowska, D., Lim, B. L., Mahönen, A. P., Morris, R. J., Mulder, B. M., Nakayama, N., Sozzani, R., Strader, L. C., Ten Tusscher, K., ... Wolf, S. (2021). What is quantitative plant biology? Quantitative Plant Biology, 2, 1-16. Article e10. https://doi.org/10.1017/qpb.2021.8
Rutten, J. P., & Ten Tusscher, K. H. (2021). Bootstrapping and pinning down the root meristem; the auxin-PLT-ARR network unites robustness and sensitivity in meristem growth control. International Journal of Molecular Sciences, 22(9), 1-22. Article 4731. https://doi.org/10.3390/ijms22094731
van den Berg, T., Yalamanchili, K., de Gernier, H., Santos Teixeira, J., Beeckman, T., Scheres, B., Willemsen, V., & Ten Tusscher, K. (2021). A reflux-and-growth mechanism explains oscillatory patterning of lateral root branching sites. Developmental Cell, 56(15), 2176-2191.e10. https://doi.org/10.1016/j.devcel.2021.07.005
https://dspace.library.uu.nl/bitstream/handle/1874/413557/1_s2.0_S153458072100561X_main.pdf?sequence=1
van den Herik, B., Bergonzi, S., Bachem, C. W. B., & ten Tusscher, K. (2021). Modelling the physiological relevance of sucrose export repression by an Flowering Time homolog in the long-distance phloem of potato. Plant Cell and Environment, 44(3), 792-806. https://doi.org/10.1111/pce.13977
ten Tusscher, K. H. (2021). What remains of the evidence for auxin feedback on PIN polarity patterns? Plant Physiology, 186(2), 804-807. https://doi.org/10.1093/PLPHYS/KIAB118

2020

Scholarly publications

Moret, B., Marhava, P., Aliaga Fandino, A. C., Hardtke, C. S., & ten Tusscher, K. H. W. (2020). Local auxin competition explains fragmented differentiation patterns. Nature Communications, 11(1), Article 2965. https://doi.org/10.1038/s41467-020-16803-7
Salvi, E., Rutten, J. P., Di Mambro, R., Polverari, L., Licursi, V., Negri, R., Dello Ioio, R., Sabatini, S., & Ten Tusscher, K. (2020). A Self-Organized PLT/Auxin/ARR-B Network Controls the Dynamics of Root Zonation Development in Arabidopsis thaliana. Developmental Cell, 53(4), 431-443.e23. https://doi.org/10.1016/j.devcel.2020.04.004
Boer, M. D., Santos Teixeira, J., & Ten Tusscher, K. H. (2020). Modeling of Root Nitrate Responses Suggests Preferential Foraging Arises From the Integration of Demand, Supply and Local Presence Signals. Frontiers in Plant Science, 11, Article 708. https://doi.org/10.3389/fpls.2020.00708
Korver, R. A., van den Berg, T., Meyer, A. J., Galvan-Ampudia, C. S., Ten Tusscher, K. H. W. J., & Testerink, C. (2020). Halotropism requires Phospholipase Dζ1-mediated modulation of cellular polarity of auxin transport carriers. Plant, Cell and Environment, 43(1), 143-158. https://doi.org/10.1111/pce.13646
Ten Tusscher, K. (2020). Of mice and plants: Comparative developmental systems biology. Developmental Biology, 460(1), 32-39. https://doi.org/10.1016/j.ydbio.2018.10.024
https://dspace.library.uu.nl/bitstream/handle/1874/407533/1_s2.0_S0012160618306122_main.pdf?sequence=1

2019

Scholarly publications

Weise, L. D., & Ten Tusscher, K. H. W. J. (2019). Discrete mechanical growth model for plant tissue. PLoS One, 14(8), Article e0221059. https://doi.org/10.1371/journal.pone.0221059
Rutten, J. P., & ten Tusscher, K. (2019). In Silico Roots: Room for Growth. Trends in Plant Science, 24(3), 250-262. https://doi.org/10.1016/j.tplants.2018.11.005
https://dspace.library.uu.nl/bitstream/handle/1874/384267/1_s2.0_S136013851830267X_main.pdf?sequence=1
Santos Teixeira, J. A., & ten Tusscher, K. H. (2019). The Systems Biology of Lateral Root Formation: Connecting the Dots. Molecular Plant, 12(6), 784-803. https://doi.org/10.1016/j.molp.2019.03.015

2018

Scholarly publications

Vroomans, R. M. A., Hogeweg, P., & ten Tusscher, K. H. W. J. (2018). Around the clock: Gradient shape and noise impact the evolution of oscillatory segmentation dynamics. EvoDevo, 9(1), Article 24. https://doi.org/10.1186/s13227-018-0113-2

2017

Scholarly publications

van den Berg, T., & ten Tusscher, K. H. (2017). Auxin information processing: partners and interactions beyond the usual suspects. International Journal of Molecular Sciences, 18(12), Article 2585. https://doi.org/10.3390/ijms18122585
Vroomans, R. M. A., & ten Tusscher, K. H. W. J. (2017). Modelling asymmetric somitogenesis: Deciphering the mechanisms behind species differences. Developmental Biology, 427(1), 21-34. https://doi.org/10.1016/j.ydbio.2017.05.010
Laskowski, M., & Ten Tusscher, K. H. (2017). Periodic lateral root priming: What makes it tick? Plant Cell, 29(3), 432-444. https://doi.org/10.1105/tpc.16.00638

2016

Scholarly publications

van den Berg, T., Korver, R. A., Testerink, C., & ten Tusscher, K. (2016). Modeling halotropism: a key role for root tip architecture and reflux loop remodeling in redistributing auxin. Development (Cambridge, England), 143(18), 3350-62. https://doi.org/10.1242/dev.135111
Kazbanov, I. V., ten Tusscher, K., & Panfilov, A. V. (2016). Effects of Heterogeneous Diffuse Fibrosis on Arrhythmia Dynamics and Mechanism. Scientific Reports, 6, Article 20835. https://doi.org/10.1038/srep20835
Hogeweg, P., ten Tusscher, K. H. W. J., Davis, GK., Patel, NH., Peel, A., Akam, M., Couso, JP., Budd, GE., Seaver, EC., Minelli, A., Fusco, G., Tautz, D., Jacobs, DK., Hughes, NC., Fitz-Gibbon, ST., Winchell, CJ., Blair, SS., Wanninger, A., Kristof, A., ... Ruddle, FH. (2016). In silico evo-devo: reconstructing stages in the evolution of animal segmentation. EvoDevo, 7(1), 14. https://doi.org/10.1186/s13227-016-0052-8

2015

Scholarly publications

Vroomans, R. M. A., Hogeweg, P., & ten Tusscher, K. H. W. J. (2015). Segment-Specific Adhesion as a Driver of Convergent Extension. PLoS Computational Biology, 11(2), Article e1004092. https://doi.org/10.1371/journal.pcbi.1004092
https://dspace.library.uu.nl/bitstream/handle/1874/324896/92.pdf?sequence=1

2014

Scholarly publications

Mähönen, A. P., ten Tusscher, K., Siligato, R., Smetana, O., Díaz-Triviño, S., Salojärvi, J., Wachsman, G., Prasad, K., Heidstra, R., & Scheres, B. (2014). PLETHORA gradient formation mechanism separates auxin responses. Nature, 515(7525), 125-9. https://doi.org/10.1038/nature13663

2013

Scholarly publications

Ten Tusscher, K. H. (2013). Mechanisms and constraints shaping the evolution of body plan segmentation. European physical journal. E, Soft Matter, 36(5), 54.
van Berkel, K., de Boer, R. J., Scheres, B. J. G., & ten Tusscher, K. H. W. J. (2013). Polar auxin transport: models and mechanisms. Development (Rome), 140, 2253-2268.
ten Tusscher, K. H. W. J. (2013). Mechanisms and constrainsts shaping the evolution of body plan segmentation. European physical journal. E, Soft Matter, 36, 54.

2011

Scholarly publications

ten Tusscher, K. H. W. J., & Scheres, B. J. G. (2011). Joining forces: feedback and integration in plant development. Current Opinion in Genetics & Development, 21, 799-805.
ten Tusscher, K. H. W. J., & Hogeweg, P. (2011). Evolution of networks for body plan patterning; interplay of modularity robustness and evolvability. PLoS Computational Biology, 7, e1002208.

2010

Scholarly publications

ten Tusscher, K. H. W. J., & Hogeweg, P. (2010). The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation. Experimental Physiology, 9, 159.

2009

Scholarly publications

Ten Tusscher, K. H. W. J., Mourad, A., Nash, M. P., Clayton, R. H., Bradley, C. P., Paterson, D. J., Hren, R., Hayward, M., Panfilov, A. V., & Taggart, P. (2009). Organization of ventricular fibrillation in the human heart: Experiments and models. Experimental Physiology, 94(5), 553-562. https://doi.org/10.1113/expphysiol.2008.044065
ten Tusscher, K. H. W. J., & Hogeweg, P. (2009). The role of genome and gene regulatory network canalization in the evolution of multi-trait polymorphisms and sympatric speciation. BMC Evolutionary Biology, 9, 159.

2008

Scholarly publications

ten Tusscher, K. H. W. J., & Panfilov, A. V. (2008). Modelling of the ventricular conduction system. Progress in Biophysics & Molecular Biology, 96, 152-170 DOI. MEDLINE.
Keldermann, R. H., ten Tusscher, K. H. W. J., Nash, M. P., Hren, R., Taggart, P., & Panfilov, A. V. (2008). Effect of heterogeneous APD restitution on VF organization in a model of the human ventricles. American Journal of Physiology-Heart and Circulatory Physiology, 294, H764-H774 DOI. MEDLINE.
Keldermann, R. H., ten Tusscher, K. H. W. J., Nash, M. P., Bradley, C. P., Hren, R., Taggart, P., & Panfilov, A. V. (2008). A computational study of mother rotor VF in the human ventricles. American Journal of Physiology-Heart and Circulatory Physiology, 0, 0-DOI. MEDLINE.

2007

Scholarly publications

Ten Tusscher, K. H. W. J., Hren, R., & Panfilov, A. V. (2007). Organization of ventricular fibrillation in the human heart. Circulation Research, 100(12), e87-101. https://doi.org/10.1161/CIRCRESAHA.107.150730
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2007). Influence of diffuse fibrosis on wave propagation in human ventricular tissue. Europace, 9, 138-145.

2006

Scholarly publications

Ten Tusscher, K. H. W. J., & Panfilov, A. V. (2006). Cell model for efficient simulation of wave propagation in human ventricular tissue under normal and pathological conditions. Physics in Medicine and Biology, 51(23), 6141-6156. https://doi.org/10.1088/0031-9155/51/23/014
Ten Tusscher, K. H. W. J., Bernus, O., Hren, R., & Panfilov, A. V. (2006). Comparison of electrophysiological models for human ventricular cells and tissues. Progress in Biophysics & Molecular Biology, 90(1-3), 326-345. https://doi.org/10.1016/j.pbiomolbio.2005.05.015
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2006). Alternans and spiral breakup in a human ventricular tissue model. American Journal of Physiology-Heart and Circulatory Physiology, 291(3), H1088-1100. https://doi.org/10.1152/ajpheart.00109.2006

2005

Scholarly publications

Ten Tusscher, K. H. W. J., & Panfilov, A. V. (2005). Wave propagation in excitable media with randomly distributed obstacles. Multiscale Modeling and Simulation, 3(2), 265-282. https://doi.org/10.1137/030602654
ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2005). Comments on "A model for human ventricular tissue". American Journal of Physiology, 288, H253-H254.

2004

Scholarly publications

ten Tusscher, K. H. W. J., Noble, D., Noble, P. J., & Panfilov, A. V. (2004). A model for human ventricular tissue. American Journal of Physiology, 286, 1573-1589.
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2004). Eikonal formulation of the minimal principle for scroll wave filaments. Physical Review Letters, 93(10), 1-4. Article 108106.
https://dspace.library.uu.nl/bitstream/handle/1874/15927/ten_tusscher_04_eikonal.pdf?sequence=2
ten Tusscher, K. H. W. J. (2004). Spiral wave dynamics and ventricular arrhythmias. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Universiteit Utrecht.

2003

Scholarly publications

ten Tusscher, K. H. W. J., & Panfilov, A. V. (2003). Influence of nonexcitable cells on spiral breakup in two-dimensional and three-dimensional excitable media. Physical Review. E, Statistical, nonlinear, and soft matter physics, 68, 062902-1-062902-4.
https://dspace.library.uu.nl/bitstream/handle/1874/14022/tusscher_03_influence.pdf?sequence=2
ten Tusscher, K. H. W. J., & Panfilov, A. V. (2003). Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. American Journal of Physiology, 284, 542-548.

2002

Scholarly publications

ten Tusscher, K. H. W. J., & Panfilov, A. V. (2002). Reentry in heterogeneous cardiac tissue described by the Luo-Rudy ventricular action potential model. American Journal of Physiology-Heart and Circulatory Physiology.

2000

Scholarly publications

ten Tusscher, K. H. W. J., ten Hagen, S., & Wiering, M. A. (2000). The influence of communication on the choice to behave cooperatively. In A. Feelders (Ed.), Proceedings of the Tenth Belgian-Dutch Conference on Machine Learning (pp. 39-46)
https://dspace.library.uu.nl/bitstream/handle/1874/20841/wiering_00_influence.pdf?sequence=2

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