Publications
2016
Scholarly publications
Sparidans, R. W., van Hoppe, S., Rood, J. J. M., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2016). Liquid chromatography-tandem mass spectrometric assay for the tyrosine kinase inhibitor afatinib in mouse plasma using salting-out liquid-liquid extraction. Journal of chromatography. B, 1012-1013, 118-123. https://doi.org/10.1016/j.jchromb.2016.01.025
2015
Scholarly publications
Kip, A. E., Rosing, H., Hillebrand, M. J. X., Castro, M. M., Gomez, M. A., Schellens, J. H. M., Beijnen, J. H., & Dorlo, T. P. C. (2015). Quantification of miltefosine in peripheral blood mononuclear cells by high-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, 998-999, 57-62. https://doi.org/10.1016/j.jchromb.2015.06.017
Vogel, C. J., Smit, M. A., Maddalo, G., Possik, P. A., Sparidans, R. W., van der Burg, S. H., Verdegaal, E. M., Heck, A. J. R., Samatar, A. A., Beijnen, J. H., Altelaar, A. F. M., & Peeper, D. S. (2015). Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell and Melanoma Research, 28(3), 307-317. https://doi.org/10.1111/pcmr.12364
Iusuf, D., Hendrikx, J. J. M. A., van Esch, A., van de Steeg, E., Wagenaar, E., Rosing, H., Beijnen, J. H., & Schinkel, A. H. (2015). Human OATP1B1, OATP1B3 and OATP1A2 can mediate the in vivo uptake and clearance of docetaxel. International Journal of Cancer, 136(1), 225-33. https://doi.org/10.1002/ijc.28970
Durmus, S., Sparidans, R. W., van Esch, A., Wagenaar, E., Beijnen, J. H., & Schinkel, A. H. (2015). Breast Cancer Resistance Protein (BCRP/ABCG2) and P-glycoprotein (P-GP/ABCB1) Restrict Oral Availability and Brain Accumulation of the PARP Inhibitor Rucaparib (AG-014699). Pharmaceutical Research, 32(1), 37-46. https://doi.org/10.1007/s11095-014-1442-z
Leijen, S., Burgers, S. A., Baas, P., Pluim, D., Tibben, M., van Werkhoven, E., Alessio, E., Sava, G., Beijnen, J. H., & Schellens, J. H. M. (2015). Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy. Investigational New Drugs, 33(1), 201-14. https://doi.org/10.1007/s10637-014-0179-1
Dubbelman, A-C., Rosing, H., Nijenhuis, C., Huitema, A. D. R., Mergui-Roelvink, M., Gupta, A., Verbel, D., Thompson, G., Shumaker, R., Schellens, J. H. M., & Beijnen, J. H. (2015). Pharmacokinetics and excretion of (14)C-lenvatinib in patients with advanced solid tumors or lymphomas. Investigational New Drugs, 33(1), 233-40. https://doi.org/10.1007/s10637-014-0181-7
Mehta, A. M., Van den Hoven, J. M., Rosing, H., Hillebrand, M. J. X., Nuijen, B., Huitema, A. D. R., Beijnen, J. H., & Verwaal, V. J. (2015). Stability of oxaliplatin in chloride-containing carrier solutions used in hyperthermic intraperitoneal chemotherapy. International Journal of Pharmaceutics, 479(1), 23-7. https://doi.org/10.1016/j.ijpharm.2014.12.025
Dolman, M. E. M., Westerhout, E. M., Hamdi, M., Schellens, J. H. M., Beijnen, J. H., & Sparidans, R. W. (2015). Liquid chromatography-tandem mass spectrometric assay for the PI3K/mTOR inhibitor GSK2126458 in mouse plasma and tumor homogenate. Journal of Pharmaceutical and Biomedical Analysis, 107, 403-408. https://doi.org/10.1016/j.jpba.2015.01.026
Kip, A. E., Balasegaram, M., Beijnen, J. H., Schellens, J. H. M., de Vries, P. J., & Dorlo, T. P. C. (2015). Systematic Review of Biomarkers To Monitor Therapeutic Response in Leishmaniasis. Antimicrobial Agents and Chemotherapy, 59(1), 1-14. https://doi.org/10.1128/AAC.04298-14
Aarts, F., Radhakishun, N. N. E., van Vliet, M., Geenen, R., von Rosenstiel, I. A., Hinnen, C., Beijnen, J., Brandjes, D. P. M., Diamant, M., & Gerdes, V. E. A. (2015). Gastric bypass may promote weight loss in overweight partners. Journal of the American Board of Family Medicine, 28(1), 90-96. https://doi.org/10.3122/jabfm.2015.01.140103
Professional publications
Dorlo, T. P. C., Balasegaram, M., Beijnen, J. H., De Vries, P. J., & Huitema, A. D. R. (2015). Translationele farmacokinetische modellering en simulatie om de duur van anticonceptie te bepalen na behandeling met miltefosine. Pharmaceutisch Weekblad, 150(22), 94-101.
2014
Scholarly publications
Lankheet, N. A. G., Knapen, L. M., Schellens, J. H. M., Beijnen, J. H., Steeghs, N., & Huitema, A. D. R. (2014). Plasma concentrations of tyrosine kinase inhibitors imatinib, erlotinib, and sunitinib in routine clinical outpatient cancer care. Therapeutic Drug Monitoring, 36(3), 326-334. https://doi.org/10.1097/FTD.0000000000000004
Mooiman, K. D., Maas-Bakker, R. F., Hendrikx, J. J. M. A., Bank, P. C. D., Rosing, H., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2014). The effect of complementary and alternative medicines on CYP3A4-mediated metabolism of three different substrates: 7-benzyloxy-4-trifluoromethyl-coumarin, midazolam and docetaxel. Journal of Pharmacy and Pharmacology, 66(6), 865-74. https://doi.org/10.1111/jphp.12208
Radhakishun, N., Blokhuis, C., van Vliet, M., von Rosenstiel, I., Weijer, O., Heymans, M., Beijnen, J., Brandjes, D., & Diamant, M. (2014). Intermittent fasting during Ramadan causes a transient increase in total, LDL, and HDL cholesterols and hs-CRP in ethnic obese adolescents. European Journal of Pediatrics, 173(8), 1103-6. https://doi.org/10.1007/s00431-014-2276-8
Lin, F., de Gooijer, M. C., Roig, E. M., Buil, L. C. M., Christner, S. M., Beumer, J. H., Würdinger, T., Beijnen, J. H., & van Tellingen, O. (2014). ABCB1, ABCG2, and PTEN determine the response of glioblastoma to temozolomide and ABT-888 therapy. Clinical Cancer Research, 20(10), 2703-2713. https://doi.org/10.1158/1078-0432.CCR-14-0084
van Hasselt, J. G. C., Allegaert, K., van Calsteren, K., Beijnen, J. H., Schellens, J. H. M., & Huitema, A. D. R. (2014). Semiphysiological versus empirical modelling of the population pharmacokinetics of free and total cefazolin during pregnancy. BioMed Research International, 2014, [897216]. https://doi.org/10.1155/2014/897216
ter Heine, R., Binkhorst, L., de Graan, A. J. M., de Bruijn, P., Beijnen, J. H., Mathijssen, R. H. J., & Huitema, A. D. R. (2014). Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen. British Journal of Clinical Pharmacology, 78(3), 572-586. https://doi.org/10.1111/bcp.12388
van Hasselt, J. G. C., van Calsteren, K., Heyns, L., Han, S., Mhallem Gziri, M., Schellens, J. H. M., Beijnen, J. H., Huitema, A. D. R., & Amant, F. (2014). Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel. Annals of Oncology, 25(10), 2059-2065. https://doi.org/10.1093/annonc/mdu140
Hendrikx, J. J. M. A., Lagas, J. S., Daling, R., Hooijberg, J. H., Schellens, J. H. M., Beijnen, J. H., Brandjes, D. P. M., & Huitema, A. D. R. (2014). Severe lactic acidosis in a diabetic patient after ethanol abuse and floor cleaner intake. Basic & Clinical Pharmacology & Toxicology, 115(5), 472-475. https://doi.org/10.1111/bcpt.12251
Mooiman, K. D., Goey, A. K. L., Huijbregts, T. J., Maas-Bakker, R. F., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2014). The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity. Journal of Pharmacy and Pharmacology, 66(9), 1339-46. https://doi.org/10.1111/jphp.12259
Lankheet, N. A. G., Kloth, J. S. L., Gadellaa-van Hooijdonk, C. G. M., Cirkel, G. A., Mathijssen, R. H. J., Lolkema, M. P. J. K., Schellens, J. H. M., Voest, E. E., Sleijfer, S., de Jonge, M. J. A., Haanen, J. B. A. G., Beijnen, J. H., Huitema, A. D. R., & Steeghs, N. (2014). Pharmacokinetically guided sunitinib dosing: a feasibility study in patients with advanced solid tumours. British Journal of Cancer, 110(10), 2441-2449. https://doi.org/10.1038/bjc.2014.194
Hendrikx, J. J. M. A., Lagas, J. S., Wagenaar, E., Rosing, H., Schellens, J. H. M., Beijnen, J. H., & Schinkel, A. H. (2014). Oral co-administration of elacridar and ritonavir enhances plasma levels of oral paclitaxel and docetaxel without affecting relative brain accumulation. British Journal of Cancer, 110(11), 2669-76. https://doi.org/10.1038/bjc.2014.222
van Hasselt, J. G. C., Schellens, J. H. M., Beijnen, J. H., & Huitema, A. D. R. (2014). Design of informative renal impairment studies: evaluation of the impact of design stratification on bias, precision and dose adjustment error. Investigational New Drugs, 32(5), 913-27. https://doi.org/10.1007/s10637-014-0103-8
Hendrikx, J. J. M. A., Rosing, H., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2014). Quantification of taxanes in biological matrices: a review of bioanalytical assays and recommendations for development of new assays. Bioanalysis, 6(7), 993-1010. https://doi.org/10.4155/bio.14.48
Jager, N. G. L., Rosing, H., Schellens, J. H. M., Beijnen, J. H., & Linn, S. C. (2014). Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen. Breast Cancer Research and Treatment, 146(1), 137-44. https://doi.org/10.1007/s10549-014-2999-2
Bardin, C., Veal, G., Paci, A., Chatelut, E., Astier, A., Levêque, D., Widmer, N., & Beijnen, J. (2014). Therapeutic drug monitoring in cancer--are we missing a trick? European Journal of Cancer, 50(12), 2005-9. https://doi.org/10.1016/j.ejca.2014.04.013
Paci, A., Veal, G., Bardin, C., Levêque, D., Widmer, N., Beijnen, J., Astier, A., & Chatelut, E. (2014). Review of therapeutic drug monitoring of anticancer drugs part 1--cytotoxics. European Journal of Cancer, 50(12), 2010-9. https://doi.org/10.1016/j.ejca.2014.04.014
Widmer, N., Bardin, C., Chatelut, E., Paci, A., Beijnen, J., Levêque, D., Veal, G., & Astier, A. (2014). Review of therapeutic drug monitoring of anticancer drugs part two--targeted therapies. European Journal of Cancer, 50(12), 2020-36. https://doi.org/10.1016/j.ejca.2014.04.015
Radhakishun, N., van Vliet, M., von Rosenstiel, I., Weijer, O., Diamant, M., Beijnen, J., & Brandjes, D. (2014). High prevalence of vitamin D insufficiency/deficiency in Dutch multi-ethnic obese children. European Journal of Pediatrics. https://doi.org/10.1007/s00431-014-2378-3
Radhakishun, N. N. E., van Vliet, M., Poland, D. C. W., Weijer, O., Beijnen, J. H., Brandjes, D. P. M., Diamant, M., & von Rosenstiel, I. A. (2014). Efficacy and tolerability of a high loading dose (25,000 IU weekly) vitamin D3 supplementation in obese children with vitamin D insufficiency/deficiency. Hormone research in pædiatrics, 82(2), 103-106. https://doi.org/10.1159/000362236
Marchetti, S., Pluim, D., Beijnen, J. H., Mazzanti, R., van Tellingen, O., & Schellens, J. H. M. (2014). "Effect of the drug transporters ABCB1, ABCC2, and ABCG2 on the disposition and brain accumulation of the taxane analog BMS-275,183". Investigational New Drugs, 32(6), 1083-1095. https://doi.org/10.1007/s10637-014-0143-0
Opdam, F. L., Huitema, A. D. R., Beijnen, J. H., & Schellens, J. H. M. (2014). Hyperglykemie bij gebruik van everolimus. Nederlands Tijdschrift voor Geneeskunde, 158, [A7544].
Gomez-Eerland, R., Nuijen, B., Heemskerk, B., van Rooij, N., van den Berg, J. H., Beijnen, J. H., Uckert, W., Kvistborg, P., Schumacher, T. N., Haanen, J. B. A. G., & Jorritsma, A. (2014). Manufacture of gene-modified human T-cells with a memory stem/central memory phenotype. Human gene therapy methods, 25(5), 277-287. https://doi.org/10.1089/hgtb.2014.004
Meulendijks, D., Dewit, L., Tomasoa, N. B., van Tinteren, H., Beijnen, J. H., Schellens, J. H. M., & Cats, A. (2014). Chemoradiotherapy with capecitabine for locally advanced anal carcinoma: an alternative treatment option. British Journal of Cancer, 111(9), 1726-33. https://doi.org/10.1038/bjc.2014.467
van Hasselt, J. G. C., van Eijkelenburg, N. K. A., Beijnen, J. H., Schellens, J. H. M., & Huitema, A. D. R. (2014). Design of a drug-drug interaction study of vincristine with azole antifungals in pediatric cancer patients using clinical trial simulation. Pediatric Blood & Cancer, 61(12), 2223-9. https://doi.org/10.1002/pbc.25198
Crombag, M-R. B. S., de Vries Schultink, A. H. M., Schellens, J. H. M., Beijnen, J. H., & Huitema, A. D. R. (2014). Incidence of hematologic toxicity in older adults treated with gemcitabine or a gemcitabine-containing regimen in routine clinical practice: a multicenter retrospective cohort study. Drugs & Aging, 31(10), 737-747. https://doi.org/10.1007/s40266-014-0207-z
Jager, N. G. L., Rosing, H., Schellens, J. H. M., & Beijnen, J. H. (2014). Procedures and practices for the validation of bioanalytical methods using dried blood spots: a review. Bioanalysis, 6(18), 2481-2514. https://doi.org/10.4155/bio.14.185
Yu, H., Steeghs, N., Kloth, J. S. L., de Wit, D., van Hasselt, J. G. C., van Erp, N. P., Beijnen, J. H., Schellens, J. H. M., Mathijssen, R. H. J., & Huitema, A. D. R. (Accepted/In press). Integrated semi-physiological pharmacokinetic model for both sunitinib and its active metabolite SU12662. British Journal of Clinical Pharmacology. https://doi.org/10.1111/bcp.12550
Jager, N. G., Rosing, H., Schellens, J. H., & Beijnen, J. H. (2014). Determination of tamoxifen and endoxifen in dried blood spots using LC-MS/MS and the effect of coated DBS cards on recovery and matrix effects. Bioanalysis, 6(22), 2999-3009. https://doi.org/10.4155/bio.14.157
Nijenhuis, C. M., Rosing, H., Schellens, J. H. M., & Beijnen, J. H. (2014). Quantifying vemurafenib in dried blood spots using high-performance LC-MS/MS. Bioanalysis, 6(23), 3215-3224. https://doi.org/10.4155/bio.14.171
Hendrikx, J. J. M. A., Beijnen, J. H., & Schinkel, A. H. (2014). P-gp and taxanes. Oncoscience, 1(7), 478-479. https://doi.org/10.18632/oncoscience.56
Lankheet, N. A. G., Schaake, E. E., Burgers, S. A., van Pel, R., Beijnen, J. H., Huitema, A. D. R., Klomp, H., & NEL study group (2014). Concentrations of Erlotinib in Tumor Tissue and Plasma in Non-Small-Cell Lung Cancer Patients After Neoadjuvant Therapy. Clinical Lung Cancer. https://doi.org/10.1016/j.cllc.2014.12.012
Dorlo, T. P. C., Rijal, S., Ostyn, B., de Vries, P. J., Singh, R., Bhattarai, N., Uranw, S., Dujardin, J-C., Boelaert, M., Beijnen, J. H., & Huitema, A. D. R. (2014). Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure. Journal of Infectious Diseases, 210(1), 146-153. https://doi.org/10.1093/infdis/jiu039
Houthuijzen, J. M., Daenen, L. G. M., Roodhart, J. M. L., Oosterom, I., van Jaarsveld, M. T. M., Govaert, K. M., Smith, M. E., Sadatmand, S. J., Rosing, H., Kruse, F., Helms, B. J., van Rooijen, N., Beijnen, J. H., Haribabu, B., van de Lest, C. H. A., & Voest, E. E. (2014). Lysophospholipids secreted by splenic macrophages induce chemotherapy resistance via interference with the DNA damage response. Nature Communications [E], 5, [5275]. https://doi.org/10.1038/ncomms6275
2013
Scholarly publications
Sparidans, R. W., Durmus, S., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2013). Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor dabrafenib in mouse plasma. Journal of chromatography. B, 925, 124-8. https://doi.org/10.1016/j.jchromb.2013.02.025
Mooiman, K. D., Maas-Bakker, R. F. M., Rosing, H., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2013). Development and validation of a LC-MS/MS method for the in vitro analysis of 1-hydroxymidazolam in human liver microsomes: application for determining CYP3A4 inhibition in complex matrix mixtures. Biomedical Chromatography, 27(9), 1107-16.
Jager, N. G. L., Koornstra, R. H. T., Vincent, A. D., van Schaik, R. H. N., Huitema, A. D. R., Korse, T. M., Schellens, J. H. M., Linn, S. C., & Beijnen, J. H. (2013). Hot flashes are not predictive for serum concentrations of tamoxifen and its metabolites. BMC Cancer, 13(1), 612. http://www.ncbi.nlm.nih.gov/pubmed/24373320
2012
Scholarly publications
Sparidans, R. W., Durmus, S., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2012). Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma. Journal of chromatography. B, 889-890, 144-147. https://doi.org/10.1016/j.jchromb.2012.02.010
Sparidans, R. W., Durmus, S., Xu, N., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2012). Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma. Journal of chromatography. B, 895-896, 174-177. https://doi.org/10.1016/j.jchromb.2012.03.021
Sparidans, R. W., Durmus, S., Xu, N., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2012). Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma. Journal of chromatography. B, 895-896, 169-173. https://doi.org/10.1016/j.jchromb.2012.03.020
Opstal-van Winden, A. W. J., Rodenburg, W., Pennings, J. L., van Oostrom, C. T., Beijnen, J. H., Peeters, P. H. M., van Gils, C. H., & de Vries, A. (2012). A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum. International Journal of Molecular Sciences, 13(10), 13587-13604. http://www.ncbi.nlm.nih.gov/pubmed/23202969
2011
Scholarly publications
Sparidans, R. W., Martens, I., Valkenburg-van Iersel, L. B. J., den Hartigh, J., Schellens, J. H. M., & Beijnen, J. H. (2011). Liquid chromatography-tandem mass spectrometric assay for the PARP-1 inhibitor olaparib in combination with the nitrogen mustard melphalan in human plasma. Journal of chromatography. B, 879(21), 1851-6. https://doi.org/10.1016/j.jchromb.2011.05.003
van den Hoven, JM., Van Tomme, S. R., Metselaar, J. M., Nuijen, B., Beijnen, J. H., & Storm, G. (2011). Liposomal drug formulations in the treatment of rheumatoid arthritis. Molecular Pharmaceutics, 8(4), 1002-05.
Teunissen, S. F., Jager, N. G., Rosing, H., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2011). Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry. Journal of chromatography. B, 879(19), 1677-85.
2010
Scholarly publications
Sparidans, R. W., van Velsen, S. G. A., de Roos, M. P., Schellens, J. H. M., Bruijnzeel-Koomen, C. A. F. M., & Beijnen, J. H. (2010). Liquid chromatography-tandem mass spectrometric assay for clobetasol propionate in human serum from patients with atopic dermatitis. Journal of chromatography. B, 878(23), 2150-2154. https://doi.org/10.1016/j.jchromb.2010.06.011
Sparidans, R. W., Iusuf, D., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2010). Liquid chromatography-tandem mass spectrometric assay for pravastatin and two isomeric metabolites in mouse plasma and tissue homogenates. Journal of chromatography. B, 878(28), 2751-9. https://doi.org/10.1016/j.jchromb.2010.08.015
2009
Scholarly publications
Sparidans, R. W., Vlaming, M. L. H., Lagas, J. S., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2009). Liquid chromatography-tandem mass spectrometric assay for sorafenib and sorafenib-glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite. Journal of chromatography. B, 877(3), 269-76. https://doi.org/10.1016/j.jchromb.2008.12.026
Sparidans, R. W., Iusuf, D., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2009). Liquid chromatography-tandem mass spectrometric assay for the light sensitive tyrosine kinase inhibitor axitinib in human plasma. Journal of chromatography. B, 877(32), 4090-4096. https://doi.org/10.1016/j.jchromb.2009.10.024
2008
Scholarly publications
Sparidans, R. W., Lagas, J. S., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2008). Liquid chromatography-tandem mass spectrometric assay for diclofenac and three primary metabolites in mouse plasma. Journal of chromatography. B, 872(1-2), 77-82. https://doi.org/10.1016/j.jchromb.2008.07.012
Harmsen, S., Koster, A. S., Beijnen, J. H., Schellens, J. H. M., & Meijerman, I. (2008). Comparison of two immortalized human cell lines to study nuclear receptor-mediated CYP3A4 induction. Drug Metabolism and Disposition, 36(6), 1166-1171. https://doi.org/10.1124/dmd.107.017335
Marchetti, S., de Vries, N. A., Buckle, T., Bolijn, M. J., van Eijndhoven, M. A. J., Beijnen, J. H., Mazzanti, R., van Tellingen, O., & Schellens, J. H. M. (2008). Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1(-/-)/Mdr1a/1b(-/-) (triple-knockout) and wild-type mice. Molecular Cancer Therapeutics, 7(8), 2280-2287.
2007
Scholarly publications
Sparidans, R. W., Prins, J. M., Schellens, J. H. M., & Beijnen, J. H. (2007). Liquid chromatography-tandem mass spectrometric assay for the nucleoside reverse transcriptase inhibitor emtricitabine in human plasma. Biomedical Chromatography, 21(6), 621-7. https://doi.org/10.1002/bmc.797
Sparidans, R. W., Lagas, J. S., Schinkel, A. H., Schellens, J. H. M., & Beijnen, J. H. (2007). Liquid chromatography-tandem mass spectrometric assays for salinomycin in mouse plasma, liver, brain and small intestinal contents and in OptiMEM cell culture medium. Journal of chromatography. B, 855(2), 200-10. https://doi.org/10.1016/j.jchromb.2007.05.008
van Herwaarden, A. E., Wagenaar, E., Van der Kruijssen, C. M. M., van Waterschoot, R. A., Smit, J. W., Song, J. Y., van der Valk, M. A., van Tellingen, O., van der Hoorn, J. W., Rosing, H., Beijnen, J. H., & Schinkel, A. H. (2007). Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. Journal of Clinical Investigation, 117, 3583-3592.
2006
Scholarly publications
Sparidans, R. W., Bosch, T. M., Jörger, M., Schellens, J. H. M., & Beijnen, J. H. (2006). Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes. Journal of chromatography. B, 839(1-2), 45-53. https://doi.org/10.1016/j.jchromb.2006.02.016
Sparidans, R. W., Dost, F., Crommentuyn, K. M. L., Huitema, A. D. R., Schellens, J. H. M., & Beijnen, J. H. (2006). Liquid chromatographic assay for the non-peptidic protease inhibitor tipranavir in plasma. Biomedical Chromatography, 20(8), 671-3. https://doi.org/10.1002/bmc.667
2005
Scholarly publications
Frankfort, S. V., Appels, B. A., de Boer, A., Tulner, L. R., van Campen, J. P. C. M., Koks, C. H. W., & Beijnen, J. H. (2005). Discontinuation of rivastigmine in routine clinical practice. International Journal of Geriatric Psychiatry, 20(12), 1167-71. https://doi.org/10.1002/gps.1411
2004
Scholarly publications
Sparidans, R. W., Schellens, J. H. M., López-Lázaro, L., Jimeno, J. M., & Beijnen, J. H. (2004). Liquid chromatographic assay for the cyclic depsipeptide aplidine, a new marine antitumor drug, in whole blood using derivatization with trans-4'-hydrazino-2-stilbazole. Biomedical Chromatography, 18(1), 16-20. https://doi.org/10.1002/bmc.286
Stokvis, E., Rosing, H., Lopez-Lazaro, L., & Beijnen, J. H. (2004). Simple and sensitive liquid chromatographic quantitative analysis of the novel marine anticancer drug Yondelis (ET-743, trabectedin) in human plasma using column switching and tandem mass spectrometric detection. Journal of Mass Spectrometry, 39, 431-436.
2002
Scholarly publications
Stokvis, E., Rosing, H., Lopez-Lazaro, L., Rodriguez, I., Jimeno, J. M., Supko, J. G., Schellens, J. H. M., & Beijnen, J. H. (2002). Quantitative analysis of the novel depsipeptide anticancer drug Kahalalide F in human plasma by high-performance liquid chromatorgaphy under basic conditions coupled to electrospray ionization tandem mass spectrometry. Journal of Mass Spectrometry, 37, 992-1000.
Professional publications
Lo Tam Loi, G. S., Beijnen, J. H., & Schellens, J. H. M. (2002). Problemen in de porte d'entree. Pharmaceutisch Weekblad, 137, 682-688.
2001
Scholarly publications
Nuijen, B., Bouma, M., Floriano, P., Manada, C., Rosing, H., Stokvis, E., Kettenes-van den Bosch, J. J., Bult, A., & Beijnen, J. H. (2001). Development of an HPLC method with UV detection for the pharmaceutical quality control of the novel marine anticancer agent Kahalalide F. Journal of Liquid Chromatography & Related Technology, 24(20), 3141-3155.
Huitema, A. D. R., Mathot, R. A. A., Tibben, M. M., Schellens, J. H. M., Rodenhuis, S., & Beijnen, J. H. (2001). Population pharmokinetics of thioTEPA and its active metabolite TEPA in patients undergoing high-dose chemotherapy. British Journal of Clinical Pharmacology, 51, 61-70.
Professional publications
Underberg, R. W. M., Crul, M., Beijnen, J. H., & Schellens, J. H. M. (2001). Farnesyltransferaseremmers: een nieuwe klasse oncolytica. Pharmaceutisch Weekblad, 136, 260-265.
Huitema, A. D. R., Tibben, M. M., Mathot, R. A. A., Schellens, J. H. M., Beijnen, J. H., & Rodenhuis, S. (2001). De relatie tussen toxiciteit en farmacokinetiek. Pharmaceutisch Weekblad, 45, 1721-1727.
2000
Scholarly publications
Malingré, M. M., Schellens, J. H. M., van Tellingen, O., Rosing, H., ten Bokkel Huinink, W. W., Swart, M., & Beijnen, J. H. (2000). Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after I.V. administration. Anti-Cancer Drugs, 11, 813-820.
Professional publications
den Brok, M. W. J., Haanen, J. B. A. G., & Beijnen, J. H. (2000). DNA-vaccins en kanker. Pharmaceutisch Weekblad, 135, 1748-1752.
1999
Scholarly publications
van Maanen, M. J., Tijhof, I. M., Damen, J. M. A., Versluis, C., Kettenes-van den Bosch, J. J., Heck, A. J. R., Rodenhuis, S., & Beijnen, J. H. (1999). A search for new metabolites of N,N',N"-triethylenethiophosphoramide. Cancer Research, 59, 4720-4724.
Professional publications
Veldkamp, A. I., Hoetelmans, R. M. W., & Beijnen, J. H. (1999). Ritonavir enables combined therapy with rifampin and saquinavir. Clinical Infectious Diseases, 29, 1586.
1998
Scholarly publications
van Maanen, R. J., van Ooijen, R. D., Zwikker, J. W., Huitema, A. D. R., Rodenhuis, S., & Beijnen, J. H. (1998). Determination of N,N',N''-triethylenthiophosphoramide and its active metabolite N,N',N''-triethylenphosphoramide in plasma and urine using capillary gas chromatography. Journal of chromatography. B, Biomedical sciences and applications, 719, 103-112.
Kaijser, G. P., & Beijnen, J. H. (1998). Clinical Pharmacology of Oxazaphosphorines: Cyclophosphamide and Ifosfamide. In L. B. Grochow, & M. M. Ames (Eds.), A Clinician's Guide to Chemotherapy Pharmacokinetics and Pharmacodynamics (pp. 229-258). Williams & Wilkins.