Prof. dr. Helga Gardarsdottir

Publications

2024

Scholarly publications

Møllebæk, M., Gardarsdottir, H., Bikou, A. G., Kodrič, A., Silva, A. M., Andersen, A., Kontogiorgis, C., Poplavska, E., Ahmadizar, F., Dermiki-Gkana, F., Rutkovska, I., Vaz, I. R., Kos, M., Barão, P., Grupstra, R., Alves, T. L., & Almarsdóttir, A. B. (2024). Challenges in the Implementation of EU Risk Minimisation Measures for Medicinal Products in Clinical Practice Guidelines: Mixed Methods Multi-Case Study. Drug Safety. Advance online publication. https://doi.org/10.1007/s40264-024-01487-5
Opalska, A., Gardarsdottir, H., Kwa, M., Wójkowska‑Mach, J., Sabate, M., Ballarin, M. E., de Groot, M., & Leufkens, H. (2024). Correction to: Use of antibiotics in the early COVID-19 pandemic in Poland, the Netherlands and Spain, from erraticism to (more) logic (European Journal of Clinical Pharmacology, (2024), 80, 10, (1581-1589), 10.1007/s00228-024-03726-1). European Journal of Clinical Pharmacology, 80(10), 1591. https://doi.org/10.1007/s00228-024-03742-1
https://research-portal.uu.nl/ws/files/240420652/s00228-024-03742-1.pdf
de Jong, A. J., Zuidgeest, M. G. P., Santa-Ana-Tellez, Y., de Boer, A., Gardarsdottir, H., & Trials@Home Consortium (2024). Regulatory readiness to facilitate the appropriate use of innovation in clinical trials: The case of decentralized clinical trial approaches. Drug Discovery Today, 29(11), Article 104180. https://doi.org/10.1016/j.drudis.2024.104180
https://research-portal.uu.nl/ws/files/241479105/1-s2.0-S1359644624003052-main.pdf
Hogervorst, M. A., Soman, K. V., Gardarsdottir, H., Goettsch, W. G., & Bloem, L. T. (2024). Analytical Methods for Comparing Uncontrolled Trials with External Controls from Real-World Data: a Systematic Literature Review and Comparison to European Regulatory and Health Technology Assessment Practice. Value in Health. Advance online publication. https://doi.org/10.1016/j.jval.2024.08.002
Grupstra, R. J., Goedecke, T., & Gardarsdottir, H. (2024). Limitations Reported in Evaluating Effectiveness of Risk Minimization Measures in the EU during 2018-2021: A Qualitative Analysis of Industry-Sponsored Post-Authorization Safety Studies. Clinical Pharmacology & Therapeutics, 116(5), 1252-1258. https://doi.org/10.1002/cpt.3369
https://research-portal.uu.nl/ws/files/242904209/Clin_Pharma_and_Therapeutics_-_2024_-_Grupstra_-_Limitations_Reported_in_Evaluating_Effectiveness_of_Risk_Minimization.pdf
Opalska, A., Gardarsdottir, H., Kwa, M., Wojkowska-Mach, J., Sabate, M., Ballarin, M. E., de Groot, M., & Leufkens, H. (2024). Use of antibiotics in the early COVID-19 pandemic in Poland, the Netherlands and Spain, from erraticism to (more) logic. European Journal of Clinical Pharmacology, 80(10), 1581–1589. https://doi.org/10.1007/s00228-024-03726-1
https://research-portal.uu.nl/ws/files/239624054/s00228-024-03726-1.pdf
Grupstra, R. J., Siiskonen, S. J., & Gardarsdottir, H. (2024). Risicominimalisatiemaatregelen voor geneesmiddelen. Nederlands Tijdschrift voor Geneeskunde, 168.
Gini, R., Pajouheshnia, R., Gardarsdottir, H., Bennett, D., Li, L., Gulea, C., Wientzek-Fleischmann, A., Bazelier, M. T., Burcu, M., Dodd, C., Durán, C. E., Kaplan, S., Lanes, S., Marinier, K., Roberto, G., Soman, K., Zhou, X., Platt, R., Setoguchi, S., & Hall, G. C. (2024). Describing diversity of real world data sources in pharmacoepidemiologic studies: The DIVERSE scoping review. Pharmacoepidemiology and Drug Safety, 33(5), Article e5787. https://doi.org/10.1002/pds.5787
https://dspace.library.uu.nl/bitstream/handle/1874/452281/Pharmacoepidemiology_and_Drug_-_2024_-_Gini_-_Describing_diversity_of_real_world_data_sources_in_pharmacoepidemiologic.pdf?sequence=1
Jansen, M. S., Dekkers, O. M., le Cessie, S., Hooft, L., Gardarsdottir, H., de Boer, A., & Groenwold, R. H. H. (2024). Real-World Evidence to Inform Regulatory Decision Making: A Scoping Review. Clinical Pharmacology and Therapeutics, 115(6), 1269-1276. https://doi.org/10.1002/cpt.3218
https://dspace.library.uu.nl/bitstream/handle/1874/452278/Clin_Pharma_and_Therapeutics_-_2024_-_Jansen_-_Real_World_Evidence_to_Inform_Regulatory_Decision_Making_A_Scoping_Review.pdf?sequence=1
Trials@Home Consortium, van Rijssel, T. I., van Thiel, G. J. M. W., Gardarsdottir, H., & van Delden, J. J. M. (2024). Which Benefits Can Justify Risks in Research? American Journal of Bioethics, 1-11. Advance online publication. https://doi.org/10.1080/15265161.2023.2296404
Trials@Home Consortium (2024). Opportunities and challenges for decentralized clinical trial approaches: European health technology assessment perspective. Value in Health, 27(3), 294-300. https://doi.org/10.1016/j.jval.2023.11.006
https://dspace.library.uu.nl/bitstream/handle/1874/437954/PIIS1098301523061971.pdf?sequence=1

2023

Scholarly publications

Grupstra, R. J., Goedecke, T., Scheffers, J., Strassmann, V., & Gardarsdottir, H. (2023). Review of Studies Evaluating Effectiveness of Risk Minimization Measures Assessed by the European Medicines Agency Between 2016 and 2021. Clinical Pharmacology and Therapeutics, 114(6), 1285-1292. https://doi.org/10.1002/cpt.3034
https://dspace.library.uu.nl/bitstream/handle/1874/434780/Clin_Pharma_and_Therapeutics_-_2023_-_Grupstra_-_Review_of_Studies_Evaluating_Effectiveness_of_Risk_Minimization_Measures.pdf?sequence=1
Meijboom, R. W., Gardarsdottir, H., Becker, M. L., Movig, K. L. L., Kuijvenhoven, J., Egberts, T. C. G., & Giezen, T. J. (2023). Discontinuation of infliximab treatment in patients with inflammatory bowel disease who retransitioned to originator and those who remained on biosimilar. Therapeutic Advances in Gastroenterology, 16, 1-15. https://doi.org/10.1177/17562848231197923
https://dspace.library.uu.nl/bitstream/handle/1874/437949/meijboom-et-al-2023-discontinuation-of-infliximab-treatment-in-patients-with-inflammatory-bowel-disease-who.pdf?sequence=1
Essink, S. C. M., Zomerdijk, I. M., Straus, S. M. J. M., Gardarsdottir, H., & De Bruin, M. L. (2023). Duration of Effectiveness Evaluation of Additional Risk Minimisation Measures for Centrally Authorised Medicinal Products in the EU Between 2012 and 2021. Drug Safety, 46(10), 1007-1020. https://doi.org/10.1007/s40264-023-01341-0
https://dspace.library.uu.nl/bitstream/handle/1874/434305/s40264-023-01341-0.pdf?sequence=1
Lasys, T., Santa-Ana-Tellez, Y., Siiskonen, S. J., Groenwold, R. H. H., & Gardarsdottir, H. (2023). Unintended impact of pharmacovigilance regulatory interventions: A systematic review. British Journal of Clinical Pharmacology, 89(12), 3491-3502. https://doi.org/10.1111/bcp.15874
https://dspace.library.uu.nl/bitstream/handle/1874/434300/Brit_J_Clinical_Pharma_-_2023_-_Lasys_-_Unintended_impact_of_pharmacovigilance_regulatory_interventions_A_systematic.pdf?sequence=1
Sindahl, P., Overgaard-Steensen, C., Wallach-Kildemoes, H., De Bruin, M. L., Kemp, K., & Gardarsdottir, H. (2023). Impact of a Treatment Guide on Intravenous Fluids in Minimising the Risk of Hospital-Acquired Hyponatraemia in Denmark. Journal of Clinical Medicine, 12(15), Article 5105. https://doi.org/10.3390/jcm12155105
https://dspace.library.uu.nl/bitstream/handle/1874/432830/jcm-12-05105-v2.pdf?sequence=1
Alsamil, A. M., Gardarsdottir, H., Leufkens, H. G., Egberts, T. C., & Giezen, T. J. (2023). Post-approval quality-related regulatory actions for biopharmaceuticals approved in the European Union and the United States between 1995 and 2019. Drug Discovery Today, 28(10), Article 103725. https://doi.org/10.1016/j.drudis.2023.103725
https://dspace.library.uu.nl/bitstream/handle/1874/432822/1-s2.0-S1359644623002416-main.pdf?sequence=1
Trials@Home Consortium (2023). Direct-to-Participant Investigational Medicinal Product Supply in Clinical Trials in Europe - Exploring the Experiences of Sponsors, Site Staff, and Couriers. British Journal of Clinical Pharmacology, 89(12), 3512-3522. https://doi.org/10.1111/bcp.15850
https://dspace.library.uu.nl/bitstream/handle/1874/434222/Brit_J_Clinical_Pharma_-_2023_-_Jong_-_Direct_to_participant_investigational_medicinal_product_supply_in_clinical_trials_in.pdf?sequence=1
Hempenius, M., Bots, S. H., Groenwold, R. H. H., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2023). Bias in observational studies on the effectiveness of in hospital use of hydroxychloroquine in COVID-19. Pharmacoepidemiology and Drug Safety, 32(9), 1001-1011. https://doi.org/10.1002/pds.5632
https://dspace.library.uu.nl/bitstream/handle/1874/432863/Pharmacoepidemiology_and_Drug_-_2023_-_Hempenius_-_Bias_in_observational_studies_on_the_effectiveness_of_in_hospital_use_of.pdf?sequence=1
Abtahi, S., Pajouheshnia, R., Durán, C. E., Riera-Arnau, J., Gamba, M., Alsina, E., Hoxhaj, V., Andersen, M., Bartolini, C., Kristiansen, S. B., Brown, J., Hallgreen, C. E., Garcia-Poza, P., Gardarsdottir, H., Gini, R., Girardi, A., Holthuis, E., Huerta, C., Ibánez, L., ... Klungel, O. (2023). Impact of 2018 EU Risk Minimisation Measures and Revised Pregnancy Prevention Programme on Utilisation and Prescribing Trends of Medicinal Products Containing Valproate: An Interrupted Time Series Study. Drug Safety, 46(7), 689-702. https://doi.org/10.1007/s40264-023-01314-3
https://dspace.library.uu.nl/bitstream/handle/1874/429522/s40264-023-01314-3.pdf?sequence=1
Eskola, S. M., Leufkens, H. G. M., Bate, A., De Bruin, M. L., & Gardarsdottir, H. (2023). The role of Real-World Data and evidence in oncology medicines approved in EU in 2018-2019. Journal of Cancer Policy, 36, Article 100424. https://doi.org/10.1016/j.jcpo.2023.100424
https://dspace.library.uu.nl/bitstream/handle/1874/428665/1_s2.0_S2213538323000413_main.pdf?sequence=1
Samukange, W. T., Lu, T.-A., Souverein, P. C., Gardarsdottir, H., & Mantel-Teeuwisse, A. K. (2023). Suspected adverse reactions reported for blood, blood components, and blood products in VigiBase. Transfusion, 63(5), 982-992. https://doi.org/10.1111/trf.17336
https://dspace.library.uu.nl/bitstream/handle/1874/428457/Transfusion_2023_Samukange_Suspected_adverse_reactions_reported_for_blood_blood_components_and_blood_products_in.pdf?sequence=1
Luijken, K., van Eekelen, R., Gardarsdottir, H., Groenwold, R. H. H., & van Geloven, N. (2023). Tell me what you want, what you really really want: Estimands in observational pharmacoepidemiologic comparative effectiveness and safety studies. Pharmacoepidemiology and Drug Safety, 32(8), 863-872. https://doi.org/10.1002/pds.5620
https://dspace.library.uu.nl/bitstream/handle/1874/429606/Pharmacoepidemiology_and_Drug_-_2023_-_Luijken_-_Tell_me_what_you_want_what_you_really_really_want_Estimands_in.pdf?sequence=1
Meijboom, R. W., Barbier, L., Druedahl, L. C., Sarnola, K., Tolonen, H. M., Gardarsdottir, H., Egberts, A., & Giezen, T. J. (2023). Recommendations on TNFα inhibitor biosimilar use in clinical practice: a comparison of European gastroenterology IBD guidance. Expert Opinion on Biological Therapy, 23(8), 801-817. https://doi.org/10.1080/14712598.2023.2189008
https://dspace.library.uu.nl/bitstream/handle/1874/431415/Recommendations_on_TNF_inhibitor_biosimilar_use_in_clinical_practice_a_comparison_of_European_gastroenterology_IBD_guidance.pdf?sequence=1
Hunt, N. B., Pajouheshnia, R., Salih, A., van Doorn, S., Souverein, P. C., Bazelier, M. T., Klungel, O. H., & Gardarsdottir, H. (2023). Prescribing of low-dose rivaroxaban in patients with atherosclerotic cardiovascular disease in the United Kingdom and the Netherlands. British Journal of Clinical Pharmacology, 89(7), 2263-2271. https://doi.org/10.1111/bcp.15708
https://dspace.library.uu.nl/bitstream/handle/1874/429486/Brit_J_Clinical_Pharma_-_2023_-_Hunt_-_Prescribing_of_low_dose_rivaroxaban_in_patients_with_atherosclerotic_cardiovascular.pdf?sequence=1
Trials@Home Consortium (2023). Decentralised, patient-centric, site-less, virtual, and digital clinical trials? From confusion to consensus. Drug Discovery Today, 28(4), Article 103520. https://doi.org/10.1016/j.drudis.2023.103520
https://dspace.library.uu.nl/bitstream/handle/1874/428446/1_s2.0_S1359644623000363_main.pdf?sequence=1
Hempenius, M., Rijken, S., Groenwold, R. H. H., Hek, K., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2023). Primary nonadherence to drugs prescribed by general practitioners: A Dutch database study. British Journal of Clinical Pharmacology, 89(1), 268-278. https://doi.org/10.1111/bcp.15472
https://dspace.library.uu.nl/bitstream/handle/1874/425630/Brit_J_Clinical_Pharma_2022_Hempenius_Primary_nonadherence_to_drugs_prescribed_by_general_practitioners_A_Dutch.pdf?sequence=1
Melis, E. J., Zwart-van Rijkom, J. E., Egberts, T. C., van den Bemt, B. J., Witteveen, P. O., & Gardarsdottir, H. (2023). The association between patient satisfaction with information and adherence to oral anticancer agents. Journal of Oncology Pharmacy Practice, 29(3), 637–645. https://doi.org/10.1177/10781552221077258
https://dspace.library.uu.nl/bitstream/handle/1874/428381/10781552221077258.pdf?sequence=1

Other output

Eskola, S. M., Jokinen, S., Bloem, L. T., Brouwer, E., Brown, D. A., Camarero, J., De Bruin, M. L. L., Gardarsdottir, H., & Hakkarainen, K. M. (2023). Systematic review of externally controlled (EC) trials, data used in them, and their role in regulatory decision-making. Pharmacoepidemiology and Drug Safety, 32(supplement 1), 260-261. Article 260.

2022

Scholarly publications

Lasys, T., Santa-Ana-Tellez, Y., Siiskonen, S., Groenwold, R. H. H., & Gardarsdottir, H. (2022). Unintended impact of medicines regulatory interventions: A systematic review focusing on data and methods. Pharmacoepidemiology and Drug Safety, 31, 223-224.
Trials@Home Consortium (2022). A cross-sectional survey on the early impact of COVID-19 on the uptake of decentralised trial methods in the conduct of clinical trials. Trials, 23(1), 1-12. Article 856. https://doi.org/10.1186/s13063-022-06706-x
https://dspace.library.uu.nl/bitstream/handle/1874/424168/s13063_022_06706_x.pdf?sequence=1
Trials@Home Consortium (2022). Which decentralised trial activities are reported in clinical trial protocols of drug trials initiated in 2019-2020? A cross-sectional study in ClinicalTrials.gov. BMJ Open, 12(8). https://doi.org/10.1136/bmjopen-2022-063236
https://dspace.library.uu.nl/bitstream/handle/1874/424675/e063236.full.pdf?sequence=1
Alsamil, A. M., Giezen, T. J., Egberts, T. C., Doevendans, E., Leufkens, H. G., & Gardarsdottir, H. (2022). Nature and timing of post-approval manufacturing changes of tumour necrosis factor α inhibitor products: A 20-year follow-up study of originators and biosimilars. European Journal of Pharmaceutical Sciences, 175, 1-8. Article 106227. https://doi.org/10.1016/j.ejps.2022.106227
https://dspace.library.uu.nl/bitstream/handle/1874/422245/1_s2.0_S0928098722001129_main.pdf?sequence=1
Trials@Home Consortium (2022). Opportunities and Challenges for Decentralized Clinical Trials: European Regulators' Perspective. Clinical Pharmacology and Therapeutics, 112(2), 344-352. https://doi.org/10.1002/cpt.2628
https://dspace.library.uu.nl/bitstream/handle/1874/422281/Clin_Pharma_and_Therapeutics_2022_Jong_Opportunities_and_Challenges_for_Decentralized_Clinical_Trials_European.pdf?sequence=1
Camacho-Arteaga, L. F., Gardarsdottir, H., Ibañez, L., Souverein, P. C., van Dijk, L., Hek, K., Vidal, X., Ballarín, E., & Sabaté, M. (2022). Indications related to antidepressant prescribing in the Nivel-PCD database and the SIDIAP database. Journal of Affective Disorders, 303, 131-137. https://doi.org/10.1016/j.jad.2022.02.001
https://dspace.library.uu.nl/bitstream/handle/1874/422268/1_s2.0_S0165032722001392_main.pdf?sequence=1
Meijboom, R. W., Gardarsdottir, H., Egberts, T. C. G., & Giezen, T. J. (2022). Patients Retransitioning from Biosimilar TNFα Inhibitor to the Corresponding Originator After Initial Transitioning to the Biosimilar: A Systematic Review. BioDrugs, 36(1), 27-39. https://doi.org/10.1007/s40259-021-00508-4
https://dspace.library.uu.nl/bitstream/handle/1874/421315/Meijboom2022_Article_PatientsRetransitioningFromBio.pdf?sequence=1
Eskola, S. M., Leufkens, H. G. M., Bate, A., De Bruin, M. L., & Gardarsdottir, H. (2022). Use of Real World Data and Evidence in Drug Development of Medicinal Products Centrally Authorized in Europe in 2018-2019. Clinical Pharmacology and Therapeutics, 111(1), 310-320. https://doi.org/10.1002/cpt.2462
https://dspace.library.uu.nl/bitstream/handle/1874/428423/Clin_Pharma_and_Therapeutics_2021_Eskola_Use_of_Real_World_Data_and_Evidence_in_Drug_Development_of_Medicinal.pdf?sequence=1
Sindahl, P., Ofori-Asenso, R., Hallgreen, C. E., Kemp, K., Gardarsdottir, H., & De Bruin, M. L. (2022). Impact of regulatory interventions to restrict the combined use of renin–angiotensin system blockers: A Danish nationwide drug utilisation study. British Journal of Clinical Pharmacology, 88(3), 1379-1384. https://doi.org/10.1111/bcp.15080
https://dspace.library.uu.nl/bitstream/handle/1874/425137/Brit_J_Clinical_Pharma_2021_Sindahl_Impact_of_regulatory_interventions_to_restrict_the_combined_use_of_renin.pdf?sequence=1
Wang, T., McAuslane, N., Gardarsdottir, H., Goettsch, W. G., & Leufkens, H. G. M. (2022). Building HTA insights into the drug development plan: Current approaches to seeking early scientific advice from HTA agencies. Drug Discovery Today, 27(1), 347-353. https://doi.org/10.1016/j.drudis.2021.09.014
https://dspace.library.uu.nl/bitstream/handle/1874/416184/1_s2.0_S1359644621004086_main.pdf?sequence=1

2021

Scholarly publications

Sabaté, M., Vidal, X., Ballarin, E., Rottenkolber, M., Schmiedl, S., Grave, B., Huerta, C., Martin-Merino, E., Montero, D., Leon-Muñoz, L. M., Gasse, C., Moore, N., Droz, C., Lassalle, R., Aakjær, M., Andersen, M., De Bruin, M. L., Souverein, P., Klungel, O. H., ... Ibáñez, L. (2021). Adherence to Direct Oral Anticoagulants in Patients With Non-Valvular Atrial Fibrillation: A Cross-National Comparison in Six European Countries (2008-2015). Frontiers in Pharmacology, 12, Article 682890. https://doi.org/10.3389/fphar.2021.682890
https://dspace.library.uu.nl/bitstream/handle/1874/413709/fphar_12_682890.pdf?sequence=1
Samukange, W. T., Kluempers, V., Porwal, M., Mudyiwenyama, L., Mutoti, K., Aineplan, N., Gardarsdottir, H., Mantel-Teeuwisse, A. K., & Nuebling, C. M. (2021). Implementation and performance of haemovigilance systems in 10 sub-saharan African countries is sub-optimal. BMC Health Services Research, 21(1), 1-12. Article 1258. https://doi.org/10.1186/s12913-021-07235-0
https://dspace.library.uu.nl/bitstream/handle/1874/413708/s12913_021_07235_0.pdf?sequence=1
Meijboom, R. W., Gardarsdottir, H., Becker, M. L., ten Wolde, S., Egberts, T. C. G., & Giezen, T. J. (2021). Incidence of and Reasons and Determinants Associated with Retransitioning from Biosimilar Etanercept to Originator Etanercept. BioDrugs, 35(6), 765–772. https://doi.org/10.1007/s40259-021-00501-x
https://dspace.library.uu.nl/bitstream/handle/1874/413406/Meijboom2021_Article_IncidenceOfAndReasonsAndDeterm.pdf?sequence=1
Meijboom, R. W., Gardarsdottir, H., Becker, M. L., de Groot, M. C. H., Movig, K. L. L., Kuijvenhoven, J., Egberts, T. C. G., Leufkens, H. G. M., & Giezen, T. J. (2021). Switching TNFα inhibitors: Patterns and determinants. Pharmacology Research and Perspectives, 9(4), 1-9. Article e00843. https://doi.org/10.1002/prp2.843
https://dspace.library.uu.nl/bitstream/handle/1874/412868/Pharmacology_Res_Perspec_2021_Meijboom_Switching_TNF_inhibitors_Patterns_and_determinants.pdf?sequence=1
van den Ham, H. A., Souverein, P. C., Klungel, O. H., Platt, R. W., Ernst, P., Dell'Aniello, S., Schmiedl, S., Grave, B., Rottenkolber, M., Huerta, C., Martín Merino, E., León-Muñoz, L. M., Montero, D., Andersen, M., Aakjær, M., De Bruin, M. L., & Gardarsdottir, H. (2021). Major bleeding in users of direct oral anticoagulants in atrial fibrillation: A pooled analysis of results from multiple population-based cohort studies. Pharmacoepidemiology and Drug Safety, 30(10), 1339-1352. https://doi.org/10.1002/pds.5317
https://dspace.library.uu.nl/bitstream/handle/1874/418897/Pharmacoepidemiology_and_Drug_2021_Ham_Major_bleeding_in_users_of_direct_oral_anticoagulants_in_atrial_fibrillation_.pdf?sequence=1
Hempenius, M., Groenwold, R. H. H., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2021). Drug exposure misclassification in pharmacoepidemiology: sources and relative impact. Pharmacoepidemiology and Drug Safety, 30(12), 1703-1715. https://doi.org/10.1002/pds.5346
https://dspace.library.uu.nl/bitstream/handle/1874/418896/Pharmacoepidemiology_and_Drug_2021_Hempenius_Drug_exposure_misclassification_in_pharmacoepidemiology_Sources_and.pdf?sequence=1
Abdullah-Koolmees, H., Nawzad, S., Egberts, T. C. G., Vuyk, J., Gardarsdottir, H., & Heerdink, E. R. (2021). The effect of non-adherence to antipsychotic treatment on rehospitalization in patients with psychotic disorders. Therapeutic Advances in Psychopharmacology, 11, 1-12. https://doi.org/10.1177/20451253211027449
https://dspace.library.uu.nl/bitstream/handle/1874/412838/10.1177_20451253211027449.pdf?sequence=1
Zhang, Y., Souverein, P. C., & Gardarsdottir, H. (2021). DOAC drug interactions and risk of major bleeding. Drug and Therapeutics Bulletin, 59(5), 70. https://doi.org/10.1136/dtb.2021.000014
https://dspace.library.uu.nl/bitstream/handle/1874/428448/70.full.pdf?sequence=1
Sindahl, P., Overgaard-Steensen, C., Wallach-Kildemoes, H., De Bruin, M. L., Kjær, M. B. N., Kemp, K., & Gardarsdottir, H. (2021). A cross-sectional survey of knowledge pertaining to IV fluid therapy and hyponatraemia among nurses working at emergency departments in Denmark. International Emergency Nursing, 57, 1-8. Article 101010. https://doi.org/10.1016/j.ienj.2021.101010
https://dspace.library.uu.nl/bitstream/handle/1874/412574/1_s2.0_S1755599X21000483_main.pdf?sequence=1
Luijken, K., Spekreijse, J. J., van Smeden, M., Gardarsdottir, H., & Groenwold, R. H. H. (2021). New-user and prevalent-user designs and the definition of study time origin in pharmacoepidemiology: a review of reporting practices. Pharmacoepidemiology and Drug Safety, 30(7), 960-974. https://doi.org/10.1002/pds.5258
https://dspace.library.uu.nl/bitstream/handle/1874/412095/pds.5258.pdf?sequence=1
Hunt, N. B., Gardarsdottir, H., Bazelier, M. T., Klungel, O. H., & Pajouheshnia, R. (2021). A Systematic Review of How Missing Data are Handled and Reported in Multi-Database Pharmacoepidemiologic studies. Pharmacoepidemiology and Drug Safety, 30(7), 819-826. https://doi.org/10.1002/pds.5245
https://dspace.library.uu.nl/bitstream/handle/1874/411880/pds.5245.pdf?sequence=1
van Hunsel, F., Peters, L., Gardarsdottir, H., & Kant, A. (2021). Assessing the Impact on Health of Pharmacovigilance Activities: Example of Four Safety Signals. Drug Safety, 44, 589-600. https://doi.org/10.1007/s40264-021-01047-1
https://dspace.library.uu.nl/bitstream/handle/1874/411694/Hunsel2021_Article_AssessingTheImpactOnHealthOfPh.pdf?sequence=1
Hempenius, M., Groenwold, R. H. H., Souverein, P. C., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2021). Impact of anticoagulant exposure misclassification on the bleeding risk of direct oral anticoagulants. British Journal of Clinical Pharmacology, 87(9), 3508-3517. https://doi.org/10.1111/bcp.14764
https://dspace.library.uu.nl/bitstream/handle/1874/411693/bcp.14764.pdf?sequence=1
Alsamil, A. M., Giezen, T. J., Egberts, T. C., Leufkens, H. G., & Gardarsdottir, H. (2021). Comparison of consistency and complementarity of reporting biosimilar quality attributes between regulatory and scientific communities: An adalimumab case study. Biologicals, 69, 30-37. https://doi.org/10.1016/j.biologicals.2020.12.003
https://dspace.library.uu.nl/bitstream/handle/1874/411692/1_s2.0_S1045105620301421_main.pdf?sequence=1
Trials@Home Consortium (2021). COVID-19 and the Emerging Regulatory Guidance for Ongoing Clinical Trials in the European Union. Clinical Pharmacology and Therapeutics, 109(6), 1517-1527. https://doi.org/10.1002/cpt.2225
https://research-portal.uu.nl/ws/files/97432334/cpt.2225.pdf
Alsamil, A. M., Giezen, T. J., Egberts, T. C., Leufkens, H. G., & Gardarsdottir, H. (2021). Type and Extent of Information on (Potentially Critical) Quality Attributes Described in European Public Assessment Reports for Adalimumab Biosimilars. Pharmaceuticals (Basel, Switzerland), 14(3), 1-14. Article 189. https://doi.org/10.3390/ph14030189
https://dspace.library.uu.nl/bitstream/handle/1874/411691/pharmaceuticals_14_00189_v2.pdf?sequence=1
Minnema, L. A., Giezen, T. J., Hoekman, J., Egberts, T. C. G., Leufkens, H. G. M., & Gardarsdottir, H. (2021). Regulatory safety learning driven by the mechanism of action: the case of TNF-α inhibitors. Clinical Pharmacology and Therapeutics, 110(1), 123-131. https://doi.org/10.1002/cpt.2127
https://dspace.library.uu.nl/bitstream/handle/1874/410014/cpt.2127.pdf?sequence=1
PE, PV consortium H. Gardarsdottir (2021). Prescribers' compliance with Summary of Product Characteristics of dabigatran, rivaroxaban and apixaban - a European comparative drug utilization study. Basic & Clinical Pharmacology & Toxicology, 128(3), 440-454. https://doi.org/10.1111/bcpt.13517
https://dspace.library.uu.nl/bitstream/handle/1874/428439/Basic_Clin_Pharma_Tox_2020_Rottenkolber_Prescribers_compliance_with_summary_of_product_characteristics_of_dabigatran.pdf?sequence=1
Souverein, P. C., van den Ham, H. A., Huerta, C., Merino, E. M., Montero, D., León-Muñoz, L. M., Schmiedl, S., Heeke, A., Rottenkolber, M., Andersen, M., Aakjaer, M., De Bruin, M. L., Klungel, O. H., & Gardarsdottir, H. (2021). Comparing risk of major bleeding between users of different oral anticoagulants in patients with nonvalvular atrial fibrillation. British Journal of Clinical Pharmacology, 87(3), 988-1000. https://doi.org/10.1111/bcp.14450
https://dspace.library.uu.nl/bitstream/handle/1874/428424/Brit_J_Clinical_Pharma_2020_Souverein_Comparing_risk_of_major_bleeding_between_users_of_different_oral_anticoagulants.pdf?sequence=1

Professional publications

Gardarsdottir, H., Goedecke, T., Pacurariu, A., & Morales, D. (2021). ENCePP Guide on Methodological Standards in Pharmacoepidemiology: 14.4. Methods for pharmacovigilance impact research. In ENCePP Guide on Methodological Standards in Pharmacoepidemiology: 14.4. Methods for pharmacovigilance impact research (pp. 99-108)
Koster, E., Philbert, D., & Gardarsdottir, H. (2021). Implementatie keuzetool zelfzorgapps blijkt lastig: Diabetes: Gebruik van apps bij ondersteuning van zelfmanagement. Pharmaceutisch Weekblad, 156(35), 14-15.

2020

Scholarly publications

Wang, T., McAuslane, N., Liberti, L., Gardarsdottir, H., Goettsch, W., & Leufkens, H. (2020). Companies' Health Technology Assessment Strategies and Practices in Australia, Canada, England, France, Germany, Italy and Spain: An Industry Metrics Study. Frontiers in Pharmacology, 11, Article 594549. https://doi.org/10.3389/fphar.2020.594549
https://dspace.library.uu.nl/bitstream/handle/1874/410887/fphar_11_594549.pdf?sequence=1
Opalska, A., Kwa, M., Leufkens, H., & Gardarsdottir, H. (2020). Enabling appropriate use of antibiotics: review of European Union procedures of harmonising product information, 2007 to 2020. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 25(45), 1-7. https://doi.org/10.2807/1560-7917.ES.2020.25.45.2000035
https://dspace.library.uu.nl/bitstream/handle/1874/410015/eurosurv_25_45_5.pdf?sequence=1
Coppens, D. G., Gardarsdottir, H., Bruin, M. L. D., Meij, P., Gm Leufkens, H., & Hoekman, J. (2020). Regulating advanced therapy medicinal products through the Hospital Exemption: an analysis of regulatory approaches in nine EU countries. Regenerative Medicine, 15(8), 2015-2028. https://doi.org/10.2217/rme-2020-0008
https://dspace.library.uu.nl/bitstream/handle/1874/428437/rme_2020_0008.pdf?sequence=1
Alsamil, A. M., Giezen, T. J., Egberts, T. C., Leufkens, H. G., Vulto, A. G., van der Plas, M. R., & Gardarsdottir, H. (2020). Reporting of quality attributes in scientific publications presenting biosimilarity assessments of (intended) biosimilars: a systematic literature review. European Journal of Pharmaceutical Sciences, 154, Article 105501. https://doi.org/10.1016/j.ejps.2020.105501
https://dspace.library.uu.nl/bitstream/handle/1874/408911/1_s2.0_S0928098720302906_main.pdf?sequence=1
Sindahl, P., Overgaard-Steensen, C., Wallach-Kildemoes, H., De Bruin, M. L., Leufkens, H. G., Kemp, K., & Gardarsdottir, H. (2020). Are further interventions needed to prevent and manage hospital-acquired hyponatraemia? A nationwide cross-sectional survey of IV fluid prescribing practices. Journal of Clinical Medicine, 9(9), 1-16. Article 2790. https://doi.org/10.3390/jcm9092790
https://dspace.library.uu.nl/bitstream/handle/1874/408910/jcm_09_02790_v2.pdf?sequence=1
Minnema, L. A., Giezen, T. J., Egberts, T. C. G., Leufkens, H. G. M., & Gardarsdottir, H. (2020). Adverse events related to biologicals used for patients with multiple sclerosis: a comparison between information originating from regulators and information originating from the scientific community. European Journal of Neurology, 27(7), 1250-1256. https://doi.org/10.1111/ene.14259
https://dspace.library.uu.nl/bitstream/handle/1874/408371/ene.14259.pdf?sequence=1
Coppens, D. G. M., Hoekman, J., De Bruin, M. L., Slaper-Cortenbach, I. C. M., Leufkens, H. G. M., Meij, P., & Gardarsdottir, H. (2020). Advanced therapy medicinal product manufacturing under the hospital exemption and other exemption pathways in seven European Union countries. Cytotherapy, 22(10), 592-600. https://doi.org/10.1016/j.jcyt.2020.04.092
https://dspace.library.uu.nl/bitstream/handle/1874/408366/1_s2.0_S1465324920306320_main.pdf?sequence=1
Hempenius, M., Luijken, K., de Boer, A., Klungel, O., Groenwold, R., & Gardarsdottir, H. (2020). Quality of reporting of drug exposure in pharmacoepidemiological studies. Pharmacoepidemiology and Drug Safety, 29(9), 1141-1150. https://doi.org/10.1002/pds.5020
https://dspace.library.uu.nl/bitstream/handle/1874/428123/Pharmacoepidemiology_and_Drug_2020_Hempenius_Quality_of_reporting_of_drug_exposure_in_pharmacoepidemiological_studies.pdf?sequence=1
Coppens, D. G., Gardarsdottir, H., van den Bogert, C. A., De Bruin, M. L., Leufkens, H. G., & Hoekman, J. (2020). Publication rates and reported results in a cohort of gene- and cell-based therapy trials. Regenerative Medicine, 15(1), 1215-1227. https://doi.org/10.2217/rme-2019-0066
https://dspace.library.uu.nl/bitstream/handle/1874/408024/rme_2019_0066.pdf?sequence=1
Zhang, Y., Souverein, P. C., Gardarsdottir, H., van den Ham, H. A., Maitland-van der Zee, A. H., & de Boer, A. (2020). Risk of major bleeding among users of direct oral anticoagulants combined with interacting drugs: a population-based nested case-control study. British Journal of Clinical Pharmacology, 86(6), 1150-1164. https://doi.org/10.1111/bcp.14227
https://dspace.library.uu.nl/bitstream/handle/1874/407972/bcp.14227.pdf?sequence=1
Samukange, W. T., Gardarsdottir, H., Leufkens, H. G. M., & Mantel-Teeuwise, A. K. (2020). Selection of Blood, Blood Components, and Blood Products as Essential Medicines in 105 Low- and Middle-Income Countries. Transfusion Medicine Reviews, 34(2), 94-100. https://doi.org/10.1016/j.tmrv.2019.10.005
https://dspace.library.uu.nl/bitstream/handle/1874/407832/1_s2.0_S0887796319301476_main.pdf?sequence=1

Professional publications

Bekker, C. L., van den Bemt, B. J. F., Gardarsdottir, H., Egberts, A. C. G., & Bouvy, M. L. (2020). Geneesmiddelverspilling verminderen. Nederlands Tijdschrift voor Geneeskunde, 164.
https://dspace.library.uu.nl/bitstream/handle/1874/428095/d4812.pdf?sequence=1

2019

Scholarly publications

van den Ham, H., Souverein, P., Klungel, O., Platt, R., Ernst, P., Dell'Aniello, S., Schmiedl, S., Grave, B., Rottenkolber, M., Huerta, C., Merino, E. M., Leon-Munoz, L., Montero, D., Andersen, M., Aakjaer, M., Bruin, M. L. D., & Gardarsdottir, H. (2019). Risk of major bleeding associated with the use of individual direct oral anticoagulants compared to vitamin K antagonists in patients with non-valvular atrial fibrillation: A metaanalysis of results from multiple population based cohort studies using a common protocol in Europe and Canada. Pharmacoepidemiology and Drug Safety, 28(S2). https://doi.org/10.1002/pds.4864
Souverein, P. C., Van Den Ham, H. A., Huerta, C., Merino, E. M., Montero, D., León-Muñoz, L. M., Schmiedl, S., Rottenkolber, M., Andersen, M., Aakjær, M., De Bruin, M. L., Klungel, O. H., & Gardarsdottir, H. (2019). Risk of major bleeding associated with the use of direct oral anticoagulants compared to vitamin K antagonists in patients with atrial fibrillation: A European multicountry population-based cohort study. Pharmacoepidemiology and Drug Safety, 28(S2), 553-553. https://doi.org/10.1002/pds.4864
Pajouheshnia, R., Gardarsdottir, H., Platt, R., Toh, D., & Klungel, O. (2019). Analysis of data from distributed pharmacoepidemiologic networks. Pharmacoepidemiology and Drug Safety, 28(S2), 414. https://doi.org/10.1002/pds.4864
Bekker, C., Van Den Bemt, B. J., Egberts, A. C., Bouvy, M. L., & Gardarsdottir, H. (2019). Willingness of patients to use unused medications returned to the pharmacy by another patient. International Journal of Clinical Pharmacy, 41(1), 302-303. https://doi.org/10.1007/s11096-018-0759-9
Van Den Ham, H., Souverein, P., Klungel, O., Platt, R., Ernst, P., Dell'Aniello, S., Schmiedl, S., Grave, B., Rottenkolber, M., Huerta, C., Merino, E. M., León-Muñoz, L., Montero, D., Andersen, M., Aakjær, M., De Bruin, M., & Gardarsdottir, H. (2019). Risk of major bleeding associated with the use of individual direct oral anticoagulants compared to vitamin K antagonists in patients with non-valvular atrial fibrillation: A metaanalysis of results from multiple population based cohort studies using a common protocol in Europe and Canada. Pharmacoepidemiology and Drug Safety, 28(S2), 410-411. https://doi.org/10.1002/pds.4864
Rottenkolber, M., Schmiedl, S., Ibanez, L., Sabaté, M., Ballarín, E., Vidal, X., Leon-Munoz, L. M., Huerta, C., Martin Merino, E., Montero, D., Gasse, C., Andersen, M., Aakjær, M., De Bruin, M. L., Gerlach, R., Tauscher, M., Souverein, P. C., Van Den Ham, R., Klungel, O., & Gardarsdottir, H. (2019). Prescribers' compliance with SmPC recommendations for dabigatran, rivaroxaban, and Apixaban: A European comparative drug utilization study. Pharmacoepidemiology and Drug Safety, 28(S2), 148-149. https://doi.org/10.1002/pds.4864
Meijboom, R. W., Gardarsdottir, H., Becker, M. L., Egberts, T. C. G., Leufkens, H. G. M., & Giezen, T. J. (2019). TNF-alpha inhibitor treatment patterns in patients with rheumatic diseases and those with inflammatory bowel disease. Pharmacoepidemiology and Drug Safety, 28(S2), 265-265. https://doi.org/10.1002/pds.4864
Ibanez, L., Sabaté, M., Vidal, X., Ballarín, E., Rottenkolber, M., Schmiedl, S., Heeke, A., Huerta, C., Merino, E. M., Montero, D., Leon-Muñoz, L. M., Gasse, C., Moore, N., Droz, C., Lassalle, R., Aakjaer, M., Andersen, M., De Bruin, M. L., Groenwold, R., ... Gardarsdottir, H. (2019). Incidence of direct oral anticoagulation use for non valvular atrial fibrillation and characteristics of users in six European countries (2008-2015): A cross-national drug utilization study. Pharmacoepidemiology and Drug Safety, 28(S2), 397. https://doi.org/10.1002/pds.4864
Sabaté Gallego, M., Ibáñez Mora, L., Vidal Guitart, X., Ballarin Alins, E., Rottenkolber, M., Schmiedl, S., Heeke, A., Huerta, C., Martin Merino, E., Montero, D., León-Muñoz, L. M., Gasse, C., Moore, N., Droz, C., Lassalle, R., Aakjaer, M., Andersen, M., De Briun, M., Groenwold, R., ... Gardarsdottir, H. (2019). Adherence to direct oral anticoagulants in patients with non-valvular atrial fibrillation cross-national comparison in six european countries. European Journal of Clinical Pharmacology, 75, 27-28. https://doi.org/10.1007/s00228-019-02685-2
Hempenius, M., Luijken, K., De Boer, A., Klungel, O. H., Groenwold, R. H. H., & Gardarsdottir, H. (2019). Current practice in reporting exposure in pharmacoepidemiological studies. 428. Abstract from 35th International conference on Pharmacoepidemiology & therapeutic risk management., Philapdelphia, Pennsylvania, United States. https://doi.org/10.1002/pds.4864
Vlieland, N. D., van den Bemt, B. J. F., Wouters, H., Egberts, A. C. G., Bouvy, M., & Gardarsdottir, H. (2019). Associations between personality traits and adequate home storage of drugs in older patients. Psychology, Health and Medicine, 24(10), 1255-1266. https://doi.org/10.1080/13548506.2019.1634822
https://dspace.library.uu.nl/bitstream/handle/1874/386488/Associations_between_personality_traits_and_adequate_home_storage_of_drugs_in_older_patients.pdf?sequence=1
Camacho Arteaga, L. F., Gardarsdottir, H., Souverein, P., Van Dijk, L., Sabaté, M., Vidal, X., Ballarín, E., & Ibañez, L. (2019). Indications related to antidepressant drug prescribing in the elderly population during 2010-2015 in two primary care databases: the Netherlands and Catalonia (Spain). European Journal of Clinical Pharmacology, 75(suppl 1), 49-50. https://doi.org/10.1007/s00228-019-02685-2
Ibáñez, L., Sabaté, M., Vidal, X., Ballarin, E., Rottenkolber, M., Schmiedl, S., Heeke, A., Huerta, C., Martin Merino, E., Montero, D., Leon-Muñoz, L. M., Gasse, C., Moore, N., Droz, C., Lassalle, R., Aakjær, M., Andersen, M., De Bruin, M. L., Groenwold, R., ... Gardarsdottir, H. (2019). Incidence of direct oral anticoagulant use in patients with nonvalvular atrial fibrillation and characteristics of users in 6 European countries (2008–2015): A cross-national drug utilization study. British Journal of Clinical Pharmacology, 85(11), 2524-2539. https://doi.org/10.1111/bcp.14071
https://dspace.library.uu.nl/bitstream/handle/1874/390826/Ib_ez_et_al_2019_British_Journal_of_Clinical_Pharmacology.pdf?sequence=1
van Hunsel, F., Gardarsdottir, H., de Boer, A., & Kant, A. (2019). Measuring the impact of pharmacovigilance activities, challenging but important. British Journal of Clinical Pharmacology, 85(10), 2235-2237. https://doi.org/10.1111/bcp.14042
https://dspace.library.uu.nl/bitstream/handle/1874/388353/Hunsel_et_al_2019_British_Journal_of_Clinical_Pharmacology.pdf?sequence=1
Hempenius, M., Groenwold, R. H. H., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2019). Amiodarone use and the risk of acute pancreatitis: Influence of different exposure definitions. Pharmacoepidemiology and Drug Safety, 28(12), 1563-1571. https://doi.org/10.1002/pds.4851
https://dspace.library.uu.nl/bitstream/handle/1874/394338/Amiodarone.pdf?sequence=1
Minnema, L. A., Giezen, T. J., Souverein, P. C., Egberts, T. C. G., Leufkens, H. G. M., & Gardarsdottir, H. (2019). Exploring the Association between Monoclonal Antibodies and Depression and Suicidal Ideation and Behavior: A VigiBase Study. Drug Safety, 42(7), 887-895. https://doi.org/10.1007/s40264-018-00789-9
https://dspace.library.uu.nl/bitstream/handle/1874/384882/Minnema2019_Article_ExploringTheAssociationBetween.pdf?sequence=1
Bekker, C., van den Bemt, B., Egberts, T. CG., Bouvy, M., & Gardarsdottir, H. (2019). Willingness of patients to use unused medication returned to the pharmacy by another patient: a cross-sectional survey. BMJ Open, 9(5), Article e024767. https://doi.org/10.1136/bmjopen-2018-024767
https://dspace.library.uu.nl/bitstream/handle/1874/384681/e024767.full.pdf?sequence=1
Bekker, C. L., Gardarsdottir, H., Egberts, A. C. G., Molenaar, H. A., Bouvy, M. L., van den Bemt, B. J. F., & Hövels, A. M. (2019). What does it cost to redispense unused medications in the pharmacy? A micro-costing study. BMC Health Services Research, 19(1), Article 243. https://doi.org/10.1186/s12913-019-4065-6
https://dspace.library.uu.nl/bitstream/handle/1874/384680/What_does_it_cost.pdf?sequence=1
Wouters, H., Rhebergen, D., Vervloet, M., Egberts, A., Taxis, K., van Dijk, L., & Gardarsdottir, H. (2019). Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants. Drugs, 79(6), 647-654. https://doi.org/10.1007/s40265-019-01107-y
https://dspace.library.uu.nl/bitstream/handle/1874/384915/Wouters2019_Article_DistinctProfilesOnSubjectiveAn.pdf?sequence=1
Ampadu, H. H., Asante, K. P., Bosomprah, S., Akakpo, S., Hugo, P., Gardarsdottir, H., Leufkens, H. G. M., Kajungu, D., & Dodoo, A. N. O. (2019). Prescribing patterns and compliance with World Health Organization recommendations for the management of severe malaria: A modified cohort event monitoring study in public health facilities in Ghana and Uganda. Malaria Journal, 18(36), Article 36. https://doi.org/10.1186/s12936-019-2670-9
https://dspace.library.uu.nl/bitstream/handle/1874/379620/Prescribing_patterns.pdf?sequence=1
Bekker, C. L., Kalicharan, R. W., Melis, E. J., Gardarsdottir, H., van den Bemt, B. J. F., Bouvy, M. L., van Maarseveen, E. M., & Egberts, A. C. G. (2019). Redispensing of unused HIV post-exposure prophylaxis for medical students. Travel Medicine and Infectious Disease, 29, 82-83. https://doi.org/10.1016/j.tmaid.2019.02.005
https://dspace.library.uu.nl/bitstream/handle/1874/382242/1_s2.0_S1477893918302990_main.pdf?sequence=1
Minnema, L. A., Giezen, T. J., Gardarsdottir, H., Egberts, T. C. G., Leufkens, H. G. M., & Mantel-Teeuwisse, A. K. (2019). Post-marketing dosing changes in the label of biologicals. British Journal of Clinical Pharmacology, 85(4), 715-721. https://doi.org/10.1111/bcp.13843
https://dspace.library.uu.nl/bitstream/handle/1874/382241/Minnema_et_al_2019_British_Journal_of_Clinical_Pharmacology.pdf?sequence=1
Bekker, C. L., Melis, E. J., Egberts, A. C. G., Bouvy, M. L., Gardarsdottir, H., & van den Bemt, B. J. F. (2019). Quantity and economic value of unused oral anti-cancer and biological disease-modifying anti-rheumatic drugs among outpatient pharmacy patients who discontinue therapy. Research in Social and Administrative Pharmacy, 15(1), 100-105. https://doi.org/10.1016/j.sapharm.2018.03.064
https://dspace.library.uu.nl/bitstream/handle/1874/428105/1_s2.0_S1551741117308781_main.pdf?sequence=1
Vlieland, N. D., van den Bemt, B., van Riet-Nales, D. A., Bouvy, M. L., Egberts, T., & Gardarsdottir, H. (2019). Actual versus recommended storage temperatures of oral anticancer medicines at patients' homes. Journal of Oncology Pharmacy Practice, 25(2), 382-389. https://doi.org/10.1177/1078155217741767
https://dspace.library.uu.nl/bitstream/handle/1874/382269/Actual.pdf?sequence=1

Professional publications

Koster, E., Philbert, D., & Gardarsdottir, H. (2019). Diabetespatiënt heeft hulp nodig bij keuze geschikte app: Zelfmanagement bij diabetes wordt als positief ervaren . Pharmaceutisch Weekblad, 17, 18-19.

2018

Scholarly publications

Orsel, K., Taipale, H., Tolppanen, A.-M., Koponen, M., Tanskanen, A., Tiihonen, J., Gardarsdottir, H., & Hartikainen, S. (2018). Psychotropic drug use and psychotropic polypharmacy among persons with Alzheimer's disease. 294. Abstract from 34th International conference on Pharmacoepidemiology & Therapeutic Risk Management, Prague, Czech Republic. https://doi.org/10.1002/pds.4629
Minnema, L., Giezen, T., Souverein, P., Egberts, T., Leufkens, B., & Gardarsdottir, H. (2018). Exploring the association between monoclonal antibodies and depression and suicidal ideation and behavior: A vigibase study. Drug Safety, 41(11), 1197-1198. https://doi.org/10.1007/s40264-018-0719-2
Kant, A., Peters, L., Gardarsdottir, H., & Van Hunsel, F. (2018). Opportunities and pitfalls when measuring harm reduction through pharmacovigilance activities. Drug Safety, 41(11), 1106-1107. https://doi.org/10.1007/s40264-018-0719-2
Van Hunsel, F., Peters, L., Gardarsdottir, H., & Kant, A. (2018). Measuring the impact of pharmacovigilance activities on public health; Practical example of 3 signals. Pharmacoepidemiology and Drug Safety, 27, 511-512. https://doi.org/10.1002/pds.4629
Minnema, L. A., Giezen, T. J., Souverein, P. C., Egberts, T. C. G., Leufkens, H. G. M., & Gardarsdottir, H. (2018). Exploring the association between monoclonal antibodies and depression and suicidal ideation and behaviour: A VigiBase study. Pharmacoepidemiology and Drug Safety, 27, 50. https://doi.org/10.1002/pds.4629
Zhang, Y., De Boer, A., Gardarsdottir, H., Van Den Ham, H. A., Maitland-Van Der Zee, A. H., & Souverein, P. C. (2018). Concurrent use of DOACs and pharmacodynamic interacting drugs is associated with an increased risk of major bleeding compared with patients using DOACs alone: Nested case-control study in UK CPRD. Pharmacoepidemiology and Drug Safety, 27, 465-466. https://doi.org/10.1002/pds.4629
https://dspace.library.uu.nl/bitstream/handle/1874/428143/Pages_from_Pharmacoepidemiology_and_Drug_2018_Abstract2.pdf?sequence=1
Hempenius, M., Gardarsdottir, H., De Boer, A., Klungel, O., & Groenwold, R. (2018). Amiodarone use and the risk of acute pancreatitis: Influence of different exposure definitions on risk estimation. Pharmacoepidemiology and Drug Safety, 27, 7. https://doi.org/10.1002/pds.4629
https://dspace.library.uu.nl/bitstream/handle/1874/428135/Pages_from_Pharmacoepidemiology_and_Drug_2018_Abstract.pdf?sequence=1
Vlieland, N. D., Van Den Bemt, B. J. F., Bekker, C. L., Bouvy, M. L., Egberts, A. C. G., & Gardarsdottir, H. (2018). The compliance with drug storage recommendations of elderly patients. International Journal of Clinical Pharmacy, 40(1), 238-239. https://doi.org/10.1007/s11096-017-0565-9
Bekker, C. L., Gardarsdottir, H., Egberts, A. C. G., Bouvy, M. L., & van den Bemt, B. J. F. (2018). Pharmacists' Activities to Reduce Medication Waste: An International Survey. Pharmacy, 6(3), Article 94. https://doi.org/10.3390/pharmacy6030094
https://dspace.library.uu.nl/bitstream/handle/1874/369801/pharmacy_06_00094.pdf?sequence=1
Orsel, K., Taipale, H., Raatikainen, S., Lampela, P., Tolppanen, A.-M., Koponen, M., Tanskanen, A., Tiihonen, J., Gardarsdottir, H., & Hartikainen, S. (2018). Antipsychotic Use and the Risk of Initiating Medication for Benign Prostate Hyperplasia in Persons With Alzheimer Disease: A Matched Cohort Study. Journal of Clinical Psychopharmacology, 38(5), 494-497. https://doi.org/10.1097/JCP.0000000000000928
https://dspace.library.uu.nl/bitstream/handle/1874/369789/Antipsychotic.pdf?sequence=3
Orsel, K., Taipale, H., Tolppanen, A.-M., Koponen, M., Tanskanen, A., Tiihonen, J., Gardarsdottir, H., & Hartikainen, S. (2018). Psychotropic drugs use and psychotropic polypharmacy among persons with Alzheimer's disease. European Neuropsychopharmacology, 28(11), 1260-1269. https://doi.org/10.1016/j.euroneuro.2018.04.005
https://dspace.library.uu.nl/bitstream/handle/1874/373320/1_s2.0_S0924977X18302906_main.pdf?sequence=1
Bekker, C. L., Gardarsdottir, H., Egberts, A., Bouvy, M., & van den Bemt, B. J. F. (2018). Pharmacists' activities to reduce medication waste: An international survey. 228. Abstract from 46th ESCP symposium on clinical pharmacy “Science meets practice: towards evidence-based clinical pharmacy services”, Heidelberg, Germany. https://doi.org/10.1007/s11096-017-0565-9
Vlieland, N. D., Van Den Bemt, B. J. F., van Riet-Nales, D. A., Bouvy, M. L., Egberts, A. C. G., & Gardarsdottir, H. (2018). Actual versus recommended storage temperatures of oral anticancer drugs. 296. Abstract from ESCP symposium on clinical pharmacy, Heidelberg, Germany. https://doi.org/10.1007/s11096-017-0565-9
Abdullah-Koolmees, H., Gardarsdottir, H., Egberts, T. C. G., Minnema, L. A., Elmi, K., Stoker, L. J., Vuyk, J., Goedhard, L. E., & Heerdink, E. R. (2018). Predicting rehospitalization in patients treated with antipsychotics: a prospective observational study. Therapeutic Advances in Psychopharmacology, 8(8), 213-229. https://doi.org/10.1177/2045125318762373
https://dspace.library.uu.nl/bitstream/handle/1874/368306/2045125318762373.pdf?sequence=1
Bekker, C., Gardarsdottir, H., Melis, E. J., Egberts, A. C., Bouvy, M. L., & Van Den Bemt, B. J. (2018). Quantity and economic value of unused oral cancer drugs among patients who discontinue their therapy. International Journal of Clinical Pharmacy, 40(3), 732. https://doi.org/10.1007/s11096-018-0637-5
Ampadu, H. H., Dodoo, A. N. O., Bosomprah, S., Akakpo, S., Hugo, P., Gardarsdottir, H., Leufkens, H. G. M., Kajungu, D., & Asante, K. P. (2018). Safety Experience During Real-World Use of Injectable Artesunate in Public Health Facilities in Ghana and Uganda: Outcomes of a Modified Cohort Event Monitoring Study (CEMISA). Drug Safety, 41(9), 871-880. https://doi.org/10.1007/s40264-018-0667-x
https://dspace.library.uu.nl/bitstream/handle/1874/369769/Ampadu2018_Article_SafetyExperienceDuringReal_Wor.pdf?sequence=1
Bekker, C. L., van den Bemt, B. J. F., Egberts, A. C. G., Bouvy, M. L., & Gardarsdottir, H. (2018). Patient and medication factors associated with preventable medication waste and possibilities for redispensing. International Journal of Clinical Pharmacy, 40(3), 704-711. https://doi.org/10.1007/s11096-018-0642-8
https://dspace.library.uu.nl/bitstream/handle/1874/365201/Bekker2018_Article_PatientAndMedicationFactorsAss.pdf?sequence=1
Bekker, C. L., Gardarsdottir, H., Molenaar, E., Bouvy, M., van de Bemt, B. J. F., & Hövels, A. (2018). Cost estimation of redispensing unused medicines that are returned to the pharmacy: A micro-costing study. International Journal of Clinical Pharmacy, 40(1), 217. https://doi.org/10.1007/s11096-017-0565-9
Vlieland, N. D., Nejadnik, M. R., Gardarsdottir, H., Romeijn, S., Sediq, A. S., Bouvy, M. L., Egberts, A. C. G., van den Bemt, B. J. F., & Jiskoot, W. (2018). The Impact of Inadequate Temperature Storage Conditions on Aggregate and Particle Formation in Drugs Containing Tumor Necrosis Factor-Alpha Inhibitors. Pharmaceutical Research, 35(2), Article 42. https://doi.org/10.1007/s11095-017-2341-x
https://dspace.library.uu.nl/bitstream/handle/1874/363274/impact.pdf?sequence=1
Vlieland, N. D., van Den Bemt, B. J. F., Bekker, C. L., Bouvy, M. L., Egberts, T. C. G., & Gardarsdottir, H. (2018). Older Patients’ Compliance with Drug Storage Recommendations. Drugs and Aging, 35(3), 233-241. https://doi.org/10.1007/s40266-018-0524-8
https://dspace.library.uu.nl/bitstream/handle/1874/363273/vlieland.pdf?sequence=1

Professional publications

Vlieland, N. D., Gardarsdottir, H., Egberts, A. C. G., Bouvy, M. L., & Van Den Bemt, B. J. F. (2018). Bewaren geneesmiddelen thuis gaat vaak niet goed: Mogelijke gevolgen voor kwaliteit en effectiviteit. Pharmaceutisch Weekblad, 153(47), 10-11. https://www.pw.nl/achtergrond/2018/bewaren-geneesmiddelen-thuis-gaat-vaak-niet-goed
https://dspace.library.uu.nl/bitstream/handle/1874/428404/2018_Vleiland_Bewaren_geneesmiddelen_thuis_gaat_vaak_niet_goed_PW_Pharmaceutisch_Weekblad.pdf?sequence=1
Bekker, C. L., Gardarsdottir, H., Egberts, T. C. G., Bouvy, M. L., & Van Den Bemt, B. J. F. (2018). Heruitgifte van ongebruikte geneesmiddelen: Een kwalitatief onderzoek onder stakeholders. Pharmaceutisch Weekblad, 153(1-2), 25-27. https://www.knmp.nl/resolveuid/6031edfda9cd4bb2a60500e60ddbfae0
https://dspace.library.uu.nl/bitstream/handle/1874/428102/a1653.pdf?sequence=1

2017

Scholarly publications

Gardarsdottir, H., Kant, A., Bruin, M. L. D., CE, H., Pan, G. D., & Way, D. (2017). How to Measure the Impact of Pharmacovigilance Activities on Public Health?.
Gardarsdottir, H., Kant, A., De Bruin, M. L., Hallgren, C. E., Pan, G. D., & Way, D. (2017). How to measure the impact of pharmacovigilance activities on public health? Pharmacoepidemiology and Drug Safety, 26, 31. https://doi.org/10.1002/pds.4275
Minnema, L. A., Giezen, T. J., Gardarsdottir, H., Egberts, T. C. G., Leufkens, H. G. M., & Mantel-Teeuwisse, A. K. (2017). Post-marketing label changes in dosing information of biopharmaceuticals-different from small molecules? Pharmacoepidemiology and Drug Safety, 26, 606-607. https://doi.org/10.1002/pds.4275
Bekker, C. L., Gardarsdottir, H., Egberts, T., van de Bemt, B. J. F., & Bouvy, M. (2017). Unused medicines returned to community pharmacy: An analysis of medication waste and possibilities for redispensing. International Journal of Clinical Pharmacy, 39(1), 240. https://doi.org/10.1007/s11096-016-0404-4
https://dspace.library.uu.nl/bitstream/handle/1874/356216/10.1007_2Fs11096_016_0404_4.pdf?sequence=1
Bekker, C. L., Gardarsdottir, H., Egberts, T. C. G., Bouvy, M. L., & van den Bemt, B. J. F. (2017). Redispensing of medicines unused by patients: a qualitative study among stakeholders. International Journal of Clinical Pharmacy, 39(1), 196-204. https://doi.org/10.1007/s11096-017-0424-8
https://dspace.library.uu.nl/bitstream/handle/1874/348415/Redispensing.pdf?sequence=1

Other output

Wouters, H., Hilmer, S., van Campen, J., Van Der Meer, H., Gardarsdottir, H., Schaap, L. A., Huisman, M., Denig, P., Taxis, K., & Rhebergen, D. (2017). Trajectories of long-term exposure to anticholinergic and sedative drugs: A latent class growth analysis. 21. Poster session presented at 13th International Congress of the European Union Geriatric Medicine Society, Nice, France. https://doi.org/10.1016/S1878-7649(17)30178-X
Vlieland, N. D., Van Den Bemt, B. J. F., Bekker, C. L., Bouvy, M. L., Egberts, T. C. G., & Gardarsdottir, H. (2017). Patient compliance with drug storage recommendations. Pharmacoepidemiology and Drug Safety, 26(S2), 516-517. Article 854. https://doi.org/10.1002/pds.4275

2016

Scholarly publications

Bekker, C., Gardarsdottir, H., Egberts, A., Bouvy, M., & Van Den Bemt, B. (2016). Stakeholders' views on and their minimal requirements for redispensing unused medicines: A qualitative study. International Journal of Clinical Pharmacy, 38(6), 591. https://doi.org/10.1007/s11096-015-0240-y
https://dspace.library.uu.nl/bitstream/handle/1874/428108/s11096_015_0240_y.pdf?sequence=1
van Dijk, S. M., Gardarsdottir, H., Wassenberg, M. W. M., Oosterheert, J. J., de Groot, M. C. H., & Rockmann, H. (2016). The High Impact of Penicillin Allergy Registration in Hospitalized Patients. Journal of Allergy and Clinical Immunology: In Practice, 4(5), 926-931. https://doi.org/10.1016/j.jaip.2016.03.009
https://dspace.library.uu.nl/bitstream/handle/1874/346117/penicillin.pdf?sequence=1
Abdullah, H., Gardarsdottir, H., Yazir, D., Stoker, L. J., Vuyk, J., Egberts, T. C. G., & Heerdink, E. R. (2016). Zorgen om medicatiegebruik psychiatrische patient na ontslag: Bijna 70% patiënten stopt met een of meer geneesmiddelen. Pharmaceutisch Weekblad, 151(7), 14-15. https://www.pw.nl/achtergrond/2016/zorgen-om-medicatiegebruik-psychiatrische-patient-na-ontslag
https://dspace.library.uu.nl/bitstream/handle/1874/428405/2016_Abdullah_Zorgen_medicatiegebruik_ontslag_psychiatrie_PW.pdf?sequence=1
Wouters, H., Amin, D. F. H., Taxis, K., Heerdink, E. R., Egberts, A. C. G., & Gardarsdottir, H. (2016). Associations between personality traits and adherence to antidepressants assessed through self-report, electronic monitoring, and pharmacy dispensing data: A Pilot Study. Journal of Clinical Psychopharmacology, 36(5), 465-471. https://doi.org/10.1097/JCP.0000000000000541
https://dspace.library.uu.nl/bitstream/handle/1874/343148/associations.pdf?sequence=1
Klungel, O. H., Kurz, X., de Groot, M. C. H., Schlienger, R. G., Tcherny-Lessenot, S., Grimaldi, L., Ibáñez, L., Groenwold, R. H. H., Reynolds, R. F., Alvarez, Y., Candore, G., Durand, J., Slattery, J., Hasford, J., Rottenkolber, M., Schmiedl, S., de Abajo Iglesias, F., Gil, M., Gonzalez, R., ... On behalf of the members of work-package 2 of PROTECT (2016). Multi-centre, multi-database studies with common protocols: Lessons learnt from the IMI PROTECT project. Pharmacoepidemiology and Drug Safety, 25(supplement S1), 156-165. https://doi.org/10.1002/pds.3968
https://dspace.library.uu.nl/bitstream/handle/1874/336990/Klungel_et_al_2016_Pharmacoepidemiology_and_Drug_Safety.pdf?sequence=1
De Groot, M. C. H., Candore, G., Uddin, J., Souverein, P., Ali, M. S., Belitser, S., Huerta, C., Groenwold, R. H. H., Alvarez, Y., Slattery, J., Korevaar, J., Hoes, A. W., Roes, K. C. B., de Boer, A., Douglas, I. J., Schlienger, R. G., Reynolds, R., Klungel, O. H., & Gardarsdottir, H. (2016). Case-only designs for studying the association of antidepressants and hip or femur fracture. Pharmacoepidemiology and Drug Safety, 25(Supplement S1), 103-113. https://doi.org/10.1002/pds.3850
https://dspace.library.uu.nl/bitstream/handle/1874/336989/Groot_et_al_2016_Pharmacoepidemiology_and_Drug_Safety.pdf?sequence=1
Ali, M. S., Groenwold, R. H. H., Belitser, S., Souverein, P. C., Martín, E., Gatto, N. M., Huerta, C., Gardarsdottir, H., Roes, K. C. B., Hoes, A. W., de Boer, A., & Klungel, O. H. (2016). Methodological comparison of marginal structural model, time-varying Cox regression, and propensity score methods: the example of antidepressant use and the risk of hip fracture. Pharmacoepidemiology and Drug Safety, 25(Suppl 1), 114-121. https://doi.org/10.1002/pds.3864
https://dspace.library.uu.nl/bitstream/handle/1874/336981/Drug_Safety_1_.pdf?sequence=1
Uddin, M. J., Groenwold, R. H. H., de Boer, A., Gardarsdottir, H., Martin, E., Candore, G., Belitser, S. V., Hoes, A. W., Roes, K. C. B., & Klungel, O. H. (2016). Instrumental variables analysis using multiple databases: An example of antidepressant use and risk of hip fracture. Pharmacoepidemiology and Drug Safety, 25(Supplement S1), 122-131. https://doi.org/10.1002/pds.3863
https://dspace.library.uu.nl/bitstream/handle/1874/336977/Uddin_et_al_2016_Pharmacoepidemiology_and_Drug_Safety.pdf?sequence=1
Souverein, P. C., Abbing-Karahagopian, V., Martin, E., Huerta, C., de Abajo, F., Leufkens, H. G. M., Candore, G., Alvarez, Y., Slattery, J., Miret, M., Requena, G., Gil, M. J., Groenwold, R. H. H., Reynolds, R., Schlienger, R. G., Logie, J. W., de Groot, M. C. H., Klungel, O. H., van Staa, T. P., ... Gardarsdottir, H. (2016). Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures. Pharmacoepidemiology and Drug Safety, 25 (Suppl 1), 88-102. https://doi.org/10.1002/pds.3862
https://dspace.library.uu.nl/bitstream/handle/1874/336971/Souverein_et_al_2016_Pharmacoepidemiology_and_Drug_Safety.pdf?sequence=1
Vlieland, N. D., Gardarsdottir, H., Bouvy, M. L., Egberts, T. C. G., & van den Bemt, B. J. F. (2016). The majority of patients do not store their biologic disease-modifying antirheumatic drugs within the recommended temperature range. Rheumatology (Oxford, England), 55, 704-709. https://doi.org/10.1093/rheumatology/kev394
https://dspace.library.uu.nl/bitstream/handle/1874/330999/majority.pdf?sequence=1
Requena, G., Logie, J., Martin, E., Boudiaf, N., González González, R., Huerta, C., Alvarez, A., Webb, D., Bate, A., García Rodríguez, L. A., Reynolds, R., Schlienger, R., Gardarsdottir, H., de Groot, M., Klungel, O. H., de Abajo, F., & Douglas, I. J. (2016). Do case-only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines. Pharmacoepidemiology and Drug Safety, 25(Suppl. S1), 79–87. https://doi.org/10.1002/pds.3822
https://dspace.library.uu.nl/bitstream/handle/1874/345870/designs.pdf?sequence=1
Requena, G., Huerta, C., Gardarsdottir, H., Logie, J., González-González, R., Abbing-Karahagopian, V., Miret, M., Schneider, C., Souverein, P. C., Webb, D., Afonso, A., Boudiaf, N., Martin, E., Oliva, B., Alvarez, A., De Groot, M. C. H., Bate, A., Johansson, S., Schlienger, R., ... de Abajo, F. J. (2016). Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project. Pharmacoepidemiology and Drug Safety, 25(Suppl. S1), 66–78. https://doi.org/10.1002/pds.3816
https://dspace.library.uu.nl/bitstream/handle/1874/345867/fractures.pdf?sequence=1
Huerta, C., Abbing-Karahagopian, V., Requena, G., Oliva, B., Alvarez, Y., Gardarsdottir, H., Miret, M., Schneider, C., Gil, M., Souverein, P. C., De Bruin, M. L., Slattery, J., De Groot, M. C. H., Hesse, U., Rottenkolber, M., Schmiedl, S., Montero, D., Bate, A., Ruigomez, A., ... de Abajo, F. J. (2016). Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project. Pharmacoepidemiology and Drug Safety, 25(S1), 56–65. https://doi.org/10.1002/pds.3825
https://dspace.library.uu.nl/bitstream/handle/1874/316727/Exposure.pdf?sequence=3

2015

Scholarly publications

Vlieland, N. D., Gardarsdottir, H., Bouvy, M. L., Egberts, A. C., & Van Den Bemt, B. J. (2015). Majority of patients do not store their biological disease modifying antirheumatic drugs within recommended temperature range. Annals of the Rheumatic Diseases, 74, 710-711. https://doi.org/10.1136/annrheumdis-2015-eular.3074
Abbing-Karahagopian, V., Souverein, P. C., Korevaar, J. C., Leufkens, H. G. M., Egberts, T. C. G., Gardarsdottir, H., & De Bruin, M. L. (2015). Concomitant medication use and its implications on the hazard pattern in pharmacoepidemiological studies: Example of antidepressants, benzodiazepines and fracture risk. Epidemiology Biostatistics and Public Health, 12(3), Article e11273. https://doi.org/10.2427/11273
https://dspace.library.uu.nl/bitstream/handle/1874/428386/galimberti_11273_19075_2_PB.pdf?sequence=1
Thengilsdõttir, G., Pottegård, A., Linnet, K., Halldõrsson, M., Almarsdõttir, A. B., & Gardarsdõttir, H. (2015). Do patients initiate therapy? Primary non-adherence to statins and antidepressants in Iceland. International Journal of Clinical Practice, 69(5), 597-603. https://doi.org/10.1111/ijcp.12558
Uddin, J., Groenwold, R. H. H., Ali, M. S., Candore, G., De Groot, M. C. H., Souverein, P. C., Alvarez, Y., Belitser, S., Hoes, A. W., De Boer, A., Roes, K. C. B., Klungel, O. H., & Gardarsdottir, H. (2015). Application of the self-controlled case series design in pharmacoepidemiological studies: A cautionary note. European Journal of Epidemiology, 30(8), 903. https://doi.org/10.1007/s10654-015-0072-z
https://dspace.library.uu.nl/bitstream/handle/1874/338006/application.pdf?sequence=1
Uddin, M. J., Groenwold, R. H. H., Ali, M. S., Candore, G., De Groot, M. C. H., Souverein, P. C., Alvarez, Y., Belitser, S., Hoes, A. W., De Boer, A., Roes, K. C. B., Klungel, O., & Gardarsdottir, H. (2015). Impact of violations of the assumptions of the self-controlled case series design in pharmacoepidemiological studies: An example of antidepressants use and the risk of hip fracture. Pharmacoepidemiology and Drug Safety, 24, 2-3. https://doi.org/10.1002/pds.3838
https://dspace.library.uu.nl/bitstream/handle/1874/331017/violations.pdf?sequence=1
Abdullah, H., Gardarsdottir, H., Yazir, D., Stoker, L. J., Vuyk, J., Egberts, T. C. G., & Heerdink, E. R. (2015). Medication Discontinuation in Patients After Discharge From a Psychiatric Hospital. Annals of Pharmacotherapy, 49(10), 1085-95. https://doi.org/10.1177/1060028015593763
https://dspace.library.uu.nl/bitstream/handle/1874/329744/Ann_Pharmacother_2015_Abdullah_Koolmees_1085_95.pdf?sequence=1
Ferrer, P., Sabaté, M., Ballarín, E., Rottenkolber, M., Schmiedl, S., Amelio, J., De Abajo, F., Ruigómez, A., Gil, M., Huerta, C., Gardarsdottir, H., Afonso, A., Klungel, O., De Groot, M., Schlinger, R., Reynolds, R., & Ibáñez, L. (2015). Measuring drug use: Differences between medical records and healthcare utilisation data bases. Clinical Therapeutics, 37(8), 75. https://doi.org/10.1016/j.clinthera.2015.05.216

2014

Scholarly publications

Abbing-Karahagopian, V., Huerta, C., Souverein, P. C., De Abajo, F., Leufkens, H. G. M., Slattery, J., Alvarez, Y., Miret, M., Gil, M., Oliva, B., Hesse, U., Requena, G., De Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlienger, R. G., De Groot, M. C. H., Klungel, O. H., ... De Bruin, M. L. (2014). Antidepressant prescribing in five European countries: Application of common definitions to assess the prevalence, clinical observations, and methodological implications. European Journal of Clinical Pharmacology, 70(7), 849-857. https://doi.org/10.1007/s00228-014-1676-z
Ali, MS., De Groot, M., Candore, G., Groenwold, R. H. H., Souverein, P. C., Alvarez, Y., Uddin, M. J., Hoes, A. W., De Boer, A., Klungel, O. H., & Gardarsdottir, H. (2014). Antidepressantuse and the risk of hip fracture: A self-controlled case series approach in two primary care databases. Pharmacoepidemiology and Drug Safety, 23, 385. https://doi.org/10.1002/pds.3701
Requena, G., Abbing-Karahagopian, V., Huerta, C., De Bruin, M. L., Alvarez, Y., Miret, M., Hesse, U., Gardarsdottir, H., Souverein, P. C., Slattery, J., Schneider, C., Rottenkolber, M., Schmiedl, S., Gil, M., De Groot, M. C. H., Bate, A., Ruigómez, A., García Rodríguez, L. A., Johansson, S., ... De Abajo, F. J. (2014). Incidence rates and trends of hip/femur fractures in five European countries: Comparison using e-healthcare records databases. Calcified Tissue International, 94(6), 580-589. https://doi.org/10.1007/s00223-014-9850-y
Wouters, H., Bouvy, M. L., Van Geffen, E. C., Gardarsdottir, H., Stiggelbout, A. M., & Van Dijk, L. (2014). Antidepressants in primary care: patients' experiences, perceptions, self-efficacy beliefs, and nonadherence. Patient Preference and Adherence, 8, 179-90. https://doi.org/10.2147/PPA.S53748
https://dspace.library.uu.nl/bitstream/handle/1874/303309/PPA_53748_antidepressants_in_primary_care_patients_experiences_and_p_021014.pdf?sequence=1
Gardarsdottir, H., Stoker, L. J., Vuyk, J., Egberts, T. C. G., Heerdink, E. R., & Abdullah, H. (2014). Discontinuation of somatic medication during psychiatric hospitalization. Annals of Pharmacotherapy, 48(11), 1415-24. https://doi.org/10.1177/1060028014544897
Wouters, H., Van Dijk, L., Van Geffen, E. C. G., Gardarsdottir, H., Stiggelbout, A. M., & Bouvy, M. L. (2014). Primary-care patients' trade-off preferences with regard to antidepressants. Psychological Medicine, 44(11), 2301–2308. https://doi.org/10.1017/S0033291713003103

Other output

Ali, M. S., De Groot, M., Candore, G., Groenwold, R. H. H., Souverein, P. C., Alvarez, Y., Uddin, M. J., Hoes, A. W., de Boer, A., Klungel, O. H., & Gardarsdottir, H. (2014). Antidepressant Use and the Risk of Hip Fracture: A Self-Controlled Case Series Approach in Two Primary Care Databases. Pharmacoepidemiology and Drug Safety, 23, 385-385.
Requena, G., Huerta, C., Gardarsdottir, H., Miret, M., Martin, E., Souverein, P. C., Schneider, C., Gonzalez-Gonzalez, R., Bate, A., Alvarez, Y., Montero, D., Garcia-Rodriguez, L. A., Reynolds, R., Schlienger, R. G., de Groot, M. C. H., Klungel, O. H., & de Abajo, F. J. (2014). Risk of Hip Fractures Associated with Benzodiazepines: Common Methodology But Different Results in a Multi-Site Cohort Study. The PROTECT Project. Pharmacoepidemiology and Drug Safety, 23(S1), 383-384. Article 715.
https://dspace.library.uu.nl/bitstream/handle/1874/304517/715xx.pdf?sequence=1
Abbing-Karahagopian, V., Souverein, P., Martin, E., Huerta, C., de Abajo, F., Leufkens, H., Candore, G., Alvarez, Y., Slattery, J., Miret, M., Requena, G., Gil, M., Groenwold, R., Reynolds, R., Schlienger, R., de Groot, M., Klungel, O. H., van Staa, T., Egberts, T., ... Gardarsdottir, H. (2014). Understanding Inconsistent Results from Observational Pharmacoepidemiological Studies: the Case of Antidepressant Use and Risk of Hip Fracture. Pharmacoepidemiology and Drug Safety, 23, 36-36.
Souverein, P. C., & Gardarsdottir, H. (2014). (Non)availability of Dosage Instructions in Electronic Health Care Databases and Exposure (mis)classification: the Example of Antidepressants. Pharmacoepidemiology and Drug Safety, 23, 36-37.
Thengilsdottir, G., Pottegard, A., Almarsdottir, A. B., & Gardarsdottir, H. (2014). Do Patients Initiate Therapy? Primary Non-Adherence to Statins and Antidepressant in Iceland. Pharmacoepidemiology and Drug Safety, 23, 200-200.
Klungel, O., De Groot, M., Gardarsdottir, H., Brauer, R., Grimaldi-Bensouda, L., Kurz, X., Gasse, C., & Reynolds, R. (2014). Impact of methodological choices on findings from pharmacoepidemiological studies: Final results of the IMI-protect (pharmacoepidemiological research on outcomes of therapeutics by a European consortium) project. Pharmacoepidemiology and Drug Safety, 23(S1), 43. Article 78. https://doi.org/10.1002/pds.3701
https://dspace.library.uu.nl/bitstream/handle/1874/304121/701.pdf?sequence=1
De Groot, M. C. H., Belitser, S. V., Souverein, P. C., Groenwold, R. H. H., Candore, G., Alvarez, Y., Schlienger, R. G., Reynolds, R., Klungel, O. H., & Gardarsdottir, H. (2014). Impact of varying control moment selection in a case-crossover (CCO) study on antidepressant drug (AD) use and hip/femur fracture (HFF) in protect. Pharmacoepidemiology and Drug Safety, 23(S1), 407-408. Article 758. https://doi.org/10.1002/pds.3701
https://dspace.library.uu.nl/bitstream/handle/1874/304119/01.pdf?sequence=1
Souverein, P. C., De Groot, M. C. H., Martin, E., Huerta, C., Candore, G., Alvarez, Y., Slattery, J., Schlienger, R. G., Reynolds, R., Klungel, O. H., & Gardarsdottir, H. (2014). No impact of adjusting for lifestyle factors or general practice on risk estimates for the association between antidepressants and hip/femur fracture. Pharmacoepidemiology and Drug Safety, 23(S1), 384-385. Article 716. https://doi.org/10.1002/pds.3701
https://dspace.library.uu.nl/bitstream/handle/1874/304599/1.pdf?sequence=1
Requena, G., Logie, J., González-González, R., Gardarsdottir, H., Afonso, A., Souverein, P. C., Merino, E. M., Boudiaf, N., Huerta, C., Bate, A., Alvarez, Y., García-Rodríguez, L. A., Reynolds, R., Schlienger, R. G., De Groot, M. C. H., Klungel, O. H., & De Abajo, F. J. (2014). Risk of hip fractures associated with benzodiazepines: Applying common protocol to a multi-database nested case-control study. The protect project. Pharmacoepidemiology and Drug Safety, 23, 44. Article 80. https://doi.org/10.1002/pds.3701
https://dspace.library.uu.nl/bitstream/handle/1874/304512/44.pdf?sequence=1
Uddin, M. J., Groenwold, R. H. H., De Boer, A., Gardarsdottir, H., Martin, E., Candore, G., Belitser, S. V., Hoes, A. W., Roes, K. C. B., & Klungel, O. H. (2014). Instrumental variable analysis using multiple databases: An example of antidepressant use and risk of hip/femur fracture. Pharmacoepidemiology and Drug Safety, 23(S1), 30-31. Article 55. https://doi.org/10.1002/pds.3701
https://dspace.library.uu.nl/bitstream/handle/1874/304263/30_31pdf.pdf?sequence=1
Ali, M. S., Groenwold, R. H. H., Belitser, S. V., Souverein, P. C., Gardarsdottir, H., Hoes, A. W., De Boer, A., & Klungel, O. H. (2014). Antidepressant use and risk of hip fracture: A comparison of marginal structural models, conventional regression and propensity score methods. Pharmacoepidemiology and Drug Safety, 23(S1), 199. Article 377. https://doi.org/10.1002/pds.3701
https://dspace.library.uu.nl/bitstream/handle/1874/303760/Pages_from_pds3701.pdf?sequence=1
Ryan, P., Anderson, M., Schuemie, M., Burke, A., Haynes, K., Man, K., Gardarsdottir, H., & De Bruin, M. L. (2014). The common data model: Lessons from past projects and ongoing initiatives. Pharmacoepidemiology and Drug Safety, 23(S1), 361-362. https://doi.org/10.1002/pds.3701

2013

Scholarly publications

Abbing-Karahagopian, V., Huerta, C., Souverein, P. C., de Abajo, F., Leufkens, H. G. M., Slattery, J., Alvarez, Y., Montserrat, M., Gil, M., Hesse, U., Requena, G., de Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlinger, R., de Groot, M., Klungel, O. H., van Staa, T. P., ... De Bruin, M. L. (2013). Antidepressant Prescribing in Five European Countries: Application of Common Methods to Assess the Variation in Prevalence. Pharmacoepidemiology and Drug Safety.
Requena, G., Abbing-Karahagopian, V., Huerta, C., De Bruin, M. L., Alvarez, Y., Miret, M., Hesse, U., Gardarsdottir, H., Souverein, P., Slattery, J., Schneider, C., Rottenkolber, M., Schmiedl, S., Gil, M., De Groot, M. C. H., Bate, A., Ruigomez, A., Garcia, L. A., Johanson, S., ... De Abajo, F. J. (2013). Trends in Incidence Rates (IR) of Hip/Femur Fractures in Five European Countries: A Comparison Using Electronic Health Care Records (e-HCR). Pharmacoepidemiology and Drug Safety, 22, 408-409.
Huerta, C., Abbing-Karahagopian, V., Requena, G., Oliva, B., Alvarez, Y., Gardarsdottir, H., Miret, M., Schneider, C., Gil, M., Souverein, P., Slattery, J., De Groot, M. C. H., Hesse, U., Rottenkolber, M., Schmiedl, S., Montero, D., Bate, A., Ruigomez, A., Garcia, L. A., ... De Abajo, F. J. (2013). Prevalence of Use of Benzodiazepines and Related Drugs in Seven European Databases: A Cross-National Descriptive Study from the PROTECT-EU Project. Pharmacoepidemiology and Drug Safety, 22, 472-472.
Abbing-Karahagopian, V., Huerta, C., Souverein, P. C., De Abajo, F., Leufkens, H. G. M., Slattery, J., Alvarez, Y., Montserrat, M., Gil, M., Hesse, U., Requena, G., De Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlinger, R., De Groot, M. C. H., Klungel, O. H., Van Staa, T. P., ... De Bruin, M. L. (2013). Antidepressant prescribing in five european countries: Application of common methods to assess the variation in prevalence. Pharmacoepidemiology and Drug Safety, 22, 279-280. https://doi.org/10.1002/pds.3512
Huerta, C., Abbing-Karahagopian, V., Requena, G., Oliva, B., Alvarez, Y., Gardarsdottir, H., Miret, M., Schneider, C., Gil, M., Souverein, P., Slattery, J., De Groot, M. C. H., Hesse, U., Rottenkolber, M., Schmiedl, S., Montero, D., Bate, A., Ruigomez, A., García, L. A., ... De Abajo, F. J. (2013). Prevalence of use of benzodiazepines and related drugs in seven european databases: A cross-national descriptive study from the protect-eu project. Pharmacoepidemiology and Drug Safety, 22, 472. https://doi.org/10.1002/pds.3512
Thengilsdottir, G., Gardarsdottir, H., Almarsdottir, A. B., McClure, C. B., & Heerdink, E. R. (2013). The association between lifting an administrative restriction on antidepressant dispensing and treatment patterns in Iceland. Health Policy, 111(2), 193-199. https://doi.org/10.1016/j.healthpol.2013.03.002
Abdullah-Koolmees, H., Gardarsdottir, H., Stoker, L. J., Vuyk, J., Egberts, A. C. G., & Heerdink, E. R. (2013). Prevalence of medication use for somatic disease in institutionalized psychiatric patients. Pharmacopsychiatry, 46(7), 274-280. https://doi.org/10.1055/s-0033-1354405
Abdullah-Koolmees, H., Gerbranda, T., Deneer, V. H. M., Tjoeng, M. M., De Ridder, A. J., Gardarsdottir, H., & Heerdink, E. R. (2013). Discontinuation of anticoagulant care during admission to a psychiatric hospital. European Journal of Clinical Pharmacology, 69(4), 1025-9. https://doi.org/10.1007/s00228-012-1398-z

Other output

Abbing-Karahagopian, V., Huerta, C., Souverein, P. C., de Abajo, F., Leufkens, H. G. M., Slattery, J., Alvarez, Y., Montserrat, M., Gil, M., Hesse, U., Requena, G., de Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlinger, R., de Groot, M., Klungel, O. H., van Staa, T. P., ... De Bruin, M. L. (2013). Antidepressant Prescribing in Five European Countries: Application of Common Methods to Assess the Variation in Prevalence. Pharmacoepidemiology and Drug Safety, 22, 279-280.
De Groot, M. C. H., Schlienger, R., Reynolds, R., Gardarsdottir, H., Juhaeri, J., Hesse, U., Gasse, C., Rottenkolber, M., Schuerch, M., Kurz, X., & Klungel, O. H. (2013). Improving consistency in findings from pharmacoepidemiological studies: The IMI-protect (Pharmacoepidemiological research on outcomes of therapeutics by a European consortium) project. Pharmacoepidemiology and Drug Safety, 22(s1), 370. Article 738. https://doi.org/10.1002/pds.3512
Requena, G., Abbing-Karahagopian, V., Huerta, C., De Bruin, M. L., Alvarez, Y., Miret, M., Hesse, U., Gardarsdottir, H., Souverein, P., Slattery, J., Schneider, C., Rottenkolber, M., Schmiedl, S., Gil, M., De Groot, M. C. H., Bate, A., Ruigómez, A., García, L. A., Johanson, S., ... De Abajo, F. J. (2013). Trends in incidence rates (IR) of hip/femur fractures in five european countries: A comparison using electronic health care records (E-HCR). Pharmacoepidemiology and Drug Safety, 22(s1), 408-409. Article 811. https://doi.org/10.1002/pds.3512

2012

Other output

Thengilsdottir, G., Gardarsdottir, H., Almarsdottir, A. B., McClure, C. B., & Heerdink, E. R. (2012). Does Lifting an Administrative Restriction on Antidepressant Drug Prescribing Influence Treatment Patterns? Pharmacoepidemiology and Drug Safety, 21, 436-437.
Abdullah-Koolmees, H., Gardarsdottir, H., Stoker, L. S., Vuyk, J., Egberts, T. C. G., & Heerdink, E. R. (2012). Prevalence of Medication Use for Somatic Disease in Hospitalized Psychiatric Patients. Pharmacoepidemiology and Drug Safety, 21, 435-436.
Abdullah-Koolmees, H., Gerbranda, T., Deneer, V. H. M., Tjoeng, M. M., De Ridder, A. J. M., Gardarsdottir, H., & Heerdink, E. R. (2012). Discontinuation of Anticoagulant Care during Admission in a Psychiatric Hospital. Pharmacoepidemiology and Drug Safety, 21, 287-287.
Gardarsdottir, H., Sauer, B. C., Liang, H., Ryan, P., Klungel, O., & Reynolds, R. (2012). Transparent, reproducible and reusable research in pharmacoepidemiology. Pharmacoepidemiology and Drug Safety, 21(S3), 197. Article 416. https://doi.org/10.1002/pds.3324
Abbing-Karahagopian, V., Gardarsdottir, H., Souverein, P. C., Klungel, O. H., Leufkens, B. G. M., Egberts, T. C. G., & De Bruin, M. L. (2012). Timing of concomitant drug use in pharmacoepidemiological studies. Pharmacoepidemiology and Drug Safety, 21(S3), 423. Article 914. https://doi.org/10.1002/pds.3324

2011

Other output

Curkendall, S., Liang, H., Gardarsdottir, H., & Misra, A. (2011). Coding Algorithms for Defining Study Population in Database Studies; a Literature Review. Pharmacoepidemiology and Drug Safety, 20, S163-S163.

2010

Scholarly publications

Gardarsdottir, H., Egberts, T. C. G., & Heerdink, E. R. (2010). The association between patient-reported drug taking and gaps and overlaps in antidepressant drug dispensing. Annals of Pharmacotherapy, 44(11), 1755-1761. https://doi.org/10.1345/aph.1P162
Gardarsdottir, H., Souverein, P. C., Egberts, T. C. G., & Heerdink, E. R. (2010). Construction of drug treatment episodes from drug-dispensing histories is influenced by the gap length. Journal of Clinical Epidemiology, 63(4), 422-7. https://doi.org/10.1016/j.jclinepi.2009.07.001
Gardarsdottir, H., Egberts, A. C. G., & Heerdink, E. R. (2010). Transitions from General Practitioner to Psychiatrist Care (or vice versa) during a first antidepressant treatment episode. Pharmacopsychiatry, 43(5), 179-183. https://doi.org/10.1055/s-0030-1249096
Gardarsdottir, H., Egberts, T. C. G., van Dijk, L., & Heerdink, E. R. (2010). Seasonal patterns of initiating antidepressant therapy in general practice in the Netherlands during 2002-2007. Journal of Affective Disorders, 122(3), 208-12. https://doi.org/10.1016/j.jad.2009.06.033

Other output

Gardarsdottir, H., Egberts, A. C. G., & Heerdink, E. R. (2010). Transitions from General Practitioner to Psychiatrist Care (Or Vice Versa) During a First Antidepressant Treatment Episode. S272, 643. Abstract from Abstracts of the 26th International Conference on Pharmacoepidemiology & Therapeutic Risk Management, 19-22 August 2010, Brighton, UK.

2009

Scholarly publications

Gardarsdottir, H., Egberts, T. C., Stolker, J. J., & Heerdink, E. R. (2009). Gardarsdottir et al. Respond to "Assessing Treatment Effects With Observational Analyses". American Journal of Epidemiology, 170(3), 288-288. https://doi.org/10.1093/aje/kwp138
van Geffen, E. C. G., Gardarsdottir, H., van Hulten, R., van Dijk, L., Egberts, A. C. G., & Heerdink, E. R. (2009). Initiation of antidepressant therapy: do patients follow the GP's prescription? British Journal of General Practice, 59(559), 81-87. https://doi.org/10.3399/bjgp09X395067
Gardarsdottir, H., van Geffen, E. C. G., Stolker, J. J., Egberts, T. C. G., & Heerdink, E. R. (2009). Does the Length of the First Antidepressant Treatment Episode Influence Risk and Time to a Second Episode? Journal of Clinical Psychopharmacology, 29(1), 69-72. https://doi.org/10.1097/JCP.0b013e31819302b1
Gardarsdottir, H., Egberts, T. C., Stolker, J. J., & Heerdink, E. R. (2009). Duration of Antidepressant Drug Treatment and Its Influence on Risk of Relapse/Recurrence: Immortal and Neglected Time Bias. American Journal of Epidemiology, 170(3), 280-285. https://doi.org/10.1093/aje/kwp142
Gardarsdottir, H. (2009). Drug treatment episodes in pharmacoepidemiology - antidepressant use as a model. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/36021/gardarsdottir.pdf?sequence=1
Gardarsdottir, H., Egberts, A. C. G., van Dijk, L., Sturkenboom, M. C. J. M., & Heerdink, E. R. (2009). An algorithm to identify antidepressant users with a diagnosis of depression from prescription data. Pharmacoepidemiology and Drug Safety, 18(1), 7-15. https://doi.org/10.1002/pds.1677

Other output

Gardarsdottir, H., Heerdink, E. R., & Egberts, A. C. G. (2009). Constructing Drug Treatment Episodes from Individual Dispensed Prescriptions: The Influence of the Gap-Length. Pharmacoepidemiology and Drug Safety, 18, S63.

2008

Other output

Gardarsdottir, H., Egberts, T. C. G., & Heerdink, E. R. (2008). Neglected and immortal time bias in observational studies: Antidepressant drug use and risk of relapse/recurrence. Pharmacoepidemiology and Drug Safety, 17, S135-S136.
Gardarsdottir, H., Egberts, T. C. G., van Dijk, L., Sturkenboom, M., & Heerdink, E. R. (2008). An algorithm to identify antidepressant users with a diagnosis of depression from prescription data. Pharmacoepidemiology and Drug Safety, 17, S1-S1.
Gardarsdottir, H., Egberts, A. C. G., van Dijk, C. E. M. J., Sturkenboom, M. C. J. M., & Heerdink, E. R. (2008). An Algorithm To Identify Antidepressant Users with a Diagnosis of Depression from Prescription Data. S1. Abstract from 24th International Conference on Pharmacoepidemiology & Therapeutic Risk Management.

2007

Scholarly publications

Bosman, A. A. P., Gardarsdóttir, H., Härmark, L., Lourenço, L. M., Wuliji, T., Bates, I., & Carter, S. (2007). Academic mobility in pharmacy faculty: An exploratory study. Pharmacy Education, 7(2), 177-181. https://doi.org/10.1080/15602210701256757
Gardarsdottir, H., Heerdink, E. R., van Dijk, L., & Egberts, A. C. G. (2007). Indications for antidepressant drug prescribing in general practice in the Netherlands. Journal of Affective Disorders, 98(1-2), 109-115. https://doi.org/10.1016/j.jad.2006.07.003

2006

Scholarly publications

Gardarsdottir, H., Heerdink, ER., & Egberts, ACG. (2006). Potential bias in pharmacoepidemiological studies due to the length of the drug free period: a study on antidepressant drug use in adults in the Netherlands. Pharmacoepidemiology and Drug Safety, 15(5), 338-343. https://doi.org/10.1002/pds.1223
Gardarsdottir, H., Heerdink, E. R., & Egberts, A. C. G. (2006). Potential bias in pharmacoepidemiological studies due to the length of the drug free period: a study on antidepressant drug use in adults in the Netherlands. Pharmacoepidemiology and Drug Safety, 15, 338-343.
https://dspace.library.uu.nl/bitstream/handle/1874/19727/egberts_06_Potential_bias.pdf?sequence=1

Other output

Gardarsdottir, H., Heerdink, E. R., van Dijk, L., & Egberts, A. C. G. (2006). Indications for antidepressant drug prescribing in general practice in the Netherlands. Pharmacoepidemiology and Drug Safety, 15, S163-S164.
Gardarsdottir, H., Heerdink, E. R., van Dijk, L., & Egberts, A. C. G. (2006). Indications for Antidepressant Drug Prescribing in General Practice in the Netherlands. S163. Abstract from Unknown event, Asilomar, USA.

2005

Other output

Gardarsdottir, H., Heerdink, E. R., & Egberts, A. C. G. (2005). Potential Bias in Pharmacoepidemiological Studies Due to the Length of the Drug Free Period: A Study on Antidepressant Drug Use in Adults in the Netherlands. S202. Abstract from Unknown event, Asilomar, USA.