Publications
2024
Scholarly publications
Segeren, H. A., Wierenga, K. A., Riemers, F. M., Liere, E. A. V., & Westendorp, B. (2024, Mar 28). Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance. https://doi.org/10.1101/2024.03.26.585806
2022
Scholarly publications
Wierenga, K. A., Riemers, F. M., Westendorp, B., Harkema, J. R., & Pestka, J. J. (2022). Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage. Frontiers in Immunology, 13, Article 993614. https://doi.org/10.3389/fimmu.2022.993614
Segeren, H. A., van Liere, E. A., Riemers, F. M., de Bruin, A., & Westendorp, B. (2022). Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53. Oncogene, 41(19), 2719-2733. https://doi.org/10.1038/s41388-022-02291-0
Warmink, K., Siebelt, M., Low, P. S., Riemers, F. M., Wang, B., Plomp, S. G. M., Tryfonidou, M. A., van Weeren, P. R., Weinans, H., & Korthagen, N. M. (2022). Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids. Cartilage, 13(1), Article 19476035221081469. https://doi.org/10.1177/19476035221081469
2021
Scholarly publications
Bach, F. C., Poramba-Liyanage, D. W., Riemers, F. M., Guicheux, J., Camus, A., Iatridis, J. C., Chan, D., Ito, K., Le Maitre, C. L., & Tryfonidou, M. A. (2021). Notochordal Cell-Based Treatment Strategies and Their Potential in Intervertebral Disc Regeneration. Frontiers in Cell and Developmental Biology, 9, 1-23. Article 780749. https://doi.org/10.3389/fcell.2021.780749
Sanders, K., Veldhuizen, A., Kooistra, H. S., Slob, A., Timmermans-Sprang, E. P. M., Riemers, F. M., Daminet, S., Fracassi, F., van Nimwegen, S. A., Meij, B. P., & Galac, S. (2021). Circulating MicroRNAs as Non-invasive Biomarkers for Canine Cushing's Syndrome. Frontiers in Veterinary Science, 8, 1-12. Article 760487. https://doi.org/10.3389/fvets.2021.760487
Teunissen, M., Miranda Bedate, A., Coeleveld, K., Riemers, F. M., Meij, B. P., Lafeber, F. P. J. G., Tryfonidou, M. A., & Mastbergen, S. C. (2021). Enhanced Extracellular Matrix Breakdown Characterizes the Early Distraction Phase of Canine Knee Joint Distraction. Cartilage, 13(2_suppl), 1654S-1664S. https://doi.org/10.1177/19476035211014595
Teunissen, M., Verseijden, F., Riemers, F. M., van Osch, G. J. V. M., & Tryfonidou, M. A. (2021). The lower in vitro chondrogenic potential of canine adipose tissue-derived mesenchymal stromal cells (MSC) compared to bone marrow-derived MSC is not improved by BMP-2 or BMP-6. Veterinary Journal, 269, 1-8. Article 105605. https://doi.org/10.1016/j.tvjl.2020.105605
2020
Scholarly publications
Segeren, H. A., van Rijnberk, L., Moreno, E., Riemers, F., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell Cycle Exit after DNA Damage. SSRN. https://doi.org/10.2139/ssrn.3570558
Segeren, H. A., van Rijnberk, L. M., Moreno, E., Riemers, F. M., van Liere, E. A., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage. Cell Reports, 33(9), Article 108449. https://doi.org/10.1016/j.celrep.2020.108449
2019
Scholarly publications
Bach, F. C., de Rooij, K. M., Riemers, F. M., Snuggs, J. W., de Jong, W. A. M., Zhang, Y., Creemers, L. B., Chan, D., Le Maitre, C., & Tryfonidou, M. A. (2019). Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification. Spine, 2(4), Article e1071. https://doi.org/10.1002/jsp2.1071
Tellegen, A. R., Dessing, A. J., Houben, K., Riemers, F. M., Creemers, L. B., Mastbergen, S. C., Meij, B. P., Miranda-Bedate, A., & Tryfonidou, M. A. (2019). Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter. Journal of Orthopaedic Research, 37(12), 2550-2560. https://doi.org/10.1002/jor.24432
Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A., & Creemers, L. B. (2019). Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis. Journal of Controlled Release, 294, 247-258. https://doi.org/10.1016/j.jconrel.2018.12.030
2018
Scholarly publications
Teunissen, M., Riemers, F. M., van Leenen, D., Koerkamp, M. J. G., Meij, B. P., Miranda-Bedate, A., & Tryfonidou, M. A. (2018). Investigating intraspecies differences of the growth plate of small and large breed dogs in order to gain new insights in cartilage biology. In Abstracts from the 2018 OARSI World Congress on Osteoarthritis (Vol. 26, pp. S106). (Osteoarthritis and Cartilage). https://doi.org/10.1016/j.joca.2018.02.232
Vastenhout, N., van Rijn, S. J., Riemers, F. M., Tryfonidou, M. A., Meij, B. P., & Penning, L. C. (2018). The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas. Veterinary Journal, 240, 19-21. https://doi.org/10.1016/j.tvjl.2018.08.012
Teunissen, M., M Riemers, F., van Leenen, D., J A Groot Koerkamp, M., P Meij, B., Alblas, J., C Penning, L., Miranda-Bedate, A., & A Tryfonidou, M. (2018). Growth Plate Expression profiling: Large and Small Breed Dogs Provide New Insights in Endochondral Bone Formation. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.23647
2017
Scholarly publications
Bach, F., Miranda-Bedate, A., van Heel, F., Riemers, F., Muller, M., Creemers, L., Ito, K., Benz, K., Meij, B., & Tryfonidou, M. (2017). Bone morphogenetic protein-2, but not mesenchymal stromal cells, exert regenerative effects on canine and human nucleus pulposus cells. Tissue Engineering. Part A, 23(5-6), 233-242. https://doi.org/10.1089/ten.TEA.2016.0251
https://dspace.library.uu.nl/bitstream/handle/1874/349093/Bone.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/349093/Bone.pdf?sequence=1
2016
Scholarly publications
Bach, F. C., de Vries, S. A., Riemers, F. M., Boere, J., van Heel, F. W., van Doeselaar, M., Goerdaya, S. S., Nikkels, P. G., Benz, K., Creemers, L. B., Maarten Altelaar, A. F., Meij, B. P., Ito, K., & Tryfonidou, M. A. (2016). Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration. European Cells & Materials [E], 32, 163-80. https://doi.org/10.22203/eCM.v0 32 a11
Other output
de Visser, H. M., Mastbergen, S. C., Plomp, S. G., Riemers, F. M., Korthagen, N. M., Tryfonidou, M. A., Lafeber, F. P., & Weinans, H. (2016). A novel method of RNA isolation and gene expression profiling of articular cartilage in rats by cryotome sectioning. S158-S159. https://doi.org/10.1016/j.joca.2016.01.313
2015
Scholarly publications
Stassen, Q. E. M., Riemers, F. M., Reijmerink, H., Leegwater, P. A. J., & Penning, L. C. (2015). Reference genes for reverse transcription quantitative PCR in canine brain tissue. BMC Research Notes, 8(1), Article 761. https://doi.org/10.1186/s13104-015-1628-4
Willems, N., Yang, H.-Y., Langelaan, M. L. P., Tellegen, A. R., Grinwis, G. C. M., Kranenburg, H.-J. C., Riemers, F. M., Plomp, S. G. M., Craenmehr, E. G. M., Dhert, W. J. A., Papen-Botterhuis, N. E., Meij, B. P., Creemers, L. B., & Tryfonidou, M. (2015). Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model. Arthritis Research & Therapy, 17(1), 214. https://doi.org/10.1186/s13075-015-0727-x
Brinkhof, B., van Tol, H. T. A., Groot Koerkamp, M. J. A., Riemers, F. M., IJzer, S. G., Mashayekhi, K., Haagsman, H. P., & Roelen, B. A. J. (2015). A mRNA landscape of bovine embryos after standard and MAPK-inhibited culture conditions: a comparative analysis. BMC Genomics, 16, 277. https://doi.org/10.1186/s12864-015-1448-x
Arkesteijn, I. T., Smolders, L. A., Spillekom, S., Riemers, F. M., Potier, E., Meij, B. P., Ito, K., & Tryfonidou, M. A. (2015). Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration. Arthritis Research & Therapy, 17(1), Article 60. https://doi.org/10.1186/s13075-015-0569-6
2014
Scholarly publications
Bach, F. C., Rutten, K., Hendriks, K., Riemers, F. M., Cornelissen, P., de Bruin, A., Arkesteijn, G. J., Wubbolts, R., Horton, W. A., Penning, L. C., & Tryfonidou, M. A. (2014). The paracrine feedback loop between vitamin Dā (1,25(OH)āDā) and PTHrP in prehypertrophic chondrocytes. Journal of Cellular Physiology, 229(12), 1999-2014. https://doi.org/10.1002/jcp.24658
van Rijn, S. J., Riemers, F. M., van den Heuvel, D., Wolfswinkel, J., Hofland, L., Meij, B. P., & Penning, L. C. (2014). Expression stability of reference genes for quantitative RT-PCR of healthy and diseased pituitary tissue samples varies between humans, mice, and dogs. Molecular Neurobiology, 49(2), 893-899. https://doi.org/10.1007/s12035-013-8567-7
2013
Scholarly publications
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Houweling, M., Groot Koerkamp, M. J. A., van Leenen, D., Holstege, F. C. P., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research & Therapy, 15(1), R23. https://doi.org/10.1186/ar4157
2012
Scholarly publications
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Identification of a novel biomolecular target for regeneration of the degenerated canine intervertebral disc. In Proceedings 25th annual symposium of the European Society of Veterinary Neurology (ECVN) and European College of Veterinary Neurology (ESVN) (pp. 14-14)
Smolders, L. A., Onis, D., Riemers, F. M., Penning, L. C., Bergknut, N., Kranenburg, H. C., Hazewinkel, H. A. W., Grinwis, G. C. M., Groot Koerkamp, M., Meij, B. P., & Tryfonidou, M. A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration. In Abstract Book Spineweek 2012 (pp. 256)
van Rijn, S. J., Gremeaux, L., Riemers, F. M., Brinkhof, B., Vankelecom, H., Penning, L. C., & Meij, B. P. (2012). Identification and characterisation of side population cells in the canine pituitary gland. Veterinary Journal, 192(3), 476-482. https://doi.org/10.1016/j.tvjl.2011.06.030
Corbee, R. J., Booij-Vrieling, H. E., van de Lest, C. H. A., Penning, L. C., Tryfonidou, M. A., Riemers, F. M., & Hazewinkel, H. A. W. (2012). Inflammation and wound healing in cats with chronic gingivitis/stomatitis after extraction of all premolars and molars were not affected by feeding of two diets with different omega-6/omega-3 polyunsaturated fatty acid ratios. Journal of Animal Physiology and Animal Nutrition, 96(2012), 679-688. https://doi.org/10.1111/j.1439-0396.2011.01195.x
Smolders, L. A., Meij, B. P., Riemers, F. M., Licht, R., Wubbolts, R. W., van den Heuvel, D. J., Grinwis, G. C. M., Vernooij, H., Hazewinkel, H. A. W., Penning, L. C., & Tryfonidou, M. A. (2012). Canonical Wnt Signaling in the Notochordal Cell is Upregulated in Early Intervertebral Disk Degeneration. Journal of Orthopaedic Research, 30(6), 950-957. https://doi.org/10.1002/jor.22000
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration suggests a crucial role of caveolin-1 in notochordal cell preservation. In Proceedings European Veterinary Conference Voorjaarsdagen 2012 (pp. 236-237)
2011
Scholarly publications
Schlotter, Y. M., Rutten, V. P. M. G., Riemers, F. M., Knol, E. F., & Willemse, T. (2011). Lesional skin in atopic dogs shows a mixed Type-1 and Type-2 immune responsiveness. Veterinary Immunology and Immunopathology, 143(1-2), 20-26.
Tryfonidou, M. A., Lunstrum, G. P., Hendriks, K., Riemers, F. M., Wubbolts, R., Hazewinkel, H. A. W., Degnin, C. R., & Horton, W. A. (2011). Novel Type II Collagen Reporter Mice: New Tool for Assessing Collagen 2 alpha 1 Expression In Vivo and In Vitro. Developmental Dynamics, 240(3), 663-673. https://doi.org/10.1002/dvdy.22569
2010
Scholarly publications
Vrieling, H. E., Ferbus, D., Tryfonidou, M. A., Riemers, F. M., Penning, L. C., Berdal, A., Everts, V., & Hazewinkel, H. A. W. (2010). Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats. European Journal of Oral Sciences, 118(1), 39-46. https://doi.org/10.1111/j.1600-0722.2009.00707.x
https://dspace.library.uu.nl/bitstream/handle/1874/204556/j.1600-0722.2009.00707.x.pdf?sequence=3
https://dspace.library.uu.nl/bitstream/handle/1874/204556/j.1600-0722.2009.00707.x.pdf?sequence=3
Tryfonidou, M. A., Hazewinkel, H. A. W., Riemers, F. M., Brinkhof, B., Penning, L. C., & Karperien, M. (2010). Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators. American Journal of Physiology-Endocrinology and Metabolism, 299(6), 1044-1052. https://doi.org/10.1152/ajpendo.00170.2010
Schlotter, Y. M., Riemers, F. M., Rutten, V. P. M. G., Knol, E. F., & Willemse, T. (2010). Enzymes involved in the conversion of arachidonic acid to eicosanoids in the skin of atopic dogs. Experimental Dermatology, 19, e317-e319. https://doi.org/10.1111/j.1600-0625.2009.01037.x
Other output
van Rijn, S. J., Gremeaux, L., Riemers, F. M., Penning, L. C., Meij, B. P., & Vankelecom, H. (Accepted/In press). Identification and characterization of side population cells in the canine pituitary gland. 270-270. Abstract from European Veterinary Conference Voorjaarsdagen, Amsterdam.
2009
Scholarly publications
Vrieling, H. E., Tryfonidou, M. A., Riemers, F. M., Penning, L. C., & Hazewinkel, H. A. W. (2009). Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats. Veterinary Immunology and Immunopathology, 132, 160-166.
Schlotter, Y. M., Rutten, V. P. M. G., Riemers, F. M., Davenport, G., Knol, E. F., & Willemse, T. (2009). Altered expression of fatty acid desaturases in the skin of dogs with atopic dermatitis. Journal of Dermatological Science, 54(1), 49-52.