Publications
2025
Scholarly publications
Ijaz, A., Putman, M., Broere, F., Rutten, V. P. M. G., Jansen, C. A., & Veldhuizen, E. J. A. (2025). Activation of chicken macrophages by isomalto/malto-polysaccharide (IMMP) is facilitated by toll-like receptor 4 (TLR4). Poultry Science, 104(11), Article 105690. Advance online publication. [DOI] [Portal]
Karagianni, A. E., Benedictus, L., Steinbach, S., Broere, F., & van der Heijden, E. M. D. L. (2025). Characterization of the global bovine microRNAome of peripheral blood mononuclear cells isolated from Mycobacterium bovis exposed cattle. Tuberculosis (Edinburgh, Scotland), 153, Article 102639. [DOI] [Portal]
2024
Scholarly publications
Stoppelenburg, A. J., Schreibelt, G., Koeneman, B., Welsing, P. M. J., Breman, E.-J., Lammers, L., de Goede, A., Duiveman-de Boer, T., van Eden, W., Leufkens, P., de Vries, I. J. M., Broere, F., & van Laar, J. M. (2024). Design of TOLERANT: phase I/II safety assessment of intranodal administration of HSP70/mB29a self-peptide antigen-loaded autologous tolerogenic dendritic cells in patients with rheumatoid arthritis. BMJ Open, 14(9), Article e078231. [DOI] [Portal]
de Jong, M. K., van Eijk, D., Broere, F., & Piek, C. J. (2024). Owners' experiences of administering meglumine antimoniate injections to dogs with leishmaniosis: An online questionnaire study. The Veterinary record, 194(11), Article e4089. [DOI] [Repository]
Benne, N., Braake, D. T., Porenta, D., Lau, C. Y. J., Mastrobattista, E., & Broere, F. (2024). Autoantigen-dexamethasone Conjugate-Loaded Liposomes Halt Arthritis Development in Mice. Advanced healthcare materials, 13(12), Article 2304238. [DOI] [Repository]
2023
Scholarly publications
Lyu, Q., Veldhuizen, E. J. A., Ludwig, I. S., Rutten, V. P. M. G., van Eden, W., Sijts, A. J. A. M., & Broere, F. (2023). Characterization of polarization states of canine monocyte derived macrophages. PLoS One, 18(11), Article e0292757. [DOI] [Repository]
Javed, A., Balhuizen, M. D., Pannekoek, A., Bikker, F. J., Heesterbeek, D. A. C., Haagsman, H. P., Broere, F., Weingarth, M., & Veldhuizen, E. J. A. (2023). Effects of Escherichia coli LPS Structure on Antibacterial and Anti-Endotoxin Activities of Host Defense Peptides. Pharmaceuticals (Basel, Switzerland), 16(10), Article 1485. [DOI] [Repository]
Ijaz, A., Broere, F., Rutten, V. P. M. G., Jansen, C. A., & Veldhuizen, E. J. A. (2023). Perforin and granzyme A release as novel tool to measure NK cell activation in chickens. Developmental and Comparative Immunology, 149, Article 105047. [DOI] [Repository]
Vreman, S., van der Heijden, E. M. D. L., Ravesloot, L., Ludwig, I. S., van den Brand, J. M. A., Harders, F., Kampfraath, A. A., Egberink, H. F., Gonzales, J. L., Oreshkova, N., Broere, F., van der Poel, W. H. M., & Gerhards, N. M. (2023). Immune Responses and Pathogenesis following Experimental SARS-CoV-2 Infection in Domestic Cats. Viruses, 15(5), 1-18. Article 1052. [DOI] [Repository]
de Jong, M. K., Rappoldt, A., Broere, F., & Piek, C. J. (2023). Survival time and prognostic factors in canine leishmaniosis in a non-endemic country treated with a two-phase protocol including initial allopurinol monotherapy. Parasites & Vectors, 16(1), 1-9. Article 163. [DOI] [Repository]
Javed, A., Slingerland, C. J., Wood, T. M., Martin, N. I., Broere, F., Weingarth, M. H., & Veldhuizen, E. J. A. (2023). Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS Infectious Diseases , 9(3), 518-526. [DOI] [Repository]
Novak, A., Hindriks, E., Hoek, A., Veraart, C., Broens, E. M., Ludwig, I., Rutten, V., Sloots, A., & Broere, F. (2023). Cellular and humoral immune responsiveness to inactivated Leptospira interrogans in dogs vaccinated with a tetravalent Leptospira vaccine. Vaccine, 41(1), 119-129. [DOI] [Repository]
Teunissen, M., Meij, B. P., Snel, L., Coeleveld, K., Popov-Celeketic, J., Ludwig, I. S., Broere, F., Lafeber, F. P. J. G., Tryfonidou, M. A., & Mastbergen, S. C. (2023). The catabolic-to-anabolic shift seen in the canine osteoarthritic cartilage treated with knee joint distraction occurs after the distraction period. Journal of Orthopaedic Translation, 38, 44-55. [DOI] [Repository]
2022
Scholarly publications
Vandebriel, R. J., Stalpers, C. A. L., Vermeulen, J. P., Remkes, M., Schmelter, M., Broere, F., & Hoefnagel, M. H. N. (2022). Development of a cell line-based in vitro assay for assessment of Diphtheria, Tetanus and acellular Pertussis (DTaP)-induced inflammasome activation. Vaccine, 40(38), 5601-5607. [DOI] [Repository]
Teunissen, M., Mastbergen, S. C., Spoelman, D., Lafeber, F., Ludwig, I., Broere, F., Tryfonidou, M., & Meij, B. (2022). Knee Joint Distraction in a Dog as Treatment for Severe Osteoarthritis. VCOT Open, 5(1), e11-e17. [DOI] [Repository]
Novak, A., Pennings, J. L., van der Maas, L., Meiring, H. D., Ludwig, I., Rutten, V. P. M. G., Verkoeijen, S., Broere, F., & Sloots, A. (2022). Transcriptome and proteome analysis of innate immune responses to inactivated Leptospira and bivalent Leptospira vaccines in canine 030-D cells. Scientific Reports, 12(1), 1-14. Article 13418. [DOI] [Repository]
van Os, N., Javed, A., Broere, F., van Dijk, A., Balhuizen, M. D., van Eijk, M., Rooijakkers, S. H. M., Bardoel, B. W., Heesterbeek, D. A. C., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Novel insights in antimicrobial and immunomodulatory mechanisms of action of PepBiotics CR-163 and CR-172. Journal of Global Antimicrobial Resistance, 30, 406-413. [DOI] [Repository]
Lau, C. Y. J., Benne, N., Lou, B., Zharkova, O., Ting, H. J., Ter Braake, D., van Kronenburg, N., Fens, M. H., Broere, F., Hennink, W. E., Wang, J.-W., & Mastrobattista, E. (2022). Modulating albumin-mediated transport of peptide-drug conjugates for antigen-specific Treg induction. Journal of controlled release : official journal of the Controlled Release Society, 348, 938-950. [DOI] [Repository]
Fennis, E. E. M., van Damme, C. M. M., Schlotter, Y. M., Sinke, J. D., Leistra, M. H. G., Bartels, R. T., & Broere, F. (2022). Efficacy of subcutaneous allergen immunotherapy in atopic dogs: A retrospective study of 664 cases. Veterinary Dermatology, 33(4), 321-e75. [DOI] [Repository]
Novak, A., Pupo, E., Van't Veld, E., Rutten, V. P. M. G., Broere, F., & Sloots, A. (2022). Activation of Canine, Mouse and Human TLR2 and TLR4 by Inactivated Leptospira Vaccine Strains. Frontiers in Immunology, 13, 1-16. Article 823058. [DOI] [Repository]
Benne, N., ter Braake, D., Stoppelenburg, A., & Broere, F. (2022). Nanoparticles for Inducing Antigen-Specific T Cell Tolerance in Autoimmune Diseases. Frontiers in Immunology, 13, 1-15. Article 864403. [DOI] [Repository]
Lau, C. Y. J., Benne, N., Lou, B., Braake, D. T., Bosman, E., van Kronenburg, N., Fens, M., Broere, F., Hennink, W. E., & Mastrobattista, E. (2022). Tuning surface charges of peptide nanofibers for induction of antigen-specific immune tolerance: an introductory study. Journal of Pharmaceutical Sciences, 111(4), 1004-1011. [DOI] [Repository]
2021
Scholarly publications
Ter Braake, D., Benne, N., Lau, C. Y. J., Mastrobattista, E., & Broere, F. (2021). Retinoic Acid-Containing Liposomes for the Induction of Antigen-Specific Regulatory T Cells as a Treatment for Autoimmune Diseases. Pharmaceutics, 13(11), 1-17. Article 1949. [DOI] [Repository]
Ijaz, A., Veldhuizen, E. J. A., Broere, F., Rutten, V. P. M. G., & Jansen, C. A. (2021). The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens. Pathogens, 10(11), 1-20. Article 1512. [DOI] [Repository]
2020
Scholarly publications
Lyu, Q., Wawrzyniuk, M., Rutten, V. P. M. G., van Eden, W., Sijts, A. J. A. M., & Broere, F. (2020). Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line. International Journal of Molecular Sciences, 21(18), Article 6464. [DOI] [Repository]
Lyu, Q., Ludwig, I. S., Kooten, P. J. S., Sijts, A. J. A. M., Rutten, V. P. M. G., van Eden, W., & Broere, F. (2020). Leucinostatin acts as a co-inducer for heat shock protein 70 in cultured canine retinal pigment epithelial cells. Cell Stress & Chaperones, 25, 235-243. [DOI] [Repository]
2019
Scholarly publications
Spiering, R., Jansen, M. A. A., Wood, M. J., Fath, A. A., Eltherington, O., Anderson, A. E., Pratt, A. G., Van Eden, W., Isaacs, J. D., Broere, F., & Hilkens, C. M. U. (2019). Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis. Journal of Translational Medicine, 17(1), Article 375. [DOI] [Repository]
Jansen, M. A. A., Spiering, R., Ludwig, I. S., van Eden, W., Hilkens, C. M. U., & Broere, F. (2019). Matured Tolerogenic Dendritic Cells Effectively Inhibit Autoantigen Specific CD4+ T Cells in a Murine Arthritis Model. Frontiers in Immunology, 10, Article 2068. [DOI] [Repository]
Jansen, M. A. A., Klausen, L. H., Thanki, K., Lyngsø, J., Skov Pedersen, J., Franzyk, H., Nielsen, H. M., van Eden, W., Dong, M., Broere, F., Foged, C., & Zeng, X. (2019). Lipidoid-polymer hybrid nanoparticles loaded with TNF siRNA suppress inflammation after intra-articular administration in a murine experimental arthritis model. European Journal of Pharmaceutics and Biopharmaceutics, 142, 38-48. [DOI] [Repository]
van Eden, W., Jansen, M. A. A., Ludwig, I. S., Leufkens, P., van der Goes, M. C., van Laar, J. M., & Broere, F. (2019). Heat Shock Proteins Can Be Surrogate Autoantigens for Induction of Antigen Specific Therapeutic Tolerance in Rheumatoid Arthritis. Frontiers in Immunology, 10, Article 279. [DOI] [Repository]
Benedictus, L., Ravesloot, L., Poppe, K., Daemen, I., Boerhout, E., van Strijp, J., Broere, F., Rutten, V., Koets, A., & Eisenberg, S. (2019). Immunization of young heifers with staphylococcal immune evasion proteins before natural exposure to Staphylococcus aureus induces a humoral immune response in serum and milk. BMC Veterinary Research, 15, Article 15. [DOI] [Repository]
Chermprapai, S., Ederveen, T. H. A., Broere, F., Broens, E. M., Schlotter, Y. M., van Schalkwijk, S., Boekhorst, J., van Hijum, S. A. F. T., & Rutten, V. P. M. G. (2019). The bacterial and fungal microbiome of the skin of healthy dogs and dogs with atopic dermatitis and the impact of topical antimicrobial therapy, an exploratory study. Veterinary Microbiology, 229, 90-99. [DOI] [Repository]
2018
Scholarly publications
van Eden, W., Broere, F., & van der Zee, R. (2018). HSP70 Is a Major Contributor to the MHCII Ligandome and Inducer of Regulatory T Cells. In A. A. A. Asea, & P. Kaur (Eds.), HSP70 in Human Diseases and Disorders (pp. 163-171). (Heat shock proteins; Vol. 14). Springer. [DOI] [Repository]
Chermprapai, S., Broere, F., Schlotter, Y. M., Veldhuizen, E. J. A., & Rutten, V. P. M. G. (2018). A canine keratinocyte cell line expresses antimicrobial peptide and cytokine genes upon stimulation with bacteria, microbial ligands and recombinant cytokines. Veterinary Immunology and Immunopathology, 206, 35-40. [DOI] [Repository]
Ludwig, I. S., Broere, F., Manurung, S., Lambers, T. T., van der Zee, R., & van Eden, W. (2018). Lactobacillus rhamnosus GG-derived soluble mediators modulate adaptive immune cells. Frontiers in Immunology, 9, 1-6. Article 1546. [DOI] [Repository]
de Groot, A. M., Thanki, K., Gangloff, M., Falkenberg, E., Zeng, X., van Bijnen, D. C. J., van Eden, W., Franzyk, H., Nielsen, H. M., Broere, F., Gay, N. J., Foged, C., & Sijts, A. J. A. M. (2018). Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design. Molecular Therapy - Nucleic Acids, 11, 159-169. [DOI] [Repository]
van Aalst, S., Jansen, M. A. A., Ludwig, I. S., van der Zee, R., van Eden, W., & Broere, F. (2018). Routing dependent immune responses after experimental R848-adjuvated vaccination. Vaccine, 36(11), 1405-1413. [DOI] [Repository]
Chermprapai, S., Broere, F., Gooris, G., Schlotter, Y. M., Rutten, V. P. M. G., & Bouwstra, J. A. (2018). Altered lipid properties of the stratum corneum in Canine Atopic Dermatitis. Biochimica et Biophysica Acta, 1860(2), 526-533. [DOI] [Repository]
de Groot, A. M., Du, G., Mönkäre, J., Platteel, A. C. M., Broere, F., Bouwstra, J. A., & Sijts, A. J. A. M. (2018). Hollow microneedle-mediated intradermal delivery of model vaccine antigen-loaded PLGA nanoparticles elicits protective T cell-mediated immunity to an intracellular bacterium. Journal of Controlled Release, 266, 27-35. [DOI] [Repository]
Jansen, M. A. A., Spiering, R., Broere, F., van Laar, J. M., Isaacs, J. D., van Eden, W., & Hilkens, C. M. U. (2018). Targeting of tolerogenic dendritic cells towards heat shock proteins: a novel therapeutic strategy for autoimmune diseases? Immunology, 153(1), 51-59. [DOI] [Repository]
2017
Scholarly publications
van Eden, W., Jansen, M. A. A., de Wolf, A. C. M., Ludwig, I. S., Leufkens, P., & Broere, F. (2017). The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins. Frontiers in Immunology, 8, Article 1690. [DOI] [Repository]
van Eden, W., Jansen, M. A. A., Ludwig, I., van Kooten, P., van der Zee, R., & Broere, F. (2017). The Enigma of Heat Shock Proteins in Immune Tolerance. Frontiers in Immunology, 8, Article 1599. [DOI] [Repository]
Betancourt, A. B., Lyu, Q., Broere, F., Sijts, A., Rutten, V. P. M. G., & Eden, W. V. (2017). T Cell-Mediated Chronic Inflammatory Diseases Are Candidates for Therapeutic Tolerance Induction with Heat Shock Proteins. Frontiers in Immunology, 8(October), 1-10. [DOI] [Repository]
de Wolf, A. C. M. T., van Aalst, S., Ludwig, I. S., Bodinham, C. L., Lewis, D. J., van der Zee, R., van Eden, W., & Broere, F. (2017). Regulatory T cell frequencies and phenotypes following anti-viral vaccination. PLoS One, 12(6), Article e0179942. [DOI] [Repository]
van Aalst, S., Ludwig, I. S., van Kooten, P. J. S., van der Zee, R., van Eden, W., & Broere, F. (2017). Dynamics of APC recruitment at the site of injection following injection of vaccine adjuvants. Vaccine, 35(12), 1622-1629. [DOI] [Repository]
van Aalst, S., Ludwig, I. S., van der Zee, R., van Eden, W., & Broere, F. (2017). Bystander activation of irrelevant CD4+ T cells following antigen-specific vaccination occurs in the presence and absence of adjuvant. PLoS One, 12(5), 1-13. [DOI]
2016
Scholarly publications
De Wolf, C., Van Der Zee, R., Den Braber, I., Glant, T., Maill??re, B., Favry, E., Van Lummel, M., Koning, F., Hoek, A., Ludwig, I., Van Eden, W., & Broere, F. (2016). An Arthritis-Suppressive and Treg Cell-Inducing CD4+ T Cell Epitope is Functional in the Context of HLA-Restricted T Cell Responses. In Arthritis and Rheumatology (pp. 639-647). (Arthritis and Rheumatology; Vol. 68, No. 3). John Wiley and Sons Inc.. [DOI] [Repository]
Jansen, M. A. A., Van Herwijnen, M. J. C., Van Kooten, P. J. S., Hoek, A., Van Der Zee, R., Van Eden, W., & Broere, F. (2016). Generation of the first TCR transgenic mouse with CD4+ T cells recognizing an anti-inflammatory regulatory T cell-inducing Hsp70 peptide. Frontiers in Immunology, 7, Article 90. [DOI] [Repository]
Lord, P., Aguillon, J. C., Anderson, A. E., Appel, S., Benitez-Ribas, D., Ten Brinke, A., Broere, F., Cools, N., Cuturi, M. C., Diboll, J., Geissler, E. K., Giannoukakis, N., Gregori, S., van Ham, S. M., Lattimer, S., Marshall, L., Harry, R. A., Hutchinson, J. A., Isaacs, J. D., ... Hilkens, C. M. U. (2016). Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies. PeerJ [E], 4, Article e2300. [DOI] [Repository]
Barberá, A., Lorenzo, N., van Kooten, P., van Roon, J., de Jager, W., Prada, D., Gómez, J., Padrón, G., van Eden, W., Broere, F., & Del Carmen Domínguez, M. (2016). APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients. Cell Stress & Chaperones, 21(4), 735-744. [DOI] [Repository]
2015
Scholarly publications
Zeng, X., de Groot, A. M., Sijts, A. J. A. M., Broere, F., Oude Blenke, E., Colombo, S., van Eden, W., Franzyk, H., Nielsen, H. M., & Foged, C. (2015). Surface coating of siRNA-peptidomimetic nano-self-assemblies with anionic lipid bilayers: enhanced gene silencing and reduced adverse effects in vitro. Nanoscale, 7(46), 19687-19698. [DOI] [Portal]
Delemarre, E. M., van den Broek, T., Mijnheer, G., Meerding, J., Wehrens, E. J., Olek, S., Boes, M., van Herwijnen, M. J. C., Broere, F., van Royen, A., Wulffraat, N. M., Prakken, B. J., Spierings, E., & van Wijk, F. (2015). Autologous stem cell transplantation benefits autoimmune patients through functional renewal and TCR diversification of the regulatory T cell compartment. Blood, 127(1), 91-101. [DOI]
van Herwijnen, M. J. C., van der Zee, R., van Eden, W., & Broere, F. (2015). In Vivo Induction of Functionally Suppressive Induced Regulatory T Cells from CD4+CD25- T Cells Using an Hsp70 Peptide. PLoS One, 10(6), Article e0128373. [DOI] [Repository]
Spiering, R., Margry, B., Keijzer, C., Petzold, C., Hoek, A., Wagenaar-Hilbers, J., van der Zee, R., van Eden, W., Kretschmer, K., & Broere, F. (2015). DEC205+ Dendritic Cell-Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis. Journal of Immunology. [DOI] [Portal]
de Geus, E. D., Degen, W. G. J., van Haarlem, D. A., Schrier, C., Broere, F., & Vervelde, L. (2015). Distribution patterns of mucosally applied particles and characterisation of the antigen presenting cells. Avian Pathology, 44(3), 222-229. [DOI] [Repository]
Swart, J. F., de Roock, S., Hofhuis, F. M., Rozemuller, H., van den Broek, T., Moerer, P., Broere, F., van Wijk, F., Kuis, W., Prakken, B. J., Martens, A. C. M., & Wulffraat, N. M. (2015). Mesenchymal stem cell therapy in proteoglycan induced arthritis. Annals of the Rheumatic Diseases, 74(4), 769-777. [DOI] [Repository]
2014
Scholarly publications
De Jong, H., Koffeman, E. C., Meerding, J. M., Scholman, R. C., Wieten, L., De Jager, W., Klein, M., Otten, H., Van Wijk, F., Van Der Zee, R., Bijlsma, J. W. J., Broere, F., Van Eden, W., & Prakken, B. J. (2014). T cell recognition of naturally presented epitopes of self-heat shock protein 70. Cell Stress & Chaperones, 19(4), 569-578. [DOI]
Jassies-Van Der Lee, A., Rutten, V. P. M. G., Bruijn, J., Willemse, T., & Broere, F. (2014). CD4+ and CD8+ skin-associated T lymphocytes in canine atopic dermatitis produce interleukin-13, interleukin-22 and interferon-γ and contain a CD25+FoxP3+ subset. Veterinary Dermatology, 25(5), 456-72. [DOI] [Repository]
Jassies-van der Lee, A., Rutten, V., Spiering, R., van Kooten, P., Willemse, T., & Broere, F. (2014). The immunostimulatory effect of CpG oligodeoxynucleotides on peripheral blood mononuclear cells of healthy dogs and dogs with atopic dermatitis. Veterinary Journal, 200(1), 103-108. [DOI]
Margry, B., Kersemakers, S. C. W., Hoek, A., Arkesteijn, G. J. A., Wieland, W. H., van Eden, W., & Broere, F. (2014). Activated Peritoneal Cavity B-1a Cells Posses Regulatory B Cell Properties. PLoS One, 9(2), 1-8. Article e88869. [DOI] [Repository]
Spiering, R., Wagenaar-Hilbers, J., Huijgen, V., Van der Zee, R., Van Kooten, P. J. S., Van Eden, W., & Broere, F. (2014). Membrane-bound metallothionein 1 of murine dendritic cells promotes the expansion of regulatory T cells in vitro. Toxicological Sciences, 138(1), 69-75. [DOI]
Keijzer, C., Haijema, B. J., Meijerhof, R., Voorn, P., de Haan, A., Leenhouts, K., van Roosmalen, M., van Eden, W., & Broere, F. (2014). Inactivated influenza vaccine adjuvanted with Bacterium-like particles induce systemic and mucosal influenza A virus specific T-celland B-cell responses after nasal administration in a TLR2 dependent fashion. Vaccine. [DOI]
Delemarre, E. M., Roord, S. T. A., van den Broek, T., Zonneveld - Huijssoon, E., de Jager, W., Rozemuller, H., Martens, A. C. M., Broere, F., Wulffraat, N. M., Glant, T., Prakken, B. J., & van Wijk, F. (2014). Autologous Stem Cell Transplantation Restores Immune Tolerance in Experimental Arthritis by Renewal and Modulation of the Teff Cell Compartment. Arthritis & Rheumatology, 66(2), 350-356. [DOI]
2013
Scholarly publications
Margry, B., Wieland, W. H., van Kooten, P., van Eden, W., & Broere, F. (2013). Peritoneal cavity B-1a cells promote peripheral CD4(+) T-cell activation. European Journal of Immunology, 43, 2317-2326. [DOI]
Barberá, A., Lorenzo, N., Mazola, Y., Falcón, V., Torres, A. M., Hernández, M. I., Hernández, M. V., Margry, B., de Groot, A. M., van Roon, J. A. G., van der Zee, R., Broere, F., van Eden, W., Padrón, G., & Domínguez, M. D. C. (2013). APL-1, an altered peptide ligand derived from human heat-shock protein 60, selectively induces apoptosis in activated CD4+ CD25+ T cells from peripheral blood of rheumatoid arthritis patients. International Immunopharmacology, 17(4), 1075-1083. [DOI]
Keijzer, C., van der Zee, R., van Eden, W., & Broere, F. (2013). Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases. Frontiers in Immunology [E], 245. [DOI] [Repository]
van Eden, W., van Herwijnen, M. J. C., Wagenaar, J., van Kooten, P., Broere, F., & van der Zee, R. (2013). Stress proteins are used by the immune system for cognate interactions with anti-inflammatory regulatory T cells. FEBS Letters, 587, 1951-1958. [DOI]
Looringh van Beeck, F. A., Leegwater, P. A. J., Herrmann, T., Broere, F., Rutten, V. P. M. G., Willemse, T., & van Rhijn, I. (2013). Tandem repeats modify the structure of the canine CD1D gene. Animal Genetics, 44, 352-355. [DOI]
van Herwijnen, M. J. C., van der Zee, R., van Eden, W., & Broere, F. (2013). Heat shock proteins can be targets of regulatory T cells for therapeutic intervention in rheumatoid arthritis. International Journal of Hyperthermia, 29, 448-454. [DOI]
Spiering, R., van der Zee, R., Wagenaar, J. A., van Eden, W., & Broere, F. (2013). Mycobacterial and mouse HSP70 have immuno-modulatory effects on dendritic cells. Cell Stress & Chaperones, 18, 439-446. [DOI] [Repository]
Keijzer, C., Spiering, R., Silva, A. L., van Eden, W., Jiskoot, W., Vervelde, L., & Broere, F. (2013). PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3(+) T-cells in vitro. Journal of Controlled Release, 168(1), 35-40. [DOI]
2012
Scholarly publications
Keijzer, C., Wieten, L., van Herwijnen, M. J. C., van der Zee, R., van Eden, W., & Broere, F. (2012). Heat shock proteins are therapeutic targets in autoimmune diseases and other chronic inflammatory conditions. Expert Opinion on Therapeutic Targets, 16(9), 849-857. [DOI]
Borges, T. J., Wieten, L., van Herwijnen, M. J. C., Broere, F., van der Zee, R., Bonorino, C., & van Eden, W. (2012). The anti-inflammatory mechanisms of Hsp70. Frontiers in Immunology [E], 3, 10.3389/fimmu.2012.00095. Article 95. [DOI] [Repository]
van Herwijnen, M. J. C., Wieten, L., van der Zee, R., van Kooten, P. J., Wagenaar, J. P. A., Hoek, A., den Braber, A. J., Anderton, S. M., Singh, M., Meiring, H. D., van Els, C. A. C. M., van Eden, W., & Broere, F. (2012). Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis. Proceedings of the National Academy of Sciences of the United States of America, 109(35), 14134-14139. [DOI]
Spiering, R., van der Zee, R., Wagenaar, J. P. A., Kapetis, F., Zolezzi, F., van Eden, W., & Broere, F. (2012). Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress. PLoS One, 7(9), 10.1371/journal.pone.0046336. [DOI] [Repository]
van Eden, W., Spiering, R., Broere, F., & van der Zee, R. (2012). A case of mistaken identity: HSPs are no DAMPs but DAMPERs. Cell Stress & Chaperones, 17, 281-292. [DOI] [Repository]
2011
Scholarly publications
Keijzer, C., Slutter, B., van der Zee, R., Jiskoot, W., van Eden, W., & Broere, F. (2011). PLGA, PLGA-TMC and TMC-TPP nanoparticles differentially modulate the outcome of nasal vaccination by inducing tolerance or enhancing humoral immunity. PLoS One, 6(11), 10.1371/journal.pone.0026684. [DOI] [Repository]
Fleur du Pre, M., van Berkel, L. A., Raki, M., van Leeuwen, M., de Ruiter, L. F., Broere, F., ter Borg, M. N. D., Lund, F. E., Escher, J. C., Lundin, K. E. A., Sollid, L. M., Kraal, G., Nieuwenhuis, E. E. S., & Samson, J. N. (2011). CD62LnegCD38+ expression on circulating CD4+ T cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls. American Journal of Gastroenterology, 106, 1147-1159. [DOI]
Gomes Coimbra, M. J., Isacchi, B., van Bloois, L., Sastre Torano, J., Ket, A., Wu, X., Broere, F., Metselaar, J. M., Rijcken, C. J. F., Storm, G., Bilia, R., & Schiffelers, R. M. (2011). Improving solubitity and chemical stability of natural compounds for medicinal use by incorporation into liposomes. International Journal of Pharmaceutics, 416(2), 433-442. [DOI]
Ojeda, G., Pini, E., Eguiluz, C., Montes-Casado, M., Broere, F., van Eden, W., Rojo, J., & Portoles, P. (2011). Complement regulatory protein Crry/p65 costimulation expands natural Treg cells with enhanced suppressive properties in proteoglycan-induced arthritis. Arthritis and Rheumatism, 63(6), 1562-1572.
Hartgring, S. A. Y., Willis, C. R., Dean, C. E., Broere, F., van Eden, W., Bijlsma, J. W. J., Lafeber, F. P. J. G., & van Roon, J. A. G. (2011). Critical proinflammatory role of thymic stromal lymphopoietin and its receptor in experimental autoimmune arthritis. Arthritis and Rheumatism, 63(7), 1878-1887. [DOI]
Broere, F., van der Zee, R., & van Eden, W. (2011). Heat shock proteins are no DAMPs, rather 'DAMPERs'. Nature Reviews. Immunology, 11(8), 565-565. [DOI]
Broere, F., Apasov, S., Sitkovsky, M. V., & van Eden, W. (2011). T cell subsets and T cell-mediated immunity. In Principles of immunopharmacology Springer.
Broere, F., Berlo, S. E., Guichelaar, T., Wieten, L., van der Zee, R., & van Eden, W. (2011). HSP reactive T cells are anti-inflammatory and disease suppressive in arthritic diseases. In Heat shock proteins and whole body physiology (pp. 85-101). Springer. [DOI]
2010
Scholarly publications
Slutter, B., Bal, S., Keijzer, C., Mallants, R., Hagenaars, N., Que, I., Kaijzel, E. L., van Eden, W., Augustijns, P., Lowik, C., Bouwstra, J. A., Broere, F., & Jiskoot, W. (2010). Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: Nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen. Vaccine, 28(38), 6282-6291. [DOI]
Wieten, L., van der Zee, R., Goedemans, R., Sijtsma, J., Serafini, M., Lubsen, N. H., van Eden, W., & Broere, F. (2010). Hsp70 expression and induction as a readout for detection of immune modulatory components in food. Cell Stress & Chaperones, 15, 25-37. [DOI]
Wieten, L., van der Zee, R., Spiering, R., Wagenaar-Hilbers, J. P. A., van Kooten, P. J., Broere, F., & van Eden, W. (2010). A novel heat-shock protein coinducer boosts stress protein Hsp70 to activate T cell regulation of inflammation in autoimmune arthritis. Arthritis and Rheumatism, 62(4), 1026-1035. [DOI]
2009
Scholarly publications
Wieten, L., Berlo, S. E., ten Brink, C. B. M., van Kooten, P. J., Singh, M., van der Zee, R., Glant, T., Broere, F., & van Eden, W. (2009). IL-10 is critically involved in mycobacterial HSP70 induced suppression of proteoglycan-induced arthritis. PLoS One, 4(1), e4186. [Repository]
Broere, F., du Pre, M. F., van Berkel, L. A., Garssen, J., Scmidt-Weber, C. B., Lambrecht, B. N., Hendriks, R. W., Nieuwenhuis, E. E. S., Kraal, G., & Samson, J. (2009). Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4. Mucosal Immunology, 2(3), 254-264.
2008
Scholarly publications
Looringh van Beeck, F. A., Zajonc, D. M., Moore, P. F., Schlotter, Y. M., Broere, F., Rutten, V. P. M. G., Willemse, A., & van Rhijn, I. (2008). Two canine CD1a proteins are differentially expressed in skin. Immunogenetics, 60(6), 315-234. [Repository]
Guichelaar, T., ten Brink, C. B. M., van Kooten, P. J., Berlo, S. E., Broeren, C. P. M., van Eden, W., & Hauet-Broere, F. (2008). Autoantigen-specific IL-10-transduced T cells suppress chronic arthritis by promoting the endogenous regulatory IL-10 response. Journal of Immunology, 180, 1373-1381. [Repository]
Coelho, V., Broere, F., Binder, R. J., Shoenfeld, Y., & Moudgil, K. D. (2008). Heat-shock proteins: Inflammatory versus regulatory attributes. Cell Stress & Chaperones, 13, 119-125.
Broere, F., Wieten, L., Klein Koerkamp, E. I., van Roon, J. A. G., Guichelaar, T., Lafeber, F. P. J. G., & van Eden, W. (2008). Oral or nasal antigen induces regulatory T cells that suppress arthritis and proliferation of arthritogenic T cells in joint draining lymph nodes. Journal of Immunology, 181(2), 899-906.
Guichelaar, T., ten Brink, C. B. M., van Kooten, P. J., Berlo, S. E., Lafeber, F. P. J. G., Broeren, C. P. M., van Eden, W., & Hauet-Broere, F. (2008). Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis. Molecular Immunology, 45(13), 3526-3535. [Repository]
2007
Scholarly publications
Wieten, L., Hauet-Broere, F., van der Zee, R., Klein Koerkamp, E., Wagenaar-Hilbers, J. P. A., & van Eden, W. (2007). Cell stress induced HSP are targets of regulatory T cells: a role for HSP inducing compounds as anti-inflammatory immuno-modulators? FEBS Letters, 581(19), 3716-3722. [Repository]
Other output
Swart, J. F., Backer, M. J. G., Rozemuller, H., Hauet-Broere, F., Berlo, S. E., Prakken, A. B. J., van Wijk, F., Wulffraat, N. M., & Martens, A. C. (2007). Single Mesenchymal Stem Cell Injection after Disease onset Suppressed Progression of Proteoglycan Induced Arthritis. Poster session presented at Unknown event, Asilomar, USA.
Swart, J. F., Backer, M. J. G., Rozemuller, H., Hauet-Broere, F., Berlo, S. E., Prakken, A. B. J., van Wijk, F., Wulffraat, N. M., & Martens, A. C. (2007). Single injection of Mesenchymal Stem Cells decreases progression of proteoglycan induced arthritis. Poster session presented at EULAR, Barcelona 2007.
2006
Scholarly publications
Berlo, S. E., Guichelaar, T., ten Brink, C. B. M., van Kooten, P. J., Hauet-Broere, F., Ludanyi, K., van Eden, W., Broeren, C. P. M., & Glant, T. (2006). Increased arthritis susceptibility in cartilage proteoglycan-specific T cell receptor-transgenic mice. Arthritis and Rheumatism, 54(8), 2423-2433. [Repository]
Hauet-Broere, F., Wieten, L., Guichelaar, T., van Berlo, J., van der Zee, R., & van Eden, W. (2006). Heat shock proteins induce T cell regulation of chronic inflammation. Annals of the Rheumatic Diseases, 65, iii65-iii68. [Repository]
Other output
Garssen, J., Broere, F., Kraal, G., & Samsom, J. N. (2006). Tolerance induction and regulatory T cells. Poster session presented at NVVI, Noordwijkerhout.
2005
Scholarly publications
van Eden, W., Hauet-Broere, F., Berlo, S. E., Paul, L., van der Zee, R., de Kleer, I. M., Prakken, A. B. J., & Taams, L. S. (2005). Stress proteins as inducers and targets of regulatory T Cells in arthritis. International Reviews of Immunology, 24, 1-16.
Berlo, S. E., van Kooten, P. J., ten Brink, C. B. M., Hauet-Broere, F., Oosterwegel, M. A., Glant, T., van Eden, W., & Broeren, C. P. M. (2005). Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation. Journal of Autoimmunity, 25(3), 172-180.
2003
Scholarly publications
Hauet-Broere, F., Unger, W. W. J., Garssen, J., Hoijer, M. A., Kraal, G., & Samsom, J. N. (2003). Functional CD25- and CD25+ mucosal regulatory T cells are induced in gut-draining lymphoid tissue within 48 h after oral antigen application. European Journal of Immunology, 33(10), 2801-2810. [DOI]