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Dr. E.Y. (Liesbeth) Bijlsma

Associate Professor 
Science
Pharmaceutical sciences
Pharmacology
Pharmacology
David de Wiedgebouw
Universiteitsweg 99
Kamer 3.84
3584 CG Utrecht

Dr. E.Y. (Liesbeth) Bijlsma

Associate Professor
Pharmacology
+31 6 10 031 691
e.y.bijlsma@uu.nl
Profile CV Publications Activities Prizes In the media Research Teaching Contact
Profile CV Publications Activities Prizes In the media Research Teaching Contact
Areas of expertise
Skills
Research areas

Publications

2025

Scholarly publications

Heesbeen, E. J., Bijlsma, E. Y., Risseeuw, T. A., Hessel, E. V. S., & Groenink, L. (2025). A systematic approach to identify gaps in neuroimmunology: TNF-α and fear learning deficits, a worked example. Brain, Behavior, and Immunity, 123, 752-764. https://doi.org/10.1016/j.bbi.2024.10.027
https://research-portal.uu.nl/ws/files/243878030/1-s2.0-S0889159124006688-main.pdf

2024

Scholarly publications

Hendriksen, P. A., Moormann, I., Bijlsma, L., Mulder, K. EW., van Oostrom, E. C., Verheul, M. CE., Engels, F., Garssen, J., Devenney, L. E., & Verster, J. (2024). The Academic Functioning Scale: validity and reliability. International Journal of Humanities Social Sciences and Education, 11(11), 105-112. https://www.arcjournals.org/pdfs/ijhsse/v11-i11/9.pdf
Heesbeen, E. J., van Kampen, T., Verdouw, P. M., van Lissa, C., Bijlsma, E. Y., & Groenink, L. (2024). The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies. Psychopharmacology, 241(9), 1731-1755. https://doi.org/10.1007/s00213-024-06645-2
https://research-portal.uu.nl/ws/files/237160927/s00213-024-06645-2.pdf

2023

Scholarly publications

Heesbeen, E. J., Bijlsma, E. Y., Verdouw, P. M., van Lissa, C., Hooijmans, C., & Groenink, L. (2023). The effect of SSRIs on fear learning: a systematic review and meta-analysis. Psychopharmacology, 240(11), 2335-2359. https://doi.org/10.1007/s00213-023-06333-7
https://dspace.library.uu.nl/bitstream/handle/1874/432973/s00213-023-06333-7.pdf?sequence=1
Groenink, L., Verdouw, P. M., Zhao, Y., Ter Heegde, F., Wever, K. E., & Bijlsma, E. Y. (2023). Pharmacological modulation of conditioned fear in the fear-potentiated startle test: a systematic review and meta-analysis of animal studies. Psychopharmacology, 240(11), 2361-2401. https://doi.org/10.1007/s00213-022-06307-1
https://dspace.library.uu.nl/bitstream/handle/1874/432932/s00213-022-06307-1.pdf?sequence=1

2022

Scholarly publications

Heesbeen, E., Verdouw, M., van Lissa, C., Hooijmans, C., Bijlsma, L., & Groenink, L. (2022). The effect of selective serotonin reuptake inhibitors on fear learning: a systematic review and meta-analysis. Neuroscience Applied, 1(S2), Article 100144. https://doi.org/10.1016/j.nsa.2022.100144
https://dspace.library.uu.nl/bitstream/handle/1874/426696/1_s2.0_S2772408522001442_main.pdf?sequence=1

Professional publications

ten Berge, H., Slot, E., Bijlsma, L., & Engels, F. (2022). Teaching presence: hoe faciliteer je online samenwerkend leren in het hoger onderwijs? Een systematisch literatuuronderzoek . Universiteit Utrecht. https://www.uu.nl/onderwijs/onderwijsadvies-training/kennisdossiers/kennisdossier-hoger-onderwijs/samenwerkend-leren-vormgeven-in-online-onderwijs
https://dspace.library.uu.nl/bitstream/handle/1874/425251/Online_collaborative_learning_in_HE_NL.pdf?sequence=3

2021

Scholarly publications

Hendriksen, P. A., Merlo, A., Bijlsma, E. Y., Engels, F., Garssen, J., Bruce, G., & Verster, J. C. (2021). Covid-19 lockdown effects on academic functioning, mood, and health correlates: Data from dutch pharmacy students, phd candidates and postdocs. Data, 6(11), 1-9. Article 120. https://doi.org/10.3390/data6110120
https://dspace.library.uu.nl/bitstream/handle/1874/425383/data_06_00120_v2.pdf?sequence=1
Merlo, A., Hendriksen, P. A., Garssen, J., Bijlsma, E. Y., Engels, F., Bruce, G., & Verster, J. C. (2021). Transition to Online Education during the COVID-19 Pandemic: Impact of Changes in Alcohol Consumption and Experiencing Hangovers on Academic Functioning. Journal of Clinical Medicine, 10(22), 1-16. Article 5332. https://doi.org/10.3390/jcm10225332
https://dspace.library.uu.nl/bitstream/handle/1874/419710/jcm_10_05332_v2.pdf?sequence=1
Hendriksen, P. A., Garssen, J., Bijlsma, E. Y., Engels, F., Bruce, G., & Verster, J. C. (2021). COVID-19 Lockdown-Related Changes in Mood, Health and Academic Functioning. European Journal of Investigation in Health, Psychology and Education, 11(4), 1440-1461. https://doi.org/10.3390/ejihpe11040103
https://dspace.library.uu.nl/bitstream/handle/1874/419707/ejihpe_11_00103.pdf?sequence=1

2019

Scholarly publications

Zhao, Y., Bijlsma, E. Y., Ter Heegde, F., Verdouw, M. P., Garssen, J., Newman-Tancredi, A., & Groenink, L. (2019). Activation of somatodendritic 5-HT1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test. Psychopharmacology, 236(4), 1171–1185. https://doi.org/10.1007/s00213-018-5124-0
https://dspace.library.uu.nl/bitstream/handle/1874/391644/Zhao2019_Article_ActivationOfSomatodendritic5_H.pdf?sequence=1

2018

Scholarly publications

Zhao, Y., Bijlsma, E. Y., Verdouw, M. P., & Groenink, L. (2018). No effect of sex and estrous cycle on the fear potentiated startle response in rats. Behavioural Brain Research, 351, 24-33. https://doi.org/10.1016/j.bbr.2018.05.022
https://dspace.library.uu.nl/bitstream/handle/1874/372830/zhao.pdf?sequence=1
Zhao, Y., Bijlsma, E. Y., Verdouw, P. M., Garssen, J., & Groenink, L. (2018). The contribution of contextual fear in the anxiolytic effect of chlordiazepoxide in the fear-potentiated startle test. Behavioural Brain Research, 353, 57-61. https://doi.org/10.1016/j.bbr.2018.06.035
https://dspace.library.uu.nl/bitstream/handle/1874/373619/contextual.pdf?sequence=1

2015

Scholarly publications

Bijlsma, E. Y., Hendriksen, H., Baas, J. M. P., Millan, M. J., & Groenink, L. (2015). Lifelong disturbance of serotonin transporter functioning results in fear learning deficits: Reversal by blockade of CRF1 receptors. European Neuropsychopharmacology, 25(10), 1733-1743. https://doi.org/10.1016/j.euroneuro.2015.07.004
https://dspace.library.uu.nl/bitstream/handle/1874/325531/29_main.pdf?sequence=1
Kasahara, M., Groenink, L., Bijlsma, E. Y., Olivier, B., & Sarnyai, Z. (2015). Lifelong, central corticotropin-releasing factor (CRF) overexpression is associated with individual differences in cocaine-induced conditioned place preference. European Journal of Pharmacology, 753, 151-157. https://doi.org/10.1016/j.ejphar.2014.07.050
https://dspace.library.uu.nl/bitstream/handle/1874/432893/1-s2.0-S0014299914005901-main.pdf?sequence=1

2014

Scholarly publications

Bijlsma, E. Y., Chan, J. S. W., Olivier, B., Veening, J. G., Millan, M. J., Waldinger, M. D., & Oosting, R. S. (2014). Sexual side effects of serotonergic antidepressants: Mediated by inhibition of serotonin on central dopamine release? Pharmacology, Biochemistry and Behavior, 121, 88-101.

2013

Scholarly publications

Van Gool, J. M., Baas, J. M. P., Heitland, I., Bijlsma, E. Y., & Groenink, L. (2013). A translational look at the serotonin transporter and corticotropin-releasing hormone in the acquisition of adaptive fear responses. European Neuropsychopharmacology, 23, 529-530. https://doi.org/10.1016/S0924-977X(13)70840-X
Heitland, I., Groenink, L., Bijlsma, E. Y., Oosting, R. S., & Baas, J. M. P. (2013). Corticotropin releasing hormone and serotonin-the neuropsychopharmacology of fear learning deficit from rodents to humans. European Neuropsychopharmacology, 23, 130. https://doi.org/10.1016/S0924-977X(13)70172-X
Heitland, I., Groenink, L., Bijlsma, E. Y., Oosting, R. S., & Baas, J. M. P. (2013). Human fear acquisition deficits in relation to genetic variants of the corticotropin releasing hormone receptor 1 and the serotonin transporter. PLoS One, 8(5), Article e63772. https://doi.org/10.1371/journal.pone.0063772

Other output

Heitland, I., Bijlsma, E. Y., Groenink, L., Evers, D., Oosting, R. S., Kenemans, J. L., & Baas, J. M. P. (2013). Human fear learning deficits depend on genetic variability in corticotropin releasing hormone receptor 1 in interaction with serotonergic polymorphisms. Poster session presented at Society for Neuroscience, San Diego, CA, USA.
Heitland, I., Groenink, L., Bijlsma, E. Y., Oosting, R. S., & Baas, J. M. P. (2013). Human fear learning deficits depend on genetic variability in corticotropin releasing hormone receptor 1 in interaction with serotonergic polymorphisms. Poster session presented at ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nice, France.

2012

Other output

Bijlsma, E. Y., van Gool, J. M., Baas, J. M. P., Olivier, B., & Groenink, L. (2012). Lifelong, but not acute or chronic, inactivation of the serotonin transporter hampers fear learning in rat fear-potentiated startle.. Paper presented at Society for Neuroscience, San Diego, CA, USA.

2011

Scholarly publications

Groenink, L., Bijlsma, E. Y., van Bogaert, M. J. V., Oosting, R. S., & Olivier, B. (2011). Serotonin1A receptor deletion does not interact with maternal separation-induced increases in startle reactivity and prepulse inhibition deficits. Psychopharmacology, 214(1), 353-365. https://doi.org/10.1007/s00213-010-1998-1
Kasahara, M., Groenink, L., Kas, M. J. H., Bijlsma, E. Y., Olivier, B., & Sarnyai, Z. (2011). Influence of transgenic corticotropin-releasing factor (CRF) over-expression on social recognition memory in mice. Behavioural Brain Research, 218(2), 357-362. https://doi.org/10.1016/j.bbr.2010.12.029
Bijlsma, E. Y., van Leeuwen, M. L. F., Westphal, K. G. C., Olivier, B., & Groenink, L. (2011). Local repeated corticotropin-releasing factor infusion exacerbates anxiety- and fear-related behavior: differential involvement of the basolateral amygdala and medial prefrontal cortex. Neuroscience, 173, 82-92. https://doi.org/10.1016/j.neuroscience.2010.11.026

2010

Scholarly publications

Bijlsma, E. Y. (2010). Affective startle modulation : psychopharmacological studies on the roles of CRF and serotonin in the regulation of emotions. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/188213/bijlsma.jpg?sequence=1
Vinkers, C. H., Bijlsma, E. Y., Houtepen, L. C., Westphal, K. G. C., Veening, J. G., Groenink, L., & Olivier, B. (2010). Medial amygdala lesions differentially influence stress responsivity and sensorimotor gating in rats. Physiology & behavior, 99(3), 395-401.
Bijlsma, E. Y., Oosting, R. S., Olivier, B., & Groenink, L. (2010). Disrupted startle modulation in animal models for affective disorders. Behavioural Brain Research, 208(2), 383-90.
Bijlsma, E. Y., de Jongh, R., Olivier, B., & Groenink, L. (2010). Fear-potentiated startle, but not light-enhanced startle, is enhanced by anxiogenic drugs. Pharmacology, Biochemistry and Behavior, 96(1), 24-31.
Bijlsma, E. Y., Olivier, B., & Groenink, L. (2010). Cocaine-induced changes in affective state modulate the light-enhanced startle response. Behavioural Brain Research, 213(1), 117-20.

2008

Scholarly publications

Groenink, L., Bijlsma, E. Y., & Olivier, B. (2008). Fear-potentiated startle and light-enhanced startle models in drug discovery. Current Protocols in Pharmacology, (SUPPL. 41). https://doi.org/10.1002/0471141755.ph0548s41
Groenink, L., Bijlsma, E. Y., & Olivier, B. (2008). Fear-potentiated startle and light-enhanced startle models in drug dicovery. Current Protocols in Pharmacology, 5.48.1-5.48.15.
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