Publications
2023
Scholarly publications
Lyu, Q., Veldhuizen, E. J. A., Ludwig, I. S., Rutten, V. P. M. G., van Eden, W., Sijts, A. J. A. M., & Broere, F. (2023). Characterization of polarization states of canine monocyte derived macrophages. PLoS One, 18(11), Article e0292757. https://doi.org/10.1371/journal.pone.0292757
Javed, A., Balhuizen, M. D., Pannekoek, A., Bikker, F. J., Heesterbeek, D. A. C., Haagsman, H. P., Broere, F., Weingarth, M., & Veldhuizen, E. J. A. (2023). Effects of Escherichia coli LPS Structure on Antibacterial and Anti-Endotoxin Activities of Host Defense Peptides. Pharmaceuticals (Basel, Switzerland), 16(10), Article 1485. https://doi.org/10.3390/ph16101485
Ijaz, A., Broere, F., Rutten, V. P. M. G., Jansen, C. A., & Veldhuizen, E. J. A. (2023). Perforin and granzyme A release as novel tool to measure NK cell activation in chickens. Developmental and Comparative Immunology, 149, Article 105047. https://doi.org/10.1016/j.dci.2023.105047
van der Krift, F., Zijlmans, D. W., Shukla, R., Javed, A., Koukos, P. I., Schwarz, L. LE., Timmermans-Sprang, E. P., Maas, P. E., Gahtory, D., van den Nieuwboer, M., Mol, J. A., Strous, G. J., Bonvin, A. M., van der Stelt, M., Veldhuizen, E. J., Weingarth, M., Vermeulen, M., Klumperman, J., & Maurice, M. M. (2023). A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance. Life Science Alliance, 6(11), Article e202302058. https://doi.org/10.26508/lsa.202302058
Javed, A., Slingerland, C. J., Wood, T. M., Martin, N. I., Broere, F., Weingarth, M. H., & Veldhuizen, E. J. A. (2023). Chimeric Peptidomimetic Antibiotic Efficiently Neutralizes Lipopolysaccharides (LPS) and Bacteria-Induced Activation of RAW Macrophages. ACS Infectious Diseases , 9(3), 518-526. https://doi.org/10.1021/acsinfecdis.2c00518
Kunchala, S. R., van Dijk, A., Veldhuizen, E. J. A., Donnellan, S. C., Haagsman, H. P., & Orgeig, S. (2023). Avian surfactant protein (SP)-A2 first arose in an early tetrapod before the divergence of amphibians and gradually lost the collagen domain. Developmental and Comparative Immunology, 139, 1-14. Article 104582. https://doi.org/10.1016/j.dci.2022.104582
Safeer, A., Kleijburg, F., Bahri, S., Beriashvili, D., Veldhuizen, E., van Neer, J., Tegelaar, M., de Cock, H., Wösten, H., & Baldus, M. (2023). Probing Cell-Surface Interactions in Fungal Cell Walls by High-Resolution 1H-detected Solid-State NMR Spectroscopy. Chemistry-A European Journal, 29(1), Article e202202616. https://doi.org/10.1002/chem.202202616
2022
Scholarly publications
van Dijk, A., Anten, J., Bakker, A., Evers, N., Hoekstra, A. T., Chang, J.-C., Scheenstra, M. R., Veldhuizen, E. J. A., Netea, M. G., Berkers, C. R., & Haagsman, H. P. (2022). Innate Immune Training of Human Macrophages by Cathelicidin Analogs. Frontiers in Immunology, 13, 1-18. Article 777530. https://doi.org/10.3389/fimmu.2022.777530
van Os, N., Javed, A., Broere, F., van Dijk, A., Balhuizen, M. D., van Eijk, M., Rooijakkers, S. H. M., Bardoel, B. W., Heesterbeek, D. A. C., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Novel insights in antimicrobial and immunomodulatory mechanisms of action of PepBiotics CR-163 and CR-172. Journal of Global Antimicrobial Resistance, 30, 406-413. https://doi.org/10.1016/j.jgar.2022.07.009
Balhuizen, M. D., Versluis, C. M., van Grondelle, M. O., Veldhuizen, E. J. A., & Haagsman, H. P. (2022). Modulation of outer membrane vesicle-based immune responses by cathelicidins. Vaccine, 40(16), 2399-2408. https://doi.org/10.1016/j.vaccine.2022.03.015
Peng, L., Lu, Y., Tian, H., Jia, K., Tao, Q., Li, G., Wan, C., Ye, C., Veldhuizen, E. J. A., Chen, H., & Fang, R. (2022). Chicken cathelicidin-2 promotes IL-1β secretion via the NLRP3 inflammasome pathway and serine proteases activity in LPS-primed murine neutrophils. Developmental and Comparative Immunology, 131, 1-9. Article 104377. https://doi.org/10.1016/j.dci.2022.104377
https://dspace.library.uu.nl/bitstream/handle/1874/420691/1_s2.0_S0145305X22000398_main.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/420691/1_s2.0_S0145305X22000398_main.pdf?sequence=1
Bosso, A., Gaglione, R., Di Girolamo, R., Veldhuizen, E. J. A., García-Vello, P., Fusco, S., Cafaro, V., Monticelli, M., Culurciello, R., Notomista, E., Arciello, A., & Pizzo, E. (2022). Human Cryptic Host Defence Peptide GVF27 Exhibits Anti-Infective Properties against Biofilm Forming Members of the
Burkholderia cepacia Complex. Pharmaceuticals (Basel, Switzerland), 15(2), 1-21. Article 260. https://doi.org/10.3390/ph15020260
Cesaro, A., Torres, M. D. T., Gaglione, R., Dell'Olmo, E., Di Girolamo, R., Bosso, A., Pizzo, E., Haagsman, H. P., Veldhuizen, E. J. A., de la Fuente-Nunez, C., & Arciello, A. (2022). Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma. ACS Nano, 16(2), 1880-1895. https://doi.org/10.1021/acsnano.1c04496
Harten, R. M. V., Bokhoven, J. L. M. T., Greeff, A. D., Balhuizen, M. D., Dijk, A. V., Veldhuizen, E. J. A., Haagsman, H. P., & Scheenstra, M. R. (2022). d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2. Journal of Advanced Research, 36, 101-112. https://doi.org/10.1016/j.jare.2021.05.009
van Harten, R. M., Veldhuizen, E. J. A., Haagsman, H. P., & Scheenstra, M. R. (2022). The cathelicidin CATH-2 efficiently neutralizes LPS- and E. coli-induced activation of porcine bone marrow derived macrophages. Veterinary Immunology and Immunopathology, 244, 1-8. Article 110369. https://doi.org/10.1016/j.vetimm.2021.110369
Verheije, M. H., Coorens, M., Weerts, E. A. W. S., Berends, A. J., van Harten, R. M., Angel, M., Kooij, J., Ordonez, S. R., van Beurden, S. J., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Antiviral activity of selected cathelicidins against infectious bronchitis virus. Peptide Science, 114(1), 1-8. Article e24234. https://doi.org/10.1002/pep2.24234
2021
Scholarly publications
Ijaz, A., Veldhuizen, E. J. A., Broere, F., Rutten, V. P. M. G., & Jansen, C. A. (2021). The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens. Pathogens, 10(11), 1-20. Article 1512. https://doi.org/10.3390/pathogens10111512
Balhuizen, M. D., van Dijk, A., Jansen, J. W. A., van de Lest, C. H. A., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides. mSphere, 6(4), 1-14. Article e0052321. https://doi.org/10.1128/mSphere.00523-21
van Eijk, M., van Dijk, A., van der Ent, C. K., Arets, H. G. M., Breukink, E., van Os, N., Adrichem, R., van der Water, S., Gomez, R. L., Kristensen, M., Hessing, M., Jekhmane, S., Weingarth, M., Veldhuizen, R. A. W., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections. Biochimica et Biophysica Acta - General Subjects, 1865(9), Article 129951. https://doi.org/10.1016/j.bbagen.2021.129951
Idowu, P. A., Idowu, A. P., Zishiri, O. T., Mpofu, T. J., Veldhuizen, E. J. A., Nephawe, K. A., & Mtileni, B. (2021). Activity of Mannose-Binding Lectin on Bacterial-Infected Chickens-A Review. Animals, 11(3), 1-16. Article 787. https://doi.org/10.3390/ani11030787, https://doi.org/10.3390/ani11030787
Dell'Olmo, E., Gaglione, R., Cesaro, A., Cafaro, V., Teertstra, W. R., de Cock, H., Notomista, E., Haagsman, H. P., Veldhuizen, E. J. A., & Arciello, A. (2021). Host defence peptides identified in human apolipoprotein B as promising antifungal agents. Applied Microbiology and Biotechnology, 105(5), 1953-1964. https://doi.org/10.1007/s00253-021-11114-3
Balhuizen, M. D., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). Outer Membrane Vesicle Induction and Isolation for Vaccine Development. Frontiers in Microbiology, 12, 1-14. Article 629090. https://doi.org/10.3389/fmicb.2021.629090
Balhuizen, M. D., Versluis, C. M., Van Harten, R. M., De Jonge, E. F., Brouwers, J. F., Van De Lest, C. H. A., Veldhuizen, E. J. A., Tommassen, J., & Haagsman, H. P. (2021). PMAP-36 reduces the innate immune response induced by Bordetella bronchiseptica-derived outer membrane vesicles. Current Research in Microbial Sciences, 2, Article 100010. https://doi.org/10.1016/j.crmicr.2020.100010
2020
Scholarly publications
Peng, L., van den Biggelaar, R. H. G. A., Jansen, C. A., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). A method to differentiate chicken monocytes into macrophages with proinflammatory properties. Immunobiology, 225(6), Article 152004. https://doi.org/10.1016/j.imbio.2020.152004
Peng, L., Scheenstra, M. R., van Harten, R. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). The immunomodulatory effect of cathelicidin-B1 on chicken macrophages. Veterinary Research, 51(1), Article 122. https://doi.org/10.1186/s13567-020-00849-y
Scheenstra, M. R., van Harten, R. M., Veldhuizen, E. J. A., Haagsman, H. P., & Coorens, M. (2020). Cathelicidins Modulate TLR-Activation and Inflammation. Frontiers in Immunology, 11, Article 1137. https://doi.org/10.3389/fimmu.2020.01137
Al-Adwani, S., Wallin, C., Balhuizen, M. D., Veldhuizen, E. J. A., Coorens, M., Landreh, M., Végvári, Á., Smith, M. E., Qvarfordt, I., Lindén, A., Gräslund, A., Agerberth, B., & Bergman, P. (2020). Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties. Scientific Reports, 10(1), Article 2376. https://doi.org/10.1038/s41598-020-59071-7
Baer, B., Veldhuizen, E. J. A., Molchanova, N., Jekhmane, S., Weingarth, M., Jenssen, H., Lin, J. S., Barron, A. E., Yamashita, C., & Veldhuizen, R. (2020). Optimizing Exogenous Surfactant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2. Scientific Reports, 10(1), Article 9392. https://doi.org/10.1038/s41598-020-66448-1
Shukla, R., Medeiros-Silva, J., Parmar, A., Vermeulen, B. J. A., Das, S., Paioni, A. L., Jekhmane, S., Lorent, J., Bonvin, A. M. J. J., Baldus, M., Lelli, M., Veldhuizen, E. J. A., Breukink, E., Singh, I., & Weingarth, M. (2020). Mode of action of teixobactins in cellular membranes. Nature Communications, 11(1), 2848. https://doi.org/10.1038/s41467-020-16600-2
Peng, L., Du, W., Balhuizen, M. D., Haagsman, H. P., de Haan, C. A. M., & Veldhuizen, E. J. A. (2020). Antiviral Activity of Chicken Cathelicidin B1 Against Influenza A Virus. Frontiers in Microbiology, 11, Article 426. https://doi.org/10.3389/fmicb.2020.00426
Kraaij, M. D., van Dijk, A., Scheenstra, M. R., van Harten, R. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). Chicken CATH-2 increases antigen presentation markers on chicken monocytes and macrophages. Protein and Peptide Letters, 27(1), 60-66. https://doi.org/10.2174/0929866526666190730125525
https://dspace.library.uu.nl/bitstream/handle/1874/389132/Kraaij_et_al_revised.docx?sequence=3
https://dspace.library.uu.nl/bitstream/handle/1874/389132/Kraaij_et_al_revised.docx?sequence=3
2019
Scholarly publications
Gaglione, R., Cesaro, A., Dell'Olmo, E., Della Ventura, B., Casillo, A., Di Girolamo, R., Velotta, R., Notomista, E., Veldhuizen, E. J. A., Corsaro, M. M., De Rosa, C., & Arciello, A. (2019). Effects of human antimicrobial cryptides identified in apolipoprotein B depend on specific features of bacterial strains. Scientific Reports, 9(1), Article 6728 . https://doi.org/10.1038/s41598-019-43063-3
Mol, N., Peng, L., Esnault, E., Quéré, P., Haagsman, H. P., & Veldhuizen, E. J. A. (2019). Avian pathogenic Escherichia coli infection of a chicken lung epithelial cell line. Veterinary Immunology and Immunopathology, 210, 55-59. https://doi.org/10.1016/j.vetimm.2019.03.007
Scheenstra, M. R., van den Belt, M., Tjeerdsma-van Bokhoven, J. L. M., Schneider, V. A. F., Ordonez, S. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2019). Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Scientific Reports, 9(1), 4780. https://doi.org/10.1038/s41598-019-41246-6
Ordonez, S. R., van Eijk, M., Escobar Salazar, N., de Cock, H., Veldhuizen, E. J. A., & Haagsman, H. P. (2019). Antifungal activities of surfactant protein D in an environment closely mimicking the lung lining. Molecular Immunology, 105, 260-269. https://doi.org/10.1016/j.molimm.2018.12.003
2018
Scholarly publications
Baer, B., Veldhuizen, E. J. A., Possmayer, F., Yamashita, C., & Veldhuizen, R. (2018). The wet bridge transfer system: a novel tool to assess exogenous surfactant as a vehicle for intrapulmonary drug delivery. Discovery medicine, 26(144), 207-218.
Chermprapai, S., Broere, F., Schlotter, Y. M., Veldhuizen, E. J. A., & Rutten, V. P. M. G. (2018). A canine keratinocyte cell line expresses antimicrobial peptide and cytokine genes upon stimulation with bacteria, microbial ligands and recombinant cytokines. Veterinary Immunology and Immunopathology, 206, 35-40. https://doi.org/10.1016/j.vetimm.2018.11.009
Chen, H., Wubbolts, R. W., Haagsman, H. P., & Veldhuizen, E. J. A. (2018). Inhibition and Eradication of Pseudomonas aeruginosa Biofilms by Host Defence Peptides. Scientific Reports, 8(1), Article 10446. https://doi.org/10.1038/s41598-018-28842-8
Peng, L., Matthijs, M. G. R., Haagsman, H. P., & Veldhuizen, E. J. A. (2018). Avian pathogenic Escherichia coli-induced activation of chicken macrophage HD11 cells. Developmental and Comparative Immunology, 87, 75-83. https://doi.org/10.1016/j.dci.2018.05.019
Gao, J., Scheenstra, M. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2018). A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages. Veterinary Immunology and Immunopathology, 200, 7-15. https://doi.org/10.1016/j.vetimm.2018.04.002
2017
Scholarly publications
Bosso, A., Pirone, L., Gaglione, R., Pane, K., Del Gatto, A., Zaccaro, L., Di Gaetano, S., Diana, D., Fattorusso, R., Pedone, E., Cafaro, V., Haagsman, H. P., van Dijk, A., Scheenstra, M. R., Zanfardino, A., Crescenzi, O., Arciello, A., Varcamonti, M., Veldhuizen, E. J. A., ... Pizzo, E. (2017). A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence. Biochimica et Biophysica Acta - General Subjects, 1861(9), 2342-2353. https://doi.org/10.1016/j.bbagen.2017.04.009
Zhang, W., Bouwman, K. M., van Beurden, S. J., Ordonez, S. R., van Eijk, M., Haagsman, H. P., Verheije, M. H., & Veldhuizen, E. J. A. (2017). Chicken mannose binding lectin has antiviral activity towards infectious bronchitis virus. Virology, 509, 252-259. https://doi.org/10.1016/j.virol.2017.06.028
Coorens, M., Schneider, V. A. F., de Groot, A. M., van Dijk, A., Meijerink, M., Wells, J. M., Scheenstra, M. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner. Journal of Immunology, 199(4), 1418-1428. https://doi.org/10.4049/jimmunol.1602164
Coorens, M., Banaschewski, B. J. H., Baer, B. J., Yamashita, C. M., van Dijk, A., Haagsman, H. P., Veldhuizen, R. A. W., & Veldhuizen, E. J. A. (2017). Killing of Pseudomonas aeruginosa by chicken cathelicidin-2 is immunogenically silent, preventing lung inflammation in vivo. Infection and Immunity, 58(12), Article e00546-17. https://doi.org/10.1128/IAI.00546-17
Schneider, V. A. F., Coorens, M., Tjeerdsma-van Bokhoven, J. L. M., Posthuma, G., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response. mSphere, 2(6), Article e00370-17. https://doi.org/10.1128/mSphere.00370-17
Banaschewski, B. J. H., Baer, B., Arsenault, C., Jazey, T., Veldhuizen, E. J. A., Delport, J., Gooyers, T., Lewis, J. F., Haagsman, H. P., Veldhuizen, R. A. W., & Yamashita, C. M. (2017). The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens. Scientific Reports, 7(1), Article 15545. https://doi.org/10.1038/s41598-017-15558-4
Ordonez, S. R., Veldhuizen, E. J. A., van Eijk, M., & Haagsman, H. P. (2017). Role of Soluble Innate Effector Molecules in Pulmonary Defense against Fungal Pathogens. Frontiers in Microbiology, 8, Article 2098. https://doi.org/10.3389/fmicb.2017.02098
Veldhuizen, E. J. A., Scheenstra, M. R., Tjeerdsma-van Bokhoven, J. L. M., Coorens, M., Schneider, V. A. F., Bikker, F. J., van Dijk, A., & Haagsman, H. P. (2017). Antimicrobial and immunomodulatory activity of PMAP-23 derived peptides. Protein and Peptide Letters, 24(7). https://doi.org/10.2174/0929866524666170428150925
Gaglione, R., Dell'Olmo, E., Bosso, A., Chino, M., Pane, K., Ascione, F., Itri, F., Caserta, S., Amoresano, A., Lombardi, A., Haagsman, H. P., Piccoli, R., Pizzo, E., Veldhuizen, E. J. A., Notomista, E., & Arciello, A. (2017). Novel human bioactive peptides identified in apolipoprotein B: evaluation of their therapeutic potential. Biochemical Pharmacology, 130, 34-50. https://doi.org/10.1016/j.bcp.2017.01.009
Coorens, M., Scheenstra, M. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Interspecies cathelicidin comparison reveals divergence in antimicrobial activity, TLR modulation, chemokine induction and regulation of phagocytosis. Scientific Reports, 7, Article 40874. https://doi.org/10.1038/srep40874
Zhang, W., van Eijk, M., Guo, H., van Dijk, A., Bleijerveld, O. B., Verheije, M. H., Wang, G., Haagsman, H. P., & Veldhuizen, E. J. A. (2017). Expression and characterization of recombinant chicken mannose binding lectin. Immunobiology, 222(3), 518-528. https://doi.org/10.1016/j.imbio.2016.10.019
2016
Scholarly publications
Bluhm, M. E. C., Schneider, V. A. F., Schäfer, I., Piantavigna, S., Goldbach, T., Knappe, D., Seibel, P., Martin, L. L., Veldhuizen, E. J. A., & Hoffmann, R. (2016). N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Frontiers in Cell and Developmental Biology, 4(39). https://doi.org/10.3389/fcell.2016.00039
Schneider, V. A. F., Coorens, M., Posthuma, G., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Imaging the antimicrobial mechanism(s) of cathelicidin-2. Scientific Reports, 6, Article 32948. https://doi.org/10.1038/srep32948
Cuperus, T., van Dijk, A., Matthijs, M. G. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli. Scientific Reports, 6, Article 26622. https://doi.org/10.1038/srep26622
Zhang, W., Cuperus, T., van Dijk, A., Skjødt, K., Hansen, S., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Developmental regulation of chicken surfactant protein A and its localization in lung. Developmental and Comparative Immunology, 61, 80-87. https://doi.org/10.1016/j.dci.2016.03.010
Schneider, V. A. F., van Dijk, A., van der Sar, A. M., Kraaij, M. D., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity. Developmental and Comparative Immunology, 60, 108-114. https://doi.org/10.1016/j.dci.2016.02.023
van Dijk, A., van Eldik, M., Veldhuizen, E. J. A., Tjeerdsma-van Bokhoven, H. L. M., de Zoete, M. R., Bikker, F. J., & Haagsman, H. P. (2016). Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides. PLoS One, 11(2), Article e0147919. https://doi.org/10.1371/journal.pone.0147919
2015
Scholarly publications
Coorens, M., van Dijk, A., Bikker, F., Veldhuizen, E. J. A., & Haagsman, H. P. (2015). Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation. Journal of Immunology, 195(8), 3970-3977. https://doi.org/10.4049/jimmunol.1501242
Banaschewski, B. J. H., Veldhuizen, E. J. A., Keating, E., Haagsman, H. P., Zuo, Y. Y., Yamashita, C. M., & Veldhuizen, R. A. W. (2015). Antimicrobial and Biophysical Properties of Surfactant Supplemented with an Antimicrobial Peptide for Treatment of Bacterial Pneumonia. Antimicrobial Agents and Chemotherapy, 59(6), 3075-3083. https://doi.org/10.1128/AAC.04937-14
Other output
Haagsman, H. P., van Dijk, A., & Veldhuizen, E. J. A. (2015). New CATH-2 derivatives. (Patent No. WO2015/170984).
2014
Scholarly publications
Burt, S. A., Ojo-Fakunle, V. T. A., Woertman, J., & Veldhuizen, E. J. A. (2014). The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations. PLoS One, 9(4), Article e93414. https://doi.org/10.1371/journal.pone.0093414
Veldhuizen, E. J. A., Schneider, V. A. F., Agustiandari, H., Van Dijk, A., Tjeerdsma - van Bokhoven, J. L. M., Bikker, F. J., & Haagsman, H. P. (2014). Antimicrobial and immunomodulatory activities of PR-39 derived peptides. PLoS One, 9(4), Article e95939. https://doi.org/10.1371/journal.pone.0095939
Ordonez Alvarez, S., Amarullah, I. H., Wubbolts, R. W., Veldhuizen, E. J. A., & Haagsman, H. P. (2014). Fungicidal mechanisms of cathelicidins LL-37 and CATH-2 revealed by live-cell imaging. Antimicrobial Agents and Chemotherapy, 58(4), 2240-2248. https://doi.org/10.1128/AAC.01670-13
Other output
Haagsman, H., van Dijk, A., & Veldhuizen, E. (Accepted/In press). New CATH-2 derivatives. (Patent No. EP 14167718.7).
2013
Scholarly publications
Veldhuizen, E. J. A., Brouwer, E. C., Schneider, V. A. F., & Fluit, A. C. (2013). Chicken Cathelicidins Display Antimicrobial Activity against Multiresistant Bacteria without Inducing Strong Resistance. PLoS One, 8(4), e61964. https://doi.org/10.1371/journal.pone.0061964
Professional publications
Langeveld, W. T., Veldhuizen, E. J. A., & Burt, S. A. (2013). Positieve interacties tussen vluchtige oliën en antibiotica. Nederlands tijdschrift voor fytotherapie, 26(3), 13-15.
2012
Scholarly publications
van Dijk, A., Herrebout, M., Tersteeg-Zijderveld, M. H. G., Tjeerdsma-van Bokhoven, J. L. M., Bleumink-Pluym, N., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2012). Campylobacter jejuni is highly susceptible to killing by chicken host defense peptide cathelicidin-2 and suppresses intestinal cathelicidin-2 expression in young broilers. Veterinary Microbiology, 160(3-4), 347-354. https://doi.org/10.1016/j.vetmic.2012.05.034
Inamuco, J., Veenendaal, A. K. J., Burt, S. A., Post, J. A., Tjeerdsma-van Bokhoven, J. L. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2012). Sub-lethal levels of carvacrol reduce Salmonella Typhimurium motility and invasion of porcine epithelial cells. Veterinary Microbiology, 157(1-2), 200-207. https://doi.org/10.1016/j.vetmic.2011.12.021
Other output
Bikker, F. J., van Dijk, A., Mars-Groenendijk, R., Veldhuizen, E., van der Kleij, D., Haagsman, H., & Molhoek, E. M. (2012). Antimicrobial peptides based on CMAP27. (Patent No. US-2012-0093844-A1).
2011
Scholarly publications
Veldhuizen, E. J. A., van Eijk, M., & Haagsman, H. P. (2011). The carbohydrate recognition domain of collectins. The FEBS journal, 278, 3930-3941. https://doi.org/10.1111/j.1742-4658.2011.08206.x
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). A cathelicidin-2-derived peptide effectively impairs Staphylococcus epidermidis biofilms. International Journal of Antimicrobial Agents, 37, 476-479. https://doi.org/10.1016/j.ijantimicag.2010.12.020
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization. Peptides, 32(5), 875-880. https://doi.org/10.1016/j.peptides.2011.02.017
Chiang, S. C., Veldhuizen, E. J. A., Barnes, F. A., Craven, C. J., Haagsman, H. P., & Bingle, C. D. (2011). Identification and characterisation of the BPI/LBP/PLUNC-like gene repertoire in chickens reveals the absence of a LBP gene. Developmental and Comparative Immunology, 35, 285-295.
van Dijk, A., Molhoek, E. H., Bikker, F. J., Yu, P. L., Veldhuizen, E. J. A., & Haagsman, H. P. (2011). Avian cathelicidins: Paradigms for the development of anti-infectives. Veterinary Microbiology, 153, 27-36.
2010
Scholarly publications
Orgeig, S., Hiemstra, P. S., Veldhuizen, E. J. A., Casals, C., Clark, H. W., Hackzu, A., Knudsen, L., & Possmayer, F. (2010). Recent advances in alveolar biology: Evolution and function of alveolar proteins. Respiratory physiology & neurobiology, 173(Suppl. 1), S43-S54. https://doi.org/10.1016/j.resp.2010.04.023
Reemers, S. S. N., Veldhuizen, E. J. A., Fleming, C., van Haarlem, D. A., Haagsman, H. P., & Vervelde, L. (2010). Transcriptional expression levels of chicken collectins are effected by avian influenza A virus inoculation. Veterinary Microbiology, 141, 379-384. https://doi.org/10.1016/j.vetmic.2009.09.026
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Dijk-Knijnenburg, H., Mars-Groenendijk, R. H., Boele, L. C., Kaman-van Zanten, W. E., Haagsman, H. P., & Bikker, F. J. (2010). Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents. International Journal of Antimicrobial Agents, 36(3), 271-274. https://doi.org/10.1016/j.ijantimicag.2010.06.001
Professional publications
Veldhuizen, E. J. A. (2010). Pilot study to determine the antibacterial and immunomodulatory effect of chicken cathelicidin 2 in the chicken crop upon Salmonella Enteritidis infection. Schothorst Feed Research.
Other output
Veldhuizen, E. J. A. (2010). New antimicrobial peptides based on CMAP27 in samenwerking met TNO Rijswijk. (Patent No. Patent: P86425PC00).
2009
Scholarly publications
van Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis. Molecular Immunology, 46(13), 2449-55. https://doi.org/10.1016/j.molimm.2009.05.028
Veldhuizen, E. J. A., Koomen, I., Ultee, A., van Dijk, A., & Haagsman, H. P. (2009). Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line. Veterinary Microbiology, 136, 69-75.
Wijnker, J. J., Tjeerdsma - van Bokhoven, J. L. M., & Veldhuizen, E. J. A. (2009). Phosphate analysis of natural sausage casings preserved in brines with phosphate additives as inactivating agent – Method validation. Meat Science, 81, 245-248.
van Dijk, A., Tersteeg-Zijderveld, H. G., Tjeerdsma-van Bokhoven, J. L. M., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2009). Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS. Molecular Immunology, 46, 1517-1526.
Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of -defensins in dogs with atopic dermatitis. Molecular Immunology, 46, 2449-2455.
van Dijk, A., Molhoek, E. M., Veldhuizen, E. J. A., Tjeerdsma - van Bokhoven, H., Wagendorp, E., Bikker, F., & Haagsman, H. P. (2009). Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities. Molecular Immunology, 46, 2465-2473.
2008
Scholarly publications
Haagsman, H. P., Hogenkamp, A., van Eijk, M., & Veldhuizen, E. J. A. (2008). Surfactant collectins and innate immunity. Neonatology, 93, 288-294.
Hogenkamp, A., Isohadouten, N., Reemers, S. S. N., Romijn, R. A., Hemrika, W., White, M. R., Tefsen, B., Vervelde, L., van Eijk, M., Veldhuizen, E. J. A., & Haagsman, H. P. (2008). Chicken lung lectin is a functional C-type lectin and inhibits haemagglutination by influenza A virus. Veterinary Microbiology, 130, 37-46.
Veldhuizen, E. J. A., Rijnders, M., Claassen, E. A., van Dijk, A., & Haagsman, H. P. (2008). Porcine ß-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Molecular Immunology, 45, 386-394.
van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2008). Avian defensins. Veterinary Immunology and Immunopathology, 124, 1-18.
2007
Scholarly publications
Veldhuizen, E. J. A., van Dijk, A., Tersteeg, M. H., Kalkhove, S. I. C., van der Meulen, J., Niewold, T. A., & Haagsman, H. P. (2007). Expression of β-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection. Molecular Immunology, 44(4), 276-283.
https://dspace.library.uu.nl/bitstream/handle/1874/26132/veldhuizen%2520et%2520al%25202007.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/26132/veldhuizen%2520et%2520al%25202007.pdf?sequence=2
Niewold, T. A., Veldhuizen, E. J. A., van der Meulen, J., Haagsman, H. P., de Wit, A. A. C., Smits, M. A., Tersteeg, M. H. G., & Hulst, M. M. (2007). The early transcriptional response of pig small intestinal mucosa to invasion by Salmonella enterica serovar typhimurium DT104. Molecular Immunology, 44(6), 1316-1322. https://doi.org/10.1016/j.molimm.2006.05.013
Veldhuizen, E. J. A., Creutzberg, T. O., Burt, S. A., & Haagsman, H. P. (2007). Low temperature and binding to food components inhibit the antibacterial activity of carvacrol against Listeria monocytogenes in steak tartare. Journal of Food Protection, 70(9), 2127-2132. https://doi.org/10.4315/0362-028X-70.9.2127
van Dijk, A., Veldhuizen, E. J. A., Kalkhove, S. I. C., Tjeerdsma-van Bokhoven, J. L. M., Romijn, R. A., & Haagsman, H. P. (2007). The β-defensin gallinacin-6 is expressed in the chicken digestive tract and has antimicrobial activity against food-borne pathogens. Antimicrobial Agents and Chemotherapy, 51(3), 912-922.
https://dspace.library.uu.nl/bitstream/handle/1874/309938/van_Dijk_et_al_2007.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/309938/van_Dijk_et_al_2007.pdf?sequence=1
Burt, S. A., van der Zee, R., Koets, A. P., de Graaff, A. M., van Knapen, F., Gaastra, W., Haagsman, H. P., & Veldhuizen, E. J. A. (2007). Carvacrol induces heat shock protein 60 and inhibits synthesis of flagellin in Escherichia coli O157:H7. Applied and Environmental Microbiology, 73(14), 4484-4490. https://doi.org/10.1128/AEM.00340-07
Burt, S. A., Fledderman, M. J., Haagsman, H. P., van Knapen, F., & Veldhuizen, E. J. A. (2007). Inhibition of salmonella enterica serotype enteriditis on agar and raw chicken by carvacrol vapour. International Journal of Food Microbiology, 119(3), 346-350. https://doi.org/10.1016/j.ijfoodmicro.2007.05.002
Hogenkamp, A., Herías, M. V., Tooten, P. C. J., Veldhuizen, E. J. A., & Haagsman, H. P. (2007). Effects of surfactant protein D on growth, adhesion and epithelial invasion of intestinal Gram-negative bacteria. Molecular Immunology, 44(14), 3517-27. https://doi.org/10.1016/j.molimm.2007.03.013
2006
Scholarly publications
Hogenkamp, A., van Eijk, M., van Dijk, A., van Asten, A. J., Veldhuizen, E. J. A., & Haagsman, H. P. (2006). Characterization and expression sites of newly identified chicken collectins. Molecular Immunology, 43(10), 1604-1606.
Veldhuizen, E. J. A., Hendriks, H. G. C. J. M., Hogenkamp, A., van Dijk, A., Gaastra, W., Tooten, P. C. J., & Haagsman, H. P. (2006). Differential regulation of porcine beta-defensins 1 and 2 upon Salmonella infection in the intestinal epithelial cell line IPI-2I. Veterinary Immunology and Immunopathology, 114(1-2), 94-102. https://doi.org/10.1016/j.vetimm.2006.07.012
Veldhuizen, E. J. A., Tjeerdsma - van Bokhoven, J. L. M., Zweijtzer, C., Burt, S. A., & Haagsman, H. P. (2006). Structural requirements for the antimicrobial activity of carvacrol. Journal of Agricultural and Food Chemistry, 54(5), 1874-1879.
2005
Scholarly publications
van Dijk, A., Veldhuizen, E. J. A., van Asten, A. J. A. M., & Haagsman, H. P. (2005). CMAP27, a novel chicken cathelicidin-like antimicrobial protein. Veterinary Immunology and Immunopathology, 106, 321-327.
Veldhuizen, E. J. A., Vaillancourt, F. H., Whiting, C. J., -Y. Hsiao, M. M., Gingras, G., Xiao, Y., Tanguay, R. M., Boukouvalas, J., & Eltis, L. D. (2005). Steady-state kinetics and inhibition of anaerobically purified human homogentisate 1,2-dioxygenase. Biochemical Journal, 386, 305-314.
Burt, S. A., Vlielander, R., Haagsman, H. P., & Veldhuizen, E. J. A. (2005). Increase in activity of essential oil components carvacrol and thymol against escherichia coli 0157:H7 by addition of food stabilizers. Journal of Food Protection, 68(5), 919-926.
2001
Scholarly publications
Veldhuizen, E. J. A., Diemel, R. V., Putz, G., van Golde, L. M. G., Batenburg, J. J., & Haagsman, H. P. (2001). Effect of the hydropholic surfactant proteins on the surface activity of spread films in captive bubble surfactometer. Chemistry and Physics of Lipids, 110, 47-55.
2000
Scholarly publications
Veldhuizen, E. J. A., & Haagsman, H. P. (2000). Role of pulmonary surfactant components in surface film formation dynamics. Biochimica et Biophysica Acta, 1467, 255-270.
Veldhuizen, E. J. A. (2000). Surface activity of pulmonary surfactant proteins. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University].
Veldhuizen, E. J. A., Batenburg, J. J., van Golde, L. M. G., & Haagsman, H. P. (2000). The role of surfactant proteins in DPPC enrichment of surface films. Biophysical Journal, 79, 3164-3171.
Veldhuizen, E. J. A., Waring, A. J., Walther, F. J., Batenburg, J. J., van Golde, L. M. G., & Haagsman, H. P. (2000). Dimeric N-terminal segment of human surfactant protein B (dSP-B1-25) has enhanced surface properties compared to monomeric SP- B1-25. Biophysical Journal, 79, 377-384.
1999
Scholarly publications
Veldhuizen, E. J., Batenburg, J. J., Vandenbussche, G., Putz, G., van Golde, L. M., & Haagsman, H. P. (1999). Production of surfactant protein C in the baculovirus expression system: the information required for correct folding and palmitoylation of SP-C is contained within the mature sequence. Biochimica et Biophysica Acta, 1416(1-2), 295-308.
1998
Scholarly publications
Nilsson, G., Gustafsson, M., Vandenbussche, G., Veldhuizen, E., Griffiths, W. J., Sjövall, J., Haagsman, H. P., Ruysschaert, J. M., Robertson, B., Curstedt, T., & Johansson, J. (1998). Synthetic peptide-containing surfactants--evaluation of transmembrane versus amphipathic helices and surfactant protein C poly-valyl to poly-leucyl substitution. European Journal of Biochemistry, 255(1), 116-24.
1993
Scholarly publications
Lugtigheid, R. B., Nicolaes, G. A., Veldhuizen, E. J., Slotboom, A. J., Verheij, H. M., & De Haas, G. H. (1993). Acylation of porcine pancreatic phospholipase A2 influences penetration and substrate head-group binding, depending on the position of the acylated lysine in the enzyme molecule. European Journal of Biochemistry, 216(2), 519-25.