Publications
2024
Scholarly publications
Westendorp, B. (2024). A reverse brake for the cell cycle. Science (New York, N.Y.), 384(6695), 512-513. https://doi.org/10.1126/science.adp1866
Yetkin-Arik, B., Jansen, S. A., Varderidou-Minasian, S., Westendorp, B., Skarp, K.-P., Altelaar, M., Lindemans, C. A., & Lorenowicz, M. J. (2024). Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damage. Stem cell research & therapy, 15(1), Article 125. https://doi.org/10.1186/s13287-024-03738-9
https://dspace.library.uu.nl/bitstream/handle/1874/451868/s13287-024-03738-9.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/451868/s13287-024-03738-9.pdf?sequence=1
Segeren, H. A., Wierenga, K. A., Riemers, F. M., Liere, E. A. V., & Westendorp, B. (2024). Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance. bioRxiv. https://doi.org/10.1101/2024.03.26.585806
https://dspace.library.uu.nl/bitstream/handle/1874/437461/2024.03.26.585806v1.full.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/437461/2024.03.26.585806v1.full.pdf?sequence=1
Veth, T. S., Nouwen, L. V., Zwaagstra, M., Lyoo, H., Wierenga, K. A., Westendorp, B., Altelaar, M. A. F. M., Berkers, C., van Kuppeveld, F. J. M., & Heck, A. J. R. (2024). Assessment of Kinome-wide Activity Remodeling Upon Picornavirus Infection. Molecular and Cellular Proteomics, 23(5), Article 100757. https://doi.org/10.1016/j.mcpro.2024.100757
Segui-Perez, C., Stapels, D. A. C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wubbolts, R. W., Wu, W., van Putten, J. P. M., & Strijbis, K. (2024). MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C. Journal of Cell Science, 137(5). https://doi.org/10.1242/jcs.261468
2023
Scholarly publications
Iglesias-Ara, A., & Westendorp, B. (2023). Editorial: The role of E2F transcription factors in cancer. Frontiers in Oncology, 13, 1-2. Article 1355610. https://doi.org/10.3389/fonc.2023.1355610
https://dspace.library.uu.nl/bitstream/handle/1874/435667/fonc-13-1355610.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/435667/fonc-13-1355610.pdf?sequence=1
Thijssen, B., Segeren, H. A., Liu, Q., Wessels, L. F. A., & Westendorp, B. (2023). Inferring single-cell protein levels and cell cycle behavior in heterogeneous cell populations. (pp. 1-27). bioRxiv. https://doi.org/10.1101/2023.08.24.554605
Chatterjee, M., Huang, L. Z. X., Mykytyn, A. Z., Wang, C., Lamers, M. M., Westendorp, B., Wubbolts, R. W., van Putten, J. P. M., Bosch, B.-J., Haagmans, B. L., & Strijbis, K. (2023). Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface. PLoS Pathogens, 19(8), Article e1011571. https://doi.org/10.1371/journal.ppat.1011571
2022
Scholarly publications
Wierenga, K. A., Riemers, F. M., Westendorp, B., Harkema, J. R., & Pestka, J. J. (2022). Single cell analysis of docosahexaenoic acid suppression of sequential LPS-induced proinflammatory and interferon-regulated gene expression in the macrophage. Frontiers in Immunology, 13, Article 993614. https://doi.org/10.3389/fimmu.2022.993614
Segui-Perez, C., Stapels, D. A. C., Ma, Z., Su, J., Passchier, E., Westendorp, B., Wu, W., Putten, J. P. M. V., & Strijbis, K. (2022). MUC13 negatively regulates tight junction proteins and intestinal epithelial barrier integrity via Protein Kinase C. (pp. 1-30). bioRxiv. https://doi.org/10.1101/2022.10.27.513982
Moreno, E., Matondo, A. B., Bongiovanni, L., van de Lest, C. H. A., Molenaar, M. R., Toussaint, M. J. M., van Essen, S. C., Houweling, M., Helms, J. B., Westendorp, B., & de Bruin, A. (2022). Inhibition of polyploidization in Pten-deficient livers reduces steatosis. Liver International, 42(11), 2442-2452. https://doi.org/10.1111/liv.15384
Segeren, H. A., & Westendorp, B. (2022). Mechanisms used by cancer cells to tolerate drug-induced replication stress. Cancer Letters, 544, 1-10. Article 215804. https://doi.org/10.1016/j.canlet.2022.215804
Segeren, H. A., van Liere, E. A., Riemers, F. M., de Bruin, A., & Westendorp, B. (2022). Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53. Oncogene, 41(19), 2719-2733. https://doi.org/10.1038/s41388-022-02291-0
Andriessen, A., Bongiovanni, L., Driedonks, T. A. P., van Liere, E., Seijger, A., Hegeman, C. V., van Nimwegen, S. A., Galac, S., Westendorp, B., Nolte-T Hoen, E. N. M., & de Bruin, A. (2022). CDC6: A novel canine tumour biomarker detected in circulating extracellular vesicles. Veterinary and Comparative Oncology, 20(2), 381-392. https://doi.org/10.1111/vco.12781
Other output
Westendorp, B. (2022). The RAS oncogene hits the brake pedal on P53. Web publication/site, Nature Research. https://cancercommunity.nature.com/posts/the-ras-oncogene-hits-the-brake-pedal-on-p53
2021
Scholarly publications
Chatterjee, M., Huang, L. Z. X., Wang, C., Mykytyn, A. Z., Westendorp, B., Wubbolts, R. W., Bosch, B.-J., Haagmans, B. L., Putten, J. P. M. V., & Strijbis, K. (2021). The glycosylated extracellular domain of MUC1 protects against SARS-CoV-2 infection at the respiratory surface. bioRxiv. https://doi.org/10.1101/2021.10.29.466408
Roukens, M. G., Frederiks, C. L., Seinstra, D., Braccioli, L., Khalil, A. A., Pals, C., De Neck, S., Bornes, L., Beerling, E., Mokry, M., de Bruin, A., Westendorp, B., van Rheenen, J., & Coffer, P. J. (2021). Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation. Oncogene, 40(45), 6343-6353. https://doi.org/10.1038/s41388-021-02004-z
Segeren, H. A., Andree, K. C., Oomens, L., & Westendorp, B. (2021). Collection of cells for single-cell RNA sequencing using high-resolution fluorescence microscopy. STAR Protocols, 2(3), 1-11. Article 100718. https://doi.org/10.1016/j.xpro.2021.100718
Moreno, E., Pandit, S. K., Toussaint, M. J. M., Bongiovanni, L., Harkema, L., van Essen, S. C., van Liere, E. A., Westendorp, B., & de Bruin, A. (2021). Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context. Cancers, 13(9), 1-14. Article 2033. https://doi.org/10.3390/cancers13092033
Moreno, E., Toussaint, M. J. M., van Essen, S. C., Bongiovanni, L., van Liere, E. A., Koster, M. H., Yuan, R., van Deursen, J., Westendorp, B., & de Bruin, A. (2021). E2F7 is a potent inhibitor of liver tumor growth in adult mice. Hepatology, 73(1), 303-317. https://doi.org/10.1002/hep.31259
2020
Scholarly publications
Segeren, H. A., van Rijnberk, L., Moreno, E., Riemers, F., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell Cycle Exit after DNA Damage. SSRN. https://doi.org/10.2139/ssrn.3570558
Segeren, H. A., van Rijnberk, L. M., Moreno, E., Riemers, F. M., van Liere, E. A., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage. Cell Reports, 33(9), Article 108449. https://doi.org/10.1016/j.celrep.2020.108449
Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C. J., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N., & Villunger, A. (2020). PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Reports, 21, 1-16. Article e50893. https://doi.org/10.15252/embr.202050893
Sladky, V. C., Knapp, K., Soratroi, C., Heppke, J., Eichin, F., Rocamora-Reverte, L., Szabo, T. G., Bongiovanni, L., Westendorp, B., Moreno, E., van Liere, E. A., Bakker, B., Spierings, D. C. J., Wardenaar, R., Pereyra, D., Starlinger, P., Schultze, S., Trauner, M., Stojakovic, T., ... Villunger, A. (2020). E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration. Developmental Cell, 52(3), 335-349.e7. https://doi.org/10.1016/j.devcel.2019.12.016
2019
Scholarly publications
Yuan, R., Liu, Q., Segeren, H. A., Yuniati, L., Guardavaccaro, D., Lebbink, R. J., Westendorp, B., & de Bruin, A. (2019). Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression. EMBO Journal, 38, Article e101430. https://doi.org/10.15252/embj.2018101430
2018
Scholarly publications
Kruitwagen, H. S., Westendorp, B., Viebahn, C. S., Post, K., van Wolferen, M. E., Oosterhoff, L. A., Egan, D. A., Delabar, J.-M., Toussaint, M. J., Schotanus, B. A., de Bruin, A., Rothuizen, J., Penning, L. C., & Spee, B. (2018). DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells. Stem Cells and Development, 27(2), 133-146. https://doi.org/10.1089/scd.2017.0139
Segeren, H. A., de Bruin, A., & Westendorp, B. (2018). A single cell approach to explore replication stress tolerance in cancer cells as therapeutic target..
Yuan, R., Vos, H., van Es, R. M., Chen, J., Burgering, B. M. T., Westendorp, B., & de Bruin, A. (2018). Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest. EMBO Journal, 37(5), Article e97877. https://doi.org/10.15252/embj.201797877
Weijts, B. G. M. W., Westendorp, B., Hien, B. T., Martínez-López, L. M., Zijp, M., Thurlings, I., Thomas, R. E., Schulte-Merker, S., Bakker, W. J., & de Bruin, A. (2018). Atypical E2Fs inhibit tumor angiogenesis. Oncogene, 37, 271-276. https://doi.org/10.1038/onc.2017.336
Popularising publications
Westendorp, B. (2018, Oct 28). Kanker bij dieren: hoe voelt een tumor?
2017
Scholarly publications
Kent, L. N., Bae, S., Tsai, S. Y., Tang, X., Srivastava, A., Koivisto, C., Martin, C. K., Ridolfi, E., Miller, G. C., Zorko, S. M., Plevris, E., Hadjiyannis, Y., Perez, M., Nolan, E., Kladney, R., Westendorp, B., De Bruin, A., Fernandez, S., Rosol, T. J., ... Leone, G. (2017). Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. Journal of Clinical Investigation, 127(3), 830-842. https://doi.org/10.1172/JCI87583
Thurlings, I., Martínez-López, L. M., Westendorp, B., Zijp, M., Kuiper, R., Tooten, P., Kent, L. N., Leone, G., Vos, H. J., Burgering, B., & de Bruin, A. (2017). Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. Oncogene, 36, 829-839. https://doi.org/10.1038/onc.2016.251
2016
Scholarly publications
Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H. Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., Koivisto, C., Martin, C. K., Cuitino, M. C., Perez, M., Clouse, J. M., Chokshi, V., Shinde, N., Kladney, R., Sun, D., ... Leone, G. (2016). E2f8 mediates tumor suppression in postnatal liver development. Journal of Clinical Investigation, 126(8), 2955-2969. https://doi.org/10.1172/JCI85506
Boekhout, M., Yuan, R., Wondergem, A. P., Segeren, H. A., Van Liere, E. A., Awol, N., Jansen, I., Wolthuis, R. M., De Bruin, A., & Westendorp, B. (2016). Feedback regulation between atypical E2Fs and APC/C Cdh1 coordinates cell cycle progression. EMBO Reports, 17(3), 414-427. https://doi.org/10.15252/embr.201540984
2013
Scholarly publications
Pandit, S. K., Westendorp, B., & de Bruin, A. (2013). Physiological significance of polyploidization in mammalian cells. Trends in Cell Biology, 23(11), 556-566. https://doi.org/10.1016/j.tcb.2013.06.002
Bakker, W. J., Weijts, B. G. M. W., Westendorp, B., & de Bruin, A. (2013). HIF proteins connect the RB-E2F factors to angiogenesis. Transcription, 4, 62-66. https://doi.org/10.4161/trns.23680
2012
Scholarly publications
Nader, M., Westendorp, B., Hawari, O., Salih, M., Stewart, AF., Leenen, FH., & Tuana, BS. (2012). Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum. American journal of physiology. Heart and circulatory physiology, 302(5), H1138-H1145. https://doi.org/10.1152/ajpheart.00872.2011
Weijts, B. G. M. W., Bakker, W. J., Cornelissen, P. W. A., Liang, K. A., Schaftenaar, F. A., Westendorp, B., Wolf, C. A., Paciejewska, M., Scheele, C. L., Kent, L., Leone, G., Schulte-Merker, S., & de Bruin, A. (2012). E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO Journal, 19, 3871-3884. https://doi.org/10.1038/emboj.2012.231
Pandit, S. K., Westendorp, B., Nantasanti, S., van Liere, E., Tooten, P. C. J., Cornelissen, P. W. A., Toussaint, M. J. M., Lamers, W. H., & de Bruin, A. (2012). E2F8 is essential for polyploidization in mammalian cells. Nature Cell Biology, 14(11), 1181-1191. https://doi.org/10.1038/ncb2585
Westendorp, B., Major, J. L., Nader, M., Salih, M., Leenen, F. H., & Tuana, B. S. (2012). The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy. FASEB Journal, 26(6), 2569-2579. https://doi.org/10.1096/fj.11-203174
Westendorp, B., Mokry, M., Groot Koerkamp, M. J., Holstege, F. C. P., Cuppen, E. P. J. G., & de Bruin, A. (2012). E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Research, 40(8), 3511-3523. https://doi.org/10.1093/nar/gkr1203
https://dspace.library.uu.nl/bitstream/handle/1874/281319/Westendorp_NuclAcidsRes2012_40_3511_23.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/281319/Westendorp_NuclAcidsRes2012_40_3511_23.pdf?sequence=1