prof. dr. B.P. (Bjorn) Meij
Gegenereerd op 2017-11-20 07:08:31


Chair
Chirurgie van Gezelschapsdieren
Gegenereerd op 2017-11-20 07:08:31
All publications
  Articles - 2017
Bach, Frances, Miranda-Bedate, Alberto, van Heel, Ferdi, Riemers, Frank, Muller, Margot, Creemers, Laura, Ito, Keita, Benz, Karin, Meij, Björn & Tryfonidou, M (01.03.2017). Bone morphogenetic protein-2, but not mesenchymal stromal cells, exert regenerative effects on canine and human nucleus pulposus cells. Tissue Engineering - Part A., 23 (5-6), (pp. 233-242).
Teunissen, M, van der Veen, A J, Smit, T H, Tryfonidou, M A & Meij, B P (2017). Effect of a titanium cage as a stand-alone device on biomechanical stability in the lumbosacral spine of canine cadavers. Veterinary Journal, 220, (pp. 17-23) (7 p.). Copyright © 2016 Elsevier Ltd. All rights reserved..
Teunissen, Michelle, M Riemers, Frank, van Leenen, Dik, J A Groot Koerkamp, Marian, P Meij, Björn, Alblas, Jacqueline, C Penning, Louis, Miranda-Bedate, Alberto & A Tryfonidou, Marianna (06.07.2017). Growth Plate Expression profiling - Large and Small Breed Dogs Provide New Insights in Endochondral Bone Formation. Journal of Orthopaedic Research This article is protected by copyright. All rights reserved..
Tellegen, Anna R, Willems, Nicole, Beukers, Martijn, Grinwis, Guy C M, Plomp, Saskia G M, Bos, Clemens, van Dijk, Maarten, de Leeuw, Mike, Creemers, Laura B, Tryfonidou, Marianna A & Meij, Björn P (2017). Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines - what's in it for humans?. Journal of Tissue Engineering and Regenerative Medicine This article is protected by copyright. All rights reserved..
Hansen, Tove, Smolders, Lucas A, Tryfonidou, Marianna A, Meij, Björn P, Vernooij, Johannes C M, Bergknut, Niklas & Grinwis, Guy C M (01.01.2017). The Myth of Fibroid Degeneration in the Canine Intervertebral Disc - A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs. Veterinary Pathology, (pp. 300985817726834).
  Articles - 2016
Del Magno, Sara, Grinwis, Guy C M, Voorhout, George & Meij, Björn P. (2016). Dynamic computed tomography of the pituitary gland using a single slice scanner in dogs with pituitary-dependent hypercortisolism. Research in Veterinary Science, 107, (pp. 42-49) (8 p.).
Bach, Frances C, Zhang, Ying, Miranda-Bedate, Alberto, Verdonschot, Lucy C, Bergknut, Niklas, Creemers, Laura B, Ito, Keita, Sakai, Daisuke, Chan, Danny, Meij, Björn P & Tryfonidou, Marianna A (2016). Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Research and Therapy, 18 (59).
Willems, Nicole, Tellegen, Anna R, Bergknut, Niklas, Creemers, Laura B, Wolfswinkel, Jeannette, Freudigmann, Christian, Benz, Karin, Grinwis, Guy C M, Tryfonidou, Marianna A & Meij, Björn P (13.01.2016). Inflammatory profiles in canine intervertebral disc degeneration. BMC Veterinary Research, 12 (10).
Tellegen, A R, Beukers, M, Miranda-Bedate, A, Grinwis, G C, Creemers, Laura B, Van Dijk, M, De Leeuw, M, Tryfonidou, M A & Meij, B P (2016). Intradiscal injection of a slow release formulation of celecoxib for the treatment of dogs with low back pain. Osteoarthritis and Cartilage, 24, (pp. S480).
Sbiera, Silviu, Tryfonidou, Marianna A, Weigand, Isabel, Grinwis, Guy C M, Broeckx, Bart, Herterich, Sabine, Allolio, Bruno, Deutschbein, Timo, Fassnacht, Martin & Meij, Björn P (22.12.2016). Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas. PLoS One, 11 (12).
Bach, F C, de Vries, S A, Riemers, F M, Boere, J, van Heel, F W, van Doeselaar, M, Goerdaya, S S, Nikkels, P G, Benz, K, Creemers, L B, Maarten Altelaar, A F, Meij, B P, Ito, K & Tryfonidou, M A (2016). Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium - implications for IVD regeneration. European Cells and Materials, 32, (pp. 163-80) (18 p.).
van Rijn, Sarah, Galac, S., Tryfonidou, M. A., Hesselink, J. W., Penning, L. C., Kooistra, H. S. & Meij, B. P. (01.07.2016). The Influence of Pituitary Size on Outcome After Transsphenoidal Hypophysectomy in a Large Cohort of Dogs with Pituitary-Dependent Hypercortisolism. Journal of Veterinary Internal Medicine, 30 (4), (pp. 989-995) (7 p.).
  Articles - 2015
Voorbij, A. M W Y, Meij, B. P., van Bruggen, L. W L, Grinwis, G. C M, Stassen, Q. E M & Kooistra, H. S. (01.01.2015). Atlanto-Axial Malformation and Instability in Dogs with Pituitary Dwarfism due to an LHX3 Mutation. Journal of Veterinary Internal Medicine, 29 (1), (pp. 207-213) (7 p.).
Willems, Nicole, Yang, Hsiao-Yin, Langelaan, Marloes L P, Tellegen, Anna R, Grinwis, Guy C M, Kranenburg, Hendrik-Jan C, Riemers, Frank M, Plomp, Saskia G M, Craenmehr, Eric G M, Dhert, Wouter J A, Papen-Botterhuis, Nicole E, Meij, Björn P, Creemers, Laura B & Tryfonidou, Marianna (2015). Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model. Arthritis Research and Therapy, 17 (1), (pp. 214).
de Vries, Stefan A H, Potier, Esther, van Doeselaar, Marina, Meij, Björn P, Tryfonidou, Marianna A & Ito, Keita (2015). Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells. Tissue Engineering - Part A., 21 (5-6), (pp. 1077-1084) (8 p.).
Arkesteijn, Irene Tm, Smolders, Lucas A, Spillekom, Sandra, Riemers, Frank M, Potier, Esther, Meij, Björn P, Ito, Keita & Tryfonidou, Marianna A (2015). Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration. Arthritis Research and Therapy, 17 (1).
van Rijn, Sarah J, Pouwer, Marianne G, Tryfonidou, Marianna A, Grinwis, Guy C M, van der Bend, Joanne E E, Beukers, Pauline E P F, Vastenhout, Nadie, Drouin, Jacques, Penning, Louis C & Meij, Björn P (15.04.2015). Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. Veterinary Journal, 204 (3), (pp. 315-321) (7 p.). Copyright © 2015 Elsevier Ltd. All rights reserved..
Manunta, M L, Evangelisti, M A, Bergknut, N, Grinwis, G C M, Ballocco, I & Meij, B P (30.03.2015). Hydrated nucleus pulposus herniation in seven dogs. Veterinary Journal, 203 (3), (pp. 342-344). Copyright © 2014 Elsevier Ltd. All rights reserved..
Willems, Nicole, Bach, Frances C, Plomp, Saskia G M, van Rijen, Mattie Hp, Wolfswinkel, Jeannette, Grinwis, Guy Cm, Bos, Clemens, Strijkers, Gustav J, Dhert, Wouter Ja, Meij, Björn P, Creemers, Laura B & Tryfonidou, Marianna A (2015). Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration. Arthritis Research and Therapy, 17, (pp. 1-14) (14 p.).
Tellegen, Anna R, Willems, Nicole, Tryfonidou, Marianna A & Meij, Björn P (2015). Pedicle screw-rod fixation - a feasible treatment for dogs with severe degenerative lumbosacral stenosis. BMC Veterinary Research, 11 (1) (13 p.).
Willems, Nicole, Mihov, George, Grinwis, Guy C M, van Dijk, Maarten, Schumann, Detlef, Bos, Clemens, Strijkers, Gustav J, Dhert, Wouter J A, Meij, Björn P, Creemers, Laura B & Tryfonidou, Marianna A (21.12.2015). Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration. Journal of Biomedical Materials Research - Part B Applied Biomaterials © 2015 Wiley Periodicals, Inc..
Antoniou, John, Wang, Hong Tian, Hadjab, Insaf, Aldebeyan, Sultan, Alaqeel, Motaz A, Meij, Björn P, Tryfonidou, Marianna A & Mwale, Fackson (2015). The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells. Tissue Engineering - Part A., 21 (13-14), (pp. 2136-2146) (11 p.).
van Rijn, S J, Hanson, J M, Zierikzee, D, Kooistra, H S, Penning, L C, Tryfonidou, M A & Meij, B P (2015). The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas. Journal of Veterinary Internal Medicine, 29 (3), (pp. 869-876) (8 p.). Copyright © 2015 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine..
Bach, F C, de Vries, S A, Krouwels, A, Creemers, L B, Ito, K, Meij, B P & Tryfonidou, M A (2015). The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs. European Cells and Materials, 30, (pp. 132-147) (16 p.).
  Articles - 2014
Fracassi, F., Mandrioli, L., Shehdula, D., Diana, A., Grinwis, G.C.M. & Meij, B.P. (2014). Complete surgical removal of a very enlarged pituitary corticotroph adenoma in a dog. Journal of the American Animal Hospital Association, 50 (3), (pp. 192-197) (6 p.).
van Rijn, Sarah J, Riemers, Frank M, van den Heuvel, Douwe, Wolfswinkel, Jeannette, Hofland, Leo, Meij, Björn P & Penning, Louis C (2014). Expression stability of reference genes for quantitative RT-PCR of healthy and diseased pituitary tissue samples varies between humans, mice, and dogs. Molecular Neurobiology, 49 (2), (pp. 893-899) (7 p.).
Krauss, M.W., Benato, L., McDonnell, J., Schoemaker, N.J., Westerhof, I., Bronson, E., Gielen, I., van Caelenberg, A., Hellebuyck, T., Meij, B.P. & de Decker, S. (2014). Intervertebral Disk Disease in 3 Striped Skunks (Mephitis mephitis). Veterinary Surgery, 43 (5), (pp. 589–592).
Kranenburg, H.C., Hazewinkel, H.A.W. & Meij, B.P. (2014). Naturally Occurring Spinal Hyperostosis in Dogs as a Model for Human Spinal Disorders. ILAR Journal, 55 (1), (pp. 150-163) (14 p.).
Bach, Frances C, Willems, Nicole, Penning, Louis C, Ito, Keita, Meij, Björn P & Tryfonidou, Marianna A (2014). Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC Veterinary Research, 10.
Lavrijsen, Ineke, Heuven, Henri, Meij, Bjorn, Theyse, Lars, Nap, R.C., Leegwater, Peter & Hazewinkel, Herman (2014). Prevalence and co-occurrence of hip dysplasia and elbow dysplasia in Dutch pure-bred dogs. Preventive Veterinary Medicine, 114 (2), (pp. 114-122) (9 p.).
Wangdee, C, Leegwater, P A J, Heuven, H C M, van Steenbeek, F G, Meutstege, F J, Meij, B P & Hazewinkel, H A W (2014). Prevalence and genetics of patellar luxation in Kooiker dogs. Veterinary Journal, 201 (3), (pp. 333-337) (5 p.). Copyright © 2014 Elsevier Ltd. All rights reserved..
  Articles - 2013
Sharifi, S., van Kooten, T.G., Kranenburg, H.C., Meij, B.P., Behl, M., Lendlein, A. & Grijpma, D (2013). An annulus fibrosus closure device based on a biodegradable. Biomaterials, 34 (2013), (pp. 8105-8113) (8 p.).
Smolders, L.A., Meij, B.P., Onis, D., Riemers, F.M., Bergknut, N., Wubbolts, R.W., Grinwis, G.C.M., Houweling, M., Groot Koerkamp, M.J.A., van Leenen, D., Holstege, F.C.P., Hazewinkel, H.A.W., Creemers, L.B., Penning, L.C. & Tryfonidou, M.A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research and Therapy, 15 (1), (pp. R23) (1 p.).
Spillekom, S., Smolders, L.A., Grinwis, G.C.M., Arkesteijn, I., Ito, K., Meij, B.P. & Tryfonidou, M.A. (2013). INCREASED OSMOLARITY AND CELL CLUSTERING PRESERVES CANINE NOTOCHORDAL CELL PHENOTYPE IN CULTURE. Tissue Engineering - Part C: Methods, (pp. 10.1089/ten.TEC.2013.0479.).
Bergknut, N., Meij, B.P., Hagman, R., Nies, K.S., Rutges, J.P.H.J., Smolders, L.A., Creemers, L.B., Lagerstedt, A.S., Hazewinkel, H.A.W. & Grinwis, G.C.M. (2013). Intervertebral disc degeneration in the dog. Part 1: a new histological grading scheme for classification of intervertebral disc degeneration in dogs. Veterinary Journal, 195 (2), (pp. 156-163) (8 p.).
Bergknut, N., Smolders, L.A., Grinwis, G.C.M., Hagman, R., Lagerstedt, A.S., Hazewinkel, H.A.W., Tryfonidou, M.A. & Meij, B.P. (2013). Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration. Veterinary Journal, 195 (3), (pp. 282-291) (10 p.).
Smolders, L.A., Bergknut, N., Grinwis, G.C.M., Hagman, R., Lagerstedt, A.S., Hazewinkel, H.A.W., Tryfonidou, M.A. & Meij, B.P. (2013). Intervertebral disc degeneration in the dog. Part 2: Chondrodystrophic and non-chondrodystrophic breeds. Veterinary Journal, 195, (pp. 292-299) (8 p.).
Kranenburg, H.C., Grinwis, G.C.M., Bergknut, N., Gahrmann, N., Voorhout, G., Hazewinkel, H.A.W. & Meij, B.P. (2013). Intervertebral disc disease in dogs – Part 2: Comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. Veterinary Journal, 195, (pp. 164-171) (8 p.).
Kranenburg, H.C., Meij, B.P. & Hazewinkel, H.A.W. (2013). Spinal hyperostosis in. Veterinary Sciences Tomorrow (15 p.).
Kranenburg, H.C., Hazewinkel, H.A.W. & Meij, B.P. (2013). Spinal hyperostosis in humans and companion animals. Veterinary Quarterly, 33 (1), (pp. 30-42) (12 p.).
van Rijn, Sarah J, Tryfonidou, Marianna A, Hanson, Jeanette M, Penning, Louis C & Meij, Björn P (2013). Stem cells in the canine pituitary gland and in pituitary adenomas. Veterinary Quarterly, 33 (4), (pp. 217-224) (8 p.).
  Articles - 2012
Smolders, L.A., Kingma, I., Bergknut, N., van der Veen, A.J., Dhert, W.J.A., Hazewinkel, H.A.W., van Dieen, J.H. & Meij, B.P. (2012). Biomechanical assessment of the effects of decompressive surgery in non-chondrodystrophic and chondrodystrophic canine multisegmented lumbar spines. European Spine Journal, 21 (9), (pp. 1692-1699) (8 p.).
Smolders, L.A., Bergknut, N., Kingma, I., van der Veen, A.J., Smit, Th.H., Koole, L.H., Hazewinkel, H.A.W. & Meij, B.P. (2012). Biomechanical evaluation of a novel nucleus pulposus prosthesis in canine. Veterinary Journal, 192 (2012), (pp. 199-205) (6 p.).
Smolders, L.A., Meij, B.P., Riemers, F.M., Licht, R., Wubbolts, R.W., van den Heuvel, D.J., Grinwis, G.C.M., Vernooij, Hans, Hazewinkel, H.A.W., Penning, L.C. & Tryfonidou, M.A. (2012). Canonical Wnt Signaling in the Notochordal Cell is Upregulated in Early Intervertebral Disk Degeneration. Journal of Orthopaedic Research, 30 (6), (pp. 950-957) (8 p.).
Bergknut, N. & Meij, B.P. (2012). Degenerative lumbosacral stenosis part 1 Pathogenesis, clinical signs and diagnostics. European Journal of Companion Animal Practice, 22 (1), (pp. 23-33) (10 p.).
Bergknut, N. & Meij, B.P. (2012). Degenerative lumbosacral stenosis part 2: Treatment. European Journal of Companion Animal Practice, 22 (2), (pp. 23-23) (1 p.).
Kranenburg, H.C., Meij, B.P., Onis, D., van der Veen, A.J., Saralidze, K., Smolders, L.A., Huizinga, J., Knetsch, M.L.W., Luijten, P.R., Visser, F., Voorhout, G., Dhert, W.J.A., Hazewinkel, H.A.W. & Koole, L.H. (2012). Design, synthesis, imaging, and biomechanics of a softness-gradient hydrogel nucleus pulposus prosthesis in a canine lumbar spine model. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 100 (8), (pp. 2148-2155) (8 p.).
van Rijn, Sarah J, Gremeaux, Lies, Riemers, Frank M, Brinkhof, Bas, Vankelecom, Hugo, Penning, Louis C & Meij, Björn P (2012). Identification and characterisation of side population cells in the canine pituitary gland. Veterinary Journal, 192 (3), (pp. 476-482) (7 p.). Copyright © 2011 Elsevier Ltd. All rights reserved..
Bergknut, N., Egenvall, A., Hagman, R., Gustas, P., Hazewinkel, H.A.W., Meij, B.P. & Lagerstedt, A.S. (2012). Incidence of intervertebral disk degeneration-related diseases and associated mortality rates in dogs. Journal of the American Veterinary Medical Association, 240 (11), (pp. 1300-1309) (10 p.).
Smets, P., Lefebvre, H.P., Meij, B.P., Croubels, S., Meyer, E., Maele, I. van de & Daminet, S. (2012). Long-Term Follow-Up of Renal Function in Dogs after Treatment for ACTH-Dependent Hyperadrenocorticism. Journal of Veterinary Internal Medicine, 26 (3), (pp. 565-574) (10 p.).
Meij, B.P., Voorhout, G., Gerritsen, R.J., Grinwis, G.C.M. & IJzer, J. (2012). Lymphocytic hypophysitis in a German Longhaired Pointer with diabetes insipidus. Journal of Comparative Pathology, 147, (pp. 503-507) (5 p.).
Lavrijsen, I.C.M., Heuven, H.C.M., Voorhout, G., Meij, B.P., Theyse, L.F.H., Leegwater, P.A.J. & Hazewinkel, H.A.W. (2012). Phenotypic and genetic evaluation of elbow dysplasia in Dutch Labrador Retrievers, Golden Retrievers, and Bernese Mountain dogs. Veterinary Journal, 193 (2012), (pp. 486-492) (7 p.).
Kranenburg, H.C., Meij, B.P., van Hofwegen, E.M., Voorhout, G., Slingerland, L.I., Picavet, P. & Hazewinkel, H.A.W. (2012). Prevalence of spondylosis deformans in the feline spine and correlation with owner-perceived behavioural changes. Veterinary and Comparative Orthopaedics and Traumatology, 25 (3), (pp. 217-223) (7 p.).
Schwencke, M., Smolders, L.A., Bergknut, N., Gustas, P., Meij, B.P. & Hazewinkel, H.A.W. (2012). Soft tissue artifact in canine kinematic gait analysis. Veterinary Surgery, 41 (7), (pp. 829-837) (9 p.).
Bergknut, Niklas, Rutges, Joost P H J, Kranenburg, Hendrik-Jan C, Smolders, Lucas A, Hagman, Ragnvi, Smidt, Hendrik-Jan, Lagerstedt, Anne-Sofie, Penning, Louis C, Voorhout, George, Hazewinkel, Herman A W, Grinwis, Guy C M, Creemers, Laura B, Meij, Björn P & Dhert, Wouter J A (2012). The dog as an animal model for intervertebral disc degeneration?. Spine, 37 (5), (pp. 351-358) (8 p.).
Budry, L., Balsalobre, A., Gauthier, Y., Khetchoumian, K., L'Honore, A., Vallette-Kasic, S., Brue, T, Figarella-Branger, D., Meij, B.P. & Drouin, J. (2012). The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes and Development, 26 (20), (pp. 2299-2310) (12 p.).
Kraus, M.W., Theyse, L.F.H., Tryfonidou, M.A., Hazewinkel, H.A.W. & Meij, B.P. (2012). Treatment of spinal fractures using Lubra plates. A retrospective clinical and radiological evaluation of 15 cases. Veterinary and Comparative Orthopaedics and Traumatology, 25 (4), (pp. 326-331) (6 p.).
Corbee, R.J., Tryfonidou, M.A., Meij, B.P., Kooistra, H.S. & Hazewinkel, H.A.W. (2012). Vitamin D status before and after hypophysectomy in dogs with pituitary-dependent hypercortisolism. Domestic Animal Endocrinology, 42, (pp. 43-49) (7 p.).
  Articles - 2011
Slingerland, L.I., Hazewinkel, H.A.W., Meij, B.P., Picavet, P. & Voorhout, G. (2011). Cross-sectional study of the prevalence and clinical features of osteoarthritis in 100 cats. Veterinary Journal, 187 (2011), (pp. 304-309) (6 p.).
Bergknut, N., Auriemma, E., Wijsman, S.J.C.M., Voorhout, G., Hagman, R., Lagerstedt, A.S., Hazewinkel, H.A.W. & Meij, B.P. (2011). Evaluation of intervertebral disk degeneration in chondrodystrophic and nonchondrodystrophic dogs by use of Pfirrmann grading of images obtained with low-field magnetic resonance imaging. American Journal of Veterinary Research, 72 (7), (pp. 893-898) (6 p.).
Sharifi, K., Kranenburg, H.C., Meij, B.P. & Grijpma, D. (2011). Photo-Crosslinkable Poly(trimethylene carbonate)-Based Macromers for Closure of Ruptured Intervertebral Discs. Macromolecular Symposia, 309-310 (1), (pp. 100-110) (11 p.).
Bergknut, N., Grinwis, G.C.M., Pickee, E., Auriemma, E., Lagerstedt, A.S., Hagman, R., Hazewinkel, H.A.W. & Meij, B.P. (2011). Reliability of macroscopic grading of intervertebral disk degeneration in dogs by use of the Thompson system and comparison with low-field magnetic resonance imaging findings. American Journal of Veterinary Research, 72 (7), (pp. 899-904) (6 p.).
  Articles - 2010
Veraa, S., Dijkman, R., Meij, B.P. & Voorhout, G. (2010). Comparative imaging of spinal extradural lymphoma in a Bordeaux dog. Canadian Veterinary Journal, 51 (5), (pp. 519-521) (3 p.).
Meij, B.P. & Bergknut, N. (2010). Degenerative lumbosacral stenosis in dogs. Veterinary Clinics of North America - Small Animal Practice, 40 (5), (pp. 983-1009) (27 p.).
van Rijn, S J, Grinwis, G C M, Penning, L C & Meij, B P (2010). Expression of Ki-67, PCNA, and p27kip1 in canine pituitary corticotroph adenomas. Domestic Animal Endocrinology, 38 (4), (pp. 244-252) (9 p.). Copyright (c) 2009 Elsevier Inc. All rights reserved..
Hanson, J.M., Mol, J.A. & Meij, B.P. (2010). Expression of leukemia inhibitory factor and leukemia inhibitory factor receptor in the canine pituitary gland and corticotrope adenomas. Domestic Animal Endocrinology, 38 (4), (pp. 260-271) (12 p.).
Meij, B.P., Auriemma, E., Grinwis, G.C.M., Buijtels, J.J.C.W.M. & Kooistra, H.S. (2010). Successful treatment of acromegaly in a diabetic cat with transsphenoidal hypophysectomy. Journal of Feline Medicine and Surgery, 12 (5), (pp. 406-410) (5 p.).
Kranenburg, H.C., Westerveld, L.A., Verlaan, J.J., Oner, F.C., Dhert, W.J.A., Voorhout, G., Hazewinkel, H.A.W. & Meij, B.P. (2010). The dog as an animal model for DISH?. European Spine Journal, 19 (8), (pp. 1325-1329) (5 p.).
  Articles - 2009
Bovenkamp, C.G., Meij, B.P., Stassen, Q.E.M., Nijsen, J.F.W & Kirpensteijn, J. (2009). [Administration of radioactive holmium-166 microsphere in domestic animals with inoperable tumors]. Tijdschrift voor Diergeneeskunde, 134, (pp. 532-533) (2 p.).
Auriemma, E., Barthez, P.Y.G., van der Vlugt-Meijer, R.H., Voorhout, G. & Meij, B.P. (2009). Computed tomography and low-field magnetic resonance imaging of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism: 11 cases (2001-2003). Journal of the American Veterinary Medical Association, 235, (pp. 409-414) (6 p.).
de Bruin, C., Meij, B.P., Kooistra, H.S., Hanson, J.M., Lamberts, S.W.J. & Hofland, L.J. (2009). Cushing's disease in dogs and humans. Hormone Research, 71 (1), (pp. 140-143) (4 p.).
Kooistra, H.S., Galac, S., Buijtels, J.J.C.W.M. & Meij, B.P. (2009). Endocrine diseases in animals. Hormone Research, 71 (1), (pp. 144-147) (4 p.).
  Articles - 2008
de Bruin, C., Hanson, J.M., Meij, B.P., Kooistra, H.S., Waaijers, A.M., Uitterlinden, P., Lamberts, S.W.J. & Hofland, L.J. (2008). Expression and functional analysis of dopamine D2 and somatostatin receptor subtypes in canine Cushing's disease. Endocrinology, 149, (pp. 4357-4366) (10 p.).
Hanson, J.M., Mol, J.A., Leegwater, P.A.J., Bilodeau, S., Drouin, J. & Meij, B.P. (2008). Expression and mutation analysis of Tpit in the canine pituitary gland and corticotroph adenomas. Domestic Animal Endocrinology, 34, (pp. 454-460) (7 p.).
Suwankong, N., Meij, B.P., Voorhout, G., de Boer, A.H. & Hazewinkel, H.A.W. (2008). Review and retrospective analysis of degenerative lumbosacral stenosis in 156 dogs treated by dorsal laminectomy. Veterinary and Comparative Orthopaedics and Traumatology, 21 (3), (pp. 285-293) (9 p.).
  Articles - 2007
Suwankong, N., Meij, B.P., van Klaveren, N.J., Wees, A.M., Meijer, E., van den Brom, W.E. & Hazewinkel, H.A.W. (2007). Assessment of decompressive surgery in dogs with degenerative lumbosacral stenosis using force plate analysis and questionnaires. Veterinary Surgery, 36, (pp. 423-431) (8 p.).
Meij, B.P., Suwankong, N., van der Veen, A.J. & Hazewinkel, H.A.W. (2007). Biomechanical flexion-extension forces in normal canine lumbosacral cadaver specimens before and after dorsal laminectomy-discectomy and pedicle screw-rod fixation. Veterinary Surgery, 36, (pp. 742-751) (10 p.).
van der Vlugt-Meijer, R.H., Meij, B.P. & Voorhout, G. (2007). Dynamic helicat computed tomography of the pituitary gland in healthy dogs. Veterinary Radiology and Ultrasound, 48 (48), (pp. 118-124) (6 p.).
Amann, O., Meij, B.P., Westerhof, I., Kik, M.J.L., Lumeij, J.T. & Schoemaker, N.J. (2007). Giant Cell Tumor of the Bone in a Scarlet Macaw (Ara macao). Avian Diseases, 51, (pp. 146-149) (4 p.).
Hanson-Nilsson, J.M., Teske, E., Voorhout, G., Galac, S., Kooistra, H.S. & Meij, B.P. (2007). Prognostic factors for outcome after transsphenoidal hypophysectomy in dogs with pituitary-depent hyperadrenocorticism. Journal of Neurosurgery, 107, (pp. 830-840) (11 p.).
  Articles - 2006
Kouwenhoven, J.W.M., Vincken, K.L., Bartels, L.W., Meij, B.P., Oner, F.C. & Castelein, R.M. (2006). Analysis of pre-existent vertebral rotation in the normal quadruped spine. Spine, 31 (20), (pp. 754-758) (5 p.).
van der Vlugt-Meijer, R.H., Meij, B.P. & Voorhout, G. (2006). Intraobserver and interobserver agreement, reproducducibility, and accurancy of computed tomographic measurements of pituitary gland dimensions in healthy dogs. American Journal of Veterinary Research, 67 (10), (pp. 1750-1755) (5 p.).
Schotanus, B.A., Meij, B.P., Vos, I.H.C., Kooistra, H.S. & Everts, M.E. (2006). Na(+), K(+)-ATPase content in skeletal muscle of dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology, 30, (pp. 320-332) (13 p.).
Hanson-Nilsson, J.M., Kooistra, H.S., Mol, J.A., Teske, E. & Meij, B.P. (2006). Plasma profiles of adrenocorticotropic hormone, cortisol, alpha-melanocyte-stimulating hormone, and growth hormone in dogs with pituitary-dependent hyperadrenocorticism before and after hypophysectomy. Journal of Endocrinology, 190 (3), (pp. 601-609) (9 p.).
Meij, B.P. & Hanson-Nilsson, J.M. (2006). Prognostic factors for pituitary surgery in dogs with Cushing's disease. Hormones. Journal of Clinical Endocrinology and Metabolism, 5 (1), (pp. 56) (1 p.).
Bilodeau, S., Vallette-Kasic, S., Gauthier, Y., Figarella-Branger, D., Brue, T, Berthelet, F., Lacroix, A., Batista, J.E., Stratakis, C., Hanson-Nilsson, J.M., Meij, B.P. & Drouin, J. (2006). Role of Brg1 and HDAC2 in GR trans-repression of the pituitary POMC gene and misexpression in Cushing disease. Genes and Development, 15 (20), (pp. 2871-2886) (16 p.).
Hanson-Nilsson, J.M., Mol, J.A., Leegwater, P.A.J., Kooistra, H.S. & Meij, B.P. (2006). The leukemia inhibitory factor receptor gene is not involved in the etiology of pituitary dwarfism in German shepherd dogs. Research in Veterinary Science, 81 (3), (pp. 316-320) (5 p.).
van der Vlugt-Meijer, R.H., Meij, B.P. & Voorhout, G. (2006). Thin-slice three-dimensional grdient-echo magnetic resonance of the pituitary gland in healthy dogs. American Journal of Veterinary Research, 67 (11), (pp. 1865-1872) (8 p.).
Meij, B.P., Suwangkong, N., van den Brom, W.E., Venker-van Haagen, A.J. & Hazewinkel, H.A.W. (2006). Tibial nerve somatosensory evoked potentials in dogs with degenerative lumbosacral stenosis. Veterinary Surgery, 35, (pp. 168-175) (9 p.).
  Articles - 2005
Hanson-Nilsson, J.M., van 't Hoofd, M.M., Voorhout, G., Teske, E., Kooistra, H.S. & Meij, B.P. (2005). Efficacy of transsphenoidal hypophysectomy in treatment of dogs with pituitary-dependent hyperadrenocorticism. Journal of Veterinary Internal Medicine, 19, (pp. 687-694) (8 p.).
van Klaveren, N.J., Suwankong, N., de Boer, S., van den Brom, W.E., Voorhout, G., Hazewinkel, H.A.W. & Meij, B.P. (2005). Force plate analysis before and after dorsal decompression for treatment of degenerative lumbosacral stenosis in dogs. Veterinary Surgery, 34, (pp. 450-456) (7 p.).
Galac, S., Kooistra, H.S., Voorhout, G., van den Ingh, T.S.G.A.M., Mol, J.A., van den Berg, L. & Meij, B.P. (2005). Hyperadrenocorticism in a dog due to ectopic secretion of adrenocorticotropic hormone. Domestic Animal Endocrinology, 28, (pp. 338-348) (11 p.).
Meij, B.P., van der Vlugt-Meijer, R.H., van den Ingh, T.S.G.A.M., Flik, G. & Rijnberk, A. (2005). Melanotroph Pituitary Adenoma in a Cat with Diabetes Mellitus. Veterinary Pathology, 42, (pp. 92-97) (6 p.).
  Articles - 2004
van der Vlugt-Meijer, R.H., Meij, B.P. & Voorhout, G. (2004). Dynamic computed tomographic evaluation of the pituitary gland in healthy dogs. American Journal of Veterinary Research, 65, (pp. 1518-1524) (7 p.).
Meij, B.P., van der Vlugt-Meijer, R.H., van den Ingh, T.S.G.A.M. & Rijnberk, A. (2004). Somatotroph and Corticotroph Pituitary Adenoma (Double Adenoma) in a Cat with Diabetes Mellitus and Hyperadrenocorticism. Journal of Comparative Pathology, 130, (pp. 209-215) (7 p.).
Geerars-van Vonderen, I.K., Kooistra, H.S., Timmermans-Sprang, E.P.M., Meij, B.P. & Rijnberk, A. (2004). Vasopressin response to osmotic stimulation in 18 young dogs with polyuria and polydipsia. Journal of Veterinary Internal Medicine, 18, (pp. 800-806) (6 p.).
Geerars-van Vonderen, Ilse, Kooistra, Hans, Sprang, E.P.M., Meij, Björn & Rijnberk, Ad (2004). Vasopressin response to osmotic stimulation in 18 young dogs with polyuria and polydipsia. Journal of Veterinary Internal Medicine, 18 (6), (pp. 800-6).
  Articles - 2003
van der Vlugt-Meijer, R.H., Meij, B.P., van den Ingh, T.S.G.A.M., Rijnberk, A. & Voorhout, G. (2003). Dynamic computed tomography of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism. Journal of Veterinary Internal Medicine, 17, (pp. 773-780) (8 p.).
van den Boom, R., Rijkenhuizen, A.B.M. & Meij, B.P. (2003). Femoral head ostectomy following osteotomy of the greater trochanter in a pony with chronic coxofemoral luxation. Pferdeheilkunde, 19, (pp. 246-252) (7 p.).
Rijnberk, A., Kooistra, H.S., Bhatti, S.F., Lee, W.M., Mol, J.A. & Meij, B.P. (2003). Pulsatile secretion pattern of growth hormone in dogs with pituitary-dependent hyperadrenocorticism. Domestic Animal Endocrinology, 44, (pp. 59-68) (10 p.).
  Articles - 2002
van der Vlugt-Meijer, R.H., Voorhout, G. & Meij, B.P. (2002). Imaging of the pituitary gland in dogs with pituitary-dependent hyperadrenocorticism. Molecular and Cellular Endocrinology, 197, (pp. 81-87) (7 p.).
Meij, B.P. & Frost-Christensen, L.N. (2002). Nerve sheath tumors. Veterinary and Comparative Orthopaedics and Traumatology, 15, (pp. A25-A25) (1 p.).
Meij, B.P., Voorhout, G. & Rijnberk, A. (2002). Progress in transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocorticism in dogs and cats . Molecular and Cellular Endocrinology, 197, (pp. 89-96) (8 p.).
Meij, B.P., Lopes, M.B.S.., Ellegala, D.B., Alden, T.D. & Jr. Laws, E.R. (2002). The long-term significance of microscopic dural invasion in 354 patients with pituitary adenomas treated with transsphenoidal hypophysectomy. Journal of Neurosurgery, 96, (pp. 195-208) (14 p.).
  Articles - 2001
Meij, B.P., Lopes, M.B.S.., Vance, M.L., Thorner, M.O. & Jr. Laws, E.R. (2001). Double pituitary lesions in three patients with Cushing's disease. Pituitary, 3, (pp. 159-168) (10 p.).
Meij, B.P. (2001). Geschiedenis van de hypofysechirurgie bij mens en dier: van experimenten bij honden naar behandeling van patiënten. Tijdschrift voor Diergeneeskunde, 154, (pp. 2478-2482) (5 p.).
Meij, B.P. (2001). Hypophysectomy as a treatment for canine and feline Cushing's disease. Veterinary Clinics of North America - Small Animal Practice, 31, (pp. 1015-1041) (27 p.). Endocrinology.
Meij, B.P. (2001). Shar-Pei met recidiverende kreupelheid. Vraag en Antwoord. Tijdschrift voor Diergeneeskunde, 126, (pp. 133-134) (2 p.).
Meij, B.P., Lopes, M.B.S.. & Jr. Laws, E.R. (2001). The significance of microscopic dural invasion in patients with pituitary adenomas treated by transsphenoidal surgery. Pituitary, 3, (pp. 17-17) (1 p.).
Meij, B.P., Voorhout, G., van den Ingh, T.S.G.A.M. & Rijnberk, A. (2001). Transsphenoidal hypophysectomy for treatment of pituitary-dependent hyperadrenocortism in 7 cats. Veterinary Surgery, 30, (pp. 72-86) (15 p.).
  Articles - 1998
Quist, J.J., Dhert, W.J.A., Meij, B.P., Visser, W., Öner, F.C., Hazewinkel, H.A.W. & Verbout, A.J. (1998). The prevention of peridural adhesions. A comparative long-term histomorphometric study using a biodegradable barrier and a fat graft. Journal of Bone and Joint Surgery - Series B, 80-B, (pp. 520-526) (7 p.).
  Articles - 1997
van Wijk, P.A., Rijnberk, A., Croughs, R.J.M., Meij, B.P., van Leeuwen, I.S., Sprang, E.P.M. & Mol, J.A. (1997). Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-depen dent hyperadrenocorticism. Journal of Endocrinological Investigation, 20, (pp. 1-7) (7 p.).
  Book parts / chapters - 2014
de Vries, S., Potier, E., Doeselaar, M., Meij, B., Tryfonidou, M. & Ito, K. (14.05.2014). Stimulation of Canine Nucleus Pulposus Cells and Bone Marrow-Derived Stromal Cells with Notochordal Cell-Secreted Factors. Global Spine Journal (pp. po.089).
  Book parts / chapters - 2013
Kranenburg, H.C., Ito, K., Tryfonidou, M.A., Smolders, L.A., Bergknut, N., Oner, F.C., Hazewinkel, H.A.W., Dhert, W.J.A. & Meij, B.P. (2013). Animal Models for Disc Degeneration. In A.D. Sharan, S.Y. Tang & A.R. Vaccaro (Eds.), Basis Science of Spinal Diseases (pp. 44-51) (7 p.). New Delhi India: Jaypee Brothers Medical Publishers.
  Book parts / chapters - 2010
Meij, B.P. & Bergknut, N. (2010). Degenerative lumbosacral stenosis in dogs. Veterinary Clinics of North America: Small Animal Practice (pp. 983-1009) (27 p.). Elsevier, Spinal Diseases.
Meij, B.P., Kooistra, H.S. & Rijnberk, A. (2010). Hypothalamus-Pituitary system. In A. Rijnberk & H.S. Kooistra (Eds.), Clinical Endocrinology of Dogs and Cats, 2nd ed. (pp. 13-54) (338 p.). Hannover, Germany: Schlütersche.
Meij, B.P., Robben, J.H., Kooistra, H.S. & Reusch, C.E. (2010). Treatment protocols. In H.S. Kooistra & A. Rijnberk (Eds.), Clinical Endocrinology of Dogs and Cats, 2nd ed. (pp. 291-295) (5 p.). Hannover, Germany: Schlütersche.
  Book parts / chapters - 2008
Meij, B.P. & Mol, J.A. (2008). Adrenocortical Function. In JJ Kaneko, JW Harvey & ML Bruss (Eds.), Clinical Biochemistry of Domestic Animals (16 p.). USA: Academic Press.
Mol, J.A. & Meij, B.P. (2008). Pituitary function. In JJ Kaneko, JW Harvey & ML Bruss (Eds.), Clinical Biochemistry of Domestic Animals (pp. 561-604) (44 p.). USA: Academic Press.
  Book parts / chapters - 2005
Hazewinkel, H.A.W., Meij, B.P., Theyse, L.F.H. & van Rijssen, B. (2005). Hoofdstuk 17 : Locomotieapparaat. In A. Rijnberk & F.J. van Sluijs (Eds.), Anamnese en lichamelijk onderzoek bij gezelschapsdieren (pp. 167-194) (28 p.). Houten: Bohn Stafleu van Loghum.
van Nes, J.J., Meij, B.P. & van Ham, L. (2005). Hoofdstuk 18 : Zenuwstelsel. In A. Rijnberk & F.J. van Sluijs (Eds.), Anamnese en lichamelijk onderzoek bij gezelschapsdieren (pp. 195-210) (16 p.). Houten: Bohn Stafleu van Loghum.
  Articles in volumes / proceedings - 2012
Bergknut, N., Meij, B.P., Hagman, R., Nies, K.D., Rutges, J.P.H.J., Smolders, L.A., Creemers, L.B., Lagerstedt, A.S., Hazewinkel, H.A.W. & Grinwis, G.C.M. (2012). A new histological grading scheme for classification of intervertebral disc degeneration in dogs. Proceedings Annual Congress European Society and College of Veterinary Neurology (ECVS & ECVN) Annual Congress European Society and College of Veterinary Neurology (ECVS & ECVN), 13-15 September 2012, Ghent, Belgium..
Smolders, L.A., Meij, B.P., Onis, D., Riemers, F.M., Bergknut, N., Wubbolts, R.W., Grinwis, G.C.M., Groot Koerkamp, M., Holstege, F.C., Hazewinkel, H.A.W., Creemers, L.B., Penning, L.C. & Tryfonidou, M.A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration suggests a crucial role of caveolin-1 in notochordal cell preservation. Proceedings European Veterinary Conference Voorjaarsdagen 2012 (pp. 236-237) (2 p.). European Veterinary Conference Voorjaarsdagen 2012, April 5-7, Amsterdam RAI, the Netherlands.
Smolders, L.A., Onis, D., Riemers, F.M., Penning, L.C., Bergknut, N., Kranenburg, H.C., Hazewinkel, H.A.W., Grinwis, G.C.M., Groot Koerkamp, M., Meij, B.P. & Tryfonidou, M.A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration. Abstract Book Spineweek 2012 (pp. 256) (1 p.). Spineweek 2012, 28 May-1 June, Amsterdam, Netherlands.
Smolders, L.A., Meij, B.P., Onis, D., Riemers, F.M., Bergknut, N., Wubbolts, R.W., Grinwis, G.C.M., Groot Koerkamp, M., Holstege, F.C., Hazewinkel, H.A.W., Creemers, L.B., Penning, L.C. & Tryfonidou, M.A. (2012). Identification of a novel biomolecular target for regeneration of the degenerated canine intervertebral disc. Proceedings 25th annual symposium of the European Society of Veterinary Neurology (ECVN) and European College of Veterinary Neurology (ESVN) (pp. 14-14) (1 p.). Annual symposium of the European Society of Veterinary Neurology (ECVN), September 13-15,Ghent, Belgium..
Willems, N., Tryfonidou, M.A., Meij, B.P., Hazewinkel, H.A.W., Creemers, L.B., Licht, R., Dhert, W.J.A., Schuman, D., van Dijk, M., de Leeuw, M., Piest, M., Papen-Boterhuis, N.E. & Langelaan, M. (2012). Injection of (un)loaded hydrogels and microspheres in intervertebral discs of laboratory beagle dogs. Proceedings BMM / TERM Annual Meeting (pp. 17-17) (1 p.). BMM / TERM Annual Meeting 2012, Ermelo, 17-18 september 2012.
Bergknut, N., Rutges, J.P.H.J., van Tiel, J., Waarsing, H.J., Meij, B.P., Hazewinkel, H.A.W., Penning, L.C., Lagerstedt, A.S., Hagman, R., Creemers, L.B. & Dhert, W.J.A. (2012). Intervertebral disc regeneration in a rabbit annular puncture model using BMP-7 and Marimastat. Proceedings Annual Congress European Society and College of Veterinary Neurology (ECVS & ECVN) Annual Congress European Society and College of Veterinary Neurology (ECVS & ECVN), 13-15 September 2012, Ghent, Belgium..
  Articles in volumes / proceedings - 2010
Bergknut, N., Smolders, L.A., Koole, L.H., Saralidze, K., Voorhout, G., Hagman, R.E., Lagerstedt, A.S., van der Veen, A.J., Hazewinkel, H.A.W. & Meij, B.P. (22.04.2010). An imaging study of a nucleus pulposus hydrogel in canine cadaveric spines. Proceedings European Veterinary Conference Voorjaarsdagen (pp. 250-251) (2 p.). Amsterdam, European Veterinary Conference Voorjaarsdagen.
Smolders, L.A., Voorhout, G., van de Ven, R., Bergknut, N., Grinwis, G.C.M., Hazewinkel, H.A.W. & Meij, B.P. (16.09.2010). Assessment of safe corridors for pedicle screw insertion in canine lumbosacral vertebrae. Proceeding 23d Annual Symposium of the ECVN & ESVN (pp. 108-108) (1 p.). Cambridge, 23d Annual Symposium of the ECVN & ESVN.
Smolders, L.A., Voorhout, G., van de Ven, R., Bergknut, N., Grinwis, G.C.M., Hazewinkel, H.A.W. & Meij, B.P. (08.04.2010). Assessment of safe corridors for pedicle screw insertion in canine lumbosacral vertebras. Proceedings of British Small Animal Veterinary Association (pp. 403-403) (1 p.). Birmingham, UK: BSAVA, BSAVA 2010.
Meij, B.P., Smolders, L.A. & Bergknut, N. (01.09.2010). Canine intervertebral disc degeneration. Proceeding 3rd International Congress Biotechnologies for Spinal Surgery (pp. 1395-1412) (18 p.). International Congress Biotechnologies for Spinal Surgery.
Bergknut, N., Egenvall, A., Hagman, R.E., Gustas, P., Meij, B.P., Hazewinkel, H.A.W. & Lagerstedt, A.S. (22.04.2010). Incidence of lumbosacral disease in a population of 800 000 Swedish dogs. Proceedings Voorjaarsdagen European Veterinary Conference (pp. 250-250) (1 p.). Amsterdam.
Meij, B.P., Hanson-Nilsson, J.M. & Mol, J.A. (22.09.2010). Predictive value of postoperative plasma ACTH, α-MSH, and cortisol concentrations for recurrence after hypophysectomy in dogs with Cushing's disease. Proceedings European Neuroendocrine Association (ENEA) (pp. 76-76) (1 p.). Liège, Belgium, European Neuroendocrine Association (ENEA).
Bergknut, N., Rutges, J.P.H.J., Smolders, L.A., Kranenburg, H.C., Hagman, R.E., Lagerstedt, A.S., Grinwis, G.C.M., Voorhout, G., Creemers, L.B., Dhert, W.J.A., Hazewinkel, H.A.W. & Meij, B.P. (01.09.2010). The dog as a spontaneous animal model for human intervertebral disc degeneration. Proceedings 3rd International Congress Biotechnologies for Spinal Surgery, BIOSPINE 3 (pp. 1399-1400) (2 p.). Amsterdam, 3rd International Congress Biotechnologies for Spinal Surgery, BIOSPINE 3.
Kranenburg, H.C., Westerveld, A., Verlaan, J.J., Oner, F.C., Dhert, W.J.A., Voorhout, G., Hazewinkel, H.A.W. & Meij, B.P. (22.04.2010). The prevalence of diffuse idiopathic skeletal hyperostosis in dogs. Proceedings European Veterinary Conference Voorjaarsdagen (pp. 247-247) (1 p.). Amsterdam, European Veterinary Conference Voorjaarsdagen.
  Articles in volumes / proceedings - 2009
van de Ven, R., Bergknut, N., Voorhout, G. & Meij, B.P. (23.04.2009). Assessment of safe corridors for pedicle screw insertion in canine lumbosacral vertebras. Proceedings Voorjaarsdagen European Veterinary Conference (pp. 314-314) (1 p.). Amsterdam, Voorjaarsdagen European Veterinary Conference.
Smolders, L.A., Bergknut, N., van der Veen, A., Kingma, I., Koole, L.H., Gustas, P., Hazewinkel, H.A.W. & Meij, B.P. (23.04.2009). Biomechanical testing of a lumbosacral nucleus pulposus prosthesis: a canine cadaver study. Proceedings European Veterinary Conference Voorjaarsdagen (pp. 311-311) (1 p.). Amsterdam, European Veterinary Conference Voorjaarsdagen.
van Gerwen, L.W.M., Bergknut, N., Hazewinkel, H.A.W., Voorhout, G., Auriemma, E., Grinwis, G.C.M. & Meij, B.P. (23.04.2009). Canine intervertebral disc degeneration: a comparative study on clinical signs, radiography, MRI and histology. Proceedings Voorjaarsdagen European Veterinary Conference (pp. 296-296) (1 p.). Amsterdam, Voorjaarsdagen European Veterinary Conference.
Wijsman, S.J.C.M., Bergknut, N., Hazewinkel, H.A.W., Voorhout, G., Auriemma, E., Meij, B.P. & Hagman, R.E. (23.04.2009). Feasibility of the Pfirrmann grading system for intervertebral disc degeneration in chondrodystrophic and nonchondrodystrophic dogs. Proceedings Voorjaarsdagen European Veterinary Conference (pp. 318-318) (1 p.). Amsterdam, Voorjaarsdagen European Veterinary Conference.
Schwencke, M., Bergknut, N., Meij, B.P., Gustas, P. & Hazewinkel, H.A.W. (23.04.2009). Soft tissue artefact in canine kinematic gait analysis. A pilot study. Proceedings Voorjaarsdagen European Veterinary Conference (pp. 283-283) (1 p.). Amsterdam, Voorjaarsdagen European Veterinary Conference.
Pickée, E.B., Bergknut, N., Meij, B.P., Auriemma, E., Lagerstedt, A.S. & Grinwis, G.C.M. (23.04.2009). Validation of the macroscopic scoring scheme according to Thompson for pathological changes in the intervertebral disc degeneration in canine cadaveric spines and correlation with imaging findings using low field magnetic resonance imaging. Proceedings Voorjaarsdagen European Veterinary Conference (pp. 308-308) (1 p.). Amsterdam, Voorjaarsdagen European Veterinary Conference.
  Articles in volumes / proceedings - 2007
Meij, B.P. (2007). Oral approach to the brain and hypophysectomy. European College of Veterinary Surgeons (ECVS) 2007 (pp. 363-368) (6 p.). European College of Veterinary Surgeons (ECVS) 2007, Dublin, Ireland,.
Meij, B.P. (2007). Postoperative plasma profiles after transsphenoidal hypophysectomy in treatment of dogs with pituitary-dependent hyperadrenocorticism. Proceedings European College of Veterinary Medicine (ECVIM (pp. 199) (1 p.). European Society of Veterinary Endocrinology (ESVE), Budapest Hungary.
Meij, B.P. (30.03.2007). Progress in pituitary surgery for dogs and cats with Cushing’s disease: where do we stand today?. The Federation of European Companion Animal Veterinary Associations (pp. 43-45) (3 p.). (FECAVA 2007), 30 March 2007, Dubrovnik.
de Bruin, C., Hanson-Nilsson, J.M., Meij, B.P., Kooistra, H.S., Waaijers, A.M., Uiterlinden, P., Lamberts, S.W.J. & Hofland, L.J. (02.06.2007). Somatostatin subtype 2 receptor predominance in canine corticotroph adenomas. Somatostatin subtype 2 receptor predominance in canine corticotroph adenomas (pp. 4-45) (42 p.). 89th Annual Meeting, The Endocrine Society, Toronto, Canada.
  Articles in volumes / proceedings - 2006
Meij, B.P. & Westerhof, I. (08.11.2006). Avian fracture repair. Tips & Techniques. European Society of Veterinary Orthopaedics and Traumatology (pp. 107-109) (3 p.). ESVOT Munich Germany.
Meij, B.P. (20.04.2006). Cervical and thoracolumbar disc disease: diagnosis and treatment. European Veterinary Conference (pp. 225-228) (4 p.). Amsterdam, Voorjaarsdagen 2006.
Meij, B.P. (29.10.2006). Cervical spine problems causing forelimb lameness: a diagnostic and therapeutic challenge. 4th International Symposium on Rehabilitation and Physical Therapy in Veterinary Medicine (pp. 1-4) (4 p.). Arnhem, 4th International Symposium on Rehabilitation and Physical Therapy in Veterinary Medicine.
Meij, B.P. (2006). Help! Mijn hond heeft het aan zijn rug. European Veterinary Conference DANS 2006 (pp. 18-19) (2 p.).
Meij, B.P. (2006). Nerve sheat and spinal cord tumors: diagnosis and surgery. European Veterinary Conference (pp. 229-231) (3 p.). European Veterinary Conference.
Meij, B.P., Suwangkong, N., van Klaveren, N.J. & Hazewinkel, H.A.W. (09.09.2006). Surgical decompression for degenerative lumbosacral stenosis-long term result. European Society of Veterinary Orthopaedics and Traumtology (pp. 110-111) (2 p.).
  Articles in volumes / proceedings - 2005
Meij, B.P. (11.05.2005). Cervical and thoracolumbar disc disease:diagnosis and treatment. Proceedings WSAVA World Congress 2005 (pp. 811-818) (8 p.). 30th WSAVA World Congress, Mexico City, Mexico.
Meij, B.P. & Hazewinkel, H.A.W. (11.05.2005). Clinical investigation and radiological findings in dogs with elbow dysplasia ( ED ). Proceedings WSAVA World Congress 2005 (6 p.). 30th WSAVA World Congress, Mexico City, Mexico.
Meij, B.P. & Hazewinkel, H.A.W. (11.05.2005). Nonsurgical and surgical treatment of canine elbow dysplasia. Proceedings WSAVA World Congress 2005 (6 p.). 30th WSAVA World Congress, Mexico City, Mexico.
Meij, B.P. (01.09.2005). Pituitary surgery in dogs and cats - where do we stand today ?. ECVIM-CA Congress Proceedings (pp. 141-143) (3 p.). 15th ECVIM-CA Congress, Glasgow, Scotland.
Meij, B.P. (11.05.2005). Spinal cord and nerve sheath tumors: diagnosis and surgery. Proceedings WSAVA World Congress 2005 (pp. 827-830) (4 p.). 30th WSAVA World Congress, Mexico City, Mexico.
  Articles in volumes / proceedings - 2002
Meij, B.P., Voorhout, G. & Rijnberk, A. (05.07.2002). Long-term results after pituitary surgery for Cushing's disease in dogs and cats. Proceedings European College of Veterinary Surgeons ECVS. (pp. 360-363) (4 p.). Vienna, Austria..
Meij, B.P. (05.09.2002). Surgical arthrodesis of cervical instability. Proceedings 1st World Orthopaedic Veterinary Congress ESVOT-VOS. (pp. 144-145) (2 p.).
  Articles in volumes / proceedings - 2001
Meij, B.P. (01.09.2001). Neurologische beelden. Symposium Kijken, Luisteren en Voelen. De zintuiglijke waarneming in de diagnostiek bij gezelschapsdieren, Utrecht The Netherlands. (pp. 17-19) (3 p.).
Meij, B.P. (29.08.2001). Pituitary function tests. Pre-congress day Symposium Comparative Clinical and Molecular Endocrinology, Utrecht The Netherlands. (pp. 52-56) (5 p.).
Meij, B.P. (29.08.2001). Pituitary surgery. Pre-congress day Symposium Comparative Clinical and Molecular Endocrinology, Utrecht The Netherlands. (pp. 72-75) (4 p.).
  Articles in volumes / proceedings - 2000
Meij, B.P. (25.05.2000). Cushing's disease - medicine or surgery?. Proceedings of the 18th Annual Forum of the American College of Veterinary Internal Medicine (pp. 323-324) (2 p.). Seattle, USA, 18th Annual Forum of the American College of Veterinary Internal Medicine.
Meij, B.P. (25.05.2000). Hypophysectomy for canine Cushing's disease. Proceedings of the 18th Annual Forum of the American College of Veterinary Internal Medicine (pp. 317-319) (3 p.). Seattle, USA, 18th Annual Forum of the American College of Veterinary Internal Medicine.
Hazewinkel, H.A.W., Theyse, L.F.H. & Meij, B.P. (2000). Nutrition and developmental disease of the front leg. 29th WSAVA/FECAVA congres (pp. 385-386) (2 p.).
  Awards - 0
B.P. Meij () An imaging study of a nucleus pulposus hydrogel in canine cadaveric spines
B.P. Meij () Progressive paraparesis and ataxia in a cat
  Lectures - 2010
B.P. Meij (01.09.2010) Canine intervertebral disc degeneration
B.P. Meij (22.09.2010) Identification and characterization of a side population of cells isolated after fluorescence activated cell sorting of the canine pituitary gland
B.P. Meij (27.02.2010) Postgraduate course Articular Surgery of the Forelimb
B.P. Meij (12.06.2010) Postgraduate course Neurosurgery
B.P. Meij (22.09.2010) Predictive value of postoperative plasma ACTH, a-MSH, and cortisol concentrations for recurrence after hypophysectomy in dogs with Cushing's disease
B.P. Meij (10.06.2010) Uitdagende neurologische en neurochirurgische casuistieken
  Lectures - 2009
B.P. Meij (24.10.2009) Transsphenoidal hypophysectomy in dogs and cats: where do we stand today?
B.P. Meij (29.09.2009) Transsphenoidal hypophysectomy in dogs and cats: where do we stand today?
  Lectures - 2007
B.P. Meij (30.03.2007) Degenerative lumbosacral stenosis in dogs: diagnosis and results of treatment
B.P. Meij (30.06.2007) Oral approach to the brain and hypophysectomy
B.P. Meij (28.04.2007) Pedicle screw-rod fixation in canine cadavers.
B.P. Meij (30.03.2007) Peripheral nerve sheath and spinal cord tumors: diagnosis and treatment
B.P. Meij (30.03.2007) Progress in pituitary surgery for dogs and cats with Cushing’s disease: where do we stand today?
B.P. Meij (19.06.2007) Surgical technique of transsphenoidal hypophysectomy for pituitary adenomas in dogs
B.P. Meij (19.04.2007) Surgical techniques
  Lectures - 2006
B.P. Meij (09.11.2006) Avian fracture repair. Tips & techniqeus
B.P. Meij (22.04.2006) Cervical and thoracolumbar disc disease: diagnosis anfd treatment
B.P. Meij (29.10.2006) Cervical spine problems causing forelimb lameness: a diagnostic and therapeutic challenge
B.P. Meij (21.04.2006) Help! Mijn hond heeft het aan zijn rug
B.P. Meij (21.04.2006) Nerve sheat and spinal cord tumoer: diagnosis and surgery
B.P. Meij (24.10.2006) Prognostic factors for pituitary surgery in dogs with Cushing's disease.
B.P. Meij (17.09.2006) Surgical decompression for degenerative lumbosacral stenosis-long term result
B.P. Meij (17.09.2006) The combined anterior function test
  Contribution to the work of national or international committees and working groups - 0
B.P. Meij () WP leader 4
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Gegenereerd op 2017-11-20 07:08:31
Project:
P15-23 William Hunter Revisited: Activating intrinsic cartilage repair to restore joint homeostasis
01.03.2017 to 31.03.2022
General project description 

In his famous textbook “On the diseases of articulating surfaces” published in the year 1743, William Hunter wrote “If we consult the standard Chirurgical Writers from Hippocrates down to the present Age, we shall find, that an ulcerated Cartilage is universally allowed to be a very troublesome Disease; that it admits of a Cure with more Difficulty than carious Bone; and that, when destroyed, it is not recovered”. Up until now this sentence still dictates the vision of orthopedic surgeons how to deal with joint disorders like osteoarthritis and cartilage trauma.



Recent scientific developments have challenged the view of William Hunter. First, distraction of the joint for just 6 weeks is sufficient to stimulate complete regrowth of an eroded articular cartilage surface in animal models and human patients. Second, resident stem cell populations have been identified in joint tissue such as cartilage, the bone marrow compartment below the subchondral bone plate, the synovial membrane and freely floating in the synovial fluid. Evidence shows that these cells can migrate to cartilage defects and can be activated to induce a regenerative response. Indeed, most likely by exploiting the regenerative potential of these stem or progenitor cell populations, it was shown in preliminary experiments that focal cartilage defects can be repaired by a biomaterial approach only in orthotopic focal cartilage defect equine and rabbit models. In these animals, chondral defects were filled with an injectable in situ gelating hydrogel that activates locally resident stem or progenitor cells. Indeed in rabbits, after 10 weeks defects were completely repaired in a cell-free approach. In the equine model, histological examination demonstrated the ingrowth of cells in the hydrogel two weeks after the arthroscopically guided implantation of the hydrogel in the chondral defect. A substantial part of these cells showed typical chondrocyte features. Taken together multiple lines of evidence demonstrates that articular cartilage can repair itself once the proper microenvironment is offered which unleashes its regenerative potential.



These exciting new developments open up a complete new avenue for the treatment of focal cartilage defects and osteoarthritis. Primary osteoarthritis and secondary osteoarthritis as a consequence of cartilage trauma earlier in life are among the most prevalent diseases in the Western World for which no effective cure is available. This proposal aims at bringing together leading Dutch groups on osteoarthritis research, which are well known for their pioneering work on the potential of intrinsic cartilage repair, with Dutch SMEs active in developing innovative treatments for joint regeneration. The program is furthermore supported by the Dutch Arthritis Foundation.
Within this proposal we intend to develop multidisciplinary projects along two intrinsically related themes:



Theme 1 is focusing on studies to explore the cellular basis of intrinsic cartilage repair and the role of biomechanics: This could be either stem cell populations residing in the joint but might also be chondrocyte subpopulations or alternative cell sources. Once identified we will aim at two strategies that can exploit these cell populations: i) development of bioactive scaffolds that in a cell-free manner can induce regeneration of lost cartilage tissue by activating these resident stem or progenitor cell populations; ii) controlled release strategies that release bioactive components that activate the regenerative potential of these cells.



Theme 2 is focusing on studies to explore the molecular basis of joint homeostasis by assessing the composition of synovial fluid in opposing conditions (catabolic versus anabolic conditions). This may lead to new diagnostics but also to new drugs / biologicals that can restore joint homeostasis.



Both themes are intrinsically related. For example joint distraction changes the catabolic osteoarthritic milieu in the joint into an anabolic regenerative milieu. Likewise, cell attracting hydrogels that fill up cartilage defects induce a regenerative response while in control animals similar defects result in cartilage catabolism. These opposing experimental conditions thus provide excellent models to study the fundamentals of joint homeostasis that could lead to new biomarkers of disease as well as new therapeutic interventions.

Role Researcher Funding
NWO grant: Applied and Engineering Sciences
Project members UU
External project members:
  • dr. H.B.J. (Marcel) Karperien
  • Prof. dr. G.J. van Osch
  • Prof. dr. H. Weinans
  • Prof. dr. F. Lafeber
  • dr. P. van der Kraan
  • dr P. Emans
  • dr T. Welting
  • Dutch Arthritis Foundation
  • Hy2Care B.V.
  • InGell B.V.
  • Crystal Therapeutics B.V.
  • QVQ B.V.
  • Percuros B.V.
Project:
ArIADNE: Controlled release of Anti-Inflammatory Agents for prolonged inhibition of inflammation, pain and DegeNeration in degenerative joint diseasE
01.09.2014 to 31.12.2018
General project description 

In Western societies, osteoarthritis (OA) and chronic low back pain caused by intervertebral disc degeneration are the musculoskeletal diseases with most impact, resulting in decreased productivity and high health costs. Anti-Inflammatory Agents (AIA) are effective but have systemic side effects or limited duration of local activity. The ArIADNE consortium will develop slow release systems of anti-inflammatory drugs for the long term inhibition of inflammation, thus enhancing regeneration. Furthermore, in order to fine-tune these systems for clinical application, the local side effects of high local and prolonged doses of AIAs will be studied, as well as the in vivo release kinetics of AIA in relation to the implantation site and biomaterial degradation . Alongside, ArIADNE will study the role of inflammation in regeneration and kartogenin and caveolin-1 in particular as possible new regenerative compounds.

Role Researcher Funding
External funding: Life Sciences Health sector: Impulse
Project members UU
External project members:
  • dr LB Creemers (UMC Utrecht)
  • I Jansen (UMC Utrecht)
  • Nina Voike (DSM)
  • George Mihov (DSM)
  • Jens Thies (DSM)
  • Ingrid Lether (Dutch Arthritis Foundation)
Project:
Mimicking developmental biology to regenerate the intervertebral disc
01.01.2012 to 30.12.2017
General project description 

Low back pain is a widespread disorder, with tremendous socioeconomical impact. While this condition is multifactorial, intervertebral disc degeneration is one of its main causes. Actual treatments are only symptomatic (to alleviate pain) and new therapies are needed. Disc degeneration is characterized by the inability of the resident cells to keep the disc tissue intact due to a change of their phenotype and their decreasing number. Thus, delivery of exogenous cells may help. The disc originally contains two distinct cell populations: the nucleus pulposus cells (NPCs, chondrocyte-like cells) and the notochordal cells (NCs). Because NCs do not exist in human adults, regenerative therapies have only focused on using chondrocyte-like cells, e.g. adult mesenchymal stem cells (MSCs). However, their transplantation has been of limited success as disc degeneration was only inhibited and not reversed. We believe that this failure is in part due to inability of the transplanted cells to produce enough/appropriate disc matrix to restore tissue properties.


Using an innovative approach, we propose to mimic the natural cell combination of a developing disc, i.e. NCs and NPCs/MSCs, when the largest amount of matrix is produced. Different approaches will be tested for their efficacy using a succession of model systems moving from higher volume:cost ratio systems to more realistic but lower volume:costs systems. Another novelty of our approach will be to use the canine model in which disc degeneration is a frequent spontaneous spinal disease and whose NCs, NPCs and MSCs are readily available.


First, canine NCs, NPCs and MSCs (used to complement the decreasing disc cell population) will be combined in different co-culture systems to compare the ability of various cell combinations to stimulate the production of an appropriate disc matrix. We will also determine if the NCs directly contribute to matrix production or regulate other cells through biochemical signals. The most successful concepts will be further developed pre-clinically in experimental dogs with early stage spontaneous disc degeneration. Finally as proof of principle, a clinical study will be performed in client-owned canine patients with disc disease as the basis for a trial to be set up in human patients. In parallel with this sequential approach, the applicability of our findings to human cells will be demonstrated and if the NC regulatory effects are mediated through soluble factors, these will be identified for further exploitation. This project will (1) provide new and important insights on the role of NCs in disc regeneration and (2) may provide a new biological therapy to treat one of the most common disorders in modern society.

Role Researcher Funding
External funding: Financed by the AO Spine Research Network
Project members UU
External project members:
  • Prof. dr. Keita Ito (TU/e)
  • dr. Laura Creemers (UMCU)
  • Ing. Stefan de Vries (TU/e)
  • Ing. Irene Arkensteijn (TU/e)
  • dr. Esther Potier (TU/e)

Completed projects

Project:
New Early Therapies for Intervertebral Disc Diseases. Drug Delivery and Augmentation through Smart Polymeric Biomaterials 01.01.2009 to 30.06.2014
General project description

Do not remove…


The spinal column has a heavy task. It protects our spinal cord and its nerves, carries our body weight, supports the head and absorbs the shocks resulting from physical exercise. No wonder that lower back pain is a very common problem. Two out of three Dutch people will be confronted with this problem during their lifetime. Some people have chronic lower back pain. An important cause of chronic back pain is wear and tear of the intervertebral disc, the soft disc between the vertebrae that together form the spinal column. This degeneration of the intervertebral disc develops due to a previously incurred hernia or gradual wear and tear. Current treatments for lower back pain require the replacement of afflicted vertebrae with bone from elsewhere in the body, or replacement by intervertebral disc prostheses. In both cases, the entire intervertebral disc is removed and only the symptoms are suppressed. These operations also carry risks, such as further damage to the adjacent intervertebral disc, and persistent pain at the sites where the bone was removed.


... but repair


The purpose of this study is to determine how the function of the degenerated intervertebral disc can be repaired instead of removed. If the degeneration of a vertebral disc is not far advanced, a treatment could consist of injectable, biodegradable materials that release drugs over a longer period of time, thereby stimulating the self-recovery of the intervertebral disc. The materials for the incorporation and release of these compounds may be watery gels, very small spheres (microparticles) or a combination of these two. Next to this, methods are being developed to repair the outside of the intervertebral disc to ensure the injected materials will not diffuse out of the disc. These methods are based on a biodegradable plaster.


A unique aspect of this project is the investigation into the ethical aspects of these new self-repair methods and the moral guidelines for implementing these techniques in patients.

 
Role Researcher Funding
External funding: Funded by BMM which is financed by the Dutch government (50%), academia (25%) and industry (25%)
Project members UU
External project members:
  • dr LB Creemers
  • prof dr K Ito
  • prof dr T Smit
  • InGell BV.
  • DSM
  • TNO
Gegenereerd op 2017-11-20 07:08:31
Additional functions and activities

HD and ED committee

Gegenereerd op 2017-11-20 07:08:31
Full name
prof. dr. B.P. Meij Contact details
Prof. dr. H. Jakobgebouw

Yalelaan 108
Room 1073
3584 CM  UTRECHT
The Netherlands


Phone number (direct) +31 30 253 4701
Onbekend Gebouw

Onbekend 9999
Room 1.073
9999 AA  ONBEKEND
The Netherlands


Phone number (direct) +31 30 253 4701
Gegenereerd op 2017-11-20 07:08:31
Last updated 22.05.2015