Selected Publications
L.M. Chataigner, C. Gogou, M.A. den Boer, C.P. Frias, D.M. Thies-Weesie, J.C. Granneman, A.J. Heck, D.H. Meijer and B.J. Janssen. (2022) ‘Structural insights into the contactin 1 - neurofascin 155 adhesion complex.’ Nature Comms 13:6607 1-17
D.H. Meijer#, C.P. Frias, J.W. Beugelink, Y.N. Deurloo and B.J. Janssen#. (2022) ‘Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions.’ The EMBO Journal e107505
T.M. Wood*, M.R. Zeronian*, N. Buijs, K. Bertheussen, H.K. Abedian, A.V. Johnson, N.M. Pearce, M. Lutz, J. Kemmink, T. Seirsma, L.W. Hamoen, B.J. Janssen# and N.I. Martin#. (2022) ‘Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure-activity studies and high-resolution crystal structures.’ Chemical Science 10.1039/D1SC07190D
M.R. Zeronian*, O. Klykov*, J. Portell I de Montserrat, M.J. Konijnenberg, A. Gaur, R.A. Scheltema# and B.J. Janssen#. (2021) ‘Notch-Jagged signaling complex defined by an interaction mosaic.’ Proc Natl Acad Sci U S A. 27;118(30)
N. Leloup, L.M.P. Chataigner and B.J. Janssen. (2018) ‘Structural insights into SorCS2-Nerve Growth Factor complex formation.’ Nature Comms 9:2979 1-10
N. Leloup, P. Lössl, D.H. Meijer, M. Brennich, A.J. Heck, D.M. Thies-Weesie and B.J. Janssen. (2017) ‘Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release.’ Nature Comms 8:1708 1-16
L.H.J. Kleijn*, H.C Vlieg*, T.M. Wood, J. Sastre Toraño, B.J. Janssen# and N.I. Martin#. (2017) ‘High-resolution crystal structure reveals molecular details of target recognition by the calcium-dependent lipopeptide antibiotic laspartomycin C.’ Angew Chem Int Ed 56 16546-16549
M.F. Pronker, S. Lemstra, J. Snijder, A.J. Heck, D.M. Thies-Weesie, R.J. pasterkamp and B.J. Janssen. (2016) ‘Structural basis of myelin-associated glycoprotein adhesion and signalling.’ Nature Comms 7 1-13
Y. Kong*, B.J. Janssen*, T. Malinauskas, V.R. Vangoor, C.H. Coles, R. Kaufmann, T. Ni, R.J. Gilbert, S. Padilla-Parra, R.J. Pasterkamp and E.Y Jones. (2016) ‘Structural Basis for Plexin Activation and Regulation.’ Neuron 91 548-560
M.F. Pronker, T.G. Bos, T.H. Sharp, D.M. Thies-Weesie and B.J. Janssen. (2015) ‘Olfactomedin-1 has a V-shaped disulfide-linked tetrameric structure.’ J Biol Chem 290 15092-15101
B.J. Janssen*, T. Malinauskas*, G.A. Weir, M.Z. Cader, C. Siebold and E.Y. Jones. (2012) ‘Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.’ Nat Struct Mol Biol 19 1293-1299
B.J. Janssen*, R.A. Robinson*, F. Perez-Branguli, C.H. Bell, K.J. Mitchell, C. Siebold and E.Y. Jones. (2010) ‘Structural basis of semaphorin-plexin signalling.’ Nature 467 1118-1122
B.J. Janssen, A. Christodoulidou, A. McCarthy, J.D. Lambris and P. Gros. (2006) 'Structure of C3b reveals conformational changes that underlie complement activity.' Nature 444 213-216
B.J. Janssen, E.G. Huizinga, H.C. Raaijmakers, A. Roos, M.R. Daha, K. Nilsson-Ekdahl, B. Nilsson and P. Gros. (2005) 'Structures of complement component C3 provide insights into the function and evolution of immunity.' Nature 437 505-511
*Equal contribution, #Co-corresponding
Full publication list in PubMed
Publications
2022
Scholarly publications
Zeronian, M. R., Doulkeridou, S., Van bergen en henegouwen, P. M. P., & Janssen, B. J. C. (2022). Structural insights into the non-inhibitory mechanism of the anti-EGFR EgB4 nanobody. BMC Molecular and Cell Biology, 23(1), [12]. https://doi.org/10.1186/s12860-022-00412-x
Chataigner, L. M. P., Gogou, C., den Boer, M. A., Frias, C. P., Thies-Weesie, D. M. E., Granneman, J. C. M., Heck, A. J. R., Meijer, D. H., & Janssen, B. J. C. (2022). Structural insights into the contactin 1 - neurofascin 155 adhesion complex. Nature Communications, 13(1), [6607]. https://doi.org/10.1038/s41467-022-34302-9
Wood, T. M., Zeronian, M. R., Buijs, N., Bertheussen, K., Abedian, H. K., Johnson, A. V., Pearce, N. M., Lutz, M., Kemmink, J., Seirsma, T., Hamoen, L. W., Janssen, B. J. C., & Martin, N. I. (2022). Mechanistic insights into the C55-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures†. Chemical Science, 13(10), 2985-2991. https://doi.org/10.1039/d1sc07190d
Meijer, D. H., Frias, C. P., Beugelink, J. W., Deurloo, Y. N., & Janssen, B. J. C. (2022). Teneurin4 dimer structures reveal a calcium-stabilized compact conformation supporting homomeric trans-interactions. EMBO Journal, 41(9), [e107505]. https://doi.org/10.15252/embj.2020107505
2021
Scholarly publications
Su, X., Ramírez-Escudero, M., Sun, F., van den Dikkenberg, J. B., van Steenbergen, M. J., Pieters, R. J., Janssen, B. J. C., van Hasselt, P. M., Hennink, W. E., & van Nostrum, C. F. (2021). Internalization and transport of PEGylated lipid-based mixed micelles across Caco-2 cells mediated by scavenger receptor B1. Pharmaceutics, 13(12), 1-22. [2022]. https://doi.org/10.3390/pharmaceutics13122022
Zeronian, M. R., Klykov, O., Portell i de Montserrat, J., Konijnenberg, M. J., Gaur, A., Scheltema, R. A., & Janssen, B. J. C. (2021). Notch–Jagged signaling complex defined by an interaction mosaic. Proceedings of the National Academy of Sciences of the United States of America, 118(30), 1-12. [e2102502118]. https://doi.org/10.1073/pnas.2102502118
2020
Scholarly publications
Denisov, S. S., Ramírez-Escudero, M., Heinzmann, A. C. A., Ippel, J. H., Dawson, P. E., Koenen, R. R., Hackeng, T. M., Janssen, B. J. C., & Dijkgraaf, I. (2020). Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4. Journal of Biological Chemistry, 295(42), 14367-14378. https://doi.org/10.1074/jbc.RA120.013891
Chataigner, L. M. P., Leloup, N., & Janssen, B. J. C. (2020). Structural Perspectives on Extracellular Recognition and Conformational Changes of Several Type-I Transmembrane Receptors. Frontiers in Molecular Biosciences, 7, [129]. https://doi.org/10.3389/fmolb.2020.00129
2019
Scholarly publications
Vlieg, H. C., Huizinga, E. G., & Janssen, B. J. C. (2019). Structure and flexibility of the extracellular region of the PirB receptor. Journal of Biological Chemistry, 294(12), 4634-4643. https://doi.org/10.1074/jbc.RA118.004396
Jackson, V. A., Busby, J. N., Janssen, B. J. C., Lott, J. S., & Seiradake, E. (2019). Teneurin structures are composed of ancient bacterial protein domains. Frontiers in Neuroscience, 13, [183]. https://doi.org/10.3389/fnins.2019.00183
Pronker, M. F., Van Den Hoek, H., & Janssen, B. J. C. (2019). Design and structural characterisation of olfactomedin-1 variants as tools for functional studies. BMC Molecular and Cell Biology, 20, [50]. https://doi.org/10.1186/s12860-019-0232-1
2018
Scholarly publications
Janssen, B. J. C. (2018). Inside-out or outside-in, a new factor in MAG-mediated signaling in the nervous system: An Editorial for ‘High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1' on page 7. Journal of Neurochemistry, 147(6), 712-714. https://doi.org/10.1111/jnc.14597
Jackson, V. A., Meijer, D. H., Carrasquero, M., van Bezouwen, L. S., Lowe, E. D., Kleanthous, C., Janssen, B. J. C., & Seiradake, E. (2018). Structures of Teneurin adhesion receptors reveal an ancient fold for cell-cell interaction. Nature Communications, 9(1), [1079]. https://doi.org/10.1038/s41467-018-03460-0
Leloup, N. O. L., Chataigner, L. M. P., & Janssen, B. J. C. (2018). Structural Insights into SorCS2-Nerve Growth Factor complex formation. Nature Communications, 9, [2979]. https://doi.org/10.1038/s41467-018-05405-z
2017
Scholarly publications
Pronker, M. F., Tas, R. P., Vlieg, H. C., & Janssen, B. J. C. (2017). Nogo Receptor crystal structures with a native disulfide pattern suggest a novel mode of self-interaction. Acta Crystallographica Section D Structural Biology, 73(11), 860-876. https://doi.org/10.1107/S2059798317013791
Kleijn, L. H. J., Vlieg, H. C., Wood, T. M., Sastre Torano, J., Janssen, B. J. C., & Martin, N. I. (2017). A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C. Angewandte Chemie-International Edition, 56(52), 16546-16549. https://doi.org/10.1002/anie.201709240
Leloup, N., Lössl, P., Meijer, D. H., Brennich, M., Heck, A. J. R., Thies-Weesie, D. M. E., & Janssen, B. J. C. (2017). Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release. Nature Communications, 8(1), 1708. https://doi.org/10.1038/s41467-017-01485-5
2016
Scholarly publications
Pronker, M. F., Lemstra, S., Snijder, J., Heck, A. J. R., Thies - Weesie, D., Pasterkamp, R. J., & Janssen, B. J. C. (2016). Structural basis of myelin-associated glycoprotein adhesion and signalling. Nature Communications, 7, 1-13. [13584]. https://doi.org/10.1038/ncomms13584
Van 't Veer, I. L., Leloup, N., Egan, A., Janssen, B., Martin, N., Vollmer, W., & Breukink, E. (2016). Site specific immobilization of the peptidoglycan synthase PBP1B on a surface plasmon resonance chip surface. ChemBioChem, 17(23), 2250-2256. https://doi.org/10.1002/cbic.201600461
Kong, Y., Janssen, B. J. C., Malinauskas, T., Vangoor, V. R., Coles, C. H., Kaufmann, R., Ni, T., Gilbert, R. J. C., Padilla-Parra, S., Pasterkamp, R. J., & Jones, E. Y. (2016). Structural Basis for Plexin Activation and Regulation. Neuron, 91(3), 548-560. https://doi.org/10.1016/j.neuron.2016.06.018
Burgers, P. P., Bruystens, J., Burnley, R. J., Nikolaev, V. O., Keshwani, M., Wu, J., Janssen, B. J. C., Taylor, S. S., Heck, A. J. R., & Scholten, A. (2016). Structure of smAKAP and its regulation by PKA-mediated phosphorylation. The FEBS journal, 283(11), 2132-2148. https://doi.org/10.1111/febs.13726
2015
Scholarly publications
Pronker, M. F., Bos, T. G. A. A., Sharp, T. H., Thies-Weesie, D. M. E., & Janssen, B. J. C. (2015). Olfactomedin-1 has a V-shaped disulfide-linked tetrameric structure. Journal of Biological Chemistry, 290(24), 15092-15101. https://doi.org/10.1074/jbc.M115.653485
2012
Scholarly publications
Janssen, B. J. C., Malinauskas, T., Wier, G. A., Cader, M. Z., Siebold, C., & Jones, E. Y. (2012). Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature Structural and Molecular Biology, 19, 1293-1299. https://doi.org/10.1038/nsmb.2416
2010
Scholarly publications
Janssen, B. J. C., Robinson, R. A., Pérez-Brangulí, F., Bell, C. H., Mitchell, K. J., Siebold, C., & Jones, E. Y. (2010). Structural basis of semaphorin-plexin signalling. Nature, 467(7319), 1118-22. https://doi.org/10.1038/nature09468
2009
Scholarly publications
Fritzinger, D. C., Hew, B. E., Thorne, M., Pangburn, M. K., Gros, P., Janssen, B. J. C., & Vogel, C. W. (2009). Functional characterization of human C3/cobra venom factor hybrid proteins for therapeutic complement depletion. Developmental and Comparative Immunology, 33(1), 105-116. https://doi.org/10.1016/j.dci.2008.07.006
Janssen, B. J. C., Gomes, L., Koning, R. I., Svergun, D. I., Koster, A. J., Fritzinger, D. C., Vogel, C. W., & Gros, P. (2009). Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex. EMBO Journal, 28(16), 2469-2478. https://doi.org/10.1038/emboj.2009.184
Wu, J., Wu, Y., Ricklin, D., Janssen, B. J. C., Lambris, J. D., & Gros, P. (2009). Structure of complement fragment C3b–factor H and implications for host protection by complement regulators. Nature Immunology, 10(7), 728-733. https://doi.org/10.1038/ni.1755
Rooijakkers, S. H. M., Wu, J., Ruyken, M., van Domselaar, R., Planken, K. L., Tzekou, A., Ricklin, D., Lambris, J. D., Janssen, B. J., van Strijp, J. A. G., & Gros, P. (2009). Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor. Nature Immunology, 10(7), 721-727. http://www.ncbi.nlm.nih.gov/pubmed/19503103
2008
Scholarly publications
Gros, P., Milder, F. J., & Janssen, B. J. C. (2008). Complement driven by conformational changes. Nature Reviews. Immunology, 8(1), 48-58. https://doi.org/10.1038/nri2231
Frémeaux-Bacchi, V., Miller, E. C., Liszewski, M. K., Strain, L., Blouin, J., Brown, A. L., Moghal, N., Kaplan, B. S., Weiss, R. A., Lhotta, K., Kapur, G., Mattoo, T., Nivet, H., Wong, W., Gie, S., Hurault de Ligny, B., Fischbach, M., Gupta, R., Hauhart, R., ... Atkinson, J. P. (2008). Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood, 112(13), 4948-52. https://doi.org/10.1182/blood-2008-01-133702
2007
Scholarly publications
Janssen, B. J. C., Read, R. J., Brünger, A. T., & Gros, P. (2007). Crystallography: Crystallographic evidence for deviating C3b structure. Nature, 448(7154). https://doi.org/10.1038/nature06102
2006
Scholarly publications
Janssen, B. J. C., & Gros, P. (2006). Conformational complexity of complement component C3. Advances in Experimental Medicine and Biology, 586, 291-312. https://doi.org/10.1007/0-387-34134-X_20
2003
Scholarly publications
Janssen, B. J. C., Schirra, H. J., Lay, F. T., Anderson, M. A., & Craik, D. J. (2003). Structure of Petunia hybrida defensin 1, a novel plant defensin with five disulfide bonds. Biochemistry, 42(27), 8214-22. https://doi.org/10.1021/bi034379o