Publications
2023
Scholarly publications
van Dijk, A., Guabiraba, R., Bailleul, G., Schouler, C., Haagsman, H. P., & Lalmanach, A-C. (2023). Evolutionary diversification of defensins and cathelicidins in birds and primates. Molecular Immunology, 157, 53-69. https://doi.org/10.1016/j.molimm.2023.03.011
Kunchala, S. R., van Dijk, A., Veldhuizen, E. J. A., Donnellan, S. C., Haagsman, H. P., & Orgeig, S. (2023). Avian surfactant protein (SP)-A2 first arose in an early tetrapod before the divergence of amphibians and gradually lost the collagen domain. Developmental and Comparative Immunology, 139, 1-14. [104582]. https://doi.org/10.1016/j.dci.2022.104582
2022
Scholarly publications
van Dijk, A., Anten, J., Bakker, A., Evers, N., Hoekstra, A. T., Chang, J-C., Scheenstra, M. R., Veldhuizen, E. J. A., Netea, M. G., Berkers, C. R., & Haagsman, H. P. (2022). Innate Immune Training of Human Macrophages by Cathelicidin Analogs. Frontiers in Immunology, 13, 1-18. [777530]. https://doi.org/10.3389/fimmu.2022.777530
van Os, N., Javed, A., Broere, F., van Dijk, A., Balhuizen, M. D., van Eijk, M., Rooijakkers, S. H. M., Bardoel, B. W., Heesterbeek, D. A. C., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Novel insights in antimicrobial and immunomodulatory mechanisms of action of PepBiotics CR-163 and CR-172. Journal of Global Antimicrobial Resistance, 30, 406-413. https://doi.org/10.1016/j.jgar.2022.07.009
Harten, R. M. V., Bokhoven, J. L. M. T., Greeff, A. D., Balhuizen, M. D., Dijk, A. V., Veldhuizen, E. J. A., Haagsman, H. P., & Scheenstra, M. R. (2022). d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2. Journal of Advanced Research, 36, 101-112. https://doi.org/10.1016/j.jare.2021.05.009
Verheije, M. H., Coorens, M., Weerts, E. A. W. S., Berends, A. J., van Harten, R. M., Angel, M., Kooij, J., Ordonez, S. R., van Beurden, S. J., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Antiviral activity of selected cathelicidins against infectious bronchitis virus. Peptide Science, 114(1), 1-8. [e24234]. https://doi.org/10.1002/pep2.24234
2021
Scholarly publications
Balhuizen, M. D., van Dijk, A., Jansen, J. W. A., van de Lest, C. H. A., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides. mSphere, 6(4), 1-14. [e0052321]. https://doi.org/10.1128/mSphere.00523-21
van Eijk, M., van Dijk, A., van der Ent, C. K., Arets, H. G. M., Breukink, E., van Os, N., Adrichem, R., van der Water, S., Gomez, R. L., Kristensen, M., Hessing, M., Jekhmane, S., Weingarth, M., Veldhuizen, R. A. W., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections. Biochimica et Biophysica Acta - General Subjects, 1865(9), [129951]. https://doi.org/10.1016/j.bbagen.2021.129951
2020
Scholarly publications
Kraaij, M. D., van Dijk, A., Scheenstra, M. R., van Harten, R. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). Chicken CATH-2 increases antigen presentation markers on chicken monocytes and macrophages. Protein and Peptide Letters, 27(1), 60-66. https://doi.org/10.2174/0929866526666190730125525
https://dspace.library.uu.nl/bitstream/handle/1874/389132/Kraaij_et_al_revised.docx?sequence=3
https://dspace.library.uu.nl/bitstream/handle/1874/389132/Kraaij_et_al_revised.docx?sequence=3
2019
Scholarly publications
Scheenstra, M. R., van den Belt, M., Tjeerdsma-van Bokhoven, J. L. M., Schneider, V. A. F., Ordonez, S. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2019). Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Scientific Reports, 9(1), 4780. https://doi.org/10.1038/s41598-019-41246-6
2018
Scholarly publications
van Harten, R. M., van Woudenbergh, E., van Dijk, A., & Haagsman, H. P. (2018). Cathelicidins: Immunomodulatory Antimicrobials. Vaccines, 6(3), [63]. https://doi.org/10.3390/vaccines6030063
van Dijk, A., Hedegaard, C. J., Haagsman, H. P., & Heegaard, P. M. H. (2018). The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production. Veterinary Research, 49(1), [68]. https://doi.org/10.1186/s13567-018-0558-2
Cuperus, T., Kraaij, M. D., Zomer, A. L., van Dijk, A., & Haagsman, H. P. (2018). Immunomodulation and effects on microbiota after in ovo administration of chicken cathelicidin-2. PLoS One, 13(6), [e0198188]. https://doi.org/10.1371/journal.pone.0198188
Gao, J., Scheenstra, M. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2018). A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages. Veterinary Immunology and Immunopathology, 200, 7-15. https://doi.org/10.1016/j.vetimm.2018.04.002
2017
Scholarly publications
Bosso, A., Pirone, L., Gaglione, R., Pane, K., Del Gatto, A., Zaccaro, L., Di Gaetano, S., Diana, D., Fattorusso, R., Pedone, E., Cafaro, V., Haagsman, H. P., van Dijk, A., Scheenstra, M. R., Zanfardino, A., Crescenzi, O., Arciello, A., Varcamonti, M., Veldhuizen, E. J. A., ... Pizzo, E. (2017). A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence. Biochimica et Biophysica Acta - General Subjects, 1861(9), 2342-2353. https://doi.org/10.1016/j.bbagen.2017.04.009
Coorens, M., Schneider, V. A. F., de Groot, A. M., van Dijk, A., Meijerink, M., Wells, J. M., Scheenstra, M. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner. Journal of Immunology, 199(4), 1418-1428. https://doi.org/10.4049/jimmunol.1602164
Kraaij, M. D., van Dijk, A., & Haagsman, H. P. (2017). CATH-2 and LL-37 increase mannose receptor expression, antigen presentation and the endocytic capacity of chicken mononuclear phagocytes. Molecular Immunology, 90, 118-125. https://doi.org/10.1016/j.molimm.2017.07.005
Coorens, M., Banaschewski, B. J. H., Baer, B. J., Yamashita, C. M., van Dijk, A., Haagsman, H. P., Veldhuizen, R. A. W., & Veldhuizen, E. J. A. (2017). Killing of Pseudomonas aeruginosa by chicken cathelicidin-2 is immunogenically silent, preventing lung inflammation in vivo. Infection and Immunity, 58(12), [e00546-17]. https://doi.org/10.1128/IAI.00546-17
Schneider, V. A. F., Coorens, M., Tjeerdsma-van Bokhoven, J. L. M., Posthuma, G., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response. mSphere, 2(6), [e00370-17]. https://doi.org/10.1128/mSphere.00370-17
Veldhuizen, E. J. A., Scheenstra, M. R., Tjeerdsma-van Bokhoven, J. L. M., Coorens, M., Schneider, V. A. F., Bikker, F. J., van Dijk, A., & Haagsman, H. P. (2017). Antimicrobial and immunomodulatory activity of PMAP-23 derived peptides. Protein and Peptide Letters, 24(7). https://doi.org/10.2174/0929866524666170428150925
Zhang, W., van Eijk, M., Guo, H., van Dijk, A., Bleijerveld, O. B., Verheije, M. H., Wang, G., Haagsman, H. P., & Veldhuizen, E. J. A. (2017). Expression and characterization of recombinant chicken mannose binding lectin. Immunobiology, 222(3), 518-528. https://doi.org/10.1016/j.imbio.2016.10.019
Other output
van Eijk, M., van der Ent, C. K., Aerts, H. G., Kristensen, M. I., de Cock, H., van Dijk, A., Keijzer, B. J., & Haagsman, H. P. (2017). Novel antimicrobial peptides to fight infections in patients with cystic fibrosis. S13. https://doi.org/10.1016/S1569-1993(17)30198-4
2016
Scholarly publications
Schneider, V. A. F., Coorens, M., Posthuma, G., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Imaging the antimicrobial mechanism(s) of cathelicidin-2. Scientific Reports, 6, [32948]. https://doi.org/10.1038/srep32948
Rodriguez-Lecompte, J. C., Yitbarek, A., Cuperus, T., Echeverry, H., & van Dijk, A. (2016). The immunomodulatory effect of vitamin D in chickens is dose-dependent and influenced by calcium and phosphorus levels. Poultry Science, 95(11), 2547-2556. https://doi.org/10.3382/ps/pew186
Cuperus, T., van Dijk, A., Matthijs, M. G. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli. Scientific Reports, 6, [26622]. https://doi.org/10.1038/srep26622
Zhang, W., Cuperus, T., van Dijk, A., Skjødt, K., Hansen, S., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Developmental regulation of chicken surfactant protein A and its localization in lung. Developmental and Comparative Immunology, 61, 80-87. https://doi.org/10.1016/j.dci.2016.03.010
Cuperus, T., van Dijk, A., Dwars, R. M., & Haagsman, H. P. (2016). Localization and developmental expression of two chicken host defense peptides: Cathelicidin-2 and avian β-defensin 9. Developmental and Comparative Immunology, 61, 48-59. https://doi.org/10.1016/j.dci.2016.03.008
Schneider, V. A. F., van Dijk, A., van der Sar, A. M., Kraaij, M. D., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity. Developmental and Comparative Immunology, 60, 108-114. https://doi.org/10.1016/j.dci.2016.02.023
van Dijk, A., van Eldik, M., Veldhuizen, E. J. A., Tjeerdsma-van Bokhoven, H. L. M., de Zoete, M. R., Bikker, F. J., & Haagsman, H. P. (2016). Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides. PLoS One, 11(2), [e0147919]. https://doi.org/10.1371/journal.pone.0147919
2015
Scholarly publications
Coorens, M., van Dijk, A., Bikker, F., Veldhuizen, E. J. A., & Haagsman, H. P. (2015). Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation. Journal of Immunology, 195(8), 3970-3977. https://doi.org/10.4049/jimmunol.1501242
Other output
Haagsman, H. P., van Dijk, A., & Veldhuizen, E. J. A. (2015). New CATH-2 derivatives. (Patent No. WO2015/170984).
2014
Scholarly publications
Veldhuizen, E. J. A., Schneider, V. A. F., Agustiandari, H., Van Dijk, A., Tjeerdsma - van Bokhoven, J. L. M., Bikker, F. J., & Haagsman, H. P. (2014). Antimicrobial and immunomodulatory activities of PR-39 derived peptides. PLoS One, 9(4), [e95939]. https://doi.org/10.1371/journal.pone.0095939
Other output
Haagsman, H., van Dijk, A., & Veldhuizen, E. (Accepted/In press). New CATH-2 derivatives. (Patent No. EP 14167718.7).
2013
Scholarly publications
Cuperus, T., Coorens, M., van Dijk, A., & Haagsman, H. P. (2013). Avian host defense peptides. Developmental and Comparative Immunology, 41, 352-369. https://doi.org/10.1016/j.dci.2013.04.019
2012
Scholarly publications
van Dijk, A., Herrebout, M., Tersteeg-Zijderveld, M. H. G., Tjeerdsma-van Bokhoven, J. L. M., Bleumink-Pluym, N., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2012). Campylobacter jejuni is highly susceptible to killing by chicken host defense peptide cathelicidin-2 and suppresses intestinal cathelicidin-2 expression in young broilers. Veterinary Microbiology, 160(3-4), 347-354. https://doi.org/10.1016/j.vetmic.2012.05.034
Other output
Bikker, F. J., van Dijk, A., Mars-Groenendijk, R., Veldhuizen, E., van der Kleij, D., Haagsman, H., & Molhoek, E. M. (2012). Antimicrobial peptides based on CMAP27. (Patent No. US-2012-0093844-A1).
2011
Scholarly publications
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). A cathelicidin-2-derived peptide effectively impairs Staphylococcus epidermidis biofilms. International Journal of Antimicrobial Agents, 37, 476-479. https://doi.org/10.1016/j.ijantimicag.2010.12.020
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization. Peptides, 32(5), 875-880. https://doi.org/10.1016/j.peptides.2011.02.017
van Dijk, A., Molhoek, E. H., Bikker, F. J., Yu, P. L., Veldhuizen, E. J. A., & Haagsman, H. P. (2011). Avian cathelicidins: Paradigms for the development of anti-infectives. Veterinary Microbiology, 153, 27-36.
2010
Scholarly publications
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Dijk-Knijnenburg, H., Mars-Groenendijk, R. H., Boele, L. C., Kaman-van Zanten, W. E., Haagsman, H. P., & Bikker, F. J. (2010). Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents. International Journal of Antimicrobial Agents, 36(3), 271-274. https://doi.org/10.1016/j.ijantimicag.2010.06.001
2009
Scholarly publications
van Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis. Molecular Immunology, 46(13), 2449-55. https://doi.org/10.1016/j.molimm.2009.05.028
Veldhuizen, E. J. A., Koomen, I., Ultee, A., van Dijk, A., & Haagsman, H. P. (2009). Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line. Veterinary Microbiology, 136, 69-75.
van Dijk, A., Tersteeg-Zijderveld, H. G., Tjeerdsma-van Bokhoven, J. L. M., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2009). Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS. Molecular Immunology, 46, 1517-1526.
Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of -defensins in dogs with atopic dermatitis. Molecular Immunology, 46, 2449-2455.
van Dijk, A., Molhoek, E. M., Veldhuizen, E. J. A., Tjeerdsma - van Bokhoven, H., Wagendorp, E., Bikker, F., & Haagsman, H. P. (2009). Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities. Molecular Immunology, 46, 2465-2473.
Professional publications
van Dijk, A. (2009). Antimicrobiële peptiden van de kip: biologische functies en mogelijke toepassingen. Tijdschrift voor Diergeneeskunde, 134, 282-284.
2008
Scholarly publications
Veldhuizen, E. J. A., Rijnders, M., Claassen, E. A., van Dijk, A., & Haagsman, H. P. (2008). Porcine ß-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Molecular Immunology, 45, 386-394.
van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2008). Avian defensins. Veterinary Immunology and Immunopathology, 124, 1-18.
2007
Scholarly publications
Veldhuizen, E. J. A., van Dijk, A., Tersteeg, M. H., Kalkhove, S. I. C., van der Meulen, J., Niewold, T. A., & Haagsman, H. P. (2007). Expression of β-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection. Molecular Immunology, 44(4), 276-283.
https://dspace.library.uu.nl/bitstream/handle/1874/26132/veldhuizen%2520et%2520al%25202007.pdf?sequence=2
https://dspace.library.uu.nl/bitstream/handle/1874/26132/veldhuizen%2520et%2520al%25202007.pdf?sequence=2
van Dijk, A. (2007). Chicken antimicrobial peptides: biological functions and possible applications. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Gildeprint Drukkerijen Enschede.
van Dijk, A., Veldhuizen, E. J. A., Kalkhove, S. I. C., Tjeerdsma-van Bokhoven, J. L. M., Romijn, R. A., & Haagsman, H. P. (2007). The β-defensin gallinacin-6 is expressed in the chicken digestive tract and has antimicrobial activity against food-borne pathogens. Antimicrobial Agents and Chemotherapy, 51(3), 912-922.
https://dspace.library.uu.nl/bitstream/handle/1874/309938/van_Dijk_et_al_2007.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/309938/van_Dijk_et_al_2007.pdf?sequence=1
2006
Scholarly publications
Hogenkamp, A., van Eijk, M., van Dijk, A., van Asten, A. J., Veldhuizen, E. J. A., & Haagsman, H. P. (2006). Characterization and expression sites of newly identified chicken collectins. Molecular Immunology, 43(10), 1604-1606.
Veldhuizen, E. J. A., Hendriks, H. G. C. J. M., Hogenkamp, A., van Dijk, A., Gaastra, W., Tooten, P. C. J., & Haagsman, H. P. (2006). Differential regulation of porcine beta-defensins 1 and 2 upon Salmonella infection in the intestinal epithelial cell line IPI-2I. Veterinary Immunology and Immunopathology, 114(1-2), 94-102. https://doi.org/10.1016/j.vetimm.2006.07.012
2005
Scholarly publications
van Dijk, A., Veldhuizen, E. J. A., van Asten, A. J. A. M., & Haagsman, H. P. (2005). CMAP27, a novel chicken cathelicidin-like antimicrobial protein. Veterinary Immunology and Immunopathology, 106, 321-327.
2002
Scholarly publications
Houben, J. H., van Dijk, A., & Eikelenboom, G. (2002). Dietary vitamin E supplementation, and ascorbic acid preparation, and packaging effects on colour stability and lipid oxidation in mince made from previously frozen lean beef. European Food Research and Technology, 214, 186-191.
2001
Scholarly publications
Houben, J. H., & van Dijk, A. (2001). Effects of dietary vitamin E supplementation and packaging on the colour stability of sliced pasteurized beef ham. Meat Science, 58, 403-407.
2000
Scholarly publications
Houben, J. H., van Dijk, A., Eikelenboom, G., & Hoving-Bolink, A. H. (2000). Effect of dietary vitamin E supplementation, fat level and packaging on colour stability and lipid oxidation in minced beef. Meat Science, 55, 331-336.
Klont, R. E., Barnier, V. H. M., van Dijk, A., Smulders, F. J. M., Hoving-Bolink, A. H., Hulsegge, B., & Eikelenboom, G. (2000). Effects of rate of pH fall, time of deboning, aging period, and their interaction on veal quality characteristics. Journal of Animal Science, 78, 1845-1851.