Publications
2025
Scholarly publications
Kunchala, S. R., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Orgeig, S. (2025). Adaptation and conservation of CL-10/11 in avian lungs: implications for their role in pulmonary innate immune protection. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 380(1920), Article 20230425. [DOI] [Portal]
2023
Scholarly publications
van Dijk, A., Guabiraba, R., Bailleul, G., Schouler, C., Haagsman, H. P., & Lalmanach, A.-C. (2023). Evolutionary diversification of defensins and cathelicidins in birds and primates. Molecular Immunology, 157, 53-69. [DOI] [Repository]
Kunchala, S. R., van Dijk, A., Veldhuizen, E. J. A., Donnellan, S. C., Haagsman, H. P., & Orgeig, S. (2023). Avian surfactant protein (SP)-A2 first arose in an early tetrapod before the divergence of amphibians and gradually lost the collagen domain. Developmental and Comparative Immunology, 139, 1-14. Article 104582. [DOI] [Repository]
2022
Scholarly publications
van Dijk, A., Anten, J., Bakker, A., Evers, N., Hoekstra, A. T., Chang, J.-C., Scheenstra, M. R., Veldhuizen, E. J. A., Netea, M. G., Berkers, C. R., & Haagsman, H. P. (2022). Innate Immune Training of Human Macrophages by Cathelicidin Analogs. Frontiers in Immunology, 13, 1-18. Article 777530. [DOI] [Repository]
van Os, N., Javed, A., Broere, F., van Dijk, A., Balhuizen, M. D., van Eijk, M., Rooijakkers, S. H. M., Bardoel, B. W., Heesterbeek, D. A. C., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Novel insights in antimicrobial and immunomodulatory mechanisms of action of PepBiotics CR-163 and CR-172. Journal of Global Antimicrobial Resistance, 30, 406-413. [DOI] [Repository]
Harten, R. M. V., Bokhoven, J. L. M. T., Greeff, A. D., Balhuizen, M. D., Dijk, A. V., Veldhuizen, E. J. A., Haagsman, H. P., & Scheenstra, M. R. (2022). d-enantiomers of CATH-2 enhance the response of macrophages against Streptococcus suis serotype 2. Journal of Advanced Research, 36, 101-112. [DOI] [Repository]
Verheije, M. H., Coorens, M., Weerts, E. A. W. S., Berends, A. J., van Harten, R. M., Angel, M., Kooij, J., Ordonez, S. R., van Beurden, S. J., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2022). Antiviral activity of selected cathelicidins against infectious bronchitis virus. Peptide Science, 114(1), 1-8. Article e24234. [DOI] [Repository]
2021
Scholarly publications
Balhuizen, M. D., van Dijk, A., Jansen, J. W. A., van de Lest, C. H. A., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). Outer Membrane Vesicles Protect Gram-Negative Bacteria against Host Defense Peptides. mSphere, 6(4), 1-14. Article e0052321. [DOI] [Repository]
van Eijk, M., van Dijk, A., van der Ent, C. K., Arets, H. G. M., Breukink, E., van Os, N., Adrichem, R., van der Water, S., Gomez, R. L., Kristensen, M., Hessing, M., Jekhmane, S., Weingarth, M., Veldhuizen, R. A. W., Veldhuizen, E. J. A., & Haagsman, H. P. (2021). PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections. Biochimica et Biophysica Acta - General Subjects, 1865(9), Article 129951. [DOI] [Repository]
2020
Scholarly publications
Kraaij, M. D., van Dijk, A., Scheenstra, M. R., van Harten, R. M., Haagsman, H. P., & Veldhuizen, E. J. A. (2020). Chicken CATH-2 increases antigen presentation markers on chicken monocytes and macrophages. Protein and Peptide Letters, 27(1), 60-66. [DOI] [Repository]
2019
Scholarly publications
Scheenstra, M. R., van den Belt, M., Tjeerdsma-van Bokhoven, J. L. M., Schneider, V. A. F., Ordonez, S. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2019). Cathelicidins PMAP-36, LL-37 and CATH-2 are similar peptides with different modes of action. Scientific Reports, 9(1), 4780. [DOI] [Repository]
2018
Scholarly publications
van Harten, R. M., van Woudenbergh, E., van Dijk, A., & Haagsman, H. P. (2018). Cathelicidins: Immunomodulatory Antimicrobials. Vaccines, 6(3), Article 63. [DOI] [Repository]
van Dijk, A., Hedegaard, C. J., Haagsman, H. P., & Heegaard, P. M. H. (2018). The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production. Veterinary Research, 49(1), Article 68. [DOI] [Repository]
Cuperus, T., Kraaij, M. D., Zomer, A. L., van Dijk, A., & Haagsman, H. P. (2018). Immunomodulation and effects on microbiota after in ovo administration of chicken cathelicidin-2. PLoS One, 13(6), Article e0198188. [DOI] [Repository]
Gao, J., Scheenstra, M. R., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2018). A new and efficient culture method for porcine bone marrow-derived M1- and M2-polarized macrophages. Veterinary Immunology and Immunopathology, 200, 7-15. [DOI] [Repository]
2017
Scholarly publications
Bosso, A., Pirone, L., Gaglione, R., Pane, K., Del Gatto, A., Zaccaro, L., Di Gaetano, S., Diana, D., Fattorusso, R., Pedone, E., Cafaro, V., Haagsman, H. P., van Dijk, A., Scheenstra, M. R., Zanfardino, A., Crescenzi, O., Arciello, A., Varcamonti, M., Veldhuizen, E. J. A., ... Pizzo, E. (2017). A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence. Biochimica et Biophysica Acta - General Subjects, 1861(9), 2342-2353. [DOI] [Repository]
Coorens, M., Schneider, V. A. F., de Groot, A. M., van Dijk, A., Meijerink, M., Wells, J. M., Scheenstra, M. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Cathelicidins Inhibit Escherichia coli-Induced TLR2 and TLR4 Activation in a Viability-Dependent Manner. Journal of Immunology, 199(4), 1418-1428. [DOI] [Repository]
Kraaij, M. D., van Dijk, A., & Haagsman, H. P. (2017). CATH-2 and LL-37 increase mannose receptor expression, antigen presentation and the endocytic capacity of chicken mononuclear phagocytes. Molecular Immunology, 90, 118-125. [DOI] [Repository]
Coorens, M., Banaschewski, B. J. H., Baer, B. J., Yamashita, C. M., van Dijk, A., Haagsman, H. P., Veldhuizen, R. A. W., & Veldhuizen, E. J. A. (2017). Killing of Pseudomonas aeruginosa by chicken cathelicidin-2 is immunogenically silent, preventing lung inflammation in vivo. Infection and Immunity, 58(12), Article e00546-17. [DOI] [Repository]
Schneider, V. A. F., Coorens, M., Tjeerdsma-van Bokhoven, J. L. M., Posthuma, G., van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2017). Imaging the Antistaphylococcal Activity of CATH-2: Mechanism of Attack and Regulation of Inflammatory Response. mSphere, 2(6), Article e00370-17. [DOI] [Repository]
Zhang, W., van Eijk, M., Guo, H., van Dijk, A., Bleijerveld, O. B., Verheije, M. H., Wang, G., Haagsman, H. P., & Veldhuizen, E. J. A. (2017). Expression and characterization of recombinant chicken mannose binding lectin. Immunobiology, 222(3), 518-528. [DOI] [Repository]
Other output
van Eijk, M., van der Ent, C. K., Aerts, H. G., Kristensen, M. I., de Cock, H., van Dijk, A., Keijzer, B. J., & Haagsman, H. P. (2017). Novel antimicrobial peptides to fight infections in patients with cystic fibrosis. S13. [DOI]
2016
Scholarly publications
Schneider, V. A. F., Coorens, M., Posthuma, G., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Imaging the antimicrobial mechanism(s) of cathelicidin-2. Scientific Reports, 6, Article 32948. [DOI] [Repository]
Rodriguez-Lecompte, J. C., Yitbarek, A., Cuperus, T., Echeverry, H., & van Dijk, A. (2016). The immunomodulatory effect of vitamin D in chickens is dose-dependent and influenced by calcium and phosphorus levels. Poultry Science, 95(11), 2547-2556. [DOI] [Repository]
Cuperus, T., van Dijk, A., Matthijs, M. G. R., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli. Scientific Reports, 6, Article 26622. [DOI] [Repository]
Zhang, W., Cuperus, T., van Dijk, A., Skjødt, K., Hansen, S., Haagsman, H. P., & Veldhuizen, E. J. A. (2016). Developmental regulation of chicken surfactant protein A and its localization in lung. Developmental and Comparative Immunology, 61, 80-87. [DOI] [Repository]
Cuperus, T., van Dijk, A., Dwars, R. M., & Haagsman, H. P. (2016). Localization and developmental expression of two chicken host defense peptides: Cathelicidin-2 and avian β-defensin 9. Developmental and Comparative Immunology, 61, 48-59. [DOI] [Repository]
Schneider, V. A. F., van Dijk, A., van der Sar, A. M., Kraaij, M. D., Veldhuizen, E. J. A., & Haagsman, H. P. (2016). Prophylactic administration of chicken cathelicidin-2 boosts zebrafish embryonic innate immunity. Developmental and Comparative Immunology, 60, 108-114. [DOI] [Repository]
van Dijk, A., van Eldik, M., Veldhuizen, E. J. A., Tjeerdsma-van Bokhoven, H. L. M., de Zoete, M. R., Bikker, F. J., & Haagsman, H. P. (2016). Immunomodulatory and Anti-Inflammatory Activities of Chicken Cathelicidin-2 Derived Peptides. PLoS One, 11(2), Article e0147919. [DOI] [Repository]
2015
Scholarly publications
Coorens, M., van Dijk, A., Bikker, F., Veldhuizen, E. J. A., & Haagsman, H. P. (2015). Importance of Endosomal Cathelicidin Degradation To Enhance DNA-Induced Chicken Macrophage Activation. Journal of Immunology, 195(8), 3970-3977. [DOI] [Repository]
Other output
Haagsman, H. P., van Dijk, A., & Veldhuizen, E. J. A. (2015). New CATH-2 derivatives. (Patent No. WO2015/170984).
2014
Scholarly publications
Veldhuizen, E. J. A., Schneider, V. A. F., Agustiandari, H., Van Dijk, A., Tjeerdsma - van Bokhoven, J. L. M., Bikker, F. J., & Haagsman, H. P. (2014). Antimicrobial and immunomodulatory activities of PR-39 derived peptides. PLoS One, 9(4), Article e95939. [DOI] [Repository]
Other output
Haagsman, H., van Dijk, A., & Veldhuizen, E. (Accepted/In press). New CATH-2 derivatives. (Patent No. EP 14167718.7).
2013
Scholarly publications
Cuperus, T., Coorens, M., van Dijk, A., & Haagsman, H. P. (2013). Avian host defense peptides. Developmental and Comparative Immunology, 41, 352-369. [DOI]
2012
Scholarly publications
van Dijk, A., Herrebout, M., Tersteeg-Zijderveld, M. H. G., Tjeerdsma-van Bokhoven, J. L. M., Bleumink-Pluym, N., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2012). Campylobacter jejuni is highly susceptible to killing by chicken host defense peptide cathelicidin-2 and suppresses intestinal cathelicidin-2 expression in young broilers. Veterinary Microbiology, 160(3-4), 347-354. [DOI]
Other output
Bikker, F. J., van Dijk, A., Mars-Groenendijk, R., Veldhuizen, E., van der Kleij, D., Haagsman, H., & Molhoek, E. M. (2012). Antimicrobial peptides based on CMAP27. (Patent No. US-2012-0093844-A1).
2011
Scholarly publications
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). A cathelicidin-2-derived peptide effectively impairs Staphylococcus epidermidis biofilms. International Journal of Antimicrobial Agents, 37, 476-479. [DOI]
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Haagsman, H. P., & Bikker, F. J. (2011). Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization. Peptides, 32(5), 875-880. [DOI]
van Dijk, A., Molhoek, E. H., Bikker, F. J., Yu, P. L., Veldhuizen, E. J. A., & Haagsman, H. P. (2011). Avian cathelicidins: Paradigms for the development of anti-infectives. Veterinary Microbiology, 153, 27-36.
2010
Scholarly publications
Molhoek, E. M., van Dijk, A., Veldhuizen, E. J. A., Dijk-Knijnenburg, H., Mars-Groenendijk, R. H., Boele, L. C., Kaman-van Zanten, W. E., Haagsman, H. P., & Bikker, F. J. (2010). Chicken cathelicidin-2-derived peptides with enhanced immunomodulatory and antibacterial activities against biological warfare agents. International Journal of Antimicrobial Agents, 36(3), 271-274. [DOI]
2009
Scholarly publications
van Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of beta-defensins in dogs with atopic dermatitis. Molecular Immunology, 46(13), 2449-55. [DOI]
Veldhuizen, E. J. A., Koomen, I., Ultee, A., van Dijk, A., & Haagsman, H. P. (2009). Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line. Veterinary Microbiology, 136, 69-75.
van Dijk, A., Tersteeg-Zijderveld, H. G., Tjeerdsma-van Bokhoven, J. L. M., Jansman, A. J. M., Veldhuizen, E. J. A., & Haagsman, H. P. (2009). Chicken heterophils are recruited to the site of Salmonella infection and release antibacterial mature Cathelicidin-2 upon stimulation with LPS. Molecular Immunology, 46, 1517-1526.
Damme, C. M. M., Willemse, T., van Dijk, A., Haagsman, H. P., & Veldhuizen, E. J. A. (2009). Altered cutaneous expression of -defensins in dogs with atopic dermatitis. Molecular Immunology, 46, 2449-2455.
van Dijk, A., Molhoek, E. M., Veldhuizen, E. J. A., Tjeerdsma - van Bokhoven, H., Wagendorp, E., Bikker, F., & Haagsman, H. P. (2009). Identification of chicken cathelicidin-2 core elements involved in antibacterial and immunomodulatory activities. Molecular Immunology, 46, 2465-2473.
Professional publications
van Dijk, A. (2009). Antimicrobiële peptiden van de kip: biologische functies en mogelijke toepassingen. Tijdschrift voor Diergeneeskunde, 134, 282-284.
2008
Scholarly publications
Veldhuizen, E. J. A., Rijnders, M., Claassen, E. A., van Dijk, A., & Haagsman, H. P. (2008). Porcine ß-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Molecular Immunology, 45, 386-394.
van Dijk, A., Veldhuizen, E. J. A., & Haagsman, H. P. (2008). Avian defensins. Veterinary Immunology and Immunopathology, 124, 1-18.
2007
Scholarly publications
Veldhuizen, E. J. A., van Dijk, A., Tersteeg, M. H., Kalkhove, S. I. C., van der Meulen, J., Niewold, T. A., & Haagsman, H. P. (2007). Expression of β-defensins pBD-1 and pBD-2 along the small intestinal tract of the pig: Lack of upregulation in vivo upon Salmonella typhimurium infection. Molecular Immunology, 44(4), 276-283. [Repository]
van Dijk, A. (2007). Chicken antimicrobial peptides: biological functions and possible applications. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Gildeprint Drukkerijen Enschede.
van Dijk, A., Veldhuizen, E. J. A., Kalkhove, S. I. C., Tjeerdsma-van Bokhoven, J. L. M., Romijn, R. A., & Haagsman, H. P. (2007). The β-defensin gallinacin-6 is expressed in the chicken digestive tract and has antimicrobial activity against food-borne pathogens. Antimicrobial Agents and Chemotherapy, 51(3), 912-922. [Repository]
2006
Scholarly publications
Hogenkamp, A., van Eijk, M., van Dijk, A., van Asten, A. J., Veldhuizen, E. J. A., & Haagsman, H. P. (2006). Characterization and expression sites of newly identified chicken collectins. Molecular Immunology, 43(10), 1604-1606.
Veldhuizen, E. J. A., Hendriks, H. G. C. J. M., Hogenkamp, A., van Dijk, A., Gaastra, W., Tooten, P. C. J., & Haagsman, H. P. (2006). Differential regulation of porcine beta-defensins 1 and 2 upon Salmonella infection in the intestinal epithelial cell line IPI-2I. Veterinary Immunology and Immunopathology, 114(1-2), 94-102. [DOI]
2005
Scholarly publications
van Dijk, A., Veldhuizen, E. J. A., van Asten, A. J. A. M., & Haagsman, H. P. (2005). CMAP27, a novel chicken cathelicidin-like antimicrobial protein. Veterinary Immunology and Immunopathology, 106, 321-327.
2002
Scholarly publications
Houben, J. H., van Dijk, A., & Eikelenboom, G. (2002). Dietary vitamin E supplementation, and ascorbic acid preparation, and packaging effects on colour stability and lipid oxidation in mince made from previously frozen lean beef. European Food Research and Technology, 214, 186-191.
2001
Scholarly publications
Houben, J. H., & van Dijk, A. (2001). Effects of dietary vitamin E supplementation and packaging on the colour stability of sliced pasteurized beef ham. Meat Science, 58, 403-407.
2000
Scholarly publications
Houben, J. H., van Dijk, A., Eikelenboom, G., & Hoving-Bolink, A. H. (2000). Effect of dietary vitamin E supplementation, fat level and packaging on colour stability and lipid oxidation in minced beef. Meat Science, 55, 331-336.
Klont, R. E., Barnier, V. H. M., van Dijk, A., Smulders, F. J. M., Hoving-Bolink, A. H., Hulsegge, B., & Eikelenboom, G. (2000). Effects of rate of pH fall, time of deboning, aging period, and their interaction on veal quality characteristics. Journal of Animal Science, 78, 1845-1851.