Alain de Bruin obtained  his DVM degree in 1994 at University of Hannover, Germany. He performed his PhD research in the field of cancer biology and graduated in 1999 at the University of Berne, Switzerland. From 1999-2002, he was a veterinary anatomic pathology resident at the Ohio State University, USA and received the board-certification by the American College of Veterinary Pathologists. His postdoctoral work was done with Gustavo Leone at the Human Cancer Genetic Institute of the Ohio State University, USA. He received a postdoctoral cancer research award by the US Department of Defense in 2003. In 2005 he was appointed as full Professor in Pathobiology at Utrecht University, Netherlands. 

He has developed a powerful combination of techniques and in vivo models to understand the pathobiology of  ageing and cancer. His research is focused on the Rb/E2F pathway, which is altered in almost all types of cancers. He discovered new members of the family E2F transcription factors and studies their impact on controlling the cell cycle, development, regeneration, ageing and cancer. He was awarded with several grants from the Dutch Cancer Foundation (KWF),  Netherlands Organization for Scientific Research (NWO) and the Worldwide Cancer Research Foundation  (AICR). In 2010, he established the Dutch Molecular Pathology Center, an expertise center for the pathological analysis of transgenic animals. In 2013 he was named as program coordinator of the research program “Regenerative Medicine, Stem cells, and Cancer” of the Faculty of Veterinary Medicine at Utrecht University. In 2014, he was awared with the Honorary Professorship for the pathological and molecular analysis of experimental animals at the University Medical Center Gronigen, Netherlands. In 2015, he estabilsed the Single Cell Analysis Center for the genomic and transcriptomic analysis of single cells at Utrecht University. In 2017 he was appointed as chairman of the Research Council of the Faculty of Veterinary Medicine for three years. Since 2020 he is the head of the Department Biomolecular Health Sciences of the Faculty of Veterinary Medicine.

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