Dr. A. (Aad) Hoek

Dr. A. (Aad) Hoek

UU
a.hoek@uu.nl

1.

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.

 

van Herwijnen MJ, Wieten L, van der Zee R, van Kooten PJ, Wagenaar-Hilbers JP, Hoek A, den Braber I, Anderton SM, Singh M, Meiring HD, van Els CA, van Eden W, Broere F.

 

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14134-9. doi: 10.1073/pnas.1206803109. Epub 2012 Aug 13.

 

PMID: 22891339 [PubMed - indexed for MEDLINE] Free PMC Article

 

Related citations

 

2.

Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis.

 

Santema W, van Kooten P, Hoek A, Leeflang M, Overdijk M, Rutten V, Koets A.

 

Vaccine. 2011 Feb 4;29(7):1364-73. doi: 10.1016/j.vaccine.2010.12.071. Epub 2011 Jan 1.

 

PMID: 21199702 [PubMed - indexed for MEDLINE]

 

Related citations

 

3.

Epitopes of Mycobacterium avium ssp. paratuberculosis 70kDa heat-shock protein activate bovine helper T cells in outbred cattle.

 

Hoek A, Rutten VP, van der Zee R, Davies CJ, Koets AP.

 

Vaccine. 2010 Aug 16;28(36):5910-9. doi: 10.1016/j.vaccine.2010.06.042. Epub 2010 Jun 25.

 

PMID: 20600507 [PubMed - indexed for MEDLINE]

 

Related citations

 

4.

Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo.

 

Hoek A, Rutten VP, Kool J, Arkesteijn GJ, Bouwstra RJ, Van Rhijn I, Koets AP.

 

Vet Res. 2009 Jan-Feb;40(1):6. doi: 10.1051/vetres:2008044. Epub 2008 Oct 18.

 

PMID: 18928784 [PubMed - indexed for MEDLINE] Free PMC Article

 

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5.

Energy metabolism of bloodstream form Trypanosoma theileri.

 

van Hellemond JJ, Hoek A, Wichgers Schreur P, Chupin V, Ozdirekcan S, Geysen D, van Grinsven KW, Koets AP, Van den Bossche P, Geerts S, Tielens AG.

 

Eukaryot Cell. 2007 Sep;6(9):1693-6. Epub 2007 Jul 20.

 

PMID: 17644652 [PubMed - indexed for MEDLINE] Free PMC Article

 

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6.

Mycobacterial 70 kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis.

 

Koets A, Hoek A, Langelaar M, Overdijk M, Santema W, Franken P, Eden Wv, Rutten V.

 

Vaccine. 2006 Mar 24;24(14):2550-9. Epub 2005 Dec 27.

 

PMID: 16417949 [PubMed - indexed for MEDLINE]

 

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7.

Comparison of three assays for the evaluation of specific cellular immunity to Leishmania infantum in dogs.

 

Fernández-Bellon H, Solano-Gallego L, Rodríguez A, Rutten VP, Hoek A, Ramis A, Alberola J, Ferrer L.

 

Vet Immunol Immunopathol. 2005 Aug 15;107(1-2):163-9.

 

PMID: 15922459 [PubMed - indexed for MEDLINE]

 

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8.

The effects of a single injection of dexamethasone-21-isonicotinate on the lymphocyte functions of dairy cows at two weeks post partum.

 

Thanasak J, Jorritsma R, Hoek A, Noordhuizen JP, Rutten VP, Müller KE.

 

Vet Res. 2004 Jan-Feb;35(1):103-12.

 

PMID: 15099507 [PubMed - indexed for MEDLINE] Free Article

 

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9.

Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gamma delta T cells, and related changes in T-cell function.

 

Koets A, Rutten V, Hoek A, van Mil F, Müller K, Bakker D, Gruys E, van Eden W.

 

Infect Immun. 2002 Jul;70(7):3856-64.

 

PMID: 12065529 [PubMed - indexed for MEDLINE] Free PMC Article

Publications

2023

Scholarly publications

Novak, A., Hindriks, E., Hoek, A., Veraart, C., Broens, E. M., Ludwig, I., Rutten, V., Sloots, A., & Broere, F. (2023). Cellular and humoral immune responsiveness to inactivated Leptospira interrogans in dogs vaccinated with a tetravalent Leptospira vaccine. Vaccine, 41(1), 119-129. https://doi.org/10.1016/j.vaccine.2022.11.017

2016

Scholarly publications

De Wolf, C., Van Der Zee, R., Den Braber, I., Glant, T., Maill??re, B., Favry, E., Van Lummel, M., Koning, F., Hoek, A., Ludwig, I., Van Eden, W., & Broere, F. (2016). An Arthritis-Suppressive and Treg Cell-Inducing CD4+ T Cell Epitope is Functional in the Context of HLA-Restricted T Cell Responses. In Arthritis and Rheumatology (pp. 639-647). (Arthritis and Rheumatology; Vol. 68, No. 3). John Wiley and Sons Inc.. https://doi.org/10.1002/art.39444
Jansen, M. A. A., Van Herwijnen, M. J. C., Van Kooten, P. J. S., Hoek, A., Van Der Zee, R., Van Eden, W., & Broere, F. (2016). Generation of the first TCR transgenic mouse with CD4+ T cells recognizing an anti-inflammatory regulatory T cell-inducing Hsp70 peptide. Frontiers in Immunology, 7, [90]. https://doi.org/10.3389/fimmu.2016.00090

2015

Scholarly publications

Spiering, R., Margry, B., Keijzer, C., Petzold, C., Hoek, A., Wagenaar-Hilbers, J., van der Zee, R., van Eden, W., Kretschmer, K., & Broere, F. (2015). DEC205+ Dendritic Cell-Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis. Journal of Immunology. https://doi.org/10.4049/jimmunol.1400986

2014

Scholarly publications

Margry, B., Kersemakers, S. C. W., Hoek, A., Arkesteijn, G. J. A., Wieland, W. H., van Eden, W., & Broere, F. (2014). Activated Peritoneal Cavity B-1a Cells Posses Regulatory B Cell Properties. PLoS One, 9(2), 1-8. [e88869]. https://doi.org/10.1371/journal.pone.0088869

2012

Scholarly publications

van Herwijnen, M. J. C., Wieten, L., van der Zee, R., van Kooten, P. J., Wagenaar, J. P. A., Hoek, A., den Braber, A. J., Anderton, S. M., Singh, M., Meiring, H. D., van Els, C. A. C. M., van Eden, W., & Broere, F. (2012). Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis. Proceedings of the National Academy of Sciences of the United States of America, 109(35), 14134-14139. https://doi.org/10.1073/pnas.1206803109

2011

Scholarly publications

Santema, W. J., van Kooten, P., Hoek, A., Leeflang, M., Overdijk, M., Koets, A. P., & Rutten, V. P. (2011). Hsp70 vaccination-induced antibodies recognize B cell epitopes in the cell wall of Mycobacterium avium subspecies paratuberculosis. Vaccine, 29, 1364-1373. https://doi.org/10.1016/j.vaccine.2010.12.071

2010

Scholarly publications

Mutsaerts, M. A. Q., Groen, H., ter Bogt, N. C., Bolster, J. H. T., Land, J. A., Bemelmans, W. J. E., Kuchenbecker, W. K. H., Hompes, P. G., Macklon, N. S., Stolk, R. P., van der Veen, F., Maas, J. W., Klijn, N. F., Kaaijk, E. M., Oosterhuis, G. J. E., Bouckaert, P. X. J. M., Schierbeek, J. M., van Kasteren, Y. M., Nap, AW., ... Hoek, A. (2010). The LIFESTYLE study: consts and effects of a structured lifestyle program in overweight and obese subfertile women to reduce the need for fertility treatment and improve reproductive outcome. A randomised controlled trial. BMC Women's Health [E], 25, 10-22. http://www.ncbi.nlm.nih.gov/pubmed/20579357
Hoek, A., Rutten, V. P. M. G., van der Zee, R., Davies, C., & Koets, A. P. (2010). Epitopes of Mycobacterium avium ssp. paratuberculosis 70 kDa heat-shock protein activate bovine helper T cells in outbred cattle. Vaccine, 28(36), 5910-5919. https://doi.org/10.1016/j.vaccine.2010.06.042

2009

Scholarly publications

Hoek, A. (2009). Heat shock protein 70 vaccination induced immune responses in bovine paratuberculosis. [Doctoral thesis 1 (Research UU / Graduation UU), Utrecht University]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/31898/hoek.pdf?sequence=1
Hoek, A., Rutten, V. P. M. G., Kool, J., Bouwstra, R. J., Arkesteijn, G. J., van Rhijn, I., & Koets, A. P. (2009). Subpopulations of bovine WC1+ gammadelta T cells rather than CD4+CD25highFoxp3+ T cells act as immune regulatory cells ex vivo. Veterinary Research, 40(1), 6.

2008

Scholarly publications

Hoek, A., Rutten, V. P. M. G., Kool, M. M. J., Arkesteijn, G., Bouwstra, R. J., van Rhijn, I., & Koets, A. P. (2008). Subpopulations of bovine WC1+ T cells rather than CD4+CD25highFoxp3+ T cells act as immune regulatory cells ex vivo. Onbekend GW. https://doi.org/10.1051/vetres:2008044

2007

Scholarly publications

van Hellemond, J. J., Hoek, A., Schreur, P. W., Chupin, V. V., Ozdirekcan, S., Geysen, D., van Grinsven, K. W. A., Koets, A. P., van den Bossche, P., Geerts, S., & Tielens, A. G. M. (2007). Energy metabolism of bloodstream form Trypanosoma theileri. Eukaryotic Cell, 6(9), 1693-1696.

2006

Scholarly publications

Koets, A. P., Hoek, A., Langelaar, M. F. M., Overdijk, M., Santema, W. I., Franken, P., van Eden, W., & Rutten, V. P. M. G. (2006). Mycobacterial 70 kD heat-shock protein is an effective subunit vaccine against bovine paratuberculosis. Vaccine, 24(14), 2550-2559.
https://dspace.library.uu.nl/bitstream/handle/1874/20233/Koets%2520Mycobacterial.pdf?sequence=1
Hoek, A., & Luchtman, M. J. J. P. (2006). The European Convention on Human Rights and transnational cooperation in criminal matters. In A. van Hoek, & et al. (Eds.), Multilevel Governance in Enforcement and Adjudication (pp. 25-92). Intersentia.

2005

Scholarly publications

Fernandez-Bellon, H., Solano-Gallego, L., Rodriguez, A., Rutten, V. P. M. G., Hoek, A., Ramis, A., Alberola, J., & Ferrer, L. (2005). Comparison of three assays for the evaluation of specific cellular immunity to Leishmania infantum in dogs. Veterinary Immunology and Immunopathology, 107, 163-169.
Thanasak, J., Muller, K. E., Dieleman, S. J., Hoek, A., Noordhuizen, J. P. T. M., & Rutten, V. P. M. G. (2005). Effects of polyunsaturated fatty acids on the proliferation of mitogen stimulated bovine peripheral blood mononuclear cells. Veterinary Immunology and Immunopathology, 104(3-4), 289-295.

2004

Scholarly publications

van den Bremer, E. T. J., Keeble, A. H., Visser, A. J. W. G., Hoek, A., Kleanthous, C., Heck, A. J. R., & Jiskoot, W. (2004). Ligand-induced changes in the conformational dynamics of a bacterial cytotoxic endonuclease. Biochemistry, 43, 4347-4355.
Thanasak, J., Rutten, V. P. M. G., Schonewille, J. T., Hoek, A., Beynen, A. C., Noordhuizen, J. P. T. M., & Müller, K. E. (2004). Effect of a dietary n-6 polyunsaturated fatty acid supplement on distinct immune functions of goats. Journal of Veterinary Medicine. Series A, Animal Physiology, Pathology and clinical veterinary medicine, 51(1), 1-9.
Thanasak, J., Jorritsma, R., Hoek, A., Noordhuizen, J. P. T. M., Rutten, V. P. M. G., & Müller, K. E. (2004). Effects of a single injection of dexamethasone-21-isoniconate on lymphocyte functions of dairy cows at two weeks postpartum. Veterinary Research, 35, 103-112.
Soethout, E. C., Antonis, A. F. G., Ulfman, L. H., Hoek, A., van der Most, R. G., Müller, K. E., & Rutten, V. P. M. G. (2004). Bovine respiratory syncytial virus infection influences the impact of alpha-4 and beta-2 integrin-mediated adhesion of peripheral blood neutrophils. Clinical and Experimental Immunology, 138, 388-395.
van den Bremer, E. T. J., Keeble, A. H., Jiskoot, W., Spelbrink, R. E. J., Maier, C. S., Hoek, A., Visser, A. J. W. G., James, R., Moore, G. R., Kleanthous, C., & Heck, A. J. R. (2004). Distinct conformational stability and functional activity of four highly homologous endonuclease colicins. Protein Science, 13, 1391-1401.

Other output

Hoek, A., Bouwstra, R., Rutten, V. P. M. G., & Koets, A. P. (2004). Epitopes of mycobacterium paratuberculosis 70 kD heat shock protein activating bovine alpha beta and gamma delta T cells. Poster session presented at 7th International Veterinary Immunology Symposium (IVIS), Quebec, Canada.
Hoek, A., Rutten, V. P. M. G., & Koets, A. P. (2004). Elimination of trypanosoma (megatrypanum) theileri (laveran 1902) from bovine cell cultures. Poster session presented at 7th International Veterinary Immunology Symposium (IVIS), Quebec, Canada.
Hoek, A., Rutten, V. P. M. G., & Koets, A. P. (2004). Elimination of trypanosoma (megatrypanum) theileri (laveran 1902) from bovine cell cultures. Poster session presented at Veterinary Science Day, Zeist.
Hoek, A., Bouwstra, R., Rutten, V. P. M. G., & Koets, A. P. (2004). Epitopes of mycobacterium paratuberculosis 70 kD heat shock protein activating bovine alpha beta and gamma delta T cells. Poster session presented at German and Dutch Societies for Immunology (JAMI), Maastricht.

2003

Other output

Hoek, A., Rutten, V. P. M. G., Bouwstra, R., Langelaar, M. F. M., & Koets, A. P. (2003). Role of Y T cells in bovine paratuberculosis. Poster session presented at Veterinary Science Day, Garderen.

2002

Scholarly publications

Blom-Veenman, J. N., Dujardin, C. L., Hoek, A., Grootendorst, A., Klein, W. R., & Rutten, V. P. M. G. (2002). High volume continuous venovenous haemofiltration (HV-CVVH) in an equine endotoxaemic shock model. Equine Veterinary Journal, 34(5), 516-522.
Koets, A. P., Rutten, V. P. M. G., Hoek, A., van Mil, F., Müller, K. E., Bakker, D., Gruys, E., & van Eden, W. (2002). Progressive bovine paratuberculosis is associated with local loss of CD4(+) T cells, increased frequency of gammadelta T cells, and related changes in T-cell function. Infection and Immunity, 70(7), 3856-3864.

2000

Scholarly publications

van Slooten, M. L., Visser, A. J. W. G., Hoek, A., Storm, G., Crommelin, D. J. A., & Jiskoot, W. (2000). Conformational stability of human interferon-gamma on association with and dissociation from liposomes. Journal of Pharmaceutical Sciences, 89, 1605-1619.

Professional publications

Hoek, A., Sinke, J. D., Willemse, A., Knol, E. F., & Rutten, V. P. M. G. (2000). Expression of IL-4 by mast cells in the skin of dogs with atopic dermatitis. Immunobiology, 203, 154.

1999

Scholarly publications

Koets, A. P., Rutten, V. P. M. G., Hoek, A., Bakker, D., Van Zijderveld, F., Müller, K. E., & Van Eden, W. (1999). Heat-shock protein-specific T-cell responses in various stages of bovine paratuberculosis. Veterinary Immunology and Immunopathology, 70(1-2), 105-115. https://doi.org/10.1016/S0165-2427(99)00062-8

1998

Scholarly publications

Bruschke, C. J. M., Haghparast, A., Hoek, A., Rutten, V. P. M. G., Wentink, G. H., Van Rijn, P. A., & Van Oirschot, J. T. (1998). The immune response of cattle, persistently infected with noncytopathic BVDV, after superinfection with antigenically semi-homologous cytopathic BVDV. Veterinary Immunology and Immunopathology, 62(1), 37-50. https://doi.org/10.1016/S0165-2427(97)00165-7

1997

Scholarly publications

Wentink, G. H., Rutten, V. P. M. G., Van Den Ingh, T. S. G. A. M., Hoek, A., Müller, K. E., & Wensing, T. (1997). Impaired specific immunoreactivity in cows with hepatic lipidosis. Veterinary Immunology and Immunopathology, 56(1-2), 77-83. https://doi.org/10.1016/S0165-2427(96)05743-1
Müller, K. E., Hoek, A., Rutten, V. P. M. G., Bernadina, W. E., & Wentink, G. H. (1997). Antigen-specific immune responses in cattle with inherited β2-integrin deficiency. Veterinary Immunology and Immunopathology, 58(1), 39-53. https://doi.org/10.1016/S0165-2427(96)05753-4
Hoek, A., & Groot, L. F. M. (1997). Baanconcurrentie op de Nederlandse markt. Tijdschrift voor Arbeidsvraagstukken, 13(2), 114-129.

1996

Scholarly publications

Rutten, V. P. M. G., Hoek, A., & Müller, K. E. (1996). Identification of monoclonal antibodies with specificity to α- or β-chains of β2-integrins using peripheral blood leucocytes of normal and Bovine Leucocyte Adhesion Deficient (BLAD) cattle. Veterinary Immunology and Immunopathology, 52(4), 341-345. https://doi.org/10.1016/0165-2427(96)05585-7
Vellema, P., Rutten, V. P. M. G., Hoek, A., Moll, L., & Wentink, G. H. (1996). The effect of cobalt supplementation on the immune response in vitamin B12 deficient Texel lambs. Veterinary Immunology and Immunopathology, 55(1-3), 151-161. https://doi.org/10.1016/S0165-2427(96)05560-2

1995

Scholarly publications

Müller, K. E., Rutten, V. P. M. G., Becker, C. K., Hoek, A., Bernadina, W. E., Henk Wentink, G., & Figdor, C. G. (1995). Allograft rejection in cattle with bovine leukocyte adhesion deficiency. Veterinary Immunology and Immunopathology, 48(1-2), 55-63. https://doi.org/10.1016/0165-2427(95)05425-6

1994

Scholarly publications

Müller, K. E., Bernadina, W. E., Kalsbeek, H. C., Hoek, A., Rutten, V. P., & Wentink, G. H. (1994). Bovine leukocyte adhesion deficiency--clinical course and laboratory findings in eight affected animals. The Veterinary quarterly, 16(2), 65-71. https://doi.org/10.1080/01652176.1994.9694420