prof. dr. A.H. (Aldert) Piersma
A.H.Piersma@uu.nl
Professor

Gegenereerd op 2018-07-20 02:37:16


Chair
Reproductie en ontwikkelingstoxicologie
Gegenereerd op 2018-07-20 02:37:16
All publications
  Articles - 2017
Dimopoulou, Myrto, Verhoef, Aart, Pennings, Jeroen L A, van Ravenzwaay, Bennard, Rietjens, Ivonne M C M & Piersma, Aldert H (01.12.2017). A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture. Toxicology, 392, (pp. 96-105) (10 p.). Copyright © 2017 Elsevier B.V. All rights reserved..
Buesen, Roland, Chorley, Brian N, da Silva Lima, Beatriz, Daston, George P., Deferme, Lize, Ebbels, Timothy, Gant, Timothy W, Goetz, Amber, Greally, John, Gribaldo, Laura, Hackermüller, Jörg, Hubesch, Bruno, Jennen, Danyel G J, Johnson, Kamin, Kanno, Jun, Kauffmann, Hans-Martin, Laffont, Madeleine, McMullen, Patrick, Meehan, Richard, Pemberton, Mark, Perdichizzi, Stefania, Piersma, Aldert H, Sauer, Ursula G, Schmidt, Kerstin, Seitz, Hervé, Sumida, Kayo, Tollefsen, Knut Erik, Tong, Weida, Tralau, Tewes, van Ravenzwaay, Ben, Weber, Ralf J M, Worth, Andrew, Yauk, Carole & Poole, Alan (2017). Applying 'omics technologies in chemicals risk assessment - Report of an ECETOC workshop. Regulatory Toxicology and Pharmacology, 91 (Suppl 1), (pp. S3-S13) (11 p.). Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved..
Theunissen, Peter T., Beken, Sonia, Beyer, Bruce K., Breslin, William J, Cappon, Gregg D, Chen, Connie L, Chmielewski, Gary, de Schaepdrijver, Luc, Enright, Brian, Foreman, Jennifer E, Harrouk, Wafa, Hew, Kok-Wah, Hoberman, Alan M, Y Hui, Julia, Knudsen, Thomas B, Laffan, Susan B, Makris, Susan L, Martin, Matthew, McNerney, Mary Ellen, Siezen, Christine L E, Stanislaus, Dinesh J, Stewart, Jane, Thompson, Kary E, Tornesi, Belen, Van Der Laan, Jan Willem, Weinbauer, Gerhard F, Wood, Sandra & Piersma, Aldert H (2017). Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals - on systemic dose and developmental effects. Critical Reviews in Toxicology, 47 (5), (pp. 402-414) (13 p.).
Dimopoulou, Myrto, Verhoef, Aart, Pennings, Jeroen L A, van Ravenzwaay, Bennard, Rietjens, Ivonne M C M & Piersma, Aldert H (01.05.2017). Embryotoxic and pharmacologic potency ranking of six azoles in the rat whole embryo culture by morphological and transcriptomic analysis. Toxicology and Applied Pharmacology, 322, (pp. 15-26) (12 p.). Copyright © 2017 Elsevier Inc. All rights reserved..
Fragki, Styliani, Piersma, Aldert H, Rorije, Emiel & Zeilmaker, Marco J (01.10.2017). In vitro to in vivo extrapolation of effective dosimetry in developmental toxicity testing - Application of a generic PBK modelling approach. Toxicology and Applied Pharmacology, 332, (pp. 109-120) (12 p.). Copyright © 2017 Elsevier Inc. All rights reserved..
Aschner, Michael, Ceccatelli, Sandra, Daneshian, Mardas, Fritsche, Ellen, Hasiwa, Nina, Hartung, Thomas, Hogberg, Helena T, Leist, Marcel, Li, Abby, Mundi, William R, Padilla, Stephanie, Piersma, Aldert H, Bal-Price, Anna, Seiler, Andrea, Westerink, Remco H, Zimmer, Bastian & Lein, Pamela J (2017). Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. ALTEX-Alternatives to Animal Experimentation, 34 (1), (pp. 49-74) (26 p.).
Solecki, Roland, Kortenkamp, Andreas, Bergman, Åke, Chahoud, Ibrahim, Degen, Gisela H, Dietrich, Daniel, Greim, Helmut, Håkansson, Helen, Hass, Ulla, Husoy, Trine, Jacobs, Miriam, Jobling, Susan, Mantovani, Alberto, Marx-Stoelting, Philip, Piersma, Aldert, Ritz, Vera, Slama, Remy, Stahlmann, Ralf, van den Berg, Martin, Zoeller, R Thomas & Boobis, Alan R (2017). Scientific principles for the identification of endocrine-disrupting chemicals - a consensus statement. Archiv fur Toxikologie, 91 (2), (pp. 1001-1006).
  Articles - 2016
Lenters, Virissa, Portengen, Lützen, Rignell-Hydbom, Anna, Jönsson, Bo A, Lindh, Christian H, Piersma, Aldert H, Toft, Gunnar, Bonde, Jens P, Heederik, Dick, Rylander, Lars & Vermeulen, Roel (2016). Prenatal Phthalate, Perfluoroalkyl Acid, and Organochlorine Exposures and Term Birth Weight in Three Birth Cohorts - Multi-Pollutant Models Based on Elastic Net Regression. Environmental Health Perspectives, 124 (3), (pp. 365-372) (12 p.).
  Articles - 2015
Hougaard, Karin Sørig, Campagnolo, Luisa, Chavatte-Palmer, Pascale, Tarrade, Anne, Rousseau-Ralliard, Delphine, Valentino, Sarah, Park, Margriet V D Z, de Jong, Wim H, Wolterink, Gerrit, Piersma, Aldert H, Ross, Bryony L, Hutchison, Gary R, Hansen, Jitka Stilund, Vogel, Ulla, Jackson, Petra, Slama, Rémy, Pietroiusti, Antonio & Cassee, Flemming R (15.08.2015). A perspective on the developmental toxicity of inhaled nanoparticles. Reproductigve Toxicoloy, 56, (pp. 118-40) (23 p.). Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved..
Schulpen, Sjors H. W., Theunissen, Peter T., Pennings, Jeroen L. A. & Piersma, Aldert H. (15.08.2015). Comparison of gene expression regulation in mouse- and human embryonic stem cell assays during neural differentiation and in response to valproic acid exposure. Reproductive Toxicology, 56, (pp. 77-86) (10 p.).
Tonk, Elisa C. M., Verhoef, Aart, Gremmer, Eric R., van Loveren, Henk & Piersma, Aldert H. (2015). Developmental immunotoxicity testing of 4-methyl anisole. Regulatory Toxicology and Pharmacology, 72 (2), (pp. 379-385) (7 p.).
Schulpen, Sjors H. W., de Jong, Esther, de la Fonteyne, Liset J. J., de Klerk, Arja & Piersma, Aldert H. (2015). Distinct gene expression responses of two anticonvulsant drugs in a novel human embryonic stem cell based neural differentiation assay protocol. Toxicology in Vitro, 29 (3), (pp. 449-457) (9 p.).
Kroese, E. Dinant, Bosgra, Sieto, Buist, Harrie E., Lewin, Geertje, van der Linden, Sander C., Man, Hai-yen, Piersma, Aldert H., Rorije, Emiel, Schulpen, Sjors H. W., Schwarz, Michael, Uibel, Frederik, van Vugt-Lussenburg, Barbara M. A., Wolterbeek, Andre P. M. & van der Burg, Bart (01.08.2015). Evaluation of an alternative in vitro test battery for detecting reproductive toxicants in a grouping context. Reproductive Toxicology, 55, (pp. 11-19) (9 p.).
Schulpen, Sjors H. W., Pennings, Jeroen L. A. & Piersma, Aldert H. (2015). Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicological Sciences, 146 (2), (pp. 311-320) (10 p.).
Lenters, Virissa, Portengen, Lützen, Smit, Lidwien A M, Jönsson, Bo A G, Giwercman, Aleksander, Rylander, Lars, Lindh, Christian H, Spanò, Marcello, Pedersen, Henning S, Ludwicki, Jan K, Chumak, Lyubov, Piersma, Aldert H, Toft, Gunnar, Bonde, Jens Peter, Heederik, Dick & Vermeulen, Roel (01.06.2015). Phthalates, perfluoroalkyl acids, metals and organochlorines and reproductive function: a multipollutant assessment in Greenlandic, Polish and Ukrainian men. Occupational and Environmental Medicine, 72 (6), (pp. 385-393) (9 p.).
Smit, Lidwien A M, Lenters, Virissa, Høyer, Birgit Bjerre, Lindh, Christian H, Pedersen, Henning S, Liermontova, Iuliia, Jönsson, Bo A G, Piersma, Aldert H, Bonde, Jens Peter, Toft, Gunnar, Vermeulen, Roel & Heederik, Dick (2015). Prenatal exposure to environmental chemical contaminants and asthma and eczema in school-age children. Allergy: European Journal of Allergy and Clinical Immunology, 70 (6), (pp. 653-660) (8 p.). This article is protected by copyright. All rights reserved..
Roelofs, Maarke J, van den Berg, Martin, Bovee, Toine F H, Piersma, Aldert H & van Duursen, Majorie B (08.01.2015). Structural bisphenol analogues differentially target steroidogenesis in murine MA-10 Leydig cells as well as the glucocorticoid receptor. Toxicology, 329C, (pp. 10-20) (11 p.). Copyright © 2015 Elsevier Ireland Ltd. All rights reserved..
  Articles - 2014
Schulpen, Sjors H W, Pennings, Jeroen L A, Tonk, Elisa C M & Piersma, Aldert H. (21.03.2014). A statistical approach towards the derivation of predictive gene sets for potency ranking of chemicals in the mouse embryonic stem cell test. Toxicology Letters, 225 (3), (pp. 342-349) (8 p.).
de Jong, Esther, van Beek, Lianne & Piersma, Aldert H. (01.01.2014). Comparison of osteoblast and cardiomyocyte differentiation in the embryonic stem cell test for predicting embryotoxicity in vivo. Reproductigve Toxicoloy, 48, (pp. 62-71) (10 p.).
Roelofs, Maarke J.E., Temming, A. Roberto, Piersma, Aldert H., van den Berg, Martin & van Duursen, Majorie B.M. (2014). Conazole fungicides inhibit Leydig cell testosterone secretion and androgen receptor activation in vitro. Toxicology Reports, 1, (pp. 271-283) (13 p.).
van Dartel, Dorien A M, Schulpen, Sjors H., Theunissen, Peter T., Bunschoten, Annelies, Piersma, Aldert H. & Keijer, Jaap (03.10.2014). Dynamic changes in energy metabolism upon embryonic stem cell differentiation support developmental toxicant identification. Toxicology, 324, (pp. 76-87) (12 p.).
Daston, George P., Beyer, Bruce K., Carney, Edward W., Chapin, Robert E., Friedman, Jan M., Piersma, Aldert H., Rogers, John M. & Scialli, Anthony R. (01.01.2014). Exposure-based validation list for developmental toxicity screening assays. Birth Defects Research Part B - Developmental and Reproductive Toxicology, 101 (6), (pp. 423-428) (6 p.).
Theunissen, P. T., Beken, S., Cappon, G. D., Chen, C., Hoberman, A. M., van der Laan, J. W., Stewart, J. & Piersma, A. H. (01.08.2014). Toward a comparative retrospective analysis of rat and rabbit developmental toxicity studies for pharmaceutical compounds. Reproductive Toxicology, 47, (pp. 27-32) (6 p.).
Beker van Woudenberg, Anna, Snel, Cor, Rijkmans, Eke, De Groot, Didima, Bouma, Marga, Hermsen, Sanne, Piersma, Aldert, Menke, Aswin & Wolterbeek, André (01.01.2014). Zebrafish embryotoxicity test for developmental (neuro)toxicity - Demo case of an integrated screening approach system using anti-epileptic drugs. Reproductigve Toxicoloy, 49, (pp. 101-116) (16 p.).
  Articles - 2013
Chapin, R.E., Boekelheide, K., Cortvrindt, R., van Duursen, M.B.M., Gant, T., Jegou, B., Marczylo, E., van Pelt, A.M.M., Post, J.N., Roelofs, M.J.E., Schlatt, S., Teerds, K.J., Toppari, J. & Piersma, A.H. (2013). Assuring safety without animal testing: the case for the human testis in vitro. Reproductive Toxicology, 39, (pp. 63-68) (6 p.).
Theunissen, P.T., Pennings, J.L.A., van Dartel, D.A.M., Robinson, J.F., Kleinjans, J.C.S. & Piersma, A.H. (2013). Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests. Toxicological Sciences, 132 (1), (pp. 118-130) (13 p.).
Tonk, E.C.M., Verhoef, A., Gremmer, E.R., van Loveren, H. & Piersma, A.H. (2013). Developmental immunotoxicity in male rats after juvenile exposure to ethanol. Toxicology, 309, (pp. 91-99) (9 p.).
Tonk, E.C.M., de Groot, D.M.G., Wolterbeek, A., Penninks, A.H., Waalkens-Berendsen, I.D.H., Piersma, A.H. & van Loveren, H. (2013). Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study. Archiv fur Toxikologie, 87 (2), (pp. 323-335) (13 p.).
Schulpen, S., Robinson, J., Pennings, J., van Dartel, D.A.M. & Piersma, A.H. (2013). Dose response analysis of monophthalates in the murine embryonic stem cell test assessed by cardiomyocyte differentiation and gene expression. Reproductigve Toxicoloy, 35, (pp. 81-88) (8 p.).
Dankers, Anita C A, Roelofs, Maarke J E, Piersma, Aldert H, Sweep, Fred C G J, Russel, Frans G M, van den Berg, Martin, van Duursen, Majorie B M & Masereeuw, R. (2013). Endocrine disruptors differentially target ATP-binding cassette transporters in the blood-testis barrier and affect Leydig cell testosterone secretion in vitro. Toxicological Sciences, 136 (2), (pp. 382-391) (10 p.).
Piersma, A.H., Bosgra, S., van Duursen, M.B.M., Hermsen, S.A.B., Jonker, L.R., Kroese, E.D., Linden, S.C., Man, H., Roelofs, M.J.E., Schulpen, S.H., Schwarz, M., Uibel, F., van Vugt-Lussenburg, B.M., Westerhout, J., Wolterbeek, A.P.M. & van der Burg, B. (2013). Evaluation of an alternative in vitro test battery for detecting reproductive toxicants. Reproductigve Toxicoloy, 38, (pp. 53-64) (12 p.).
Parks Saldutti, L., Beyer, B.K., Breslin, W., Brown, T.R., Chapin, R.E., Campion, S., Enright, B., Faustman, E., Foster, P.M., Hartung, T., Kelce, W., Kim, J.H., Loboa, E.G., Piersma, A.H., Seyler, D., Turner, K.J., Yu, H., Yu, X. & Sasaki, J.C. (2013). In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques. ALTEX-Alternatives to Animal Experimentation, 30 (3), (pp. 353-377) (25 p.).
Hettne, K.M., Boorsma, A., van Dartel, D.A.M., Goeman, J.J., de Jong, E., Piersma, A.H., Stierum, R.H., Kleinjans, J.C. & Kors, J.A. (2013). Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data. BMC Medical Genomics, 6, (pp. 2) (1 p.).
Lenters, V.C., Thomsen, C., Smit, L.A., Jönsson, B.A.G., Pedersen, H.S., Ludwicki, J.K., Zviezdai, V., Piersma, A.H., Toft, G., Bonde, J.P., Becher, G., Vermeulen, R. & Heederik, D. (2013). Serum concentrations of polybrominated diphenyl ethers (PBDEs) and a polybrominated biphenyl (PBB) in men from Greenland, Poland and Ukraine. Environmental International, 61, (pp. 8-16) (9 p.).
Roelofs, M.J.E., Piersma, A.H., van den Berg, M. & van Duursen, M.B.M. (2013). The relevance of chemical interactions with CYP17 enzyme activity: assessment using a novel in vitro assay. Toxicology and Applied Pharmacology, 268 (3), (pp. 309-317) (9 p.).
Hermsen, S.A.B., Pronk, T., van den Brandhof, E.J., van der Ven, L.T.M. & Piersma, A.H. (2013). Transcriptomic analysis in the developing zebrafish embryo after compound exposure: Individual gene expression and pathway regulation. Toxicology and Applied Pharmacology, 272 (1), (pp. 161-171) (11 p.).
Tonk, E.C.M., Robinson, J.F., Verhoef, A., Theunissen, P.T., Pennings, J.L.A. & Piersma, A.H. (2013). Valproic acid-induced gene expression responses in rat whole embryo culture and comparison across in vitro developmental and non-developmental models. Reproductive Toxicology, 41, (pp. 57-66) (10 p.).
  Articles - 2012
Robinson, J.F., Verhoef, A., Pennings, J.L.A., Pronk, T. & Piersma, A.H. (2012). A comparison of gene expression responses in rat whole embryo culture and in vivo: time-dependent retinoic acid-induced teratogenic response. Toxicological Sciences, 126 (1), (pp. 242-254) (13 p.).
Pennings, J.L.A., Theunissen, P.T. & Piersma, A.H. (2012). An optimized gene set for transcriptomics based neurodevelopmental toxicity prediction in the neural embryonic stem cell test. Toxicology, 300 (3), (pp. 158-167) (9 p.).
Theunissen, P.T., Robinson, J.F., Pennings, J.L.A., van Herwijnen, M., Kleinjans, J.C.S. & Piersma, A.H. (2012). Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn). Toxicology and Applied Pharmacology, 262 (3), (pp. 330-340) (11 p.).
Hermsen, S.A.B., Pronk, T., van den Brandhof, E.J., van der Ven, L.T.M. & Piersma, A.H. (2012). Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure. Toxicological Sciences, 127 (1), (pp. 303-312) (10 p.).
Robinson, J.F., Verhoef, A., van Beelen, V.A., Pennings, J.L.A. & Piersma, A.H. (2012). Dose-response analysis of phthalate effects on gene expression in rat whole embryo culture. Toxicology and Applied Pharmacology, 264 (1), (pp. 32-41) (10 p.).
Theunissen, P.T. & Piersma, A.H. (2012). Innovative approaches in the embryonic stem cell test (EST). Frontiers in Bioscience - Elite, 17, (pp. 1965-1975) (11 p.).
Piersma, A.H., Tonk, E.C.M., Makris, S.L., Crofton, K.M., Dietert, R.R. & van Loveren, H. (2012). Juvenile toxicity testing protocols for chemicals. Reproductive Toxicology, 34 (3), (pp. 482-486) (5 p.).
de Jong, E., van Beek, L. & Piersma, A.H. (2012). Osteoblast differentiation of murine embryonic stem cells as a model to study the embryotoxic effect of compounds. Toxicology in Vitro, 26 (6), (pp. 970-978) (9 p.).
Rorije, E., van Hienen, F.J.W., Dang, Z.C., Hakkert, B.H., Vermeire, T. & Piersma, A.H. (2012). Relative parameter sensitivity in prenatal toxicity studies with substances classified as developmental toxicants. Reproductigve Toxicoloy, 34 (2), (pp. 284-290) (7 p.).
Tonk, E.C.M., Verhoef, A., Gremmer, E.R., van Loveren, H. & Piersma, A.H. (2012). Relative sensitivity of developmental and immune parameters in juvenile versus adult male rats after exposure to di(2-ethylhexyl) phthalate. Toxicology and Applied Pharmacology, 260 (1), (pp. 48-57) (10 p.).
Madden, J.C., Hewitt, M., Przybylak, K., Vandebriel, R.J., Piersma, A.H. & Cronin, M.T. (2012). Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy. Regulatory Toxicology and Pharmacology, 63 (1), (pp. 140-154) (15 p.).
Robinson, J.F., Verhoef, A. & Piersma, A.H. (2012). Transcriptomic analysis of neurulation and early organogenesis in rat embryos: an in vivo and ex vivo comparison. Toxicological Sciences, 126 (1), (pp. 255-266) (9 p.).
Theunissen, P., Robinson, J.F., Pennings, J.L.A., de Jong, E., Claessen, S.M.H., Kleinjans, J.C.S. & Piersma, A.H. (2012). Transcriptomic concentration-response evaluation of valproic acid, cyproconazole, and hexaconazole in the neural embryonic stem cell test (ESTn). Toxicological Sciences, 125 (2), (pp. 430-438) (9 p.).
Robinson, J.F., Tonk, E.C.M., Verhoef, A. & Piersma, A.H. (2012). Triazole induced concentration-related gene signatures in rat whole embryo culture. Reproductive Toxicology, 34, (pp. 275-283) (9 p.).
Hermsen, S.A.B., Pronk, T., van den Brandhof, E.J., van der Ven, L.T. & Piersma, A.H. (2012). Triazole-induced gene expression changes in the zebrafish embryo. Reproductigve Toxicoloy, 34 (2), (pp. 216-224) (9 p.).
  Articles - 2011
Hermsen, S.A.B., Pronk, T., van den Brandhof, E.J., van der Ven, L.T.M. & Piersma, A.H. (2011). Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals. Reproductigve Toxicoloy, 32 (2), (pp. 245-252) (7 p.).
Piersma, A.H., Rorije, E., Beekhuijzen, MEW, Cooper, R., Dix, D.J., Heinrich-Hirsch, B., Martin, M., Mendez, E., Muller, A., Paparella, M., Ramsingh, D., Reaves, E., Ridgway, P., Schenk, E., Stachiw, L., Ulbrich, B. & Hakkert, B.C. (2011). Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring. Reproductigve Toxicoloy, 31 (4), (pp. 392-401) (10 p.).
Robinson, J.F., Theunissen, P.T., van Dartel, D.A.M., Pennings, J.L.A., Faustman, E.M. & Piersma, A.H. (2011). Comparison of MeHg-induced toxicogenomic responses across in vivo and in vitro models used in developmental toxicology. Reproductive Toxicology, 32 (2), (pp. 180-188) (9 p.).
de Jong, E., Barenys, M., Hermsen, S.A.B., Verhoef, A., Ossendorp, B.C., Bessems, J.G.M. & Piersma, A.H. (2011). Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles. Toxicology and Applied Pharmacology, 253 (2), (pp. 103-111) (9 p.).
van Dartel, D.A.M., Pennings, J.L.A., de la Fonteyne-Blankestijn, L.J.J., Brauers, K.J., Claessen, S., van Delft, J.H., Kleinjans, J.C.S. & Piersma, A.H. (2011). Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures. Toxicology and Applied Pharmacology, 251 (2), (pp. 110-118) (9 p.).
Tonk, E.C.M., Verhoef, A., de la Fonteyne, L.J.J., Waalkens-Berendsen, I.D.H., Wolterbeek, A.P.M., van Loveren, H. & Piersma, A.H. (2011). Developmental immunotoxicity in male rats after juvenile exposure to di-n-octyltin dichloride (DOTC). Reproductigve Toxicoloy, 32 (3), (pp. 341-348) (8 p.).
Tonk, E.C.M., de Groot, D.M.G., Penninks, A.H., Waalkens-Berendsen, I.D.H., Wolterbeek, A.P.M. & Piersma, A.H. (2011). Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study. Toxicology Letters, 204 (2-3), (pp. 156-163) (8 p.).
van Dartel, D.A.M., Pennings, J.L.A., Robinson, J.F., Kleinjans, J.C.S. & Piersma, A.H. (2011). Discriminating classes of developmental toxicants using gene expression profiling in the embryonic stem cell test. Toxicology Letters, 201 (2), (pp. 143-151) (9 p.).
van Dartel, D.A.M., Pennings, J.L.A., Brauers, K.J., Claessen, S., van Delft, J.H., Kleinjans, J.C.S. & Piersma, A.H. (2011). Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures. Toxicological Sciences, 119 (1), (pp. 126-134) (9 p.).
Pennings, J.L.A., van Dartel, D.A.M., Robinson, J.F., Pronk, T. & Piersma, A.H. (2011). Gene set assembly for quantitative prediction of developmental toxicity in the embryonic stem cell test. Toxicology, 284 (1-3), (pp. 63-71) (9 p.).
Rorije, E., Muller, A., Beekhuijzen, MEW, Hass, U., Heinrich-Hirsch, B., Paparella, M., Schenk, E., Ulbrich, B., Hakkert, B.C. & Piersma, A.H. (2011). On the impact of second generation mating and offspring in multi-generation reproductive toxicity studies on classification and labelling of substances in Europe. Regulatory Toxicology and Pharmacology, 61 (2), (pp. 251-260) (10 p.).
de Jong, E., Doedée, A.M., Reis-Fernandes, M.A., Nau, H. & Piersma, A.H. (2011). Potency ranking of valproic acid analogues as to inhibition of cardiac differentiation of embryonic stem cells in comparison to their in vivo embryotoxicity. Reproductigve Toxicoloy, 31 (4), (pp. 375-382) (8 p.).
Hermsen, S.A.B., van den Brandhof, E.J., van der Ven, L.T.M. & Piersma, A.H. (2011). Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies. Toxicology in Vitro, 25 (3), (pp. 745-753) (9 p.).
Piersma, A.H., Hernandez, L.G., van Benthem, J., Muller, J.J.A., Leeuwen, F.X.R., Vermeire, T.G. & Raaij, M.T. (2011). Reproductive toxicants have a threshold of adversity. Critical Reviews in Toxicology, 41 (6), (pp. 545-554) (10 p.).
van Dartel, D.A.M. & Piersma, A.H. (2011). The embryonic stem cell test combined with toxicogenomics as an alternative testing model for the assessment of developmental toxicity. Reproductive Toxicology, 32 (2), (pp. 235-244) (10 p.).
Theunissen, P.T., Pennings, J.L.A., Robinson, J.F., Claessen, S.M.H., Kleinjans, J.C.S. & Piersma, A.H. (2011). Time-response evaluation by transcriptomics of methylmercury effects on neural differentiation of murine embryonic stem cells. Toxicological Sciences, 122 (2), (pp. 437-447) (11 p.).
van der Burg, B., Kroese, E.D. & Piersma, A.H. (2011). Towards a pragmatic alternative testing strategy for the detection of reproductive toxicants. Reproductive Toxicology, 31 (4), (pp. 558-561) (4 p.).
  Articles - 2010
Theunissen, P.T., Schulpen, S., van Dartel, D.A.M., Hermsen, S.A.B., van Schooten, F.J. & Piersma, A.H. (2010). An abbreviated protocol for multilineage neural differentiation of murine embryonic stem cells and its perturbation by methyl mercury. Reproductigve Toxicoloy, 29 (4), (pp. 383-392) (10 p.).
Tonk, E.C.M., de Groot, D.M.G., Penninks, A.H., Waalkens-Berendsen, I.D.H., Wolterbeek, A.P.M., Slob, W., Piersma, A.H. & van Loveren, H. (2010). Developmental immunotoxicity of methylmercury: the relative sensitivity of developmental and immune parameters. Toxicological Sciences, 117 (2), (pp. 325-335) (11 p.).
Robinson, J.F., van Beelen, V.A., Verhoef, A., Renkens, M.F.J., Luijten, M., van Herwijnen, M., Westerman, A., Pennings, J.L. & Piersma, A.H. (2010). Embryotoxicant-specific transcriptomic responses in rat postimplantation whole-embryo culture. Toxicological Sciences, 118 (2), (pp. 675-685) (11 p.).
van Dartel, D.A.M., Pennings, J.L., de la Fonteyne, L.J.J., Herwijnen, M.H., Delft, J.H., van Schooten, F.J. & Piersma, A.H. (2010). Monitoring developmental toxicity in the embryonic stem cell test using differential gene expression of differentiation-related genes. Toxicological Sciences, 116 (1), (pp. 130-139) (10 p.).
Osman, A.M., van Dartel, D.A.M., Zwart, E., Blokland, M., Pennings, J.L. & Piersma, A.H. (2010). Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity. Reproductigve Toxicoloy, 30 (2), (pp. 322-332) (11 p.).
Piersma, A.H. (2010). Reproductive Toxicology. Editorial. Reproductive Toxicology, 30 (1), (pp. 1-1) (1 p.).
Louisse, J., de Jong, E., van de Sandt, J.J.M., Blaauboer, B.J., Woutersen, R.A., Piersma, A.H., Rietjens, I.M.C.M. & Verwei, M. (2010). The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man. Toxicological Sciences, 118 (2), (pp. 470-484) (15 p.).
van Dartel, D.A.M., Pennings, J.L., van Schooten, F.J. & Piersma, A.H. (2010). Transcriptomics-based identification of developmental toxicants through their interference with cardiomyocyte differentiation of embryonic stem cells. Toxicology and Applied Pharmacology, 243 (3), (pp. 420-428) (9 p.).
  Articles - 2009
van Dartel, D.A., Zeijen, N.J., de la Fonteyne-Blankestijn, L.J.J., van Schooten, F.J. & Piersma, A.H. (2009). Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol. Reproductigve Toxicoloy, 28 (2), (pp. 254-261) (12 p.).
van Dartel, D.A., Pennings, J., Hendriksen, P.J., van Schooten, F.J. & Piersma, A.H. (2009). Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate. Reproductigve Toxicoloy, 27 (2), (pp. 93-102) (10 p.).
van der Ven, L.T., van de Kuil, T., Leonards, P.E., Slob, W., Lilienthal, H., Litens, S., Herlin, M., Hakansson, H., Canton, R.F., van den Berg, M., Visser, T.J., van Loveren, H., Vos, J.G. & Piersma, A.H. (2009). Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats. Toxicology Letters, 185 (1), (pp. 51-62) (12 p.).
Park, M.V., Annema, W., Salvati, A., Lesniak, A., Elsaesser, A., Barnes, C., McKerr, G., Howard, C., Lynch, I., Dawson, K., Piersma, A.H. & de Jong, W.H. (2009). In vitro developmental toxicity test detects inhibition of stem cell differentiation by silica nanoparticles. Toxicology and Applied Pharmacology, 240 (1), (pp. 108-116) (9 p.).
Lilienthal, H., Slob, W., van der Ven, L.T. & Piersma, A.H. (2009). Measurement and evaluation of neurobehavioral effects induced by tetrabromobisphenol A (TBBPA) - Response to Strain et al. (2009). Toxicology, 260 (1-3), (pp. 158-161) (3 p.).
de Jong, E., Louisse, J., Verwei, M., Blaauboer, B.J., van de Sandt, J.J.M., Woutersen, R.A., Rietjens, I.M.C.M. & Piersma, A.H. (2009). Relative developmental toxicity of glycol ether alkoxy acid metabolites in the embryonic stem cell test as compared with the in vivo potency of their parent compounds. Toxicological Sciences, 110 (1), (pp. 117-124) (8 p.).
van der Ven, L.T., Slob, W., Piersma, A.H. & Opperhuizen, A. (2009). The benchmark approach is the preferred method to describe the toxicology of tetrabromobisphenol A (TBBPA) - Response to Banasik et al. (2009). Toxicology, 260 (1-3), (pp. 153-154) (2 p.).
  Articles - 2008
van der Ven, L.T., van de Kuil, T., Verhoef, A., Leonards, P.E., Slob, W., Canton, R., Germer, S., Hamers, T., Visser, T.J., Litens, S., Hakansson, H., Fery, Y., Schrenk, D., van den Berg, M., Piersma, A.H. & Vos, J.G. (2008). A 28-day oral dose toxicity study enhanced to detect endocrine effects of a purified technical pentabromodiphenyl ether (pentaBDE) mixture in Wistar rats. Toxicology, 245 (1-2), (pp. 109-122) (24 p.).
van der Ven, L.T., van de Kuil, T., Leonards, P.E., Slob, W., Canton, R., Germer, S., Visser, T.J., Litens, S., Hakansson, H., Schrenk, D., van den Berg, M., Piersma, A.H., Vos, J.G. & Opperhuizen, A. (2008). A 28-day oral dose toxicity study in Wistar rats enhanced to detect endocrine effects of decabromodiphenyl ether (decaBDE). Toxicology Letters, 179, (pp. 6-14) (3 p.).
Janer, G., Hakkert, B.C., Slob, W., Vermeire, T. & Piersma, A.H. (2008). A retrospective analysis of the two-generation study, author response to letter to the editor. Reproductigve Toxicoloy, 25 (4), (pp. 406-407) (2 p.).
van Meeuwen, J.A., van Son, O., Piersma, A.H., de Jong, P.C. & van den Berg, M. (2008). Aromatase inhibiting and combined estrogenic effects of parabens and estrogenic effects of other additives in cosmetics. Toxicology and Applied Pharmacology, 230 (3), (pp. 372-382) (10 p.).
van Meeuwen, J.A., Nijmeijer, S., Mutarapat, T., Ruchirawat, S., de Jong, P.C., Piersma, A.H. & van den Berg, M. (2008). Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts - a comparative study. Toxicology and Applied Pharmacology, 228 (3), (pp. 269-276) (8 p.).
van der Ven, L.T., van de Kuil, T., Verhoef, A., Verwer, C.M., Lilienthal, H., Leonards, P.E., Schauer, U.M., Canton, R., Litens, S., de Jong, F.H., Visser, T.J., Dekant, W., Stern, N., Hakansson, H., Slob, W., van den Berg, M., Vos, J.G. & Piersma, A.H. (2008). Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study. Toxicology, 245 (1-2), (pp. 76-89) (14 p.).
van der Ven, L.T., Slob, W., Piersma, A.H., Leonards, P.E., Hamers, T., Sandholm, A., van den Berg, M. & Opperhuizen, A. (2008). More on the toxicity of decabromodiphenyl ether - Response to Hardy et al. Toxicology Letters, 182 (1-3), (pp. 130-132) (3 p.).
Fernández Cantón, R., Peijnenburg, A.A., Hoogenboom, R.L., Piersma, A.H., van der Ven, L.T.M., van den Berg, M. & Heneweer, M. (2008). Subacute effects of hexabromocyclododecane (HBCD) on hepatic gene expression profiles in rats. Toxicology and Applied Pharmacology, 231 (2), (pp. 267-272) (5 p.).
  Articles - 2007
van Meeuwen, J A, Korthagen, N, de Jong, P C, Piersma, A H & van den Berg, M (15.06.2007). (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. Toxicology and Applied Pharmacology, 221 (3), (pp. 372-383) (12 p.).
van Meeuwen, J.A., van den Berg, M., Sanderson, J.T., Verhoef, A. & Piersma, A.H. (2007). Estrogenic effects of mixtures of phyto- and synthetic chemicals on uterine growth of prepubertal rats. Toxicology Letters, 170 (2), (pp. 165-176) (12 p.).
van Meeuwen, J.A., Ter burg, W., Piersma, A.H., van den Berg, M. & Sanderson, J.T. (2007). Mixture effects of estrogenic compounds on proliferation and pS2 expression of MCF-7 human breast cancer cells. Food and Chemical Toxicology, 45 (11), (pp. 2319-2330) (12 p.).
  Articles - 2005
Slob, W., Moerbeek, M., Rauniomaa, E. & Piersma, A.H. (2005). A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints. Toxicological Sciences, 84, (pp. 167-185) (19 p.).
  Articles - 2004
Moerbeek, M., Piersma, A.H. & Slob, W. (2004). A comparison of three methods for calculating confidence intervals for the benchmark dose. Risk Analysis, 24, (pp. 31-40) (10 p.).
  Articles - 2003
Kroes, R., Renwick, A.G., Cheeseman, M., Kleiner, J., Mangelsdorf, I., Piersma, A.H., Schilter, B., Schlatter, J., van Schothorst, F., Vos, J.G. & Wurtzen, G. (2003). Structure-based thresholds of toxicological concern (TTC): guidance for application to substances present at low levels in the diet. Food and Chemical Toxicology, 42, (pp. 65-83) (19 p.).
  Articles - 2000
Piersma, A.H., Verhoef, A., te Beisebeek, J.D., Pieters, M.N. & Slob, W. (2000). Developmental toxicity of butyl benzyl phalate in the rat using a multiple dose study design. Reproductigve Toxicoloy, 14, (pp. 417-425) (9 p.).
  Book parts / chapters - 2013
Piersma, A.H. (2013). Innovations in Testing Strategies in Reproductive Toxicology. Chapter 25. In P.C. Barrow (Eds.), Teratogenicity Testing, Methods and Protocols (pp. 327-341) (14 p.).
van Schulpen, S.H.W. & Piersma, A.H. (2013). The Embryonic Stem Cell Test. Chapter 27. In P.C. Barrow (Eds.), Teratogenicity Testing, Methods and Protocols (pp. 375-382) (8 p.).
Robinson, J.F. & Piersma, A.H. (2013). Toxicogenomic Approaches in Developmental Toxicology Testing. Chapter 31. In P.C. Barrow (Eds.), Teratogenicity Testing, Methods and Protocols (pp. 451-473) (22 p.).
  Book parts / chapters - 2012
Robinson, J.F., Pennings, J.L. & Piersma, A.H. (2012). Chapter 22: A Review of Toxicogenomic Approaches in Developmental Toxicology. In C. Harris & J.M. Hansen (Eds.), Developmental Toxicology: Methods and Protocols, Methods in Molecular Biology (pp. 347-371) (483 p.). Humana Press.
  Lectures - 2015
A.H. Piersma (16.10.2015) Alternatives in reproductive toxicity testing. Van Genderen Symposium, 16 October 2015, Utrecht, The Netherlands.
A.H. Piersma (23.09.2015) An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis. Barcelona AgChem Forum, 23-24 September 2015, invited lecture.
A.H. Piersma (12.05.2015) EOGRTS: background, issues and considerations. Lecture, IRDG meeting, East Midlands, UK, 12 May 2015
A.H. Piersma (12.03.2015) Innovative testing in reproductive and developmental toxicology. Lecture, Symposium of the Dutch Society of Toxicology (NVT), Section Occupational Toxicology and the Contact Group Chemistry (CGC), Den Bosch, 12 March 2015.
A.H. Piersma (12.10.2015) Low dose in endocrine disruption. Endocrine Disrupters Conference, ChemAcademy, Berlin, 12-14 October 2015, invited lecture.
A.H. Piersma (13.08.2015) Molecular biomarkers in mechanistic studies for detecting developmental toxicity. Prague EEMGS meeting 23-26 August 2015, invited lecture.
A.H. Piersma (16.06.2015) Next Steps for Adverse Outcome Pathways An Adverse Outcome Pathway Framework for Neural Tube and Axial Defects Mediated by Modulation of Retinoic Acid Homeostasis. ICCA-LRI and U.S. EPA Workshop: What will work? Application of new approaches for chemical safety assessment. New Orleans LA, USA, June 16-17, 2015.
  Lectures - 2009
A.H. Piersma (12.03.2009) Beoordeling van reproductietoxiciteit van chemische stoffen: de centrale plaats van de blootstellingsperiode in de reproductiecyclus
A.H. Piersma (02.07.2009) Computational toxicology: challenges for regulatory toxicology and legislation
A.H. Piersma (26.03.2009) Embryonic stem cells and trancriptomics in developmental toxicity testing
A.H. Piersma (01.06.2009) The extended one-generation reproduction toxicity study: saving animals and improving hazard assessment?
A.H. Piersma (10.09.2009) Whole embryo cultures
   Editorial activity - 0
A.H. Piersma () Reproductive Toxicology
A.H. Piersma () Reproductive Toxicology
  Contribution to the work of national or international committees and working groups - 0
A.H. Piersma () Lid gezondheidraadcommissie Gezondheisbescherming Beroepsmatige Blootstelling Stoffen
A.H. Piersma () Member EU Scientific Committe SCENIHR working group BPA
A.H. Piersma () Member EU Scientific Committee SCENIHR working group phtalates
A.H. Piersma () Scientific advisor, ILSI-HESI-Developmental and Reproductive Toxicity task force
A.H. Piersma () Voorzitter gezondheidsraadsubcommissie Classificatie en Labelling Reproductietoxische stoffen
  Research and Teaching at External Organisation - 2015
A.H. Piersma (09.09.2015) Developmental immunotoxicity testing. Berlin SafeSciMed Toxicology Course Lecture, 9 September 2015.
  Invited talk - 2016
Piersma, A.H. (27.05.2016) Invited speaker Vereniging Proefdiervrij Plooien en Vouwen
  Prize (including medals and awards) - 0
Piersma, A.H. 2011 Recipient Best paper in the area of risk assessment 2010: Louisse, J. (et al) The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man. Toxicol Sci 118, 470-484
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Gegenereerd op 2018-07-20 02:37:19
Full name
prof. dr. A.H. Piersma Contact details
Nieuw Gildestein

Yalelaan 2
Room -
3584 CM  UTRECHT
The Netherlands


Jeannette Donker-Voetgebouw

Yalelaan 104-106
Room -
3584 CM  UTRECHT
The Netherlands


Phone number (direct) +31 30 274 2526
Gegenereerd op 2018-07-20 02:37:19
Last updated 08.09.2014