Dr. ing. T. (Tom) Wennekes

Dr. ing. T. (Tom) Wennekes

Universitair docent
Chemical Biology and Drug Discovery
06 39 015 424
t.wennekes@uu.nl

See my Google Scholar profile for an up to date overview of my publications

Publicaties

2022

Wetenschappelijke publicaties

Luijkx, Y. M. C. A., Henselijn, A. J., Bosman, G. P., Cramer, D. A. T., Giesbers, K. C. A. P., van't Veld, E. M., Boons, G-J., Heck, A. J. R., Reiding, K. R., Strijbis, K., & Wennekes, T. (2022). Detection of Bacterial alpha-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts. Molecules, 27(5), 1-15. https://doi.org/10.3390/molecules27051615
de Saint Aulaire, P., Hoogenboom, J., Uiterweerd, M. T., Zuilhof, H., & Wennekes, T. (2022). Synthetic Strategy towards a Carbocyclic N-Acetylneuraminic Acid. European Journal of Organic Chemistry, 2022(27), [e202200297]. https://doi.org/10.1002/ejoc.202200297
de Jong, H., Moure, M. J., Hartman, J. E. M., Bosman, G. P., Ong, J. Y., Bardoel, B. W., Boons, G-J., Wosten, M. M. S. M., & Wennekes, T. (2022). Selective Exoenzymatic Labeling of Lipooligosaccharides of Neisseria gonorrhoeae with α2,6-Sialoside Analogues. ChemBioChem, 23(19), [e202200340]. https://doi.org/10.1002/cbic.202200340
Luijkx, Y. M. C. A., Henselijn, A. J., Bosman, G. P., Cramer, D. A. T., Giesbers, K. C. A. P., van 't Veld, E. M., Boons, G-J., Heck, A. J. R., Reiding, K. R., Strijbis, K., & Wennekes, T. (2022). Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts. Molecules (Basel, Switzerland), 27(5), [1615]. https://doi.org/10.3390/molecules27051615
de Jong, H., Wösten, M. M. S. M., & Wennekes, T. (2022). Sweet impersonators: Molecular mimicry of host glycans by bacteria. Glycobiology, 32(1), 11-22. https://doi.org/10.1093/glycob/cwab104

2021

Wetenschappelijke publicaties

Meng, X., Boons, G-J., Wösten, M., & Wennekes, T. (2021). Metabolic Labeling of Legionaminic acid in Flagellin Glycosylation of Campylobacter jejuni Identifies Maf4 as a Putative Legionaminyl Transferase. Angewandte Chemie-International Edition, 60(47), 24811-24816. https://doi.org/10.1002/anie.202107181
Dai, M., Du, W., Martínez-Romero, C., Leenders, T., Wennekes, T., Rimmelzwaan, G. F., van Kuppeveld, F. J. M., Fouchier, R. A. M., Garcia-Sastre, A., de Vries, E., & de Haan, C. A. M. (2021). Analysis of the Evolution of Pandemic Influenza A(H1N1) Virus Neuraminidase Reveals Entanglement of Different Phenotypic Characteristics. mBio, 12(3), 1-18. [e00287-21]. https://doi.org/10.1128/mBio.00287-21
Heesterbeek, D. A. C., Muts, R. M., Hensbergen, V. P. V., Aulaire, P. D. S., Wennekes, T., Bardoel, B. W., Sorge, N. M. V., & Rooijakkers, S. H. M. (2021). Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes. PLoS Pathogens, 17(1), 1-22. [e1009227]. https://doi.org/10.1371/journal.ppat.1009227
Tas, R. P., Sampaio-Pinto, V., Wennekes, T., van Laake, L. W., & Voets, I. K. (2021). From the freezer to the clinic: Antifreeze proteins in the preservation of cells, tissues, and organs. EMBO Reports, 22(3), [e52162]. https://doi.org/10.15252/embr.202052162
Luijkx, Y. M. C. A., Jongkees, S., Strijbis, K., & Wennekes, T. (2021). Development of a 1,2-difluorofucoside activity-based probe for profiling GH29 fucosidases. Organic & Biomolecular Chemistry, 19(13), 2968-2977. https://doi.org/10.1039/d1ob00054c

2020

Wetenschappelijke publicaties

Luijkx, Y., Bleumink, N., Jiang, J., Overkleeft, H. S., Wösten, M., Strijbis, K., & Wennekes, T. (Accepted/In press). Bacteroides fragilis fucosidases facilitate growth and invasion of Campylobacter jejuni in the presence of mucins. Cellular Microbiology. https://doi.org/10.1111/cmi.13252

2019

Wetenschappelijke publicaties

Broszeit, F., Tzarum, N., Zhu, X., Nemanichvili, N., Eggink, D., Leenders, T., Li, Z., Liu, L., Wolfert, M. A., Papanikolaou, A., Martínez-Romero, C., Gagarinov, I. A., Yu, W., García-Sastre, A., Wennekes, T., Okamatsu, M., Verheije, M. H., Wilson, I. A., Boons, G-J., & de Vries, R. P. (2019). N-Glycolylneuraminic Acid as a Receptor for Influenza A Viruses. Cell Reports, 27(11), 3284-3294.e6. https://doi.org/10.1016/j.celrep.2019.05.048

2018

Wetenschappelijke publicaties

CAZypedia Consortium, & Wennekes, T. (2018). Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes. Glycobiology, 28(1), 3-8. https://doi.org/10.1093/glycob/cwx089

2017

Wetenschappelijke publicaties

Lahav, D., Liu, B., van den Berg, R. J. B. H. N., van den Nieuwendijk, A. M. C. H., Wennekes, T., Ghisaidoobe, A. B. T., Breen, I., Ferraz, M. J., Kuo, C-L., Wu, L., Geurink, P. P., Ovaa, H., van der Marel, G. A., van der Stelt, M., Boot, R. G., Davies, G. J., Aerts, J. M. F. G., & Overkleeft, H. S. (2017). A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase. Journal of the American Chemical Society, 139(40), 14192-14197. https://doi.org/10.1021/jacs.7b07352
Gahtory, D., Murtola, M., Smulders, M. M. J., Wennekes, T., Zuilhof, H., Strömberg, R., & Albada, B. (2017). Facile functionalization of peptide nucleic acids (PNAs) for antisense and single nucleotide polymorphism detection. Organic and Biomolecular Chemistry, 15(32), 6710-6714. https://doi.org/10.1039/c7ob01592e
Fiers, M., Hoogenboom, J., Brunazzi, A., Wennekes, T., Angenent, G. C., & Immink, R. G. H. (2017). A plant-based chemical genomics screen for the identification of flowering inducers. Plant Methods, 13, [78]. https://doi.org/10.1186/s13007-017-0230-2

2016

Wetenschappelijke publicaties

Arns, S., Tan, J., Sun, S., Galey, A., Zisman, N., Ross, F., Udechukwu, J., Dercho, S., Gusti, V., Paquette, J., Wennekes, T., Webb, M., Bourque, E., Withers, S. G., & Liggins, R. (2016). Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay (vol 25, pg 2505, 2015). Bioorganic & Medicinal Chemistry Letters, 26(15), 3830-3830. https://doi.org/10.1016/j.bmcl.2016.06.068
Hoogenboom, J., Berghuis, N., Cramer, D., Geurts, R., Zuilhof, H., & Wennekes, T. (2016). Direct imaging of glycans in Arabidopsis roots via click labeling of metabolically incorporated azido-monosaccharides. BMC Plant Biology, 16, [220]. https://doi.org/10.1186/s12870-016-0907-0
Arns, S., Tan, J., Sun, S., Galey, A., Zisman, N., Ross, F., Udechukwu, J., Dercho, S., Gusti, V., Paquette, J., Wennekes, T., Webb, M., Bourque, E., Withers, S. G., & Liggins, R. (2016). Erratum: Corrigendum to “Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay” (Bioorg. Med. Chem. Lett. (2015) 25 (2505–2509)). Bioorganic and Medicinal Chemistry Letters, 26(15), 3830. https://doi.org/10.1016/j.bmcl.2016.06.068
Hoogenboom, J., Fiers, M., Immink, R., Zuilhof, H., & Wennekes, T. (2016). Synthesis and evaluation of locostatin-based chemical probes towards PEBP-proteins. Tetrahedron Letters, 57(22), 2406-2409. https://doi.org/10.1016/j.tetlet.2016.04.071
Van Den Berg, S. A., Zuilhof, H., & Wennekes, T. (2016). Clickable Polylactic Acids by Fast Organocatalytic Ring-Opening Polymerization in Continuous Flow. Macromolecules, 49(6), 2054-2062. https://doi.org/10.1021/acs.macromol.5b02533
Sminia, T. J., Zuilhof, H., & Wennekes, T. (2016). Getting a grip on glycans: A current overview of the metabolic oligosaccharide engineering toolbox. Carbohydrate Research, 435, 121-141. https://doi.org/10.1016/j.carres.2016.09.007
Hoogenboom, J., Lutz, M., Zuilhof, H., & Wennekes, T. (2016). Exploring the Chemistry of Bicyclic Isoxazolidines for the Multicomponent Synthesis of Glycomimetic Building Blocks. Journal of Organic Chemistry, 81(19), 8826-8836. https://doi.org/10.1021/acs.joc.6b01515

2015

Wetenschappelijke publicaties

Van Den Berg, S. A., Frijns, R. A. M., Wennekes, T., & Zuilhof, H. (2015). Continuous-flow alcohol protection and deprotection reactions catalyzed by silica-supported sulfonic acid. Journal of Flow Chemistry, 5(2), 95-100. https://doi.org/10.1556/1846.2015.00006
Debrassi, A., De Vos, W. M., Zuilhof, H., & Wennekes, T. (2015). Carbohydrate-Presenting Self-Assembled Monolayers: Preparation, Analysis, and Applications in Microbiology. In Carbohydrate Nanotechnology (pp. 1-51). Wiley-Blackwell. https://doi.org/10.1002/9781118860212.ch1
Debrassi, A., Roeven, E., Thijssen, S., Scheres, L., De Vos, W. M., Wennekes, T., & Zuilhof, H. (2015). Versatile (bio)functionalization of bromo-terminated phosphonate-modified porous aluminum oxide. Langmuir, 31(20), 5633-5644. https://doi.org/10.1021/acs.langmuir.5b00853
Hoogenboom, J., Zuilhof, H., & Wennekes, T. (2015). Versatile Scope of a Masked Aldehyde Nitrone in 1,3-Dipolar Cycloadditions. Organic Letters, 17(22), 5550-5553. https://doi.org/10.1021/acs.orglett.5b02662
Vandenberg, R. J. B. H. N., Vanrijssel, E. R., Ferraz, M. J., Houben, J., Strijland, A., Donker-Koopman, W. E., Wennekes, T., Bonger, K. M., Ghisaidoobe, A. B. T., Hoogendoorn, S., Vandermarel, G. A., Codée, J. D. C., Overkleeft, H. S., & Aerts, J. M. F. G. (2015). Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors. ChemMedChem, 10(12), 2042-2062. https://doi.org/10.1002/cmdc.201500407

2014

Wetenschappelijke publicaties

Debrassi, A., Ribbera, A., de Vos, W. M., Wennekes, T., & Zuilhof, H. (2014). Stability of (Bio)Functionalized Porous Aluminum Oxide. Langmuir. https://doi.org/10.1021/la403525z
van den Berg, S. A., Alonso, J. M., Wadhwa, K., Franssen, M. C. R., Wennekes, T., & Zuilhof, H. (2014). Microwave-Assisted Formation of Organic Mono layers from 1-Alkenes on Silicon Carbide. Langmuir. https://doi.org/10.1021/la502197q
Kallemeijn, W. W., Witte, M. D., Wennekes, T., & Aerts, J. M. F. G. (2014). Mechanism-based inhibitors of glycosidases: design and applications. Advances in Carbohydrate Chemistry and Biochemistry. https://doi.org/10.1016/B978-0-12-800128-8.00004-2
Ghisaidoobe, A. T., van den Berg, R. J. B. H. N., Butt, S. S., Strijland, A., Donker-Koopman, W. E., Scheij, S., van den Nieuwendijk, A. M. C. H., Koomen, G-J., van Loevezijn, A., Leemhuis, M., Wennekes, T., van der Stelt, M., van der Marel, G. A., van Boeckel, C. A. A., Aerts, J. M. F. G., & Overkleeft, H. S. (2014). Identification and Development of Biphenyl Substituted Iminosugars as Improved Dual Glucosylceramide Synthase/Neutral Glucosylceramidase Inhibitors. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm501181z
Bhairamadgi, N. S., Pujari, S. P., Trovela, F. G., Debrassi, A., Khamis, A. A., Alonso, J. M., Al Zahrani, A. A., Wennekes, T., Al-Turaif, H. A., van Rijn, C., Alhamed, Y. A., & Zuilhof, H. (2014). Hydrolytic and Thermal Stability of Organic Mono layers on Various Inorganic Substrates. Langmuir. https://doi.org/10.1021/la500533f
Manova, R. K., Joshi, S., Debrassi, A., Bhairamadgi, N. S., Roeven, E., Gagnon, J., Tahir, M. N., Claassen, F. W., Scheres, L. M. W., Wennekes, T., Schroen, K., van Beek, T. A., Zuilhof, H., & Nielen, M. W. F. (2014). Ambient Surface Analysis of Organic Monolayers using Direct Analysis in Real Time Orbitrap Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/ac4031626
Branson, T. R., McAllister, T. E., Garcia-Hartjes, J., Fascione, M. A., Ross, J. F., Warriner, S. L., Wennekes, T., Zuilhof, H., & Turnbull, W. B. (2014). A Protein-Based Pentavalent Inhibitor of the Cholera Toxin B-Subunit. Angewandte Chemie-International Edition. https://doi.org/10.1002/anie.201404397
Van Den Berg, S. A., Tu, J., Sliedregt, K. M., Kros, A., Wennekes, T., & Zuilhof, H. (2014). Clickable Mesoporous Silica via Functionalization with 1,ω-Alkenes. Advanced Materials Interfaces, 1(3), [1300061]. https://doi.org/10.1002/admi.201300061

2013

Wetenschappelijke publicaties

Bernardi, A., Jimenez-Barbero, J., Casnati, A., De Castro, C., Darbre, T., Fieschi, F., Finne, J., Funken, H., Jaeger, K-E., Lahmann, M., Lindhorst, T. K., Marradi, M., Messner, P., Molinaro, A., Murphy, P. V., Nativi, C., Oscarson, S., Penades, S., Peri, F., ... Imberty, A. (2013). Multivalent glycoconjugates as anti-pathogenic agents. Chemical Society Reviews. https://doi.org/10.1039/c2cs35408j
Garcia-Hartjes, J., Dommerholt, J., Wennekes, T., van Delft, F. L., & Zuilhof, H. (2013). Electronic Effects versus Distortion Energies During Strain-Promoted Alkyne-Azide Cycloadditions: A Theoretical Tool to Predict Reaction Kinetics. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.201201627
Mattarella, M., Garcia-Hartjes, J., Wennekes, T., Zuilhof, H., & Siegel, J. S. (2013). Nanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes. Organic & Biomolecular Chemistry. https://doi.org/10.1039/c3ob40438b
Garcia-Hartjes, J., Bernardi, S., Weijers, C. A. G. M., Wennekes, T., Gilbert, M., Sansone, F., Casnati, A., & Zuilhof, H. (2013). Picomolar inhibition of cholera toxin by a pentavalent ganglioside GM1os-calix[5]arene. Organic & Biomolecular Chemistry. https://doi.org/10.1039/c3ob40515j
Kim, J. H., Resende, R., Wennekes, T., Chen, H. M., Bance, N., Buchini, S., Watts, A. G., Pilling, P., Streltsov, V. A., Petric, M., Liggins, R., Barrett, S., McKimm-Breschkin, J. L., Niikura, M., & Withers, S. G. (2013). Mechanism-based covalent neuraminidase inhibitors with broad-spectrum influenza antiviral activity. Science, 340(6128), 71-75. https://doi.org/10.1126/science.1232552

2012

Wetenschappelijke publicaties

Wennekes, T., Bonger, K. M., Vogel, K., van den Berg, R., Strijland, A., Donker-Koopman, W. E., Aerts, J. M. F. G., van der Marel, G. A., & Overkleeft, H. S. (2012). The Development of an Aza-C-Glycoside Library Based on a Tandem Staudinger/Aza-Wittig/Ugi Three-Component Reaction. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.201200923
Thompson, A. J., Williams, R. J., Hakki, Z., Alonzi, D. S., Wennekes, T., Gloster, T. M., Songsrirote, K., Thomas-Oates, J. E., Wrodnigg, T. M., Spreitz, J., Stuetz, A. E., Butters, T. D., Williams, S. J., & Davies, G. J. (2012). Structural and mechanistic insight into N-glycan processing by endo-alpha-mannosidase. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1111482109

2011

Wetenschappelijke publicaties

Aerts, J. M., Boot, R. G., van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F. M., Dekker, N., Groen, A. K., Ottenhoff, R., van Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., Overkleeft, H. S., & Cowart, LA. (2011). GLYCOSPHINGOLIPIDS AND INSULIN RESISTANCE. Sphingolipids and Metabolic Disease.
Aerts, J. M. F. G., Boot, R. G., Van Eijk, M., Groener, J., Bijl, N., Lombardo, E., Bietrix, F. M., Dekker, N., Groen, A. K., Ottenhoff, R., Van Roomen, C., Aten, J., Serlie, M., Langeveld, M., Wennekes, T., & Overkleeft, H. S. (2011). Glycosphingolipids and insulin resistance. https://doi.org/10.1007/978-1-4614-0650-1_7
Dekker, N., Voorn-Brouwer, T., Verhoek, M., Wennekes, T., Narayan, R. S., Speijer, D., Hollak, C. E. M., Overkleeft, H. S., Boot, R. G., & Aerts, J. M. F. G. (2011). The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation. Blood Cells Molecules and Diseases. https://doi.org/10.1016/j.bcmd.2010.07.009
van den Berg, R. J. B. H. N., Wennekes, T., Ghisaidoobe, A., Donker-Koopman, W. E., Strijland, A., Boot, R. G., van der Marel, G. A., Aerts, J. M. F. G., & Overkleeft, H. S. (2011). Assessment of Partially Deoxygenated Deoxynojirimycin Derivatives as Glucosylceramide Synthase Inhibitors. ACS Medicinal Chemistry Letters. https://doi.org/10.1021/ml200050s
Pukin, A. V., Florack, D. E. A., Brochu, D., van Lagen, B., Visser, G. M., Wennekes, T., Gilbert, M., & Zuilhof, H. (2011). Chemoenzymatic synthesis of biotin-appended analogues of gangliosides GM2, GM1, GD1a and GalNAc-GD1a for solid-phase applications and improved ELISA tests. Organic & Biomolecular Chemistry. https://doi.org/10.1039/c1ob00009h

2010

Wetenschappelijke publicaties

Dinkelaar, J., Duivenvoorden, B. A., Wennekes, T., Overkleeft, H. S., Boot, R. G., Aerts, J. M. F. G., Codee, J. D. C., & van der Marel, G. A. (2010). A Preparative Synthesis of Human Chitinase Fluorogenic Substrate (4'-Deoxychitobiosyl)-4-methylumbelliferone. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.201000080
Wennekes, T., Meijer, A. J., Groen, A. K., Boot, R. G., Groener, J. E., van Eijk, M., Ottenhoff, R., Bijl, N., Ghauharali, K., Song, H., O'Shea, T. J., Liu, H., Yew, N., Copeland, D., van den Berg, R. J., van der Marel, G. A., Overkleeft, H. S., & Aerts, J. M. (2010). Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation. Journal of Medicinal Chemistry. https://doi.org/10.1021/jm901281m
Wennekes, T., van den Berg, R. J. B. H. N., Boltje, T. J., Donker-Koopman, W. E., Kuijper, B., van der Marel, G. A., Strijland, A., Verhagen, C. P., Aerts, J. M. F. G., & Overkleeft, H. S. (2010). Synthesis and Evaluation of Lipophilic Aza-C-glycosides as Inhibitors of Glucosylceramide Metabolism. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.200901208
Goddard-Borger, E. D., Wennekes, T., & Withers, S. G. (2010). MOLECULAR PROBES Getting lucky in the lysosome. Nature Chemical Biology. https://doi.org/10.1038/nchembio.470

2009

Wetenschappelijke publicaties

Wennekes, T., van den Berg, R. J. B. H. N., Boot, R. G., van der Marel, G. A., Overkleeft, H. S., & Aerts, J. M. F. G. (2009). Glycosphingolipids-Nature, Function, and Pharmacological Modulation. Angewandte Chemie-International Edition. https://doi.org/10.1002/anie.200902620
Wennekes, T., van den Berg, R. J. B. H. N., Bonger, K. M., Donker-Koopman, W. E., Ghisaidoobe, A., van der Marel, G. A., Strijland, A., Aerts, J. M. F. G., & Overkleeft, H. S. (2009). Synthesis and evaluation of dimeric lipophilic iminosugars as inhibitors of glucosylceramide metabolism. Tetrahedron-Asymmetry. https://doi.org/10.1016/j.tetasy.2009.02.043

2008

Wetenschappelijke publicaties

Wennekes, T., Lang, B., Leeman, M., van der Marel, G. A., Smits, E., Weber, M., van Wiltenburg, J., Wolberg, M., Aerts, J. M. F. G., & Overkleeft, H. S. (2008). Large-scale synthesis of the glucosylceramide synthase inhibitor N[5-(adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin. Organic Process Research & Development. https://doi.org/10.1021/op700295x
Bonger, K. M., Wennekes, T., Filippov, D. V., Lodder, G., van der Marel, G. A., & Overkleeft, H. S. (2008). The effect of Lewis acids on the stereochemistry in the Ugi three-component reaction with D-lyxo-pyrroline. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.200800340

2007

Wetenschappelijke publicaties

Bussink, A. P., van Swieten, P. F., Ghauharali, K., Scheij, S., van Eijk, M., Wennekes, T., van der Marel, G. A., Boot, R. G., Aerts, J. M. F. G., & Overkleeft, H. S. (2007). N-Azidoacetylmannosamine-mediated chemical tagging of gangliosides. Journal of Lipid Research. https://doi.org/10.1194/jlr.C700006-JLR200
Wennekes, T., van den Berg, R. J. B. H. N., Donker, W., van der Marel, G. A., Strijland, A., Aerts, J. M. F. G., & Overkleeft, H. S. (2007). Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man. Journal of Organic Chemistry. https://doi.org/10.1021/jo061280p
Boot, R. G., Verhoek, M., Donker-Koopman, W., Strijland, A., van Marle, J., Overkleeft, H. S., Wennekes, T., & Aerts, J. M. F. G. (2007). Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M610544200
Aerts, J. M., Ottenhoff, R., Powlson, A. S., Grefhorst, A., van Eijk, M., Dubbelhuis, P. F., Aten, J., Kuipers, F., Serlie, M. J., Wennekes, T., Sethi, J. K., O'Rahilly, S., & Overkleeft, H. S. (2007). Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes. https://doi.org/10.2337/db06-1619

2006

Wetenschappelijke publicaties

Bonger, K. M., Wennekes, T., de Lavoir, S. V. P., Esposito, D., van den Berg, R. J. B. H. N., Litjens, R. E. J. N., & van der Marel, G. A. (2006). Transformation of carbohydrate derived 4-azidopentanals into highly functionalized pyrrolidines Via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction. QSAR & Combinatorial Science. https://doi.org/10.1002/qsar.200540198

2004

Wetenschappelijke publicaties

Verhelst, SHL., Magnee, ME., Wennekes, T., Wiedenhof, W., van der Marel, GA., Overkleeft, H. S., van Boeckel, CAA., & van Boom, JH. (2004). Glycosylation of cyclitols: Synthesis of neamine-type aminoglycosides. European Journal of Organic Chemistry. https://doi.org/10.1002/ejoc.200400020
Verhelst, SHL., Wennekes, T., van der Marel, GA., Overkleeft, H. S., van Boeckel, CAA., & van Boom, JH. (2004). Synthesis of orthogonally protected 2-deoxystreptamine stereoisomers. Tetrahedron. https://doi.org/10.1016/j.tet.2004.01.063