Sleutelpublicaties
Tryfonidou, M. A., de Vries, G., Hennink, W. E., & Creemers, L. B. (2020). "Old Drugs, New Tricks" - Local controlled drug release systems for treatment of degenerative joint disease. Advanced Drug Delivery Reviews, 160, 170-185. https://doi.org/10.1016/j.addr.2020.10.012
Bach, F. C., Tellegen, A. R., Beukers, M., Miranda-Bedate, A., Teunissen, M., de Jong, W. A. M., de Vries, S. A. H., Creemers, L. B., Benz, K., Meij, B. P., Ito, K., & Tryfonidou, M. A. (2018). Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside. Oncotarget, 9(41), 26507-26526. https://doi.org/10.18632/oncotarget.25476
Bach, F. C., de Vries, S. A., Krouwels, A., Creemers, L. B., Ito, K., Meij, B. P., & Tryfonidou, M. A. (2015). The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs. European Cells & Materials [E], 30, 132-147.
https://dspace.library.uu.nl/bitstream/handle/1874/327195/NCCM_species.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/327195/NCCM_species.pdf?sequence=1
Bach, F., Libregts, S., Creemers, L. B., Meij, B., Ito, K., Wauben, M., & Tryfonidou, M. (2017). Notochordal-cell derived extracellular vesicles exert regenerative effects on canine and human nucleus pulposus cells. Oncotarget, 8(51), 88845-88856. https://doi.org/10.18632/oncotarget.21483
Smolders, L. A., Bergknut, N., Grinwis, G. C. M., Hagman, R., Lagerstedt, A. S., Hazewinkel, H. A. W., Tryfonidou, M. A., & Meij, B. P. (2013). Intervertebral disc degeneration in the dog. Part 2: Chondrodystrophic and non-chondrodystrophic breeds. Veterinary Journal, 195, 292-299. https://doi.org/10.1016/j.tvjl.2012.10.011.
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Houweling, M., Groot Koerkamp, M. J. A., van Leenen, D., Holstege, F. C. P., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research & Therapy, 15(1), R23. https://doi.org/10.1186/ar4157
Bach, F. C., de Vries, S. A., Riemers, F. M., Boere, J., van Heel, F. W., van Doeselaar, M., Goerdaya, S. S., Nikkels, P. G., Benz, K., Creemers, L. B., Maarten Altelaar, A. F., Meij, B. P., Ito, K., & Tryfonidou, M. A. (2016). Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration. European Cells & Materials [E], 32, 163-80. https://doi.org/10.22203/eCM.v0 32 a11
Tellegen, A. R., Dessing, A. J., Houben, K., Riemers, F. M., Creemers, L. B., Mastbergen, S. C., Meij, B. P., Miranda-Bedate, A., & Tryfonidou, M. A. (2019). Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter. Journal of Orthopaedic Research, 37(12), 2550-2560. https://doi.org/10.1002/jor.24432
Tellegen, A. R., Willems, N., Beukers, M., Grinwis, G. C. M., Plomp, S. G. M., Bos, C., van Dijk, M., de Leeuw, M., Creemers, L. B., Tryfonidou, M. A., & Meij, B. P. (2018). Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: what's in it for humans? Journal of Tissue Engineering and Regenerative Medicine. https://doi.org/10.1002/term.2483
Publicaties
2021
Wetenschappelijke publicaties
Teunissen, M., Verseijden, F., Riemers, F. M., van Osch, G. J. V. M., & Tryfonidou, M. A. (2021). The lower in vitro chondrogenic potential of canine adipose tissue-derived mesenchymal stromal cells (MSC) compared to bone marrow-derived MSC is not improved by BMP-2 or BMP-6. Veterinary Journal, 269, 105605. https://doi.org/10.1016/j.tvjl.2020.105605
2020
Wetenschappelijke publicaties
Tryfonidou, M. A., de Vries, G., Hennink, W. E., & Creemers, L. B. (2020). "Old Drugs, New Tricks" - Local controlled drug release systems for treatment of degenerative joint disease. Advanced Drug Delivery Reviews, 160, 170-185. https://doi.org/10.1016/j.addr.2020.10.012
Schmitz, T. C., Salzer, E., Crispim, J. F., Fabra, G. T., LeVisage, C., Pandit, A., Tryfonidou, M., Maitre, C. L., & Ito, K. (2020). Characterization of Biomaterials Intended for Use in the Nucleus Pulposus of Degenerated Intervertebral Discs. Acta Biomaterialia, 114, 1-15. https://doi.org/10.1016/j.actbio.2020.08.001
Krouwels, A., Iljas, J. D., Kragten, A. H. M., Dhert, W. J. A., Öner, F. C., Tryfonidou, M. A., & Creemers, L. B. (2020). Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration. International Journal of Molecular Sciences, 21(8). https://doi.org/10.3390/ijms21082720
Quiros, N., Abinzano, F., Plomp, S., Giessen, E., Levato, R., Tryfonidou, M., & Moller, N. T. (2020). Combination of bone morphogenetic protein 9 and transforming growth factor BETA-1 improves cartilaginous matrix formation by equine chondrocytes in three-dimensional culture. Osteoarthritis and Cartilage, 28(Supplement 1), [S496]. https://doi.org/10.1016/j.joca.2020.02.776
Korpershoek, J., Rikkers, M., De Windt, T. S., Tryfonidou, M. A., Saris, D. B. F., & Vonk, L. A. (2020). Progenitor cells with high chondrogenic potential are present in the adult human meniscus. Osteoarthritis and Cartilage, 28(suppl. 1), S205-S206. https://doi.org/10.1016/j.joca.2020.02.334
Teunissen, M., Popov-Celeketic, J., Coeleveld, K., Meij, B. P., Lafeber, F. P., Tryfonidou, M. A., & Mastbergen, S. C. (2020). Knee joint distraction-induced shift from catabolic to anabolic state occurs after the distraction period. Osteoarthritis and Cartilage, 28(suppl. 1), S76-S77. [86]. https://doi.org/10.1016/j.joca.2020.02.116
Bergmann, W., van de Lest, C., Tryfonidou, M., Groene, A., Wijnberg, I., Back, W., Vernooij, H., Plomp, S., & Grinwis, G. (2020). Of French Fries and Horses: Biochemical Changes in Equine Intervertebral Disc Degeneration. Journal of Comparative Pathology, 174, 150. https://doi.org/10.1016/j.jcpa.2019.10.032
Fusellier, M., Clouet, J., Gauthier, O., Tryfonidou, M., Le Visage, C., & Guicheux, J. (2020). Degenerative lumbar disc disease: in vivo data support the rationale for the selection of appropriate animal models. European Cells and Materials, 39, 18-47. https://doi.org/10.22203/eCM.v039a02
2019
Wetenschappelijke publicaties
Rudnik-Jansen, I., Tellegen, A. R., Pouran, B., Schrijver, K., Meij, B. P., Emans, P. J., de Gendt, E., Thomas, R. E., Kik, M. J. L., de Visser, H. M., Weinans, H., Egas, A., van Maarseveen, E., Woike, N., Mihov, G., Thies, J., Tryfonidou, M. A., & Creemers, L. B. (2019). Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing. British Journal of Pharmacology, 176(20), 4050-4064. https://doi.org/10.1111/bph.14817
Teunissen, M., Popov-Celeketic, J., Coeleveld, K., Meij, B., Lafeber, F. P. J. G., Tryfonidou, M. A., & Mastbergen, S. C. (2019). The catabolic-to-anabolic shift in the osteoarthritic cartilage after knee joint distraction in dogs occurs after the distraction period. In eCM Periodical, 2019, Collection 3; 2019 TERMIS EU Abstracts (pp. 657) https://www.ecmconferences.org/abstracts/2019/Collection3/collection3.pdf
Bach, F. C., de Rooij, K. M., Riemers, F. M., Snuggs, J. W., de Jong, W. A. M., Zhang, Y., Creemers, L. B., Chan, D., Le Maitre, C., & Tryfonidou, M. A. (2019). Hedgehog proteins and parathyroid hormone-related protein are involved in intervertebral disc maturation, degeneration, and calcification. Spine, 2(4), [e1071]. https://doi.org/10.1002/jsp2.1071
Tellegen, A. R., Dessing, A. J., Houben, K., Riemers, F. M., Creemers, L. B., Mastbergen, S. C., Meij, B. P., Miranda-Bedate, A., & Tryfonidou, M. A. (2019). Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter. Journal of Orthopaedic Research, 37(12), 2550-2560. https://doi.org/10.1002/jor.24432
Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A., & Creemers, L. B. (2019). Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis. Journal of Controlled Release, 294, 247-258. https://doi.org/10.1016/j.jconrel.2018.12.030
Quiros, N., Giessen, E., Plomp, S. G. M., Abinzano, F., Tryfonidou, M. A., & te Moller, N. C. R. (2019). The influence of synovial fluid derived from equine joints with acute and chronic pathologies on in vitro chondrogenesis. Poster session presented at Veterinary Science Day , Bunnik, Netherlands.
Quiros, N., Abinzano, F., Plomp, S. G. M., Giessen, E., Levato, R., Tryfonidou, M. A., & te Moller, N. C. R. (2019). Synergy around equine chondrocyte pellets: Improving cartilaginous matrix formation in three-dimensional culture by a combination of BMP9 and TGFb1. Poster session presented at Veterinary Science Day , Bunnik, Netherlands.
Bergmann, W., van de Lest, C. H. A., Tryfonidou, M. A., Gröne, A., Wijnberg, I. D., Back, W., Vernooij, J. C. M., Plomp, S. G. M., & Grinwis, G. C. M. (2019). Of French Fries and Horses Biochemical Changes in Equine Intervertebral Disc Degeneration.
Veterinary Science Day, Veterinary Faculty, UU, .
Veterinary Science Day, Veterinary Faculty, UU, .
Bergmann, W., van de Lest, C. H. A., Tryfonidou, M. A., Gröne, A., Wijnberg, I. D., Vernooij, J. C. M., Plomp, S. G. M., & Grinwis, G. C. M. (2019). Of French Fries and Horses Biochemical Changes in Equine Intervertebral Disc Degeneration. Poster session presented at Joint congress of veterinary pathology and veterinary clinical pathology, Arnhem, Netherlands.
Snuggs, J. W., Day, R. E., Bach, F. C., Conner, M. T., Bunning, R. A. D., Tryfonidou, M. A., & Le Maitre, C. L. (2019). Aquaporin expression in the human and canine intervertebral disc during maturation and degeneration. Spine, 2(1), [1049]. https://doi.org/10.1002/jsp2.1049
Frauchiger, D. A., Tekari, A., May, R. D., Džafo, E., Chan, S. C. W., Stoyanov, J., Bertolo, A., Zhang, X., Guerrero, J., Sakai, D., Schol, J., Grad, S., Tryfonidou, M., Benneker, L. M., & Gantenbein, B. (2019). Fluorescence-Activated Cell Sorting Is More Potent to Fish Intervertebral Disk Progenitor Cells Than Magnetic and Beads-Based Methods. Tissue Engineering - Part C: Methods, 25(10), 571-580. https://doi.org/10.1089/ten.tec.2018.0375
Reints Bok, T. E., Willemsen, K., van Rijen, M. H. P., Grinwis, G. C. M., Tryfonidou, M. A., & Meij, B. P. (2019). Instrumented cervical fusion in nine dogs with caudal cervical spondylomyelopathy. Veterinary Surgery, 48, 1287-1298. https://doi.org/10.1111/vsu.13312
van Helvoort, E. M., Popov-Celeketic, J., Eijkelkamp, N., Coeleveld, K., Tryfonidou, M. A., Wijne, C. D., Hack, C. E., Lafeber, F. P. J. G., & Mastbergen, S. C. (2019). Canine IL4-10 fusion protein provides disease modifying activity in a canine model of OA: an exploratory study. PLoS One, 14(7), [e0219587]. https://doi.org/10.1371/journal.pone.0219587
Rudnik-Jansen, I., Woike, N., de Jong, S., Versteeg, S., Kik, M., Emans, P., Mihov, G., Thies, J. C., Eijkelkamp, N., Tryfonidou, M. A., & Creemers, L. B. (2019). Intra-articular injection of triamcinolone acetonide in a sustained release polyesteramide formulation shows prolonged anti-inflammatory efficacy in a rat model. Osteoarthritis and Cartilage, 27(S1), S418-S419. https://doi.org/10.1016/j.joca.2019.02.433
Rudnik-Jansen, I., Tellegen, A., Beukers, M., Öner, F., Woike, N., Mihov, G., Thies, J., Meij, B., Tryfonidou, M., & Creemers, L. (2019). Safety of intradiscal delivery of triamcinolone acetonide by a poly(esteramide) microsphere platform in a large animal model of intervertebral disc degeneration. Spine Journal, 19(5), 905-919. https://doi.org/10.1016/j.spinee.2018.10.014
Korthagen, N. M., de Visser, H. M., Geusebroek, G., Storm, G., Dupuis, N., Plomp, S. G., Warmink, K., Eijkelkamp, N., Tryfonidou, M., van Weeren, P. R., & Weinans, H. (2019). Intra-articular treatment with triamcinolone acetonide-loaded liposomes in the rat high-fat diet groove model. Osteoarthritis and Cartilage, 27(Supplement 1), S373-S374. https://doi.org/10.1016/j.joca.2019.02.366
Rudnik-Jansen, I., Schrijver, K., Woike, N., Tellegen, A., Versteeg, S., Emans, P., Mihov, G., Thies, J., Eijkelkamp, N., Tryfonidou, M., & Creemers, L. (2019). Intra-articular injection of triamcinolone acetonide releasing biomaterial microspheres inhibits pain and inflammation in an acute arthritis model. Current Drug Delivery, 26(1), 226-236. https://doi.org/10.1080/10717544.2019.1568625
Del Magno, S., Fracassi, F., Grinwis, G. C. M., Mandrioli, L., Gandini, G., Rossi, F., Sirri, R., Pisoni, L., Tryfonidou, M. A., & Meij, B. P. (2019). Sequential Treatment of a Large Pituitary Corticotroph Neoplasm and Associated Neurological Signs in a Dog. Journal of the American Animal Hospital Association, 55(2), [e55202]. https://doi.org/10.5326/JAAHA-MS-6831
Rudnik-Jansen, I., Woike, N., de Jong, S., Versteeg, S., Kik, M., Emans, P., Mihov, G., Thies, J., Eijkelkamp, N., Tryfonidou, M., & Creemers, L. (2019). Applicability of a Modified Rat Model of Acute Arthritis for Long-Term Testing of Drug Delivery Systems. Molecular Pharmaceutics, 11(2). https://doi.org/10.3390/pharmaceutics11020070
Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M., Tryfonidou, M. A., Yaszemski, M. J., Dhert, W., & Lu, L. (2019). Effect of biomaterial electrical charge on in vivo bone formation. Tissue Engineering. Part A, 25(13/14), 1037-1052. https://doi.org/10.1089/ten.TEA.2018.0140
de Vries, S., Doeselaar, M. V., Meij, B., Tryfonidou, M., & Ito, K. (2019). Notochordal Cell Matrix As a Therapeutic Agent for Intervertebral Disc Regeneration. Tissue Engineering - Part A., 25(11-12), 830-841. https://doi.org/10.1089/ten.tea.2018.0026
2018
Wetenschappelijke publicaties
Tellegen, A. R., Jansen, I., Beukers, M., Miranda-Bedate, A., De Jong, W., Woike, N., Thies, J. C., Mihov, G., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2018). Intradiscal delivery of celecoxib-loaded microspheres restores disc homeostasis in a preclinical canine model of intervertebral disc degeneration. Osteoarthritis and Cartilage, 26, S418-S419. https://doi.org/10.1016/j.joca.2018.02.808
Woike, N., Rudnik-Jansen, I., Tellegen, A., Creemers, L., Tryfonidou, M., Mihov, G., Thies, J. C., Schrijver, K., Versteeg, S. A., & Eijkelkamp, N. (2018). Novel sustained releasing triamcinolone acetonide polyesteramide microparticle platfform to reduce pain in the knee of a synoviatis rat model. Osteoarthritis and Cartilage, 26, S119. https://doi.org/10.1016/j.joca.2018.02.260
Teunissen, M., Riemers, F. M., van Leenen, D., Koerkamp, M. J. G., Meij, B. P., Miranda-Bedate, A., & Tryfonidou, M. A. (2018). Investigating intraspecies differences of the growth plate of small and large breed dogs in order to gain new insights in cartilage biology. In Abstracts from the 2018 OARSI World Congress on Osteoarthritis (Vol. 26, pp. S106). (Osteoarthritis and Cartilage). https://doi.org/10.1016/j.joca.2018.02.232
Sakai, D., Schol, J., Bach, F. C., Tekari, A., Sagawa, N., Nakamura, Y., Chan, S. C. W., Nakai, T., Creemers, L. B., Frauchiger, D. A., May, R. D., Grad, S., Watanabe, M., Tryfonidou, M. A., & Gantenbein, B. (2018). Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species. Spine, 1(2), [e1018]. https://doi.org/10.1002/jsp2.1018
Thorpe, A. A., Bach, F. C., Tryfonidou, M. A., Le Maitre, C. L., Mwale, F., Diwan, A. D., & Ito, K. (2018). Leaping the hurdles in developing regenerative treatments for the intervertebral disc from preclinical to clinical. Spine, 1(3), [e1027]. https://doi.org/10.1002/jsp2.1027
Vastenhout, N., van Rijn, S. J., Riemers, F. M., Tryfonidou, M. A., Meij, B. P., & Penning, L. C. (2018). The mRNA expression of PTTG1 is a strong prognostic indicator for recurrence after hypophysectomy in dogs with corticotroph pituitary adenomas. Veterinary Journal, 240, 19-21. https://doi.org/10.1016/j.tvjl.2018.08.012
Willems, N., Kersten, R. F. M. R., Van Gaalen, S. M., Öner, F. C., Strijkers, G. J., Veraa, S., Beukers, M., Tryfonidou, M. A., & Meij, B. P. (2018). Temporary Segmental Distraction in a Dog with Degenerative Lumbosacral Stenosis. Veterinary and Comparative Orthopaedics and Traumatology, 31(4), 298-303. https://doi.org/10.1055/s-0038-1639599
Tellegen, A. R., Rudnik-Jansen, I., Beukers, M., Miranda-Bedate, A., Bach, F. C., de Jong, W., Woike, N., Mihov, G., Thies, J., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2018). Intradiscal delivery of celecoxib-loaded microspheres restores intervertebral disc integrity in a preclinical canine model. Journal of Controlled Release, 286, 439-450. https://doi.org/10.1016/j.jconrel.2018.08.019
Olthof, M. G. L., Lu, L., Tryfonidou, M. A., Loozen, L., Pouran, B., Yaszemski, M. J., Meij, B., Dhert, W., Alblas, J., & Kempen, D. H. R. (2019). The osteoinductive effect of controlled BMP-2 release is location-dependent. Tissue Engineering. Part A, 25(3-4), 193-202. https://doi.org/10.1089/ten.TEA.2017.0427
de Vries, S. A. H., van Doeselaar, M., Meij, B. P., Tryfonidou, M. A., & Ito, K. (2018). Notochordal cell matrix: An inhibitor of neurite and blood vessel growth? Journal of Orthopaedic Research, 36(12), 3188-3195. https://doi.org/10.1002/jor.24114
Gorissen, B., de Bruin, A., Miranda-Bedate, A., Korthagen, N., Wolschrijn, C., de Vries, T. J., van Weeren, R., & Tryfonidou, M. A. (2019). Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis. Journal of Cellular Physiology, 234, 414-426. https://doi.org/10.1002/jcp.26511
Tellegen, A. R., Rudnik-Jansen, I., Pouran, B., Visser, M. H., Weinans, H., Thomas, R. E., Kik, M. J. L., Grinwis, G. C. M., Thies, J. C., Woike, N., Mihov, G., Emans, P. J., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2018). Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis. Current Drug Delivery, 25(1), 1438-1447. https://doi.org/10.1080/10717544.2018.1482971
Bach, F. C., Tellegen, A. R., Beukers, M., Miranda-Bedate, A., Teunissen, M., de Jong, W. A. M., de Vries, S. A. H., Creemers, L. B., Benz, K., Meij, B. P., Ito, K., & Tryfonidou, M. A. (2018). Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside. Oncotarget, 9(41), 26507-26526. https://doi.org/10.18632/oncotarget.25476
Krouwels, A., Melchels, F. P. W., van Rijen, M. H. P., Öner, F. C., Dhert, W. J. A., Tryfonidou, M. A., & Creemers, L. B. (2018). Comparing Hydrogels for Human Nucleus Pulposus Regeneration: Role of Osmolarity during Expansion. Tissue Engineering - Part C: Methods, 24(4). https://doi.org/10.1089/ten.tec.2017.0226
Olthof, M. G. L., Tryfonidou, M. A., Dadsetan, M., Dhert, W., Yaszemski, M. J., Kempen, D. H. R., & Lu, L. (2018). In Vitro and In Vivo Correlation of BMP-2 Release Profiles from Complex Delivery Vehicles. Tissue engineering. Part C, Methods, 24(7), 379-390. https://doi.org/10.1089/ten.TEC.2018.0024
Steen-Louws, C., Popov-Celeketic, J., Mastbergen, S. C., Coeleveld, K., Hack, C. E., Eijkelkamp, N., Tryfonidou, M., Spruijt, S., van Roon, J. A. G., & Lafeber, F. P. J. G. (2018). IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis. Osteoarthritis and Cartilage, 26(8), 1127-1135. https://doi.org/10.1016/j.joca.2018.05.005
Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M., Tryfonidou, M. A., Yaszemski, M. J., Dhert, W. J. A., & Lu, L. (2018). Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel. Journal of Tissue Engineering and Regenerative Medicine, 12(6), 1339-1351. https://doi.org/10.1002/term.2664
Krouwels, A., Melchels, F. P. W., van Rijen, M. H. P., Ten Brink, C. B. M., Dhert, W. J. A., Cumhur Öner, F., Tryfonidou, M. A., & Creemers, L. B. (2018). Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen- but not carbohydrate-based hydrogels. Acta Biomaterialia, 66, 238-247. https://doi.org/10.1016/j.actbio.2017.11.029
Olthof, M. G. L., Tryfonidou, M., Liu, X., Pouran, B., Meij, B., Dhert, W., Yaszemski, M. J., Lu, L., Alblas, J., & Kempen, D. H. R. (2018). Phosphate functional groups improve OPF osteoconduction and BMP-2 osteoinductive efficacy. Tissue Engineering - Part A.. https://doi.org/10.1089/ten.TEA.2017.0229
2017
Wetenschappelijke publicaties
Jansen, I., Tellegen, A., Plomp, S., Berard, J., Emans, P., De Gendt, E., Thomas, R., De Visser, H., Kik, M., Grinwis, G., Mihov, G., Thies, J., Woike, N., Messier, K., Meij, B., Tryfonidou, M., Creemers, L., I., J., A., T., ... L., C. (2017). Local delivery of triamcinolone acetonide in an aclt model of osteoarthritis impairs joint regeneration, possibly by inhibition of wound healing. In Journal of Orthopaedic Research (Journal of Orthopaedic Research; Vol. 35). John Wiley and Sons Inc.. http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L616813851
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed18&NEWS=N&AN=616813851
Bach, F., Libregts, S., Creemers, L. B., Meij, B., Ito, K., Wauben, M., & Tryfonidou, M. (2017). Notochordal-cell derived extracellular vesicles exert regenerative effects on canine and human nucleus pulposus cells. Oncotarget, 8(51), 88845-88856. https://doi.org/10.18632/oncotarget.21483
Bach, F. C., Laagland, L. T., Grant, M. P., Creemers, L. B., Ito, K., Meij, B. P., Mwale, F., & Tryfonidou, M. A. (2017). Link-N: The missing link towards intervertebral disc repair is species-specific. PLoS One, 12(11), [e0187831]. https://doi.org/10.1371/journal.pone.0187831
Hansen, T., Smolders, L. A., Tryfonidou, M. A., Meij, B. P., Vernooij, J. C. M., Bergknut, N., & Grinwis, G. C. M. (2017). The Myth of Fibroid Degeneration in the Canine Intervertebral Disc: A Histopathological Comparison of Intervertebral Disc Degeneration in Chondrodystrophic and Nonchondrodystrophic Dogs. Veterinary Pathology, 54(6), 945-952. https://doi.org/10.1177/0300985817726834
Teunissen, M., M Riemers, F., van Leenen, D., J A Groot Koerkamp, M., P Meij, B., Alblas, J., C Penning, L., Miranda-Bedate, A., & A Tryfonidou, M. (2018). Growth Plate Expression profiling: Large and Small Breed Dogs Provide New Insights in Endochondral Bone Formation. Journal of Orthopaedic Research. https://doi.org/10.1002/jor.23647
Tellegen, A. R., Willems, N., Beukers, M., Grinwis, G. C. M., Plomp, S. G. M., Bos, C., van Dijk, M., de Leeuw, M., Creemers, L. B., Tryfonidou, M. A., & Meij, B. P. (2018). Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: what's in it for humans? Journal of Tissue Engineering and Regenerative Medicine. https://doi.org/10.1002/term.2483
Teunissen, M., van der Veen, A. J., Smit, T. H., Tryfonidou, M. A., & Meij, B. P. (2017). Effect of a titanium cage as a stand-alone device on biomechanical stability in the lumbosacral spine of canine cadavers. Veterinary Journal, 220, 17-23. https://doi.org/10.1016/j.tvjl.2016.12.007
Bach, F., Miranda-Bedate, A., van Heel, F., Riemers, F., Muller, M., Creemers, L., Ito, K., Benz, K., Meij, B., & Tryfonidou, M. (2017). Bone morphogenetic protein-2, but not mesenchymal stromal cells, exert regenerative effects on canine and human nucleus pulposus cells. Tissue Engineering. Part A, 23(5-6), 233-242. https://doi.org/10.1089/ten.TEA.2016.0251
Willems, N., Mihov, G., Grinwis, G. C. M., van Dijk, M., Schumann, D., Bos, C., Strijkers, G. J., Dhert, W. J. A., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2017). Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 105(4), 707-714. https://doi.org/10.1002/jbm.b.33579
Overige resultaten
Tellegen, A. R., Jansen, I., Thomas, R. E., Visser, H., Kik, M. J. L., Grinwis, G. C. M., Woike, N., Mihov, G., Emans, P. J., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2017). Controlled release of celecoxib from polyesteramide microparticles in a rat model of osteoarthritis. Journal of Orthopaedic Research. Conference, 35(S1), [SP062]. http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emex&AN=616813651 http://sfx.metabib.ch/sfx_locater?sid=OVID:embase&id=pmid:&id=doi:&issn=1554-527X&isbn=&volume=35&issue=&spage=&pages=&date=2017&title=Journal+of+Orthopaedic+Research&a
2016
Wetenschappelijke publicaties
van Rijn, S., Galac, S., Tryfonidou, M. A., Hesselink, J. W., Penning, L. C., Kooistra, H. S., & Meij, B. P. (2016). The Influence of Pituitary Size on Outcome After Transsphenoidal Hypophysectomy in a Large Cohort of Dogs with Pituitary-Dependent Hypercortisolism. Journal of Veterinary Internal Medicine, 30(4), 989-995. https://doi.org/10.1111/jvim.14367
Sbiera, S., Tryfonidou, M. A., Weigand, I., Grinwis, G. C. M., Broeckx, B., Herterich, S., Allolio, B., Deutschbein, T., Fassnacht, M., & Meij, B. P. (2016). Lack of Ubiquitin Specific Protease 8 (USP8) Mutations in Canine Corticotroph Pituitary Adenomas. PLoS One, 11(12), [e0169009]. https://doi.org/10.1371/journal.pone.0169009
Bach, F. C., de Vries, S. A., Riemers, F. M., Boere, J., van Heel, F. W., van Doeselaar, M., Goerdaya, S. S., Nikkels, P. G., Benz, K., Creemers, L. B., Maarten Altelaar, A. F., Meij, B. P., Ito, K., & Tryfonidou, M. A. (2016). Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration. European Cells & Materials [E], 32, 163-80. https://doi.org/10.22203/eCM.v0 32 a11
Bach, F. C., Zhang, Y., Miranda-Bedate, A., Verdonschot, L. C., Bergknut, N., Creemers, L. B., Ito, K., Sakai, D., Chan, D., Meij, B. P., & Tryfonidou, M. A. (2016). Increased caveolin-1 in intervertebral disc degeneration facilitates repair. Arthritis Research & Therapy, 18(59). https://doi.org/10.1186/s13075-016-0960-y
Willems, N., Tellegen, A. R., Bergknut, N., Creemers, L. B., Wolfswinkel, J., Freudigmann, C., Benz, K., Grinwis, G. C. M., Tryfonidou, M. A., & Meij, B. P. (2016). Inflammatory profiles in canine intervertebral disc degeneration. BMC Veterinary Research, 12(10). https://doi.org/10.1186/s12917-016-0635-6
Malagola, E., Teunissen, M., van der Laan, L. J. W., Verstegen, M., Schotanus, B. A., van Steenbeek, F. G., Penning, L. C., van Wolferen, M. E., Tryfonidou, M. A., & Spee, B. (2016). Characterization and comparison of canine multipotent stromal cells derived from liver and bone marrow. Stem Cells and Development, 35(2). https://doi.org/10.1089/scd.2015.0125
Overige resultaten
Tellegen, A., Beukers, M., Miranda-Bedate, A., Willems, N., De Leeuw, M., Van Dijk, M., Creemers, L., Tryfonidou, M., & Meij, B. (2016). Intradiscal Injection of a Slow Release Formulation of Celecoxib for the Treatment of Dogs with Low Back Pain. https://doi.org/10.1016/j.joca.2016.01.879
de Visser, H. M., Mastbergen, S. C., Plomp, S. G., Riemers, F. M., Korthagen, N. M., Tryfonidou, M. A., Lafeber, F. P., & Weinans, H. (2016). A novel method of RNA isolation and gene expression profiling of articular cartilage in rats by cryotome sectioning. S158-S159. https://doi.org/10.1016/j.joca.2016.01.313
2015
Wetenschappelijke publicaties
van den Brom, W. E., Oosterlaken-Dijksterhuis, M. A., Tryfonidou, M. A., Mol, J. A., Hazewinkel, H. A. W., & van den Ingh, T. S. G. A. M. (2015). 24-Hydroxylase: potential key regulator in hypervitaminosis D 3 in growing dogs. American Journal of Physiology-Endocrinology and Metabolism, 284(3), E505-E513. https://doi.org/10.1152/ajpendo.00236.2002
de Vries, S. A. H., Potier, E., van Doeselaar, M., Meij, B. P., Tryfonidou, M. A., & Ito, K. (2015). Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells. Tissue Engineering. Part A, 21(5-6), 1077-1084. https://doi.org/10.1089/ten.TEA.2014.0309
Schutgens, E. M., Tryfonidou, M. A., Öner, F. C., Krouwels, A., Ito, K., & Creemers, L. B. (2015). Biomaterials for intervertebral disc regeneration: past performance and possible future strategies. European Cells & Materials [E], 30, 210-231. https://doi.org/10.22203/eCM.v030a15
van Weeren, P. R., & Tryfonidou, M. A. (2015). Musculoskeletal health from the “One Medicine” perspective – what can we learn rom large and small animal models (with emphasis on articular cartilage)? In BMC Musculoskeletal Disorders (Suppl. 1 ed., Vol. 16, pp. 56). BMC.
https://dspace.library.uu.nl/bitstream/handle/1874/354831/Surrey2015_BMCMusculoskeletalDisorders_.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/354831/Surrey2015_BMCMusculoskeletalDisorders_.pdf?sequence=1
Corbee, R. J., Tryfonidou, M. A., Grinwis, G. C. M., Wolschrijn, C. F., Lau, S. F., Gorissen, B., Heuven, H. C. M., Vaandrager, A. B., & Hazewinkel, H. A. W. (2015). Dietary Vitamin D Supplementation during Early Growth is not Protective for Medial Coronoid Disease Development in Labradors. Journal of veterinary medicine and research, 2(4), 1-8. [1030].
https://dspace.library.uu.nl/bitstream/handle/1874/327223/veterinarymedicine.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/327223/veterinarymedicine.pdf?sequence=1
Tellegen, A. R., Willems, N., Tryfonidou, M. A., & Meij, B. P. (2015). Pedicle screw-rod fixation: a feasible treatment for dogs with severe degenerative lumbosacral stenosis. BMC Veterinary Research, 11(1), [299]. https://doi.org/10.1186/s12917-015-0614-3
Bach, F. C., de Vries, S. A., Krouwels, A., Creemers, L. B., Ito, K., Meij, B. P., & Tryfonidou, M. A. (2015). The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs. European Cells & Materials [E], 30, 132-147.
https://dspace.library.uu.nl/bitstream/handle/1874/327195/NCCM_species.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/327195/NCCM_species.pdf?sequence=1
de Vries, S., Doeselaar, M. V., Meij, B., Tryfonidou, M., & Ito, K. (2015). The Stimulatory Effect of Notochordal-Cell Conditioned Medium in a Nucleus Pulposus Explant Culture. Tissue Engineering. Part A, 22(1-2), 103-110. https://doi.org/10.1089/ten.TEA.2015.0121
Willems, N., Yang, H-Y., Langelaan, M. L. P., Tellegen, A. R., Grinwis, G. C. M., Kranenburg, H-J. C., Riemers, F. M., Plomp, S. G. M., Craenmehr, E. G. M., Dhert, W. J. A., Papen-Botterhuis, N. E., Meij, B. P., Creemers, L. B., & Tryfonidou, M. (2015). Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model. Arthritis Research & Therapy, 17(1), 214. https://doi.org/10.1186/s13075-015-0727-x
van Rijn, S. J., Hanson, J. M., Zierikzee, D., Kooistra, H. S., Penning, L. C., Tryfonidou, M. A., & Meij, B. P. (2015). The Prognostic Value of Perioperative Profiles of ACTH and Cortisol for Recurrence after Transsphenoidal Hypophysectomy in Dogs with Corticotroph Adenomas. Journal of Veterinary Internal Medicine, 29(3), 869-876. https://doi.org/10.1111/jvim.12601
Yang, H-Y., van Ee, R. J., Timmer, K., Craenmehr, E. G. M., Huang, J. H., Öner, F. C., Dhert, W. J. A., Kragten, A. H. M., Willems, N., Grinwis, G. C. M., Tryfonidou, M. A., Papen-Botterhuis, N. E., & Creemers, L. B. (2015). A novel injectable thermoresponsive and cytocompatible gel of poly(N-isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D culture. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2015.05.018
Willems, N., Bach, F. C., Plomp, S. G. M., van Rijen, M. H., Wolfswinkel, J., Grinwis, G. C., Bos, C., Strijkers, G. J., Dhert, W. J., Meij, B. P., Creemers, L. B., & Tryfonidou, M. A. (2015). Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration. Arthritis Research & Therapy, 17, 1-14. [137]. https://doi.org/10.1186/s13075-015-0625-2
Antoniou, J., Wang, H. T., Hadjab, I., Aldebeyan, S., Alaqeel, M. A., Meij, B. P., Tryfonidou, M. A., & Mwale, F. (2015). The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells. Tissue Engineering. Part A, 21(13-14), 2136-2146. https://doi.org/10.1089/ten.TEA.2014.0668
van Rijn, S. J., Pouwer, M. G., Tryfonidou, M. A., Grinwis, G. C. M., van der Bend, J. E. E., Beukers, P. E. P. F., Vastenhout, N., Drouin, J., Penning, L. C., & Meij, B. P. (2015). Expression and clinical relevance of paired box protein 7 and sex determining region Y-box 2 in canine corticotroph pituitary adenomas. Veterinary Journal, 204(3), 315-321. https://doi.org/10.1016/j.tvjl.2015.04.014
Arkesteijn, I. T., Smolders, L. A., Spillekom, S., Riemers, F. M., Potier, E., Meij, B. P., Ito, K., & Tryfonidou, M. A. (2015). Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration. Arthritis Research & Therapy, 17(1), [60]. https://doi.org/10.1186/s13075-015-0569-6
van Dongen, A. M., Heuving, S. M., Tryfonidou, M. A., van Steenbeek, F. G., Rothuizen, J., & Penning, L. C. (2015). Increased bone morphogenetic protein 7 signalling in the kidneys of dogs affected with a congenital portosystemic shunt. Veterinary Journal, 204(2), 226-228. https://doi.org/10.1016/j.tvjl.2015.03.008
2014
Wetenschappelijke publicaties
de Vries, S., Potier, E., Doeselaar, M., Meij, B., Tryfonidou, M., & Ito, K. (2014). Stimulation of Canine Nucleus Pulposus Cells and Bone Marrow-Derived Stromal Cells with Notochordal Cell-Secreted Factors. In Global Spine Journal (pp. po.089). (Global Spine Journal; Vol. 04). https://doi.org/10.1055/s-0034-1376663
Tryfonidou, M. A., Schumann, S., Armeanu, S., Harichandan, A., Sivasubramaniyan, K., Mollenhauer, J., & Bühring, H-J. (2014). Update on canine MSC markers. Cytometry. Part A, 85(5), 379-81. https://doi.org/10.1002/cyto.a.22469
Bach, F. C., Rutten, K., Hendriks, K., Riemers, F. M., Cornelissen, P., de Bruin, A., Arkesteijn, G. J., Wubbolts, R., Horton, W. A., Penning, L. C., & Tryfonidou, M. A. (2014). The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes. Journal of Cellular Physiology, 229(12), 1999-2014. https://doi.org/10.1002/jcp.24658
Lavrijsen, I., Leegwater, P., Martin, AJ., Harris, SJ., Tryfonidou, M., Heuven, H., & Hazewinkel, H. (2014). Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador Retrievers. PLoS One, 9(1), [e87735]. https://doi.org/10.1371/journal.pone.0087735
Corbee, R. J., Tryfonidou, M. A., Grinwis, G. C. M., Schotanus, B., Molenaar, M. R., Voorhout, G., Vaandrager, A. B., Heuven, H. C. M., & Hazewinkel, H. A. W. (2014). Skeletal and hepatic changes induced by chronic vitamin A supplementation in cats. Veterinary Journal, 202(3), 503–509. https://doi.org/10.1016/j.tvjl.2014.09.029
Bach, F. C., Willems, N., Penning, L. C., Ito, K., Meij, B. P., & Tryfonidou, M. A. (2014). Potential regenerative treatment strategies for intervertebral disc degeneration in dogs. BMC Veterinary Research, 10, [10:3 ]. https://doi.org/10.1186/1746-6148-10-3
2013
Wetenschappelijke publicaties
Spillekom, S., Smolders, L. A., Grinwis, G. C. M., Arkesteijn, I., Ito, K., Meij, B. P., & Tryfonidou, M. A. (2013). INCREASED OSMOLARITY AND CELL CLUSTERING PRESERVES CANINE NOTOCHORDAL CELL PHENOTYPE IN CULTURE. Tissue engineering. Part C, Methods, 10.1089/ten.TEC.2013.0479.. https://doi.org/10.1089/ten.TEC.2013.0479
Kranenburg, H. C., Ito, K., Tryfonidou, M. A., Smolders, L. A., Bergknut, N., Oner, F. C., Hazewinkel, H. A. W., Dhert, W. J. A., & Meij, B. P. (2013). Animal Models for Disc Degeneration. In A. D. Sharan, S. Y. Tang, & A. R. Vaccaro (Eds.), Basis Science of Spinal Diseases (pp. 44-51). (2013). Jaypee Brothers Medical Publishers.
Lau, S. F., Hazewinkel, H. A. W., Grinwis, G. C. M., Wolschrijn, C. F., Siebelt, M., Vernooij, J. C. M., Voorhout, G., & Tryfonidou, M. A. (2013). Delayed endochondral ossification in early medial coronoid disease (MCD): A morphological and immunohistochemical evaluation in growing Labrador retrievers. Veterinary Journal, 197(3), 731-738. https://doi.org/10.1016/j.tvjl.2013.04.021
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Houweling, M., Groot Koerkamp, M. J. A., van Leenen, D., Holstege, F. C. P., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2013). Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies. Arthritis Research & Therapy, 15(1), R23. https://doi.org/10.1186/ar4157
Bergknut, N., Smolders, L. A., Grinwis, G. C. M., Hagman, R., Lagerstedt, A. S., Hazewinkel, H. A. W., Tryfonidou, M. A., & Meij, B. P. (2013). Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration. Veterinary Journal, 195(3), 282-291. https://doi.org/10.1016/j.tvjl.2012.10.024
Smolders, L. A., Bergknut, N., Grinwis, G. C. M., Hagman, R., Lagerstedt, A. S., Hazewinkel, H. A. W., Tryfonidou, M. A., & Meij, B. P. (2013). Intervertebral disc degeneration in the dog. Part 2: Chondrodystrophic and non-chondrodystrophic breeds. Veterinary Journal, 195, 292-299. https://doi.org/10.1016/j.tvjl.2012.10.011.
van Rijn, S. J., Tryfonidou, M. A., Hanson, J. M., Penning, L. C., & Meij, B. P. (2013). Stem cells in the canine pituitary gland and in pituitary adenomas. Veterinary Quarterly, 33(4), 217-224. https://doi.org/10.1080/01652176.2013.873961
Populariserende publicaties
Kessel, A. V., Vanderschuren, L. J. M. J., & Tryfonidou, M. (2013). Hond met hernia. Eos, 20-24.
https://dspace.library.uu.nl/bitstream/handle/1874/303084/Hond_met_hernia_eos.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/303084/Hond_met_hernia_eos.pdf?sequence=1
2012
Wetenschappelijke publicaties
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Identification of a novel biomolecular target for regeneration of the degenerated canine intervertebral disc. In Proceedings 25th annual symposium of the European Society of Veterinary Neurology (ECVN) and European College of Veterinary Neurology (ESVN) (pp. 14-14)
Kraus, M. W., Theyse, L. F. H., Tryfonidou, M. A., Hazewinkel, H. A. W., & Meij, B. P. (2012). Treatment of spinal fractures using Lubra plates. A retrospective clinical and radiological evaluation of 15 cases. Veterinary and Comparative Orthopaedics and Traumatology, 25(4), 326-331. https://doi.org/10.3415/VCOT-11-07-0096
Smolders, L. A., Onis, D., Riemers, F. M., Penning, L. C., Bergknut, N., Kranenburg, H. C., Hazewinkel, H. A. W., Grinwis, G. C. M., Groot Koerkamp, M., Meij, B. P., & Tryfonidou, M. A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration. In Abstract Book Spineweek 2012 (pp. 256)
Willems, N., Tryfonidou, M. A., Meij, B. P., Hazewinkel, H. A. W., Creemers, L. B., Licht, R., Dhert, W. J. A., Schuman, D., van Dijk, M., de Leeuw, M., Piest, M., Papen-Boterhuis, N. E., & Langelaan, M. (2012). Injection of (un)loaded hydrogels and microspheres in intervertebral discs of laboratory beagle dogs. In Proceedings BMM / TERM Annual Meeting (pp. 17-17)
Tryfonidou, M. A. (2012). Gene Expression Profiling of early intervertebral disc degeneration. In World Forum for Spine Research 2012 : Global Spine Journal (pp. 17-18)
https://dspace.library.uu.nl/bitstream/handle/1874/275681/Poster%2520AO%2520Spine%25202012.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/275681/Poster%2520AO%2520Spine%25202012.pdf?sequence=1
Corbee, R. J., Tryfonidou, M. A., Beckers, I., & Hazewinkel, H. A. W. (2012). Composition and use of puppy milk replacers in German Shepherd puppies in the Netherlands. Journal of Animal Physiology and Animal Nutrition, 96(3), 395-402. https://doi.org/10.1111/j.1439-0396.2011.01153.x
Corbee, R. J., Booij-Vrieling, H. E., van de Lest, C. H. A., Penning, L. C., Tryfonidou, M. A., Riemers, F. M., & Hazewinkel, H. A. W. (2012). Inflammation and wound healing in cats with chronic gingivitis/stomatitis after extraction of all premolars and molars were not affected by feeding of two diets with different omega-6/omega-3 polyunsaturated fatty acid ratios. Journal of Animal Physiology and Animal Nutrition, 96(2012), 679-688. https://doi.org/10.1111/j.1439-0396.2011.01195.x
Smolders, L. A., Meij, B. P., Riemers, F. M., Licht, R., Wubbolts, R. W., van den Heuvel, D. J., Grinwis, G. C. M., Vernooij, H., Hazewinkel, H. A. W., Penning, L. C., & Tryfonidou, M. A. (2012). Canonical Wnt Signaling in the Notochordal Cell is Upregulated in Early Intervertebral Disk Degeneration. Journal of Orthopaedic Research, 30(6), 950-957. https://doi.org/10.1002/jor.22000
Smolders, L. A., Meij, B. P., Onis, D., Riemers, F. M., Bergknut, N., Wubbolts, R. W., Grinwis, G. C. M., Groot Koerkamp, M., Holstege, F. C., Hazewinkel, H. A. W., Creemers, L. B., Penning, L. C., & Tryfonidou, M. A. (2012). Gene expression profiling of naturally occurring early intervertebral disc degeneration suggests a crucial role of caveolin-1 in notochordal cell preservation. In Proceedings European Veterinary Conference Voorjaarsdagen 2012 (pp. 236-237)
Corbee, R. J., Tryfonidou, M. A., Meij, B. P., Kooistra, H. S., & Hazewinkel, H. A. W. (2012). Vitamin D status before and after hypophysectomy in dogs with pituitary-dependent hypercortisolism. Domestic Animal Endocrinology, 42, 43-49.
Booij-Vrieling, H. E., de Vries, T. J., Schoenmaker, T., Tryfonidou, M. A., Penning, L. C., Hazewinkel, H. A. W., & Everts, V. (2012). Osteoclast progenitors from cats with and without tooth resorption respond differently to 1,25-dihydroxyvitamin D and interleukin-6. Research in Veterinary Science, 92(2012), 311-316.
2011
Wetenschappelijke publicaties
Tryfonidou, M. A., Lunstrum, G. P., Hendriks, K., Riemers, F. M., Wubbolts, R. W., Hazewinkel, H. A. W., Degnin, C. R., & Horton, W. A. (2011). Novel type II collagen reporter mice: New tool for assessing collagen 2α1 expression in vivo and in vitro. Developmental Dynamics, Mar(240 (3)), 663-673.
2010
Wetenschappelijke publicaties
Vrieling, H. E., Ferbus, D., Tryfonidou, M. A., Riemers, F. M., Penning, L. C., Berdal, A., Everts, V., & Hazewinkel, H. A. W. (2010). Increased vitamin D-driven signalling and expression of the vitamin D receptor, MSX2, and RANKL in tooth resorption in cats. European Journal of Oral Sciences, 118(1), 39-46.
https://dspace.library.uu.nl/bitstream/handle/1874/204556/j.1600-0722.2009.00707.x.pdf?sequence=3
https://dspace.library.uu.nl/bitstream/handle/1874/204556/j.1600-0722.2009.00707.x.pdf?sequence=3
Tryfonidou, M. A., Hazewinkel, H. A. W., Riemers, F. M., Brinkhof, B., Penning, L. C., & Karperien, M. (2010). Intraspecies disparity in growth rate is associated with differences in expression of local growth plate regulators. American Journal of Physiology-Endocrinology and Metabolism, 299(6), 1044-1052. https://doi.org/10.1152/ajpendo.00170.2010
Tryfonidou, M. A., Hazewinkel, H. A. W., & Kooistra, H. S. (2010). Calciotropic hormones. In H. S. Kooistra, & A. Rijnberk (Eds.), Clinical Endocrinology of Dogs and Cats, 2nd ed. (pp. 253-289). (2). Schlütersche.
2009
Wetenschappelijke publicaties
Vrieling, H. E., Tryfonidou, M. A., Riemers, F. M., Penning, L. C., & Hazewinkel, H. A. W. (2009). Inflammatory cytokines and the nuclear vitamin D receptor are implicated in the pathophysiology of dental resorptive lesions in cats. Veterinary Immunology and Immunopathology, 132, 160-166.
Vegter, A. R., Oosterhout, M. F. M., Verhoeven, B. J. P., Tryfonidou, M. A., Boroffka, S. A. E. B., & Stokhof, A. A. (2009). Cardiac changes induced by excess exogenous growth hormone in juvenile miniature poodles. Veterinary Journal, 182, 446-451.
2007
Wetenschappelijke publicaties
Hazewinkel, H. A. W., & Tryfonidou, M. A. (2007). Nutrition in growing animals. In Feline and Canine paediatrics and neonatology (pp. 76-80).
Hazewinkel, H. A. W., & Tryfonidou, M. A. (2007). Developmental orthopaedic diseases in the young animal. In Feline and Canine paediatrics and Neonatology (pp. 81-88)
Hazewinkel, H. A. W., & Tryfonidou, M. A. (2007). Vitamin D3 metabolism in dogs. Molecular and Cellular Endocrinology, 197, 202-233.
Hazewinkel, H. A. W., & Tryfonidou, M. A. (2007). Nutrition of the neonate and the puppy. In Feline and canine paediatrics and neonatology (pp. 27-33)
2006
Wetenschappelijke publicaties
Tryfonidou, M. A., & Klein, W. R. (2006). Electro-,cryo-,laser and endoscopic surgery. Chapter 4. In The cuttong edge; basic operation skills for the veterinary surgeon
2005
Wetenschappelijke publicaties
Tryfonidou, M. A., & Hazewinkel, H. A. W. (2005). Ik groei als kool. In Groei - Najaarsdag Groep Geneeskunde Gezelschapsdieren (pp. 24-29)
Tryfonidou, M. A., & Klein, W. R. (2005). Hoofdstuk 4 : Elektro-, cryo, laser en endoscopische-chirurgie. In J. Kirpensteijn, & W. R. Klein (Eds.), Leren opereren (pp. 45-51). Roman House Publishers.
2004
Wetenschappelijke publicaties
Tryfonidou, M. A., & Hazewinkel, H. A. W. (2004). Different effects of physiologically and pharmacologically increased growth hormone levels on cholecalciferol metabolism at prepubertal age. Journal of Steroid Biochemistry and Molecular Biology, 89-90, 49-54.
2003
Wetenschappelijke publicaties
Tryfonidou, M. A., Oosterlaken-Dijksterhuis, M. A., Mol, J. A., van den Ingh, T. S. G. A. M., van den Brom, W. E., & Hazewinkel, H. A. W. (2003). 24-Hydroxylase: potential key regulator in hypervitaminosis D3 in growing dogs. American Journal of Physiology-Endocrinology and Metabolism, 284, 505-513.
2002
Wetenschappelijke publicaties
Hazewinkel, H. A. W., & Tryfonidou, M. A. (2002). Vitamin D3 metabolism in dogs. Molecular and Cellular Endocrinology, 197, 22-33.
Tryfonidou, M. A., van den Broek, J., van den Brom, W. E., & Hazewinkel, H. A. W. (2002). Intestinal calcium absorption in growing dogs is influenced by calcium intake and age and not by growth rate. Journal of Nutrition, 132, 3363-3368.
Tryfonidou, M. A. (2002). Involvement of vitamin D3 metabolism in calcium homeostasis and skeletal development in growing dogs . Optima.
Tryfonidou, M. A., Stevenhagen, J. J., van den Bemd, G. J. C. M., Oosterlaken-Dijksterhuis, M. A., DeLuca, H. F., Mol, J. A., van den Brom, W. E., van Leeuwen, J. P. T. M., & Hazewinkel, H. A. W. (2002). Moderate cholecalciferol supplementation depresses intestinal calcium absorption in growing dogs. Journal of Nutrition, 132, 2644-2650.
Vakpublicaties
Holl, M. S., Tryfonidou, M. A., Birkenhäger-Frenkel, D. H., & Hazewinkel, H. A. W. (2002). De effecten van langdurige vitamine-D3-toediening via de voeding op botmineralen van jonge honden . Nederlands Tijdschrift voor Osteoporose en Andere Botziekten, 6, 94-94.
Tryfonidou, M. A., Oosterlaken-Dijksterhuis, M. A., Mol, J. A., & Hazewinkel, H. A. W. (2002). Verhoogde productie en verhoogde metabole klaring van 1,25(OH)2D3 bij langdurige vitamine-D3-suppletie. Nederlands Tijdschrift voor Osteoporose en Andere Botziekten, 6, 95-96.
2001
Wetenschappelijke publicaties
Tryfonidou, M. A., van Wees, A., van den Brom, W. E., & Hazewinkel, H. A. W. (2001). Balance studies employing 45Ca. In International Symposium "Comparative Clinical and Molecular Endocrinology". Utrecht. (pp. 25-27)
Hazewinkel, H. A. W., & Tryfonidou, M. A. (2001). Calcium metabolism investigations. In International Symposium "Comparative Clinical and Molecular Endocrinology". (pp. 22-24)
Tryfonidou, M. A., & Hazewinkel, H. A. W. (2001). An up-date of results on calcium metabolic studies in growing Great Danes. In International Large Breed Health Care Symposium, Venice Italy. (pp. 17-221)
Vakpublicaties
Hazewinkel, H. A. W., Tryfonidou, M. A., Mol, J. A., How, K. L., Schoenmakers, I., & Nap, R. C. (2001). De invloed van UV-licht en calcium in de voeding op de plasmaconcentratie van vitamine D3-metabolieten bij de hond. Nederlands Tijdschrift voor Osteoporose en Andere Botziekten, 70-70.