U kunt een volledige lijst vinden via mijn ORCID auteur-id: http://orcid.org/0000-0002-0808-3811
Publicaties
2023
Wetenschappelijke publicaties
Bahri, S., Safeer, A., Adler, A., Smedes, H., van Ingen, H., & Baldus, M. (2023). 1H-detected characterization of carbon-carbon networks in highly flexible protonated biomolecules using MAS NMR. Journal of Biomolecular NMR. https://doi.org/10.1007/s10858-023-00415-6
Adler, A., Kjaer, L. F., Beugelink, J. W., Baldus, M., & van Ingen, H. (2023). Resonance assignments of the microtubule-binding domain of the microtubule-associated protein 7 (MAP7). Biomolecular NMR Assignments. https://doi.org/10.1007/s12104-023-10124-8
Kopacz, N., Corazzi, M. A., Poggiali, G., von Essen, A., Kofman, V., Fornaro, T., van Ingen, H., Camprubi, E., King, H. E., Brucato, J., & ten Kate, I. L. (2023). The photochemical evolution of polycyclic aromatic hydrocarbons and nontronite clay on early Earth and Mars. Icarus, 394, [115437]. https://doi.org/10.1016/j.icarus.2023.115437
2022
Wetenschappelijke publicaties
Corbeski, I., Guo, X., Eckhardt, B. V., Fasci, D., Wiegant, W., Graewert, M. A., Vreeken, K., Wienk, H., Svergun, D. I., Heck, A. J. R., van Attikum, H., Boelens, R., Sixma, T. K., Mattiroli, F., & van Ingen, H. (2022). Chaperoning of the histone octamer by the acidic domain of DNA repair factor APLF. Science advances, 8(30), [eabo0517]. https://doi.org/10.1126/sciadv.abo0517
2021
Wetenschappelijke publicaties
Zhang, H., Eerland, J., Horn, V., Schellevis, R., & van Ingen, H. (2021). Mapping the electrostatic potential of the nucleosome acidic patch. Scientific Reports, 11(1), 1-11. [23013]. https://doi.org/10.1038/s41598-021-02436-3
le Paige, U. B., Xiang, S., Hendrix, M. M. R. M., Zhang, Y., Folkers, G. E., Weingarth, M., Bonvin, A. M. J. J., Kutateladze, T. G., Voets, I. K., Baldus, M., & van Ingen, H. (2021). Characterization of nucleosome sediments for protein interaction studies by solid-state NMR spectroscopy. Magnetic Resonance, 2(1), 187-202. https://doi.org/10.5194/mr-2-187-2021
Henneman, B., Brouwer, T. B., Erkelens, A. M., Kuijntjes, G-J., van Emmerik, C., van der Valk, R. A., Timmer, M., Kirolos, N. C. S., van Ingen, H., van Noort, J., & Dame, R. T. (2021). Mechanical and structural properties of archaeal hypernucleosomes. Nucleic Acids Research, 49(8), 4338–4349. https://doi.org/10.1093/nar/gkaa1196
Lobbia, V. R., Trueba Sanchez, M. C., & van Ingen, H. (2021). Beyond the Nucleosome: Nucleosome-Protein Interactions and Higher Order Chromatin Structure. Journal of Molecular Biology, 433(6), [166827]. https://doi.org/10.1016/j.jmb.2021.166827
2020
Wetenschappelijke publicaties
Le Paige, U. B., & van Ingen, H. (2020). Nucleosome under NMR’s eye – A practical guide. eMagRes, 9(4), 283-292. https://doi.org/10.1002/9780470034590.emrstm1625
Teles, K., Fernandes, V., Silva, I., Leite, M., Grisolia, C., Lobbia, V. R., van Ingen, H., Honorato, R., Lopes-de-Oliveira, P., Treptow, W., & Santos, G. (2020). Corrigendum to “Nucleosome binding peptide presents laudable biophysical and in vivo effects” [Biomed. Pharmacother. 121 (2020) 109678]. Biomedicine and Pharmacotherapy, 123, [109805]. https://doi.org/10.1016/j.biopha.2019.109805
Ben Bdira, F., Waudby, C. A., Volkov, A. N., Schröder, S. P., Ab, E., Codée, J. D. C., Overkleeft, H. S., Aerts, J. M. F. G., van Ingen, H., & Ubbink, M. (2020). Dynamics of Ligand Binding to a Rigid Glycosidase**. Angewandte Chemie-International Edition, 59(46), 20508-20514. https://doi.org/10.1002/anie.202003236
Horn, V., Jongkees, S. A. K., & van Ingen, H. (2020). Mimicking the Nucleosomal Context in Peptide-Based Binders of a H3K36me Reader Increases Binding Affinity While Altering the Binding Mode. Molecules (Basel, Switzerland), 25(21), 1-15. [4951]. https://doi.org/10.3390/molecules25214951
Teles, K., Fernandes, V., Silva, I., Leite, M., Grisolia, C., Lobbia, V. R., van Ingen, H., Honorato, R., Lopes-de-Oliveira, P., Treptow, W., & Santos, G. (2020). Nucleosome binding peptide presents laudable biophysical and in vivo effects. Biomedicine and Pharmacotherapy, 121, [109678]. https://doi.org/10.1016/j.biopha.2019.109678
Elings, W., Gaur, A., Blok, A. J., Timmer, M., van Ingen, H., & Ubbink, M. (2020). β-Lactamase of Mycobacterium tuberculosis shows dynamics in the active site that increase upon inhibitor binding. Antimicrobial Agents and Chemotherapy, 64(3), [e02025-19]. https://doi.org/10.1128/AAC.02025-19
https://dspace.library.uu.nl/bitstream/handle/1874/391257/Antimicrobial_Agents_and_Chemotherapy_2019_Elings_AAC.02025_19.full.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/391257/Antimicrobial_Agents_and_Chemotherapy_2019_Elings_AAC.02025_19.full.pdf?sequence=1
Horn, V., & van Ingen, H. (2020). Recognition of Nucleosomes by Chromatin Factors: Lessons from Data-Driven Docking-Based Structures of Nucleosome-Protein Complexes. In C. Logie, & T. A. Knoch (Eds.), Chromatin and Epigenetics (pp. 21-46). IntechOpen. https://doi.org/10.5772/intechopen.81016
van Emmerik, C. L., Gachulincova, I., Lobbia, V. R., Daniëls, M. A., Heus, H. A., Soufi, A., Nelissen, F. H. T., & van Ingen, H. (2020). Ramified rolling circle amplification for synthesis of nucleosomal DNA sequences. Analytical Biochemistry, 588, [113469]. https://doi.org/10.1016/j.ab.2019.113469
2019
Wetenschappelijke publicaties
Horn, V., Uckelmann, M., Zhang, H., Eerland, J., Aarsman, I., le Paige, U. B., Davidovich, C., Sixma, T. K., & van Ingen, H. (2019). Structural basis of specific H2A K13/K15 ubiquitination by RNF168. Nature Communications, 10(1), [1751]. https://doi.org/10.1038/s41467-019-09756-z
van Emmerik, C. L., & van Ingen, H. (2019). Unspinning chromatin: Revealing the dynamic nucleosome landscape by NMR. Progress in Nuclear Magnetic Resonance Spectroscopy, 110, 1-19. https://doi.org/10.1016/j.pnmrs.2019.01.002
Goldbach, L., Vermeulen, B. J. A., Caner, S., Liu, M., Tysoe, C., van Gijzel, L., Yoshisada, R., Trellet, M., van Ingen, H., Brayer, G. D., Bonvin, A. M. J. J., & Jongkees, S. A. K. (2019). Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase. ACS Chemical Biology, 14(8), 1751-1759. https://doi.org/10.1021/acschembio.9b00290
Kim, R. Q., Geurink, P. P., Mulder, M. P. C., Fish, A., Ekkebus, R., El Oualid, F., van Dijk, W. J., van Dalen, D., Ovaa, H., van Ingen, H., & Sixma, T. K. (2019). Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity. Nature Communications, 10(1), [231]. https://doi.org/10.1038/s41467-018-08231-5
2018
Wetenschappelijke publicaties
Chatterjee, S. D., Ubbink, M., & van Ingen, H. (2018). Removal of slow-pulsing artifacts in in-phase 15N relaxation dispersion experiments using broadband 1H decoupling. Journal of Biomolecular NMR, 71(2), 69-77. https://doi.org/10.1007/s10858-018-0193-2
Henneman, B., van Emmerik, C., van Ingen, H., & Dame, R. T. (2018). Structure and function of archaeal histones. PLoS Genetics, 14(9), [1007582]. https://doi.org/10.1371/journal.pgen.1007582
Corbeski, I., Horn, V., Van Der Valk, R. A., Le Paige, U. B., Dame, R. T., & Van Ingen, H. (2018). Microscale Thermophoresis Analysis of Chromatin Interactions. In R. T. Dame (Ed.), Bacterial Chromatin: Methods and Protocols (pp. 177-197). (Methods in Molecular Biology; Vol. 1837). Humana Press. https://doi.org/10.1007/978-1-4939-8675-0_11
https://dspace.library.uu.nl/bitstream/handle/1874/372165/Corbeski2018_Protocol_MicroscaleThermophoresisAnalys.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/372165/Corbeski2018_Protocol_MicroscaleThermophoresisAnalys.pdf?sequence=1
Xiang, S., le Paige, U. B., Horn, V., Houben, K., Baldus, M., & van Ingen, H. (2018). Site-Specific Studies of Nucleosome Interactions by Solid-State NMR Spectroscopy. Angewandte Chemie-International Edition, 57(17), 4571-4575. https://doi.org/10.1002/anie.201713158
Fasci, D., van Ingen, H., Scheltema, R. A., & Heck, A. J. R. (2018). Histone interaction landscapes visualized by crosslinking mass spectrometry in intact cell nuclei. Molecular and Cellular Proteomics, 17(10), 2018-2033. https://doi.org/10.1074/mcp.RA118.000924
Corbeski, I., Dolinar, K., Wienk, H., Boelens, R., & van Ingen, H. (2018). DNA repair factor APLF acts as a H2A-H2B histone chaperone through binding its DNA interaction surface. Nucleic Acids Research, 46(14), 7138–7152. https://doi.org/10.1093/nar/gky507
2017
Wetenschappelijke publicaties
Kitevski-Leblanc, J., Fradet-Turcotte, A., Kukic, P., Wilson, M. D., Portella, G., Yuwen, T., Panier, S., Duan, S., Canny, M. D., Van Ingen, H., Arrowsmith, C. H., Rubinstein, J. L., Vendruscolo, M., Durocher, D., & Kay, L. E. (2017). The rnf168 paralog rnf169 defines a new class of ubiquitylated histone reader involved in the response to dna damage. eLife, 6, [e23872]. https://doi.org/10.7554/eLife.23872
le Paige, U. B., Smits, B., t Hart, P., Lefeber, F., Martin, N. I., & van Ingen, H. (2017). Weak coupling between magnetically inequivalent spins: The deceptively simple, complicated spectrum of a 13C-labeled trimethylated amine. Journal of Magnetic Resonance, 278, 96-103. https://doi.org/10.1016/j.jmr.2017.03.016
2016
Wetenschappelijke publicaties
Zhang, H., & van Ingen, H. (2016). Isotope-labeling strategies for solution NMR studies of macromolecular assemblies. Current Opinion in Structural Biology, 38, 75-82. https://doi.org/10.1016/j.sbi.2016.05.008
2014
Wetenschappelijke publicaties
Khan, F., Daniëls, M. A., Folkers, G. E., Boelens, R., Saqlan Naqvi, S. M., & Van Ingen, H. (2014). Structural basis of nucleic acid binding by Nicotiana tabacum glycine-rich RNA-binding protein: Implications for its RNA chaperone function. Nucleic Acids Research, 42(13), 8705-8718. https://doi.org/10.1093/nar/gku468
Van Ingen, H., & Bonvin, A. M. J. J. (2014). Information-driven modeling of large macromolecular assemblies using NMR data. Journal of Magnetic Resonance, 241(1), 103-114. https://doi.org/10.1016/j.jmr.2013.10.021
2013
Wetenschappelijke publicaties
Spruijt, C. G., Gnerlich, F., Smits, A. H., Pfaffeneder, T., Jansen, P. W. T. C., Bauer, C., Munzel, M., Wagner, M., Müller, M., Khan, F., Eberl, H. C., Mensinga, A., Brinkman, A. B., Lephikov, K., Muller, U., Walter, J., Boelens, R., van Ingen, H., Leonhardt, H., & Carell, T. (2013). Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Cell, 152, 1146-1159. https://doi.org/10.1016/j.cell.2013.02.004
van Nuland, R., van Schaik, F. M. A., Simonis, M. J., Cuppen, E. P. J. G., Boelens, R., Timmers, H. T. M., & van Ingen, H. (2013). Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain. Epigenetics & Chromatin [E], 6, 1-12. [12]. https://doi.org/10.1186/1756-8935-6-12
Yu, B., van Ingen, H., & Freedberg, D. I. (2013). Constant time INEPT CT-HSQC (CTi-CT-HSQC) – A new NMR method to measure accurate one-bond J and RDCs with strong 1H–1H couplings in natural abundance. Journal of Magnetic Resonance, 228, 159-166. https://doi.org/10.1016/j.jmr.2012.11.007
2012
Wetenschappelijke publicaties
Yu, B., van Ingen, H., Vivekanandan, S., Rademacher, C., Norris, S. E., & Freedberg, D. I. (2012). More accurate 1JCH coupling measurement in the presence of 3JHH strong coupling in in natural abundance. Journal of Magnetic Resonance, 215, 10-22. https://doi.org/10.1016/j.jmr.2011.09.037
2011
Wetenschappelijke publicaties
Kato, H., Van Ingen, H., Zhou, B-R., Feng, H., Bustin, M., Kay, L. E., & Bai, Y. (2011). Architecture of the high mobility group nucleosomal protein 2-nucleosome complex as revealed by methyl-based NMR. Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12283-12288. https://doi.org/10.1073/pnas.1105848108
2010
Wetenschappelijke publicaties
Brondijk, T. H. C., de Ruiter, T., Ballering, J., Wienk, H., Lebbink, R. J., van Ingen, H., Boelens, R., Farndale, R. W., Meyaard, L., & Huizinga, E. G. (2010). Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI. Blood, 115(7), 1364-1373. https://doi.org/10.1182/blood-2009-10-246322
2009
Wetenschappelijke publicaties
van Ingen, H., Korzhnev, D. M., & Kay, L. E. (2009). An analysis of the effects of 1HN-(1)HN dipolar couplings on the measurement of amide bond vector orientations in invisible protein states by relaxation dispersion NMR. Journal of Physical Chemistry B, 113(29), 9968-9977. https://doi.org/10.1021/jp902793y
van Ingen, H., van Schaik, F. M. A., Wienk, H., Rehmann, H., Kruijtzer, J. A. W., Liskamp, R. M. J., Timmers, H. T. M., & Boelens, R. (2009). Recognition of trimethylated K4 of histone H3 by the TFIID subunit TAF3. Journal of Biomolecular Structure and Dynamics, 26, 909.
2008
Wetenschappelijke publicaties
van Ingen, H., van Schaik, F. M. A., Wienk, H., Ballering, J., Rehmann, H., Dechesne, A. C., Kruijzer, J. A. W., Liskamp, R. M. J., Timmers, H. T. M., & Boelens, R. (2008). Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. Structure, 16(8), 1245-1256.
https://dspace.library.uu.nl/bitstream/handle/1874/32066/539.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/32066/539.pdf?sequence=1
Codutti, L., van Ingen, H., Vascotto, C., Fogolari, F., Corazza, A., Tell, G., Quadrifoglio, F., Viglino, P., Boelens, R., & Esposito, G. (2008). The solution structure of DNA-free Pax-8 paired box domain accounts for redox regulation of transcriptional activity in the Pax protein family. Journal of Biological Chemistry, 283(48), 33321-33328.
https://dspace.library.uu.nl/bitstream/handle/1874/33240/545.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/33240/545.pdf?sequence=1
2006
Wetenschappelijke publicaties
van Ingen, H., Baltussen, M. A. H., Aelen, J., & Vuister, G. W. (2006). Role of Structural and Dynamical Plasticity in Sin3: The Free PAH2 Domain is a Folded Module in mSin3B. Journal of Molecular Biology, 358(2), 485-497. https://doi.org/10.1016/j.jmb.2006.01.100
Van Ingen, H., Vuister, G. W., Wijmenga, S., & Tessari, M. (2006). CEESY: Characterizing the conformation of unobservable protein states. Journal of the American Chemical Society, 128(12), 3856-3857. https://doi.org/10.1021/ja0568749
2004
Wetenschappelijke publicaties
Van Ingen, H., Lasonder, E., Jansen, J. F. A., Kaan, A. M., Spronk, C. A. E. M., Stunnenberg, H. G., & Vuister, G. W. (2004). Extension of the Binding Motif of the Sin3 Interacting Domain of the Mad Family Proteins. Biochemistry, 43(1), 46-54. http://www.nmr.chem.uu.nl/~hugo/files/publications/HvI_Biochem_2004.pdf
2003
Wetenschappelijke publicaties
Wingens, M., Walma, T., Van Ingen, H., Stortelers, C., Van Leeuwen, J. E. M., Van Zoelen, E. J. J., & Vuister, G. W. (2003). Structural analysis of an epidermal growth factor/transforming growth factor-α chimera with unique ErbB binding specificity. Journal of Biological Chemistry, 278(40), 39114-39123. https://doi.org/10.1074/jbc.M305603200
2002
Wetenschappelijke publicaties
van Ingen, H., Vuister, G. W., & Tessari, M. (2002). A two-dimensional artifact from asynchronous decoupling. Journal of Magnetic Resonance, 156(2), 258-61. https://doi.org/10.1006/jmre.2002.2564
van Ingen, H., Tessari, M., & Vuister, G. W. (2002). A 3D doubly sensitivity enhanced X-filtered TOCSY-TOCSY experiment. Journal of Biomolecular NMR, 24(2), 155-160. https://doi.org/10.1023/A:1020975705237