Publications  

INTERNATIONAL PEER REVIEWED JOURNALS

Scopus h-index :  72 based on 222 publications)

Citations:16032 total citations (August 2023)

Recent

The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design.Ruijter N, Soeteman-Hernández LG, Carrière M, Boyles M, McLean P, Catalán J, Katsumiti A, Cabellos J, Delpivo C, Sánchez Jiménez A, Candalija A, Rodríguez-Llopis I, Vázquez-Campos S, Cassee FR, Braakhuis H.Nanomaterials (Basel). 2023 Jan 24;13(3):472. doi: 10.3390/nano13030472.

Neuromodulatory and neurotoxic effects of e-cigarette vapor using a realistic exposure method.Staal YCM, Li Y, Gerber LS, Fokkens P, Cremers H, Cassee FR, Talhout R, Westerink RHS, Heusinkveld HJ.Inhal Toxicol. 2023 Mar-Apr;35(3-4):76-85. doi: 10.1080/08958378.2022.2118911.

In vitro neurotoxicity screening of engine oil- and hydraulic fluid-derived aircraft cabin bleed-air contamination.Gerber LS, van Kleef RGDM, Fokkens P, Cassee FR, Westerink RH.Neurotoxicology. 2023 May;96:184-196. doi: 10.1016/j.neuro.2023.04.010.

Placental-fetal distribution of carbon particles in a pregnant rabbit model after repeated exposure to diluted diesel engine exhaust.Bongaerts E, Nawrot TS, Wang C, Ameloot M, Bové H, Roeffaers MB, Chavatte-Palmer P, Couturier-Tarrade A, Cassee FR.Part Fibre Toxicol. 2023 May 18;20(1):20. doi: 10.1186/s12989-023-00531-z.

Establishing relationships between particle-induced in vitro and in vivo inflammation endpoints to better extrapolate between in vitro markers and in vivo fibrosis.McLean P, Mueller W, Gosens I, Cassee FR, Rothen-Rutishauser B, Boyles M, Tran L.Part Fibre Toxicol. 2023 Feb 9;20(1):5. doi: 10.1186/s12989-023-00516-y.

2022

·         Bannuscher A, Schmid O, Drasler B, Rohrbasser A, Braakhuis HM, Meldrum K, Zwart EP, Gremmer ER, Birk B, Rissel M, Landsiedel R, Moschini E, Evans SJ, Kumar P, Orak S, Doryab A, Erdem JS, Serchi T, Vandebriel RJ, Cassee FR, Doak SH, Petri-Fink A, Zienolddiny S, Clift MJD, Rothen-Rutishauser B. An inter-laboratory effort to harmonize the cell-delivered in vitro dose of aerosolized materials. NanoImpact. 2022 Oct;28:100439. 

·         Bessa MJ, Brandão F, Fokkens PHB, Leseman DLAC, Boere AJF, Cassee FR, Salmatonidis A, Viana M, Monfort E, Fraga S, Teixeira JP. Unveiling the Toxicity of Fine and Nano-Sized Airborne Particles Generated from Industrial Thermal Spraying Processes in Human Alveolar Epithelial Cells. Int J Mol Sci. 2022 Apr 13;23(8):4278. doi: 10.3390/ijms23084278.

·         Doak SH, Clift MJD, Costa A, Delmaar C, Gosens I, Halappanavar S, Kelly S, Pejinenburg WJGM, Rothen-Rutishauser B, Schins RPF, Stone V, Tran L, Vijver MG, Vogel U, Wohlleben W, Cassee FR. The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies. Small. 2022 Apr;18(17):e2200231. doi: 10.1002/smll.202200231. Epub 2022 Mar 24.

·         Doak SH, Clift MJD, Costa A, Delmaar C, Gosens I, Halappanavar S, Kelly S, Pejinenburg WJGM, Rothen-Rutishauser B, Schins RPF, Stone V, Tran L, Vijver MG, Vogel U, Wohlleben W, Cassee FR. The Road to Achieving the European Commission's Chemicals Strategy for Nanomaterial Sustainability-A PATROLS Perspective on New Approach Methodologies. Small. 2022 Apr;18(17):e2200231.

·         Skuland T, Grytting VS, Låg M, Jørgensen RB, Snilsberg B, Leseman DLAC, Kubátová A, Emond J, Cassee FR, Holme JA, Øvrevik J, Refsnes M. Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells. Part Fibre Toxicol. 2022 Jul 4;19(1):45.

·         Skuland T, Grytting VS, Låg M, Jørgensen RB, Snilsberg B, Leseman DLAC, Kubátová A, Emond J, Cassee FR, Holme JA, Øvrevik J, Refsnes M. Road tunnel-derived coarse, fine and ultrafine particulate matter: physical and chemical characterization and pro-inflammatory responses in human bronchial epithelial cells. Part Fibre Toxicol. 2022 Jul 4;19(1):45. doi: 10.1186/s12989-022-00488-5.

·         Staal YCM, Li Y, Gerber LS, Fokkens P, Cremers H, Cassee FR, Talhout R, Westerink RHS, Heusinkveld HJ. Neuromodulatory and neurotoxic effects of e-cigarette vapor using a realistic exposure method. Inhal Toxicol. 2022 Sep 2:1-10.  

·         Torkmahalleh A. M, Naseri M, Nurzhan S, Gabdrashova R, Bekezhankyzy Z, Gimnkhan A, Malekipirbazari M, Jouzizadeh M, Tabesh M, Farrokhi H, Mehri-Dehnavi H, Khanbabaie R, Sadeghi S, Khatir AA, Sabanov S, Buonanno G, Hopke PK, Cassee F, Crape B. Human exposure to aerosol from indoor gas stove cooking and the resulting nervous system responses. Indoor Air. 2022 Feb;32(2):e12983.

·         Waaijers-van der Loop S, van Bruggen A, Beijer NRM, Sips A, de Roda Husman AM, Cassee F, Peijnenburg W. Improved science-based transformation pathways for the development of safe and sustainable plastics. Environ Int. 2022 Feb;160:107055. 

·         Waaijers-van der Loop S, van Bruggen A, Beijer NRM, Sips A, de Roda Husman AM, Cassee F, Peijnenburg W. Improved science-based transformation pathways for the development of safe and sustainable plastics. Environ Int. 2022 Feb;160:107055. doi: 10.1016/j.envint.2021.107055. Epub 2022 Jan 5.

·         Gosens Ilse , Pedro M Costa, Magnus Olsson, Vicki Stone, Anna L Costa, Andrea Brunelli, Elena Badetti, Alessandro Bonetto, Bas G H Bokkers, Wim H de Jong, Andrew Williams, Sabina Halappanavar, Bengt Fadeel, Flemming R Cassee Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles. NanoImpact. 2021 Apr;22:100313. doi: 10.1016/j.impact.2021.100313.

Older

1.        Ahn K, Ensor D, Shama M, Ostraat M, Ramsden J, Jun Kanno, Mahmound Ghazikhansari, Ruben Lazos, Mary Gulumian, Flemming R. Cassee, Wim H. De Jong, Kisoo Jeon and Il Je Yu. Development of International Standard on Nano Aerosol Generation for Inhalation Toxicology Study. Toxicol Open Access 2017 3:127. doi: 10.4172/2476-2067.1000127

2.        Alberg T, Cassee FR, Groeng EC, Dybing E, Lovik M. Fine ambient particles from various sites in europe exerted a greater IgE adjuvant effect than coarse ambient particles in a mouse model. J Toxicol Environ Health A. 2009;72(1):1-13.

3.        Amato, F, Cassee, FR, Denier van der Gon, HAC, Gehrig, R, Gustafsson, M, Hafner, W, Harrison, RM, Jozwicka, M, Kelly, FJ, Moreno, T, Prevot, ASH, Schaap, M, Sunyer, J & Querol, X 2014, 'Urban air quality: the challenge of traffic non-exhaust emissions' Journal of hazardous materials, vol 275, pp. 31-36., 10.1016/j.jhazmat.2014.04.053.

4.        Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, et al. Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement. Inhal Toxicol. 2008 Jan;20(1):75-99.

5.        Bagate K, Meiring JJ, Cassee FR, Borm PJ. The effect of particulate matter on resistance and conductance vessels in the rat. Inhal Toxicol. 2004 Jun;16(6-7):431-6.

6.        Bagate K, Meiring JJ, Gerlofs-Nijland ME, Cassee FR, Borm PJ. Signal transduction pathways involved in particulate matter induced relaxation in rat aorta--spontaneous hypertensive versus Wistar Kyoto rats. Toxicol In Vitro. 2006 Feb;20(1):52-62.

7.        Bagate K, Meiring JJ, Gerlofs-Nijland ME, Cassee FR, Wiegand H, Osornio-Vargas A, et al. Ambient particulate matter affects cardiac recovery in a Langendorff ischemia model. Inhal Toxicol. 2006 Aug;18(9):633-43.

8.        Bagate K, Meiring JJ, Gerlofs-Nijland ME, Vincent R, Cassee FR, Borm PJ. Vascular effects of ambient particulate matter instillation in spontaneous hypertensive rats. Toxicol Appl Pharmacol. 2004 May 15;197(1):29-39.

9.        Becker S, Soukup JM, Sioutas C, Cassee FR. Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles. Exp Lung Res. 2003 Jan-Feb;29(1):29-44.

10.     Behndig AF, Mudway IS, Brown JL, Stenfors N, Helleday R, Duggan ST, et al. Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans. Eur Respir J. 2006 Feb;27(2):359-65.

11.     Bernal-Meléndez E, Lacroix MC, Bouillaud P, Callebert J, Olivier B, Persuy MA, Durieux D, Rousseau-Ralliard D, Aioun J, Cassee F, Couturier-Tarrade A, Valentino S, Chavatte-Palmer P, Schroeder H, Baly C. Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspring. Part Fibre Toxicol. 2019 Jan 17;16(1):5. doi: 10.1186/s12989-018-0288-7.

12.     Bessa MJ, Brandão F, Fokkens P, Cassee FR, Salmatonidis A, Viana M, Vulpoi A, Simon S, Monfort E, Teixeira JP, Fraga S. Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial in vitro model. Nanotoxicology. 2021 May;15(4):542-557. doi: 10.1080/17435390.2021.1897698. Epub 2021 Mar 18. 

13.     Bessa MJ, Brandão F, Fokkens PHB, Leseman DLAC, Boere AJF, Cassee FR, Salmatonidis A, Viana M, Vulpoi A, Simon S, Monfort E, Teixeira JP, Fraga S. In Vitro Toxicity of Industrially Relevant Engineered Nanoparticles in Human Alveolar Epithelial Cells: Air-Liquid Interface versus Submerged Cultures. Nanomaterials (Basel). 2021 Nov 27;11(12):3225. doi: 10.3390/nano11123225.

14.     Biswas S, Verma V, Schauer JJ, Cassee FR, Cho AK, Sioutas C. Oxidative potential of semi-volatile and non volatile particulate matter (PM) from heavy-duty vehicles retrofitted with emission control technologies. Environ Sci Technol. 2009 May 15;43(10):3905-12.

15.     Bleeker EA, de Jong WH, Geertsma RE, Groenewold M, Heugens EH, Koers-Jacquemijns M, van de Meent D, Popma JR, Rietveld AG, Wijnhoven SW, Cassee FR, Oomen AG Considerations on the EU definition of a nanomaterial: science to support policy making..Regul Toxicol Pharmacol. 2013 Feb;65(1):119-25. doi: 10.1016/j.yrtph.2012.11.007. Epub 2012 Nov 29.

16.     Boogaard H, Fischer PH, Janssen NA, Kos GP, Weijers EP, Cassee FR, van der Zee SC, de Hartog JJ, Meliefste K, Wang M, Brunekreef B, Hoek G Respiratory Effects of a Reduction in Outdoor Air Pollution Concentrations..Epidemiology. 2013 Jul 18.  

17.     Boogaard H, Janssen NA, Fischer PH, Kos GP, Weijers EP, Cassee FR, et al. Contrasts in oxidative potential and other particulate matter characteristics collected near major streets and background locations. Environ Health Perspect. 2012 Feb;120(2):185-91.

18.     Boogaard H, Janssen NA, Fischer PH, Kos GP, Weijers EP, Cassee FR, van der Zee SC, de Hartog JJ, Brunekreef B, Hoek G. Contrasts in oxidative potential and other particulate matter characteristics collected near major streets and background locations.Environ Health Perspect. 2012 Feb;120(2):185-91.  

19.     Boogaard H, Janssen NA, Fischer PH, Kos GP, Weijers EP, Cassee FR, van der Zee SC, de Hartog JJ, Meliefste K, Wang M, Brunekreef B, Hoek G. Impact of low emission zones and local traffic policies on ambient air pollution concentrations.Sci Total Environ. 2012 Oct 1;435-436:132-40.  

20.     Borm P, Cassee FR Ken Donaldson: retirement of a young mind..Part Fibre Toxicol. 2013 Mar 26;10:8. doi: 10.1186/1743-8977-10-8.   

21.     Borm P, Cassee FR, Oberdörster G. Lung particle overload: old school -new insights? Part Fibre Toxicol. 2015 Apr 26;12:10.

22.     Braakhuis HM, Cassee FR, Fokkens PH, de la Fonteyne LJ, Oomen AG, Krystek P, de Jong WH, van Loveren H, Park MV. Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study. Nanotoxicology. 2015 Feb 23:1-11.

23.     Braakhuis HM, Gosens I, Heringa MB, Oomen AG, Vandebriel RJ, Groenewold M, Cassee FR. Mechanism of Action of TiO2: Recommendations to Reduce Uncertainties Related to Carcinogenic Potential. Annu Rev Pharmacol Toxicol. 2021 Jan 6;61:203-223. doi: 10.1146/annurev-pharmtox-101419-100049. 

24.     Braakhuis, H, Gosens, I, Krystek, P, Boere, AJF, Cassee, F, Fokkens, PHD, Post, J, van Loveren, H & Park, MVDZ 2014, 'Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles' Particle and Fibre Toxicology [E], vol 11, pp. 49.

25.     Braakhuis, HM, Cassee, FR, Fokkens, PHB, de la Fonteyne, LJJ, Oomen, AG, Krystek, P, de Jong, WH, van Loveren, H & Park, MVDZ 2016, 'Identification of the appropriate dose metric for pulmonary inflammation of silver nanoparticles in an inhalation toxicity study' Nanotoxicology, vol 10, no. 1, pp. 63-73. DOI: 10.3109/17435390.2015.1012184

26.     Braakhuis, HM, Oomen, AG & Cassee, FR 2016, 'Grouping nanomaterials to predict their potential to induce pulmonary inflammation' Toxicology and Applied Pharmacology, vol 299, pp. 3-7. DOI: 10.1016/j.taap.2015.11.009

27.     Brandsma CA, Hylkema MN, Luinge MA, Geerlings M, Klok PA, Cassee FR, et al. Nitrogen dioxide exposure attenuates cigarette smoke-induced cytokine production in mice. Inhal Toxicol. 2008 Jan;20(2):183-9.

28.     Camaioni A, Massimiani M, Lacconi V, Magrini A, Salustri A, Sotiriou GA, Singh D, Bitounis D, Bocca B, Pino A, Barone F, Prota V, Iavicoli I, Scimeca M, Bonanno E, Cassee FR, Demokritou P, Pietroiusti A, Campagnolo L. Silica encapsulation of ZnO nanoparticles reduces their toxicity for cumulus cell-oocyte-complex expansion. Part Fibre Toxicol. 2021 Sep 3;18(1):33. doi: 10.1186/s12989-021-00424-z.

29.     Campagnolo L, Massimiani M, Vecchione L, Piccirilli D, Toschi N, Magrini A, Bonanno E, Scimeca M, Castagnozzi L, Buonanno G, Stabile L, Cubadda F, Aureli F, Fokkens PH, Kreyling WG, Cassee FR, Pietroiusti A. Silver Nanoparticles Inhaled during Pregnancy Reach and Affect the Placenta and the Foetus. Nanotoxicology. 2017 Jun 16:1-36. 

30.     Cassee FR, Arts JH, Fokkens PH, Spoor SM, Boere AJ, van Bree L, et al. Pulmonary effects of ultrafine and fine ammonium salts aerosols in healthy and monocrotaline-treated rats following short-term exposure. Inhal Toxicol. 2002 Dec;14(12):1215-29.

31.     Cassee FR, Arts JH, Groten JP, Feron VJ. Sensory irritation to mixtures of formaldehyde, acrolein, and acetaldehyde in rats. Arch Toxicol. 1996;70(6):329-37.

32.     Cassee FR, Boere AJ, Bos J, Fokkens PH, Dormans JA, van Loveren H. Effects of diesel exhaust enriched concentrated PM2.5 in ozone preexposed or monocrotaline-treated rats. Inhal Toxicol. 2002 Jul;14(7):721-43.

33.     Cassee FR, Boere AJ, Fokkens PH, Leseman DL, Sioutas C, Kooter IM, et al. Inhalation of concentrated particulate matter produces pulmonary inflammation and systemic biological effects in compromised rats. J Toxicol Environ Health A. 2005 May 28;68(10):773-96.

34.     Cassee FR, Campbell A, Boere AJ, McLean SG, Duffin R, Krystek P, Gosens I, Miller MR. The biological effects of subacute inhalation of diesel exhaust following addition of cerium oxide nanoparticles in atherosclerosis-prone mice. Environ Res. 2012 May;115:1-10.  

35.     Cassee FR, de Burbure CY, Rambali B, Vleeming W, van de Kuil A, van Steeg H, et al. Subchronic inhalation of mixtures of cigarette smoke constituents in Xpa-/-p53+/- knock-out mice: a comparison of intermittent with semi-continuous exposure to acetaldehyde, formaldehyde, and acrolein. Food Chem Toxicol. 2008 Feb;46(2):527-36.

36.     Cassee FR, Feron VJ. Biochemical and histopathological changes in nasal epithelium of rats after 3-day intermittent exposure to formaldehyde and ozone alone or in combination. Toxicol Lett. 1994 Jun;72(1-3):257-68.

37.     Cassee FR, Groten JP, Feron VJ. Changes in the nasal epithelium of rats exposed by inhalation to mixtures of formaldehyde, acetaldehyde, and acrolein. Fundam Appl Toxicol. 1996 Feb;29(2):208-18.

38.     Cassee FR, Groten JP, van Bladeren PJ, Feron VJ. Toxicological evaluation and risk assessment of chemical mixtures. Crit Rev Toxicol. 1998 Jan;28(1):73-101.

39.     Cassee FR, Muijser H, Duistermaat E, Freijer JJ, Geerse KB, Marijnissen JC, et al. Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model. Arch Toxicol. 2002 Jun;76(5-6):277-86.

40.     Cassee FR, Stenhuis WH, Groten JP, Feron VJ. Toxicity of formaldehyde and acrolein mixtures: in vitro studies using nasal epithelial cells. Exp Toxicol Pathol. 1996 Nov;48(6):481-3.

41.     Cassee FR, van Balen EC, Singh C, Green D, Muijser H, Weinstein J, et al. Exposure, health and ecological effects review of engineered nanoscale cerium and cerium oxide associated with its use as a fuel additive. Crit Rev Toxicol. 2011 Mar;41(3):213-29.

42.     Cassee FR. Reflections on the scope and the future of Particle and Fibre Toxicology. Part Fibre Toxicol. 2011;8:13.

43.     Cassee, FR & Brunekreef, B 2014, 'Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project' Inhalation toxicology, vol 26, no. 3, pp. 141-165., 10.3109/08958378.2013.861884

44.     Cheung KL, Polidori A, Ntziachristos L, Tzamkiozis T, Samaras Z, Cassee FR, et al. Chemical characteristics and oxidative potential of particulate matter emissions from gasoline, diesel, and biodiesel cars. Environ Sci Technol. 2009 Aug 15;43(16):6334-40.

44.Feron VJ, Cassee FR, Groten JP, van Vliet PW, van Zorge JA. International issues on human health effects of exposure to chemical mixtures. Environ Health Perspect. 2002 Dec;110 Suppl 6:893-9.

45.     Costa PM, Gosens I, Williams A, Farcal L, Pantano D, Brown DM, Stone V, Cassee FR, Halappanavar S, Fadeel B. Transcriptional profiling reveals gene expression changes associated with inflammation and cell proliferation following short-term inhalation exposure to copper oxide nanoparticles. J Appl Toxicol. 2018 Mar;38(3):385-397. doi: 10.1002/jat.3548.

46.     De Jong WH, De Rijk E, Bonetto A, Wohlleben W, Stone V, Brunelli A, Badetti E, Marcomini A, Gosens I, Cassee FR. Toxicity of copper oxide and basic copper carbonate nanoparticles after short-term oral exposure in rats. Nanotoxicology. 2019 Feb;13(1):50-72. doi: 10.1080/17435390.2018.1530390.

47.     Dekkers S, Ma-Hock L, Lynch I, Russ M, Miller MR, Schins RPF, Keller J, Römer I, Küttler K, Strauss V, De Jong WH, Landsiedel R, Cassee FR. Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms. Inhal Toxicol. 2018 Oct 4:1-14.

48.     Dekkers S, Miller MR, Schins RPF, Römer I, Russ M, Vandebriel RJ, Lynch I, Belinga-Desaunay MF, Valsami-Jones E, Connell SP, Smith IP, Duffin R, Boere JAF, Heusinkveld HJ, Albrecht C, de Jong WH, Cassee FR. The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. Nanotoxicology. 2017 Aug;11(6):794-808

49.     Dekkers, S, Oomen, AG, Bleeker, EAJ, Vandebriel, RJ, Micheletti, C, Cabellos, J, Janer, G, Fuentes, N, Vázquez-Campos, S, Borges, T, Silva, MJ, Prina-Mello, A, Movia, D, Nesslany, F, Ribeiro, AR, Leite, PE, Groenewold, M, Cassee, FR, Sips, AJAM, Dijkzeul, A, van Teunenbroek, T & Wijnhoven, SWP 2016, 'Towards a nanospecific approach for risk assessment' Regulatory Toxicology and Pharmacology, vol 80, pp. 46-59. DOI: 10.1016/j.yrtph.2016.05.037

50.     Feron VJ, Cassee FR, Groten JP. Toxicology of chemical mixtures: international perspective. Environ Health Perspect. 1998 Dec;106 Suppl 6:1281-9.

51.     Feron VJ, Groten JP, Jonker D, Cassee FR, van Bladeren PJ. Toxicology of chemical mixtures: challenges for today and the future. Toxicology. 1995 Dec 28;105(2-3):415-27.

52.     Feron VJ, Groten JP, van Zorge JA, Cassee FR, Jonker D, van Bladeren PJ. Toxicity studies in rats of simple mixtures of chemicals with the same or different target organs. Toxicol Lett. 1995 Dec;82-83:505-12.

53.     Feron VJ, Til HP, de Vrijer F, Woutersen RA, Cassee FR, van Bladeren PJ. Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment. Mutat Res. 1991 Mar-Apr;259(3-4):363-85.

54.     Feron VJ, Woutersen RA, Arts JH, Cassee FR, de Vrijer F, van Bladeren PJ. Safety evaluation of the mixture of chemicals at a specific workplace: theoretical considerations and a suggested two-step procedure. Toxicol Lett. 1995 Feb;76(1):47-55.

55.     Fischer PH, Marra M, Ameling CB, Janssen N, Cassee FR. Trends in relative risk estimates for the association between air pollution and mortality in The Netherlands, 1992-2006. Environ Res. 2011 Jan;111(1):94-100.

56.     Freney EJ, Heal MR, Donovan RJ, Mills NL, Donaldson K, Newby DE, et al. A single-particle characterization of a mobile Versatile Aerosol Concentration Enrichment System for exposure studies. Part Fibre Toxicol. 2006;3:8.

57.     Geraets L, Oomen AG, Schroeter JD, Coleman VA, Cassee FR. Tissue Distribution of Inhaled Micro- and Nano-sized Cerium Oxide Particles in Rats: Results from a 28-day Exposure Study. Toxicol Sci. 2012 Mar 19.

58.     Gerlofs-Nijland ME, Boere AJ, Leseman DL, Dormans JA, Sandstrom T, Salonen RO, et al. Effects of particulate matter on the pulmonary and vascular system: time course in spontaneously hypertensive rats. Part Fibre Toxicol. 2005 Mar 24;2(1):2.

59.     Gerlofs-Nijland ME, Bokkers BGH, Sachse H, Reijnders JJE, Gustafsson M, Boere AJF, Fokkens PFH, Leseman DLAC, Augsburg K, Cassee FR. Inhalation toxicity profiles of particulate matter: a comparison between brake wear with other sources of emission. Inhal Toxicol. 2019 Feb;31(3):89-98. doi: 10.1080/08958378.2019.1606365. Epub 2019 May 8.

60.     Gerlofs-Nijland ME, Dormans JA, Bloemen HJ, Leseman DL, John A, Boere F, et al. Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles. Inhal Toxicol. 2007 Oct;19(13):1055-69.

61.     Gerlofs-Nijland ME, Rummelhard M, Boere AJ, Leseman DL, Duffin R, Schins RP, et al. Particle induced toxicity in relation to transition metal and polycyclic aromatic hydrocarbon contents. Environ Sci Technol. 2009 Jul 1;43(13):4729-36.

62.     Gerlofs-Nijland ME, Totlandsdal AI, Kilinc E, Boere AJ, Fokkens PH, Leseman DL, et al. Pulmonary and cardiovascular effects of traffic-related particulate matter: 4-week exposure of rats to roadside and diesel engine exhaust particles. Inhal Toxicol. 2010 Dec;22(14):1162-73.

63.     Gerlofs-Nijland ME, Totlandsdal AI, Tzamkiozis T, Leseman DL, Samaras Z, Låg M, Schwarze P, Ntziachristos L, Cassee FR Cell toxicity and oxidative potential of engine exhaust particles: impact of using particulate filter or biodiesel fuel blend..Environ Sci Technol. 2013 Jun 4;47(11):5931-8. doi: 10.1021/es305330y. Epub 2013 May 20.

64.     Gerlofs-Nijland ME, van Berlo D, Cassee FR, Schins RP, Wang K, Campbell A. Effect of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol. 2010;7:12.

65.     Gosens I, Costa PM, Olsson M, Stone V, Costa AL, Brunelli A, Badetti E, Bonetto A, Bokkers BGH, de Jong WH, Williams A, Halappanavar S, Fadeel B, Cassee FR. Pulmonary toxicity and gene expression changes after short-term inhalation exposure to surface-modified copper oxide nanoparticles. NanoImpact. 2021 Apr;22:100313. doi: 10.1016/j.impact.2021.100313. Epub 2021 Mar 26. 

66.     Gosens I, Kermanizadeh A, Jacobsen NR, Lenz AG, Bokkers B, de Jong WH, Krystek P, Tran L, Stone V, Wallin H, Stoeger T, Cassee FR. Comparative hazard identification by a single dose lung exposure of zinc oxide and silver nanomaterials in mice. PLoS One. 2015 May 12;10(5):e0126934.

67.     Gosens I, Mathijssen LE, Bokkers BG, Muijser H, Cassee FR Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats..Nanotoxicology. 2013 Jul 8.  

68.     Gosens I, Post JA, de la Fonteyne LJ, Jansen EH, Geus JW, Cassee FR, et al. Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation. Part Fibre Toxicol. 2010;7(1):37.

69.     Gosens, I, Cassee, FR, Zanella, M, Manodori, L, Brunelli, A, Costa, AL, Bokkers, BGH, de Jong, WH, Brown, D, Hristozov, D & Stone, V 2016, 'Organ burden and pulmonary toxicity of nano-sized copper (II) oxide particles after short-term inhalation exposure' Nanotoxicology, pp. 1-12. DOI: 10.3109/17435390.2016.1172678

70.     Gosens, I, Mathijssen, LEAM, Bokkers, BGH, Muijser, H & Cassee, FR 2014, 'Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats' Nanotoxicology, vol 8, no. 6, pp. 643-653., 10.3109/17435390.2013.815814

71.     Guastadisegni C, Kelly FJ, Cassee FR, Gerlofs-Nijland ME, Janssen NA, Pozzi R, et al. Determinants of the proinflammatory action of ambient particulate matter in immortalized murine macrophages. Environ Health Perspect. 2010 Dec;118(12):1728-34.

72.     Gulumian M, Cassee FR. Safe by design (SbD) and nanotechnology: a much-discussed topic with a prudence? Part Fibre Toxicol. 2021 Aug 23;18(1):32. doi: 10.1186/s12989-021-00423-0.

73.     Hagens WI, Oomen AG, de Jong WH, Cassee FR, Sips AJ. What do we (need to) know about the kinetic properties of nanoparticles in the body? Regul Toxicol Pharmacol. 2007 Dec;49(3):217-29.

74.     Halatek T, Stepnik M, Stetkiewicz J, Krajnow A, Kur B, Szymczak W, et al. The inflammatory response in lungs of rats exposed on the airborne particles collected during different seasons in four European cities. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2011 Nov;46(13):1469-81.

75.     Happo MS, Salonen RO, Halinen AI, Jalava PI, Pennanen AS, Dormans JA, et al. Inflammation and tissue damage in mouse lung by single and repeated dosing of urban air coarse and fine particles collected from six European cities. Inhal Toxicol. 2010 Apr;22(5):402-16.

76.     Hassing C, Twickler M, Brunekreef B, Cassee F, Doevendans P, Kastelein J, et al. Particulate air pollution, coronary heart disease and individual risk assessment: a general overview. Eur J Cardiovasc Prev Rehabil. 2009 Feb;16(1):10-5.

77.     Hassing HC, Twickler TB, Kastelein JJ, Cramer MJ, Cassee FR. Air pollution as noxious environmental factor in the development of cardiovascular disease. Neth J Med. 2009 Apr;67(4):116-21.

78.     He RW, Braakhuis HM, Vandebriel RJ, Staal YCM, Gremmer ER, Fokkens PHB, Kemp C, Vermeulen J, Westerink RHS, Cassee FR. Optimization of an air-liquid interface in vitro cell co-culture model to estimate the hazard of aerosol exposures. J Aerosol Sci. 2021 Mar;153:105703. doi: 10.1016/j.jaerosci.2020.105703.

79.     He RW, Houtzager MMG, Jongeneel WP, Westerink RHS, Cassee FR. In vitro hazard characterization of simulated aircraft cabin bleed-air contamination in lung models using an air-liquid interface (ALI) exposure system. Environ Int. 2021 Nov;156:106718. doi: 10.1016/j.envint.2021.106718. Epub 2021 Jun 21.

80.     He R-W, Shirmohammadi F, Gerlofs-Nijland ME, Sioutas C, Cassee FR. Pro-inflammatory responses to PM0.25 from airport and urban traffic emissions. Sci Total Environ 2018; 640-641:997-1003

81.     Hellack, B, Yang, A, Cassee, FR, Janssen, NAH, Schins, RPF & Kuhlbusch, TAJ 2014, 'Intrinsic hydroxyl radical generation measurements directly from sampled filters as a metric for the oxidative potential of ambient particulate matter' Journal of aerosol science, vol 72, pp. 47-55., 10.1016/j.jaerosci.2014.02.003

82.     Hetland RB, Cassee FR, Lag M, Refsnes M, Dybing E, Schwarze PE. Cytokine release from alveolar macrophages exposed to ambient particulate matter: heterogeneity in relation to size, city and season. Part Fibre Toxicol. 2005 Aug 17;2:4.

83.     Hetland RB, Cassee FR, Refsnes M, Schwarze PE, Lag M, Boere AJ, et al. Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions. Toxicol In Vitro. 2004 Apr;18(2):203-12.

84.     Heusinkveld, HJ, Wahle, T, Campbell, A, Westerink, RHS, Tran, L, Johnston, H, Stone, V, Cassee, FR & Schins, RPF 2016, 'Neurodegenerative and neurological disorders by small inhaled particles' NeuroToxicology, vol 56, pp. 94-106. DOI: 10.1016/j.neuro.2016.07.007

85.     Hoogervorst EM, de Vries A, Beems RB, van Oostrom CT, Wester PW, Vos JG, et al. Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice. Carcinogenesis. 2003 Mar;24(3):613-9.

86.     Hougaard KS, Campagnolo L, Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D, Valentino S, Park MV, de Jong WH, Wolterink G, Piersma AH, Ross BL, Hutchison GR, Hansen JS, Vogel U, Jackson P, Slama R, Pietroiusti A, Cassee FR. A perspective on the developmental toxicity of inhaled nanoparticles.Reprod Toxicol. 2015 Jun 4. pii: S0890-6238(15)00106-9.

87.     Hristozov D, Pizzol L, Basei G, Zabeo A, Mackevica A, Hansen SF, Gosens I, Cassee FR, de Jong W, Koivisto AJ, Neubauer N, Sanchez Jimenez A, Semenzin E, Subramanian V, Fransman W, Jensen KA, Wohlleben W, Stone V, Marcomini A. Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives. Nanotoxicology. 2018 Jun 12:1-19. doi: 10.1080/17435390.2018.1472314.

88.     Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF. Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease. Part Fibre Toxicol. 2017 Aug 30;14(1):35.

89.     Hunt G, Lynch I, Cassee F, Handy R, Fernandes TF,  Berges M, Kuhlbusch TA, Dusinska M, Riediker M: Towards a Consensus View on Understanding Nanomaterials Hazards and Managing Exposure: Knowledge Gaps and Recommendations, Special issue Nanotoxicology, Materials 2013, 6(3), 1090-1117; doi:10.3390/ma6031090

90.     Jalava PI, Hirvonen MR, Sillanpaa M, Pennanen AS, Happo MS, Hillamo R, et al. Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line. Inhal Toxicol. 2009 Oct;21(12):994-1006.

91.     Janssen NA, Fischer P, Marra M, Ameling C, Cassee FR Short-term effects of PM2.5, PM10 and PM2.5-10 on daily mortality in the Netherlands..Sci Total Environ. 2013 Jun 17;463-464C:20-26. doi: 10.1016/j.scitotenv.2013.05.062 

92.     Janssen NA, Hoek G, Simic-Lawson M, Fischer P, Bree LV, Brink HT, et al. Black carbon as an Additional Indicator of the Adverse Health Effects of Airborne Particles Compared to PM10 and PM2.5. Environ Health Perspect. 2011 Aug 2.

93.     Janssen NA, Hoek G, Simic-Lawson M, Fischer P, van Bree L, ten Brink H, et al. Black carbon as an additional indicator of the adverse health effects of airborne particles compared with PM10 and PM2.5. Environ Health Perspect. 2011 Dec;119(12):1691-9.

94.     Janssen NA, Hoek G, Simic-Lawson M, Fischer P, van Bree L, ten Brink H, Keuken M, Atkinson RW, Anderson HR, Brunekreef B, Cassee FR. Black carbon as an additional indicator of the adverse health effects of airborne particles compared with PM10 and PM2.5.Environ Health Perspect. 2011 Dec;119(12):1691-9.. Review.

95.     Janssen NA, Strak M, Yang A, Hellack B, Kelly FJ, Kuhlbusch TA, Harrison RM, Brunekreef B, Cassee FR, Steenhof M, Hoek G. Associations between three specific a-cellular measures of the oxidative potential of particulate matter and markers of acute airway and nasal inflammation in healthy volunteers. Occup Environ Med. 2015 Jan;72(1):49-56.

96.     Janssen, NAH, Yang, A, Strak, M, Steenhof, M, Hellack, B, Gerlofs-Nijland, ME, Kuhlbusch, T, Kelly, F, Harrison, RM, Brunekreef, B, Hoek, G & Cassee, F 2014, 'Oxidative potential of particulate matter collected at sites with different source characteristics' Science of the Total Environment, vol 472, pp. 572-581., 10.1016/j.scitotenv.2013.11.099

97.     Jiménez-Chávez A, Solorio-Rodríguez A, Escamilla-Rivera V, Leseman D, Morales-Rubio R, Uribe-Ramírez M, Campos-Villegas L, Medina-Ramírez IE, Arreola-Mendoza L, Cassee FR, De Vizcaya-Ruiz A. Inflammatory response in human alveolar epithelial cells after TiO2 NPs or ZnO NPs exposure: Inhibition of surfactant protein A expression as an indicator for loss of lung function. Environ Toxicol Pharmacol. 2021 Aug;86:103654. doi: 10.1016/j.etap.2021.103654. Epub 2021 Apr 3. 

98.     Kermanizadeh, A, Gosens, I, MacCalman, L, Johnston, H, Danielsen, PH, Jacobsen, NR, Lenz, A-G, Fernandes, T, Schins, RPF, Cassee, FR, Wallin, H, Kreyling, W, Stoeger, T, Loft, S, Møller, P, Tran, L & Stone, V 2016, 'A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health-ENPRA Project-The Highlights, Limitations, and Current and Future Challenges' Journal of Toxicology and Environmental Health-Part B-Critical Reviews, vol 19, no. 1, pp. 1-28. DOI: 10.1080/10937404.2015.1126210

99.     Kilinc E, Van Oerle R, Borissoff JI, Oschatz C, Gerlofs-Nijland ME, Janssen NA, et al. Factor XII activation is essential to sustain the procoagulant effects of particulate matter. J Thromb Haemost. 2011 Jul;9(7):1359-67.

100.   Kilinç E, Van Oerle R, Borissoff JI, Oschatz C, Gerlofs-Nijland ME, Janssen NA, Cassee FR, Sandström T, Renné T, Ten Cate H, Spronk HM. Factor XII activation is essential to sustain the procoagulant effects of particulate matter.J Thromb Haemost. 2011 Jul;9(7):1359-67. doi: 10.1111/j.1538-7836.2011.04280.x.

101.   Kleinman MT, Sioutas C, Chang MC, Boere AJ, Cassee FR. Ambient fine and coarse particle suppression of alveolar macrophage functions. Toxicol Lett. 2003 Feb 3;137(3):151-8.

102.   Knol AB, de Hartog JJ, Boogaard H, Slottje P, van der Sluijs JP, Lebret E, et al. Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways. Part Fibre Toxicol. 2009;6:19.

103.   Kocbach A, Li Y, Yttri KE, Cassee FR, Schwarze PE, Namork E. Physicochemical characterisation of combustion particles from vehicle exhaust and residential wood smoke. Part Fibre Toxicol. 2006;3:1.

104.   Koivisto AJ, Kling KI, Levin M, Fransman W, Gosens I, Cassee FR, Jensen KA.  First order risk assessment for nanoparticle inhalation exposure during injection molding of polypropylene composites and production of tungsten-carbide-cobalt fine powder based upon pulmonary inflammation and surface area dose.  NanoImpact 2017, 6, pp. 30-38

105.   Kooter I, Pennings J, Opperhuizen A, Cassee F. Gene expression pattern in spontaneously hypertensive rats exposed to urban particulate matter (EHC-93). Inhal Toxicol. 2005 Jan;17(1):53-65.

106.   Kooter IM, Boere AJ, Fokkens PH, Leseman DL, Dormans JA, Cassee FR. Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: experimental controlled study. Part Fibre Toxicol. 2006;3:7.

107.   Kooter IM, Frederix K, Spronk HM, Boere AJ, Leseman DL, van Steeg H, et al. Lung inflammation and thrombogenic responses in a time course study of Csb mice exposed to ozone. J Appl Toxicol. 2008 Aug;28(6):779-87.

108.   Kooter IM, Gerlofs-Nijland ME, Boere AJ, Leseman DL, Fokkens PH, Spronk HM, Frederix K, Ten Cate H, Knaapen AM, Vreman HJ, Cassee FR.. Diesel engine exhaust initiates a sequence of pulmonary and cardiovascular effects in rats. J Toxicol. 2010;2010:206057.

109.   Kooter IM, Pennings JL, Fokkens PH, Leseman DL, Boere AJ, Gerlofs-Nijland ME, et al. Ozone induces clear cellular and molecular responses in the mouse lung independently of the transcription-coupled repair status. J Appl Physiol. 2007 Mar;102(3):1185-92.

110.   Lammers A, Neerincx AH, Vijverberg SJH, Longo C, Janssen NAH, Boere AJF, Brinkman P, Cassee FR, van der Zee AHM. The Impact of Short-Term Exposure to Air Pollution on the Exhaled Breath of Healthy Adults. Sensors (Basel). 2021 Apr 4;21(7):2518. doi: 10.3390/s21072518.. 

111.   Langrish JP, Li X, Wang S, Lee MM, Barnes GD, Miller MR, et al. Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect. 2011 Mar;120(3):367-72.

112.   Langrish JP, Mills NL, Chan JK, Leseman DL, Aitken RJ, Fokkens PH, et al. Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask. Part Fibre Toxicol. 2009;6:8.

113.   Langrish, JP, Watts, SJ, Hunter, AJ, Shah, ASV, Bosson, JA, Unosson, J, Barath, S, Lundbäck, M, Cassee, FR, Donaldson, K, Sandström, T, Blomberg, A, Newby, DE & Mills, NL 2014, 'Controlled exposures to air pollutants and risk of cardiac arrhythmia' Environmental Health Perspectives, vol 122, no. 7, pp. 747-53., 10.1289/ehp.1307337

114.   Lippmann M, Cassee FR, Costa DL, Costantini M, van Erp AM, Gordon T. International Workshop on the Design and Analysis of Experimental Studies using PM Concentrator Technologies, Boston, May 5, 2004. Inhal Toxicol. 2005 Dec 15;17(14):839-50.

115.   Loxham M, Cooper MJ, Gerlofs-Nijland ME, Cassee FR, Davies DE, Palmer MR, Teagle DA Physicochemical characterization of airborne particulate matter at a mainline underground railway station..Environ Sci Technol. 2013 Apr 16;47(8):3614-22. doi: 10.1021/es304481m. Epub 2013 Apr 2.

116.   Loxham M, Morgan-Walsh RJ, Cooper MJ, Blume C, Swindle EJ, Dennison PW, Howarth PH, Cassee FR, Teagle DA, Palmer MR, Davies DE. The effects on bronchial epithelial mucociliary cultures of coarse, fine, and ultrafine particulate matter from an underground railway station. Toxicol Sci. 2015 May;145(1):98-107

117.   Lucking AJ, Lundback M, Barath SL, Mills NL, Sidhu MK, Langrish JP, et al. Particle traps prevent adverse vascular and prothrombotic effects of diesel engine exhaust inhalation in men. Circulation. 2011 Apr 26;123(16):1721-8.

118.   Lucking AJ, Lundback M, Mills NL, Faratian D, Barath SL, Pourazar J, et al. Diesel exhaust inhalation increases thrombus formation in man. Eur Heart J. 2008 Dec;29(24):3043-51.

119.   Lung, S, Cassee, FR, Gosens, I & Campbell, A 2014, 'Brain suppression of AP-1 by inhaled diesel exhaust and reversal by cerium oxide nanoparticles' Inhalation toxicology, vol 26, no. 10, pp. 636-41., 10.3109/08958378.2014.948651

120.   Martikainen MV, Aakko-Saksa P, van den Broek L, Cassee FR, Carare RO, Chew S, Dinnyes A, Giugno R, Kanninen KM, Malm T, Muala A, Nedergaard M, Oudin A, Oyola P, Pfeiffer TV, Rönkkö T, Saarikoski S, Sandström T, Schins RPF, Topinka J, Yang M, Zeng X, Westerink RHS, Jalava PI. TUBE Project: Transport-Derived Ultrafines and the Brain Effects. Int J Environ Res Public Health. 2021 Dec 28;19(1):311. doi: 10.3390/ijerph19010311.

121.   Marx, U, Andersson, TB, Bahinski, A, Beilmann, M, Beken, S, Cassee, FR, Cirit, M, Daneshian, M, Fitzpatrick, S, Frey, O, Gaertner, C, Giese, C, Griffith, L, Hartung, T, Heringa, MB, Hoeng, J, de Jong, WH, Kojima, H, Kuehnl, J, Leist, M, Luch, A, Maschmeyer, I, Sakharov, D, Sips, AJAM, Steger-Hartmann, T, Tagle, DA, Tonevitsky, A, Tralau, T, Tsyb, S, van de Stolpe, A, Vandebriel, R, Vulto, P, Wang, J, Wiest, J, Rodenburg, M & Roth, A 2016, 'Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing' ALTEX. DOI: 10.14573/altex.1603161

122.   Miller MR, Raftis JB, Langrish JP, McLean SG, Samutrtai P, Connell SP, Wilson S, Vesey AT, Fokkens PHB, Boere AJF, Krystek P, Campbell CJ, Hadoke PWF, Donaldson K, Cassee FR, Newby DE, Duffin R, Mills NL. Inhaled Nanoparticles Accumulate at Sites of Vascular Disease.ACS Nano. 2017 May 23;11(5):4542-4552

123.   Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, et al. Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am J Respir Crit Care Med. 2006 Feb 15;173(4):426-31.

124.   Mills NL, Donaldson K, Hadoke PW, Boon NA, MacNee W, Cassee FR, et al. Adverse cardiovascular effects of air pollution. Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):36-44.

125.   Mills NL, Miller MR, Lucking AJ, Beveridge J, Flint L, Boere AJ, Fokkens PH, Boon NA, Sandstrom T, Blomberg A, Duffin R, Donaldson K, Hadoke PW, Cassee FR, Newby DE. Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation.Eur Heart J. 2011 Nov;32(21):2660-71.

126.   Mills NL, Miller MR, Lucking AJ, Beveridge J, Flint L, Boere AJ, Fokkens PH, Boon NA, Sandstrom T, Blomberg A, Duffin R, Donaldson K, Hadoke PW, Cassee FR, Newby DE.

127.   Mills NL, Robinson SD, Fokkens PH, Leseman DL, Miller MR, Anderson D, et al. Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease. Environ Health Perspect. 2008 Jun;116(6):709-15.

128.   Møller P, Wallin H, Cassee FR, Loft S. Does intranasal instillation TiO2 cause pulmonary tumorigenesis in male mice?Environ Toxicol. 2018 Nov;33(11):1095-1096. doi: 10.1002/tox.22490.

129.   Møller P, Wallin H, Cassee FR, Loft S. Does intranasal instillation TiO2 cause pulmonary tumorigenesis in male mice? Environ Toxicol. 2017 Oct 21. doi: 10.1002/tox.22490.

130.   Neurobehavioral effects of exposure to traffic-related air pollution and transportation noise in primary schoolchildren. van Kempen E, Fischer P, Janssen N, Houthuijs D, van Kamp I, Stansfeld S, Cassee F. Environ Res. 2012 May;115:18-25.  

131.   Park MVDZ, Bleeker EAJ, Brand W, Cassee FR, van Elk M, Gosens I, de Jong WH, Meesters JAJ, Peijnenburg WJGM, Quik JTK, Vandebriel RJ, Sips AJAM. Considerations for Safe Innovation: The Case of Graphene. ACS Nano. 2017 Sep 26. doi: 10.1021/acsnano.7b04120

132.   Poland, CA, Miller, MR, Duffin, R & Cassee, F 2014, 'The elephant in the room: reproducibility in toxicology' Particle and Fibre Toxicology [E], vol 11, pp. 42., 10.1186/s12989-014-0042-8

133.   Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F. Particle toxicology and health - where are we? Part Fibre Toxicol. 2019 Apr 23;16(1):19. doi: 10.1186/s12989-019-0302-8.

134.   Rousseau-Ralliard D, Richard C, Hoarau P, Lallemand MS, Morillon L, Aubrière MC, Valentino SA, Dahirel M, Guinot M, Fournier N, Morin G, Mourier E, Camous S, Slama R, Cassee FR, Couturier-Tarrade A, Chavatte-Palmer P. Prenatal air pollution exposure to diesel exhaust induces cardiometabolic disorders in adulthood in a sex-specific manner. Environ Res. 2021 Sep;200:111690. doi: 10.1016/j.envres.2021.111690. Epub 2021 Jul 14.

135.   Rousseau-Ralliard D, Valentino SA, Aubrière MC, Dahirel M, Lallemand MS, Archilla C, Jouneau L, Fournier N, Richard C, Aioun J, Vitorino Carvalho A, Jérôme L, Slama R, Duranthon V, Cassee FR, Chavatte-Palmer P, Couturier-Tarrade A. Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and foetal metabolism in rabbits: preliminary results. Sci Rep. 2019 Jul 4;9(1):9710. doi: 10.1038/s41598-019-46130-x.

136.   Rudez G, Janssen NA, Kilinc E, Leebeek FW, Gerlofs-Nijland ME, Spronk HM, et al. Effects of ambient air pollution on hemostasis and inflammation. Environ Health Perspect. 2009 Jun;117(6):995-1001.

137.   Sandstrom T, Cassee FR, Salonen R, Dybing E. Recent outcomes in European multicentre projects on ambient particulate air pollution. Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):261-8.

138.   Schlesinger RB, Cassee F. Atmospheric secondary inorganic particulate matter: the toxicological perspective as a basis for health effects risk assessment. Inhal Toxicol. 2003 Mar;15(3):197-235.

139.   Schmid O, Cassee FR.On the pivotal role of dose for particle toxicology and risk assessment: exposure is a poor surrogate for delivered dose. Part Fibre Toxicol. 2017 Dec 8;14(1):52. doi: 10.1186/s12989-017-0233-1.

140.   Schwarze PE, Ovrevik J, Hetland RB, Becher R, Cassee FR, Lag M, et al. Importance of size and composition of particles for effects on cells in vitro. Inhal Toxicol. 2007;19 Suppl 1:17-22.

141.   Selley L, Lammers A, Le Guennec A, Pirhadi M, Sioutas C, Janssen N, Maitland-van der Zee AH, Mudway I, Cassee F. Alterations to the urinary metabolome following semi-controlled short exposures to ultrafine particles at a major airport. Int J Hyg Environ Health. 2021 Aug;237:113803. doi: 10.1016/j.ijheh.2021.113803. Epub 2021 Sep 10. 

142.   Steenhof M, Gosens I, Strak M, Godri KJ, Hoek G, Cassee FR, Mudway IS, Kelly FJ, Harrison RM, Lebret E, Brunekreef B, Janssen NA, Pieters RH. In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential--the RAPTES project. Part Fibre Toxicol. 2011 Sep 2;8:26.

143.   Steenhof M, Mudway IS, Gosens I, Hoek G, Godri KJ, Kelly FJ, Harrison RM, Pieters RH, Cassee FR, Lebret E, Brunekreef BA, Strak M, Janssen NA Acute nasal pro-inflammatory response to air pollution depends on characteristics other than particle mass concentration or oxidative potential: the RAPTES project..Occup Environ Med. 2013 May;70(5):341-8. doi: 10.1136/oemed-2012-100993. Epub 2013 Feb 21.

144.   Steerenberg P, Verlaan A, De Klerk A, Boere A, Loveren H, Cassee F. Sensitivity to ozone, diesel exhaust particles, and standardized ambient particulate matter in rats with a listeria monocytogenes-induced respiratory infection. Inhal Toxicol. 2004 May;16(5):311-7.

145.   Steerenberg PA, van Amelsvoort L, Lovik M, Hetland RB, Alberg T, Halatek T, et al. Relation between sources of particulate air pollution and biological effect parameters in samples from four European cities: an exploratory study. Inhal Toxicol. 2006 May;18(5):333-46.

146.   Steerenberg PA, Withagen CE, van Dalen WJ, Dormans JA, Cassee FR, Heisterkamp SH, et al. Adjuvant activity of ambient particulate matter of different sites, sizes, and seasons in a respiratory allergy mouse model. Toxicol Appl Pharmacol. 2004 Nov 1;200(3):186-200.

147.   Steerenberg PA, Withagen CE, van Dalen WJ, Dormans JA, Heisterkamp SH, van Loveren H, et al. Dose dependency of adjuvant activity of particulate matter from five European sites in three seasons in an ovalbumin-mouse model. Inhal Toxicol. 2005 Mar;17(3):133-45.

148.   Stone V, Miller MR, Clift MJ, Elder A, Mills NL, Møller P, Schins RP, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TA, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR.Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge. Environ Health Perspect. 2017 Oct 10;125(10):106002

149.   Strak M, Hoek G, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Janssen NA.Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project. PLoS One. 2013;8(3):e58944. doi: 10.1371/journal.pone.0058944. Epub 2013 Mar 13.

150.   Strak M, Hoek G, Steenhof M, Kilinc E, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Kelly FJ, Harrison RM, Brunekreef B, Lebret E, Janssen NA Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project..Occup Environ Med. 2013 May;70(5):332-40. doi: 10.1136/oemed-2012-100992. Epub 2013 Feb 1.

151.   Strak M, Janssen NA, Godri KJ, Gosens I, Mudway IS, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Hoek G. Respiratory Health Effects of Airborne Particulate Matter: The Role of Particle Size, Composition, and Oxidative Potential-The RAPTES Project.Environ Health Perspect. 2012 Aug;120(8):1183-9.  

152.   Totlandsdal AI, Cassee FR, Schwarze P, Refsnes M, Lag M. Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells. Part Fibre Toxicol. 2010;7:41.

153.   Totlandsdal AI, Låg M, Lilleaas E, Cassee F, Schwarze P Differential proinflammatory responses induced by diesel exhaust particles with ontrasting PAH and metal content.. Environ Toxicol. 2013 Jul 31. doi: 10.1002/tox.21884.  

154.  Ulrich MM, Alink GM, Kumarathasan P, Vincent R, Boere AJ, Cassee FR. Health effects and time course of particulate matter on the cardiopulmonary system in rats with lung inflammation. J Toxicol Environ Health A. 2002 Oct 25;65(20):1571-95.

155.   Valentino, SA, Tarrade, A, Aioun, J, Mourier, E, Richard, C, Dahirel, M, Rousseau-Ralliard, D, Fournier, N, Aubrière, M-C, Lallemand, M-S, Camous, S, Guinot, M, Charlier, M, Aujean, E, Al Adhami, H, Fokkens, PH, Agier, L, Boere, JA, Cassee, FR, Slama, R & Chavatte-Palmer, P 2016, 'Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits' Particle and Fibre Toxicology [E], vol 13, no. 1, pp. 39. DOI: 10.1186/s12989-016-0151-7

156.   van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, et al. Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol. 2010 Jul;84(7):553-62.

157.   van der Gon HA, Gerlofs-Nijland ME, Gehrig R, Gustafsson M, Janssen N, Harrison RM, Hulskotte J, Johansson C, Jozwicka M, Keuken M, Krijgsheld K, Ntziachristos L, Riediker M, Cassee FR The policy relevance of wear emissions from road transport, now and in the future--an international workshop report and consensus statement..J Air Waste Manag Assoc. 2013 Feb;63(2):136-49. Review.

158.   Verma V, Polidori A, Schauer JJ, Shafer MM, Cassee FR, Sioutas C. Physicochemical and toxicological profiles of particulate matter in Los Angeles during the October 2007 southern California wildfires. Environ Sci Technol. 2009 Feb 1;43(3):954-60.

159.   Viana M, Salmatonidis A, Bezantakos S, Ribalta C, Moreno N, Córdoba P, Cassee FR, Boere J, Fraga S, Teixeira JP, Bessa MJ, Monfort E. Characterizing the Chemical Profile of Incidental Ultrafine Particles for Toxicity Assessment Using an Aerosol Concentrator. Ann Work Expo Health. 2021 Oct 9;65(8):966-978. doi: 10.1093/annweh/wxab011. 

160.   Vlaanderen JJ, Janssen NA, Hoek G, Keski-Rahkonen P, Barupal DK, Cassee FR, Gosens I, Strak M, Steenhof M, Lan Q, Brunekreef B, Scalbert A, Vermeulen RC.The impact of ambient air pollution on the human blood metabolome.Environ Res. 2017 Apr 5;156:341-348

161.   Vogel U, Cassee FR Editorial: dose-dependent ZnO particle-induced acute phase response in humans warrants re-evaluation of occupational exposure limits for metal oxides. Part Fibre Toxicol. 2018 Feb 12;15(1):7. doi: 10.1186/s12989-018-0247-3.

162.   Vranic S, Gosens I, Jacobsen NR, Jensen KA, Bokkers B, Kermanizadeh A, Stone V, Baeza-Squiban A, Cassee FR, Tran L, Boland S. Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles. Arch Toxicol. 2017 Jan;91(1):353-363.

163.   Vranic, S, Gosens, I, Jacobsen, NR, Jensen, KA, Bokkers, B, Kermanizadeh, A, Stone, V, Baeza-Squiban, A, Cassee, FR, Tran, L & Boland, S 2016, 'Impact of serum as a dispersion agent for in vitro and in vivo toxicological assessments of TiO2 nanoparticles' Archives of Toxicology. DOI: 10.1007/s00204-016-1673-3

164.   Wessels A, Van Berlo D, Boots AW, Gerloff K, Scherbart AM, Cassee FR, et al. Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles. Nanotoxicology. 2011 Mar;5(1):66-78.

165.   Yang A, Hoek G, Montagne D, Leseman DL, Hellack B, Kuhlbusch TA, Cassee FR, Brunekreef B, Janssen NA. Agreement of central site measurements and land use regression modeled oxidative potential of PM2.5 with personal exposure. Environ Res. 2015 Jul;140:397-404.

166.   Yang A, Wang M, Eeftens M, Beelen R, Dons E, Leseman DL, Brunekreef B, Cassee FR, Janssen NA, Hoek G. Spatial Variation and Land Use Regression Modeling of the Oxidative Potential of Fine Particles. Environ Health Perspect. 2015 Apr 3.

167.   Yang TJ, Elkhuizen PH, Minkema D, Heemsbergen W, van Mourik AM, Cassee J, et al. Clinical factors associated with seroma volume reduction in breast-Conserving Therapy for early-stage breast cancer: a multi-institutional analysis. Int J Radiat Oncol Biol Phys. 2010 Apr;76(5):1325-32.

168.   Yang Y, Xu L, Dekkers S, Zhang LG, Cassee FR, Zuo YY. Aggregation State of Metal-Based Nanomaterials at the Pulmonary Surfactant Film Determines Biophysical Inhibition. Environ Sci Technol. 2018 Aug 7;52(15):8920-8929. doi: 10.1021/acs.est.8b02976.

169.   Yang, A, Janssen, NAH, Brunekreef, B, Cassee, FR, Hoek, G & Gehring, U 2016, 'Children's respiratory health and oxidative potential of PM2.5: the PIAMA birth cohort study' Occupational and Environmental Medicine, vol 73, no. 3, pp. 154-60. DOI: 10.1136/oemed-2015-103175

170.   Yang, A, Jedynska, A, Hellack, B, Rooter, I, Hoek, G, Brunekreef, B, Kuhlbusch, TAJ, Cassee, FR & Janssen, NAH 2014, 'Measurement of the oxidative potential of PM2.5 and its constituents: The effect of extraction solvent and filter type' Atmospheric Environment, vol 83, pp. 35-42., 10.1016/j.atmosenv.2013.10.049. 

171.   Yokel, RA, Hussain, S, Garantziotis, S, Demokritou, P, Castranova, V & Cassee, FR 2014, 'The Yin: : An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity' Environmental science. Nano, vol 1, no. 5, pp. 406-428., 10.1039/C4EN00039K

172.   Zhang Y, Meliefste K, Hu W, Li J, Xu J, Ning B, Yang K, Chen Y, Liu D, Wong J, Rahman M, Rothman N, Huang Y, Cassee F, Vermeulen R, Lan Q, Downward GS. Household air pollution from, and fuel efficiency of, different coal types following local cooking practices in Xuanwei, China. Environ Pollut. 2021 Dec 1;290:117949. doi: 10.1016/j.envpol.2021.117949. Epub 2021 Aug 12.

BOOK contributions

·         F.R. Cassee, J. Sühnel, J.P. Groten and V.J. Feron, Toxicology of chemical mixtures (Second ed.) In: B. Ballantyne, T. Marrs and T. Syversen, Editors, General and Applied Toxicology vol. 1, Macmillan Reference Ltd., London (1999), pp. 303–319.

·         J.P. Groten, F.R. Cassee, P.J. van Bladeren, C. DeRosa and V.J. Feron, Mixtures In: H. Marquardt, S.G. Schäfer, R. McClellan and F. Welsch, Editors, Toxicology, Academic Press, San Diego (1999), pp. 257–270.

·         Cardiovascular Effects of Inhaled Fine and Nano-sized Particles, Edited by FR Cassee, NL Mills and DE Newby, 1st  Edition - January 2011. 2011. 586 Pages, ISBN-13: 978-0-470-43353-9 - John Wiley & Sons

·         Anique Driessen, Björn Crüts,  Ludo van Etten, Anica Crüts , Paul Fokkens, Flemming Cassee, and Paul J.A. Borm. Short term exposure to nanoparticle-rich diesel engine exhaust causes changes in brain activity but not in cognitive performance in human volunteers .In: Nanoformulation (Tiddy, GJT & Tan, BH, eds), pp 243-255. RSC Publishing, Cambridge, UK, 2012. ISBN: 978-1-84973-524-7

·         F.R. Cassee and V. Castranova - Pulmonary and Cardiovascular Toxicity of Nanomaterials. In: Handbook of Safety Assessment of Nanomaterials: From Toxicological Testing to Personalized Medicine (Ed. Bengt Fadeel) December 10, 2014 by Pan Stanford ISBN 9789814463362 

·         Cassee FR, Kreyling W, Aitken R, Poland C (2015) Dosimetry and toxicology of nanosized particles and fibres. Hdb Env Chem. doi: 10.1007/698_2015_415 

Laurent Gaté, Frédéric Cosnier, Flemming R. Cassee. Rodent Inhalation Studies in Nanotoxicology.Biomedical Application of Nanoparticles. Ed: Bertrand Rihn. CRC presss, ISBN 9781498750011.
Ali Kermanizadeh, Flemming R. Cassee, Wim de Jong. The Potential Adverse Effects of Engineered Nanomaterial Exposure to Human Health Following Pulmonary, Oral and Dermal Exposure Pages 41-58 in: Nanotoxicology in Humans and the Environment 14 Dec.2021by Jamie R. Lead (Editor), Shareen H. Doak (Editor), Martin J.D. Clift (Editor) ISBN : 978-3-030-79807-9