Publicaties
2022
Wetenschappelijke publicaties
Mensink, M., Tran, T. N. M., Zaal, E. A., Schrama, E., Berkers, C. R., Borst, J., & de Kivit, S. (2022). TNFR2 Costimulation Differentially Impacts Regulatory and Conventional CD4+ T-Cell Metabolism. Frontiers in Immunology, 13, [881166]. https://doi.org/10.3389/fimmu.2022.881166
González-García, P., Díaz-Casado, M. E., Hidalgo-Gutiérrez, A., Jiménez-Sánchez, L., Bakkali, M., Barriocanal-Casado, E., Escames, G., Chiozzi, R. Z., Völlmy, F., Zaal, E. A., Berkers, C. R., Heck, A. J. R., & López, L. C. (2022). The Q-junction and the inflammatory response are critical pathological and therapeutic factors in CoQ deficiency. Redox Biology, 55, [102403]. https://doi.org/10.1016/j.redox.2022.102403
Peeters, R., Cuenca-Escalona, J., Zaal, E. A., Hoekstra, A. T., Balvert, A. C. G., Vidal-Manrique, M., Blomberg, N., van Deventer, S. J., Stienstra, R., Jellusova, J., Giera, M., Hannibal, L., Spiekerkoetter, U., ter Beest, M., Berkers, C. R., & van Spriel, A. B. (2022). Fatty acid metabolism in aggressive B-cell lymphoma is inhibited by tetraspanin CD37. Nature Communications, 13(1), 1-18. [5371]. https://doi.org/10.1038/s41467-022-33138-7
Van Nyen, T., Planque, M., van Wagensveld, L., Duarte, J. A. G., Zaal, E. A., Talebi, A., Rossi, M., Körner, P. R., Rizzotto, L., Moens, S., De Wispelaere, W., Baiden-Amissah, R. E. M., Sonke, G. S., Horlings, H. M., Eelen, G., Berardi, E., Swinnen, J. V., Berkers, C. R., Carmeliet, P., ... Amant, F. (2022). Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers. Nature Communications, 13(1), 1-19. [4578]. https://doi.org/10.1038/s41467-022-32272-6
Zaal, E. A., de Grooth, H-J., Oudaert, I., Langerhorst, P., Levantovsky, S., van Slobbe, G. J. J., Jansen, J. W. A., Menu, E., Wu, W., & Berkers, C. R. (2022). Targeting coenzyme Q10 synthesis overcomes bortezomib resistance in multiple myeloma. Molecular Omics, 18(1), 19-30. https://doi.org/10.1039/d1mo00106j
2021
Wetenschappelijke publicaties
Besse, L., Besse, A., Stolze, S. C., Sobh, A., Zaal, E. A., Ham, A. J. V. D., Ruiz, M., Phuyal, S., Buchler, L., Sathianathan, M., Florea, B. I., Boren, J., Hlman, M. S., Huber, J., Bolomsky, A., Ludwig, H., Hannich, J. T., Loguinov, A., Everts, B., ... Driessen, C. (2021). Treatment with HIV-protease inhibitor nelfinavir identifies membrane lipid composition and fluidity as a therapeutic target in advanced multiple myeloma. Cancer Research, 81(17), 4581-4593. https://doi.org/10.1158/0008-5472.CAN-20-3323
Champagne, J., Pataskar, A., Blommaert, N., Nagel, R., Wernaart, D., Ramalho, S., Kenski, J., Bleijerveld, O. B., Zaal, E. A., Berkers, C. R., Altelaar, M., Peeper, D. S., Faller, W. J., & Agami, R. (2021). Oncogene-dependent sloppiness in mRNA translation. Molecular Cell, 81(22), 4709-4721. https://doi.org/10.1016/j.molcel.2021.09.002
Chen, J., Zaal, E. A., Berkers, C. R., Ruijtenbeek, R., Garssen, J., & Redegeld, F. A. (2021). Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation. Cells, 10(9), [2287]. https://doi.org/10.3390/cells10092287
Jamalpoor, A., van Gelder, C. A. G. H., Yousef Yengej, F. A., Zaal, E. A., Berlingerio, S. P., Veys, K. R., Pou Casellas, C., Voskuil, K., Essa, K., Ammerlaan, C. M. E., Rega, L. R., van der Welle, R. E. N., Lilien, M. R., Rookmaaker, M. B., Clevers, H., Klumperman, J., Levtchenko, E., Berkers, C. R., Verhaar, M. C., ... Janssen, M. J. (2021). Cysteamine–bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis. EMBO Molecular Medicine, 13(7), 1-20. [e13067]. https://doi.org/10.15252/emmm.202013067
Ghanem, A., Melzer, A. M., Zaal, E., Neises, L., Baltissen, D., Matar, O., Glennemeier-Marke, H., Almouhanna, F., Theobald, J., Abu El Maaty, M. A., Berkers, C., & Wölfl, S. (2021). Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis. Free Radical Biology and Medicine, 163, 196-209. https://doi.org/10.1016/j.freeradbiomed.2020.12.012
Bartok, O., Pataskar, A., Nagel, R., Laos, M., Goldfarb, E., Hayoun, D., Levy, R., Körner, P-R., Kreuger, I. Z. M., Champagne, J., Zaal, E. A., Bleijerveld, O. B., Huang, X., Kenski, J., Wargo, J., Brandis, A., Levin, Y., Mizrahi, O., Alon, M., ... Agami, R. (2021). Anti-tumour immunity induces aberrant peptide presentation in melanoma. Nature, 590(7845), 332–337. https://doi.org/10.1038/s41586-020-03054-1
2020
Wetenschappelijke publicaties
Jamalpoor, A., van Gelder, C. A. G. H., Yousef Yengej, F. A., Zaal, E. A., Berlingerio, S. P., Veys, K. R., Pou Casellas, C., Voskuil, K., Essa, K., Ammerlaan, C., Rega, L. R., van der Welle, R., Lilien, M. R., Rookmaaker, M. B., Clevers, H. C., Klumperman, J., Levtchenko, E., Berkers, C. R., Verhaar, M. C., ... Janssen, M. J. (2020). Cysteamine-bicalutamide combination treatment restores alpha-ketoglutarate and corrects proximal tubule phenotype in cystinosis. (pp. 1-53). bioRxiv. https://doi.org/10.1101/2020.02.10.941799
Jin, H., Wang, S., Zaal, E. A., Wang, C., Wu, H., Bosma, A., Jochems, F., Isima, N., Jin, G., Lieftink, C., Beijersbergen, R., Berkers, C. R., Qin, W., & Bernards, R. (2020). A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer. eLife, 9, [e56749]. https://doi.org/10.7554/eLife.56749
2019
Wetenschappelijke publicaties
Milne, K., Sun, J., Zaal, E. A., Mowat, J., Celie, P. H. N., Fish, A., Berkers, C. R., Forlani, G., Loayza-Puch, F., Jamieson, C., & Agami, R. (2019). A fragment-like approach to PYCR1 inhibition. Bioorganic and Medicinal Chemistry Letters, 29(18), 2626-2631. https://doi.org/10.1016/j.bmcl.2019.07.047
Sun, J., Nagel, R., Zaal, E. A., Ugalde, A. P., Han, R., Proost, N., Song, J. Y., Pataskar, A., Burylo, A., Fu, H., Poelarends, G. J., van de Ven, M., van Tellingen, O., Berkers, C. R., & Agami, R. (2019). SLC1A3 contributes to L-asparaginase resistance in solid tumors. EMBO Journal, 38(21), [e102147]. https://doi.org/10.15252/embj.2019102147
Jansen, J., Jansen, K., Neven, E., Poesen, R., Othman, A., van Mil, A., Sluijter, J., Sastre Torano, J., Zaal, E. A., Berkers, C. R., Esser, D., Wichers, H. J., van Ede, K., van Duursen, M., Burtey, S., Verhaar, M. C., Meijers, B., & Masereeuw, R. (2019). Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion. Proceedings of the National Academy of Sciences of the United States of America, 116(32), 16105-16110. https://doi.org/10.1073/pnas.1821809116
2018
Wetenschappelijke publicaties
Zaal, E. A., & Berkers, C. R. (2018). The Influence of Metabolism on Drug Response in Cancer. Frontiers in Oncology, 8, [500]. https://doi.org/10.3389/fonc.2018.00500
Zaal, E. A. (2018). Exploring the role of cellular metabolism in anticancer drug resistance: a metabolomics approach. [Doctoral thesis 1 (Research UU / Graduation UU), Universiteit Utrecht]. Utrecht University.
https://dspace.library.uu.nl/bitstream/handle/1874/364285/Zaal.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/364285/Zaal.pdf?sequence=1
Wu, W., Zaal, E. A., Berkers, C. R., Lemeer, S., & Heck, A. J. R. (2018). CTGF/VEGFA-activated fibroblasts promote tumor migration through micro-environmental modulation. Molecular and Cellular Proteomics, 17(8), 1502-1514. https://doi.org/10.1074/mcp.RA118.000708
2017
Wetenschappelijke publicaties
Wisse, L. E., Penning, R., Zaal, E. A., van Berkel, C. G. M., ter Braak, T. J., Polder, E., Kenney, J. W., Proud, C. G., Berkers, C. R., Altelaar, M. A. F., Speijer, D., van der Knaap, M. S., & Abbink, T. E. M. (2017). Proteomic and metabolomic analyses of vanishing white matter mouse astrocytes reveal deregulation of ER functions. Frontiers in Cellular Neuroscience, 11, [411]. https://doi.org/10.3389/fncel.2017.00411
Zaal, E. A., Wu, W., Jansen, G., Zweegman, S., Cloos, J., & Berkers, C. R. (2017). Bortezomib resistance in multiple myeloma is associated with increased serine synthesis. Cancer & metabolism, 5, [7]. https://doi.org/10.1186/s40170-017-0169-9
Loayza-Puch, F., Rooijers, K., Zijlstra, J. S., Moumbeini, B., Zaal, E. A., Oude Vrielink, J. F., Lopes, R. M., Ugalde, A. P., Berkers, C. R., & Agami, R. (2017). TGFβ1-induced leucine limitation uncovered by differential ribosome codon reading. EMBO Reports, 18(4), 549-557. https://doi.org/10.15252/embr.201744000
Ruprecht, B., Zaal, E. A., Zecha, J., Wu, W., Berkers, C. R., Kuster, B., & Lemeer, S. (2017). Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis. Cancer Research, 77(8), 1842-1853. https://doi.org/10.1158/0008-5472.CAN-16-2976
Leestemaker, Y., de Jong, A., Witting, K. F., Penning, R., Schuurman, K., Rodenko, B., Zaal, E. A., van de Kooij, B., Laufer, S., Heck, A. J. R., Borst, J., Scheper, W., Berkers, C. R., & Ovaa, H. (2017). Proteasome Activation by Small Molecules. Cell Chemical Biology, 24(6), 725-736.e7. https://doi.org/10.1016/j.chembiol.2017.05.010
2016
Wetenschappelijke publicaties
Becher, I., Werner, T., Doce, C., Zaal, E. A., Tögel, I., Khan, C. A., Rueger, A., Muelbaier, M., Salzer, E., Berkers, C. R., Fitzpatrick, P. F., Bantscheff, M., & Savitski, M. M. (2016). Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat. Nature Chemical Biology, 12(11), 908-910. https://doi.org/10.1038/nchembio.2185
Weijer, R., Clavier, S., Zaal, E. A., Pijls, M. M. E., van Kooten, R. T., Vermaas, K., Leen, R., Jongejan, A., Moerland, P. D., van Kampen, A. H. C., van Kuilenburg, A. B. P., Berkers, C. R., Lemeer, S., & Heger, M. (2016). Multi-OMIC profiling of survival and metabolic signaling networks in cells subjected to photodynamic therapy. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-016-2401-0
Liu, Y., Garcia Lopes Maia Rodrigues, J., Bonvin, A. M. J. J., Zaal, E. A., Berkers, C. R., Heger, M., Gawarecka, K., Swiezewska, E., Breukink, E., & Egmond, M. R. (2016). New insight into the catalytic mechanism of bacterial mray from enzyme kinetics and docking studies. Journal of Biological Chemistry, 291(29), 15057-15068. https://doi.org/10.1074/jbc.M116.717884