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Prof. dr. A. (Alain) de Bruin

Hoogleraar 
Diergeneeskunde
Departement Biomolecular Health Sciences
Celbiologie, Metabolisme & Kanker
Pathobiologie
Pathobiologie
Androclusgebouw
Yalelaan 1
Kamer O167
3584 CL Utrecht

Prof. dr. A. (Alain) de Bruin

Hoogleraar
Pathobiologie
030 253 4293
a.debruin@uu.nl
Profiel CV Publicaties Onderzoek Onderwijs Nevenwerkzaamheden Contact
Profiel CV Publicaties Onderzoek Onderwijs Nevenwerkzaamheden Contact
Expertises
Vaardigheden
Onderzoeksthema's

Sleutelpublicaties

Tsai, S. Y., Opavsky, R., Sharma, N., Wu, L., Naidu, S., Nolan, E., Feria-Arias, E., Timmers, C., Opavska, J., de Bruin, A., Chong, J., Trikha, P., Fernandez, S., Stromberg, P., Rosol, T. J., & Leone, G. (2008). Mouse development with a single E2F activator. Nature, 454, 1137-1141.
https://dspace.library.uu.nl/bitstream/handle/1874/32202/Tsai%2520et%2520al%25202008.pdf?sequence=1
Yuan, R., Vos, H., van Es, R. M., Chen, J., Burgering, B. M. T., Westendorp, B., & de Bruin, A. (2018). Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest. EMBO Journal, 37(5), [e97877]. https://doi.org/10.15252/embj.201797877
Maiti, B., Li, J., de Bruin, A., Gordon, F., Timmers, C., Opavsky, R., Patil, K., Tuttle, J., Cleghorn, W., & Leone, G. (2005). Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. Journal of Biological Chemistry, 280(18), 18211-20. https://doi.org/10.1074/jbc.M501410200
Moreno, E., Toussaint, M. J. M., van Essen, S. C., Bongiovanni, L., van Liere, E. A., Koster, M. H., Yuan, R., van Deursen, J., Westendorp, B., & de Bruin, A. (2021). E2F7 is a potent inhibitor of liver tumor growth in adult mice. Hepatology, 73(1), 303-317. https://doi.org/10.1002/hep.31259
Demaria, M., Ohtani, N., Youssef Hassan, S., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., Hoeijmakers, J. H. J., de Bruin, A., Hara, E., & Campisi, J. (2014). An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA. Developmental Cell, 31(6), 722-33. https://doi.org/10.1016/j.devcel.2014.11.012
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., Alston, S., Academia, E. C., Kilmarx, S., Valdovinos, A., Wang, B., de Bruin, A., Kennedy, B. K., Melov, S., Zhou, D., ... Campisi, J. (2017). Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery, 7(2), 165-176. https://doi.org/10.1158/2159-8290.CD-16-0241
Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., Youssef, S. A., Kuiper, R. V., Nagarajah, B., van Oostrom, C. T., Brandt, R. M. C., Barnhoorn, S., Imholz, S., Pennings, J. L. A., de Bruin, A., ... Hoeijmakers, J. H. J. (2016). Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature, 537, 427-431. https://doi.org/10.1038/nature19329
Kent, L. N., Bae, S., Tsai, S. Y., Tang, X., Srivastava, A., Koivisto, C., Martin, C. K., Ridolfi, E., Miller, G. C., Zorko, S. M., Plevris, E., Hadjiyannis, Y., Perez, M., Nolan, E., Kladney, R., Westendorp, B., De Bruin, A., Fernandez, S., Rosol, T. J., ... Leone, G. (2017). Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. Journal of Clinical Investigation, 127(3), 830-842. https://doi.org/10.1172/JCI87583
Thurlings, I., Martínez-López, L. M., Westendorp, B., Zijp, M., Kuiper, R., Tooten, P., Kent, L. N., Leone, G., Vos, H. J., Burgering, B., & de Bruin, A. (2017). Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. Oncogene, 36, 829-839. https://doi.org/10.1038/onc.2016.251
Pandit, S. K., Westendorp, B., Nantasanti, S., van Liere, E., Tooten, P. C. J., Cornelissen, P. W. A., Toussaint, M. J. M., Lamers, W. H., & de Bruin, A. (2012). E2F8 is essential for polyploidization in mammalian cells. Nature Cell Biology, 14(11), 1181-1191. https://doi.org/10.1038/ncb2585
Pedone, E., Olteanu, V-A., Marucci, L., Muñoz-Martin, M. I., Youssef, S. A., de Bruin, A., & Cosma, M. P. (2017). Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration. Cell Reports, 18(1), 107-121. https://doi.org/10.1016/j.celrep.2016.12.008
Weijts, B. G. M. W., Bakker, W. J., Cornelissen, P. W. A., Liang, K. A., Schaftenaar, F. A., Westendorp, B., Wolf, C. A., Paciejewska, M., Scheele, C. L., Kent, L., Leone, G., Schulte-Merker, S., & de Bruin, A. (2012). E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO Journal, 19, 3871-3884. https://doi.org/10.1038/emboj.2012.231
Li, J., Ran, C., Li, E., Gordon, F., Comstock, G., Siddiqui, H., Cleghorn, W., Chen, H., Kornacker, K., Pandit, S. K., Khanizadeh, M., Weinstein, M., Leone, G., & de Bruin, A. (2008). Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Developmental Cell, 14, 62-75.
https://dspace.library.uu.nl/bitstream/handle/1874/32199/Li%2520et%2520al%25202008.pdf?sequence=1
Wu, L., de Bruin, A., Saavedra, H. I., Starovic, M., Trimboli, A., Yang, Y., Opavska, J., Wilson, P., Thompson, J. C., Ostrowski, M. C., Rosol, T. J., Woollett, L. A., Weinstein, M., Cross, J. C., Robinson, M. L., & Leone, G. (2003). Extra-embryonic function of Rb is essential for embryonic development and viability. Nature, 421(6926), 942-7. https://doi.org/10.1038/nature01417
de Bruin, A., Maiti, B., Jakoi, L., Timmers, C., Buerki, R., & Leone, G. (2003). Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. Journal of Biological Chemistry, 278(43), 42041-9. https://doi.org/10.1074/jbc.M308105200
Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H. Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., Koivisto, C., Martin, C. K., Cuitino, M. C., Perez, M., Clouse, J. M., Chokshi, V., Shinde, N., Kladney, R., Sun, D., ... Leone, G. (2016). E2f8 mediates tumor suppression in postnatal liver development. Journal of Clinical Investigation, 126(8), 2955-2969. https://doi.org/10.1172/JCI85506
Yuan, R., Liu, Q., Segeren, H. A., Yuniati, L., Guardavaccaro, D., Lebbink, R. J., Westendorp, B., & de Bruin, A. (2019). Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression. EMBO Journal, 38, [e101430]. https://doi.org/10.15252/embj.2018101430

Publicaties

2023

Wetenschappelijke publicaties

Lyraki, R., Grabek, A., Tison, A., Weerasinghe-Arachchige, L-C., Peitzsch, M., Bechman, N., Youssef, S. A., de Bruin, A., Bakker, E. R. M., Claessens, F., Chaboissier, M-C., & Schedl, A. (2023). Adrenal cortex size and homeostasis are regulated by gonadal hormones via androgen receptor/β-catenin signaling crosstalk. Disease Models & Mechanisms. https://doi.org/10.1242/dmm.050053
Stroo, E., Janssen, L., Sin, O., Hogewerf, W., Koster, M., Harkema, L., Youssef, S. A., Beschorner, N., Wolters, A. H., Bakker, B., Becker, L., Garrett, L., Marschall, S., Hoelter, S. M., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Thathiah, A., ... Nollen, E. A. (2023). Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain. Life Science Alliance, 6(7). https://doi.org/10.26508/lsa.202201730
Tol, A. J. C., Hribar, K., Kruit, J., Bongiovanni, L., Vieira-Lara, M. A., Koster, M. H., Kloosterhuis, N. J., Havinga, R., Koehorst, M., de Bruin, A., Bakker, B. M., Oosterveer, M. H., & van der Beek, E. M. (2023). Hyperglycaemia, pregnancy outcomes and maternal metabolic disease risk during pregnancy and lactation in a lean gestational diabetes mouse model. Journal of Physiology. https://doi.org/10.1113/JP284061
Lak, N. S. M., Seijger, A., van Zogchel, L. M. J., Gelineau, N. U., Javadi, A., Zappeij-Kannegieter, L., Bongiovanni, L., Andriessen, A., Stutterheim, J., van der Schoot, C. E., de Bruin, A., & Tytgat, G. A. M. (2023). Cell-Free RNA from Plasma in Patients with Neuroblastoma: Exploring the Technical and Clinical Potential. Cancers, 15(7), 1-16. [2108]. https://doi.org/10.3390/cancers15072108
Rutten, M. G. S., Lei, Y., Hoogerland, J. H., Bloks, V. W., Yang, H., Bos, T., Krishnamurthy, K. A., Bleeker, A., Koster, M. H., Thomas, R. E., Wolters, J. C., van den Bos, H., Mithieux, G., Rajas, F., Mardinoglu, A., Spierings, D. C. J., de Bruin, A., van de Sluis, B., & Oosterveer, M. H. (2023). Normalization of hepatic ChREBP activity does not protect against liver disease progression in a mouse model for Glycogen Storage Disease type Ia. Cancer & metabolism, 11(1), 1-11. [5]. https://doi.org/10.1186/s40170-023-00305-3

2022

Wetenschappelijke publicaties

Moreno, E., Matondo, A. B., Bongiovanni, L., van de Lest, C. H. A., Molenaar, M. R., Toussaint, M. J. M., van Essen, S. C., Houweling, M., Helms, J. B., Westendorp, B., & de Bruin, A. (2022). Inhibition of polyploidization in Pten-deficient livers reduces steatosis. Liver International, 42(11), 2442-2452. https://doi.org/10.1111/liv.15384
Bazioti, V., La Rose, A. M., Maassen, S., Bianchi, F., de Boer, R., Halmos, B., Dabral, D., Guilbaud, E., Flohr-Svendsen, A., Groenen, A. G., Marmolejo-Garza, A., Koster, M. H., Kloosterhuis, N. J., Havinga, R., Pranger, A. T., Langelaar-Makkinje, M., de Bruin, A., van de Sluis, B., Kohan, A. B., ... Westerterp, M. (2022). T cell cholesterol efflux suppresses apoptosis and senescence and increases atherosclerosis in middle aged mice. Nature Communications, 13(1), 1-23. [3799]. https://doi.org/10.1038/s41467-022-31135-4
Vriend, L., van Dongen, J., Sinkunas, V., Brouwer, L., Buikema, H., Moreira, L., Gemperli, R., Bongiovanni, L., de Bruin, A., van der Lei, B., Camargo, C., & Harmsen, M. C. (2022). Limited efficacy of adipose stromal cell secretome-loaded skin-derived hydrogels to augment skin flap regeneration in rats. Stem Cells and Development, 31(19-20), 630-640. https://doi.org/10.1089/scd.2022.0003
Segeren, H. A., van Liere, E. A., Riemers, F. M., de Bruin, A., & Westendorp, B. (2022). Oncogenic RAS sensitizes cells to drug-induced replication stress via transcriptional silencing of P53. Oncogene, 41(19), 2719-2733. https://doi.org/10.1038/s41388-022-02291-0

2021

Wetenschappelijke publicaties

Joshi, B. S., Youssef, S. A., Bron, R., de Bruin, A., Kampinga, H. H., & Zuhorn, I. S. (2021). DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease. iScience, 24(11), 1-18. [103282]. https://doi.org/10.1016/j.isci.2021.103282
Johanna, I., Hernández-López, P., Heijhuurs, S., Scheper, W., Bongiovanni, L., de Bruin, A., Beringer, D. X., Oostvogels, R., Straetemans, T., Sebestyen, Z., & Kuball, J. (2021). Adding Help to an HLA-A*24:02 Tumor-Reactive γδTCR Increases Tumor Control. Frontiers in Immunology, 12, 1-12. [752699]. https://doi.org/10.3389/fimmu.2021.752699
Andriessen, A., Bongiovanni, L., Driedonks, T. A. P., van Liere, E., Seijger, A., Hegeman, C. V., van Nimwegen, S. A., Galac, S., Westendorp, B., Nolte-T Hoen, E. N. M., & de Bruin, A. (2021). CDC6: A novel canine tumour biomarker detected in circulating extracellular vesicles. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12781
Heida, A., Gruben, N., Catrysse, L., Koehorst, M., Koster, M., Kloosterhuis, N. J., Gerding, A., Havinga, R., Bloks, V. W., Bongiovanni, L., Wolters, J. C., van Dijk, T., van Loo, G., de Bruin, A., Kuipers, F., Koonen, D. P. Y., & van de Sluis, B. (2021). The hepatocyte IKK:NF-κB axis promotes liver steatosis by stimulating de novo lipogenesis and cholesterol synthesis. Molecular Metabolism, 54, 1-14. [101349]. https://doi.org/10.1016/j.molmet.2021.101349
Roukens, M. G., Frederiks, C. L., Seinstra, D., Braccioli, L., Khalil, A. A., Pals, C., De Neck, S., Bornes, L., Beerling, E., Mokry, M., de Bruin, A., Westendorp, B., van Rheenen, J., & Coffer, P. J. (2021). Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation. Oncogene, 40(45), 6343-6353. https://doi.org/10.1038/s41388-021-02004-z
Schukken, K. M., Zhu, Y., Bakker, P. L., Koster, M. H., Harkema, L., Youssef, S. A., de Bruin, A., & Foijer, F. (2021). Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice. Scientific Reports, 11(1), [68]. https://doi.org/10.1038/s41598-020-80169-5
Ijssennagger, N., van Rooijen, K. S., Magnúsdóttir, S., Ramos Pittol, J. M., Willemsen, E. C. L., de Zoete, M. R., Baars, M. J. D., Stege, P. B., Colliva, C., Pellicciari, R., Youssef, S. A., de Bruin, A., Vercoulen, Y., Kuipers, F., & van Mil, S. W. C. (2021). Ablation of liver Fxr results in an increased colonic mucus barrier in mice. JHEP Reports, 3(5), 100344. [100344]. https://doi.org/10.1016/j.jhepr.2021.100344
Bongiovanni, L., Andriessen, A., Silvestri, S., Porcellato, I., Brachelente, C., & de Bruin, A. (2021). H2AFZ: A Novel Prognostic Marker in Canine Melanoma and a Predictive Marker for Resistance to CDK4/6 Inhibitor Treatment. Frontiers in Veterinary Science, 8, 1-15. [705359]. https://doi.org/10.3389/fvets.2021.705359
Rutten, M. G. S., Derks, T. G. J., Huijkman, N. C. A., Bos, T., Kloosterhuis, N. J., van de Kolk, K. C. W. A., Wolters, J. C., Koster, M. H., Bongiovanni, L., Thomas, R. E., de Bruin, A., van de Sluis, B., & Oosterveer, M. H. (2021). Modeling Phenotypic Heterogeneity of Glycogen Storage Disease Type 1a Liver Disease in Mice by Somatic CRISPR/CRISPR-associated protein 9–Mediated Gene Editing. Hepatology, 74(5), 2491-2507. https://doi.org/10.1002/hep.32022
Riedlinger, T., Dommerholt, M. B., Wijshake, T., Kruit, J. K., Huijkman, N., Dekker, D., Koster, M., Kloosterhuis, N., Koonen, D. P. Y., de Bruin, A., Baker, D., Hofker, M. H., van Deursen, J., Jonker, J. W., Lienhard Schmitz, M., & van de Sluis, B. (2021). Corrigendum to “NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation” [Biochim. Biophys. Acta Mol. Cell Res., 1864 (2017): 1785–1798]. Biochimica et Biophysica Acta - Molecular Cell Research, 1868(6), [119008]. https://doi.org/10.1016/j.bbamcr.2021.119008
Moreno, E., Pandit, S. K., Toussaint, M. J. M., Bongiovanni, L., Harkema, L., van Essen, S. C., van Liere, E. A., Westendorp, B., & de Bruin, A. (2021). Atypical E2Fs either Counteract or Cooperate with RB during Tumorigenesis Depending on Tissue Context. Cancers, 13(9), 1-14. [2033]. https://doi.org/10.3390/cancers13092033
Bongiovanni, L., Andriessen, A., Wauben, M. H. M., Hoen, E. N. M. N., & de Bruin, A. (2021). Extracellular Vesicles: Novel Opportunities to Understand and Detect Neoplastic Diseases. Veterinary Pathology, 58(3), 453-471. https://doi.org/10.1177/0300985821999328
Moreno, E., Toussaint, M. J. M., van Essen, S. C., Bongiovanni, L., van Liere, E. A., Koster, M. H., Yuan, R., van Deursen, J., Westendorp, B., & de Bruin, A. (2021). E2F7 is a potent inhibitor of liver tumor growth in adult mice. Hepatology, 73(1), 303-317. https://doi.org/10.1002/hep.31259

2020

Wetenschappelijke publicaties

Segeren, H. A., van Rijnberk, L. M., Moreno, E., Riemers, F. M., van Liere, E. A., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell-Cycle Exit after DNA Damage. Cell Reports, 33(9), [108449]. https://doi.org/10.1016/j.celrep.2020.108449
Sladky, V. C., Knapp, K., Szabo, T. G., Braun, V. Z., Bongiovanni, L., van den Bos, H., Spierings, D. C. J., Westendorp, B., Curinha, A., Stojakovic, T., Scharnagl, H., Timelthaler, G., Tsuchia, K., Pinter, M., Semmler, G., Foijer, F., de Bruin, A., Reiberger, T., Rohr-Udilova, N., & Villunger, A. (2020). PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis. EMBO Reports, 21, 1-16. [e50893]. https://doi.org/10.15252/embr.202050893
Ronda, O. A. H. O., van de Heijning, B. J. M., de Bruin, A., Thomas, R. E., Martini, I., Koehorst, M., Gerding, A., Koster, M. H., Bloks, V. W., Jurdzinski, A., Mulder, N. L., Havinga, R., van der Beek, E. M., Reijngoud, D-J., Kuipers, F., & Verkade, H. J. (2020). Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet. PLoS One, 15(9), [e0232069]. https://doi.org/10.1371/journal.pone.0232069
van de Peppel, I. P., Rao, A., Dommerholt, M. B., Bongiovanni, L., Thomas, R., de Bruin, A., Karpen, S. J., Dawson, P. A., Verkade, H. J., & Jonker, J. W. (2020). The Beneficial Effects of Apical Sodium-Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition. Molecular Nutrition & Food Research, 64(24), [2000750]. https://doi.org/10.1002/mnfr.202000750
Saeed, A., Bartuzi, P., Heegsma, J., Dekker, D., Kloosterhuis, N., de Bruin, A., Jonker, J. W., van de Sluis, B., & Faber, K. N. (Accepted/In press). Impaired Hepatic Vitamin A Metabolism in NAFLD Mice Leading to Vitamin A Accumulation in Hepatocytes. Cellular and Molecular Gastroenterology and Hepatology. https://doi.org/10.1016/j.jcmgh.2020.07.006
Segeren, H. A., van Rijnberk, L., Moreno, E., Riemers, F., Yuan, R., Wubbolts, R., de Bruin, A., & Westendorp, B. (2020). Excessive E2F Transcription in Single Cancer Cells Precludes Transient Cell Cycle Exit after DNA Damage. SSRN Electronic Journal. https://doi.org/10.2139/ssrn.3570558
Drescher, H. K., Schippers, A., Rosenhain, S., Gremse, F., Bongiovanni, L., Bruin, A. D., Eswaran, S., Gallage, S. U., Pfister, D., Szydlowska, M., Heikenwalder, M., Weiskirchen, S., Wagner, N., Trautwein, C., Weiskirchen, R., & Kroy, D. C. (2020). L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men. Cells, 9(5), [1106]. https://doi.org/10.3390/cells9051106
Richardson, N., Gillot, I., Gregoire, E. P., Youssef, S. A., de Rooij, D., de Bruin, A., De Cian, M-C., & Chaboissier, M-C. (2020). Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversals. eLife, 9, [e53972]. https://doi.org/10.7554/eLife.53972
Cubero, F. J., Mohamed, M. R., Woitok, M. M., Zhao, G., Hatting, M., Nevzorova, Y. A., Chen, C., Haybaeck, J., de Bruin, A., Avila, M. A., Boekschoten, M. V., Davis, R. J., & Trautwein, C. (2020). Loss of c-Jun N-terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma. Hepatology Communications, 4(6), 834-851. https://doi.org/10.1002/hep4.1495
Verboom, L., Martens, A., Priem, D., Hoste, E., Sze, M., Vikkula, H., Van Hove, L., Voet, S., Roels, J., Maelfait, J., Bongiovanni, L., de Bruin, A., Scott, C. L., Saeys, Y., Pasparakis, M., Bertrand, M. J. M., & van Loo, G. (2020). OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis. Cell Reports, 30(7), 2237–2247.e1–e6. https://doi.org/10.1016/j.celrep.2020.01.028
Lei, Y., Hoogerland, J. A., Bloks, V. W., Bos, T., Bleeker, A., Wolters, H., Wolters, J. C., Hijmans, B. S., van Dijk, T. H., Thomas, R., van Weeghel, M., Mithieux, G., Houtkooper, R. H., de Bruin, A., Rajas, F., Kuipers, F., & Oosterveer, M. H. (2020). Hepatic ChREBP activation limits NAFLD development in a mouse model for Glycogen Storage Disease type Ia. Hepatology. https://doi.org/10.1002/hep.31198
Bautista-Niño, P. K., Portilla-Fernandez, E., Rubio-Beltrán, E., van der Linden, J. J., de Vries, R., van Veghel, R., de Boer, M., Durik, M., Ridwan, Y., Brandt, R. M. C., Essers, J., Menzies, R. I., Thomas, R., de Bruin, A., Duncker, D. J., van Beusekom, H. M. M., Ghanbari, M., Hoeijmakers, J. H. J., Sedlacek, R., ... Roks, A. J. M. (2020). Local endothelial dna repair defect causes aging-resembling endothelial-specific dysfunction. Clinical Science, 134(7), 727–746. https://doi.org/10.1042/CS20190124
Sladky, V. C., Knapp, K., Soratroi, C., Heppke, J., Eichin, F., Rocamora-Reverte, L., Szabo, T. G., Bongiovanni, L., Westendorp, B., Moreno, E., van Liere, E. A., Bakker, B., Spierings, D. C. J., Wardenaar, R., Pereyra, D., Starlinger, P., Schultze, S., Trauner, M., Stojakovic, T., ... Villunger, A. (2020). E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration. Developmental Cell, 52(3), 335-349.e7. https://doi.org/10.1016/j.devcel.2019.12.016
Johanna, I., Hernández-López, P., Heijhuurs, S., Bongiovanni, L., de Bruin, A., Beringer, D., van Dooremalen, S., Shultz, L. D., Ishikawa, F., Sebestyen, Z., Straetemans, T., & Kuball, J. (2020). TEG011 persistence averts extramedullary tumor growth without exerting off-target toxicity against healthy tissues in a humanized HLA-A*24:02 transgenic mice. Journal of Leukocyte Biology. https://doi.org/10.1002/JLB.5MA0120-228R

2019

Wetenschappelijke publicaties

Gal, H., Lysenko, M., Stroganov, S., Vadai, E., Youssef, S. A., Tzadikevitch-Geffen, K., Rotkopf, R., Biron-Shental, T., de Bruin, A., Neeman, M., & Krizhanovsky, V. (2019). Molecular pathways of senescence regulate placental structure and function. EMBO Journal, 38(18), [e100849]. https://doi.org/10.15252/embj.2018100849
Ackermann, T., Hartleben, G., Müller, C., Mastrobuoni, G., Groth, M., Sterken, B. A., Zaini, M. A., Youssef, S. A., Zuidhof, H. R., Krauss, S. R., Kortman, G., de Haan, G., de Bruin, A., Wang, Z. Q., Platzer, M., Kempa, S., & Calkhoven, C. F. (2019). C/EBPβ-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice. Communications Biology, 2(1), [208]. https://doi.org/10.1038/s42003-019-0461-z
Ronda, O. A. H. O., Van De Heijning, B. J. M., De Bruin, A., Jurdzinski, A., Kuipers, F., & Verkade, H. J. (2019). Programming effects of an early-life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet. British Journal of Nutrition, 122, 1321-1328. https://doi.org/10.1017/S0007114519002083
Van Den Berg, M., De Bruin, A., Tervaert, J. W. C., & Sauer, P. J. J. (2019). Rubbergranulaat op kunstgrasvelden: Veilig of niet veilig voor kinderen? Nederlands Tijdschrift voor Geneeskunde, 163(29), [D2339]. https://www.ntvg.nl/artikelen/rubbergranulaat-op-kunstgrasvelden
Martines, A-C. M. F., Gerding, A., Stolle, S., Vieira-Lara, M. A., Wolters, J. C., Jurdzinski, A., Bongiovanni, L., de Bruin, A., van der Vlies, P., van der Vries, G., Bloks, V. W., Derks, T. G. J., Reijngoud, D-J., & Bakker, B. M. (2019). Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Scientific Reports, 9(1), [14539]. https://doi.org/10.1038/s41598-019-50758-0
Kierkels, G. J. J., Scheper, W., Meringa, A. D., Johanna, I., Beringer, D. X., Janssen, A., Schiffler, M., Aarts-Riemens, T., Kramer, L., Straetemans, T., Heijhuurs, S., Leusen, J. H. W., San José, E., Fuchs, K., Griffioen, M., Falkenburg, J. H., Bongiovanni, L., de Bruin, A., Vargas-Diaz, D., ... Kuball, J. (2019). Identification of a tumor-specific allo-HLA-restricted γδTCR. Blood advances, 3(19), 2870-2882. https://doi.org/10.1182/bloodadvances.2019032409
Drescher, H. K., Weiskirchen, R., Fülöp, A., Hopf, C., de San Román, E. G., Huesgen, P. F., de Bruin, A., Bongiovanni, L., Christ, A., Tolba, R., Trautwein, C., & Kroy, D. C. (2019). The Influence of Different Fat Sources on Steatohepatitis and Fibrosis Development in the Western Diet Mouse Model of Non-alcoholic Steatohepatitis (NASH). Frontiers in Physiology, 10, [770]. https://doi.org/10.3389/fphys.2019.00770
Mihajlovic, M., Hariri, S., Westphal, K. C. G., Janssen, M. J., Oost, M. J., Bongiovanni, L., Van Den Heuvel, L. P., De Bruin, A., Hilbrands, L. B., & Masereeuw, R. (2019). Safety evaluation of conditionally immortalized cells for renal replacement therapy. Oncotarget, 10(51), 5332-5348. https://doi.org/10.18632/oncotarget.27152
Yuan, R., Liu, Q., Segeren, H. A., Yuniati, L., Guardavaccaro, D., Lebbink, R. J., Westendorp, B., & de Bruin, A. (2019). Cyclin F-dependent degradation of E2F7 is critical for DNA repair and G2-phase progression. EMBO Journal, 38, [e101430]. https://doi.org/10.15252/embj.2018101430
Johanna, I., Straetemans, T., Heijhuurs, S., Aarts-Riemens, T., Norell, H., Bongiovanni, L., de Bruin, A., Sebestyen, Z., & Kuball, J. (2019). Evaluating in vivo efficacy - toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells. Journal for ImmunoTherapy of Cancer, 7(1), 69. https://doi.org/10.1186/s40425-019-0558-4
Aziz, K., Limzerwala, J. F., Sturmlechner, I., Hurley, E., Zhang, C., Jeganathan, K. B., Nelson, G., Bronk, S., Velasco, R. F., van Deursen, E-J., O'Brien, D. R., Kocher, J-P. A., Youssef, S. A., van Ree, J. H., de Bruin, A., van den Bos, H., Spierings, D. C. J., Foijer, F., van de Sluis, B., ... van Deursen, J. M. (2019). Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice. Gastroenterology, 157(1), 210-226. https://doi.org/10.1053/j.gastro.2019.03.016
van der Schoor, L. W. E., Hulzebos, C. V., van Faassen, M. H., Kema, I., de Bruin, A., Havinga, R., Koster, M., Youssef, S. A., Bongiovanni, L., Jonker, J. W., & Verkade, H. J. (2019). LED-phototherapy does not induce oxidative DNA damage in hyperbilirubinemic Gunn rats. Pediatric Research, 85, 1041-1047. https://doi.org/10.1038/s41390-019-0367-y
Cubero, F. J., Woitok, M. M., Zoubek, M. E., de Bruin, A., Hatting, M., & Trautwein, C. (2019). Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease. Cell death & disease, 10(115), [115]. https://doi.org/10.1038/s41419-019-1391-x
Mohs, A., Kuttkat, N., Otto, T., Youssef, S. A., De Bruin, A., & Trautwein, C. (2019). MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis. Carcinogenesis, 171-181. [41 (2)]. https://doi.org/10.1093/carcin/bgy173
Joshi, B., de Bruin, A., Youssef Hassan, S. A., Kampinga, H. H., & Zuhorn, I. (2019). Exosome-mediated delivery of the chaperone DNAJB6 decreases polyglutamine aggregation in vitro and in vivo. Poster at Keystone conference, Colorado, USA:. Abstract from Keystone conference entitled 'Neurodegenerative Diseases: New Insights and Therapeutic Opportunities'.
Brandsma, E., Kloosterhuis, N. J., Koster, M. H., Dekker, D., Gijbels, M., van der Velden, S., Rios Morales, M., van Faassen, M. J., Loreti, M., de Bruin, A., Fu, J., Kuipers, F., Bakker, B. M., Westerterp, M., de Winther, M. P., Hofker, M. H., van de Sluis, B., & Koonen, D. P. (2019). A Pro-Inflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis. Circulation Research, 124(1), 94-100. https://doi.org/10.1161/CIRCRESAHA.118.313234
Gorissen, B., de Bruin, A., Miranda-Bedate, A., Korthagen, N., Wolschrijn, C., de Vries, T. J., van Weeren, R., & Tryfonidou, M. A. (2019). Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis. Journal of Cellular Physiology, 234, 414-426. https://doi.org/10.1002/jcp.26511

2018

Wetenschappelijke publicaties

Kruitwagen, H. S., Westendorp, B., Viebahn, C. S., Post, K., van Wolferen, M. E., Oosterhoff, L. A., Egan, D. A., Delabar, J-M., Toussaint, M. J., Schotanus, B. A., de Bruin, A., Rothuizen, J., Penning, L. C., & Spee, B. (2018). DYRK1A Is a Regulator of S-Phase Entry in Hepatic Progenitor Cells. Stem Cells and Development, 27(2), 133-146. https://doi.org/10.1089/scd.2017.0139
Segeren, H. A., de Bruin, A., & Westendorp, B. (2018). A single cell approach to explore replication stress tolerance in cancer cells as therapeutic target..
Müller, C. B., Zidek, L. M., Ackermann, T., de Jong, T., Liu, P., Kliche, V., Zaini, M. A., Kortman, G., Harkema, L., Verbeek, D. S., Tuckermann, J. P., von Maltzahn, J., de Bruin, A., Guryev, V., Wang, Z-Q., & Calkhoven, C. F. (2018). Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice. eLife, 7, [e34985]. https://doi.org/10.7554/eLife.34985
Matondo, R. B., Moreno, E., Toussaint, M. J. M., Tooten, P. C. J., van Essen, S. C., van Liere, E. A., Youssef, S. A., Bongiovanni, L., & de Bruin, A. (2018). Atypical E2f functions are critical for pancreas polyploidization. PLoS One, 13(1), [e0190899]. https://doi.org/10.1371/journal.pone.0190899
Yuan, R., Vos, H., van Es, R. M., Chen, J., Burgering, B. M. T., Westendorp, B., & de Bruin, A. (2018). Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest. EMBO Journal, 37(5), [e97877]. https://doi.org/10.15252/embj.201797877
Weijts, B. G. M. W., Westendorp, B., Hien, B. T., Martínez-López, L. M., Zijp, M., Thurlings, I., Thomas, R. E., Schulte-Merker, S., Bakker, W. J., & de Bruin, A. (2018). Atypical E2Fs inhibit tumor angiogenesis. Oncogene, 37, 271-276. https://doi.org/10.1038/onc.2017.336

2017

Wetenschappelijke publicaties

Doktorova, M., Zwarts, I., van Zutphen, T., Van DIjk, T. H., Bloks, V. W., Harkema, L., De Bruin, A., Downes, M., Evans, R. M., Verkade, H. J., & Jonker, J. W. (2017). Intestinal PPARδ protects against diet-induced obesity, insulin resistance and dyslipidemia. Scientific Reports, 7. https://doi.org/10.1038/s41598-017-00889-z
Segura-Bayona, S., Knobel, P. A., González-Burón, H., Youssef, S. A., Peña-Blanco, A., Coyaud, É., López-Rovira, T., Rein, K., Palenzuela, L., Colombelli, J., Forrow, S., Raught, B., Groth, A., de Bruin, A., & Stracker, T. H. (2017). Differential requirements for Tousled-like kinases 1 and 2 in mammalian development. Cell Death and Differentiation, 24(11), 1872-1885. https://doi.org/10.1038/cdd.2017.108
Riedlinger, T., Dommerholt, M. B., Wijshake, T., Kruit, J. K., Huijkman, N., Dekker, D. C., Koster, M., Kloosterhuis, N. J., Koonen, D. P. Y., de Bruin, A., Baker, D., Hofker, M. H., van Deursen, J., Jonker, J. W., Schmitz, M. L., & van de Sluis, B. (2017). NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation. Biochimica et Biophysica Acta, 1864(10), 1785-1798. https://doi.org/10.1016/j.bbamcr.2017.07.005
Windpassinger, C., Piard, J., Bonnard, C., Alfadhel, M., Lim, S., Bisteau, X., Blouin, S., Ali, NA. B., Ng, A. Y. J., Lu, H., Tohari, S., Talib, S. Z. A., van Hul, N., Caldez, M. J., Van Maldergem, L., Yigit, G., Kayserili, H., Youssef, S. A., Coppola, V., ... Kaldis, P. (2017). CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays. American Journal of Human Genetics, 101(3), 391-403. https://doi.org/10.1016/j.ajhg.2017.08.003
de Groot, J. S., van Diest, P. J., van Amersfoort, M., Vlug, E. J., Pan, X., Ter Hoeve, N. D., Rosing, H., Beijnen, J. H., Youssef, S. A., de Bruin, A., Jonkers, J., van der Wall, E., & Derksen, P. W. B. (2017). Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice. Oncotarget, 8(37), 60750-60763. https://doi.org/10.18632/oncotarget.18490
Kent, L. N., Bae, S., Tsai, S. Y., Tang, X., Srivastava, A., Koivisto, C., Martin, C. K., Ridolfi, E., Miller, G. C., Zorko, S. M., Plevris, E., Hadjiyannis, Y., Perez, M., Nolan, E., Kladney, R., Westendorp, B., De Bruin, A., Fernandez, S., Rosol, T. J., ... Leone, G. (2017). Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma. Journal of Clinical Investigation, 127(3), 830-842. https://doi.org/10.1172/JCI87583
Pedone, E., Olteanu, V-A., Marucci, L., Muñoz-Martin, M. I., Youssef, S. A., de Bruin, A., & Cosma, M. P. (2017). Modeling Dynamics and Function of Bone Marrow Cells in Mouse Liver Regeneration. Cell Reports, 18(1), 107-121. https://doi.org/10.1016/j.celrep.2016.12.008
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., Alston, S., Academia, E. C., Kilmarx, S., Valdovinos, A., Wang, B., de Bruin, A., Kennedy, B. K., Melov, S., Zhou, D., ... Campisi, J. (2017). Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discovery, 7(2), 165-176. https://doi.org/10.1158/2159-8290.CD-16-0241
Thurlings, I., Martínez-López, L. M., Westendorp, B., Zijp, M., Kuiper, R., Tooten, P., Kent, L. N., Leone, G., Vos, H. J., Burgering, B., & de Bruin, A. (2017). Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer. Oncogene, 36, 829-839. https://doi.org/10.1038/onc.2016.251
De Cian, M-C., Pauper, E., Bandiera, R., Vidal, V. P. I., Sacco, S., Gregoire, E. P., Chassot, A-A., Panzolini, C., Wilhelm, D., Pailhoux, E., Youssef, S. A., de Bruin, A., de Teerds, K., Schedl, A., Gillot, I., & Chaboissier, M-C. (2017). Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary. Oncogene, 36, 208–218. https://doi.org/10.1038/onc.2016.191

Overige resultaten

Brandsma, E., Kloosterhuis, N. J., Dekker, D. C., Koster, M., Gijbels, M., Van Der Velden, S., de Bruin, A., de Winther, M., Westerterp, M., van de Sluis, B., Koonen, D. P. Y., & Hofker, M. H. (2017). Gut microbiota dysbiosis augments atherosclerosis in LDLR-/- mice. Atherosclerosis, 263, e97. https://doi.org/10.1016/j.atherosclerosis.2017.06.316

2016

Wetenschappelijke publicaties

Kent, L. N., Rakijas, J. B., Pandit, S. K., Westendorp, B., Chen, H. Z., Huntington, J. T., Tang, X., Bae, S., Srivastava, A., Senapati, S., Koivisto, C., Martin, C. K., Cuitino, M. C., Perez, M., Clouse, J. M., Chokshi, V., Shinde, N., Kladney, R., Sun, D., ... Leone, G. (2016). E2f8 mediates tumor suppression in postnatal liver development. Journal of Clinical Investigation, 126(8), 2955-2969. https://doi.org/10.1172/JCI85506
Boekhout, M., Yuan, R., Wondergem, A. P., Segeren, H. A., Van Liere, E. A., Awol, N., Jansen, I., Wolthuis, R. M., De Bruin, A., & Westendorp, B. (2016). Feedback regulation between atypical E2Fs and APC/C Cdh1 coordinates cell cycle progression. EMBO Reports, 17(3), 414-427. https://doi.org/10.15252/embr.201540984
Mohs, A., Kuttkat, N., Reißing, J., Wolfgang Zimmermann, H., Sonntag, R., Proudfoot, A., Youssef, S. A., de Bruin, A., Javier Cubero, F., & Trautwein, C. (Accepted/In press). Functional role of CCL5/RANTES for HCC progression during chronic liver disease. Journal of Hepatology. https://doi.org/10.1016/j.jhep.2016.12.011
Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., Youssef, S. A., Kuiper, R. V., Nagarajah, B., van Oostrom, C. T., Brandt, R. M. C., Barnhoorn, S., Imholz, S., Pennings, J. L. A., de Bruin, A., ... Hoeijmakers, J. H. J. (2016). Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature, 537, 427-431. https://doi.org/10.1038/nature19329
Sudria-Lopez, E., Koppers, M., de Wit, M., van der Meer, C., Westeneng, H-J., Zundel, C. A. C., Youssef, S. A., Harkema, L., de Bruin, A., Veldink, J. H., van den Berg, L. H., & Pasterkamp, R. J. (2016). Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects. Acta Neuropathologica, 132(1), 145-7. https://doi.org/10.1007/s00401-016-1581-x
Catrysse, L., Farhang Ghahremani, M., Vereecke, L., Youssef, S. A., Mc Guire, C., Sze, M., Weber, A., Heikenwalder, M., de Bruin, A., Beyaert, R., & van Loo, G. (2016). A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death. Cell death & disease, 7(6), [e2250]. https://doi.org/10.1038/cddis.2016.154
Matondo, R. B., Toussaint, M. J., Govaert, K. M., van Vuuren, L. D., Nantasanti, S., Nijkamp, M. W., Pandit, S. K., Tooten, P. C., Koster, M. H., Holleman, K., Schot, A., Gu, G., Spee, B., Roskams, T., Rinkes, I. B., Schotanus, B., Kranenburg, O., & de Bruin, A. (2016). Surgical resection and radiofrequency ablation initiate cancer in cytokeratin-19+- liver cells deficient for p53 and Rb. Oncotarget, 7(34), 54662-54675. https://doi.org/10.18632/oncotarget.9952
Nantasanti, S., Toussaint, M. J. M., Youssef , S. A., Tooten, P. C. J., & de Bruin, A. (2016). Rb and p53 Liver Functions Are Essential for Xenobiotic Metabolism and Tumor Suppression. PLoS One, 11(3), [e0150064]. https://doi.org/10.1371/journal.pone.0150064
Terré, B., Piergiovanni, G., Segura-Bayona, S., Gil-Gómez, G., Youssef, S. A., Attolini, C. S-O., Wilsch-Bräuninger, M., Jung, C., Rojas, A. M., Marjanović, M., Knobel, P. A., Palenzuela, L., López-Rovira, T., Forrow, S., Huttner, W. B., Valverde, M. A., de Bruin, A., Costanzo, V., & Stracker, T. H. (2016). GEMC1 is a critical regulator of multiciliated cell differentiation. EMBO Journal, 35(9), 942-960. https://doi.org/10.15252/embj.201592821
Liu, W., Struik, D., Nies, V. J. M., Jurdzinski, A., Harkema, L., de Bruin, A., Verkade, H. J., Downes, M., Evans, R. M., van Zutphen, T., & Jonker, J. W. (2016). Effective treatment of steatosis and steatohepatitis by fibroblast growth factor 1 in mouse models of nonalcoholic fatty liver disease. Proceedings of the National Academy of Sciences of the United States of America, 113(8), 2288-93. https://doi.org/10.1073/pnas.1525093113
Harkema, L., Youssef, S. A., & de Bruin, A. (2016). Pathology of Mouse Models of Accelerated Aging. Veterinary Pathology, 53(2), 366-389. https://doi.org/10.1177/0300985815625169
Nantasanti, S., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2016). Concise Review: Organoids Are a Powerful Tool for the Study of Liver Disease and Personalized Treatment Design in Humans and Animals. Stem cells translational medicine, 5(3), 325–330. https://doi.org/10.5966/sctm.2015-0152
Thurlings, I., & de Bruin, A. (2016). E2F Transcription Factors Control the Roller Coaster Ride of Cell Cycle Gene Expression. Methods in Molecular Biology, 1342, 71-88. https://doi.org/10.1007/978-1-4939-2957-3_4

2015

Wetenschappelijke publicaties

de Bruin, A., Cornelissen, P. W. A., Kirchmaier, B. C., Mokry, M., Iich, E., Nirmala, E., Liang, K-H., Végh, A. M. D., Scholman, K. T., Groot Koerkamp, M. J., Holstege, F. C., Cuppen, E., Schulte-Merker, S., & Bakker, W. J. (2015). Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic Acids Research. https://doi.org/10.1093/nar/gkv1471
Dugal-Tessier, D., Vandenbosch, R., Khacho, M., Weijts, B., Park, D. S., Leone, G., de Bruin, A., & Slack, R. S. (2015). Absence of atypical E2f leads to ventriculomegaly. International Journal of Developmental Neuroscience, 47(Pt A), 14. https://doi.org/10.1016/j.ijdevneu.2015.04.048
Nantasanti, S., Spee, B., Kruitwagen, H. S., Chen, C., Geijsen, N., Oosterhoff, L. A., van Wolferen, M. E., Pelaez, N., Fieten, H., Wubbolts, R. W., Grinwis, G. C., Chan, J., Huch, M., Vries, R. R. G., Clevers, H., de Bruin, A., Rothuizen, J., Penning, L. C., & Schotanus, B. A. (2015). Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids. Stem Cell Reports [E], 5(5), 895-907. https://doi.org/10.1016/j.stemcr.2015.09.002
Donega, V., Nijboer, C. H., van Velthoven, C. T. J., Youssef, S. A., de Bruin, A., van Bel, F., Kavelaars, A., & Heijnen, C. J. (2015). Assessment of long-term safety and efficacy of intranasal mesenchymal stem cell treatment for neonatal brain injury in the mouse. Pediatric Research. https://doi.org/10.1038/pr.2015.145
Deng, L., Ibañez, L. I., Van den Bossche, V., Roose, K., Youssef, S. A., de Bruin, A., Fiers, W., & Saelens, X. (2015). Protection against Influenza A Virus Challenge with M2e-Displaying Filamentous Escherichia coli Phages. PLoS One, 10(5), 1-21. [e0126650]. https://doi.org/10.1371/journal.pone.0126650
van der Heijden, R. A., Sheedfar, F., Morrison, M. C., Hommelberg, P. H., Kor, D., Kloosterhuis, N. J., Gruben, N., Youssef, S. A., de Bruin, A., Hofker, M. H., Kleemann, R., Koonen, D. Y., & Heeringa, P. (2015). High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice. Aging, 7(4), 256-68. https://doi.org/10.18632/aging.100738
https://dspace.library.uu.nl/bitstream/handle/1874/314676/100738.pdf?sequence=1
White, R. R., Milholland, B., de Bruin, A., Curran, S., Laberge, R-M., van Steeg, H., Campisi, J., Maslov, A. Y., & Vijg, J. (2015). Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing. Nature Communications [E], 6, [6790]. https://doi.org/10.1038/ncomms7790
Wu, L., de Bruin, A., Wang, H., Simmons, T., Cleghorn, W., Goldenberg, L. E., Sites, E., Sandy, A., Trimboli, A., Fernandez, S. A., Eng, C., Shapiro, C., & Leone, G. (2015). Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis. Oncogene, 34(1), 119-28. https://doi.org/10.1038/onc.2013.511
Hermsen, R., Toonen, P., Kuijk, E., Youssef, S. A., Kuiper, R., van Heesch, S., de Bruin, A., Cuppen, E., & Simonis, M. (2015). Lack of Major Genome Instability in Tumors of p53 Null Rats. PLoS One, 10(3), [e0122066]. https://doi.org/10.1371/journal.pone.0122066

2014

Wetenschappelijke publicaties

Pruis, M. G. M., Lendvai, A., Bloks, V. W., Zwier, M. V., Baller, J. F. W., de Bruin, A., Groen, A. K., & Plösch, T. (2014). Maternal western diet primes non-alcoholic fatty liver disease in adult mouse offspring. Acta Physiologica, 210(1), 215-27. https://doi.org/10.1111/apha.12197
Sheedfar, F., Sung, M. M., Aparicio-Vergara, M., Kloosterhuis, N. J., Miquilena-Colina, M. E., Vargas-Castrillón, J., Febbraio, M., Jacobs, R. L., de Bruin, A., Vinciguerra, M., García-Monzón, C., Hofker, M. H., Dyck, J. R., & Koonen, D. P. Y. (2014). Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease. Aging, 6(4), 281-95. https://doi.org/10.18632/aging.100652
https://dspace.library.uu.nl/bitstream/handle/1874/314549/cd36.pdf?sequence=1
Reiling, E., Dollé, M. E. T., Youssef, S. A., Lee, M., Nagarajah, B., Roodbergen, M., de With, P., de Bruin, A., Hoeijmakers, J. H., Vijg, J., van Steeg, H., & Hasty, P. (2014). The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency. PLoS One, 9(4), [e93568]. https://doi.org/10.1371/journal.pone.0093568
Van Leeuwen, L. M., Van Der Kuip, M., Youssef, S. A., De Bruin, A., Bitter, W., Marceline Van Furth, A., & Van Der Sar, A. M. (2014). Modeling tuberculous meningitis in zebrafish using Mycobacterium marinum. Disease Models & Mechanisms, 7(9), 1111-1122. https://doi.org/10.1242/dmm.015453
Jongbloed, F., De Bruin, R. W. F., Pennings, J. L. A., Payán-Gómez, C., Van Den Engel, S., Van Oostrom, C. T., De Bruin, A., Hoeijmakers, J. H. J., Van Steeg, H., IJzermans, J. N. M., & Dollé, M. E. T. (2014). Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice. PLoS One, 9(6), [e100853]. https://doi.org/10.1371/journal.pone.0100853
Gruben, N., Vergara, M. A., Kloosterhuis, N. J., Van Der Molen, H., Stoelwinder, S., Youssef, S., De Bruin, A., Delsing, D. J., Kuivenhoven, J. A., Van De Sluis, B., Hofker, M. H., & Koonen, D. P. Y. (2014). Chemokine-like receptor 1 deficiency does not affect the development of insulin resistance and nonalcoholic fatty liver disease in mice. PLoS One, 9(4), [e96345]. https://doi.org/10.1371/journal.pone.0096345
Bartuzi, P., Wijshake, T., Dekker, D. C., Fedoseienko, A., Kloosterhuis, N. J., Youssef, S. A., Li, H., Shiri-Sverdlov, R., Kuivenhoven, J-A., de Bruin, A., Burstein, E., Hofker, M. H., & van de Sluis, B. (2014). A cell-type-specific role for murine Commd1 in liver inflammation. Biochimica et Biophysica Acta, 1842(11), 2257-65. https://doi.org/10.1016/j.bbadis.2014.06.035
Demaria, M., Ohtani, N., Youssef Hassan, S., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., Hoeijmakers, J. H. J., de Bruin, A., Hara, E., & Campisi, J. (2014). An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA. Developmental Cell, 31(6), 722-33. https://doi.org/10.1016/j.devcel.2014.11.012
Bach, F. C., Rutten, K., Hendriks, K., Riemers, F. M., Cornelissen, P., de Bruin, A., Arkesteijn, G. J., Wubbolts, R., Horton, W. A., Penning, L. C., & Tryfonidou, M. A. (2014). The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes. Journal of Cellular Physiology, 229(12), 1999-2014. https://doi.org/10.1002/jcp.24658

2013

Wetenschappelijke publicaties

Pandit, S. K., Westendorp, B., & de Bruin, A. (2013). Physiological significance of polyploidization in mammalian cells. Trends in Cell Biology, 23(11), 556-566. https://doi.org/10.1016/j.tcb.2013.06.002
Magliozzi, R., Low, T. Y., Weijts, B. G. M. W., Cheng, T., Spanjaard, E., Mohammed, S., van Veen, A., Ovaa, H., de Rooij, J., Zwartkruis, G. J. T., Bos, J. L., de Bruin, A., & Heck, A. J. R. (2013). Control of Epithelial Cell Migration and Invasion by the IKKβ- and CK1α-Mediated Degradation of RAPGEF2. Developmental Cell, 27, 574-585. https://doi.org/10.1016/j.devcel.2013.10.023
Choorapoikayil, S., Weijts, B. G. M. W., Kers, R., & de Bruin, A. (2013). Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish. Disease Models & Mechanisms, 6(5), 1159-1166. https://doi.org/10.1242/dmm.012377
Aparacio-Vergara, M., Hommelberg, P. P. H., Schreurs, M., Gruben, N., Stienstra, R., Shiri-Sverdlov, R., Kloosterhuis, N. J., de Bruin, A., van de Sluis, B., Koonen, D. P. Y., & Hofker, M. H. (2013). Tumor Necrosis Factor Receptor 1 Gain-of-Function Mutation Aggravates Nonalcoholic Fatty Liver Disease but Does Not Cause Insulin Resistance in a Murine Model. Hepatology, 57(2), 566-576. https://doi.org/10.1002/hep.26046
Weijts, B. G. M. W., van Impel, A., & de Bruin, A. (2013). Atypical E2fs control lymphangiogenesis through transcriptional regulation of Ccbe1 and Flt4. PLoS One, 8(9), e73693. [e73693]. https://doi.org/10.1371/journal.pone.0073693
Tulinski, P., Fluit, A. C., van Putten, J. P. M., de Bruin, A., Glorieux, S., Wagenaar, J. A., & Duim, B. (2013). An Ex Vivo Porcine Nasal Mucosa Explants Model to Study MRSA Colonization. PLoS One, 8(1), e53783. https://doi.org/10.1371/journal.pone.0053783
Slim, C. L., Lazaro-Dieguez, F., Bijlard, M., Toussaint, M. J. M., de Bruin, A., Du, Q., Musch, A., & IJzendoorn, S. C. (2013). Par1b induces asymmetric inheritance of plasma membrane domains via LGN-dependent mitotic spindle orientation in proliferating hepatocytes. PloS Biology [E], e1001739.
Mans, D. A., Vermaat, J. S. P., Weijts, B. G. M. W., van Rooijen, E., van Reeuwijk, J., Boldt, K., Daenen, L. G. M., van der Groep, P., Rowland, B., Jans, J. J. M., Roepman, R., Voest, E. E., van Diest, P. J., Verhaar, M. C., de Bruin, A., & Giles, R. H. (2013). Regulation of E2F1 by the von Hippel-Lindau tumour suppressor protein predicts survival in renal cell cancer patients. Journal of Pathology, 231(1), 117-129. https://doi.org/10.1002/path.4219
Bakker, W. J., Weijts, B. G. M. W., Westendorp, B., & de Bruin, A. (2013). HIF proteins connect the RB-E2F factors to angiogenesis. Transcription, 4, 62-66. https://doi.org/10.4161/trns.23680

Populariserende publicaties

de Bruin, A. (2013). Subsidie studie foute celdeling. Het Financiële Dagblad; AD/Utrechts Nieuwsblad; AD/Amersfoortse Courant;.

2012

Wetenschappelijke publicaties

Seyednejad, H., Gawlitta, D., Kuiper, R. V., de Bruin, A., van Nostrum, C. F., Vermonden, T., Dhert, W. J. A., & Hennink, W. E. (2012). In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(ε-caprolactone). Biomaterials, 33(17), 4309-18. https://doi.org/10.1016/j.biomaterials.2012.03.002
Weijts, B. G. M. W., Bakker, W. J., Cornelissen, P. W. A., Liang, K. A., Schaftenaar, F. A., Westendorp, B., Wolf, C. A., Paciejewska, M., Scheele, C. L., Kent, L., Leone, G., Schulte-Merker, S., & de Bruin, A. (2012). E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO Journal, 19, 3871-3884. https://doi.org/10.1038/emboj.2012.231
Aranzamendi Esteban, C. R., de Bruin, A., Kuiper, R. V., Boog, C. J. P., van Eden, W., Rutten, V. P. M. G., & Pinelli, E. (2012). Protection against allergic airway inflammation during the chronic and acute phases of Trichinella spiralis infections. Clinical and Experimental Allergy, 43(1), 103-115. https://doi.org/10.1111/cea.12042
Pandit, S. K., Westendorp, B., Nantasanti, S., van Liere, E., Tooten, P. C. J., Cornelissen, P. W. A., Toussaint, M. J. M., Lamers, W. H., & de Bruin, A. (2012). E2F8 is essential for polyploidization in mammalian cells. Nature Cell Biology, 14(11), 1181-1191. https://doi.org/10.1038/ncb2585
Ouseph, M. M., Li, J., Chen, H., Pecot, T., Wenzel, P., Thompson, J., Comstock, G., Chokshi, V., Byrne, M., Forde, B., Chong, J., Huang, K., Machiraju, R., de Bruin, A., & Leone, G. (2012). Atypical E2F Repressors and Activators Coordinate Placental Development. Developmental Cell, 22(4), 849-862. https://doi.org/10.1016/j.devcel.2012.01.013
Choorapoikayil, S., Kuiper, R. V., & de Bruin, A. (2012). Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma. Disease Models & Mechanisms, 5(2), 241-247. https://doi.org/10.1242/dmm.008326
Seyednejad, S. H., Gawlitta, D., Kuiper, R. V., de Bruin, A., van Nostrum, C. F., Vermonden, T., Dhert, W. J. A., & Hennink, W. E. (2012). In vivo biocompatibility and biodegradation of 3D-printed porous scaffolds based on a hydroxyl-functionalized poly(epsilon-caprolactone). Biomaterials, 33(17), 4309-4318. http://www.ncbi.nlm.nih.gov/pubmed/22436798
van Essen, V. J., Uilenreef, J. J., Szatmari, V., Veldhuis - Kroeze, E. J. B., Kuiper, R. V., Rothuizen, J., & de Bruin, A. (2012). Ultrasound-guided serial transabdominal cardiac biopsies in cats. Veterinary Journal, 191(3), 341-346. https://doi.org/10.1016/j.tvjl.2011.02.022
Westendorp, B., Mokry, M., Groot Koerkamp, M. J., Holstege, F. C. P., Cuppen, E. P. J. G., & de Bruin, A. (2012). E2F7 represses a network of oscillating cell cycle genes to control S-phase progression. Nucleic Acids Research, 40(8), 3511-3523. https://doi.org/10.1093/nar/gkr1203
https://dspace.library.uu.nl/bitstream/handle/1874/281319/Westendorp_NuclAcidsRes2012_40_3511_23.pdf?sequence=1

2011

Wetenschappelijke publicaties

Mul, J. D., Nadra, K., Jagalur, N. B., Nijman, I. J., Toonen, P. W., Médard, J., Grès, S., de Bruin, A., Han, G., Brouwers, J. F. H. M., Carman, G. M., Salnier-Blanche, J., Meijer, D., Chrast, R., & Cuppen, E. P. J. G. (2011). A hypomorphic mutation in Lpin1 induces progressively improving neuropathy and lipodsytrophy in the rat. Journal of Biological Chemistry, 286(30), 26781-26793. http://www.ncbi.nlm.nih.gov/pubmed/21715287
van Boxtel, R., Kuiper, R. V., Toonen, P. W., van Heesch, S., de Bruin, A., & Cuppen, E. P. J. G. (2011). Homozygous and Heterozygous p53 Knockout Rats Develop Metastasizing Sarcomas with High Frequency. American Journal of Pathology, 179(4), 1616-1622. http://www.ncbi.nlm.nih.gov/pubmed/21854749

2010

Wetenschappelijke publicaties

da Costa Martins, P. A., Salic, K., Gladka, M., Armand, A. S., Leptidis, S., el Azzouzi, H., Hansen, A., Coenen-de Roo, C. J., Bierhuizen, M. F. A., van der Nagel, R., van Kuik, J., de Weger, R. A., de Bruin, A., Condorelli, G., Arbones, M. L., Eschenhagen, T., & de Windt, L. J. (2010). MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nature Cell Biology, 12, 1220-1227. https://doi.org/10.1038/ncb2126
van Dijk-Ottens, M., Vos, I. H. C., Cornelissen, P. W. A., de Bruin, A., & Everts, M. E. (2010). Thyroid hormone-induced cardiac mechano growth factor expression depends on beating activity. Endocrinology, 151(2), 830-838.
de Keizer, P. L. J., Packer, L. M., Szypowska, A. A., Riedl-Polderman, P. E., van den Broek, N. J. F., de Bruin, A., Dansen, T. B., Marais, R., Brenkman, A. B., & Burgering, B. M. T. (2010). Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Research, 70(21), 8526-8536.

2009

Wetenschappelijke publicaties

Matondo, R., Punt, C., Homberg, J. R., Toussaint, M. J. M., Kisjes, R., Korporaal, S. J. A., Akkerman, J. W. N., Cuppen, E., & de Bruin, A. (2009). Deletion of the serotonin transporter in rats disturbs serotonin homeostasis without impairing liver regeneration. American Journal of Physiology-Gastrointestinal and Liver Physiology, 296, G963-G968.
Aqeilan, R. I., Hagan, J. P., de Bruin, A., Rawahneh, M., Salah, Z., Gaudio, E., Siddiqui, H., Volinia, S., Adler, H., Lian, J. B., Stein, G., & Croce, C. M. (2009). Targeted ablation of the Wwox tumor suppressor leads to impaired steroidogenesis. Endocrinology, 150, 1530-1535.
https://dspace.library.uu.nl/bitstream/handle/1874/37507/Aqeilan%25202%2520et%2520al%25202008.pdf?sequence=1
Kester, M. H., Toussaint, M. J. M., Punt, A. C., Matondo, R., Aarnio, A. M., Darras, V. M., Everts, M. E., de Bruin, A., & Visser, T. J. (2009). Large induction of type III deiodinase (D3) expression after partial hepatectomy in the regenerating mouse and rat liver. Endocrinology, 150, 540-545.
https://dspace.library.uu.nl/bitstream/handle/1874/37505/Kester%2520et%2520al%25202008.pdf?sequence=1

2008

Wetenschappelijke publicaties

Li, J., Ran, C., Li, E., Gordon, F., Comstock, G., Siddiqui, H., Cleghorn, W., Chen, H., Kornacker, K., Pandit, S. K., Khanizadeh, M., Weinstein, M., Leone, G., & de Bruin, A. (2008). Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Developmental Cell, 14, 62-75.
https://dspace.library.uu.nl/bitstream/handle/1874/32199/Li%2520et%2520al%25202008.pdf?sequence=1
van Boxtel, R., Toonen, P., van Roekel, H., Verheul, M., Smits, B. M., Korving, J., de Bruin, A., & Cuppen, E. (2008). Lack of DNA mismatch repair protein MSH6 in the rat results in hereditary non-polyposis colorectal cancer-like tumorigenesis. Carcinogenesis, 29, 1290-1297.
https://dspace.library.uu.nl/bitstream/handle/1874/31980/Boxtel%2520et%2520al%25202008.pdf?sequence=1
Mosaliganti, K., Pan, T., Ridgway, R., Sharp, R., Cooper, L., Gulacy, A., Sharma, A., Irfanoglu, O., Machiraju, R., Kurc, T., de Bruin, A., Wenzel, P., Leone, G., Saltz, J., & Huang, K. (2008). An imaging workflow for characterizing phenotypical change in large histological mouse model datasets. Journal of Biomedical Informatics, 41, 863-873.
https://dspace.library.uu.nl/bitstream/handle/1874/32243/Mosaliganti%2520et%2520al%25202008.pdf?sequence=1
Aqeilan, R. I., Hassan, M. Q., de Bruin, A., Hagan, J. P., Volinia, S., Palumbo, T., Hussain, S., Lee, S., Gaur, T., Stein, G., Lian, J. B., & Croce, C. M. (2008). The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism. Journal of Biological Chemistry, 283, 21629-21639.
https://dspace.library.uu.nl/bitstream/handle/1874/32201/Aqeilan%2520et%2520al%25202008.pdf?sequence=1
Trimboli, A. J., Fukino, F., de Bruin, A., Wei, G., Shen, L., Tanner, S. M., Creasap, N., Rosol, T. J., Robinson, M. L., Eng, C., Ostrowski, M. C., & Leone, G. (2008). Direct evidence for Epithelial-Mesenchymal transitions in breast cancer. Cancer Research, 68, 937-945.
https://dspace.library.uu.nl/bitstream/handle/1874/32200/Trimboli%2520et%2520al%25202008.pdf?sequence=1
Tsai, S. Y., Opavsky, R., Sharma, N., Wu, L., Naidu, S., Nolan, E., Feria-Arias, E., Timmers, C., Opavska, J., de Bruin, A., Chong, J., Trikha, P., Fernandez, S., Stromberg, P., Rosol, T. J., & Leone, G. (2008). Mouse development with a single E2F activator. Nature, 454, 1137-1141.
https://dspace.library.uu.nl/bitstream/handle/1874/32202/Tsai%2520et%2520al%25202008.pdf?sequence=1

2007

Wetenschappelijke publicaties

Wenzel, P. L., Wu, L. L., de Bruin, A., Chong, J., Chen, W., Dureska, G., Sites, E., Pan, T., Sharma, A., Huang, K., Ridgway, R., Mosaliganti, K., Sharp, R., Machiraju, R., Saltz, J., Yamamoto, H., Cross, J. C., Robinson, M. L., & Leone, G. (2007). Rb is critical in a mammalian tissue stem cell population. Genes and Development, 21, 85-97.
https://dspace.library.uu.nl/bitstream/handle/1874/26109/Wenzel%2520et%2520al%25202007.pdf?sequence=1
Mosaliganti, K., Janoos, F., Sharp, R., Ridgway, R., Machiraju, R., Huang, K., Wenzel, P. L., de Bruin, A., Leone, G., & Saltz, J. (2007). Detection and visualization of surface-pockets to enable phenotyping studies. IEEE Transactions on Medical Imaging, 26(9), 1283-1290.
de Bruin, A., Caldelari, R., Williamson, L., Suter, M. M., Hunziker, T., Wyder, M., & Muller, E. J. (2007). Plakoglobin-dependent disruption of the desmosomal plaque in pemphigus vulgaris. Experimental Dermatology, 6, 468-475.
https://dspace.library.uu.nl/bitstream/handle/1874/26108/bruin%2520et%2520al%25202007.pdf?sequence=1

2006

Wetenschappelijke publicaties

Williamson, L., Raess, N. A., Caldelari, R., Zakher, A., de Bruin, A., Posthaus, H., Bolli, R., Hunziker, T., Suter, M. M., & Muller, E. J. (2006). Pemphigus vulgaris identifies plakoglobin as key suppressor of c-Myc in the skin. EMBO Journal, 25(14), 3298-3309.
https://dspace.library.uu.nl/bitstream/handle/1874/20236/Bruin%2520et%2520al%2520%282006%29%2520pdf.pdf?sequence=1

2005

Wetenschappelijke publicaties

de Bruin, A., Wack, R., & Weisbrode, S. E. (2005). Persistent metanephric ducts in a geriatric white tiger. Journal of Veterinary Diagnostic Investigation, 17(1), 91-3.
Maiti, B., Li, J., de Bruin, A., Gordon, F., Timmers, C., Opavsky, R., Patil, K., Tuttle, J., Cleghorn, W., & Leone, G. (2005). Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. Journal of Biological Chemistry, 280(18), 18211-20. https://doi.org/10.1074/jbc.M501410200
Jiang, Y., de Bruin, A., Caldas, H., Fangusaro, J., Hayes, J., Conway, E. M., Robinson, M. L., & Altura, R. A. (2005). Essential role for survivin in early brain development. Journal of Neuroscience, 25(30), 6962-70. https://doi.org/10.1523/JNEUROSCI.1446-05.2005

2003

Wetenschappelijke publicaties

Wu, L., de Bruin, A., Saavedra, H. I., Starovic, M., Trimboli, A., Yang, Y., Opavska, J., Wilson, P., Thompson, J. C., Ostrowski, M. C., Rosol, T. J., Woollett, L. A., Weinstein, M., Cross, J. C., Robinson, M. L., & Leone, G. (2003). Extra-embryonic function of Rb is essential for embryonic development and viability. Nature, 421(6926), 942-7. https://doi.org/10.1038/nature01417
de Bruin, A., Wu, L., Saavedra, H. I., Wilson, P., Yang, Y., Rosol, T. J., Weinstein, M., Robinson, M. L., & Leone, G. (2003). Rb function in extraembryonic lineages suppresses apoptosis in the CNS of Rb-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 100(11), 6546-51. https://doi.org/10.1073/pnas.1031853100
de Bruin, A., Maiti, B., Jakoi, L., Timmers, C., Buerki, R., & Leone, G. (2003). Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. Journal of Biological Chemistry, 278(43), 42041-9. https://doi.org/10.1074/jbc.M308105200

2002

Wetenschappelijke publicaties

Dahm, A. M., de Bruin, A., Linat, A., von Tscharner, C., Wyder, M., & Suter, M. M. (2002). Cultivation and characterisation of primary and subcultured equine keratinocytes. Equine Veterinary Journal, 34(2), 114-20.
Saavedra, H. I., Wu, L., de Bruin, A., Timmers, C., Rosol, T. J., Weinstein, M., Robinson, M. L., & Leone, G. (2002). Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth & Differentiation, 13(5), 215-25.

2001

Wetenschappelijke publicaties

Köhler, H. B., Huchzermeyer, B., Martin, M., De Bruin, A., Meier, B., & Nolte, I. (2001). TNF-alpha dependent NF-kappa B activation in cultured canine keratinocytes is partly mediated by reactive oxygen species. Veterinary Dermatology, 12(3), 129-37.
Caldelari, R., de Bruin, A., Baumann, D., Suter, M. M., Bierkamp, C., Balmer, V., & Müller, E. (2001). A central role for the armadillo protein plakoglobin in the autoimmune disease pemphigus vulgaris. Journal of Cell Biology, 153(4), 823-34.

2000

Wetenschappelijke publicaties

Caldelari, R., Suter, M. M., Baumann, D., De Bruin, A., & Müller, E. (2000). Long-term culture of murine epidermal keratinocytes. Journal of Investigative Dermatology, 114(5), 1064-5. https://doi.org/10.1046/j.1523-1747.2000.00960-4.x
Müller, E., Caldelari, R., de Bruin, A., & Suter, M. M. (2000). Störungen der Zelladhäsion bei autoimmunen bullösen Hautkrankheiten. Schweizer Archiv fur Tierheilkunde, 142(5), 241-6.

1999

Wetenschappelijke publicaties

Köhler, H. B., Knop, J., Martin, M., de Bruin, A., Huchzermeyer, B., Lehmann, H., Kietzmann, M., Meier, B., & Nolte, I. (1999). Involvement of reactive oxygen species in TNF-alpha mediated activation of the transcription factor NF-kappaB in canine dermal fibroblasts. Veterinary Immunology and Immunopathology, 71(2), 125-42.
De Bruin, A., Müller, E., Wurm, S., Caldelari, R., Wyder, M., Wheelock, M. J., & Suter, M. M. (1999). Loss of invasiveness in squamous cell carcinoma cells overexpressing desmosomal cadherins. Cell Adhesion and Communication, 7(1), 13-28.
de Bruin, A., Müller, E., Wyder, M., Anhalt, G. J., Lemmens, P., & Suter, M. M. (1999). Periplakin and envoplakin are target antigens in canine and human paraneoplastic pemphigus. Journal of the American Academy of Dermatology, 40(5 Pt 1), 682-5.

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