Publicaties
2022
Wetenschappelijke publicaties
Sepers, J. J., Ramalho, J. J., Kroll, J. R., Schmidt, R., & Boxem, M. (2022). ERM-1 Phosphorylation and NRFL-1 Redundantly Control Lumen Formation in the C. elegans Intestine. Frontiers in Cell and Developmental Biology, 10, 1-17. [769862]. https://doi.org/10.3389/fcell.2022.769862
Sepers, J. J., Verstappen, N. H. M., Vo, A. A., Ragle, J. M., Ruijtenberg, S., Ward, J. D., & Boxem, M. (2022). The mIAA7 degron improves auxin-mediated degradation in Caenorhabditis elegans. G3: Genes, Genomes, Genetics, 12(10), 1-15. [jkac222]. https://doi.org/10.1093/g3journal/jkac222
Castiglioni, V. G., Ramalho, J. J., Kroll, J. R., Stucchi, R., van Beuzekom, H., Schmidt, R., Altelaar, M., & Boxem, M. (2022). Identification and characterization of Crumbs polarity complex proteins in Caenorhabditis elegans. Journal of Biological Chemistry, 298(4), 1-16. [101786]. https://doi.org/10.1016/j.jbc.2022.101786
2021
Wetenschappelijke publicaties
Kroll, J. R., Remmelzwaal, S., & Boxem, M. (2021). CeLINC, a fluorescence-based protein-protein interaction assay in Caenorhabditis elegans. Genetics, 219(4), 1-14. [iyab163]. https://doi.org/10.1093/genetics/iyab163
Riga, A., Cravo, J., Schmidt, R., Pires, H. R., Castiglioni, V. G., van den Heuvel, S., & Boxem, M. (2021). Caenorhabditis elegans LET-413 Scribble is essential in the epidermis for growth, viability, and directional outgrowth of epithelial seam cells. PLoS Genetics, 17(10), 1-30. [e1009856]. https://doi.org/10.1371/journal.pgen.1009856
Remmelzwaal, S., Geisler, F., Stucchi, R., van der Horst, S., Pasolli, M., Kroll, J. R., Jarosinska, O. D., Akhmanova, A., Richardson, C. A., Altelaar, M., Leube, R. E., Ramalho, J. J., & Boxem, M. (2021). BBLN-1 is essential for intermediate filament organization and apical membrane morphology. Current Biology, 31(11), 2334-2346.e9. https://doi.org/10.1016/j.cub.2021.03.069
2020
Wetenschappelijke publicaties
Castiglioni, V. G., Pires, H. R., Bertolini, R. R., Riga, A., Kerver, J., & Boxem, M. (2020). Epidermal par-6 and pkc-3 are essential for larval development of c. Elegans and organize non-centrosomal microtubules. eLife, 9, 1-37. [e62067]. https://doi.org/10.7554/ELIFE.62067
Pelgrom, A. J. E., Meisrimler, C-N., Elberse, J., Koorman, T., Boxem, M., & Van den Ackerveken, G. (2020). Host interactors of effector proteins of the lettuce downy mildew Bremia lactucae obtained by yeast two-hybrid screening. PLoS One, 15(5), [e0226540]. https://doi.org/10.1371/journal.pone.0226540
Ramalho, J. J., Sepers, J. J., Nicolle, O., Schmidt, R., Cravo, J., Michaux, G., & Boxem, M. (2020). C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during Caenorhabditiselegans development. Development (Cambridge, England), 147(14), [dev188011 ]. https://doi.org/10.1242/dev.188011
Yao, Z., Aboualizadeh, F., Kroll, J., Akula, I., Snider, J., Lyakisheva, A., Tang, P., Kotlyar, M., Jurisica, I., Boxem, M., & Stagljar, I. (2020). Split Intein-Mediated Protein Ligation for detecting protein-protein interactions and their inhibition. Nature Communications, 11(1), [2440]. https://doi.org/10.1038/s41467-020-16299-1
Riga, A., Castiglioni, V. G., & Boxem, M. (2020). New insights into apical-basal polarization in epithelia. Current Opinion in Cell Biology, 62, 1-8. https://doi.org/10.1016/j.ceb.2019.07.017
2019
Wetenschappelijke publicaties
Remmelzwaal, S., & Boxem, M. (2019). Protein interactome mapping in Caenorhabditis elegans. Current Opinion in Systems Biology, 13, 1-9. https://doi.org/10.1016/j.coisb.2018.08.006
Malinow, R. A., Ying, P., Koorman, T., Boxem, M., Jin, Y., & Kim, K. W. (2019). Functional Dissection of C. elegans bZip-Protein CEBP-1 Reveals Novel Structural Motifs Required for Axon Regeneration and Nuclear Import. Frontiers in Cellular Neuroscience, 13, [348]. https://doi.org/10.3389/fncel.2019.00348
Boxem, M., & van den Heuvel, S. (2019). Cell Polarity: Getting the PARty Started. Current Biology, 29(13), R637-R639. https://doi.org/10.1016/j.cub.2019.05.032
2018
Wetenschappelijke publicaties
García-Rodríguez, F. J., Martínez-Fernández, C., Brena, D., Kukhtar, D., Serrat, X., Nadal, E., Boxem, M., Honnen, S., Miranda-Vizuete, A., Villanueva, A., & Cerón, J. (2018). Genetic and cellular sensitivity of to the chemotherapeutic agent cisplatin. Disease Models & Mechanisms, 11(6). https://doi.org/10.1242/dmm.033506
Ribeiro Pires, H., & Boxem, M. (2018). Mapping the Polarity Interactome. Journal of Molecular Biology, 430(19), 3521-3544. https://doi.org/10.1016/j.jmb.2017.12.017
2017
Wetenschappelijke publicaties
Amendola, P. G., Zaghet, N., Ramalho, J. J., Vilstrup Johansen, J., Boxem, M., & Salcini, A. E. (2017). JMJD-5/KDM8 regulates H3K36me2 and is required for late steps of homologous recombination and genome integrity. PLoS Genetics, 13(2), 1-24. [e1006632]. https://doi.org/10.1371/journal.pgen.1006632
2016
Wetenschappelijke publicaties
Portegijs, V., Fielmich, L-E., Galli, M., Schmidt, R., Munoz Peralta, J., van Mourik, T., Akhmanova, A., Heck, A. J. R., Boxem, M., & van den Heuvel, S. (2016). Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans. PLoS Genetics, 12(10), 1-32. [e1006291]. https://doi.org/10.1371/journal.pgen.1006291
Waaijers, S., Muñoz, J., Berends, C., Ramalho, J. J., Goerdayal, S. S., Low, T. Y., Zoumaro-Djayoon, A. D., Hoffmann, M., Koorman, T., Tas, R. P., Harterink, M., Seelk, S., Kerver - Stumpfova, J., Hoogenraad, C. C., Bossinger, O., Tursun, B., van den Heuvel, S., Heck, A. J. R., & Boxem, M. (2016). A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. BMC Biology, 14, [66]. https://doi.org/10.1186/s12915-016-0286-x
https://dspace.library.uu.nl/bitstream/handle/1874/341483/protein.pdf?sequence=1
https://dspace.library.uu.nl/bitstream/handle/1874/341483/protein.pdf?sequence=1
Koorman, T., Klompstra, D., van der Voet, M., Lemmens, I., Ramalho, J. J., Nieuwenhuize, S., van den Heuvel, S., Tavernier, J., Nance, J., & Boxem, M. (2016). A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Nature Cell Biology, 18(3), 337–346 . https://doi.org/10.1038/ncb3300
2015
Wetenschappelijke publicaties
Chen, L., Chuang, M., Koorman, T., Boxem, M., Jin, Y., & Chisholm, A. D. (2015). Axon injury triggers EFA-6 mediated destabilization of axonal microtubules via TACC and doublecortin like kinase. eLife, 4. https://doi.org/10.7554/eLife.08695
Waaijers, S., De Amil Da Costa Jacob Ramalho, J., Koorman, T., Kruse, E., & Boxem, M. (2015). The C. elegans Crumbs family contains a CRB3 homolog and is not essential for viability. Biology Open, 4(3), 276-284. https://doi.org/10.1242/bio.201410744
The, I., Ruijtenberg, S., Bouchet, B. P., Cristobal Gonzalez de Durana, A., Prinsen, M. B. W., van Mourik, T., Koreth, J., Xu, H., Heck, A. J. R., Akhmanova, A., Cuppen, E., Boxem, M., Munoz Murillo, A., & van den Heuvel, S. (2015). Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells. Nature Communications [E], 6, 5906. https://doi.org/10.1038/ncomms6906
2014
Wetenschappelijke publicaties
Waaijers, S., & Boxem, M. (2014). Engineering the Caenorhabditis elegans genome with CRISPR/Cas9. Methods, 68(3), 381-388. https://doi.org/10.1016/j.ymeth.2014.03.024
de Albuquerque, B. F. M., Luteijn, M. J., Cordeiro Rodrigues, R. J., van Bergeijk, P., Waaijers, S., Kaaij, L. J. T., Klein, H., Boxem, M., & Ketting, R. F. (2014). PID-1 is a novel factor that operates during 21U-RNA biogenesis in Caenorhabditis elegans. Genes and Development, 28(7), 683-688. https://doi.org/10.1101/gad.238220.114
Sapir, A., Tsur, A., Koorman, T., Ching, K., Mishra, P., Bardenheier, A., Podolsky, L., Bening-Abu-Shach, U., Boxem, M., Chou, T-F., Broday, L., & Sternberg, P. W. (2014). Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging. Proceedings of the National Academy of Sciences of the United States of America, 111(37), E3880–E3889. https://doi.org/10.1073/pnas.1414748111
Overige resultaten
Koorman, T., van der Voet, M., Klompstra, D., De Amil Da Costa Jacob Ramalho, J., Nieuwenhuize, S., van den Heuvel, S., Nance, J., & Boxem, M. (2014). Unraveling the C. elegans interactome underlying cell polarity. Poster session presented at Cell polarity and membrane trafficking (Pultusk, Poland), Pultusk, Poland.
Koorman, T., van der Voet, M., Klompstra, D., De Amil Da Costa Jacob Ramalho, J., Nieuwenhuize, S., van den Heuvel, S., Nance, J., & Boxem, M. (2014). Unraveling the C. elegans interactome underlying cell polarity. Poster session presented at Berlin C. elegans meeting, Berlin, Germany.
2013
Wetenschappelijke publicaties
Waaijers, S., Portegijs, V. C., Kerver, J., Lemmens, B. B. L. G., Tijsterman, M., van den Heuvel, S., & Boxem, M. (2013). CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans. Genetics, 195, 1173-1176. https://doi.org/10.1534/genetics.113.155754
Berends, C. W. H., Muñoz, J., Portegijs, V. C., Schmidt, R., Grigoriev, I. S., Boxem, M., Akhmanova, A. S., Heck, A. J. R., & van den Heuvel, S. (2013). F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Molecular Biology of the Cell, 24(14), 2201-2215. https://doi.org/10.1091/mbc.E13-02-0076
Wang, Z., Hou, Y., Guo, X., van der Voet, M., Boxem, M., Dixon, J. E., Chisholm, A. D., & Jin, Y. (2013). The EBAX-type Cullin-RING E3 ligase and Hsp90 guard the protein quality of the SAX-3/Robo receptor in developing neurons. Neuron, 79(5), 903-16. https://doi.org/10.1016/j.neuron.2013.06.035
Waaijers, S., Koorman, T., Kerver, J., & Boxem, M. (2013). Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. Journal of Proteome Research, 12(7), 3181-3192. https://doi.org/10.1021/pr400047p
Overige resultaten
Waaijers, S., Koorman, T., Kerver, J., & Boxem, M. (2013). Protein interaction domain mapping using the yeast two-hybrid system. Poster session presented at The 5th EMBO Meeting, RAI, Amsterdam, The Netherlands.
Koorman, T., van der Voet, M., Ramalho, J. C., van den Heuvel, S., & Boxem, M. (2013). Unraveling the interactome underlying cell polarity. Poster session presented at 19th International C. elegans meeting, Los Angeles, UCLA.
Waaijers, S., Portegijs, V. C., Kerver-Stumpfova, J., Lemmens, B. B. L. G., van den Heuvel, S., & Boxem, M. (2013). CRISPR/Cas9-targeted mutagenesis in C. elegans. Poster session presented at The 5th EMBO Meeting, RAI, Amsterdam, The Netherlands.
Waaijers, S., Zoumaro-Djayoon, A. D., Goerdayal, S. S., Munoz, J., Heck, A. J. R., & Boxem, M. (2013). Tissue-specific purification of protein complexes in C. elegans. Poster session presented at 19th International C. elegans meeting, Los Angeles, UCLA.
Waaijers, S., Portegijs, V. C., Kerver-Stumpfova, J., Lemmens, B. B. L. G., van den Heuvel, S., & Boxem, M. (2013). CRISPR/Cas9-targeted mutagenesis in C. elegans. Poster session presented at Dutch meeting on Molecular and Cellular Biophysics 2013, Veldhoven, The Netherlands, NH Hoteles.
2012
Wetenschappelijke publicaties
Boxem, M., Maliga, Z., Klitgord, N., Li, N., Lemmens, I., Mana, M., De Lichtervelde, L., Mul, J. D., Van De Peut, D., Devos, M., Simonis, N., Yildirim, M. A., Cokol, M., Kao, H. L., De Smet, A. S., Wang, H., Schlaitz, A. L., Hao, T., Milstein, S., ... Vidal, M. (2012). Erratum: A protein domain-based interactome network for C. elegans early embryogenesis (Cell (2008) 134 (534-545)). Cell, 151(7), 1633. https://doi.org/10.1016/j.cell.2012.11.042
2011
Wetenschappelijke publicaties
Galli, M., Munoz, J., Portegijs, V. C., Boxem, M., Grill, S. W., Heck, A. J. R., & van den Heuvel, S. J. L. (2011). aPKC phosphorylates NuMa-related LIN-5 to position the mitotic spindle during asymmetric division. Nature Cell Biology, 13(9), 1132-1138. https://doi.org/10.1038/ncb2315
Mukhtar, M. S., Carvunis, A. R., Dreze, M., Epple, P., Steinbrenner, J., Moore, J., Tasan, M., Galli, M., Hao, T., Nishimura, M. T., Pevzner, P. A., Donovan, S. E., Ghamsari, L., Santhanam, B., Romero, V., Poulin, M. M., Gebreab, F., Gutierrez, B. J., Tam, S., ... Dangl, J. L. (2011). Independently Evolved Virulence Effectors Converge onto Hubs in a Plant Immune System network. Science, 333, 596-601.
Korzelius, J. P., The, S. I., Ruijtenberg, S. A., Prinsen, M. B., Portegijs, V. C., Middelkoop, T. C., Groot Koerkamp, M. J. A., Holstege, F. C. P., Boxem, M., & van den Heuvel, S. (2011). Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells. PLoS Genetics, 7(11), e1002362. https://doi.org/10.1371/journal.pgen.1002362
Overige resultaten
Boxem, M. (2011). Tissue-specific composition of polarity complexes in C. elegans epithelia. Poster session presented at Structure and Dynamics of Protein Networks Symposium, Heidelberg, Germany.
Boxem, M. (2011). Tissue-specific identification of polarity protein complexes. Poster session presented at 18th International C. elegans meeting, Los Angeles, CA, USA.
2009
Wetenschappelijke publicaties
Simonis, N., Rual, J-F., Carvunis, A. R., Tasan, M., Lemmens, I., Hirozane-Kishikawa, T., Hao, T., Sahalie, J. M., Venkatesan, K., Gebreab, F., Cevik, S., Klitgord, N., Fan, C., Braun, P., Li, N., Ayivi-Guedehoussou, N., Dann, E., Bertin, N., Szeto, D., ... Vidal, M. (2009). Empirically controlled mapping of the Caenorhabditis elegans protein interactome network. Nature Methods, 6(1), 47-54.
Dreze, M., Charloteaux, B., Milstein, S., Vidalain, P. O., Yildirim, M. A., Zhong, Q., Svrzikapa, N., Romero, V., Laloux, G., Brasseur, R., Vandenhaute, J., Boxem, M., Cusick, M. E., Hill, D. E., & Vidal, M. (2009). 'Edgetic' pertubation of a C. elegans BCL2 ortholog. Nature Methods, 6(11), 843-849.
Sillé, F. C., Boxem, M., Sprengers, D., Veerapen, N., Besra, G. S., & Boes, M. L. (2009). Distinct requirements for CD1d intracellular transport for development of V(alpha) 14 iNKT cells. Journal of Immunology, 183(3), 1780-1788.
van der Voet, M., Berends, C. W. H., Perrealt, A., Nguyen-Ngoc, T., Gönczy, P., Vidal, M., Boxem, M., & van den Heuvel, S. (2009). NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Gg. Nature Cell Biology, 11(3), 269-277.
2008
Wetenschappelijke publicaties
Komatsu, H., Chao, M. Y., Larkins-Ford, J., Corkins, M. E., Somers, G. A., Tucey, T., Dionne, H. M., White, J. Q., Wani, K., Boxem, M., & Hart, A. C. (2008). OSM-11 facilitates LIN-12 notch signaling during Caenorhabditis elegans vulval development. PLoS Biology, 6(8), 1730-1745. [e196]. https://doi.org/10.1371/journal.pbio.0060196
Boxem, M., Maliga, Z., Klitgord, N., Li, N., Lemmens, I., Mana, M., de Lichtervelde, L., Mul, J. D., van de Peut, D., Devos, M., Simonis, N., Yildirim, M. A., Cokol, M., Kao, H. L., Smet, A. S., Wang, H., Schlaitz, A. L., Hao, T., Milstein, S., ... Vidal, M. (2008). A protein domain-based interactome network for C. elegans early embryogenesis. Cell, 134(3), 534-545.
Overige resultaten
Berends, C. W. H., Munoz Peralta, J., van der Voet, M., Boxem, M., Krijgsveld, J., Heck, A. J., & van den Heuvel, S. (2008). Regulation of asymmetric cell division through the cortical LIN-5 complex in C. elegans. Poster session presented at NWO-CW study groups meeting, Veldhoven.
2007
Overige resultaten
van der Voet, M., Berends, C. W. H., Boxem, M., & van den Heuvel, S. (2007). NuMA-related LIN-5, ASPM-1, Calmodulin and dynein promote meotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Poster session presented at Annual Meeting of the American Society for Cell Biology, San Francisco, CA, USA.
2006
Wetenschappelijke publicaties
Boxem, M. (2006). Cyclin-dependent kinases in C. elegans. Cell Division, 1, [6]. https://doi.org/10.1186/1747-1028-1-6
Overige resultaten
Korzelius, J. P., Ceron, J., Boxem, M., Portegijs, V. C., Christiaan, S. C. C., & van den Heuvel, S. J. L. (2006). Regulation of cell proliferation versus differentiation in C. elegans. Poster session presented at C. elegans Development Meeting, Madison, Wisconsin, United States.
van der Voet, M., Wildwater, M., Boxem, M., Peters, J., Berends, C. W. H., Galli, M., The, S. I., Thomas, A. A. M., & van den Heuvel, S. J. L. (2006). The function of LIN-5 in chromosome segregation and asymmetric division. Poster session presented at European Worm Meeting, Heraklion, Crete, Greece.
Korzelius, J. P., Ceron, J., Boxem, M., Portegijs, V. C., Christiaan, S. C. C., & van den Heuvel, S. J. L. (2006). Regulation of cell proliferation versus differentiation in C. elegans. Poster session presented at European Worm Meeting, Heraklion, Crete, Greece.
2005
Overige resultaten
Boxem, M., Klitgord, N., Hyman, H., van den Heuvel, S. J. L., & Vidal, M. (2005). Toward a domain interaction map of C. elegans early embryogenesis. Poster session presented at 15th International C. elegans Conference, Los Angeles, California, United States.
Koreth, J., Boxem, M., Korzelius, J. P., Xu, H., Na, L., Chandra, A., Orkin, S., & van den Heuvel, S. J. L. (2005). He121: a suppressor of cyclin D1 in C. elegans. Poster session presented at 15th International C. elegans Conference, Los Angeles, California, United States.
2004
Wetenschappelijke publicaties
Tewari, M., Hu, P. J., Ahn, J. S., Ayivi-Guedehoussou, N., Vidalain, P. O., Li, S., Milstein, S., Armstrong, C. M., Boxem, M., Butler, M. D., Busiguina, S., Rual, J. F., Ibarrola, N., Chaklos, S. T., Bertin, N., Vaglio, P., Edgley, M. L., King, K. V., Albert, P. S., ... Vidal, M. (2004). Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-β signaling network. Molecular Cell, 13(4), 469-482. https://doi.org/10.1016/S1097-2765(04)00033-4
Li, S., Armstrong, C. M., Bertin, N., Ge, H., Milstein, S., Boxem, M., Vidalain, P-O., Han, J-D. J., Chesneau, A., Hao, T., Goldberg, D. S., Li, N., Martinez, M., Rual, J-F., Lamesch, P., Xu, L., Tewari, M., Wong, S. L., Zhang, L. V., ... Vidal, M. (2004). A Map of the Interactome Network of the Metazoan C. elegans. Science, 303(5657), 540-544. https://doi.org/10.1126/science.1091403
2002
Wetenschappelijke publicaties
Boxem, M., & Van den Heuvel, S. (2002). C. elegans class B synthetic multivulva genes act in G1 regulation. Current Biology, 12(11), 906-911. https://doi.org/10.1016/S0960-9822(02)00844-8
2001
Wetenschappelijke publicaties
Boxem, M., & Van den Heuvel, S. (2001). lin-35 Rb and cki-1 Cip/Kip cooperative in developmental regulation of G1 progression in C. elegans. Development, 128(21), 4349-4359.
1999
Wetenschappelijke publicaties
Boxem, M., Srinivasan, D. G., & van den Heuvel, S. (1999). The Caenorhabditis elegans gene ncc-1 encodes a cdc2-related kinase required for M phase in meiotic and mitotic cell divisions, but not for S phase. Development (Cambridge, England), 126(10), 2227-39. http://dev.biologists.org/content/develop/126/10/2227.full.pdf
1997
Wetenschappelijke publicaties
Willemsen, P. T., Vulto, I., Boxem, M., & De Graaff, J. (1997). Characterization of a periplasmic protein involved in iron utilization of Actinobacillus actinomycetemcomitans. Journal of Bacteriology, 179(15), 4949-4952. https://doi.org/10.1128/jb.179.15.4949-4952.1997