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Prof. dr. J.A. (Antoinette) Killian

Emeritus 
Bètawetenschappen
Scheikunde
Scheikunde Algemeen
Scheikunde Algemeen
Hugo R. Kruytgebouw
Padualaan 8
Kamer Z802
3584 CH Utrecht

Prof. dr. J.A. (Antoinette) Killian

Emeritus
Scheikunde Algemeen
030 253 3442
j.a.killian@uu.nl
Profiel CV Publicaties Onderzoek Onderwijs Nevenwerkzaamheden Contact
Profiel CV Publicaties Onderzoek Onderwijs Nevenwerkzaamheden Contact
Onderzoeksthema's

Publicaties

2022

Wetenschappelijke publicaties

Kopf, A. H., Lijding, O., Elenbaas, B. O. W., Koorengevel, M. C., Dobruchowska, J. M., Walree, C. A. V., & Killian, J. A. (2022). Synthesis and Evaluation of a Library of Alternating Amphipathic Copolymers to Solubilize and Study Membrane Proteins. Biomacromolecules. https://doi.org/10.1021/acs.biomac.1c01166

2021

Wetenschappelijke publicaties

Olerinyova, A., Sonn-Segev, A., Gault, J., Eichmann, C., Schimpf, J., Kopf, A. H., Rudden, L. S. P., Ashkinadze, D., Bomba, R., Frey, L., Greenwald, J., Degiacomi, M. T., Steinhilper, R., Killian, J. A., Friedrich, T., Riek, R., Struwe, W. B., & Kukura, P. (2021). Mass Photometry of Membrane Proteins. Chem, 7(1), 224-236. https://doi.org/10.1016/j.chempr.2020.11.011

2020

Wetenschappelijke publicaties

Luteijn, R. D., Praest, P., Thiele, F., Sadasivam, S. M., Singethan, K., Drijfhout, J. W., Bach, C., de Boer, S. M., Lebbink, R. J., Tao, S., Helfer, M., Bach, N. C., Protzer, U., Costa, A. I., Killian, J. A., Drexler, I., & Wiertz, E. J. H. J. (2020). A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope. Cells, 9(9), [1989]. https://doi.org/10.3390/cells9091989
Cunningham, R. D., Kopf, A. H., Elenbaas, B. O. W., Staal, B. B. P., Pfukwa, R., Killian, J. A., & Klumperman, B. (2020). Iterative RAFT-Mediated Copolymerization of Styrene and Maleic Anhydride toward Sequence- And Length-Controlled Copolymers and Their Applications for Solubilizing Lipid Membranes. Biomacromolecules, 21(8), 3287-3300. https://doi.org/10.1021/acs.biomac.0c00736
Kopf, A. H., Dörr, J. M., Koorengevel, M. C., Antoniciello, F., Jahn, H., & Killian, J. A. (2020). Factors influencing the solubilization of membrane proteins from Escherichia coli membranes by styrene–maleic acid copolymers. Biochimica et Biophysica Acta - Biomembranes, 1862(2). https://doi.org/10.1016/j.bbamem.2019.183125

2019

Wetenschappelijke publicaties

Saravanan, M. S., Ryazanov, S., Leonov, A., Nicolai, J., Praest, P., Giese, A., Winter, R., Khemtemourian, L., Griesinger, C., & Killian, J. A. (2019). The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers. Scientific Reports, 9(1), [19023]. https://doi.org/10.1038/s41598-019-54919-z
Domínguez Pardo, J. J., van Walree, C. A., Egmond, M. R., Koorengevel, M. C., & Killian, J. A. (2019). Nanodiscs bounded by styrene-maleic acid allow trans-cis isomerization of enclosed photoswitches of azobenzene labeled lipids. Chemistry and Physics of Lipids, 220, 1-5. https://doi.org/10.1016/j.chemphyslip.2019.02.002
Kopf, A. H., Koorengevel, M. C., van Walree, C. A., Dafforn, T. R., & Killian, J. A. (2019). A simple and convenient method for the hydrolysis of styrene-maleic anhydride copolymers to styrene-maleic acid copolymers. Chemistry and Physics of Lipids, 218, 85-90. https://doi.org/10.1016/j.chemphyslip.2018.11.011

2018

Wetenschappelijke publicaties

Liu, Y., Moura, E. C. C. M., Dörr, J. M., Scheidelaar, S., Heger, M., Egmond, M. R., Killian, J. A., Mohammadi, T., & Breukink, E. (2018). Correction: Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers. PLoS One, 13(12), e0210135. https://doi.org/10.1371/journal.pone.0210135
Hoffmann, A. R. F., Saravanan, M. S., Lequin, O., Killian, J. A., & Khemtemourian, L. (2018). A single mutation on the human amyloid polypeptide modulates fibril growth and affects the mechanism of amyloid-induced membrane damage. Biochimica et Biophysica Acta - Biomembranes, 1860(9), 1783-1792. https://doi.org/10.1016/j.bbamem.2018.02.018
Domínguez Pardo, J. J., Koorengevel, M. C., Uwugiaren, N., Weijers, J., Kopf, A. H., Jahn, H., van Walree, C. A., van Steenbergen, M. J., & Killian, J. A. (2018). Membrane Solubilization by Styrene-Maleic Acid Copolymers: Delineating the Role of Polymer Length. Biophysical Journal, 115(1), 129-138. https://doi.org/10.1016/j.bpj.2018.05.032
Liu, Y., Moura, E. C. C. M., Dörr, J. M., Scheidelaar, S., Heger, M., Egmond, M. R., Killian, J. A., Mohammadi, T., & Breukink, E. (2018). Bacillus subtilis MraY in detergent-free system of nanodiscs wrapped by styrene-maleic acid copolymers. PLoS One, 13(11), [e0206692]. https://doi.org/10.1371/journal.pone.0206692

2017

Wetenschappelijke publicaties

Dörr, J. M., van Coevorden-Hameete, M. H., Hoogenraad, C. C., & Killian, J. A. (2017). Solubilization of human cells by the styrene-maleic acid copolymer: Insights from fluorescence microscopy. Biochimica et Biophysica Acta, 1859(11), 2155-2160. https://doi.org/10.1016/j.bbamem.2017.08.010
Khemtemourian, L. P., Guillemain, G., Foufelle, F., & Killian, J. A. (2017). Residue specific effects of human islet polypeptide amyloid on self-assembly and on cell toxicity. Biochimie, 142, 22-30. https://doi.org/10.1016/j.biochi.2017.07.015
Swainsbury, D. J. K., Scheidelaar, S., Foster, N., Van Grondelle, R., Killian, J. A., & Jones, M. R. (2017). The effectiveness of styrene-maleic acid (SMA) copolymers for solubilisation of integral membrane proteins from SMA-accessible and SMA-resistant membranes. Biochimica et Biophysica Acta - Biomembranes, 1859(10), 2133-2143. https://doi.org/10.1016/j.bbamem.2017.07.011
Dominguez Pardo, J. J., Dörr, J. M., Renne, M. F., Ould-Braham , T., Koorengevel, M. C., van Steenbergen, M., & Killian, J. A. (2017). Thermotropic properties of phosphatidylcholine nanodiscs bounded by styrene-maleic acid copolymers. Chemistry and Physics of Lipids, 208, 58-64. https://doi.org/10.1016/j.chemphyslip.2017.08.010
Bersch, B., Dörr, J. M., Hessel, A., Killian, J. A., & Schanda, P. (2017). Proton-Detected Solid-State NMR Spectroscopy of a Zinc Diffusion Facilitator Protein in Native Nanodiscs. Angewandte Chemie-International Edition, 56(9), 2508–2512. https://doi.org/10.1002/anie.201610441
Dominguez Pardo, J. J., Dörr, J. M., Iyer, A., Cox, R. C., Scheidelaar, S., Koorengevel, M. C., Subramaniam, V., & Killian, J. A. (2017). Solubilization of lipids and lipid phases by the styrene-maleic acid copolymer. European Biophysics Journal, 46(1), 91-101. https://doi.org/10.1007/s00249-016-1181-7

2016

Wetenschappelijke publicaties

Scheidelaar, S., Koorengevel, M. C., van Walree, C. A., Dominguez Pardo, J., Dörr, J. M., & Killian, J. A. (2016). Effect of Polymer Composition and pH on Membrane Solubilization by Styrene-Maleic Acid Copolymers. Biophysical Journal, 111(9), 1974-1986. https://doi.org/10.1016/j.bpj.2016.09.025
Dörr, J. M., Scheidelaar, S., Koorengevel, M. C., Dominguez Pardo, J., Schäfer, M., van Walree, C. A., & Killian, J. A. (2016). The styrene-maleic acid copolymer: a versatile tool in membrane research. European Biophysics Journal, 45(1), 3-21. https://doi.org/10.1007/s00249-015-1093-y

Overige resultaten

Gruber, J. M., Scheidelaar, S., Van Roon, H., Dekker, J. P., Killian, J. A., & Van Grondelle, R. (2016). Photophysics in single light-harvesting complexes II: from micelle to native nanodisks. https://doi.org/10.1117/12.2211588

2015

Wetenschappelijke publicaties

Scheidelaar, S., Swainsbury, D., Koorengevel, M., Meeldijk, H., Breukink, E., van Grondelle, R., Jones, M., & Killian, J. A. (2015). Detergent-Free Extraction of the Reaction Center from Rhodobacter sphaeroides into Native Nanodiscs. Nanodisc Size Matters! Biophysical Journal, 108(2). https://doi.org/10.1016/j.bpj.2014.11.3048
Killian, J. A. (2015). Studying lipid/protein interactions: From selfassembled model membranes to native nanodiscs. European Biophysics Journal, 44(1), 44. https://doi.org/10.1007/s00249-015-1045-6
Furse, S., Egmond, M. R., & Killian, J. A. (2015). Isolation of lipids from biological samples. Molecular Membrane Biology, 32(3), 55-64. https://doi.org/10.3109/09687688.2015.1050468
Scheidelaar, S., Koorengevel, M. C., Pardo, J. D., Meeldijk, J. D., Breukink, E., & Killian, J. A. (2015). Molecular Model for the solubilization of membranes into nanodisks by styrene maleic acid copolymers. Biophysical Journal, 108(2), 279-290. https://doi.org/10.1016/j.bpj.2014.11.3464
Furse, S., Wienk, H., Boelens, R., de Kroon, A. I. P. M., & Killian, J. A. (2015). E. coli MG1655 modulates its phospholipid composition through the cell cycle. FEBS Letters, 589(19), 2726-2730. https://doi.org/10.1016/j.febslet.2015.07.043
Cybulski, L., Ballering, J., Moussatova, A., Inda, M. E., Vazquez, D. B., Wassenaar, T. A., de Mendoza, D., Tieleman, D. P., & Killian, J. A. (2015). Activation of the bacterial thermosensor DesK involves a serine zipper dimerization motif that is modulated by bilayer thickness. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.1422446112

2014

Wetenschappelijke publicaties

Scheidelaar, S., Koorengevel, M., Swainsbury, D., Meeldijk, H., Breukink, E., Jones, M., van Grondelle, R., & Killian, A. (2014). Detergent-Free Extraction of Membrane Proteins into Native Nanodiscs. Application to the Reaction center of Rhodobacter Sphaeroides. Biophysical Journal, 106(2), 90a. https://doi.org/10.1016/j.bpj.2013.11.572
Swainsbury, D. J. K., Scheidelaar, S., Van Grondelle, R., Killian, J. A., & Jones, M. R. (2014). Bacterial reaction centers purified with styrene maleic acid copolymer retain native membrane functional properties and display enhanced stability. Angewandte Chemie - International Edition, 53(44), 11803-11807. https://doi.org/10.1002/anie.201406412
Dörr, J. M., Koorengevel, M. C., Schäfer, M., Prokofyev, A. V., Scheidelaar, S., van der Cruijsen, E. A. W., Dafforn, T. R., Baldus, M., & Killian, J. A. (2014). Detergent-free isolation, characterization, and functional reconstitution of a tetrameric K+ channel: The power of native nanodiscs. Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18607–18612. https://doi.org/10.1073/pnas.1416205112

2013

Wetenschappelijke publicaties

Scheidelaar, S., Koorengevel, M. C., Meeldijk, H., Breukink, E., & Killian, A. (2013). Towards Detergent Free Solubilization of Membrane Proteins into Nanodiscs: A Biophysical Study on the Interaction between Styrene Maleic Acid (SMA) Copolymers and Synthetic Phospholipid Vesicles. Biophysical Journal, 104(2). https://doi.org/10.1016/j.bpj.2012.11.3313
Furse, S. R., & Killian, J. A. (2013). Lipase Activity in Lipidomics – A Hidden Problem? Molecular Membrane Biology, 30(7), 347-349. https://doi.org/10.3109/09687688.2013.835125

2012

Wetenschappelijke publicaties

Doux, J. P. F., Hall, B. A., & Killian, J. A. (2012). How lipid headgroups sense the membrane environment: An application of 14N NMR. Biophysical Journal, 103(6), 1245-1253. https://doi.org/10.1016/j.bpj.2012.08.031

2011

Wetenschappelijke publicaties

Lönnfors, M., Doux, J. P. F., Killian, J. A., Nyholm, T. K. M., & Slotte, J. P. (2011). Sterols have higher affinity for sphingomyelin than for phosphatidylcholine bilayers even at equal Acyl-chain order. Biophysical Journal, 100(11), 2633-2641. https://doi.org/10.1016/j.bpj.2011.03.066
Khemtemourian, L. P., Doménech, E., Doux, J. P. F., Koorengevel, M. C., & Killian, J. A. (2011). Low pH Acts as inhibitor of membrane damage induced by human islet amyloid polypeptide. Journal of the American Chemical Society, 133(39), 15598-15604. https://doi.org/10.1021/ja205007j
Nyholm, T. K. M., van Duyl, B. Y., Rijkers, D. T. S., Liskamp, R. M. J., & Killian, J. A. (2011). Probing the lipid-protein interface using model transmembrane peptides with a covalently linked acyl chain. Biophysical Journal, 101, 1959-1967.
Bonnet, S., Limburg, B., Meeldijk, J. D., Gebbink, R. J., & Killian, J. A. (2011). Ruthenium-decorated lipid vesicles: light-induced release of [Ru(terpy)(bpy)(OH(2))](2+) and thermal back coordination. Journal of the American Chemical Society, 133(2), 252-261.
Bonnet, S. A., Limburg, B., Meeldijk, J. D., Klein Gebbink, R. J. M., & Killian, J. A. (2011). Ruthenium-decorated lipid vesicles: light-induced release of [Ru(terpy)(bpy)(oh2)]2+ and thermal back coordination. Journal of the American Chemical Society, 133(2), 252-261. https://doi.org/10.1021/ja105025m

2010

Wetenschappelijke publicaties

Holt, A., & Killian, J. A. (2010). Orientation and dynamics of transmembrane peptides: the power of simple models. European Biophysics Journal, 39(4), 609-621. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952093470&partnerID=40&md5=d6182f4a6f894579beab1296b8ca0a24
Khemtemourian, L. P., Engel, M. F. M., Liskamp, R. M. J., Höppener, J. W. M., & Killian, J. A. (2010). The N-terminal fragment of human islet amyloid polypeptide is non-fibrillogenic in the presence of membranes and does not cause leakage of bilayers of physiologically relevant lipid composition. Biochimica et Biophysica Acta-Biomembranes, 1798(9), 1805-1811.
Markvoort, A. J., Pfleger, N., Staffhorst, R. W. H. M., Hilbers, P. A. J., van Santen, R. A., Killian, J. A., & de Kruijff, B. (2010). Self-reproduction of fatty acid vesicles: a combined experimental and simulation study. Biophysical Journal, 99(5), 1520-1528. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956546786&partnerID=40&md5=e0ddf266f1820cd1394bd95f59382b65
Holt, A., Rougier, L., Réat, V., Jolibois, F., Saurel, O., Czaplicki, J., Killian, J. A., & Milon, A. (2010). Order parameters of a transmembrane helix in a fluid Bilayer: case study of a WALP peptide. Biophysical Journal, 98(9), 1864-1872.
van Gestel, R. A., Rijken, P. J., Surinova, S., O'Flaherty, M., Heck, A. J. R., Killian, J. A., de Kroon, A. I. P. M., & Slijper, M. (2010). The influence of the acyl chain composition of cardiolipin on the stability of mitochondrial complexes; An unexpected effect of cardiolipin in α-ketoglutarate dehydrogenase and prohibitin complexes. Journal of Proteomics, 73(4), 806-814. http://www.scopus.com/inward/record.url?eid=2-s2.0-74849123638&partnerID=40&md5=8d25891dcf14b62fd2c86c96c3373efa
Khemtemourian, L. P., Engel, M. F. M., Kruijtzer, J. A. W., Hoppener, J. W. M., Liskamp, R. M. J., & Killian, J. A. (2010). The role of the disulfide bond in the interaction of islet amyloid polypeptide with membranes. European Biophysics Journal, 39, 1359-1364.
Ulmschneider, M. B., Doux, J. P. F., Killian, J. A., Smith, J. C., & Ulmschneider, J. P. (2010). Mechanism and kinetics of peptide partitioning into membranes from all-atom simulations of thermostable peptides. Journal of the American Chemical Society, 132(10), 3452-3460. https://doi.org/10.1021/ja909347x
Ramadurai, S., Holt, A., Schäfer, L. V., Krasnikov, V. V., Rijkers, D. T. S., Marrink, S. J., Killian, J. A., & Poolman, B. (2010). Influence of hydrophobic mismatch and amino acid composition on the lateral diffusion of transmembrane peptides. Biophysical Journal, 99, 1447-1454.

2009

Wetenschappelijke publicaties

Ulmschneider, J. P., Doux, J. P. F., Killian, J. A., Smith, J. C., & Ulmschneider, M. B. (2009). Peptide partitioning and folding into lipid bilayers. Journal of Chemical Theory and Computation, 5(9), 2202-2205. https://doi.org/10.1021/ct900256k
Holt, A., Koehorst, R. B. M., Rutters-Meijneke, T., Gelb, M. H., Rijkers, D. T. S., Hemminga, M. A., & Killian, J. A. (2009). Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy. Biophysical Journal, 97, 2258-2266.
Ramadurai, S., Holt, A., Krasnikov, V., van den Bogaart, G., Killian, J. A., & Poolman, B. (2009). Lateral diffusion of membrane proteins. Journal of the American Chemical Society, 131(35), 12650-12656.
Khemtémourian, L. P., Lahoz Casarramona, G., Suylen, D. P., Hackeng, T. M., Meeldijk, J. D., de Kruijff, B., Hoppener, J. W. M., & Killian, J. A. (2009). Impaired processing of human pro-islet amyloid polypeptide is not a causative factor for fibril formation or membrane damage in vitro. Biochemistry, 48(46), 10918-10925. http://www.doi.org/10.1021/bi901076d
Scarpelli, F., Drescher, M., Rutters-Meijneke, T., Holt, A., Rijkers, D. T. S., Killian, J. A., & Huber, M. (2009). Aggregation of transmembrane peptides studied by spin-label EPR. Journal of Physical Chemistry. B, 113, 12257-12264.
Code, C., Domanov, Y. A., Killian, J. A., & Kinnunen, P. K. J. (2009). Activation of phospholipase A2 by temporin B: Formation of antimicrobial peptide-enzyme amyloid-type cofibrils. Biochimica et Biophysica Acta-Biomembranes, 1788(5), 1064-1072.

Overige resultaten

Rutters-Meineke, T., Rijkers, D. T. S., Liskamp, R. M. J., & Killian, J. A. (2009). Studying membrane proteins using covalent assemblies of well-defined model peptides. 454a. Abstract from Unknown event, Asilomar, USA.

2008

Wetenschappelijke publicaties

Khemtémourian, L. P., Killian, J. A., Höppener, J. W. M., & Engel, M. F. M. (2008). Recent insights in islet amyloid polypeptide-induced membrane disruption and its role in β-cell death in type II diabetes mellitus. Experimental Diabetes Research, 2008, 421287/1-421287/9.
https://dspace.library.uu.nl/bitstream/handle/1874/32177/7Khemt_233_mourian-Recent%2520insights.pdf?sequence=1
Ozdirekcan, S., Nyholm, T. K. M., Raja, M., Rijkers, D. T. S., Liskamp, R. M. J., & Killian, J. A. (2008). Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides. Biophysical Journal, 94, 1315-1325.
https://dspace.library.uu.nl/bitstream/handle/1874/32607/12_214_zdirekcan-Influence%2520of%2520trifluoroethanol.pdf?sequence=1
Engel, M. F. M., Khemtemourian, L. P., Kleijer, C. C., Meeldijk, J. D., Jacobs, J., Verkleij, A. J., de Kruijff, B., Killian, J. A., & Hoppener, J. W. M. (2008). Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane. Proceedings of the National Academy of Sciences of the United States of America, 105, 6033-6038.
https://dspace.library.uu.nl/bitstream/handle/1874/32223/4Engel-Membrane%2520damage.pdf?sequence=1
Holt, A., de Almeida, R. F. M., Nyholm, T. K. M., Loura, L. M. S., Daily, A. E., Staffhorst, R. W. H. M., Rijkers, D. T. S., Koeppe II, R. E., Prieto, M., & Killian, J. A. (2008). Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins? Biochemistry, 47, 2638-2649.
https://dspace.library.uu.nl/bitstream/handle/1874/32604/6Holt-Is%2520there%2520a%2520preferential.pdf?sequence=1
Killian, J. A. (2008). Looking at membrane lipids from the inside of the cell. Nature Chemical Biology, 4(3), 164-165.
https://dspace.library.uu.nl/bitstream/handle/1874/33210/8Killian-Looking%2520at%2520membrane.pdf?sequence=1
Barrera, F. N., Renard, M. L., Poveda, J. A., de Kruijff, B., Killian, J. A., & González-Ros, J. M. (2008). Protein self-assembly and lipid binding in the folding of the potassium channel KcsA. Biochemistry, 47, 2123-2133.
https://dspace.library.uu.nl/bitstream/handle/1874/33048/2Barrera-Protein%2520self-assembly.pdf?sequence=1

Overige resultaten

Meijneke, T., Rijkers, D. T. S., Liskamp, R. M. J., & Killian, J. A. (2008). The synthesis of covalent assemblies of model peptides to study membrane proteins. 31. Abstract from The 30th European Peptide Symposium.

2007

Wetenschappelijke publicaties

Raja, M. M., Spelbrink, R. E. J., de Kruijff, B., & Killian, J. A. (2007). Phosphatidic acid plays a special role in stabilizing and folding of the tetrameric potassium channel KcsA. FEBS Letters, 581, 5715-5722.
https://dspace.library.uu.nl/bitstream/handle/1874/26632/Raja-Phosphatidic%2520acid.pdf?sequence=1
Özdirekcan, S., Etchebest, C., Killian, J. A., & Fuchs, P. F. J. (2007). On the orientation of a designed transmembrane peptide: toward the right tilt angle? Journal of the American Chemical Society, 129(49), 15174-15180.
Nyholm, T. K. M., Özdirekcan, S., & Killian, J. A. (2007). How protein transmembrane segments sense the lipid environment. Biochemistry, 46, 1457-1465.
https://dspace.library.uu.nl/bitstream/handle/1874/26604/Nyholm-How%2520protein%2520transmembrane.pdf?sequence=1
Akitake, B., Spelbrink, R. E. J., Anishkin, A., Killian, J. A., de Kruijff, B., & Sukharev, S. (2007). 2,2,2-Trifluoroethanol changes the transition kinetics and subunit interactions in the small bacterial mechanosensitive channel MscS. Biophysical Journal, 92, 2771-2784.
https://dspace.library.uu.nl/bitstream/handle/1874/26598/Akitake-2%2C2%2C2-Trifluoroethanol.pdf?sequence=1

2006

Wetenschappelijke publicaties

de Kruijff, B., Killian, J. A., Ganchev, D. N., Rinia, H. A., & Sparr, E. M. (2006). Striated domains: self-organizing ordered assemblies of transmembrane α-helical peptides and lipids in bilayers. Biological Chemistry, 387, 235-241.
https://dspace.library.uu.nl/bitstream/handle/1874/20000/DeKruijff-Striated%2520domains.pdf?sequence=1
Killian, J. A., & Nyholm, T. K. M. (2006). Peptides in lipid bilayers: the power of simple models. Current Opinion in Structural Biology, 16, 473-479.
https://dspace.library.uu.nl/bitstream/handle/1874/20054/11%2520Killian-Peptides%2520in%2520lipid.pdf?sequence=1
Engel, M. F. M., Yigittop, H., Elgersma, R. C., Rijkers, D. T. S., Liskamp, R. M. J., de Kruijff, B., Hoppener, J. W. M., & Killian, J. A. (2006). Islet amyloid polypeptide inserts into phospholipid monolayers as monomer. Journal of Molecular Biology, 356, 783-789.
https://dspace.library.uu.nl/bitstream/handle/1874/19275/Engel-Islet%2520amyloid.pdf?sequence=1
Siegel, D. P., Cherezov, V., Greathouse, D. V., Koeppe II, R. E., Killian, J. A., & Caffrey, M. (2006). Transmembrane peptides stabilize inverted cubic phases in a biphasic length-dependent manner: implications for protein-induced membrane fusion. Biophysical Journal, 90, 200-211.
https://dspace.library.uu.nl/bitstream/handle/1874/19983/12%2520Siegel-Transmembrane%2520peptides.pdf?sequence=1

2005

Wetenschappelijke publicaties

Sparr, E., Ash, W. L., Nazarov, P. V., Rijkers, D. T. S., Hemminga, M. A., Tieleman, D. P., & Killian, J. A. (2005). Self-association of transmembrane α-helices in model membranes: Importance of helix orientation and role of hydrophobic mismatch. Journal of Biological Chemistry, 280(47), 39324-39331. https://doi.org/10.1074/jbc.M502810200
Spelbrink, R. E. J., Kolkman, A., Slijper, M., Killian, J. A., & de Kruijff, B. (2005). Detection and identification of stable oligomeric protein complexes in Escherichia coli inner membranes. Journal of Biological Chemistry, 280, 28742-28748.
https://dspace.library.uu.nl/bitstream/handle/1874/7773/Spelbrink-Detection%2520and%2520identification.pdf?sequence=2
Sparr, E. M., Ganchev, D. N., Snel, M. M. E., Ridder, A. N. J. A., Kroon-Batenburg, L. M. J., Chupin, V. V., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2005). Molecular organization in striated domains induced by transmembrane alpha-helical peptides in dipalmitoyl phosphatidylcholine bilayers. Biochemistry, 44, 2-10. https://doi.org/10.1021/bi048047a
van Duyl, B. Y., Meeldijk, J. D., Verkleij, A. J., Rijkers, D. T. S., Chupin, V. V., de Kruijff, B., & Killian, J. A. (2005). A synergistic effect between cholesterol and tryptophan-flanked transmembrane helices modulates membrane curvature. Biochemistry, 44(11), 4526-4532.
https://dspace.library.uu.nl/bitstream/handle/1874/7921/VanDuyl-A%2520synergistic%2520effect.pdf?sequence=2
Özdirekcan, S., Rijkers, D. T. S., Liskamp, R. M. J., & Killian, J. A. (2005). Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study. Biochemistry, 44, 1004-1012.
https://dspace.library.uu.nl/bitstream/handle/1874/7795/Ozdirekcan-Influence%2520of%2520flanking.pdf?sequence=2
Rijkers, D. T. S., Kruijtzer, J. A. W., Killian, J. A., & Liskamp, R. M. J. (2005). A convenient solid phase synthesis of S-palmitoyl transmembrane peptides. Tetrahedron Letters, 46, 3341-3345.
https://dspace.library.uu.nl/bitstream/handle/1874/7796/Rijkers-A%2520convenient%2520solid.pdf?sequence=2
Sparr, E. M., Ash, W. L., Nazarov, P. V., Rijkers, D. T. S., Hemminga, M. A., & Killian, J. A. (2005). Self-association of transmembrane alfa-helices in model membranes. Journal of Biological Chemistry, 280, 39324-39331.
https://dspace.library.uu.nl/bitstream/handle/1874/7794/Sparr-Self-association%2520supp.pdf?sequence=2

2004

Wetenschappelijke publicaties

Strandberg, E. J., Özdirekcan, S., Rijkers, D. T. S., van der Wel, P. C. A., Koeppe II, R. E., Liskamp, R. M. J., & Killian, J. A. (2004). Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H Solid State NMR. Biophysical Journal, 86, 3709-3721.
https://dspace.library.uu.nl/bitstream/handle/1874/14623/Strandberg-Tilt%2520angles.pdf?sequence=1
Kol, M. A., de Kroon, A. I. P. M., Killian, J. A., & de Kruijff, B. (2004). Transbilayer movement of phospholipids in biogenic membranes. Biochemistry, 43, 2673-2681.
https://dspace.library.uu.nl/bitstream/handle/1874/14618/Kol-Transbilayer%2520movement.pdf?sequence=1
van den Brink - van der Laan, E., Chupin, V. V., Killian, J. A., & de Kruijff, B. (2004). Small alcohols destabilize the KcsA tetramer via their effect on the membrane lateral pressure. Biochemistry, 43, 5937-5942.
https://dspace.library.uu.nl/bitstream/handle/1874/14610/VandenBrink-Small%2520alcohols.pdf?sequence=1
Sparr, E. M., Engel, M. F. M., Sakharov, D., Sprong, M. G. H., Jacobs, J., de Kruijff, B., Höppener, J. W. M., & Killian, J. A. (2004). Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers. FEBS Letters, 577, 117-120.
https://dspace.library.uu.nl/bitstream/handle/1874/14621/Sparr-Islet%2520amyloid.pdf?sequence=1
Ridder, A. N. J. A., Spelbrink, R. E. J., Demmers, J. A. A., Rijkers, D. T. S., Liskamp, R. M. J., Brunner, J., Heck, A. J. R., de Kruijff, B., & Killian, J. A. (2004). Photo-crosslinking analysis of preferential interactions between a transmembrane peptide and matching lipids. Biochemistry, 43, 4482-4489.
https://dspace.library.uu.nl/bitstream/handle/1874/14449/Ridder-Photo-crosslinking%2520analysis.pdf?sequence=1
Ganchev, D. N., Rijkers, D. T. S., Snel, M. M. E., Killian, J. A., & de Kruijff, B. (2004). Strength of integration of transmembrane α-helical peptides in lipid bilayers as determined by Atomic Force Spectroscopy. Biochemistry, 43(47), 14987-14993. https://doi.org/10.1021/bi048372y
van den Brink - van der Laan, E., Chupin, V. V., Killian, J. A., & de Kruijff, B. (2004). Stability of KcsA tetramer depends on membrane lateral pressure. Biochemistry, 43, 4240-4250.
https://dspace.library.uu.nl/bitstream/handle/1874/14627/VandenBrink-Stability.pdf?sequence=1
van den Brink - van der Laan, E., Killian, J. A., & de Kruijff, B. (2004). Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile. Biochimica et Biophysica Acta-Biomembranes, 1666, 275-288.
https://dspace.library.uu.nl/bitstream/handle/1874/14611/VandenBrink-Nonbilayer%2520lipids.pdf?sequence=1
Andronesi, O. C., Pfeifer, J. R., Al-Momani, L., Özdirekcan, S., Rijkers, D. T. S., Angerstein, B., Luca, S., Koert, U., Killian, J. A., & Baldus, M. (2004). Probing membrane protein orientation and structure using fast magic-angle-spinning solid-state NMR. Journal of Biomolecular NMR, 30, 253-265.

Overige resultaten

van Duyl, B. Y., Rijkers, D. T. S., Chupin, V. V., de Kruijff, B., & Killian, J. A. (2004). Isotropic phase formation in bilayer lipids: synergistic effect of cholesterol and transmembrane peptides. B23. Abstract from Unknown event, Asilomar, USA.

2003

Wetenschappelijke publicaties

Killian, J. A. (2003). Synthetic peptides as models for intrinsic membrane proteins (minireview). FEBS Letters, 555, 134-138.
Demmers, J. A. A., van Dalen, A., de Kruijff, B., Heck, A. J. R., & Killian, J. A. (2003). Interaction of the K+ channel KcsA with membrane phospholipids as studied by ESI mass spectrometry. FEBS Letters, 541, 28-32. https://www.sciencedirect.com/science/article/pii/S0014579303002825
de Planque, M. R. R., & Killian, J. A. (2003). Protein-lipid interactions studied with designed transmembrane peptides: role of hydrophobic matching and interfacial anchoring (review). Molecular Membrane Biology, 20(4), 271-284. https://doi.org/10.1080/09687680310001605352
van Duyl, B. Y., Ganchev, D. N., Chupin, V. V., de Kruijff, B., & Killian, J. A. (2003). Sphingomyelin is much more effective than saturated phosphatidylcholine in excluding unsaturated phosphatidylcholine from domains formed with cholesterol. FEBS Letters, 547(1-3), 101-106. https://doi.org/10.1016/S0014-5793(03)00678-1
de Planque, M. R. R., Bonev, B. B., Demmers, J. A. A., Greathouse, D. V., Koeppe II, R. E., Separovic, F., Watts, A., & Killian, J. A. (2003). Interfacial anchor properties of tryptophan residues in transmembrane peptides can dominate over hydrophobic matching effects in peptide-lipid interactions. Biochemistry, 42, 5341-5348.
https://dspace.library.uu.nl/bitstream/handle/1874/14370/DePlanque-Interfacial%2520anchor.pdf?sequence=1
van den Brink - van der Laan, E., Boots, J. W. P., Spelbrink, R. E. J., Kool, G. M., Breukink, E. J., Killian, J. A., & de Kruijff, B. (2003). Membrane interaction of the glycolsyltransferase MurG: a special role for cardiolipin. Journal of Bacteriology, 185, 3773-3779.
https://dspace.library.uu.nl/bitstream/handle/1874/14366/VandenBrink-Membrane%2520interaction.pdf?sequence=1
Kol, M. A., van Laak, A. N. C., Rijkers, D. T. S., Killian, J. A., de Kroon, A. I. P. M., & de Kruijff, B. (2003). Phospholipid flop induced by transmembrane peptides in model membranes is modulated by lipid composition. Biochemistry, 42, 231-237.
Weiss, T. M., van der Wel, P. C. A., Killian, J. A., Koeppe II, R. E., & Huang, H. W. (2003). Hydrophobic mismatch between helices and lipid bilayers. Biophysical Journal, 84(1), 379-385. https://doi.org/10.1016/S0006-3495(03)74858-9
Chupin, V. V., Killian, J. A., & de Kruijff, B. (2003). Effect of phospholipids and a transmembrane peptide on the stability of the cubic phase of monoolein: implication for protein crystallization from a cubic phase. Biophysical Journal, 84, 2373-2381.
https://dspace.library.uu.nl/bitstream/handle/1874/14367/Chupin-Effect%2520of%2520phospholipids.pdf?sequence=1
Strandberg, E. J., & Killian, J. A. (2003). Snorkeling of lysine side chains in transmembrane helices: how easy can it get? FEBS Letters, 544, 69-73.

2002

Wetenschappelijke publicaties

De Planque, M. R. R., Boots, J. W. P., Rijkers, D. T. S., Liskamp, R. M. J., Greathouse, D. V., & Killian, J. A. (2002). The effects of hydrophobic mismatch between phosphatidylcholine bilayers and transmembrane α-helical peptides depend on the nature of interfacially exposed aromatic and charged residues. Biochemistry, 41(26), 8396-8404. https://doi.org/10.1021/bi0257686
Strandberg, E. J., Morein, S., Rijkers, D. T. S., Liskamp, R. M. J., van der Wel, P. C. A., & Killian, J. A. (2002). Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides. Biochemistry, 41, 7190-7198.
https://dspace.library.uu.nl/bitstream/handle/1874/14363/Strandberg-Lipid%2520dependence.pdf?sequence=1
Ridder, A. N. J. A., Thissen, L., Killian, J. A., & de Kruijff, B. (2002). Insertion and glycosylation of Pf3-derived membrane proteins in microsomes. FEBS Letters, 512, 341-344.
https://dspace.library.uu.nl/bitstream/handle/1874/14247/Ridder-Insertion%2520and%2520glycosylation.pdf?sequence=1
Chupin, V. V., Boots, J. W. P., Killian, J. A., Demel, R. A., & de Kruijff, B. (2002). Thermotropic phase behavior of monoglyceride-dicetylphosphate dispersions and interactions with proteins: a 2H and 31P study. Biophysical Journal, 82, 843-851.
https://dspace.library.uu.nl/bitstream/handle/1874/14254/Chupin-Thermotropic%2520phase.pdf?sequence=1
de Planque, M. R. R., Boots, J. W. P., Rijkers, D. T. S., Liskamp, R. M. J., Greathouse, D. V., & Killian, J. A. (2002). The effects of hydrophobic mismatch between phosphatidylcholine bilayers and transmembrane alpha-helical peptides depend on the nature of interfacially exposed aromatic and charged residues. Biochemistry, 41, 8396-8404.
https://dspace.library.uu.nl/bitstream/handle/1874/14257/DePlanque-The%2520effects%2520of.pdf?sequence=1
van Dalen, A., Hegger, S., Killian, J. A., & de Kruijff, B. (2002). Influence of lipids on membrane assembly and stability of the potassium channel KcsA. FEBS Letters, 525, 33-38.
https://dspace.library.uu.nl/bitstream/handle/1874/14256/VanDalen-Infuence%2520of%2520lipids.pdf?sequence=1
van Dalen, A., van der Laan, M., Driessen, A. J. M., Killian, J. A., & de Kruijff, B. (2002). Components required for membrane assembly of newly synthesized K+ channel KcsA. FEBS Letters, 511, 51-58.
https://dspace.library.uu.nl/bitstream/handle/1874/14255/VanDalen-Components%2520required.pdf?sequence=1
Morein, S., Killian, J. A., & Sperotto, M. M. (2002). Characterization of the thermotropic behavior and lateral organization of lipid-peptide mixtures by a combined experimental and theoretical approach: effects of hydrophobic mismatch and role of flanking residues. Biophysical Journal, 82, 1405-1417.
https://dspace.library.uu.nl/bitstream/handle/1874/14246/Morein-Characterization.pdf?sequence=1
van der Wel, P. C. A., Strandberg, E. J., Killian, J. A., & Koeppe II, R. E. (2002). Geometry and intrinsic tilt of a tryptophan-anchored transmembrane a-helix determined by 2H NMR. Biophysical Journal, 83, 1479-1488. https://www.sciencedirect.com/science/article/pii/S0006349502739180
Demmers, J. A. A., Rijkers, D. T. S., Haverkamp, J., Killian, J. A., & Heck, A. J. R. (2002). Factors affecting gas-phase deuterium scrambling in peptide ions and their implications for protein structure determination. Journal of the American Chemical Society, 124, 11191-11198.
https://dspace.library.uu.nl/bitstream/handle/1874/14253/Demmers-Factors%2520affecting.pdf?sequence=1
Ridder, A. N. J. A., van de Hoef, W., Stam, J., Kuhn, A., de Kruijff, B., & Killian, J. A. (2002). Importance of hydrophobic matching for spontaneous insertion of a single-spanning membrane protein. Biochemistry, 41, 4946-4952.
Petrache, H. I., Zuckerman, D. M., Sachs, J. N., Killian, J. A., Koeppe II, R. E., & Woolf, T. B. (2002). Hydrophobic matching mechanism investigated by molecular dynamics simulations. Langmuir, 18, 1340-1351.
Rinia, H. A., Boots, J. W. P., Rijkers, D. T. S., Kik, R. A., Snel, M. M. E., Demel, R. A., Killian, J. A., van der Eerden, J. P. J. M., & de Kruijff, B. (2002). Domain formation in phosphatidylcholine bilayers containing transmembrane peptides: specific effects of flanking residues. Biochemistry, 41, 2814-2824.
https://dspace.library.uu.nl/bitstream/handle/1874/14362/Rinia-Domain%2520formation.pdf?sequence=1
Boots, J. W. P., Chupin, V. V., Killian, J. A., Demel, R. A., & de Kruijff, B. (2002). The effect of protein stability on protein-monoglyceride interactions. Chemistry and Physics of Lipids, 117, 75-81.
https://dspace.library.uu.nl/bitstream/handle/1874/14358/Boots-The%2520effect%2520of.pdf?sequence=1
van Duyl, B. Y., Rijkers, D. T. S., de Kruijff, B., & Killian, J. A. (2002). Influence of hydrophobic mismatch and palmitoylation on the association of transmembrane α-helical peptides with detergent-resistant membranes. FEBS Letters, 523, 79-84.
https://dspace.library.uu.nl/bitstream/handle/1874/14359/VanDuyl-Influence.pdf?sequence=1

Overige resultaten

Strandberg, E. J., Rijkers, D. T. S., & Killian, J. A. (2002). Structure and dynamics of alpha-helical membrane-spanning model peptides determined in unoriented phospholipid systems using solid state NMR. 144a. Abstract from Unknown event, Asilomar, USA.
Kol, M. A., de Kroon, A. I. P. M., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2002). The transmembrane domains of membrane-spanning proteins induce phospholipid flop. 147a. Abstract from Unknown event, Asilomar, USA.

2001

Wetenschappelijke publicaties

de Planque, M. R. R., Goormaghtigh, E., Greathouse, D. V., Koeppe, R. E., Kruijtzer, J. A. W., Liskamp, R. M. J., de Kruijff, B., & Killian, J. A. (2001). Sensitivity of single membrane-spanning alpha-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane incorporation. Biochemistry, 40, 5000-5010.
Greathouse, D. V., Killian, J. A., Goforth, R. L., Crawford, T., & van der Wel, P. C. A. (2001). Optimized aminolysis conditions for cleavage of N-protected hydrophobic peptides from solidphase resins. Journal of Peptide Research, 57, 519-527.
de Planque, M. R. R., Goormaghtigh, E., Greathouse, D. V., Koeppe II, R. E., Kruijtzer, J. A. W., Liskamp, R. M. J., de Kruijff, B., & Killian, J. A. (2001). Sensitivity of single membrane spanning a-helical peptides to hydrophobic mismatch with a lipid bilayer: effects on backbone structure, orientation, and extent of membrane corporation. Biochemistry, 40, 5000-5010.
van den Brink - van der Laan, E., Dalbey, R. E., Demel, R. A., Killian, J. A., & de Kruijff, B. (2001). Effect of nonbilayer lipids on membrane binding and insertion of the catalytic domain of leader peptidase. Biochemistry, 40, 9677-9684.
Chupin, V. V., Boots, J. W. P., Killian, J. A., Demel, R. A., & de Kruijff, B. (2001). Lipid organization and dynamics of the monostearoylglycerol-water system. Chemistry and Physics of Lipids, 109, 15-28.
Kol, M. A., de Kroon, A. I. P. M., Rijkers, D. T. S., Killian, J. A., & de Kruijff, B. (2001). Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli. Biochemistry, 40, 10500-10506.
Demmers, J. A. A., van Duijn, E., Haverkamp, J., Greathouse, D. V., Koeppe II, R. E., Heck, A. J. R., & Killian, J. A. (2001). Interfacial positioning and stability of transmembrane peptides in lipid bilayers studied by combining hydrogen/deuterium exchange and mass spectrometry. Journal of Biological Chemistry, 276, 34501-34508.
Boots, J. W. P., Chupin, V. V., Killian, J. A., Demel, R. A., & de Kruijff, B. (2001). The specificity of monoglyceride-protein interactions and the mechanism of the protein induced Lbeta to coagel phase transition. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1510, 401-413.
Killian, J. A., & van Meer, G. (2001). The 'double lives' of membrane lipids. EMBO Reports, 2(2), 91-95. https://doi.org/10.1093/embo-reports/kve029
Ridder, A. N. J. A., Kuhn, A., Killian, J. A., & de Kruijff, B. (2001). Anionic lipids stimulate Sec-independent insertion of a membrane protein lacking charged amino acid side chains. EMBO Reports, 2, 403-408.
Heipieper, H. J., de Waard, P., van der Meer, P. J., Killian, J. A., Isken, S., de Bont, J. A. M., Eggink, G., & de Wolf, F. A. (2001). Regiospecific effect of 1-octanol on cistrans isomerization of unsaturated fatty acids in the solvent-tolerant strain Pseudomonas putida S12. Applied Microbiology and Biotechnology, 57, 541-547.

2000

Wetenschappelijke publicaties

Demmers, J. A. A., Haverkamp, J., Heck, A. J. R., Koeppe, R. E., & Killian, J. A. (2000). Electrospray ionazation mass spectrometry as a tool to analyze hydrogen/deuterium exchange kinetics to transmembrane peptides in lipid bilayers. Proceedings of the National Academy of Sciences of the United States of America, 97, 3189-3194.

1999

Wetenschappelijke publicaties

de Planque, M. R. R., Kruijtzer, J. A. W., Liskamp, R. M. J., Marsh, D., Greathouse, D. V., Koeppe II, R. E., de Kruijff, B., & Killian, J. A. (1999). Different membrane anchoring positions of tryptophan and lysine in synthetic transmembrane alpha-helical peptides. Journal of Biological Chemistry, 274, 20839-20846.
Ortiz, A., Killian, J. A., Verkleij, A. J., & Wilschut, J. (1999). Membrane fusion and the lamellar-to-hexagonal phase transition in cardiolipin vesicle systems induced by divalent cations. Biophysical Journal, 77, 2003-2014.

1995

Wetenschappelijke publicaties

Chupin, V., Killian, J. A., Breg, J., de Jongh, H. H., Boelens, R., Kaptein, R., & de Kruijff, B. (1995). PhoE signal peptide inserts into micelles as a dynamic helix-break-helix structure, which is modulated by the environment. A two-dimensional 1H NMR study. Biochemistry, 34(36), 11617-24.
Chupin, V., Killian, J. A., Breg, J., De Jongh, H. H. J., Boelens, R., Kaptein, R., & De Kruijff, B. (1995). PhoE signal peptide inserts into micelles as a dynamic helix-break-helix structure, which is modulated by the environment. A two-dimensional1H NMR study. Biochemistry, 34(36), 11617-11624. https://doi.org/10.1021/bi00036a038

1992

Wetenschappelijke publicaties

Kruijff, B. D., Breukink, E., Demel, R. A., T Hof, R. V., Jongh, H. H. J. D., Jordi, W., Keller, R. C. A., Killian, J. A., Kroon, A. I. P. M. D., Kusters, R., & Pilon, M. (1992). Lipid involvement in protein translocation. New Comprehensive Biochemistry, 22(C), 85-101. https://doi.org/10.1016/S0167-7306(08)60085-X

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